TDMS Study 05090-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
COUMARIN
NTP Experiment-Test: 05090-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/12/94
Route: GAVAGE Time: 06:23:02
Facility: American Biogenics Corp.
Chemical CAS #: 91-64-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 18 20 19 19
Early Deaths
Dead 7 5 3 13
Moribund 8 5 5 8
Gavage Death 4 1 2
Survivors
Terminal Sacrifice 33 39 42 28
Moribund 1
Animals Examined Microscopically 60 58 58 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (46) (48) (50)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (49) (46) (48) (50)
Hyperplasia, Lymphoid 1 (2%)
Liver (58) (50) (53) (59)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 2 (3%) 1 (2%) 4 (7%)
Clear Cell Focus 1 (2%) 2 (3%)
Congestion 3 (5%)
Cytoplasmic Alteration 1 (2%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 4 (7%) 21 (42%) 22 (42%) 9 (15%)
Fatty Change 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Lymphocyte 8 (14%) 2 (4%) 1 (2%) 3 (5%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 2 (4%) 2 (4%) 1 (2%)
Mineralization 3 (5%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis, Coagulative 3 (5%) 2 (4%) 2 (4%) 11 (19%)
Pigmentation 1 (2%)
Syncytial Alteration 2 (4%) 23 (39%)
Vacuolization Cytoplasmic 3 (5%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Hypertrophy 25 (42%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (7) (6) (3) (4)
Cyst 1 (14%)
Fat, Necrosis, Coagulative 5 (71%) 3 (50%) 2 (67%) 4 (100%)
Pancreas (56) (48) (48) (54)
Atrophy 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Infiltration Cellular, Lymphocyte 10 (18%) 4 (8%) 9 (19%) 10 (19%)
Inflammation, Suppurative 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Pharynx (1)
Cyst 1 (100%)
Salivary Glands (59) (50) (51) (60)
Infiltration Cellular, Lymphocyte 22 (37%) 14 (28%) 16 (31%) 25 (42%)
Stomach, Forestomach (56) (50) (50) (55)
Hyperkeratosis 4 (8%) 1 (2%)
Hyperplasia, Squamous 2 (4%) 5 (10%)
Inflammation, Suppurative 2 (4%)
Stomach, Glandular (54) (48) (50) (50)
Dilatation 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (50) (51) (60)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%) 2 (3%)
Necrosis, Zenkers 1 (2%)
Nuclear Alteration 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Mineralization 1 (2%)
Perivascular, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (57) (47) (48) (60)
Corticomedullary Junction, Hemorrhage 1 (2%) 1 (2%)
Corticomedullary Junction, Necrosis,
Coagulative 1 (2%)
Spindle Cell, Hyperplasia 42 (74%) 13 (28%) 23 (48%) 24 (40%)
Adrenal Gland, Cortex (57) (47) (47) (60)
Clear Cell Focus 1 (2%)
Cytoplasmic Alteration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 2 (4%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Corticomedullary Junction, Necrosis,
Coagulative 1 (2%)
Adrenal Gland, Medulla (57) (47) (48) (59)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (57) (48) (48) (56)
Atrophy 1 (2%)
Parathyroid Gland (40) (38) (40) (48)
Ectopic Thymus 1 (2%)
Hyperplasia 1 (3%)
Pituitary Gland (53) (45) (45) (57)
Pars Distalis, Cyst 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Thyroid Gland (55) (49) (50) (56)
Inflammation, Suppurative 1 (2%) 1 (2%)
C-Cell, Hyperplasia 2 (4%) 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicle, Dilatation 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 4 (8%) 6 (12%) 4 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1)
Hemorrhage 1 (50%)
Abdominal, Necrosis, Coagulative 1 (50%)
Posterior, Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (59) (52) (52) (60)
Hematocyst 2 (3%) 1 (2%) 1 (2%) 2 (3%)
Inflammation, Suppurative 2 (3%) 2 (4%)
Pigmentation, Ceroid 1 (2%)
Bilateral, Corpus Luteum, Cyst 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Follicle, Cyst 13 (22%) 16 (31%) 15 (29%) 6 (10%)
Follicle, Hematocyst 1 (2%)
Uterus (58) (55) (51) (60)
Hydrometra 10 (17%) 10 (18%) 6 (12%) 12 (20%)
Hyperplasia, Cystic 31 (53%) 26 (47%) 35 (69%) 29 (48%)
Inflammation, Suppurative 3 (5%) 4 (7%) 2 (4%) 3 (5%)
Endometrium, Hyperplasia, Cystic 1 (2%)
Vagina (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hyperkeratosis 1 (100%)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (48) (49) (60)
Hyperplasia, Neutrophil 1 (2%)
Myelofibrosis 2 (4%)
Lymph Node (57) (49) (49) (59)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Inflammation, Chronic Active 1 (2%)
Lymph Node, Mandibular (55) (47) (49) (53)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (53) (45) (48) (56)
Amyloid Deposition 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 4 (9%) 7 (15%) 2 (4%)
Hyperplasia, Macrophage 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Necrosis 1 (2%)
Spleen (58) (48) (48) (57)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Congestion 1 (2%)
Developmental Malformation 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation Erythrocytic 2 (4%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 4 (7%) 5 (10%) 6 (13%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Suppurative 2 (3%) 1 (2%)
Thymus (51) (44) (49) (51)
Atrophy 1 (2%) 1 (2%) 3 (6%)
Hyperplasia, Lymphoid 2 (5%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis, Coagulative 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (48) (50) (59)
Inflammation, Necrotizing 1 (2%)
Duct, Dilatation 1 (2%)
Duct, Hyperplasia 1 (2%)
Skin (59) (51) (56) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Alopecia 5 (8%) 5 (10%) 7 (13%) 5 (8%)
Hyperkeratosis 1 (2%)
Foot, Inflammation, Suppurative 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57) (49) (50) (58)
Hypothalamus, Compression 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 2 (3%)
Thalamus, Compression 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (50) (50) (60)
Congestion 2 (3%) 1 (2%)
Foreign Body 3 (5%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 2 (4%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 4 (8%) 4 (7%)
Alveolus, Hemorrhage 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Alveolus, Infiltration Cellular, Lymphocyte 1 (2%)
Alveolus, Inflammation, Chronic 1 (2%)
Bronchiole, Inflammation, Suppurative 1 (2%)
Bronchiole, Epithelium, Hyperplasia 1 (2%) 4 (7%)
Bronchiole, Epithelium, Necrosis 3 (5%)
Mediastinum, Foreign Body 1 (2%)
Peribronchial, Inflammation, Suppurative 1 (2%)
Peribronchiolar, Hemorrhage 1 (2%)
Pleura, Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Subpleura, Mineralization 1 (2%)
Nose (58) (50) (51) (59)
Lumen, Inflammation, Suppurative 2 (4%) 5 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (47) (49) (58)
Glomerulosclerosis 2 (3%) 1 (2%)
Infiltration Cellular, Lymphocyte 8 (14%) 5 (11%) 8 (16%) 6 (10%)
Nephropathy 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Collecting Tubule, Mineralization 1 (2%)
Collecting Tubule, Necrosis, Coagulative 1 (2%)
Collecting Tubule, Pigmentation, Hemoglobin 1 (2%)
Cortex, Cyst Multilocular 1 (2%)
Cortex, Pigmentation, Bile 1 (2%)
Pelvis, Infiltration Cellular, Lymphocyte 4 (7%) 9 (16%)
Renal Tubule, Degeneration 1 (2%) 1 (2%)
Urinary Bladder (53) (47) (48) (56)
Infiltration Cellular, Lymphocyte 27 (51%) 14 (30%) 23 (48%) 20 (36%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 19
Early Deaths
Dead 5 3 1 11
Moribund 1 6 3
Gavage Death 1 1
Survivors
Terminal Sacrifice 43 47 42 37
Animals Examined Microscopically 60 58 57 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (59) (49) (49) (60)
Periesophageal Tissue, Edema 1 (2%)
Intestine Large, Cecum (57) (47) (49) (51)
Hyperplasia, Lymphoid 3 (5%) 5 (10%)
Inflammation, Chronic 1 (2%)
Necrosis, Coagulative 1 (2%)
Intestine Large, Colon (56) (50) (49) (52)
Inflammation, Chronic 1 (2%)
Intestine Small, Ileum (58) (47) (49) (51)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymphoid Tissue, Inflammation, Suppurative 1 (2%) 1 (2%)
Intestine Small, Jejunum (56) (47) (50) (51)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%)
Liver (60) (54) (56) (60)
Angiectasis 2 (3%)
Basophilic Focus 1 (2%) 4 (7%) 2 (4%) 3 (5%)
Clear Cell Focus 4 (7%) 7 (13%) 8 (14%) 11 (18%)
Congestion 1 (2%) 1 (2%) 7 (12%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 6 (10%) 15 (28%) 13 (23%) 15 (25%)
Fatty Change 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mixed Cell Focus 4 (7%) 3 (6%) 4 (7%) 1 (2%)
Necrosis, Coagulative 3 (5%) 1 (2%) 8 (13%)
Syncytial Alteration 7 (13%) 39 (70%) 56 (93%)
Vacuolization Cytoplasmic 13 (22%) 1 (2%) 11 (20%) 6 (10%)
Centrilobular, Hypertrophy 1 (2%) 2 (4%) 23 (41%) 52 (87%)
Mesentery (8) (3) (3) (3)
Inflammation, Granulomatous 1 (13%)
Fat, Hemorrhage 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Inflammation, Chronic 2 (25%) 1 (33%)
Fat, Inflammation, Suppurative 1 (13%)
Fat, Necrosis, Coagulative 4 (50%) 2 (67%) 1 (33%) 2 (67%)
Fat, Necrosis, Liquifactive 2 (25%)
Pancreas (59) (50) (50) (59)
Atrophy 3 (6%) 1 (2%) 1 (2%)
Degeneration 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 3 (6%) 4 (7%)
Inflammation, Granulomatous 1 (2%)
Necrosis, Coagulative 1 (2%)
Polyarteritis 1 (2%)
Salivary Glands (59) (50) (50) (60)
Infiltration Cellular, Lymphocyte 16 (27%) 19 (38%) 14 (28%) 21 (35%)
Stomach, Forestomach (58) (49) (50) (56)
Hemorrhage 1 (2%)
Hyperkeratosis 2 (3%) 2 (4%)
Hyperplasia, Squamous 1 (2%) 3 (6%) 3 (6%)
Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (56) (48) (50) (53)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (50) (60)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 4 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (59) (49) (49) (59)
Spindle Cell, Hyperplasia 12 (20%) 12 (24%) 6 (12%) 10 (17%)
Adrenal Gland, Cortex (59) (49) (49) (59)
Basophilic Focus 1 (2%)
Clear Cell Focus 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Cytomegaly 1 (2%)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Hypertrophy 1 (2%) 1 (2%)
Islets, Pancreatic (59) (50) (50) (59)
Hyperplasia 1 (2%) 3 (6%) 1 (2%)
Pituitary Gland (52) (46) (40) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Fibrosis 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Thyroid Gland (58) (50) (50) (60)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Follicular Cell, Cyst 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 2 (3%) 6 (12%) 3 (6%) 2 (3%)
Follicular Cell, Hyperplasia, Papillary 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Mediastinum, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (59) (50) (50) (59)
Granuloma 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Preputial Gland (16) (21) (13) (9)
Hyperplasia 1 (6%)
Inflammation, Suppurative 1 (6%) 1 (5%) 1 (8%)
Duct, Dilatation 14 (88%) 19 (90%) 12 (92%) 7 (78%)
Prostate (59) (50) (50) (60)
Infiltration Cellular, Lymphocyte 2 (3%) 1 (2%) 3 (5%)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (59) (50) (50) (60)
Dilatation 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%)
Testes (59) (50) (50) (59)
Atrophy 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (50) (50) (59)
Hyperplasia, Neutrophil 1 (2%)
Lymph Node (59) (50) (49) (60)
Deep Cervical, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (57) (48) (48) (54)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mesenteric (59) (49) (47) (56)
Congestion 2 (3%) 1 (2%) 1 (2%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 5 (8%) 2 (4%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 2 (3%)
Spleen (59) (50) (51) (59)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%)
Congestion 1 (2%) 1 (2%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation Erythrocytic 4 (7%) 1 (2%)
Hyperplasia, Lymphoid 4 (7%) 1 (2%) 3 (6%) 2 (3%)
Lymphocyte, Atrophy 1 (2%)
Thymus (57) (45) (44) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (59) (51) (51) (60)
Alopecia 3 (5%) 5 (10%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (50) (50) (60)
Metacarpal, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (50) (50) (59)
Meninges, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (52) (51) (60)
Congestion 2 (3%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (5%) 1 (2%) 4 (8%) 5 (8%)
Alveolus, Hemorrhage 2 (4%)
Bronchiole, Dilatation, Focal 1 (2%)
Bronchiole, Epithelium, Hyperplasia 2 (4%) 1 (2%)
Bronchiole, Epithelium, Necrosis 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05090-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 06:23:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG 200MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Pleura, Inflammation, Suppurative 1 (2%)
Nose (59) (50) (50) (60)
Fungus 1 (2%)
Inflammation, Suppurative 1 (2%)
Lumen, Inflammation, Suppurative 4 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (1)
Inflammation, Chronic, Diffuse 1 (100%)
Retrobulbar, Infiltration Cellular, Focal,
Lymphocyte 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (50) (50) (58)
Ectopic Tissue 1 (2%)
Fibrosis 1 (2%)
Glomerulosclerosis 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 5 (8%) 4 (8%) 4 (8%) 5 (9%)
Nephropathy 8 (14%) 12 (24%) 8 (16%) 3 (5%)
Collecting Tubule, Necrosis, Coagulative 1 (2%) 1 (2%)
Cortex, Cyst 1 (2%) 4 (8%)
Cortex, Cyst Multilocular 1 (2%) 1 (2%) 1 (2%)
Glomerulus, Inflammation, Chronic 1 (2%)
Pelvis, Infiltration Cellular, Lymphocyte 5 (8%) 2 (3%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Necrosis, Coagulative 1 (2%) 2 (4%) 3 (6%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
Urethra (1)
Inflammation, Chronic Active 1 (100%)
Urinary Bladder (59) (50) (50) (57)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 4 (7%) 2 (4%) 4 (8%) 9 (16%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------