TDMS Study 05090-02 Pathology Tables
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
Facility: American Biogenics Corp.
Chemical CAS #: 91-64-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|
| 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + A + + + + M A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + M + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | |
Basophilic Focus | |
Cytoplasmic Alteration | |
Developmental Malformation | |
Eosinophilic Focus | 2 |
Hemorrhage | |
Infiltration Cellular, Plasma Cell | 2 |
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Chronic | |
Necrosis, Coagulative | 4 1 |
Pigmentation | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Cyst | |
Fat, Necrosis, Coagulative | 2 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + +|
Atrophy | 2 |
Fibrosis | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + A + + + + + A + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|
| 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + A + +|
Spindle Cell, Hyperplasia | 2 2 3 2 1 2 2 2 3 2 2 2 2 1 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + A + +|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M I M + + M M M M + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + M + + + + M A + +|
Pars Distalis, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + I + + + + + + + + A + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Hematocyst | 4 |
Inflammation, Suppurative | 4 |
Follicle, Cyst | 4 4 3 4 4 2 4 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 4 3 3 |
Hyperplasia, Cystic | 2 3 3 2 3 2 2 2 2 2 3 2 4|
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Vagina | + |
Hyperkeratosis | 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + A + + + + + M + +|
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Macrophage | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | |
Congestion | |
Hyperplasia, Lymphoid | 3|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|
| 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Hyperkeratosis | 2 |
Foot, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + A + + + + + A + +|
Hypothalamus, Compression | X |
Thalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | |
Hyperplasia, Histiocytic | 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
Alveolus, Hemorrhage | |
Mediastinum, Foreign Body | |
Peribronchiolar, Hemorrhage | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + +|
Glomerulosclerosis | 2 |
Infiltration Cellular, Lymphocyte | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|
| 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Necrosis, Fibrinoid | |
Collecting Tubule, Pigmentation, | |
Hemoglobin | 3 |
Pelvis, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + A M +|
Infiltration Cellular, Lymphocyte | 1 1 2 3 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|
DAY ON TEST | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|
| 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + M + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + I + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 |
Cytoplasmic Alteration | |
Developmental Malformation | |
Eosinophilic Focus | 3 |
Hemorrhage | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Inflammation, Chronic | |
Necrosis, Coagulative | 2 |
Pigmentation | 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Cyst | |
Fat, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | |
Infiltration Cellular, Lymphocyte | 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|
DAY ON TEST | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|
| 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 2 2 2 2 3 1 2 2 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M + + M M + + M + M + M + M + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Hematocyst | 4 |
Inflammation, Suppurative | 4 |
Follicle, Cyst | 4 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 |
Hyperplasia, Cystic | 3 2 2 2 4 3 2 2 2 2|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Vagina | |
Hyperkeratosis | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Congestion | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|
DAY ON TEST | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|
| 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + + + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Alopecia | 3 2 |
Hyperkeratosis | |
Foot, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
Thalamus, Compression | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Suppurative | 3 |
Alveolus, Hemorrhage | |
Mediastinum, Foreign Body | |
Peribronchiolar, Hemorrhage | 3 |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 4 |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|
DAY ON TEST | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|
| 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Necrosis, Fibrinoid | |
Collecting Tubule, Pigmentation, | |
Hemoglobin | |
Pelvis, Infiltration Cellular, | |
Lymphocyte | 2 1 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + A + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 1 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7| | |
DAY ON TEST | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3| | |
| 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + A + + + + + + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + A + A A + + + M + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + A + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + + A + A + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + A + + + + + + A + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A M A + + + M + + A + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + A + + + + + + A A + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + A + + + + + + A A + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + + A + M M + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + A + A A + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + A + + + + + + + + + + + + + + + | 58 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | 1 | 2 1.5|
Cytoplasmic Alteration | 1 | 1 1.0|
Developmental Malformation | X | 1 |
Eosinophilic Focus | 2 3 | 4 2.5|
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 2 | 8 1.8|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis, Coagulative | | 3 2.3|
Pigmentation | | 1 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Cyst | 4 | 1 4.0|
Fat, Necrosis, Coagulative | | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + A A + + + + + | 56 |
Atrophy | | 2 2.5|
Fibrosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 2 2 | 10 1.9|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + A + + + + + + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | 2 1 2 1 2 2 1 2 2 2 1 1 | 22 1.7|
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + A + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + A + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + A + + + + + + | 54 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7| | |
DAY ON TEST | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3| | |
| 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + A + + + + + + + + + + + + + + + | 59 |
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + + + + + + + + M + | 57 |
Spindle Cell, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 3 2 3 | 42 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + M + | 57 |
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + M + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + A + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + M + + + M + + | 40 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M M + + + + + + + + + + + + + + I | 53 |
Pars Distalis, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + A + + + + + + | 55 |
Follicular Cell, Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + A + + + + + + + + + + + + + + + | 59 |
Hematocyst | | 2 4.0|
Inflammation, Suppurative | | 2 4.0|
Follicle, Cyst | 4 3 4 | 13 3.6|
__________________________________________________________________________|____________|
Uterus | + + + A + A + + + + + + + + + + + + + | 58 |
Hydrometra | 4 2 4 3 | 10 3.2|
Hyperplasia, Cystic | 2 4 2 3 2 2 2 3 | 31 2.5|
Inflammation, Suppurative | | 3 2.7|
__________________________________________________________________________|____________|
Vagina | | 1 |
Hyperkeratosis | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + + + A A + + + + + | 57 |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + A M + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7| | |
DAY ON TEST | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3| | |
| 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + A A + + + + + | 53 |
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia, Macrophage | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + + + + + + | 58 |
Angiectasis | | 1 3.0|
Atrophy | | 1 3.0|
Congestion | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 2 2 | 4 2.3|
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + M A + + + + + + + + A A I + + M + | 51 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + A + + + + + + M + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Skin | + + + A + + + + + + + + + + + + + + + | 59 |
Alopecia | 1 2 3 | 5 2.2|
Hyperkeratosis | | 1 2.0|
Foot, Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + A + + + + + + + + + + + + + + + | 57 |
Hypothalamus, Compression | | 1 |
Thalamus, Compression | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + A + + + + + + + + + + + + + + + | 59 |
Congestion | | 2 3.0|
Foreign Body | 2 2 | 3 2.0|
Hyperplasia, Histiocytic | | 1 1.0|
Hyperplasia, Lymphoid | 2 1 | 3 1.7|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Alveolus, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7| | |
DAY ON TEST | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3| | |
| 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Foreign Body | 4 | 1 4.0|
Peribronchiolar, Hemorrhage | | 1 3.0|
Pleura, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + A + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Trachea | + + + A + + + + + + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + | 58 |
Glomerulosclerosis | | 2 3.0|
Infiltration Cellular, Lymphocyte | 2 3 1 1 | 8 1.8|
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
Collecting Tubule, Pigmentation, | | |
Hemoglobin | | 1 3.0|
Pelvis, Infiltration Cellular, | | |
Lymphocyte | 2 | 4 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + A + + + + + | 53 |
Infiltration Cellular, Lymphocyte | 3 2 3 2 4 2 1 2 2 2 | 27 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|
DAY ON TEST | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|
| 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + M I + + + A + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + I + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Eosinophilic Focus | 1 4 2 1 2 3 2 |
Fatty Change | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Necrotizing | |
Inflammation, Suppurative | 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 4 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Coagulative | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
Infiltration Cellular, Lymphocyte | 2 2 |
__________________________________________________________________________|
Pharynx | |
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 3 3 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
Perivascular, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + A + + + + + + |
Corticomedullary Junction, Hemorrhage| 3 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|
DAY ON TEST | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|
| 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Corticomedullary Junction, Necrosis, | |
Coagulative | |
Spindle Cell, Hyperplasia | 1 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + A + + + + + + |
Necrosis, Coagulative | |
Corticomedullary Junction, Necrosis, | |
Coagulative | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + A + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M + + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + M + + + + + M |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicle, Dilatation | 3 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | |
Abdominal, Necrosis, Coagulative | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Hematocyst | 3 |
Inflammation, Suppurative | 3 |
Capsule, Inflammation, Chronic | |
Follicle, Cyst | 3 2 3 3 2 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Hydrometra | 4 3 |
Hyperplasia, Cystic | 2 3 4 2 3 3 2 3 3 3 2 3 |
Inflammation, Suppurative | 2 4 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + I + + + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|
DAY ON TEST | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|
| 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 3 |
Hyperplasia, Lymphoid | 2 3 3 3 |
Hyperplasia, Plasma Cell | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + A + + + + + + |
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + |
Duct, Dilatation | 3 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Alopecia | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Hemorrhage | 2 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + A + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|
DAY ON TEST | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|
| 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulosclerosis | 3 |
Infiltration Cellular, Lymphocyte | 2 2 |
Cortex, Pigmentation, Bile | 2 |
Renal Tubule, Degeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + M + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 2 2 2 1 2 3 3 1 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|
| 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
50 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A A + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Eosinophilic Focus | 1 2 2 2 3 3 2 2|
Fatty Change | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Necrotizing | |
Inflammation, Suppurative | 1|
Mixed Cell Focus | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + A + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 1 |
__________________________________________________________________________|
Pharynx | + |
Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + +|
Hyperkeratosis | 2 4 |
Hyperplasia, Squamous | 3 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + A + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Perivascular, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + A + + + + + + + A + + + + + + + +|
Corticomedullary Junction, Hemorrhage| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|
| 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
50 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Corticomedullary Junction, Necrosis, | |
Coagulative | |
Spindle Cell, Hyperplasia | 2 2 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + A + + + + + + + A + + + + + + + +|
Necrosis, Coagulative | |
Corticomedullary Junction, Necrosis, | |
Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + A + + + + + + + A + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + A + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Parathyroid Gland | M + M M + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + A + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
Abdominal, Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + + + + + + +|
Hematocyst | |
Inflammation, Suppurative | |
Capsule, Inflammation, Chronic | |
Follicle, Cyst | 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + A + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 3 4 3 |
Hyperplasia, Cystic | 2 3 3 3 3 4 3 2 2 3 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M M + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|
| 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
50 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + A A + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Thymus | + + A M M + + + + + + + + + + + + + I|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + M|
Duct, Dilatation | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + A + + + + + + + + + + + + + + + +|
Alopecia | 3 2 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + A + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Hemorrhage | |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|
| 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
50 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | 2 |
Cortex, Pigmentation, Bile | |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7| | |
DAY ON TEST | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3| | |
| 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 50 |
Basophilic Focus | | 1 3.0|
Eosinophilic Focus | 2 3 2 2 3 3 | 21 2.2|
Fatty Change | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 2 2.0|
Inflammation, Necrotizing | 2 | 1 2.0|
Inflammation, Suppurative | | 2 1.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Coagulative | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis, Coagulative | 3 | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 48 |
Atrophy | 4 | 2 3.5|
Infiltration Cellular, Lymphocyte | | 4 1.8|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 14 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 50 |
Hyperkeratosis | 2 | 4 2.5|
Hyperplasia, Squamous | 3 | 2 3.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 48 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 50 |
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7| | |
DAY ON TEST | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3| | |
| 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Perivascular, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + | 47 |
Corticomedullary Junction, Hemorrhage| | 1 3.0|
Corticomedullary Junction, Necrosis, | | |
Coagulative | 2 | 1 2.0|
Spindle Cell, Hyperplasia | 2 2 | 13 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 47 |
Necrosis, Coagulative | 2 | 1 2.0|
Corticomedullary Junction, Necrosis, | | |
Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + | 47 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 48 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + M + + + + + + M | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 45 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 | 2 2.0|
Follicle, Cyst | 2 | 1 2.0|
Follicle, Dilatation | | 1 3.0|
Follicular Cell, Hyperplasia | 3 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Hemorrhage | 3 | 1 3.0|
Abdominal, Necrosis, Coagulative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 52 |
Hematocyst | | 1 3.0|
Inflammation, Suppurative | 4 | 2 3.5|
Capsule, Inflammation, Chronic | 3 | 1 3.0|
Follicle, Cyst | 3 4 3 4 | 16 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 55 |
Hydrometra | 3 4 3 4 | 10 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7| | |
DAY ON TEST | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3| | |
| 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 2 3 2 | 26 2.7|
Inflammation, Suppurative | | 4 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + | 47 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 45 |
Hyperplasia, Lymphoid | 2 2 | 4 2.5|
Hyperplasia, Plasma Cell | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 48 |
Developmental Malformation | X | 2 |
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 2 2.5|
Hyperplasia, Lymphoid | | 5 2.8|
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + | 44 |
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + | 48 |
Duct, Dilatation | | 1 3.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + | 51 |
Alopecia | 1 | 5 1.8|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7| | |
DAY ON TEST | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3| | |
| 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 4 2.0|
Alveolus, Hemorrhage | | 1 2.0|
Bronchiole, Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 47 |
Glomerulosclerosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 | 5 2.0|
Cortex, Pigmentation, Bile | | 1 2.0|
Renal Tubule, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 2 2 | 14 1.7|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|
| 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 2|
Eosinophilic Focus | 2 2 2 1 2 1 2 2|
Infarct | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Syncytial Alteration | 1 1|
Bile Duct, Cyst | |
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Atrophy | 2|
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 2 3 2 3 2 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Nuclear Alteration | 2 |
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|
| 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + +|
Corticomedullary Junction, Hemorrhage| |
Spindle Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + I + + + + +|
Clear Cell Focus | |
Cytoplasmic Alteration | 3 |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + M M +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Posterior, Abscess | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Hematocyst | 4 |
Pigmentation, Ceroid | |
Follicle, Cyst | 3 3 3 4 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 4 3 |
Hyperplasia, Cystic | 2 3 3 3 3 3 3 2 3 3|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|
| 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 3 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + I + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 2 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Lymphocyte | |
Alveolus, Inflammation, Chronic | |
Pleura, Inflammation, Suppurative | |
Subpleura, Mineralization | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|
| 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 2 1 1 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|
DAY ON TEST | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|
| 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + M + + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + A + A + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Clear Cell Focus | |
Eosinophilic Focus | 3 2 3 1 3 2 4 3 3 |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Mixed Cell Focus | |
Necrosis, Coagulative | 3 |
Syncytial Alteration | |
Bile Duct, Cyst | |
Hepatocyte, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + A + A + + + + + |
Atrophy | |
Hyperplasia | 3 |
Infiltration Cellular, Lymphocyte | 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + A + + + + + |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + A + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Nuclear Alteration | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|
DAY ON TEST | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|
| 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + + + A + A + + + + + |
Corticomedullary Junction, Hemorrhage| 2 |
Spindle Cell, Hyperplasia | 2 1 1 2 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + + + + + + A + A + + + + + |
Clear Cell Focus | |
Cytoplasmic Alteration | |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + A + A + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + A + A + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + I + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + M + + A + + + + + + + |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + |
Inflammation, Suppurative | |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Posterior, Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + A + + + + + |
Hematocyst | |
Pigmentation, Ceroid | 2 |
Follicle, Cyst | 2 3 |
__________________________________________________________________________|
Uterus | + + + + M + + + + + + + + + A + + + + + |
Hydrometra | 4 |
Hyperplasia, Cystic | 2 3 4 4 2 2 3 2 3 3 3 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + A + A + + + + + |
Hyperplasia, Neutrophil | 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + A + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + A + + + + + |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|
DAY ON TEST | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|
| 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 3 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + M + + + + + + + + + A + A + + + + + |
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + A + + + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Alopecia | 3 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + A + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + A + A + + + + + |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 4 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Hemorrhage | 1 |
Alveolus, Infiltration Cellular, | |
Lymphocyte | |
Alveolus, Inflammation, Chronic | |
Pleura, Inflammation, Suppurative | 3 |
Subpleura, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|
DAY ON TEST | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|
| 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + A + + + + + |
Infiltration Cellular, Lymphocyte | 3 2 |
Renal Tubule, Degeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + A + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 3 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3| | |
| 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 53 |
Angiectasis | 3 | 1 3.0|
Clear Cell Focus | | 1 2.0|
Eosinophilic Focus | 3 2 2 2 3 | 22 2.3|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Suppurative | 2 | 2 2.0|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis, Coagulative | 1 | 2 2.0|
Syncytial Alteration | | 2 1.0|
Bile Duct, Cyst | 4 | 1 4.0|
Hepatocyte, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis, Coagulative | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 2.0|
Hyperplasia | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 | 9 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 51 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 | 16 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 50 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | | 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3| | |
| 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 3.0|
Nuclear Alteration | | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 48 |
Corticomedullary Junction, Hemorrhage| | 1 2.0|
Spindle Cell, Hyperplasia | 2 2 2 2 2 | 23 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 47 |
Clear Cell Focus | 3 | 1 3.0|
Cytoplasmic Alteration | | 1 3.0|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M M + + M + + + + + + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 45 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 50 |
Inflammation, Suppurative | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | | 1 2.0|
Follicle, Dilatation | | 1 2.0|
Follicular Cell, Hyperplasia | 1 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Posterior, Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + | 52 |
Hematocyst | | 1 4.0|
Pigmentation, Ceroid | | 1 2.0|
Follicle, Cyst | 2 3 3 4 4 3 3 | 15 3.1|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + | 51 |
Hydrometra | 3 | 6 3.3|
Hyperplasia, Cystic | 2 3 3 3 3 4 3 3 2 3 2 3 2 | 35 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3| | |
| 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Neutrophil | | 1 3.0|
Myelofibrosis | 3 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + | 49 |
Hyperplasia, Lymphoid | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + | 48 |
Hyperplasia, Lymphoid | 2 2 3 | 7 2.6|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 48 |
Developmental Malformation | X | 1 |
Hematopoietic Cell Proliferation | | |
Erythrocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 49 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 56 |
Alopecia | 2 | 7 2.1|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3| | |
| 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 3 | 4 1.8|
Alveolus, Hemorrhage | 1 | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
Alveolus, Inflammation, Chronic | 2 | 1 2.0|
Pleura, Inflammation, Suppurative | | 1 3.0|
Subpleura, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 51 |
Lumen, Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 3 | 8 2.1|
Renal Tubule, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 | 23 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|
DAY ON TEST | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|
| 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + A + + + + + A + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + A + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + A + + + + + + + + A|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + A + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + A + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + A + A + + + + + A + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + M + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + A|
__________________________________________________________________________|
Liver | + + + + + + + + A + + + + + + + + +|
Basophilic Focus | 4 |
Clear Cell Focus | 1 1 |
Congestion | 4|
Eosinophilic Focus | 2 2|
Fatty Change | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | |
Mineralization | 2 2 |
Necrosis, Coagulative | 3 3 |
Syncytial Alteration | 1 1 2 1 2 2 1|
Vacuolization Cytoplasmic | 1 2 1 |
Centrilobular, Hypertrophy | 1 1 1 2 2 1 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Coagulative | 4 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + A + + +|
Atrophy | 4 |
Infiltration Cellular, Lymphocyte | 2 1 3 1 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 1 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + A + + A|
Dilatation | |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis, Zenkers | 3 |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|
DAY ON TEST | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|
| 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M M M + + + M M + +|
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + +|
Pars Distalis, Cyst | 3|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + + M + A|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Hematocyst | 3 |
Bilateral, Corpus Luteum, Cyst | |
Follicle, Cyst | 3 |
Follicle, Hematocyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 3 3 4 |
Hyperplasia, Cystic | 3 2 2 2 2 |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + A + + + + + + + + +|
Pancreatic, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + M + + + + + + M + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + A + + + + + + + + +|
Amyloid Deposition | 2 |
Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|
DAY ON TEST | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|
| 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + A + + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + +|
Atrophy | 3 3 |
Hyperplasia, Lymphoid | |
Necrosis, Coagulative | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + A + + + + + + + + A|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Hyperplasia | 2|
Alveolus, Hemorrhage | 3 |
Bronchiole, Inflammation, Suppurative| |
Bronchiole, Epithelium, Hyperplasia | 2 |
Bronchiole, Epithelium, Necrosis | 1 |
Peribronchial, Inflammation, | |
Suppurative | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + +|
Lumen, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + A + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|
DAY ON TEST | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|
| 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | |
Collecting Tubule, Mineralization | 3 |
Collecting Tubule, Necrosis, | |
Coagulative | 2 |
Cortex, Cyst Multilocular | |
Pelvis, Infiltration Cellular, | |
Lymphocyte | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + A + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 1 3 2 1 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + A A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A A A + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A A + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A A A A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A A A A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A M + A A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | |
Congestion | 3 3 |
Eosinophilic Focus | 1 2 2 1|
Fatty Change | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 |
Mineralization | |
Necrosis, Coagulative | 4 4 3 2 3 |
Syncytial Alteration | 1 2 1 1 2 2 1 1 1 1 2 |
Vacuolization Cytoplasmic | |
Centrilobular, Hypertrophy | 1 1 1 2 2 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 3 2 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + A A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + A A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A A A A A + + + + + + + + +|
Dilatation | 3 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis, Zenkers | |
Artery, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 1 2 1 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + M + + + +|
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Hematocyst | X |
Bilateral, Corpus Luteum, Cyst | |
Follicle, Cyst | 3 4 |
Follicle, Hematocyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 3 4 4|
Hyperplasia, Cystic | 3 3 2 3 3 2 4 3 4 2 3 2 2 2|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + +|
Amyloid Deposition | |
Hyperplasia, Histiocytic | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + M M + + + + + + + + + M + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 2 |
Necrosis, Coagulative | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Hemorrhage | |
Bronchiole, Inflammation, Suppurative| 2 |
Bronchiole, Epithelium, Hyperplasia | 2 3 2 |
Bronchiole, Epithelium, Necrosis | |
Peribronchial, Inflammation, | |
Suppurative | |
Pleura, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Suppurative | 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 |
Collecting Tubule, Mineralization | |
Collecting Tubule, Necrosis, | |
Coagulative | |
Cortex, Cyst Multilocular | |
Pelvis, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + A + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 3 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2| | |
| 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A M A + A + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + A + A + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + A + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + A + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + A + A + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + A + A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + A + A + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + A + A + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 59 |
Basophilic Focus | 2 | 4 2.5|
Clear Cell Focus | | 2 1.0|
Congestion | | 3 3.3|
Eosinophilic Focus | 2 2 3 | 9 1.9|
Fatty Change | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 3 1.7|
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | | 1 1.0|
Mineralization | 2 | 3 2.0|
Necrosis, Coagulative | 4 4 3 3 | 11 3.3|
Syncytial Alteration | 1 1 2 1 1 | 23 1.3|
Vacuolization Cytoplasmic | | 3 1.3|
Centrilobular, Hypertrophy | 1 1 2 1 1 2 1 2 1 | 25 1.3|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis, Coagulative | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + A + + + + + + + + + + | 54 |
Atrophy | 1 | 2 2.5|
Infiltration Cellular, Lymphocyte | 2 2 2 2 | 10 1.9|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 2 1 1 2 2 | 25 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + A + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + A + + + + + + + + | 50 |
Dilatation | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2| | |
| 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 60 |
Mineralization | 2 3 | 2 2.5|
Necrosis, Zenkers | | 1 3.0|
Artery, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + | 60 |
Spindle Cell, Hyperplasia | 3 2 1 1 2 3 2 1 | 24 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 3 | 1 3.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + + + + + + M + M + | 48 |
Ectopic Thymus | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + | 57 |
Pars Distalis, Cyst | | 1 3.0|
Pars Distalis, Hyperplasia | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + | 56 |
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + | 60 |
Hematocyst | | 2 3.0|
Bilateral, Corpus Luteum, Cyst | 3 | 1 3.0|
Follicle, Cyst | 3 3 3 | 6 3.2|
Follicle, Hematocyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 60 |
Hydrometra | 3 3 | 12 3.2|
Hyperplasia, Cystic | 3 3 3 2 2 3 3 3 2 2 | 29 2.6|
Inflammation, Suppurative | 4 3 | 3 3.0|
Endometrium, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2| | |
| 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + | 59 |
Pancreatic, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + M + | 53 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + | 56 |
Amyloid Deposition | | 1 2.0|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 57 |
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + I + + + I + I + M | 51 |
Atrophy | 2 | 3 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis, Coagulative | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + | 59 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 60 |
Alopecia | 2 2 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 58 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 2.0|
Alveolus, Hemorrhage | | 1 3.0|
Bronchiole, Inflammation, Suppurative| | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2| | |
| 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchiole, Epithelium, Hyperplasia | | 4 2.3|
Bronchiole, Epithelium, Necrosis | 2 3 | 3 2.0|
Peribronchial, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Pleura, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 59 |
Lumen, Inflammation, Suppurative | | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | | 6 1.5|
Nephropathy | | 1 2.0|
Collecting Tubule, Mineralization | | 1 3.0|
Collecting Tubule, Necrosis, | | |
Coagulative | | 1 2.0|
Cortex, Cyst Multilocular | 2 | 1 2.0|
Pelvis, Infiltration Cellular, | | |
Lymphocyte | 4 2 1 2 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 56 |
Infiltration Cellular, Lymphocyte | 1 2 | 20 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|
| 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + M + + M M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 4 |
Lymphoid Tissue, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 2 |
Congestion | 4 |
Eosinophilic Focus | 3 2 2 |
Fatty Change | 3 |
Mixed Cell Focus | 2 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 3 2 2 1 |
Centrilobular, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Granulomatous | 4 |
Fat, Inflammation, Chronic | 3 |
Fat, Inflammation, Suppurative | |
Fat, Necrosis, Coagulative | 3 2 4 |
Fat, Necrosis, Liquifactive | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperkeratosis | |
Hyperplasia, Squamous | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|
| 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cytomegaly | |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + I M I + + + + + + + + +|
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + +|
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Hyperplasia | |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 3 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Fibrosis | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|
| 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 3 |
Inflammation, Granulomatous | 3 |
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Angiectasis | 2 |
Congestion | 2 |
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 3 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Metacarpal, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 3 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|
| 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Retrobulbar, Infiltration Cellular, | |
Focal, Lymphocyte | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | |
Nephropathy | 1 2 1 1 1 |
Cortex, Cyst | |
Cortex, Cyst Multilocular | 2 |
Pelvis, Infiltration Cellular, | |
Lymphocyte | |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|
| 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M M + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I I +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Lymphoid Tissue, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 2 2 2 |
Congestion | |
Eosinophilic Focus | 2 2 |
Fatty Change | |
Mixed Cell Focus | 3 |
Necrosis, Coagulative | 3 3 |
Vacuolization Cytoplasmic | 3 2 3 1 |
Centrilobular, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | |
Fat, Inflammation, Chronic | 4 |
Fat, Inflammation, Suppurative | 4 |
Fat, Necrosis, Coagulative | 4 |
Fat, Necrosis, Liquifactive | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperkeratosis | 3 |
Hyperplasia, Squamous | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|
| 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 1 1 2 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 2 |
Cytomegaly | 2|
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + I + + + + + M M M + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Preputial Gland | + + + + |
Hyperplasia | 3 |
Inflammation, Suppurative | 4 |
Duct, Dilatation | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Fibrosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|
| 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | |
Congestion | |
Developmental Malformation | X |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Alopecia | 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Metacarpal, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|
| 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Retrobulbar, Infiltration Cellular, | |
Focal, Lymphocyte | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Glomerulosclerosis | 2 |
Infiltration Cellular, Lymphocyte | 3 3 1 |
Nephropathy | |
Cortex, Cyst | 2 |
Cortex, Cyst Multilocular | |
Pelvis, Infiltration Cellular, | |
Lymphocyte | 2 2 2 |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis, Coagulative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5| | |
| 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A + M + + + + A + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + + + + + + A + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + A + + | 57 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + A + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + + + + + A + + | 54 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + + + + + + A + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + A + + | 58 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Lymphoid Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + A + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | | 1 2.0|
Clear Cell Focus | | 4 2.0|
Congestion | | 1 4.0|
Eosinophilic Focus | 2 | 6 2.2|
Fatty Change | | 1 3.0|
Mixed Cell Focus | 2 | 4 2.3|
Necrosis, Coagulative | 1 | 3 2.3|
Vacuolization Cytoplasmic | 2 3 2 2 3 | 13 2.2|
Centrilobular, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Inflammation, Granulomatous | | 1 4.0|
Fat, Inflammation, Chronic | | 2 3.5|
Fat, Inflammation, Suppurative | | 1 4.0|
Fat, Necrosis, Coagulative | | 4 3.3|
Fat, Necrosis, Liquifactive | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + | 59 |
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + A + + | 59 |
Infiltration Cellular, Lymphocyte | 1 2 2 | 16 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + A + + + + + + A + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + + + + + A + + | 58 |
Hemorrhage | | 1 1.0|
Hyperkeratosis | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5| | |
| 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + A + + | 56 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + A + + | 59 |
Spindle Cell, Hyperplasia | 2 1 | 12 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + A + + | 59 |
Clear Cell Focus | 1 | 3 1.7|
Cytomegaly | | 1 2.0|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + A + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + | 59 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + M M M + + M + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I + + + + M + M + + | 52 |
Pars Distalis, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + | 58 |
Follicular Cell, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Mediastinum, Inflammation, | | |
Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + A + + | 59 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 16 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Duct, Dilatation | 4 3 3 3 4 3 | 14 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + A + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5| | |
| 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + A + + | 59 |
Dilatation | | 1 3.0|
Fibrosis | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + A + + | 59 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + M + + | 59 |
Deep Cervical, Hyperplasia, Plasma | | |
Cell | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + | 57 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + | 59 |
Congestion | | 2 2.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 5 2.8|
Inflammation, Granulomatous | | 1 3.0|
Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + | 59 |
Amyloid Deposition | | 1 2.0|
Angiectasis | | 1 2.0|
Congestion | | 1 2.0|
Developmental Malformation | | 1 |
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 4 2.5|
Hyperplasia, Lymphoid | 3 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + A + + | 57 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M + M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + A + + | 59 |
Alopecia | 2 | 3 2.3|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5| | |
| 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + A + + | 59 |
Metacarpal, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + A + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + A + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Retrobulbar, Infiltration Cellular, | | |
Focal, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A + + | 59 |
Ectopic Tissue | | 1 |
Glomerulosclerosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 | 5 2.2|
Nephropathy | 1 1 2 | 8 1.3|
Cortex, Cyst | | 1 2.0|
Cortex, Cyst Multilocular | | 1 2.0|
Pelvis, Infiltration Cellular, | | |
Lymphocyte | 2 1 | 5 1.8|
Renal Tubule, Mineralization | | 1 1.0|
Renal Tubule, Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + | 59 |
Infiltration Cellular, Lymphocyte | | 4 1.5|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|
| 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 |
Clear Cell Focus | 2 2 1 |
Eosinophilic Focus | 2 4 2 |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 3 |
Syncytial Alteration | 2 1 1 1 1 |
Vacuolization Cytoplasmic | |
Centrilobular, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | |
Necrosis, Coagulative | 4 |
Polyarteritis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + |
Spindle Cell, Hyperplasia | 2 3 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + |
Clear Cell Focus | |
Cytoplasmic Alteration | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|
| 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M M + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + A + M + + + + + + |
Fibrosis | |
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Follicular Cell, Cyst | 3 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
Granuloma | |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 4 3 4 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Congestion | |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hyperplasia, Lymphoid | |
Lymphocyte, Atrophy | |
__________________________________________________________________________|
Thymus | + I + + + + + + + + + M + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|
| 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Alopecia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Meninges, Fibrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Bronchiole, Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 |
Nephropathy | 1 2 1 |
Cortex, Cyst Multilocular | |
Renal Tubule, Necrosis, Coagulative | 2 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|
| 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
50 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | I A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 3 |
Eosinophilic Focus | 2 2 3 2 1 3 2|
Mixed Cell Focus | 1 2 |
Necrosis, Coagulative | |
Syncytial Alteration | |
Vacuolization Cytoplasmic | 2 |
Centrilobular, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Necrosis, Coagulative | |
Polyarteritis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 3 3 2 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cytoplasmic Alteration | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|
| 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
50 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + I + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + +|
Fibrosis | 3 |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Granuloma | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 4 3 4 4 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 |
Hyperplasia, Lymphoid | 3|
Lymphocyte, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M M M M|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|
| 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
50 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 1 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Meninges, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Nephropathy | 1 1 3 1 1|
Cortex, Cyst Multilocular | |
Renal Tubule, Necrosis, Coagulative | |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5| | |
| 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 54 |
Basophilic Focus | 3 | 4 2.3|
Clear Cell Focus | 2 2 2 | 7 2.0|
Eosinophilic Focus | 2 2 2 2 2 | 15 2.2|
Mixed Cell Focus | | 3 1.7|
Necrosis, Coagulative | | 1 3.0|
Syncytial Alteration | 1 1 | 7 1.1|
Vacuolization Cytoplasmic | | 1 2.0|
Centrilobular, Hypertrophy | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis, Coagulative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 50 |
Atrophy | 2 | 3 1.7|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Necrosis, Coagulative | | 1 4.0|
Polyarteritis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 2 2 2 2 | 19 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 49 |
Hyperkeratosis | | 2 2.0|
Hyperplasia, Squamous | 2 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5| | |
| 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 49 |
Spindle Cell, Hyperplasia | 1 2 | 12 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 49 |
Clear Cell Focus | 2 | 1 2.0|
Cytoplasmic Alteration | 2 | 1 2.0|
Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 50 |
Hyperplasia | 4 | 3 3.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + M | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + | 46 |
Fibrosis | | 1 3.0|
Pars Distalis, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Follicular Cell, Cyst | | 2 2.5|
Follicular Cell, Hyperplasia | 2 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + | 50 |
Granuloma | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 21 |
Inflammation, Suppurative | | 1 3.0|
Duct, Dilatation | 3 3 4 4 4 3 | 19 3.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 50 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 49 |
Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5| | |
| 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Lymphocyte, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M + M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 51 |
Alopecia | 1 | 5 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 50 |
Meninges, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 52 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Bronchiole, Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 3 | 4 2.3|
Nephropathy | 1 1 1 1 | 12 1.3|
Cortex, Cyst Multilocular | 2 | 1 2.0|
Renal Tubule, Necrosis, Coagulative | | 2 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5| | |
| 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|
DAY ON TEST | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|
| 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Edema | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | 3 2 1 |
Congestion | |
Eosinophilic Focus | 2 2 2 |
Inflammation, Suppurative | |
Mixed Cell Focus | |
Syncytial Alteration | 2 1 1 1 1 1 1 2 2 1 2 1 2 1|
Vacuolization Cytoplasmic | 2 3 2 |
Centrilobular, Hypertrophy | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration | |
Infiltration Cellular, Lymphocyte | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 2 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|
DAY ON TEST | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|
| 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + +|
Clear Cell Focus | 3 |
Cyst | 3 |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M|
Congestion | 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|
DAY ON TEST | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|
| 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | I M + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 1 2 |
Alveolus, Hemorrhage | |
Bronchiole, Dilatation, Focal | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | 1 1 |
Nephropathy | 3 1 |
Collecting Tubule, Necrosis, | |
Coagulative | 2 |
Cortex, Cyst | 2 |
Cortex, Cyst Multilocular | |
Renal Tubule, Necrosis, Coagulative | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|
| 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
100MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + I + + + + + + + + + + + + |
Periesophageal Tissue, Edema | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + M + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Clear Cell Focus | 2 2 1 2 |
Congestion | |
Eosinophilic Focus | 1 2 3 2 3 1 2 4 |
Inflammation, Suppurative | 2 |
Mixed Cell Focus | 2 |
Syncytial Alteration | 2 1 1 2 1 1 1 1 1 1 1 1 1 2 |
Vacuolization Cytoplasmic | 3 1 3 2 |
Centrilobular, Hypertrophy | 2 1 1 1 1 1 2 1 1 2 1 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Atrophy | |
Degeneration | |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Squamous | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|
| 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
100MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
Spindle Cell, Hyperplasia | 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Clear Cell Focus | |
Cyst | |
Cytoplasmic Alteration | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + M M + + + M + + + M + M M + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 4 4 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 3 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|
| 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
100MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hemorrhage | 2 |
Bronchiole, Dilatation, Focal | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Glomerulosclerosis | 3 |
Infiltration Cellular, Lymphocyte | 2 1 |
Nephropathy | 3 1 |
Collecting Tubule, Necrosis, | |
Coagulative | |
Cortex, Cyst | 2 |
Cortex, Cyst Multilocular | |
Renal Tubule, Necrosis, Coagulative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1| | |
| 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 49 |
Periesophageal Tissue, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + M | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A | 49 |
Hyperplasia, Lymphoid | 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A | 49 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + A | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + A | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A | 50 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 56 |
Basophilic Focus | | 2 2.0|
Clear Cell Focus | 2 | 8 1.9|
Congestion | 4 | 1 4.0|
Eosinophilic Focus | 4 4 | 13 2.5|
Inflammation, Suppurative | | 1 2.0|
Mixed Cell Focus | 3 3 2 | 4 2.5|
Syncytial Alteration | 1 1 1 2 1 1 1 2 2 1 1 | 39 1.3|
Vacuolization Cytoplasmic | 2 2 3 2 | 11 2.3|
Centrilobular, Hypertrophy | 2 2 2 2 2 2 2 | 23 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 50 |
Atrophy | 3 | 1 3.0|
Degeneration | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 | 14 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + A | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A | 50 |
Hyperplasia, Squamous | 2 3 | 3 2.7|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + A | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1| | |
| 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + M + + + + + + + + | 49 |
Spindle Cell, Hyperplasia | | 6 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + | 49 |
Clear Cell Focus | | 1 3.0|
Cyst | | 1 3.0|
Cytoplasmic Alteration | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M M | 40 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Follicular Cell, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 13 |
Inflammation, Suppurative | 4 | 1 4.0|
Duct, Dilatation | 4 4 4 | 12 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + | 50 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + | 50 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1| | |
| 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + I + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + I + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + M + + + + + + + + | 47 |
Congestion | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 51 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | M + + + I + + + + + + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M M M M M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 51 |
Alopecia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 51 |
Inflammation, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.5|
Alveolus, Hemorrhage | 2 | 2 2.0|
Bronchiole, Dilatation, Focal | 3 | 1 3.0|
Pleura, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1| | |
| 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
100MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 50 |
Glomerulosclerosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 4 1.3|
Nephropathy | 4 1 2 1 | 8 2.0|
Collecting Tubule, Necrosis, | | |
Coagulative | | 1 2.0|
Cortex, Cyst | 2 2 | 4 2.0|
Cortex, Cyst Multilocular | 4 | 1 4.0|
Renal Tubule, Necrosis, Coagulative | 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|
| 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + A + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + I M + + + + + + M + + + M + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Lymphoid Tissue, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 |
Basophilic Focus | 2 |
Clear Cell Focus | 2 2 |
Congestion | 4 4 |
Developmental Malformation | |
Eosinophilic Focus | 3 X 3 2 4 2 |
Fatty Change | |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 3 3 3 |
Syncytial Alteration | 2 2 2 2 2 2 2 2 2 2 1 2 1 1 2 2 2 2 2 2 2|
Vacuolization Cytoplasmic | 1 2 2 |
Centrilobular, Hypertrophy | 3 3 2 2 2 1 2 2 1 1 2 2 2 2 1 2 2 2 1 2|
__________________________________________________________________________|
Mesentery | + |
Fat, Hemorrhage | 2 |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Infiltration Cellular, Lymphocyte | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|
| 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M M + + M M + M + + + M + I +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia, | |
Papillary | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Duct, Dilatation | 4 4 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | A + M + + + + + + + + + + + + + + + M + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|
| 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + I M I + + M + + + + + I + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Hemorrhage | |
Inflammation, Chronic Active | 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchiole, Epithelium, Hyperplasia | 2 |
Bronchiole, Epithelium, Necrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | |
Lumen, Inflammation, Suppurative | 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | 1 3 2 |
Nephropathy | 2 |
Collecting Tubule, Necrosis, | |
Coagulative | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|
| 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulus, Inflammation, Chronic | |
Pelvis, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Urethra | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|
| 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + A M A + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + A + + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + A A A + + + + + + A|
Inflammation, Chronic | |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + A A + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + A A A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + A A A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + A A A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + A A A + + + + + + A|
Hyperplasia, Lymphoid | |
Lymphoid Tissue, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A A A + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | 2 2 1 1 |
Congestion | 3 4 4 4|
Developmental Malformation | |
Eosinophilic Focus | 4 2 4 2 |
Fatty Change | |
Mixed Cell Focus | |
Necrosis, Coagulative | 4 4 2 3|
Syncytial Alteration | 2 2 2 2 1 2 2 2 2 2 2 3 3 2 2 2 2 2|
Vacuolization Cytoplasmic | 3 |
Centrilobular, Hypertrophy | 2 2 1 1 2 1 1 3 2 2 1 2 1 2 2|
__________________________________________________________________________|
Mesentery | + |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 2 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + A A + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A A + + + + + + + A|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + A A + + + + + + + A|
Infiltration Cellular, Lymphocyte | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|
| 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Clear Cell Focus | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + I + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | |
Follicular Cell, Hyperplasia, | |
Papillary | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + A + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + M + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|
| 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + I + + M + + + + + A|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Alopecia | |
Hemorrhage | |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 3 2 2|
Bronchiole, Epithelium, Hyperplasia | |
Bronchiole, Epithelium, Necrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | |
Lumen, Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Glomerulosclerosis | 3 |
Infiltration Cellular, Lymphocyte | 1 |
Nephropathy | |
Collecting Tubule, Necrosis, | |
Coagulative | 2 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
_____________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|
| 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Glomerulus, Inflammation, Chronic | |
Pelvis, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + A + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3| | |
| 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + M + + A + + + + + M + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + A A + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + A A + + + + + + | 51 |
Inflammation, Chronic | | 1 4.0|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + A A + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + A A + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + A A + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + A A + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + A A + + + + + + | 51 |
Hyperplasia, Lymphoid | | 1 3.0|
Lymphoid Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + A A + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis | | 2 3.5|
Basophilic Focus | 2 2 | 3 2.0|
Clear Cell Focus | 2 2 2 2 2 | 11 1.8|
Congestion | 4 | 7 3.9|
Developmental Malformation | X | 1 |
Eosinophilic Focus | 3 3 1 3 2 | 15 2.7|
Fatty Change | 2 | 1 2.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Coagulative | 4 | 8 3.3|
Syncytial Alteration | 2 3 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 | 56 1.9|
Vacuolization Cytoplasmic | 2 2 | 6 2.0|
Centrilobular, Hypertrophy | 2 1 2 2 3 2 3 3 2 1 2 2 1 2 1 3 1 | 52 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Hemorrhage | | 1 2.0|
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Coagulative | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 59 |
Atrophy | | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 1 1 2 | 21 1.6|
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3| | |
| 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + A + + + + + + + | 53 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | 1 | 4 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 59 |
Spindle Cell, Hyperplasia | 2 2 1 2 | 10 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 59 |
Basophilic Focus | | 1 3.0|
Clear Cell Focus | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + + + M M + + + + M + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + M + + + + + + + | 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 60 |
Follicular Cell, Cyst | 3 | 1 3.0|
Follicular Cell, Hyperplasia | 2 | 2 2.0|
Follicular Cell, Hyperplasia, | | |
Papillary | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 9 |
Duct, Dilatation | 4 4 | 7 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 3 1.7|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3| | |
| 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + | 54 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + | 56 |
Congestion | 2 | 3 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + M + + + + | 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 60 |
Alopecia | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 60 |
Congestion | | 2 3.0|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 5 2.2|
Bronchiole, Epithelium, Hyperplasia | | 1 2.0|
Bronchiole, Epithelium, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 60 |
Fungus | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Lumen, Inflammation, Suppurative | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05090-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 12:04:13
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3| | |
| 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Inflammation, Chronic, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + + + + | 58 |
Fibrosis | | 1 2.0|
Glomerulosclerosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 | 5 1.8|
Nephropathy | 2 2 | 3 2.0|
Collecting Tubule, Necrosis, | | |
Coagulative | | 1 2.0|
Glomerulus, Inflammation, Chronic | 3 | 1 3.0|
Pelvis, Infiltration Cellular, | | |
Lymphocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + | 57 |
Infiltration Cellular, Lymphocyte | 1 2 2 | 9 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
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---------- END OF REPORT ----------
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