TDMS Study 05090-01 Pathology Tables
NTP Experiment-Test: 05090-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC COUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:54:22
39 WEEK STOP ANIMALS
Facility: American Biogenics Corp.
Chemical CAS #: 000091645
Lock Date: None
Cage Range: All
Reasons For Removal: 25004 Dead 25014 Gavage Death
25003 Moribund 25006 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 011 100MG/KG 39 STOP
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05090-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC COUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:54:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2| | |
| 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
39 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + A + + + + + + A + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + A + + + + + + A + + + | 17 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + A + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + M + + + M + + + + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + A + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + A + + + + + + + + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + A + + + + + + A + + + | 17 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + M + + + + + + A + + + | 17 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X X X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 7 |
Mesothelioma NOS | X | 1 |
Fat, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + | 19 |
Adenoma | X | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + A + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + | 18 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Fibrosarcoma | X | 1 |
Leukemia Mononuclear | X X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05090-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC COUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:54:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2| | |
| 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
39 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Pheochromocytoma Benign | X X X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + | 19 |
Adenoma | X | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + | 19 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
Pars Distalis, Adenoma | X X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Mesothelioma NOS | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
Mesothelioma NOS | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + | 19 |
Adenoma | X | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X | 18 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 05090-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC COUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:54:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2| | |
| 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
39 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + M + + + + + + | 19 |
Leukemia Mononuclear | X X X X X | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Fibroadenoma | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + A + + + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X X X | 4 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 05090-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC COUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:54:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2| | |
| 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
39 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Mesothelioma NOS | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
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