TDMS Study 05090-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
COUMARIN
NTP Experiment-Test: 05090-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/12/94
Route: GAVAGE Time: 03:12:33
Facility: American Biogenics Corp.
Chemical CAS #: 000091645
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 14 7 7 14
Dead 5 4 2 6
Gavage Death 2 1 5
Survivors
Terminal Sacrifice 29 38 35 30
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (56) (47) (49) (55)
Intestine Large, Colon (57) (48) (49) (57)
Intestine Large, Rectum (58) (49) (48) (58)
Intestine Small, Ileum (56) (47) (48) (56)
Intestine Small, Jejunum (56) (48) (48) (56)
Leiomyoma 1 (2%)
Liver (60) (58) (58) (60)
Mesentery (3) (8) (10) (7)
Sarcoma 1 (14%)
Pancreas (59) (49) (48) (56)
Pharynx (2)
Squamous Cell Papilloma 2 (100%)
Salivary Glands (60) (50) (50) (60)
Stomach, Forestomach (58) (50) (50) (58)
Squamous Cell Papilloma 1 (2%) 3 (6%) 1 (2%)
Stomach, Glandular (58) (50) (49) (57)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (50) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (50) (48) (60)
Adenoma 1 (2%)
Adrenal Gland, Medulla (60) (50) (48) (59)
Pheochromocytoma Benign 3 (5%) 2 (4%) 2 (4%) 1 (2%)
Page 2
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (59) (49) (48) (57)
Adenoma 1 (2%) 1 (2%) 2 (4%)
Pituitary Gland (58) (48) (48) (59)
Pars Distalis, Adenocarcinoma 1 (2%)
Pars Distalis, Adenoma 30 (52%) 26 (54%) 23 (48%) 28 (47%)
Thyroid Gland (59) (50) (49) (59)
C-Cell, Adenoma 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1)
Fibroma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (47) (49) (59)
Adenoma 6 (13%) 2 (3%)
Carcinoma 1 (2%) 1 (2%) 2 (3%)
Ovary (60) (50) (50) (59)
Granulosa-Theca Tumor Benign 1 (2%)
Oviduct (1)
Uterus (60) (51) (52) (59)
Polyp 8 (13%) 14 (27%) 6 (12%) 7 (12%)
Sarcoma 1 (2%)
Vagina (1) (1) (4)
Leiomyoma 1 (100%)
Leiomyosarcoma 1 (25%)
Sarcoma 1 (25%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (50) (49) (59)
Lymph Node (59) (50) (50) (59)
Lymph Node, Mandibular (59) (47) (48) (57)
Lymph Node, Mesenteric (57) (49) (49) (59)
Spleen (59) (51) (49) (59)
Thymus (58) (48) (49) (56)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (50) (50) (59)
Adenocarcinoma 1 (2%) 1 (2%)
Adenoma 1 (2%) 2 (4%)
Fibroadenoma 17 (29%) 24 (48%) 22 (44%) 11 (19%)
Fibrosarcoma 1 (2%)
Skin (60) (50) (51) (60)
Lipoma 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (50) (50) (60)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (50) (59)
Meninges, Meningioma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (49) (50) (60)
Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Squamous Cell Papilloma 1 (100%)
Eye (1) (4) (1) (1)
Squamous Cell Papilloma 1 (100%)
Zymbal's Gland (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (58) (60) (59)
Lipoma 1 (2%)
Sarcoma 1 (2%)
Renal Tubule, Adenoma 2 (3%)
Page 4
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Urinary Bladder (59) (49) (49) (57)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 6 (10%) 5 (8%) 6 (10%) 4 (7%)
Mesothelioma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 46 42 45
Total Primary Neoplasms 76 93 73 78
Total Animals with Benign Neoplasms 38 45 38 42
Total Benign Neoplasms 65 86 62 63
Total Animals with Malignant Neoplasms 10 7 10 11
Total Malignant Neoplasms 10 7 10 15
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 25 MG/KG 50 MG/KG 100MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 20 10 60 60 60
Scheduled Sacrifice 10 17 7 10 9 10
Early Deaths
Moribund 14 31 33 31
Gavage Death 2 2 3 3 2 2
Dead 6 1 7 13 17
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 28 9 2
Animals Examined Microscopically 59 20 10 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (55) (2) (10) (48) (42) (54)
Adenoma, Papillary 1 (2%)
Intestine Small (55) (2) (9) (47) (47) (54)
Adenocarcinoma 1 (2%)
Intestine Small, Duodenum (56) (2) (9) (48) (48) (56)
Fibrosarcoma, Metastatic 1 (2%)
Intestine Small, Ileum (55) (1) (9) (46) (43) (52)
Fibrosarcoma, Metastatic 1 (2%)
Intestine Small, Jejunum (55) (2) (9) (47) (45) (54)
Fibrosarcoma, Metastatic 1 (2%)
Liver (59) (20) (10) (60) (60) (60)
Fibrosarcoma, Metastatic 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 2 (3%)
Hepatocellular Adenoma 1 (2%)
Mesentery (21) (1) (3) (12) (18) (7)
Fibrosarcoma, Metastatic 1 (5%)
Pancreas (57) (20) (9) (49) (50) (59)
Adenoma 1 (2%) 2 (4%) 3 (6%)
Fibrosarcoma, Metastatic 1 (2%)
Pharynx (1) (1) (2)
Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (100%) 1 (100%) 1 (50%)
Stomach, Forestomach (58) (20) (10) (51) (51) (60)
Squamous Cell Papilloma 2 (4%) 2 (3%)
Stomach, Glandular (57) (20) (10) (48) (49) (60)
Fibrosarcoma, Metastatic 1 (2%)
Tooth (1)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 25 MG/KG 50 MG/KG 100MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (20) (10) (49) (51) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (19) (10) (50) (50) (60)
Adrenal Gland, Medulla (59) (19) (10) (50) (50) (60)
Pheochromocytoma Benign 9 (15%) 5 (10%) 5 (10%)
Islets, Pancreatic (57) (3) (9) (50) (50) (59)
Adenoma 4 (7%) 1 (2%) 2 (4%)
Parathyroid Gland (51) (19) (10) (47) (49) (57)
Adenoma 1 (2%)
Pituitary Gland (58) (20) (10) (48) (51) (60)
Pars Distalis, Adenoma 20 (34%) 1 (10%) 12 (25%) 18 (35%) 8 (13%)
Thyroid Gland (57) (20) (10) (49) (49) (60)
C-Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (5%) 3 (6%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1) (1)
Adenocarcinoma 1 (50%)
Fibrosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (55) (20) (10) (50) (46) (60)
Preputial Gland (55) (3) (10) (49) (50) (56)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Prostate (55) (20) (10) (50) (50) (59)
Seminal Vesicle (55) (20) (10) (50) (50) (59)
Fibrosarcoma, Metastatic 1 (2%)
Testes (55) (20) (10) (58) (54) (60)
Interstitial Cell, Adenoma 46 (84%) 7 (70%) 52 (90%) 50 (93%) 54 (90%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 25 MG/KG 50 MG/KG 100MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1)
Bone Marrow (58) (3) (10) (50) (50) (60)
Lymph Node (59) (20) (10) (50) (49) (58)
Lymph Node, Mandibular (57) (20) (10) (47) (48) (58)
Lymph Node, Mesenteric (53) (4) (10) (50) (48) (60)
Spleen (58) (20) (10) (50) (51) (60)
Hemangiosarcoma 1 (2%)
Thymus (57) (3) (10) (48) (48) (56)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (54) (2) (10) (46) (44) (54)
Adenoma 1 (2%)
Fibroadenoma 4 (7%) 1 (2%) 2 (5%)
Skin (59) (4) (10) (50) (51) (60)
Basal Cell Adenoma 1 (2%)
Fibroma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 3 (6%) 1 (2%)
Face, Squamous Cell Papilloma 1 (2%)
Pinna, Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (3%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (3) (10) (50) (51) (60)
Chordoma 1 (2%)
Skeletal Muscle (1) (2) (1)
Fibrosarcoma, Metastatic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57) (20) (9) (50) (49) (59)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 25 MG/KG 50 MG/KG 100MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (20) (10) (49) (51) (60)
Adenocarcinoma, Metastatic 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Fibrosarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3) (1)
Fibroma 1 (33%)
Squamous Cell Papilloma 1 (33%) 1 (100%)
Eye (4) (1)
Squamous Cell Papilloma 1 (25%)
Zymbal's Gland (2) (1) (1)
Carcinoma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (19) (10) (60) (60) (60)
Adenoma 1 (2%)
Fibrosarcoma, Metastatic 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 3 (5%) 1 (2%)
Urethra (1)
Urinary Bladder (55) (20) (10) (49) (50) (59)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(59) *(20) *(10) *(60) *(60) *(60)
Leukemia Mononuclear 8 (14%) 10 (17%) 1 (2%) 1 (2%)
Mesothelioma NOS 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 25 MG/KG 50 MG/KG 100MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 55 1 8 55 55 57
Total Primary Neoplasms 115 1 8 108 97 76
Total Animals with Benign Neoplasms 54 1 8 55 54 56
Total Benign Neoplasms 95 1 8 94 92 70
Total Animals with Malignant Neoplasms 16 13 4 4
Total Malignant Neoplasms 19 14 4 5
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 11 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 3 1 3
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 100MG/KG 100MG/KG 100MG/KG 100MG/KG
39 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 20 20 10 20
Scheduled Sacrifice 18 10
Early Deaths
Gavage Death 2 1 3
Moribund 6 13
Dead 4 2
Survivors
Terminal Sacrifice 8 2
Dead 1
Animals Examined Microscopically 20 20 10 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (2) (17) (10) (20)
Intestine Large, Colon (2) (18) (10) (20)
Intestine Large, Rectum (2) (18) (10) (20)
Intestine Small, Duodenum (2) (18) (10) (20)
Intestine Small, Ileum (2) (17) (10) (20)
Intestine Small, Jejunum (2) (17) (10) (20)
Liver (20) (20) (10) (20)
Hepatocellular Adenoma 1 (5%)
Mesentery (1) (7) (1) (4)
Pancreas (20) (19) (10) (20)
Adenoma 1 (5%)
Stomach, Forestomach (20) (19) (10) (19)
Stomach, Glandular (20) (18) (10) (20)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (20) (10) (20)
Fibrosarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (20) (20) (10) (20)
Adrenal Gland, Medulla (20) (20) (10) (20)
Pheochromocytoma Benign 4 (20%) 1 (5%)
Islets, Pancreatic (2) (19) (10) (20)
Page 12
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 100MG/KG 100MG/KG 100MG/KG 100MG/KG
39 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Adenoma 1 (5%)
Parathyroid Gland (20) (19) (10) (18)
Adenoma 1 (5%)
Pituitary Gland (20) (20) (10) (20)
Pars Distalis, Adenoma 4 (20%) 2 (20%) 5 (25%)
Thyroid Gland (20) (20) (10) (20)
Follicular Cell, Carcinoma 1 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (20) (20) (10) (20)
Preputial Gland (3) (19) (10) (20)
Adenoma 1 (5%)
Carcinoma 1 (5%)
Seminal Vesicle (20) (20) (10) (20)
Testes (20) (20) (10) (20)
Interstitial Cell, Adenoma 1 (5%) 18 (90%) 10 (100%) 15 (75%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (2) (19) (10) (20)
Lymph Node (20) (20) (10) (20)
Lymph Node, Mandibular (20) (20) (9) (20)
Lymph Node, Mesenteric (3) (20) (10) (20)
Spleen (20) (19) (10) (20)
Thymus (2) (20) (10) (19)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (2) (20) (10) (16)
Fibroadenoma 2 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2) (20) (10) (20)
Lumbar, Vertebra, Sarcoma 1 (5%)
Skeletal Muscle (1)
Back, Sarcoma 1 (100%)
Page 13
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 100MG/KG 100MG/KG 100MG/KG 100MG/KG
39 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (19) (10) (20)
Squamous Cell Carcinoma, Metastatic 1 (5%)
Spinal Cord (2) (1)
Meninges, Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (20) (20) (10) (20)
Squamous Cell Carcinoma 1 (5%)
Nose (2) (20) (10) (20)
Polyp 1 (5%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Basal Cell Adenoma 1 (100%)
Zymbal's Gland (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (20) (10) (20)
Renal Tubule, Adenoma 1 (5%) 2 (10%)
Renal Tubule, Oncocytoma Benign 2 (10%)
Urinary Bladder (20) (20) (10) (20)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(20) *(20) *(10) *(20)
Leukemia Mononuclear 5 (25%) 4 (20%)
Mesothelioma NOS 1 (5%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 14
NTP Experiment-Test: 05090-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COUMARIN Date: 09/12/94
Route: GAVAGE Time: 03:12:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 100MG/KG 100MG/KG 100MG/KG 100MG/KG
39 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 18 10 17
Total Primary Neoplasms 1 43 12 37
Total Animals with Benign Neoplasms 1 18 10 16
Total Benign Neoplasms 1 34 12 28
Total Animals with Malignant Neoplasms 8 7
Total Malignant Neoplasms 8 9
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 3
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 15
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------