TDMS Study 05090-01 Pathology Tables
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
Facility: American Biogenics Corp.
Chemical CAS #: 000091645
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 4| 7| 0| 7| 7| 7| 7| 4| 4| 7| 6| 4| 7| 1| 3| 7| 7| 6| 4| 7|
DAY ON TEST | 3| 8| 6| 3| 1| 5| 2| 9| 3| 3| 1| 3| 5| 9| 0| 2| 3| 3| 8| 5| 3| 2| 6| 5| 3|
| 2| 0| 2| 3| 9| 5| 9| 2| 4| 3| 2| 2| 6| 1| 8| 4| 5| 2| 4| 6| 3| 9| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Developmental Malformation | X X X X |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 1 1 1 2|
Inflammation, Suppurative | 4 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 2 1 |
Bile Duct, Hyperplasia | 1 1 1 2 1 3 1 3 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + +|
Developmental Malformation | |
Inflammation, Chronic | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + +|
Mineralization | 4 |
Ulcer | 3 3 3 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 2 1 2 2 |
Fibrosis | |
Mineralization | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 4| 7| 0| 7| 7| 7| 7| 4| 4| 7| 6| 4| 7| 1| 3| 7| 7| 6| 4| 7|
DAY ON TEST | 3| 8| 6| 3| 1| 5| 2| 9| 3| 3| 1| 3| 5| 9| 0| 2| 3| 3| 8| 5| 3| 2| 6| 5| 3|
| 2| 0| 2| 3| 9| 5| 9| 2| 4| 3| 2| 2| 6| 1| 8| 4| 5| 2| 4| 6| 3| 9| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Clear Cell Focus | |
Hemorrhage | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + A + + + + + +|
Pars Distalis, Cyst | 2 3 |
Pars Distalis, Pigmentation, Melanin | |
Pars Intermedia, Congestion | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
C-Cell, Hyperplasia | 4 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + M + + + + + +|
Inflammation, Suppurative | 4 4 3|
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpus Luteum, Cyst | 3 |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 3 3 2 4 |
Hyperplasia, Cystic | |
Necrosis, Coagulative | 3 |
Cervix, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + A + + + + + +|
Pancreatic, Inflammation, Suppurative| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 4| 7| 0| 7| 7| 7| 7| 4| 4| 7| 6| 4| 7| 1| 3| 7| 7| 6| 4| 7|
DAY ON TEST | 3| 8| 6| 3| 1| 5| 2| 9| 3| 3| 1| 3| 5| 9| 0| 2| 3| 3| 8| 5| 3| 2| 6| 5| 3|
| 2| 0| 2| 3| 9| 5| 9| 2| 4| 3| 2| 2| 6| 1| 8| 4| 5| 2| 4| 6| 3| 9| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Galactocele | X 3 4 |
Hyperplasia, Glandular | |
Inflammation | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Atypia Cellular | 4 |
Cerebrum, Hemorrhage | |
Cerebrum, Mineralization | 2 |
Hypothalamus, Compression | |
Hypothalamus, Developmental | |
Malformation | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 1 |
Inflammation | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +|
Mineralization | 1|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 4| 7| 0| 7| 7| 7| 7| 4| 4| 7| 6| 4| 7| 1| 3| 7| 7| 6| 4| 7|
DAY ON TEST | 3| 8| 6| 3| 1| 5| 2| 9| 3| 3| 1| 3| 5| 9| 0| 2| 3| 3| 8| 5| 3| 2| 6| 5| 3|
| 2| 0| 2| 3| 9| 5| 9| 2| 4| 3| 2| 2| 6| 1| 8| 4| 5| 2| 4| 6| 3| 9| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 6| 4| 4| 6| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 5| 3| 3| 0| 3| 3| 5| 1| 9| 3| 3| 9| 5| 5| 5| 2| 3| 5| 5|
| 4| 2| 7| 4| 4| 2| 6| 2| 4| 0| 3| 3| 6| 4| 3| 3| 4| 9| 5| 5| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Developmental Malformation | |
Fatty Change | 1 3 2 3 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 1 2 2 1 1 2 1 1 1 |
Inflammation, Suppurative | |
Mixed Cell Focus | X X X |
Necrosis, Coagulative | 4 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Coagulative | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Inflammation, Chronic | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
Hyperplasia | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 1 2 2 2 2 2 |
Fibrosis | 2 2 |
Mineralization | |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 6| 4| 4| 6| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 5| 3| 3| 0| 3| 3| 5| 1| 9| 3| 3| 9| 5| 5| 5| 2| 3| 5| 5|
| 4| 2| 7| 4| 4| 2| 6| 2| 4| 0| 3| 3| 6| 4| 3| 3| 4| 9| 5| 5| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Clear Cell Focus | 2 2 3 |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 3 X |
Pars Distalis, Pigmentation, Melanin | 3 |
Pars Intermedia, Congestion | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpus Luteum, Cyst | 2 |
Follicle, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 2 |
Hyperplasia, Cystic | 2 3 2 |
Necrosis, Coagulative | |
Cervix, Inflammation, Suppurative | |
__________________________________________________________________________|
Vagina | + |
Cyst | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Inflammation, Suppurative| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 6| 4| 4| 6| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 5| 3| 3| 0| 3| 3| 5| 1| 9| 3| 3| 9| 5| 5| 5| 2| 3| 5| 5|
| 4| 2| 7| 4| 4| 2| 6| 2| 4| 0| 3| 3| 6| 4| 3| 3| 4| 9| 5| 5| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 |
Hyperplasia, Glandular | 2 |
Inflammation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Atypia Cellular | |
Cerebrum, Hemorrhage | |
Cerebrum, Mineralization | |
Hypothalamus, Compression | |
Hypothalamus, Developmental | |
Malformation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | |
Inflammation | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 6| 4| 4| 6| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 5| 3| 3| 0| 3| 3| 5| 1| 9| 3| 3| 9| 5| 5| 5| 2| 3| 5| 5|
| 4| 2| 7| 4| 4| 2| 6| 2| 4| 0| 3| 3| 6| 4| 3| 3| 4| 9| 5| 5| 9| 9| 2| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 1| 3| 2| 4| 3| 3| 3| 5| | |
| 2| 4| 4| 2| 9| 9| 3| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X X | 39 |
Developmental Malformation | X X | 6 |
Fatty Change | | 5 2.4|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | 3 2 2 2 2 | 19 1.6|
Inflammation, Suppurative | | 1 4.0|
Mixed Cell Focus | X X | 6 |
Necrosis, Coagulative | | 3 2.3|
Bile Duct, Hyperplasia | 1 2 1 1 1 | 27 1.2|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis, Coagulative | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy | | 6 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Developmental Malformation | | 1 |
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Mineralization | | 1 4.0|
Ulcer | | 4 2.8|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 1| 3| 2| 4| 3| 3| 3| 5| | |
| 2| 4| 4| 2| 9| 9| 3| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 2 2 2 2 | 27 1.8|
Fibrosis | | 2 2.0|
Mineralization | | 1 2.0|
Thrombosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Clear Cell Focus | | 3 2.3|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | | 5 2.5|
Pars Distalis, Pigmentation, Melanin | | 1 3.0|
Pars Intermedia, Congestion | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 6 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Inflammation, Suppurative | | 4 3.8|
Duct, Dilatation | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Corpus Luteum, Cyst | | 2 2.5|
Follicle, Cyst | 3 2 4 | 4 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | | 9 2.6|
Hyperplasia, Cystic | | 3 2.3|
Necrosis, Coagulative | | 1 3.0|
Cervix, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 1| 3| 2| 4| 3| 3| 3| 5| | |
| 2| 4| 4| 2| 9| 9| 3| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Pancreatic, Inflammation, Suppurative| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Galactocele | X | 6 3.0|
Hyperplasia, Glandular | | 1 2.0|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Cerebrum, Atypia Cellular | | 1 4.0|
Cerebrum, Hemorrhage | 3 | 1 3.0|
Cerebrum, Mineralization | | 1 2.0|
Hypothalamus, Compression | 3 | 1 3.0|
Hypothalamus, Developmental | | |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | | 2 2.5|
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 1| 3| 2| 4| 3| 3| 3| 5| | |
| 2| 4| 4| 2| 9| 9| 3| 4| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 3.0|
Inflammation, Suppurative | 2 | 4 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 4 | 1 4.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Mineralization | | 2 2.0|
Nephropathy | 2 1 1 3 2 1 | 38 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 4| 4| 4| 4| 7| 7| 7| 4|
DAY ON TEST | 5| 3| 3| 5| 3| 9| 3| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 3| 5|
| 5| 2| 3| 6| 1| 3| 4| 9| 4| 2| 9| 2| 4| 3| 3| 4| 2| 6| 6| 9| 6| 4| 3| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | |
Developmental Malformation | X |
Eosinophilic Focus | |
Inflammation, Chronic | 1 1 2 1 1 3 1 1 1 2 1 |
Necrosis, Coagulative | 1 1 |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 2 1 2 1 1 1 3 1|
__________________________________________________________________________|
Mesentery | + + +|
Fat, Cyst | |
Fat, Inflammation, Chronic | |
Fat, Mineralization | 2 2|
Fat, Necrosis, Coagulative | 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Clear Cell Focus | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 4| 4| 4| 4| 7| 7| 7| 4|
DAY ON TEST | 5| 3| 3| 5| 3| 9| 3| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 3| 5|
| 5| 2| 3| 6| 1| 3| 4| 9| 4| 2| 9| 2| 4| 3| 3| 4| 2| 6| 6| 9| 6| 4| 3| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + I |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Congestion | 1 |
Pars Distalis, Cyst | 2 2 3 2 X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + |
Inflammation, Suppurative | 4 4 4 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 4 3|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 3 |
Hyperplasia, Cystic | 2 |
Cervix, Cyst | 3 |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Anisocytosis | 3 |
Monocytosis | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M + + + + + + + + + + + |
Hyperplasia, Macrophage | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | 4|
Hyperplasia, Lymphoid | 3 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + |
Galactocele | |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 4| 4| 4| 4| 7| 7| 7| 4|
DAY ON TEST | 5| 3| 3| 5| 3| 9| 3| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 3| 5|
| 5| 2| 3| 6| 1| 3| 4| 9| 4| 2| 9| 2| 4| 3| 3| 4| 2| 6| 6| 9| 6| 4| 3| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hypothalamus, Compression | 3 |
Hypothalamus, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Inflammation | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | |
Nephropathy | 1 1 1 1 3 1 1 2 2 1 1 1 2 1 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 7| 2| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 4| 2| 3| 5| 3| 3| 5| 3| 2| 3| 3| 3| 4|
| 9| 2| 9| 3| 4| 4| 2| 2| 5| 3| 3| 3| 5| 9| 2| 5| 3| 2| 4| 2| 9| 4| 3| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Developmental Malformation | X |
Eosinophilic Focus | |
Inflammation, Chronic | 1 1 1 1 1 1 1 3 2 |
Necrosis, Coagulative | 1 |
Bile Duct, Hyperplasia | 1 1 1 2 2 1 2 1 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Cyst | |
Fat, Inflammation, Chronic | |
Fat, Mineralization | |
Fat, Necrosis, Coagulative | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + +|
Hyperkeratosis | 2 3 |
Hyperplasia, Squamous | |
Inflammation, Suppurative | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 7| 2| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 4| 2| 3| 5| 3| 3| 5| 3| 2| 3| 3| 3| 4|
| 9| 2| 9| 3| 4| 4| 2| 2| 5| 3| 3| 3| 5| 9| 2| 5| 3| 2| 4| 2| 9| 4| 3| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + A + + + + + + + + + + +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + M + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 4 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Hyperplasia, Cystic | 3 3 |
Cervix, Cyst | |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Anisocytosis | |
Monocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 3 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| 7| 2| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 4| 2| 3| 5| 3| 3| 5| 3| 2| 3| 3| 3| 4|
| 9| 2| 9| 3| 4| 4| 2| 2| 5| 3| 3| 3| 5| 9| 2| 5| 3| 2| 4| 2| 9| 4| 3| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
Hypothalamus, Hemorrhage | 3 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation | 2 2 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | A + |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 3 1 2 1 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 1| 3| 5| 3| | |
| 2| 4| 4| 2| 4| 6| 3| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 58 |
Basophilic Focus | X X X X X | 33 |
Clear Cell Focus | | 1 |
Developmental Malformation | X X | 4 |
Eosinophilic Focus | X | 1 |
Inflammation, Chronic | 2 1 1 1 | 24 1.3|
Necrosis, Coagulative | | 3 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 | 30 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Fat, Cyst | 4 | 1 4.0|
Fat, Inflammation, Chronic | 4 | 1 4.0|
Fat, Mineralization | | 2 2.0|
Fat, Necrosis, Coagulative | 3 | 5 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Hyperkeratosis | | 2 2.5|
Hyperplasia, Squamous | 2 3 | 2 2.5|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 1 2 2 | 20 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 1| 3| 5| 3| | |
| 2| 4| 4| 2| 4| 6| 3| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Clear Cell Focus | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
Basophilic Focus | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + A + + + | 48 |
Pars Distalis, Congestion | | 1 1.0|
Pars Distalis, Cyst | | 8 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Hyperplasia | 2 2 | 5 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 47 |
Inflammation, Suppurative | 2 3 4 | 10 3.5|
Duct, Dilatation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 50 |
Follicle, Cyst | 3 | 3 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 51 |
Hydrometra | 3 | 5 3.0|
Hyperplasia, Cystic | | 3 2.7|
Cervix, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Anisocytosis | | 1 3.0|
Monocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + | 47 |
Hyperplasia, Macrophage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
Congestion | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 1| 3| 5| 3| | |
| 2| 4| 4| 2| 4| 6| 3| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 51 |
Congestion | | 2 3.0|
Hyperplasia, Lymphoid | | 2 2.5|
Pigmentation, Hemosiderin | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 50 |
Galactocele | 3 4 4 | 4 3.7|
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Cyst Epithelial Inclusion | X X | 2 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hypothalamus, Compression | 3 | 2 3.0|
Hypothalamus, Hemorrhage | | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 49 |
Congestion | | 2 2.0|
Inflammation | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Lens, Cataract | | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Mineralization | | 1 2.0|
Nephropathy | 1 2 1 1 1 1 2 3 1 2 | 52 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 1| 3| 5| 3| | |
| 2| 4| 4| 2| 4| 6| 3| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 7| 4| 7| 7| 7| 4| 1| 7| 6| 7| 6|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 0| 2| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 5| 8| 3| 3| 3| 0|
| 6| 6| 3| 5| 4| 4| 5| 9| 9| 4| 2| 7| 2| 2| 3| 6| 3| 2| 3| 6| 9| 3| 7| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Developmental Malformation | X X |
Eosinophilic Focus | X |
Fatty Change | 2 2 1 2 2 1 |
Fibrosis | |
Inflammation, Chronic | 2 1 2 3 2 3 2 2 1 2 |
Inflammation, Suppurative | 2 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 |
Necrosis | 1 |
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 2|
Hepatocyte, Degeneration, Granular | 1 2 2 |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Inflammation, Chronic | 3 |
Fat, Mineralization | |
Fat, Necrosis, Coagulative | 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + A + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Chronic | |
Ulcer | 4 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 3|
Fibrosis | 2 3|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 7| 4| 7| 7| 7| 4| 1| 7| 6| 7| 6|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 0| 2| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 5| 8| 3| 3| 3| 0|
| 6| 6| 3| 5| 4| 4| 5| 9| 9| 4| 2| 7| 2| 2| 3| 6| 3| 2| 3| 6| 9| 3| 7| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + + + + + A + +|
Clear Cell Focus | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + A + + + + + + A + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + M + + + M + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + A + + + + + + A + +|
Pars Distalis, Cyst | 3 X 3|
Pars Nervosa, Cyst Multilocular | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Suppurative | 4 4 4 4 4 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Corpus Luteum, Cyst | |
Follicle, Cyst | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + A + + + + + + + + +|
Hydrometra | 2 3 3 |
Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Hemorrhage, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 7| 4| 7| 7| 7| 4| 1| 7| 6| 7| 6|
DAY ON TEST | 5| 5| 3| 3| 3| 3| 5| 0| 2| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 5| 8| 3| 3| 3| 0|
| 6| 6| 3| 5| 4| 4| 5| 9| 9| 4| 2| 7| 2| 2| 3| 6| 3| 2| 3| 6| 9| 3| 7| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 2 |
Sinusoid, Dilatation | 4|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hemorrhage | 3 |
Hypothalamus, Compression | 3 3 |
Meninges, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | 1 |
Inflammation | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 1 |
Nephropathy | 1 1 1 3 2 2 1 2 2 1 3 1 3 1 1 1 2 1 1 1 1 1 1 2|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 4| 0| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 2| 5| 2| 2| 5| 5| 1| 3| 3| 2| 5| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3|
| 5| 9| 4| 9| 9| 5| 6| 3| 3| 4| 9| 5| 4| 3| 5| 3| 4| 3| 1| 4| 4| 3| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Developmental Malformation | X X X X |
Eosinophilic Focus | |
Fatty Change | 2 1 1 1 3 |
Fibrosis | 1 |
Inflammation, Chronic | 1 2 2 2 2 3|
Inflammation, Suppurative | |
Mixed Cell Focus | X |
Necrosis, Coagulative | 3 3 |
Necrosis | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 3 2 3 1 1 2 2 1 1 1 1 |
Hepatocyte, Degeneration, Granular | 1 1 2 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Inflammation, Chronic | 2 |
Fat, Mineralization | 2 |
Fat, Necrosis, Coagulative | 2 1 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | 3 |
Ulcer | 3 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 2 2 2 1 2|
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 4| 0| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 2| 5| 2| 2| 5| 5| 1| 3| 3| 2| 5| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3|
| 5| 9| 4| 9| 9| 5| 6| 3| 3| 4| 9| 5| 4| 3| 5| 3| 4| 3| 1| 4| 4| 3| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 X|
Pars Nervosa, Cyst Multilocular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2|
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Duct, Dilatation | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Corpus Luteum, Cyst | 3 |
Follicle, Cyst | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 1 3 3 |
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Hemorrhage, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 4| 0| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 6| 2| 5| 2| 2| 5| 5| 1| 3| 3| 2| 5| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3|
| 5| 9| 4| 9| 9| 5| 6| 3| 3| 4| 9| 5| 4| 3| 5| 3| 4| 3| 1| 4| 4| 3| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | |
Sinusoid, Dilatation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hemorrhage | |
Hypothalamus, Compression | 3 |
Meninges, Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 1 1 1 |
Inflammation | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | |
Nephropathy | 4 2 1 1 1 1 1 3 2 1 2 3 1 2 1 1 2 3 1 2 1|
Cortex, Cyst | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 5| 9| | |
| 4| 3| 4| 3| 2| 4| 4| 6| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Basophilic Focus | X X X X | 17 |
Developmental Malformation | X X X | 9 |
Eosinophilic Focus | | 1 |
Fatty Change | 1 | 12 1.6|
Fibrosis | | 1 1.0|
Inflammation, Chronic | 1 1 2 2 2 | 21 1.9|
Inflammation, Suppurative | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Coagulative | | 4 2.0|
Necrosis | | 1 1.0|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 | 30 1.3|
Hepatocyte, Degeneration, Granular | 1 1 1 | 11 1.4|
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Fat, Inflammation, Chronic | | 2 2.5|
Fat, Mineralization | | 1 2.0|
Fat, Necrosis, Coagulative | 3 | 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 48 |
Acinus, Atrophy | | 4 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | 4 | 6 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 5| 9| | |
| 4| 3| 4| 3| 2| 4| 4| 6| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Polyarteritis, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 3 2 2 2 2 | 22 2.0|
Fibrosis | | 2 2.5|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 48 |
Clear Cell Focus | 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + | 45 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 48 |
Pars Distalis, Cyst | X 3 | 7 3.0|
Pars Nervosa, Cyst Multilocular | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
C-Cell, Hyperplasia | 2 2 | 6 2.0|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 49 |
Inflammation, Suppurative | 3 | 7 3.6|
Duct, Dilatation | 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 50 |
Corpus Luteum, Cyst | | 1 3.0|
Follicle, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 52 |
Hydrometra | 4 4 | 8 2.9|
Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 5| 9| | |
| 4| 3| 4| 3| 2| 4| 4| 6| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 49 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Pancreatic, Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 48 |
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 49 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Pigmentation, Hemosiderin | | 1 2.0|
Sinusoid, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 50 |
Galactocele | X | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Cerebrum, Hemorrhage | | 1 3.0|
Hypothalamus, Compression | | 3 3.0|
Meninges, Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | | 1 2.0|
Foreign Body | | 4 1.0|
Inflammation | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 5| 9| | |
| 4| 3| 4| 3| 2| 4| 4| 6| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | | 1 1.0|
Nephropathy | 3 2 1 1 2 2 1 1 3 | 54 1.6|
Cortex, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 4| 7| 3| 4| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 3| 5| 3| 3| 5| 3| 7| 5| 3| 5| 7| 2| 3| 8| 5| 3| 3| 3| 9| 3| 9| 3|
| 6| 9| 3| 2| 1| 2| 2| 6| 2| 5| 5| 2| 6| 9| 9| 2| 6| 1| 2| 4| 4| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X |
Cytologic Alterations | 3 3 3 3 |
Developmental Malformation | X X X X |
Eosinophilic Focus | X |
Fatty Change | 3 2 2 2 |
Fibrosis | 3 3 2 2 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1|
Mineralization | 2 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 1 3 1 1 1 1 |
Bile Duct, Hyperplasia | 1 1 2 2 2 1 2 1 1 1 1|
Hepatocyte, Cytologic Alterations | |
Hepatocyte, Degeneration, Granular | 1 2 3 2 1 2 1 1 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + +|
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 1 1 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Ulcer | 3 3 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Ulcer | 3 2 3 |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 4| 7| 3| 4| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 3| 5| 3| 3| 5| 3| 7| 5| 3| 5| 7| 2| 3| 8| 5| 3| 3| 3| 9| 3| 9| 3|
| 6| 9| 3| 2| 1| 2| 2| 6| 2| 5| 5| 2| 6| 9| 9| 2| 6| 1| 2| 4| 4| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 1 2 2 2 2 2 2 1 2|
Fibrosis | |
Inflammation, Suppurative | |
Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + M + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hydrometra | 3 3 1 3 3 3 2 3|
Hyperplasia, Cystic | |
Epithelium, Cytoplasmic Alteration | |
__________________________________________________________________________|
Vagina | + + |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + A + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 4| 7| 3| 4| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 5| 2| 3| 3| 5| 3| 3| 5| 3| 7| 5| 3| 5| 7| 2| 3| 8| 5| 3| 3| 3| 9| 3| 9| 3|
| 6| 9| 3| 2| 1| 2| 2| 6| 2| 5| 5| 2| 6| 9| 9| 2| 6| 1| 2| 4| 4| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 3 2 3 2 4 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Anterior Chamber, Edema | |
Cornea, Edema | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Nephropathy | 1 2 2 3 3 2 2 1 3 1 2 1 3 2 2 3 3 1 2 3 3 1 3 2|
Cortex, Cyst | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 4| 5| 6| 4| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 4| 4| 6|
DAY ON TEST | 3| 3| 4| 2| 7| 5| 8| 6| 5| 3| 5| 3| 3| 3| 5| 9| 5| 3| 3| 5| 3| 3| 6| 5| 4|
| 4| 2| 3| 9| 9| 6| 0| 5| 5| 4| 6| 4| 3| 3| 8| 1| 6| 2| 3| 6| 2| 3| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X |
Cytologic Alterations | 2 3 2 2 |
Developmental Malformation | X X |
Eosinophilic Focus | |
Fatty Change | 1 2 3 1 2 3 2 4 2 2 2 2 2 |
Fibrosis | 1 2 2 2 |
Inflammation, Chronic | 1 1 1 1 1 |
Mineralization | |
Mixed Cell Focus | X |
Necrosis, Coagulative | 1 2 3 3 1 1|
Bile Duct, Hyperplasia | 1 2 3 1 2 1 1 1 1 |
Hepatocyte, Cytologic Alterations | |
Hepatocyte, Degeneration, Granular | 2 2 3 1 2 1 3 1 2 1 2 1 2 3 1 3 2 1 |
__________________________________________________________________________|
Mesentery | + M |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + A|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperkeratosis | |
Ulcer | 4 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 3 2 3 2 |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 4| 5| 6| 4| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 4| 4| 6|
DAY ON TEST | 3| 3| 4| 2| 7| 5| 8| 6| 5| 3| 5| 3| 3| 3| 5| 9| 5| 3| 3| 5| 3| 3| 6| 5| 4|
| 4| 2| 3| 9| 9| 6| 0| 5| 5| 4| 6| 4| 3| 3| 8| 1| 6| 2| 3| 6| 2| 3| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 2 2 1 2 2 |
Fibrosis | |
Inflammation, Suppurative | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | X 2 X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3|
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Follicle, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 |
Hyperplasia, Cystic | |
Epithelium, Cytoplasmic Alteration | |
__________________________________________________________________________|
Vagina | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 6| 4| 5| 6| 4| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 4| 4| 6|
DAY ON TEST | 3| 3| 4| 2| 7| 5| 8| 6| 5| 3| 5| 3| 3| 3| 5| 9| 5| 3| 3| 5| 3| 3| 6| 5| 4|
| 4| 2| 3| 9| 9| 6| 0| 5| 5| 4| 6| 4| 3| 3| 8| 1| 6| 2| 3| 6| 2| 3| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + I + + + + + M +|
Congestion | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | X |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 4 3|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Inflammation, Suppurative | 3 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Edema | 3 |
Cornea, Edema | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 2 3 3 4 1 1 3 2 2 4 3 3 1 1 3 3 2 3 2 1 2 1|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + A|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| 1| 2| 4| 9| 2| 5| 3| | |
| 4| 3| 2| 9| 9| 2| 3| 9| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + A + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Ulcer | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X | 21 |
Clear Cell Focus | X | 3 |
Cytologic Alterations | 1 | 9 2.4|
Developmental Malformation | | 6 |
Eosinophilic Focus | X | 2 |
Fatty Change | | 17 2.2|
Fibrosis | 2 1 1 | 12 1.8|
Inflammation, Chronic | 1 1 2 1 | 21 1.1|
Mineralization | | 1 2.0|
Mixed Cell Focus | X | 3 |
Necrosis, Coagulative | 2 3 1 | 15 1.7|
Bile Duct, Hyperplasia | 3 1 1 | 23 1.4|
Hepatocyte, Cytologic Alterations | 1 | 1 1.0|
Hepatocyte, Degeneration, Granular | 1 2 1 2 1 | 39 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Inflammation, Chronic | 3 | 2 3.0|
Fat, Necrosis, Coagulative | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + | 56 |
Acinus, Atrophy | | 4 2.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperkeratosis | | 1 3.0|
Ulcer | 4 | 9 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + | 57 |
Ulcer | | 7 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| 1| 2| 4| 9| 2| 5| 3| | |
| 4| 3| 2| 9| 9| 2| 3| 9| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 2 | 23 1.9|
Fibrosis | 2 | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Clear Cell Focus | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Cyst | | 6 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 1 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Inflammation, Suppurative | 4 | 4 3.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Follicle, Cyst | | 2 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hydrometra | 3 3 | 12 2.6|
Hyperplasia, Cystic | 2 | 1 2.0|
Epithelium, Cytoplasmic Alteration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + + | 4 |
Hyperkeratosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| 1| 2| 4| 9| 2| 5| 3| | |
| 4| 3| 2| 9| 9| 2| 3| 9| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + | 59 |
Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Mediastinal, Hyperplasia, Macrophage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Congestion | 4 | 1 4.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 56 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Galactocele | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture | | 1 |
Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Hypothalamus, Compression | | 2 3.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | | 1 3.0|
Inflammation, Suppurative | 2 2 1 2 | 15 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| 1| 2| 4| 9| 2| 5| 3| | |
| 4| 3| 2| 9| 9| 2| 3| 9| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Anterior Chamber, Edema | | 1 3.0|
Cornea, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Nephropathy | 1 2 3 2 3 1 3 2 1 3 | 59 2.2|
Cortex, Cyst | 2 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 0| 7| 7| 4| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 5| 0| 3| 2| 5| 2| 2| 6| 8| 2| 9| 0| 2| 2| 3| 5| 2| 3| 1| 2| 2| 5|
| 0| 9| 9| 5| 5| 0| 9| 6| 9| 9| 0| 6| 9| 4| 9| 9| 9| 0| 3| 9| 0| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X 2 X X |
Clear Cell Focus | 2 X 2 |
Developmental Malformation | X |
Eosinophilic Focus | X X X |
Fatty Change | 1 |
Hyperplasia | 3 |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Chronic | 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 2 2 1 1 1 2 1 2 3 2 2 2 1 2 1 2 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Coagulative | 4 2 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Acinar Cell, Hyperplasia | 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 1 2 2 3 2 2 2 2 2 3 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 0| 7| 7| 4| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 5| 0| 3| 2| 5| 2| 2| 6| 8| 2| 9| 0| 2| 2| 3| 5| 2| 3| 1| 2| 2| 5|
| 0| 9| 9| 5| 5| 0| 9| 6| 9| 9| 0| 6| 9| 4| 9| 9| 9| 0| 3| 9| 0| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Congestion | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Intermedia, Hemorrhage | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 3 3 3 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Mononuclear Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + I + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 0| 7| 7| 4| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 5| 0| 3| 2| 5| 2| 2| 6| 8| 2| 9| 0| 2| 2| 3| 5| 2| 3| 1| 2| 2| 5|
| 0| 9| 9| 5| 5| 0| 9| 6| 9| 9| 0| 6| 9| 4| 9| 9| 9| 0| 3| 9| 0| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | X |
Hypoplasia | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + M + + + + + + + + +|
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X X |
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Developmental | |
Malformation | |
Hypothalamus, Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Inflammation, Suppurative | 2 1 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 1 3 2 1 2 2 1 3 1 2 3 2 1 2 2 2 2 1 2 2 2 1 3 1|
Cortex, Cyst | 4 |
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 0| 7| 7| 4| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 5| 0| 3| 2| 5| 2| 2| 6| 8| 2| 9| 0| 2| 2| 3| 5| 2| 3| 1| 2| 2| 5|
| 0| 9| 9| 5| 5| 0| 9| 6| 9| 9| 0| 6| 9| 4| 9| 9| 9| 0| 3| 9| 0| 3| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 4| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 4| 4| 3| 7| 4|
DAY ON TEST | 3| 2| 0| 9| 2| 5| 7| 7| 5| 2| 2| 2| 3| 2| 2| 1| 2| 5| 2| 5| 5| 0| 3| 3| 7|
| 0| 3| 4| 9| 9| 5| 1| 3| 5| 9| 9| 9| 0| 0| 8| 1| 9| 3| 9| 5| 3| 8| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + M M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + M + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + M + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + M M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A M + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + M M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + M A M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Developmental Malformation | X |
Eosinophilic Focus | |
Fatty Change | 2 1 |
Hyperplasia | 1 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Mixed Cell Focus | X X |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 2 1 2 2 4 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Fat, Hemorrhage | |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis, Coagulative | 3 2 4 3 4 3 4|
__________________________________________________________________________|
Pancreas | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Acinar Cell, Hyperplasia | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Ulcer | 4 2 4 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + A + M + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 3 2 2 3 3 2 2 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 4| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 4| 4| 3| 7| 4|
DAY ON TEST | 3| 2| 0| 9| 2| 5| 7| 7| 5| 2| 2| 2| 3| 2| 2| 1| 2| 5| 2| 5| 5| 0| 3| 3| 7|
| 0| 3| 4| 9| 9| 5| 1| 3| 5| 9| 9| 9| 0| 0| 8| 1| 9| 3| 9| 5| 3| 8| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Congestion | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + + M + + + + + + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Intermedia, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + M M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + M M M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 4 4 |
__________________________________________________________________________|
Prostate | + M M M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 2 3 3|
__________________________________________________________________________|
Seminal Vesicle | + M M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + M M M + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Mononuclear Cell | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 4| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 4| 4| 3| 7| 4|
DAY ON TEST | 3| 2| 0| 9| 2| 5| 7| 7| 5| 2| 2| 2| 3| 2| 2| 1| 2| 5| 2| 5| 5| 0| 3| 3| 7|
| 0| 3| 4| 9| 9| 5| 1| 3| 5| 9| 9| 9| 0| 0| 8| 1| 9| 3| 9| 5| 3| 8| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | X |
Hypoplasia | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | 3 |
Inflammation, Chronic | 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + A A + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Developmental | |
Malformation | X |
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Inflammation, Suppurative | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 3 2 4 3 2 1 3 2 1 1 1 3 3 2 1 2 1 1 3 1 1 1 1 2 1|
Cortex, Cyst | |
Renal Tubule, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 4| 6| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 4| 4| 3| 7| 4|
DAY ON TEST | 3| 2| 0| 9| 2| 5| 7| 7| 5| 2| 2| 2| 3| 2| 2| 1| 2| 5| 2| 5| 5| 0| 3| 3| 7|
| 0| 3| 4| 9| 9| 5| 1| 3| 5| 9| 9| 9| 0| 0| 8| 1| 9| 3| 9| 5| 3| 8| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + M M M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 3| 7| 5| 6| 7| 7| 6| | |
DAY ON TEST | 5| 2| 2| 7| 2| 7| 0| 3| 2| 2| | |
| 5| 9| 9| 2| 9| 8| 1| 0| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + M A + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M A + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M A + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 56 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + M + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | X X X | 16 2.0|
Clear Cell Focus | | 5 2.0|
Developmental Malformation | | 2 |
Eosinophilic Focus | X X | 5 |
Fatty Change | 1 | 4 1.3|
Hyperplasia | | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 | 3 2.0|
Inflammation, Chronic | | 1 1.0|
Mixed Cell Focus | X | 4 |
Necrosis, Coagulative | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 1 2 1 2 2 2 1 | 47 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 21 |
Fat, Hemorrhage | 4 | 1 4.0|
Fat, Inflammation, Chronic | 3 | 2 3.0|
Fat, Necrosis, Coagulative | 3 3 | 15 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + | 57 |
Atrophy | | 4 2.3|
Acinar Cell, Hyperplasia | | 1 2.0|
Acinus, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperkeratosis | | 2 2.0|
Ulcer | 4 | 7 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 3| 7| 5| 6| 7| 7| 6| | |
DAY ON TEST | 5| 2| 2| 7| 2| 7| 0| 3| 2| 2| | |
| 5| 9| 9| 2| 9| 8| 1| 0| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 3 3 2 3 | 36 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Basophilic Focus | | 1 2.0|
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + + | 51 |
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | | 1 2.0|
Pars Intermedia, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + | 57 |
C-Cell, Hyperplasia | 2 | 6 2.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + M + + + + | 55 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M + + + + | 55 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 3 2 | 8 2.6|
Duct, Dilatation | | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + | 55 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 3 | 4 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + M + + + + | 55 |
__________________________________________________________________________|____________|
Testes | + + + + + M + + + + | 55 |
Interstitial Cell, Hyperplasia | 3 | 3 2.3|
Seminiferous Tubule, Atrophy | | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 3| 7| 5| 6| 7| 7| 6| | |
DAY ON TEST | 5| 2| 2| 7| 2| 7| 0| 3| 2| 2| | |
| 5| 9| 9| 2| 9| 8| 1| 0| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Hyperplasia, Mononuclear Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + | 53 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Congestion | | 2 3.0|
Developmental Malformation | | 2 |
Hypoplasia | | 1 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + | 54 |
Galactocele | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | | 3 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 57 |
Cerebellum, Developmental | | |
Malformation | | 1 |
Hypothalamus, Compression | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 3| 7| 5| 6| 7| 7| 6| | |
DAY ON TEST | 5| 2| 2| 7| 2| 7| 0| 3| 2| 2| | |
| 5| 9| 9| 2| 9| 8| 1| 0| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 3 | 5 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | 3 4 | 4 3.5|
Inflammation, Suppurative | 3 2 2 3 | 15 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Congestion | 2 | 1 2.0|
Nephropathy | 1 2 1 1 2 1 3 3 2 | 58 1.8|
Cortex, Cyst | | 1 4.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + | 55 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 6| 7| 6| 6| 4| 5| 6| 6| 6| 7| 5| 6| 6| 6| 6| 4| 6| 7| 7| 5| 6|
DAY ON TEST | 8| 7| 3| 5| 3| 2| 4| 2| 5| 7| 1| 1| 2| 2| 9| 2| 5| 6| 7| 5| 7| 2| 2| 0| 4|
| 2| 3| 0| 3| 9| 9| 5| 2| 3| 7| 1| 3| 5| 9| 3| 5| 2| 1| 5| 6| 1| 9| 9| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Suppurative | |
Periesophageal Tissue, Hemorrhage | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Developmental Malformation | |
Eosinophilic Focus | |
Fatty Change | 1 1 1 2 |
Fibrosis | 1 |
Hyperplasia | 3 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 2 1 2 1 3 2 1 1 |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 4 2 1 1 2 2 1 1 1 1 2 2 1|
Hepatocyte, Degeneration, Granular | 1 |
Periductular, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Inflammation, Chronic | 2|
Fat, Inflammation, Suppurative | 2 3 |
Fat, Necrosis, Coagulative | 3 3 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 4 1 2 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Acinus, Hyperplasia | |
Vein, Dilatation | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 3 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 6| 7| 6| 6| 4| 5| 6| 6| 6| 7| 5| 6| 6| 6| 6| 4| 6| 7| 7| 5| 6|
DAY ON TEST | 8| 7| 3| 5| 3| 2| 4| 2| 5| 7| 1| 1| 2| 2| 9| 2| 5| 6| 7| 5| 7| 2| 2| 0| 4|
| 2| 3| 0| 3| 9| 9| 5| 2| 3| 7| 1| 3| 5| 9| 3| 5| 2| 1| 5| 6| 1| 9| 9| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 4 3 3|
Inflammation, Suppurative | |
Ulcer | 4 4 4 2 3 3 3 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Mineralization | 2 |
Ulcer | 2 3 2 2|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
Mesenteric Artery, Arteriosclerosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + M + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
Cytoplasmic Alteration | 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + M + + + +|
Hyperplasia | 3 2 3 2 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 3 3 3 4 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 6| 7| 6| 6| 4| 5| 6| 6| 6| 7| 5| 6| 6| 6| 6| 4| 6| 7| 7| 5| 6|
DAY ON TEST | 8| 7| 3| 5| 3| 2| 4| 2| 5| 7| 1| 1| 2| 2| 9| 2| 5| 6| 7| 5| 7| 2| 2| 0| 4|
| 2| 3| 0| 3| 9| 9| 5| 2| 3| 7| 1| 3| 5| 9| 3| 5| 2| 1| 5| 6| 1| 9| 9| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 2 3 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + A + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hemorrhage | |
Mediastinal, Hemorrhage | 2 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + M + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 3 |
Infarct | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + M + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 4 |
Sebaceous Gland, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Proliferation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 6| 7| 4| 6| 7| 6| 6| 4| 5| 6| 6| 6| 7| 5| 6| 6| 6| 6| 4| 6| 7| 7| 5| 6|
DAY ON TEST | 8| 7| 3| 5| 3| 2| 4| 2| 5| 7| 1| 1| 2| 2| 9| 2| 5| 6| 7| 5| 7| 2| 2| 0| 4|
| 2| 3| 0| 3| 9| 9| 5| 2| 3| 7| 1| 3| 5| 9| 3| 5| 2| 1| 5| 6| 1| 9| 9| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
Hemorrhage | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + M + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Macrophage | 1 |
Inflammation, Suppurative | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Hemorrhage | |
Inflammation, Suppurative | 3 1 1 1 4 2 1 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 3 3 1 3 4 3 4 1 3 2 3 3 3 4 3 3 2 4 1 2 3 3 1 4|
Cortex, Cyst | X|
Renal Tubule, Hyperplasia | 4 |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 3| 4| 6| 3| 4| 6| 4| 4| 6| 7| 6| 6| 6| 6| 4| 6| 4| 6| 5| 0| 6| 6| 5| 7| 7|
DAY ON TEST | 5| 5| 9| 4| 5| 0| 5| 5| 3| 1| 8| 7| 5| 6| 9| 1| 5| 6| 1| 9| 9| 3| 6| 3| 2|
| 2| 5| 4| 3| 5| 0| 5| 3| 6| 9| 0| 5| 7| 6| 2| 5| 3| 0| 8| 0| 2| 1| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Periesophageal Tissue, Hemorrhage | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Developmental Malformation | X|
Eosinophilic Focus | X |
Fatty Change | 1 3 2 1 1 1 2 1 |
Fibrosis | 2 |
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 4 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 1 2 1 |
Bile Duct, Hyperplasia | 2 2 2 2 1 1 2 1 2 3 2 1 1 2 1 2 1 2 2 1 3|
Hepatocyte, Degeneration, Granular | 1 1 1 2 |
Periductular, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Inflammation, Chronic | |
Fat, Inflammation, Suppurative | 4 4 |
Fat, Necrosis, Coagulative | 3 3 3|
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Acinus, Hyperplasia | 3 |
Vein, Dilatation | 3 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 3| 4| 6| 3| 4| 6| 4| 4| 6| 7| 6| 6| 6| 6| 4| 6| 4| 6| 5| 0| 6| 6| 5| 7| 7|
DAY ON TEST | 5| 5| 9| 4| 5| 0| 5| 5| 3| 1| 8| 7| 5| 6| 9| 1| 5| 6| 1| 9| 9| 3| 6| 3| 2|
| 2| 5| 4| 3| 5| 0| 5| 3| 6| 9| 0| 5| 7| 6| 2| 5| 3| 0| 8| 0| 2| 1| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 4 |
Ulcer | 4 4 3 4 4 3 3 4 4 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 |
Mineralization | 2 3 |
Ulcer | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Aorta, Mineralization | 3 |
Mesenteric Artery, Arteriosclerosis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 3 2 2 3 2 2 1 4 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cytoplasmic Alteration | |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 3 2 2 3 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + A + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X 3 |
Pars Distalis, Hypertrophy | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 3| 4| 6| 3| 4| 6| 4| 4| 6| 7| 6| 6| 6| 6| 4| 6| 4| 6| 5| 0| 6| 6| 5| 7| 7|
DAY ON TEST | 5| 5| 9| 4| 5| 0| 5| 5| 3| 1| 8| 7| 5| 6| 9| 1| 5| 6| 1| 9| 9| 3| 6| 3| 2|
| 2| 5| 4| 3| 5| 0| 5| 3| 6| 9| 0| 5| 7| 6| 2| 5| 3| 0| 8| 0| 2| 1| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hemorrhage | |
Mediastinal, Hemorrhage | 2 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 4 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | |
Infarct | 3 4 |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + M + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hemorrhage | 1 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Sebaceous Gland, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Proliferation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 3| 4| 6| 3| 4| 6| 4| 4| 6| 7| 6| 6| 6| 6| 4| 6| 4| 6| 5| 0| 6| 6| 5| 7| 7|
DAY ON TEST | 5| 5| 9| 4| 5| 0| 5| 5| 3| 1| 8| 7| 5| 6| 9| 1| 5| 6| 1| 9| 9| 3| 6| 3| 2|
| 2| 5| 4| 3| 5| 0| 5| 3| 6| 9| 0| 5| 7| 6| 2| 5| 3| 0| 8| 0| 2| 1| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
Hemorrhage | 4 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Macrophage | |
Inflammation, Suppurative | 2 |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Hemorrhage | 2 |
Inflammation, Suppurative | 1 1 2 1 2 1 3 1 2|
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 4 1 2 2 3 2 4 4 3 3 3 2 4 2 4 4 4 4 4 4 3|
Cortex, Cyst | 3 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 6| 6| 5| 3| 4| | |
DAY ON TEST | 0| 2| 9| 2| 5| 7| 6| 8| 7| 5| | |
| 0| 9| 8| 9| 6| 1| 3| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 49 |
Inflammation, Suppurative | | 1 4.0|
Periesophageal Tissue, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + | 48 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + | 48 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 5 |
Developmental Malformation | | 1 |
Eosinophilic Focus | | 1 |
Fatty Change | 2 2 | 14 1.5|
Fibrosis | 1 | 3 1.3|
Hyperplasia | | 2 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 3 3.7|
Mixed Cell Focus | | 1 |
Necrosis, Coagulative | | 13 1.5|
Bile Duct, Hyperplasia | 4 2 2 2 2 1 2 1 2 | 49 1.8|
Hepatocyte, Degeneration, Granular | 2 2 1 | 8 1.4|
Periductular, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 12 |
Fat, Inflammation, Chronic | | 1 2.0|
Fat, Inflammation, Suppurative | | 4 3.3|
Fat, Necrosis, Coagulative | | 8 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 49 |
Atrophy | 2 2 | 7 2.1|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Acinus, Hyperplasia | | 1 3.0|
Vein, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 6| 6| 5| 3| 4| | |
DAY ON TEST | 0| 2| 9| 2| 5| 7| 6| 8| 7| 5| | |
| 0| 9| 8| 9| 6| 1| 3| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 49 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | A + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 51 |
Hyperkeratosis | | 3 2.7|
Inflammation, Chronic | | 3 3.3|
Inflammation, Suppurative | | 3 4.0|
Ulcer | 4 4 4 | 24 3.6|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + | 48 |
Inflammation, Chronic | | 2 2.5|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 2 | 4 2.3|
Ulcer | 4 | 5 2.6|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 4 |
Aorta, Mineralization | | 1 3.0|
Mesenteric Artery, Arteriosclerosis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 49 |
Cardiomyopathy | 2 2 2 3 3 2 2 | 34 2.1|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Clear Cell Focus | | 1 2.0|
Cytoplasmic Alteration | | 1 2.0|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
Basophilic Focus | | 1 2.0|
Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 47 |
Hyperplasia | 3 3 3 2 | 20 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 48 |
Pars Distalis, Cyst | | 4 3.0|
Pars Distalis, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 6| 6| 5| 3| 4| | |
DAY ON TEST | 0| 2| 9| 2| 5| 7| 6| 8| 7| 5| | |
| 0| 9| 8| 9| 6| 1| 3| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 49 |
Inflammation, Chronic | 3 | 2 3.5|
Inflammation, Suppurative | | 6 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
Hyperplasia | | 2 2.0|
Inflammation, Suppurative | 4 | 7 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Interstitial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Lumbar, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hemorrhage | | 2 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 47 |
Hyperplasia, Lymphoid | | 2 3.0|
Hyperplasia, Plasma Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 50 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Congestion | | 1 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infarct | | 2 3.5|
Inflammation, Suppurative | | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 48 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 6| 6| 5| 3| 4| | |
DAY ON TEST | 0| 2| 9| 2| 5| 7| 6| 8| 7| 5| | |
| 0| 9| 8| 9| 6| 1| 3| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 4.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | 4 | 3 3.7|
Inflammation, Suppurative | | 1 4.0|
Sebaceous Gland, Inflammation, | | |
Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Cranium, Proliferation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 49 |
Hemorrhage | | 1 2.0|
Hyperplasia, Macrophage | 2 | 2 1.5|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Fungus | | 2 3.0|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | 1 1 1 | 20 1.6|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 6| 6| 5| 3| 4| | |
DAY ON TEST | 0| 2| 9| 2| 5| 7| 6| 8| 7| 5| | |
| 0| 9| 8| 9| 6| 1| 3| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 2 3 3 3 1 4 4 4 2 3 | 58 2.8|
Cortex, Cyst | 3 | 3 3.0|
Renal Tubule, Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 6| 4| 5| 5| 5| 6| 6| 4| 5| 6| 6| 0| 6| 5| 4| 6| 6| 5| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 8| 2| 7| 9| 3| 4| 3| 2| 2| 9| 2| 2| 6| 0| 8| 5| 6| 7| 7| 2| 3| 9| 6| 5| 9|
| 0| 5| 3| 6| 9| 6| 1| 2| 8| 4| 2| 8| 3| 2| 8| 5| 6| 8| 5| 9| 1| 6| 9| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + A + A + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A A + A + + + + + + + M A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + A A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M A + + + + + + + + + + A M + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + A + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + A + M + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + A + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cytologic Alterations | 2 2 2 1 1 1 2 3 4 2 1 4 2 1 |
Developmental Malformation | |
Fatty Change | 3 1 1 1 2 2 1 |
Fibrosis | 1 2 2 3 1 2 3 2 2 1 2 2 1 1 1 1 2 1 1|
Inflammation, Suppurative | |
Mixed Cell Focus | |
Necrosis, Coagulative | 2 1 1 1 1 3 2 1 1 1 1 4 2 4 2 1 1 |
Bile Duct, Hyperplasia | 2 2 3 3 2 2 3 2 3 2 2 2 2 2 3 3 2 2 2 2|
Hepatocyte, Degeneration, Granular | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Ectopic Tissue | |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Coagulative | 3 4 2 2 1 3 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + +|
Atrophy | 2 |
Fibrosis | 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + A + + + +|
Necrosis, Caseous | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 |
Ulcer | 3 3 4 4 4 3 4 3 4 3 4 4 4 3 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 2 |
Ulcer | 2 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 6| 4| 5| 5| 5| 6| 6| 4| 5| 6| 6| 0| 6| 5| 4| 6| 6| 5| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 8| 2| 7| 9| 3| 4| 3| 2| 2| 9| 2| 2| 6| 0| 8| 5| 6| 7| 7| 2| 3| 9| 6| 5| 9|
| 0| 5| 3| 6| 9| 6| 1| 2| 8| 4| 2| 8| 3| 2| 8| 5| 6| 8| 5| 9| 1| 6| 9| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Polyarteritis | 4 4 |
Mesenteric Artery, Thrombosis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 3 2 2 3 3 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + +|
Clear Cell Focus | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + A + + + +|
Hyperplasia | 2 3 3 3 3 3 2 3 3 2 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + A + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + + M + + + + + + + + A M + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + A + + + +|
Edema | |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Testes | + + + + + M + + + M + + + + + + + + + A M + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + A + + + +|
Lumbar, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 6| 4| 5| 5| 5| 6| 6| 4| 5| 6| 6| 0| 6| 5| 4| 6| 6| 5| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 8| 2| 7| 9| 3| 4| 3| 2| 2| 9| 2| 2| 6| 0| 8| 5| 6| 7| 7| 2| 3| 9| 6| 5| 9|
| 0| 5| 3| 6| 9| 6| 1| 2| 8| 4| 2| 8| 3| 2| 8| 5| 6| 8| 5| 9| 1| 6| 9| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + +|
Fibrosis | |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
Necrosis, Coagulative | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + A + + + +|
Ectopic Tissue | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + M + + + + + + + + M + + + + +|
Galactocele | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | |
Degeneration | |
Hyperkeratosis | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + A + + + +|
Atelectasis | |
Edema | 1 |
Inflammation, Suppurative | 2|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 4 3|
Inflammation, Suppurative | 3 2 3 1 4 2 1 3 3 3 1 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 6| 4| 5| 5| 5| 6| 6| 4| 5| 6| 6| 0| 6| 5| 4| 6| 6| 5| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 8| 2| 7| 9| 3| 4| 3| 2| 2| 9| 2| 2| 6| 0| 8| 5| 6| 7| 7| 2| 3| 9| 6| 5| 9|
| 0| 5| 3| 6| 9| 6| 1| 2| 8| 4| 2| 8| 3| 2| 8| 5| 6| 8| 5| 9| 1| 6| 9| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | |
Pigmentation | 2 |
Cornea, Edema | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 3 4 3 4 4 4 4 2 4 4 4 4 4 2 4 4 4 1 4 4 4 2 4|
Cortex, Cyst | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 4| 6| 4| 4| 5| 6| 6| 4| 6| 5| 5| 4| 6| 5| 4| 6| 5| 5| 4| 5| 6|
DAY ON TEST | 5| 5| 4| 5| 5| 2| 5| 0| 1| 0| 4| 5| 9| 4| 0| 5| 4| 2| 5| 1| 4| 0| 5| 3| 1|
| 3| 6| 3| 5| 5| 2| 3| 8| 7| 1| 5| 5| 4| 5| 6| 6| 3| 5| 3| 5| 8| 6| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + I + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
Ulcer | 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cytologic Alterations | 2 1 1 2 1 2 3 2 1|
Developmental Malformation | |
Fatty Change | 1 2 1 1 1 1 |
Fibrosis | 2 2 1 1 2 2 1 1 2 2 2 1 2 1|
Inflammation, Suppurative | 3 |
Mixed Cell Focus | |
Necrosis, Coagulative | 2 2 2 1 4 1 2 2 2 2 3 1 1 1|
Bile Duct, Hyperplasia | 1 2 2 1 2 2 2 3 3 2 2 3 1 2 2 2 1 1 4 2 1 1 2 3|
Hepatocyte, Degeneration, Granular | 3 1 2 1 1 3 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Ectopic Tissue | |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Coagulative | 2 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Necrosis, Caseous | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Inflammation, Chronic | 2 3 4|
Inflammation, Suppurative | |
Ulcer | 4 3 3 4 4 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 2 3 |
Ulcer | 2 2 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 4| 6| 4| 4| 5| 6| 6| 4| 6| 5| 5| 4| 6| 5| 4| 6| 5| 5| 4| 5| 6|
DAY ON TEST | 5| 5| 4| 5| 5| 2| 5| 0| 1| 0| 4| 5| 9| 4| 0| 5| 4| 2| 5| 1| 4| 0| 5| 3| 1|
| 3| 6| 3| 5| 5| 2| 3| 8| 7| 1| 5| 5| 4| 5| 6| 6| 3| 5| 3| 5| 8| 6| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Polyarteritis | |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 2 3 2 2 3|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 2 3 3 2 3 2 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 4 4 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | |
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + M + + + + + +|
Lumbar, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 4| 6| 4| 4| 5| 6| 6| 4| 6| 5| 5| 4| 6| 5| 4| 6| 5| 5| 4| 5| 6|
DAY ON TEST | 5| 5| 4| 5| 5| 2| 5| 0| 1| 0| 4| 5| 9| 4| 0| 5| 4| 2| 5| 1| 4| 0| 5| 3| 1|
| 3| 6| 3| 5| 5| 2| 3| 8| 7| 1| 5| 5| 4| 5| 6| 6| 3| 5| 3| 5| 8| 6| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | 3 |
Necrosis, Coagulative | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M +|
Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + M + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Cyst Epithelial Inclusion | 4 3 |
Degeneration | 2 |
Hyperkeratosis | 2 |
Inflammation, Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 |
Edema | |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Inflammation, Suppurative | 1 2 2 3 2 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 4| 6| 4| 4| 5| 6| 6| 4| 6| 5| 5| 4| 6| 5| 4| 6| 5| 5| 4| 5| 6|
DAY ON TEST | 5| 5| 4| 5| 5| 2| 5| 0| 1| 0| 4| 5| 9| 4| 0| 5| 4| 2| 5| 1| 4| 0| 5| 3| 1|
| 3| 6| 3| 5| 5| 2| 3| 8| 7| 1| 5| 5| 4| 5| 6| 6| 3| 5| 3| 5| 8| 6| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 2 |
Pigmentation | |
Cornea, Edema | |
__________________________________________________________________________|
Zymbal's Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 4 3 4 3 3 2 2 4 4 4 2 4 4 4 2 4 4 2 4 3 4 3 4 4|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 4| 5| 7| 5| 7| 6| | |
DAY ON TEST | 7| 5| 3| 3| 9| 1| 2| 8| 3| 0| | |
| 9| 7| 1| 0| 8| 2| 9| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + M + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + M + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + M + + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + | 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + M + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 48 |
Ulcer | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + M + + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X | 2 |
Cytologic Alterations | 2 2 1 2 1 | 28 1.8|
Developmental Malformation | X | 1 |
Fatty Change | 2 2 | 15 1.5|
Fibrosis | 1 1 3 1 2 1 2 1 | 41 1.6|
Inflammation, Suppurative | 4 3 | 3 3.3|
Mixed Cell Focus | X | 1 |
Necrosis, Coagulative | 1 1 2 1 1 3 2 | 38 1.7|
Bile Duct, Hyperplasia | 2 2 3 2 2 1 2 3 3 2 | 54 2.1|
Hepatocyte, Degeneration, Granular | | 8 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + | 18 |
Ectopic Tissue | X | 1 |
Fat, Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis, Coagulative | 3 2 3 | 16 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Atrophy | 3 | 2 2.5|
Fibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pharynx | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
Necrosis, Caseous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 51 |
Hyperkeratosis | | 4 2.8|
Inflammation, Chronic | 3 | 5 3.0|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 4 4 4 4 3 4 4 4 | 35 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 49 |
Inflammation, Chronic | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 4| 5| 7| 5| 7| 6| | |
DAY ON TEST | 7| 5| 3| 3| 9| 1| 2| 8| 3| 0| | |
| 9| 7| 1| 0| 8| 2| 9| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 2 3 | 5 2.4|
Ulcer | | 8 2.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Mesenteric Artery, Polyarteritis | | 2 4.0|
Mesenteric Artery, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 51 |
Cardiomyopathy | 2 3 2 3 2 2 2 | 25 2.3|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Clear Cell Focus | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 49 |
Hyperplasia | 3 2 3 3 2 2 3 | 31 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + M + + | 46 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 3 4.0|
Duct, Dilatation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Edema | 3 | 1 3.0|
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 3 | 6 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + M + + | 54 |
Interstitial Cell, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 4| 5| 7| 5| 7| 6| | |
DAY ON TEST | 7| 5| 3| 3| 9| 1| 2| 8| 3| 0| | |
| 9| 7| 1| 0| 8| 2| 9| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Lumbar, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 51 |
Fibrosis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Suppurative | 3 | 2 3.0|
Necrosis, Coagulative | 3 | 1 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 48 |
Ectopic Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + | 44 |
Galactocele | | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 51 |
Acanthosis | | 1 3.0|
Cyst Epithelial Inclusion | | 2 3.5|
Degeneration | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 51 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 4| 5| 7| 5| 7| 6| | |
DAY ON TEST | 7| 5| 3| 3| 9| 1| 2| 8| 3| 0| | |
| 9| 7| 1| 0| 8| 2| 9| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 51 |
Atelectasis | | 1 2.0|
Edema | | 1 1.0|
Inflammation, Suppurative | 4 | 2 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 52 |
Fungus | | 4 3.8|
Inflammation, Suppurative | 1 1 1 1 3 | 28 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 1 2.0|
Pigmentation | | 1 2.0|
Cornea, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 4 4 4 4 4 4 4 3 3 4 | 59 3.5|
Cortex, Cyst | 2 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 0| 5| 5| 6| 6| 4| 4| 6| 6| 4| 4| 5| 6| 6| 4| 4| 5| 4| 5| 4| 5| 4| 5| 6|
DAY ON TEST | 8| 1| 1| 6| 9| 3| 5| 2| 3| 1| 5| 9| 9| 0| 3| 5| 2| 8| 5| 6| 5| 0| 8| 2| 1|
| 9| 9| 0| 3| 8| 6| 3| 6| 0| 8| 3| 6| 5| 1| 1| 5| 0| 0| 6| 0| 6| 3| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Cyst | |
Cytologic Alterations | 4 4 2 3 3 1 4 4 1|
Developmental Malformation | X |
Eosinophilic Focus | X 3 |
Fatty Change | 2 |
Fibrosis | 2 3 2 1 1 3 2 2 2 2 3 2 1 2 1 2|
Hemorrhage | 3 3 |
Hyperplasia | 2 |
Inflammation, Suppurative | |
Mineralization | 2 |
Necrosis, Coagulative | 1 4 2 2 3 4 1 3 2 4 2 2 3 4 2 1 4|
Bile Duct, Hyperplasia | 2 3 3 1 2 1 2 3 2 2 2 3 2 2 1 2 4 2 3 2 1 1 2|
Hepatocyte, Degeneration, Granular | 1 1 |
__________________________________________________________________________|
Mesentery | + + M |
Fat, Inflammation, Chronic | |
Fat, Inflammation, Suppurative | |
Fat, Necrosis, Coagulative | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 3 |
Mineralization | 2 |
Ulcer | 4 4 3 4 4 4 3 3 4 3 4 4 4 3 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 0| 5| 5| 6| 6| 4| 4| 6| 6| 4| 4| 5| 6| 6| 4| 4| 5| 4| 5| 4| 5| 4| 5| 6|
DAY ON TEST | 8| 1| 1| 6| 9| 3| 5| 2| 3| 1| 5| 9| 9| 0| 3| 5| 2| 8| 5| 6| 5| 0| 8| 2| 1|
| 9| 9| 0| 3| 8| 6| 3| 6| 0| 8| 3| 6| 5| 1| 1| 5| 0| 0| 6| 0| 6| 3| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 3 3|
Ulcer | 3 4 2 2 |
__________________________________________________________________________|
Tongue | |
Necrosis, Zenkers | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | +|
Aorta, Mineralization | 3|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 3 2 2 2 2 2 2 3|
Atrioventricular Valve, Inflammation,| |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 3 3 3 2 3 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | M |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + M + + + +|
Inflammation, Suppurative | |
Duct, Dilatation | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 0| 5| 5| 6| 6| 4| 4| 6| 6| 4| 4| 5| 6| 6| 4| 4| 5| 4| 5| 4| 5| 4| 5| 6|
DAY ON TEST | 8| 1| 1| 6| 9| 3| 5| 2| 3| 1| 5| 9| 9| 0| 3| 5| 2| 8| 5| 6| 5| 0| 8| 2| 1|
| 9| 9| 0| 3| 8| 6| 3| 6| 0| 8| 3| 6| 5| 1| 1| 5| 0| 0| 6| 0| 6| 3| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hemorrhage | |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 3 3 3 |
Infiltration Cellular, Histiocyte | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Congestion | 4 |
Pigmentation, Hemosiderin | |
Thrombosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + + + + M + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + A + + + +|
Meninges, Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Hyperplasia, Macrophage | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Hemorrhage | |
Inflammation, Suppurative | 2 2 1 1 1 1 2 2 1 2 1 2 2 1 2 1 3 1|
Olfactory Epithelium, Degeneration | 2 |
Respiratory Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 5| 0| 5| 5| 6| 6| 4| 4| 6| 6| 4| 4| 5| 6| 6| 4| 4| 5| 4| 5| 4| 5| 4| 5| 6|
DAY ON TEST | 8| 1| 1| 6| 9| 3| 5| 2| 3| 1| 5| 9| 9| 0| 3| 5| 2| 8| 5| 6| 5| 0| 8| 2| 1|
| 9| 9| 0| 3| 8| 6| 3| 6| 0| 8| 3| 6| 5| 1| 1| 5| 0| 0| 6| 0| 6| 3| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 1 4 4 4 4 2 3 4 3 2 4 4 3 4 3 2 4 2 4 3 4 4 4 4|
Cortex, Cyst | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 3| 5| 5| 6| 5| 5| 5| 5| 5| 4| 4| 6| 5| 3| 4| 6| 4| 4| 5| 4| 5| 6| 5| 6|
DAY ON TEST | 9| 8| 1| 3| 0| 5| 7| 3| 1| 5| 5| 5| 5| 6| 0| 5| 6| 7| 9| 1| 5| 8| 1| 1| 1|
| 6| 0| 8| 4| 7| 2| 2| 3| 1| 1| 3| 5| 4| 7| 7| 3| 0| 7| 2| 2| 5| 0| 8| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + A +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Clear Cell Focus | 3 |
Cyst | 3 |
Cytologic Alterations | 2 1 2 4 3 1 1 3 1 2 3 2 2 1 1|
Developmental Malformation | |
Eosinophilic Focus | X|
Fatty Change | 1 2 4|
Fibrosis | 3 1 1 1 1 2 3 3 1 2 3 3 1 1 1 1 2 3|
Hemorrhage | 3 |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 2 |
Mineralization | |
Necrosis, Coagulative | 3 2 1 3 1 3 2 2 3 4 1 1 1 3 3 1|
Bile Duct, Hyperplasia | 1 1 3 2 1 2 2 2 4 2 2 2 2 1 1 3 1 2 2 2 2 2 3|
Hepatocyte, Degeneration, Granular | 1 3 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic | 4 |
Fat, Inflammation, Suppurative | 3 2 |
Fat, Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | |
Mineralization | |
Ulcer | 3 4 4 4 4 3 3 4 3 4 4 4 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 3| 5| 5| 6| 5| 5| 5| 5| 5| 4| 4| 6| 5| 3| 4| 6| 4| 4| 5| 4| 5| 6| 5| 6|
DAY ON TEST | 9| 8| 1| 3| 0| 5| 7| 3| 1| 5| 5| 5| 5| 6| 0| 5| 6| 7| 9| 1| 5| 8| 1| 1| 1|
| 6| 0| 8| 4| 7| 2| 2| 3| 1| 1| 3| 5| 4| 7| 7| 3| 0| 7| 2| 2| 5| 0| 8| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 |
Ulcer | 2 2 |
__________________________________________________________________________|
Tongue | |
Necrosis, Zenkers | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 3 4 |
Atrioventricular Valve, Inflammation,| |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M M + + + + + + + + M +|
Hyperplasia | 3 2 3 3 3 3 2 3 3 3 3 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + M + + +|
Inflammation, Suppurative | 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 3| 5| 5| 6| 5| 5| 5| 5| 5| 4| 4| 6| 5| 3| 4| 6| 4| 4| 5| 4| 5| 6| 5| 6|
DAY ON TEST | 9| 8| 1| 3| 0| 5| 7| 3| 1| 5| 5| 5| 5| 6| 0| 5| 6| 7| 9| 1| 5| 8| 1| 1| 1|
| 6| 0| 8| 4| 7| 2| 2| 3| 1| 1| 3| 5| 4| 7| 7| 3| 0| 7| 2| 2| 5| 0| 8| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + M +|
Lumbar, Hemorrhage | 2|
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + M +|
Edema | 4 |
Hyperplasia, Lymphoid | 4 3 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2|
Congestion | |
Pigmentation, Hemosiderin | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Hemorrhage | 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hyperplasia, Macrophage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Hemorrhage | 3 |
Inflammation, Suppurative | 3 1 1 3 2 1 2 2 2 3 2 2 3 2 3 2 1 1 4 2|
Olfactory Epithelium, Degeneration | |
Respiratory Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
_____________________________________________________________________________________________________________________
| 4| 3| 5| 5| 6| 5| 5| 5| 5| 5| 4| 4| 6| 5| 3| 4| 6| 4| 4| 5| 4| 5| 6| 5| 6|
DAY ON TEST | 9| 8| 1| 3| 0| 5| 7| 3| 1| 5| 5| 5| 5| 6| 0| 5| 6| 7| 9| 1| 5| 8| 1| 1| 1|
| 6| 0| 8| 4| 7| 2| 2| 3| 1| 1| 3| 5| 4| 7| 7| 3| 0| 7| 2| 2| 5| 0| 8| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 2 4 4 4 4 4 3 4 4 3 2 4 4 1 3 4 4 4 2 3 4 3 4 4|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 5| 6| 4| 6| 6| 4| | |
DAY ON TEST | 1| 1| 4| 5| 6| 5| 5| 3| 4| 5| | |
| 8| 1| 3| 2| 6| 0| 5| 8| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + A A + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A A + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A A + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + + A A + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A A + + + + + | 56 |
Ulcer | | 3 3.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A A + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A A + + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 4 |
Clear Cell Focus | | 1 3.0|
Cyst | | 1 3.0|
Cytologic Alterations | 4 3 3 2 3 | 29 2.4|
Developmental Malformation | X X X | 4 |
Eosinophilic Focus | | 3 3.0|
Fatty Change | 1 1 | 6 1.8|
Fibrosis | 3 2 2 1 1 3 3 1 | 42 1.9|
Hemorrhage | | 3 3.0|
Hyperplasia | | 2 2.5|
Inflammation, Suppurative | | 2 2.5|
Mineralization | 3 | 2 2.5|
Necrosis, Coagulative | 1 1 3 3 4 1 2 2 | 41 2.3|
Bile Duct, Hyperplasia | 2 2 2 3 2 1 2 2 2 2 | 56 2.0|
Hepatocyte, Degeneration, Granular | 1 | 6 1.3|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Inflammation, Chronic | | 1 4.0|
Fat, Inflammation, Suppurative | | 2 2.5|
Fat, Necrosis, Coagulative | | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 | 4 2.3|
Inflammation, Suppurative | 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 5| 6| 4| 6| 6| 4| | |
DAY ON TEST | 1| 1| 4| 5| 6| 5| 5| 3| 4| 5| | |
| 8| 1| 3| 2| 6| 0| 5| 8| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
Ulcer | 4 3 3 4 3 3 | 34 3.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 2 4 | 5 2.8|
Ulcer | 2 | 7 2.4|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Necrosis, Zenkers | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 3 3 2 2 1 2 | 23 2.3|
Atrioventricular Valve, Inflammation,| | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Clear Cell Focus | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Hyperplasia | 3 3 3 2 3 | 29 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Cyst | | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 56 |
Inflammation, Suppurative | 4 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 5| 6| 4| 6| 6| 4| | |
DAY ON TEST | 1| 1| 4| 5| 6| 5| 5| 3| 4| 5| | |
| 8| 1| 3| 2| 6| 0| 5| 8| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Dilatation | | 3 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 5 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 58 |
Lumbar, Hemorrhage | 3 3 | 3 2.7|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Edema | | 1 4.0|
Hyperplasia, Lymphoid | | 5 3.2|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 2.0|
Congestion | | 1 4.0|
Pigmentation, Hemosiderin | 2 | 2 2.5|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + | 56 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 5| 6| 4| 6| 6| 4| | |
DAY ON TEST | 1| 1| 4| 5| 6| 5| 5| 3| 4| 5| | |
| 8| 1| 3| 2| 6| 0| 5| 8| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Meninges, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Foreign Body | | 1 1.0|
Hyperplasia, Macrophage | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 4 | 3 3.7|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 2 3 3 2 3 3 | 44 2.0|
Olfactory Epithelium, Degeneration | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 4 4 4 3 4 4 2 4 4 3 | 60 3.4|
Cortex, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | |
| 5| 4| 4| 4| 6| 4| 4| 0| 5| 4| 5| 5| 4| 4| 5| 4| 4| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | A + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A M + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Clear Cell Focus | X | 1 |
Fatty Change | 1 1 2 1 | 4 1.3|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 2 2 2 2 2 3 1 1 2 1 2 | 11 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Pars Distalis, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | |
| 5| 4| 4| 4| 6| 4| 4| 0| 5| 4| 5| 5| 4| 4| 5| 4| 4| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 | 9 1.1|
Seminiferous Tubule, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + | 2 |
__________________________________________________________________________|____________|
Skin | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 4 4 4 | 3 4.0|
Inflammation, Granulomatous | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Nose | A + + | 2 |
Congestion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + | 3 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | |
| 5| 4| 4| 4| 6| 4| 4| 0| 5| 4| 5| 5| 4| 4| 5| 4| 4| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + | 19 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 17 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| | |
| 5| 5| 4| 5| 4| 4| 5| 0| 4| 4| 4| 5| 3| 5| 5| 5| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
100MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Clear Cell Focus | X X | 2 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis, Coagulative | 2 2 1 2 1 2 1 1 2 2 3 | 11 1.7|
Necrosis, Multifocal | 1 1 2 2 2 1 | 6 1.5|
Bile Duct, Hyperplasia | 1 1 2 2 1 2 1 2 1 1 1 2 2 2 2 2 2 | 17 1.6|
Hepatocyte, Cytomegaly | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 18 1.1|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Coagulative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 2 1 2 1 1 1 1 1 2 | 9 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| | |
| 5| 5| 4| 5| 4| 4| 5| 0| 4| 4| 4| 5| 3| 5| 5| 5| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
100MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 2 1 1 1 | 14 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 3 3 | 2 3.0|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 2 |
Nasolacrimal Duct, Inflammation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| | |
| 5| 5| 4| 5| 4| 4| 5| 0| 4| 4| 4| 5| 3| 5| 5| 5| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
100MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 2 2 2 2 2 2 3 3 2 2 3 1 3 2 3 2 2 3 2 | 19 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Calculus Gross Observation | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2| | |
| 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
39 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + A + + + + + + A + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + A + + + + + + A + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + A + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + M + + + M + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + A + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + A + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + A + + + + + + A + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + M + + + + + + A + + + | 17 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | X X | 2 |
Developmental Malformation | X X | 2 |
Fatty Change | 3 2 | 2 2.5|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Necrosis, Coagulative | 1 3 | 2 2.0|
Bile Duct, Hyperplasia | 2 2 2 1 2 2 1 4 1 2 1 1 3 1 3 3 1 | 17 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 7 |
Fat, Inflammation, Chronic | 4 3 | 2 3.5|
Fat, Necrosis, Coagulative | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + | 19 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + A + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + | 19 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 3 3 | 2 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 2 3 2 | 3 2.3|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 4 4 3 | 3 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + | 18 |
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2| | |
| 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
39 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Mineralization | 4 | 1 4.0|
Mesenteric Artery, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 2 2 2 3 2 2 2 1 4 2 2 | 11 2.2|
Fibrosis | 3 | 1 3.0|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + | 19 |
Hyperplasia | 3 2 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Pars Distalis, Congestion | 2 | 1 2.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Follicular Cell, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + | 19 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 5| 7| 6| 3| 6| 6| 5| 0| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 2| 1| 2| 2| 3| 8| 2| 3| 8| 0| 1| 8| 8| 4| 8| 2| 2| 8| 2| 2| | |
| 9| 8| 9| 9| 0| 3| 0| 0| 0| 7| 9| 8| 8| 9| 0| 9| 9| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
39 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Mononuclear Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + M + + + + + + | 19 |
Developmental Malformation | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + A + + + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Emphysema | 2 | 1 2.0|
Fibrosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Fungus | 2 | 1 2.0|
Inflammation, Suppurative | 3 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy | 4 3 4 3 3 2 4 3 3 1 3 3 3 1 4 3 4 4 2 4 | 20 3.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 3| 4| 3| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 5| 5| 5| 7| 5| 5| 5| | |
| 7| 3| 8| 5| 6| 5| 1| 5| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
Fatty Change | 1 1 | 2 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 3 |
Fat, Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis, Coagulative | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 2 2 2 2 2 2 2 | 8 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Distalis, Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 3| 4| 3| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 5| 5| 5| 7| 5| 5| 5| | |
| 7| 3| 8| 5| 6| 5| 1| 5| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Interstitial Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Ectopic Tissue | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + + + | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Edema | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 3| 4| 3| 4| 4| 4| 0| 4| 4| 4| | |
DAY ON TEST | 3| 5| 3| 5| 5| 5| 7| 5| 5| 5| | |
| 7| 3| 8| 5| 6| 5| 1| 5| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 2 1 1 1 1 3 2 2 | 9 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 3| 3| 6| 6| 6| 5| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Fatty Change | 2 2 1 1 1 2 1 2 3 | 9 1.7|
Necrosis, Coagulative | 1 1 | 2 1.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
Hepatocyte, Degeneration, Granular | 1 2 2 1 1 1 1 2 | 8 1.4|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 2 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 3| 3| 6| 6| 6| 5| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Hydronephrosis | 3 | 1 3.0|
Nephropathy | 2 3 3 3 2 3 3 3 3 3 | 10 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 3| 3| 6| 6| 6| 5| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 0| 5| 7| 6| 6| 7| 6| 6| 5| 4| 4| 6| 0| 5| 5| 0| 2| | |
DAY ON TEST | 6| 2| 3| 4| 6| 2| 3| 2| 2| 0| 1| 9| 9| 9| 1| 7| 8| 8| 4| 5| | |
| 5| 9| 9| 0| 6| 6| 9| 3| 9| 9| 8| 3| 6| 9| 8| 0| 5| 8| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M + | 19 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | X | 1 |
Fatty Change | 1 1 1 | 3 1.0|
Fibrosis | 2 1 | 2 1.5|
Mixed Cell Focus | X | 1 |
Necrosis, Coagulative | 1 3 1 | 4 2.3|
Bile Duct, Hyperplasia | 1 2 2 1 1 1 1 2 2 1 1 3 1 1 | 14 1.4|
Hepatocyte, Degeneration, Granular | 1 | 1 1.0|
Periductular, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 4 |
Fat, Inflammation, Suppurative | 4 | 1 4.0|
Fat, Necrosis, Coagulative | 4 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + | 19 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 3 3 2 | 3 2.7|
Inflammation, Suppurative | 4 | 1 4.0|
Ulcer | 4 4 4 3 3 | 5 3.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
Dilatation | 2 | 1 2.0|
Mineralization | 3 4 | 2 3.5|
Ulcer | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 0| 5| 7| 6| 6| 7| 6| 6| 5| 4| 4| 6| 0| 5| 5| 0| 2| | |
DAY ON TEST | 6| 2| 3| 4| 6| 2| 3| 2| 2| 0| 1| 9| 9| 9| 1| 7| 8| 8| 4| 5| | |
| 5| 9| 9| 0| 6| 6| 9| 3| 9| 9| 8| 3| 6| 9| 8| 0| 5| 8| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 3 3 2 3 2 2 2 2 3 1 | 10 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + M + + + + + + + | 18 |
Hyperplasia | 3 2 4 3 3 3 3 3 | 8 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Dilatation | 3 | 1 3.0|
Inflammation, Suppurative | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 3 | 1 3.0|
Infarct | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 0| 5| 7| 6| 6| 7| 6| 6| 5| 4| 4| 6| 0| 5| 5| 0| 2| | |
DAY ON TEST | 6| 2| 3| 4| 6| 2| 3| 2| 2| 0| 1| 9| 9| 9| 1| 7| 8| 8| 4| 5| | |
| 5| 9| 9| 0| 6| 6| 9| 3| 9| 9| 8| 3| 6| 9| 8| 0| 5| 8| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + M + + + + + M + + + M | 16 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
Cyst Epithelial Inclusion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
Cerebellum, Hemorrhage | 3 | 1 3.0|
Cerebrum, Hemorrhage | 3 | 1 3.0|
Cerebrum, Infarct | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Foreign Body | 1 1 1 | 3 1.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Fungus | 3 3 | 2 3.0|
Inflammation, Suppurative | 2 2 3 | 3 2.3|
Metaplasia, Squamous | 2 | 1 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
Metaplasia, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Posterior Chamber, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05090-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:53:18
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 0| 5| 7| 6| 6| 7| 6| 6| 5| 4| 4| 6| 0| 5| 5| 0| 2| | |
DAY ON TEST | 6| 2| 3| 4| 6| 2| 3| 2| 2| 0| 1| 9| 9| 9| 1| 7| 8| 8| 4| 5| | |
| 5| 9| 9| 0| 6| 6| 9| 3| 9| 9| 8| 3| 6| 9| 8| 0| 5| 8| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy | 4 4 4 1 4 4 4 4 4 3 4 4 4 3 4 1 4 4 1 2 | 20 3.4|
Cortex, Cyst | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Lumen, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
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---------- END OF REPORT ----------
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