TDMS Study 05090-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics Cor COUMARIN DATE: 10/22/97
EXPERIMENT: 05090 TEST: 01 TIME: 13:56:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES45039 ROUTE: GAVAGE NTP C#: 07103B
PATHOLOGIST: R. DAHLGREN CAS: 000091645
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 002 VEHICLE CONTROL
INCLUDE 003 25 MG/KG
INCLUDE 004 25 MG/KG
INCLUDE 005 50 MG/KG
INCLUDE 006 50 MG/KG
INCLUDE 007 100MG/KG
INCLUDE 008 100MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics Cor COUMARIN DATE: 10/22/97
EXPERIMENT: 05090 TEST: 01 TIME: 13:56:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES45039 ROUTE: GAVAGE NTP C#: 07103B
PATHOLOGIST: R. DAHLGREN CAS: 000091645
COUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 12 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 372 408 420 472 513 573 578 586 601 609 |
| 611 622 623 660 671 694 699 704 720 728 |
| CENSORED DEATHS |
| 5 335 453 453 453 455 455 455 455 455 |
| 455 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 38 CENSORED DEATHS 13 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 343 482 492 503 518 569 577 583 593 600 |
| 600 611 613 615 622 625 625 631 636 639 |
| 645 645 652 657 660 661 663 666 671 671 |
| 673 675 675 680 692 694 698 719 |
| CENSORED DEATHS |
| 90 352 377 453 453 453 453 455 455 455 |
| 455 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 47 CENSORED DEATHS 11 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 408 429 473 496 498 506 506 512 517 525 |
| 531 531 533 539 545 546 548 555 556 569 |
| 575 580 580 588 594 596 596 601 602 607 |
| 615 615 622 622 622 625 628 630 631 643 |
| 643 645 657 666 678 679 694 |
| CENSORED DEATHS |
| 63 428 453 453 453 453 455 455 455 455 |
| 456 |
| |
==================================================================================
COUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 48 CENSORED DEATHS 12 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 307 380 420 456 477 485 492 496 496 503 |
| 510 511 512 517 518 518 525 533 534 551 |
| 552 552 560 563 566 567 572 580 580 589 |
| 595 601 607 611 611 615 618 618 630 631 |
| 636 638 643 646 650 654 660 698 |
| CENSORED DEATHS |
| 19 426 453 453 453 453 455 455 455 455 |
| 456 456 |
| |
==================================================================================
COUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 94.8 92.7 90.6 82.2 71.6 59.0 |
|CONTROL | |
| | |
|25 MG/KG | 100.0 100.0 100.0 98.3 98.3 96.2 89.8 76.9 42.7 19.2 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 98.3 94.5 69.9 41.1 12.3 4.1 |
| | |
| | |
|100MG/KG | 100.0 100.0 100.0 98.3 94.9 88.7 61.2 33.8 2.1 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 25 MG/KG 50 MG/KG 100MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.0% 19.2% 4.1% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P