TDMS Study 05090-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: American Biogenics Cor COUMARIN DATE: 10/22/97 EXPERIMENT: 05090 TEST: 01 TIME: 13:56:48 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01ES45039 ROUTE: GAVAGE NTP C#: 07103B PATHOLOGIST: R. DAHLGREN CAS: 000091645 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL INCLUDE 002 VEHICLE CONTROL INCLUDE 003 25 MG/KG INCLUDE 004 25 MG/KG INCLUDE 005 50 MG/KG INCLUDE 006 50 MG/KG INCLUDE 007 100MG/KG INCLUDE 008 100MG/KG NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: American Biogenics Cor COUMARIN DATE: 10/22/97 EXPERIMENT: 05090 TEST: 01 TIME: 13:56:48 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01ES45039 ROUTE: GAVAGE NTP C#: 07103B PATHOLOGIST: R. DAHLGREN CAS: 000091645 COUMARIN STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = VEHICLE CONTROL | | ---------------------------- | | | | TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 12 TERMINAL 28 | | | | UNCENSORED DEATHS | | 372 408 420 472 513 573 578 586 601 609 | | 611 622 623 660 671 694 699 704 720 728 | | CENSORED DEATHS | | 5 335 453 453 453 455 455 455 455 455 | | 455 456 | | | |--------------------------------------------------------------------------------| | DOSE = 25 MG/KG | | --------------------- | | | | TOTAL 60 UNCENSORED DEATHS 38 CENSORED DEATHS 13 TERMINAL 9 | | | | UNCENSORED DEATHS | | 343 482 492 503 518 569 577 583 593 600 | | 600 611 613 615 622 625 625 631 636 639 | | 645 645 652 657 660 661 663 666 671 671 | | 673 675 675 680 692 694 698 719 | | CENSORED DEATHS | | 90 352 377 453 453 453 453 455 455 455 | | 455 456 456 | | | |--------------------------------------------------------------------------------| | DOSE = 50 MG/KG | | --------------------- | | | | TOTAL 60 UNCENSORED DEATHS 47 CENSORED DEATHS 11 TERMINAL 2 | | | | UNCENSORED DEATHS | | 408 429 473 496 498 506 506 512 517 525 | | 531 531 533 539 545 546 548 555 556 569 | | 575 580 580 588 594 596 596 601 602 607 | | 615 615 622 622 622 625 628 630 631 643 | | 643 645 657 666 678 679 694 | | CENSORED DEATHS | | 63 428 453 453 453 453 455 455 455 455 | | 456 | | | ================================================================================== COUMARIN STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 100MG/KG | | --------------------- | | | | TOTAL 60 UNCENSORED DEATHS 48 CENSORED DEATHS 12 TERMINAL 0 | | | | UNCENSORED DEATHS | | 307 380 420 456 477 485 492 496 496 503 | | 510 511 512 517 518 518 525 533 534 551 | | 552 552 560 563 566 567 572 580 580 589 | | 595 601 607 611 611 615 618 618 630 631 | | 636 638 643 646 650 654 660 698 | | CENSORED DEATHS | | 19 426 453 453 453 453 455 455 455 455 | | 456 456 | | | ================================================================================== COUMARIN STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 729 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 729 (A) | | | |--------------------------------------------------------------------------------| | | | |VEHICLE | 100.0 100.0 100.0 100.0 94.8 92.7 90.6 82.2 71.6 59.0 | |CONTROL | | | | | |25 MG/KG | 100.0 100.0 100.0 98.3 98.3 96.2 89.8 76.9 42.7 19.2 | | | | | | | |50 MG/KG | 100.0 100.0 100.0 100.0 98.3 94.5 69.9 41.1 12.3 4.1 | | | | | | | |100MG/KG | 100.0 100.0 100.0 98.3 94.9 88.7 61.2 33.8 2.1 0.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | VEHICLE 25 MG/KG 50 MG/KG 100MG/KG | | CONTROL | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 59.0% 19.2% 4.1% 0.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P