https://ntp.niehs.nih.gov/go/1139

TDMS Study 05090-01 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: American Biogenics Cor                                     COUMARIN                                       DATE: 10/22/97       
EXPERIMENT: 05090 TEST: 01                                                                                     TIME: 13:56:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES45039                                ROUTE: GAVAGE                                                  NTP C#: 07103B       
PATHOLOGIST: R. DAHLGREN                                                                                       CAS: 000091645       
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               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL                                                               
                                       INCLUDE 002    VEHICLE CONTROL                                                               
                                       INCLUDE 003    25 MG/KG                                                                      
                                       INCLUDE 004    25 MG/KG                                                                      
                                       INCLUDE 005    50 MG/KG                                                                      
                                       INCLUDE 006    50 MG/KG                                                                      
                                       INCLUDE 007    100MG/KG                                                                      
                                       INCLUDE 008    100MG/KG                                                                      
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: American Biogenics Cor                                     COUMARIN                                       DATE: 10/22/97      
EXPERIMENT: 05090 TEST: 01                                                                                     TIME: 13:56:48      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES45039                                ROUTE: GAVAGE                                                  NTP C#: 07103B      
PATHOLOGIST: R. DAHLGREN                                                                                       CAS: 000091645      
                                     COUMARIN
                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 12   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      372   408   420   472   513   573   578   586   601   609                 |
 |      611   622   623   660   671   694   699   704   720   728                 |
 |  CENSORED DEATHS                                                               |
 |      5     335   453   453   453   455   455   455   455   455                 |
 |      455   456                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 38     CENSORED DEATHS 13   TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      343   482   492   503   518   569   577   583   593   600                 |
 |      600   611   613   615   622   625   625   631   636   639                 |
 |      645   645   652   657   660   661   663   666   671   671                 |
 |      673   675   675   680   692   694   698   719                             |
 |  CENSORED DEATHS                                                               |
 |      90    352   377   453   453   453   453   455   455   455                 |
 |      455   456   456                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 47     CENSORED DEATHS 11   TERMINAL 2         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      408   429   473   496   498   506   506   512   517   525                 |
 |      531   531   533   539   545   546   548   555   556   569                 |
 |      575   580   580   588   594   596   596   601   602   607                 |
 |      615   615   622   622   622   625   628   630   631   643                 |
 |      643   645   657   666   678   679   694                                   |
 |  CENSORED DEATHS                                                               |
 |      63    428   453   453   453   453   455   455   455   455                 |
 |      456                                                                       |
 |                                                                                |
 ==================================================================================
                                     COUMARIN
                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 100MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 48     CENSORED DEATHS 12   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      307   380   420   456   477   485   492   496   496   503                 |
 |      510   511   512   517   518   518   525   533   534   551                 |
 |      552   552   560   563   566   567   572   580   580   589                 |
 |      595   601   607   611   611   615   618   618   630   631                 |
 |      636   638   643   646   650   654   660   698                             |
 |  CENSORED DEATHS                                                               |
 |      19    426   453   453   453   453   455   455   455   455                 |
 |      456   456                                                                 |
 |                                                                                |
 ==================================================================================
                                     COUMARIN
                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  94.8  92.7  90.6  82.2  71.6  59.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |25 MG/KG   |   100.0 100.0 100.0  98.3  98.3  96.2  89.8  76.9  42.7  19.2      |
 |           |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |   100.0 100.0 100.0 100.0  98.3  94.5  69.9  41.1  12.3   4.1      |
 |           |                                                                    |
 |           |                                                                    |
 |100MG/KG   |   100.0 100.0 100.0  98.3  94.9  88.7  61.2  33.8   2.1   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      25 MG/KG     50 MG/KG     100MG/KG |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       59.0%        19.2%         4.1%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P