TDMS Study 05091-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DIHYDROCOUMARIN
NTP Experiment-Test: 05091-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/12/94
Route: GAVAGE Time: 13:00:25
Facility: American Biogenics Corp.
Chemical CAS #: 119-84-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 19 20 19 18
Early Deaths
Gavage Death 2
Moribund 5 9 4 5
Dead 8 2 5 18
Accident 1
Survivors
Terminal Sacrifice 36 39 41 28
Dead 1
Animals Examined Microscopically 60 56 58 61
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (54) (50) (44) (42)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (53) (50) (46) (49)
Hyperplasia, Lymphoid 1 (2%) 6 (12%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Intestine Large, Colon (54) (50) (46) (49)
Edema 1 (2%)
Intestine Small, Duodenum (54) (50) (46) (46)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (54) (50) (45) (49)
Hyperplasia, Lymphoid 2 (4%)
Intestine Small, Jejunum (56) (50) (45) (48)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Liver (60) (50) (53) (61)
Autolysis 1 (2%)
Basophilic Focus 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Clear Cell Focus 2 (4%) 2 (4%)
Eosinophilic Focus 8 (13%) 11 (22%) 9 (17%) 8 (13%)
Infiltration Cellular, Lymphocyte 9 (15%) 8 (16%) 8 (15%) 5 (8%)
Inflammation, Chronic 2 (3%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Necrosis 2 (3%) 2 (4%) 1 (2%) 3 (5%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Central Vein, Dilatation 1 (2%)
Perivascular, Fibrosis 1 (2%)
Mesentery (2) (3) (2) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Infiltration Cellular, Lymphocyte 1 (33%)
Fat, Inflammation, Chronic Active 1 (50%) 1 (33%)
Fat, Necrosis 1 (50%) 2 (67%) 2 (100%) 1 (50%)
Pancreas (59) (50) (48) (56)
Atrophy 2 (3%) 1 (2%) 3 (5%)
Infiltration Cellular, Lymphocyte 10 (17%) 13 (26%) 10 (21%) 12 (21%)
Inflammation, Suppurative 1 (2%)
Duct, Dilatation 1 (2%)
Salivary Glands (60) (50) (50) (59)
Infiltration Cellular, Lymphocyte 21 (35%) 20 (40%) 23 (46%) 23 (39%)
Stomach, Forestomach (58) (50) (48) (57)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 14 (24%) 6 (12%) 9 (19%) 6 (11%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Inflammation, Suppurative 12 (21%) 2 (4%) 2 (4%) 3 (5%)
Stomach, Glandular (53) (50) (45) (50)
Infiltration Cellular, Lymphocyte 2 (4%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (50) (50) (60)
Cardiomyopathy 3 (6%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 4 (7%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (3%)
Necrosis 1 (2%)
Polyarteritis 2 (4%)
Atrioventricular Valve, Fibrosis 1 (2%)
Atrium, Thrombosis 1 (2%)
Valve, Pigmentation, Melanin, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (58) (50) (47) (57)
Corticomedullary Junction, Hemorrhage 2 (3%)
Adrenal Gland, Cortex (58) (50) (47) (57)
Congestion 1 (2%)
Cyst 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hypertrophy 1 (2%) 1 (2%) 1 (2%)
Pigmentation, Ceroid 1 (2%) 1 (2%)
Adrenal Gland, Medulla (56) (50) (47) (57)
Congestion 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 1 (2%)
Necrosis 1 (2%)
Islets, Pancreatic (59) (50) (48) (56)
Infiltration Cellular, Lymphocyte 1 (2%)
Parathyroid Gland (46) (38) (33) (47)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (56) (48) (47) (56)
Congestion 1 (2%)
Pars Distalis, Cyst 2 (4%)
Pars Distalis, Hyperplasia 1 (2%) 2 (4%)
Pars Distalis, Hypertrophy 1 (2%)
Thyroid Gland (57) (50) (49) (58)
Infiltration Cellular, Lymphocyte 2 (4%) 2 (3%)
Inflammation, Suppurative 1 (2%)
Follicle, Cyst 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 5 (9%) 2 (4%) 2 (4%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Fat, Pelvic, Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (59) (51) (50) (59)
Pigmentation, Ceroid 2 (3%) 1 (2%) 1 (2%)
Follicle, Cyst 11 (19%) 10 (20%) 10 (20%) 9 (15%)
Follicle, Hematocyst 5 (8%) 12 (24%) 4 (8%) 5 (8%)
Periovarian Tissue, Hemorrhage 1 (2%)
Uterus (60) (56) (56) (60)
Congestion 1 (2%) 1 (2%)
Hydrometra 3 (5%) 3 (5%) 5 (9%) 6 (10%)
Hyperplasia, Cystic 46 (77%) 52 (93%) 47 (84%) 47 (78%)
Inflammation, Suppurative 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (50) (48) (56)
Hyperplasia, Erythrocyte 1 (2%)
Hyperplasia, Mononuclear Cell 1 (2%)
Hyperplasia, Neutrophil 1 (2%) 1 (2%)
Lymph Node (59) (50) (48) (57)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Lymph Node, Mandibular (57) (48) (40) (51)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 4 (8%) 3 (8%) 1 (2%)
Hyperplasia, Macrophage 1 (2%)
Lymph Node, Mesenteric (56) (50) (45) (49)
Congestion 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 6 (12%) 4 (9%) 1 (2%)
Hyperplasia, Macrophage 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Spleen (60) (50) (49) (55)
Congestion 1 (2%)
Developmental Malformation 2 (3%) 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Erythrocyte 1 (2%)
Hyperplasia, Lymphoid 12 (20%) 12 (24%) 6 (12%) 3 (5%)
Hyperplasia, Macrophage 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Capsule, Fibrosis 1 (2%)
Thymus (54) (48) (47) (57)
Atrophy 1 (2%) 2 (4%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%) 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (47) (48) (59)
Lactation 3 (5%) 1 (2%)
Skin (60) (52) (50) (60)
Alopecia 7 (12%) 2 (4%) 5 (10%) 3 (5%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (50) (50) (61)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Osteopetrosis 1 (2%) 1 (2%)
Skeletal Muscle (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (50) (47) (57)
Compression 2 (3%) 2 (4%)
Hydrocephalus 1 (2%) 1 (2%)
Cerebellum, Necrosis, Coagulative 1 (2%)
Meninges, Inflammation, Suppurative 1 (2%)
Spinal Cord (1)
Degeneration 1 (100%)
Demyelination 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (50) (48) (60)
Congestion 1 (2%)
Hemorrhage 3 (5%) 1 (2%)
Hyperplasia, Macrophage 1 (2%)
Infiltration Cellular, Lymphocyte 2 (3%) 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 2 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Nose (60) (50) (50) (60)
Inflammation, Suppurative 1 (2%) 1 (2%)
Trachea (59) (50) (49) (60)
Infiltration Cellular, Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Inflammation, Suppurative 1 (100%)
Eye (3) (2) (1)
Cornea, Edema 1 (33%)
Harderian Gland (2) (3) (3) (1)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (50) (48) (56)
Fatty Change 1 (2%)
Glomerulosclerosis 1 (2%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 12 (21%) 7 (14%) 10 (21%) 9 (16%)
Metaplasia, Cartilagenous 1 (2%) 1 (2%)
Necrosis, Coagulative 2 (4%) 3 (6%) 1 (2%)
Nephropathy 5 (10%) 4 (8%) 5 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cortex, Cyst 1 (2%) 1 (2%)
Urinary Bladder (54) (50) (47) (54)
Dilatation 1 (2%)
Infiltration Cellular, Lymphocyte 17 (31%) 22 (44%) 19 (40%) 19 (35%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 19 19 20
Early Deaths
Gavage Death 1 1 1
Dead 4 8 8 8
Moribund 3 3 8 4
Survivors
Terminal Sacrifice 42 39 34 38
Animals Examined Microscopically 60 58 56 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (55) (40) (41) (48)
Hemorrhage 1 (3%)
Intestine Large, Cecum (57) (46) (43) (54)
Hyperplasia, Lymphoid 6 (11%) 2 (4%) 8 (19%) 3 (6%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Intestine Large, Rectum (54) (46) (43) (56)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Suppurative 1 (2%)
Intestine Small, Ileum (57) (46) (43) (54)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (57) (45) (43) (54)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Liver (60) (56) (55) (60)
Angiectasis 1 (2%) 4 (7%)
Basophilic Focus 3 (5%) 1 (2%) 5 (9%) 4 (7%)
Clear Cell Focus 3 (5%) 7 (13%) 14 (25%) 7 (12%)
Eosinophilic Focus 9 (15%) 8 (14%) 13 (24%) 12 (20%)
Fatty Change 2 (3%) 2 (4%) 1 (2%) 3 (5%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%) 1 (2%) 2 (3%)
Necrosis 3 (5%) 3 (5%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Mesentery (3) (3) (2) (1)
Fat, Inflammation, Chronic Active 2 (100%)
Fat, Inflammation, Suppurative 1 (33%)
Fat, Necrosis 2 (67%) 2 (67%) 1 (50%) 1 (100%)
Pancreas (58) (50) (48) (59)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 4 (7%) 2 (4%) 2 (4%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%)
Polyarteritis 1 (2%)
Salivary Glands (60) (50) (50) (59)
Infiltration Cellular, Lymphocyte 21 (35%) 23 (46%) 18 (36%) 15 (25%)
Duct, Dilatation 1 (2%)
Stomach (59) (49) (46) (58)
Serosa, Inflammation, Suppurative 1 (2%)
Stomach, Forestomach (59) (49) (46) (58)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 2 (3%)
Hyperplasia, Squamous 10 (17%) 8 (16%) 9 (20%) 16 (28%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 4 (7%) 4 (8%) 1 (2%) 6 (10%)
Stomach, Glandular (58) (47) (43) (56)
Cyst 1 (2%)
Inflammation, Suppurative 2 (4%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (51) (51) (60)
Cardiomyopathy 2 (3%) 5 (10%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (4%)
Atrium, Thrombosis 1 (2%) 1 (2%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (50) (48) (59)
Capsule, Inflammation, Suppurative 1 (2%)
Adrenal Gland, Cortex (59) (50) (48) (59)
Accessory Adrenal Cortical Nodule 1 (2%)
Hyperplasia 3 (5%) 1 (2%) 1 (2%)
Hypertrophy 4 (7%) 7 (14%) 1 (2%) 5 (8%)
Infarct 1 (2%)
Pigmentation, Ceroid 1 (2%)
Adrenal Gland, Medulla (59) (49) (48) (57)
Hyperplasia 4 (7%) 2 (4%) 1 (2%) 2 (4%)
Islets, Pancreatic (59) (50) (49) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%)
Pituitary Gland (56) (46) (45) (55)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (59) (49) (49) (60)
Follicle, Cyst 1 (2%)
Follicle, Degeneration 1 (2%)
Follicular Cell, Hyperplasia 2 (3%) 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (5) (1)
Hemorrhage 1 (20%)
Necrosis 1 (100%) 1 (20%)
Abdominal, Inflammation, Suppurative 1 (20%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (59) (49) (48) (59)
Granuloma Sperm 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Mineralization 1 (2%)
Preputial Gland (12) (10) (13) (11)
Inflammation, Chronic 1 (8%) 1 (9%)
Inflammation, Suppurative 1 (8%) 3 (30%) 1 (9%)
Duct, Dilatation 11 (92%) 7 (70%) 13 (100%) 9 (82%)
Prostate (60) (47) (48) (60)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (59) (48) (47) (58)
Dilatation 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Testes (59) (48) (48) (58)
Atrophy 1 (2%) 1 (2%) 3 (6%) 2 (3%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (51) (50) (59)
Hyperplasia, Neutrophil 1 (2%) 1 (2%)
Lymph Node (60) (49) (51) (60)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (56) (41) (49) (54)
Hyperplasia, Lymphoid 2 (5%) 5 (10%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Macrophage 1 (2%)
Lymph Node, Mesenteric (59) (48) (44) (57)
Congestion 5 (8%) 1 (2%) 4 (9%) 1 (2%)
Hemorrhage 2 (4%)
Inflammation, Suppurative 1 (2%)
Sinus, Dilatation 1 (2%)
Spleen (59) (50) (47) (58)
Congestion 1 (2%) 1 (2%)
Cyst 1 (2%)
Developmental Malformation 2 (3%) 1 (2%) 1 (2%) 6 (10%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 5 (8%) 4 (8%) 4 (9%) 2 (3%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Inflammation, Pyogranulomatous 1 (2%)
Thymus (51) (49) (39) (56)
Atrophy 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (59) (50) (49) (58)
Alopecia 4 (7%) 2 (4%) 3 (6%) 3 (5%)
Cyst Epithelial Inclusion 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Parakeratosis 1 (2%)
Ulcer 1 (2%)
Sebaceous Gland, Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (51) (51) (60)
Hyperostosis 1 (2%)
Inflammation, Suppurative 1 (2%)
Skeletal Muscle (1) (2)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (49) (48) (60)
Infiltration Cellular, Lymphocyte 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (52) (53) (60)
Congestion 1 (2%) 2 (4%) 2 (4%)
Edema 1 (2%) 1 (2%)
Emphysema 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Macrophage 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 4 (8%) 2 (3%)
Alveolus, Giant Cell 1 (2%)
Peribronchiolar, Infiltration Cellular,
Lymphocyte 1 (2%)
Nose (60) (51) (50) (60)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (3%)
Nasolacrimal Duct, Hyperplasia, Squamous 1 (2%)
Vomeronasal Organ, Inflammation,
Proliferative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Pinna, Hyperplasia, Squamous 1 (50%)
Pinna, Inflammation, Suppurative 2 (100%)
Eye (3) (3) (2) (2)
Cataract 1 (33%) 1 (33%) 1 (50%)
Anterior Chamber, Edema 1 (50%)
Cornea, Edema 1 (50%)
Cornea, Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (51) (51) (59)
Amyloid Deposition 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 6 (10%) 1 (2%) 3 (6%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05091-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 13:00:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 200MG/KG 400MG/KG 800MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%)
Nephropathy 45 (75%) 46 (90%) 45 (88%) 43 (73%)
Cortex, Cyst 2 (3%) 1 (2%) 5 (10%) 4 (7%)
Medulla, Mineralization 1 (2%)
Pelvis, Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia, Cystic 2 (3%) 1 (2%) 4 (8%) 2 (3%)
Urinary Bladder (60) (47) (46) (58)
Dilatation 1 (2%)
Infiltration Cellular, Lymphocyte 2 (3%) 4 (9%) 5 (11%) 3 (5%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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