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https://ntp.niehs.nih.gov/go/1141

TDMS Study 05091-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          DIHYDROCOUMARIN


NTP Experiment-Test: 05091-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 13:00:25




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 19           20           19           18                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       2                                                                            
    Moribund                                           5            9            4            5                                     
    Dead                                               8            2            5           18                                     
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           39           41           28                                     
    Dead                                                                                      1                                     
  Animals Examined Microscopically                    60           56           58           61                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (54)         (50)         (44)         (42)                                   
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Large, Cecum                             (53)         (50)         (46)         (49)                                   
      Hyperplasia, Lymphoid                            1 (2%)       6 (12%)      2 (4%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
   Intestine Large, Colon                             (54)         (50)         (46)         (49)                                   
      Edema                                            1 (2%)                                                                       
   Intestine Small, Duodenum                          (54)         (50)         (46)         (46)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Intestine Small, Ileum                             (54)         (50)         (45)         (49)                                   
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Intestine Small, Jejunum                           (56)         (50)         (45)         (48)                                   
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                                                          
   Liver                                              (60)         (50)         (53)         (61)                                   
      Autolysis                                                                  1 (2%)                                             
      Basophilic Focus                                 1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Clear Cell Focus                                              2 (4%)       2 (4%)                                             
      Eosinophilic Focus                               8 (13%)     11 (22%)      9 (17%)      8 (13%)                               
      Infiltration Cellular, Lymphocyte                9 (15%)      8 (16%)      8 (15%)      5 (8%)                                
      Inflammation, Chronic                            2 (3%)                                                                       
      Inflammation, Suppurative                                                  2 (4%)       1 (2%)                                
      Mixed Cell Focus                                 1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Necrosis                                         2 (3%)       2 (4%)       1 (2%)       3 (5%)                                
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)                                                          
      Bile Duct, Cyst                                  1 (2%)       1 (2%)                                                          
      Central Vein, Dilatation                         1 (2%)                                                                       
      Perivascular, Fibrosis                                                                  1 (2%)                                
   Mesentery                                          (2)          (3)          (2)          (2)                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Infiltration Cellular, Lymphocyte                        1 (33%)                                                         
      Fat, Inflammation, Chronic Active                1 (50%)      1 (33%)                                                         
      Fat, Necrosis                                    1 (50%)      2 (67%)      2 (100%)     1 (50%)                               
   Pancreas                                           (59)         (50)         (48)         (56)                                   
      Atrophy                                          2 (3%)                    1 (2%)       3 (5%)                                
      Infiltration Cellular, Lymphocyte               10 (17%)     13 (26%)     10 (21%)     12 (21%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Duct, Dilatation                                                                        1 (2%)                                
   Salivary Glands                                    (60)         (50)         (50)         (59)                                   
      Infiltration Cellular, Lymphocyte               21 (35%)     20 (40%)     23 (46%)     23 (39%)                               
   Stomach, Forestomach                               (58)         (50)         (48)         (57)                                   
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Squamous                           14 (24%)      6 (12%)      9 (19%)      6 (11%)                               
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                             
      Inflammation, Suppurative                       12 (21%)      2 (4%)       2 (4%)       3 (5%)                                
   Stomach, Glandular                                 (53)         (50)         (45)         (50)                                   
      Infiltration Cellular, Lymphocyte                                          2 (4%)                                             
      Mineralization                                   1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (50)         (50)         (60)                                   
      Cardiomyopathy                                                3 (6%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                    4 (7%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)       2 (4%)                    2 (3%)                                
      Necrosis                                                                                1 (2%)                                
      Polyarteritis                                                 2 (4%)                                                          
      Atrioventricular Valve, Fibrosis                                                        1 (2%)                                
      Atrium, Thrombosis                                            1 (2%)                                                          
      Valve, Pigmentation, Melanin, Multifocal         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (58)         (50)         (47)         (57)                                   
      Corticomedullary Junction, Hemorrhage            2 (3%)                                                                       
   Adrenal Gland, Cortex                              (58)         (50)         (47)         (57)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Hypertrophy                                      1 (2%)       1 (2%)       1 (2%)                                             
      Pigmentation, Ceroid                             1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (56)         (50)         (47)         (57)                                   
      Congestion                                       1 (2%)                                 1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
   Islets, Pancreatic                                 (59)         (50)         (48)         (56)                                   
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
   Parathyroid Gland                                  (46)         (38)         (33)         (47)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (56)         (48)         (47)         (56)                                   
      Congestion                                       1 (2%)                                                                       
      Pars Distalis, Cyst                                                                     2 (4%)                                
      Pars Distalis, Hyperplasia                                    1 (2%)                    2 (4%)                                
      Pars Distalis, Hypertrophy                       1 (2%)                                                                       
   Thyroid Gland                                      (57)         (50)         (49)         (58)                                   
      Infiltration Cellular, Lymphocyte                                          2 (4%)       2 (3%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Follicle, Cyst                                                1 (2%)       2 (4%)                                             
      Follicular Cell, Hyperplasia                     5 (9%)       2 (4%)       2 (4%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)          (1)                                    
      Fat, Pelvic, Hemorrhage                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (51)         (50)         (59)                                   
      Pigmentation, Ceroid                             2 (3%)       1 (2%)                    1 (2%)                                
      Follicle, Cyst                                  11 (19%)     10 (20%)     10 (20%)      9 (15%)                               
      Follicle, Hematocyst                             5 (8%)      12 (24%)      4 (8%)       5 (8%)                                
      Periovarian Tissue, Hemorrhage                                1 (2%)                                                          
   Uterus                                             (60)         (56)         (56)         (60)                                   
      Congestion                                                    1 (2%)                    1 (2%)                                
      Hydrometra                                       3 (5%)       3 (5%)       5 (9%)       6 (10%)                               
      Hyperplasia, Cystic                             46 (77%)     52 (93%)     47 (84%)     47 (78%)                               
      Inflammation, Suppurative                        2 (3%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (48)         (56)                                   
      Hyperplasia, Erythrocyte                                                   1 (2%)                                             
      Hyperplasia, Mononuclear Cell                    1 (2%)                                                                       
      Hyperplasia, Neutrophil                          1 (2%)       1 (2%)                                                          
   Lymph Node                                         (59)         (50)         (48)         (57)                                   
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)       1 (2%)       2 (4%)                                             
   Lymph Node, Mandibular                             (57)         (48)         (40)         (51)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            3 (5%)       4 (8%)       3 (8%)       1 (2%)                                
      Hyperplasia, Macrophage                          1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (50)         (45)         (49)                                   
      Congestion                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       6 (12%)      4 (9%)       1 (2%)                                
      Hyperplasia, Macrophage                          1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
   Spleen                                             (60)         (50)         (49)         (55)                                   
      Congestion                                                                              1 (2%)                                
      Developmental Malformation                       2 (3%)       3 (6%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Hyperplasia, Erythrocyte                                                   1 (2%)                                             
      Hyperplasia, Lymphoid                           12 (20%)     12 (24%)      6 (12%)      3 (5%)                                
      Hyperplasia, Macrophage                          1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Capsule, Fibrosis                                1 (2%)                                                                       
   Thymus                                             (54)         (48)         (47)         (57)                                   
      Atrophy                                                                    1 (2%)       2 (4%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (47)         (48)         (59)                                   
      Lactation                                        3 (5%)                                 1 (2%)                                
   Skin                                               (60)         (52)         (50)         (60)                                   
      Alopecia                                         7 (12%)      2 (4%)       5 (10%)      3 (5%)                                
      Hyperplasia, Squamous                                                      1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (50)         (61)                                   
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Osteopetrosis                                                 1 (2%)       1 (2%)                                             
   Skeletal Muscle                                                              (1)                                                 
      Necrosis                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (50)         (47)         (57)                                   
      Compression                                      2 (3%)                                 2 (4%)                                
      Hydrocephalus                                    1 (2%)       1 (2%)                                                          
      Cerebellum, Necrosis, Coagulative                             1 (2%)                                                          
      Meninges, Inflammation, Suppurative              1 (2%)                                                                       
   Spinal Cord                                                                  (1)                                                 
      Degeneration                                                               1 (100%)                                           
      Demyelination                                                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (48)         (60)                                   
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                       3 (5%)                                 1 (2%)                                
      Hyperplasia, Macrophage                                                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (3%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                        2 (3%)                                                                       
      Alveolar Epithelium, Hyperplasia                                                        1 (2%)                                
   Nose                                               (60)         (50)         (50)         (60)                                   
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)                                
   Trachea                                            (59)         (50)         (49)         (60)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
   Eye                                                (3)          (2)          (1)                                                 
      Cornea, Edema                                    1 (33%)                                                                      
   Harderian Gland                                    (2)          (3)          (3)          (1)                                    
      Inflammation, Suppurative                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (50)         (48)         (56)                                   
      Fatty Change                                                                            1 (2%)                                
      Glomerulosclerosis                               1 (2%)                    1 (2%)                                             
      Infarct                                                                                 1 (2%)                                
      Infiltration Cellular, Lymphocyte               12 (21%)      7 (14%)     10 (21%)      9 (16%)                               
      Metaplasia, Cartilagenous                                                  1 (2%)       1 (2%)                                
      Necrosis, Coagulative                                         2 (4%)       3 (6%)       1 (2%)                                
      Nephropathy                                                   5 (10%)      4 (8%)       5 (9%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cortex, Cyst                                     1 (2%)                                 1 (2%)                                
   Urinary Bladder                                    (54)         (50)         (47)         (54)                                   
      Dilatation                                                                 1 (2%)                                             
      Infiltration Cellular, Lymphocyte               17 (31%)     22 (44%)     19 (40%)     19 (35%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           19           19           20                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       1            1            1                                                  
    Dead                                               4            8            8            8                                     
    Moribund                                           3            3            8            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           39           34           38                                     
  Animals Examined Microscopically                    60           58           56           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (55)         (40)         (41)         (48)                                   
      Hemorrhage                                                    1 (3%)                                                          
   Intestine Large, Cecum                             (57)         (46)         (43)         (54)                                   
      Hyperplasia, Lymphoid                            6 (11%)      2 (4%)       8 (19%)      3 (6%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Large, Rectum                            (54)         (46)         (43)         (56)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Small, Ileum                             (57)         (46)         (43)         (54)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (57)         (45)         (43)         (54)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
   Liver                                              (60)         (56)         (55)         (60)                                   
      Angiectasis                                      1 (2%)       4 (7%)                                                          
      Basophilic Focus                                 3 (5%)       1 (2%)       5 (9%)       4 (7%)                                
      Clear Cell Focus                                 3 (5%)       7 (13%)     14 (25%)      7 (12%)                               
      Eosinophilic Focus                               9 (15%)      8 (14%)     13 (24%)     12 (20%)                               
      Fatty Change                                     2 (3%)       2 (4%)       1 (2%)       3 (5%)                                
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                     2 (4%)                    1 (2%)                                
      Mixed Cell Focus                                 1 (2%)       2 (4%)       1 (2%)       2 (3%)                                
      Necrosis                                                      3 (5%)       3 (5%)       1 (2%)                                
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Mesentery                                          (3)          (3)          (2)          (1)                                    
      Fat, Inflammation, Chronic Active                                          2 (100%)                                           
      Fat, Inflammation, Suppurative                   1 (33%)                                                                      
      Fat, Necrosis                                    2 (67%)      2 (67%)      1 (50%)      1 (100%)                              
   Pancreas                                           (58)         (50)         (48)         (59)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                          4 (7%)       2 (4%)       2 (4%)       1 (2%)                                
      Cyst                                             1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)       3 (6%)                    1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Polyarteritis                                                              1 (2%)                                             
   Salivary Glands                                    (60)         (50)         (50)         (59)                                   
      Infiltration Cellular, Lymphocyte               21 (35%)     23 (46%)     18 (36%)     15 (25%)                               
      Duct, Dilatation                                                           1 (2%)                                             
   Stomach                                            (59)         (49)         (46)         (58)                                   
      Serosa, Inflammation, Suppurative                1 (2%)                                                                       
   Stomach, Forestomach                               (59)         (49)         (46)         (58)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                                          2 (3%)                                
      Hyperplasia, Squamous                           10 (17%)      8 (16%)      9 (20%)     16 (28%)                               
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        4 (7%)       4 (8%)       1 (2%)       6 (10%)                               
   Stomach, Glandular                                 (58)         (47)         (43)         (56)                                   
      Cyst                                                          1 (2%)                                                          
      Inflammation, Suppurative                                     2 (4%)                                                          
      Mineralization                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (51)         (51)         (60)                                   
      Cardiomyopathy                                   2 (3%)                    5 (10%)      1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
      Mineralization                                                             2 (4%)                                             
      Atrium, Thrombosis                               1 (2%)       1 (2%)                                                          
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (50)         (48)         (59)                                   
      Capsule, Inflammation, Suppurative               1 (2%)                                                                       
   Adrenal Gland, Cortex                              (59)         (50)         (48)         (59)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Hyperplasia                                      3 (5%)       1 (2%)                    1 (2%)                                
      Hypertrophy                                      4 (7%)       7 (14%)      1 (2%)       5 (8%)                                
      Infarct                                                                    1 (2%)                                             
      Pigmentation, Ceroid                                                       1 (2%)                                             
   Adrenal Gland, Medulla                             (59)         (49)         (48)         (57)                                   
      Hyperplasia                                      4 (7%)       2 (4%)       1 (2%)       2 (4%)                                
   Islets, Pancreatic                                 (59)         (50)         (49)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (56)         (46)         (45)         (55)                                   
      Pars Distalis, Cyst                              1 (2%)                    1 (2%)       1 (2%)                                
   Thyroid Gland                                      (59)         (49)         (49)         (60)                                   
      Follicle, Cyst                                                             1 (2%)                                             
      Follicle, Degeneration                                        1 (2%)                                                          
      Follicular Cell, Hyperplasia                     2 (3%)                    2 (4%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (5)                       (1)                                    
      Hemorrhage                                                    1 (20%)                                                         
      Necrosis                                         1 (100%)     1 (20%)                                                         
      Abdominal, Inflammation, Suppurative                          1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)         (49)         (48)         (59)                                   
      Granuloma Sperm                                  1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
   Preputial Gland                                    (12)         (10)         (13)         (11)                                   
      Inflammation, Chronic                                                      1 (8%)       1 (9%)                                
      Inflammation, Suppurative                        1 (8%)       3 (30%)                   1 (9%)                                
      Duct, Dilatation                                11 (92%)      7 (70%)     13 (100%)     9 (82%)                               
   Prostate                                           (60)         (47)         (48)         (60)                                   
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
   Seminal Vesicle                                    (59)         (48)         (47)         (58)                                   
      Dilatation                                       1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Testes                                             (59)         (48)         (48)         (58)                                   
      Atrophy                                          1 (2%)       1 (2%)       3 (6%)       2 (3%)                                
      Mineralization                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (51)         (50)         (59)                                   
      Hyperplasia, Neutrophil                                       1 (2%)                    1 (2%)                                
   Lymph Node                                         (60)         (49)         (51)         (60)                                   
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
   Lymph Node, Mandibular                             (56)         (41)         (49)         (54)                                   
      Hyperplasia, Lymphoid                                         2 (5%)       5 (10%)      1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Macrophage                                                                 1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (48)         (44)         (57)                                   
      Congestion                                       5 (8%)       1 (2%)       4 (9%)       1 (2%)                                
      Hemorrhage                                                                              2 (4%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
      Sinus, Dilatation                                                          1 (2%)                                             
   Spleen                                             (59)         (50)         (47)         (58)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Cyst                                                                                    1 (2%)                                
      Developmental Malformation                       2 (3%)       1 (2%)       1 (2%)       6 (10%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            5 (8%)       4 (8%)       4 (9%)       2 (3%)                                
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Inflammation, Pyogranulomatous                                             1 (2%)                                             
   Thymus                                             (51)         (49)         (39)         (56)                                   
      Atrophy                                                       1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)       1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (50)         (49)         (58)                                   
      Alopecia                                         4 (7%)       2 (4%)       3 (6%)       3 (5%)                                
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Parakeratosis                                                              1 (2%)                                             
      Ulcer                                                                                   1 (2%)                                
      Sebaceous Gland, Metaplasia, Squamous                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (51)         (51)         (60)                                   
      Hyperostosis                                     1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
   Skeletal Muscle                                    (1)                                    (2)                                    
      Hemorrhage                                                                              1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (49)         (48)         (60)                                   
      Infiltration Cellular, Lymphocyte                2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (53)         (60)                                   
      Congestion                                       1 (2%)       2 (4%)       2 (4%)                                             
      Edema                                            1 (2%)                                 1 (2%)                                
      Emphysema                                                     1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Macrophage                                       2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)       2 (4%)                                             
      Pigmentation                                                  1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)       4 (8%)                    2 (3%)                                
      Alveolus, Giant Cell                                          1 (2%)                                                          
      Peribronchiolar, Infiltration Cellular,                                                                                       
          Lymphocyte                                                1 (2%)                                                          
   Nose                                               (60)         (51)         (50)         (60)                                   
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       2 (3%)                                
      Nasolacrimal Duct, Hyperplasia, Squamous                                                1 (2%)                                
      Vomeronasal Organ, Inflammation,                                                                                              
          Proliferative                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (2)                                                 
      Pinna, Hyperplasia, Squamous                                               1 (50%)                                            
      Pinna, Inflammation, Suppurative                                           2 (100%)                                           
   Eye                                                (3)          (3)          (2)          (2)                                    
      Cataract                                         1 (33%)      1 (33%)                   1 (50%)                               
      Anterior Chamber, Edema                                                                 1 (50%)                               
      Cornea, Edema                                                                           1 (50%)                               
      Cornea, Inflammation, Chronic                                              1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (51)         (59)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                                                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                6 (10%)      1 (2%)       3 (6%)                                             
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05091-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Metaplasia, Osseous                                                                     1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Necrosis, Coagulative                            1 (2%)                                                                       
      Nephropathy                                     45 (75%)     46 (90%)     45 (88%)     43 (73%)                               
      Cortex, Cyst                                     2 (3%)       1 (2%)       5 (10%)      4 (7%)                                
      Medulla, Mineralization                                                                 1 (2%)                                
      Pelvis, Epithelium, Hyperplasia                                            1 (2%)                                             
      Renal Tubule, Hyperplasia                                     1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia, Cystic                2 (3%)       1 (2%)       4 (8%)       2 (3%)                                
   Urinary Bladder                                    (60)         (47)         (46)         (58)                                   
      Dilatation                                       1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                2 (3%)       4 (9%)       5 (11%)      3 (5%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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