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TDMS Study 05091-02 Pathology Tables

NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97
Route: GAVAGE                                                                                                     Time: 09:13:27




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A     A  +  +     +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Hepatocellular Carcinoma             |                                  X                                      X|             
      Hepatocellular Adenoma               |             X     X  X                                            X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  I  M  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |                      X        X                 X                 X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Cystadenoma                          |                                                                          |             
      Granulosa Cell Tumor Benign          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +        +                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                              X                           |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I     +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                 X                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                  X                                       |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                    +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                    +                                             |             
      Adenoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +     +  +  +  +  A  +     +  A     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +     +  +  +  +  A  +     A  A     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +     +  +  +  +  A  +     A  A     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |    X                                                  X                  |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +     +  +  +  +  A  +     +  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +     +  +  +  +  A        A  A     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +     +  +  +  +  A  +     +  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M     M  M     +  M  M  +  M  +     M  +     +  M  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +     M  +     +  +  +  +  +  M     A  +     +  +  +  +     +  +  +   |             
      Pars Distalis, Adenoma               |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +     +  +  +  +  +  +     A  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Cystadenoma                          |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Sarcoma Stromal                      |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +     +  +  +  +  +  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +     +  +  +  +  M  +     +  +     +  +  +  +     +  +  +   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
      Mediastinal, Lymphoma Malignant Mixed|                                           X                              |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
      Renal, Lymphoma Malignant Mixed      |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +     +  +  +  M  M  +     +  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +     +  +  +  +  A  +     +  +     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Adenoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +     +  +  +  +  +  +     A  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +     +  +  +  +  A  +     +  A     +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  56        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Hepatocellular Carcinoma             |                         X                                                |          3 |
      Hepatocellular Adenoma               |    X        X  X                    X  X  X                              |         12 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                               X                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Squamous Cell Papilloma              | X  X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +     M  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  +  +  +  M     +  +  +  +  +  M  +  +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  56        |
      Pars Distalis, Adenoma               | X  X           X                             X                           |          9 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  57        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Cystadenoma                          |                                           X                              |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  57        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +     +  M  +  +  +  +  +  +  +  +               |  56        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  +  +  +  I     A  +  +  +  M  +  +  +  +  +               |  54        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                         X                                                |          2 |
      Lymphoma Malignant                   |                               X                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  57        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +  +  +     A  A  +  +  +  +  +  +  +  +               |  54        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                               X                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                               X                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|             
                                           | 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hepatocellular Carcinoma             |                                                                   X      |             
      Hepatocellular Adenoma               |                            X  X  X  X           X                        |             
      Hepatocellular Adenoma, Multiple     |                                           X        X     X  X     X      |             
      Lymphoma Malignant Lymphocytic       |          X     X                                                         |             
      Lymphoma Malignant                   |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant                   |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Pheochromocytoma Benign              |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +  +  +     +  +  M  M  +  M  +     +  +     +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +     M  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|             
                                           | 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Follicular Cell, Adenoma             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Cystadenoma                          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +     +|             
      Polyp                                |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |          X                                                               |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |          X                                X                              |             
      Renal, Lymphoma Malignant Lymphocytic|                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant                   |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                X                          X                              |             
      Lymphoma Malignant                   |                                                 X                        |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +  +  +     +  I  +  +  I  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  M  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|             
                                           | 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
      Adenoma                              |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +     +|             
      Lymphoma Malignant                   |                X                                X                        |             
      Lymphoma Malignant Lymphocytic       |          X     X                          X                              |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|             
                                           | 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant                   |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |    X           X                       X        X        X     X         |             
      Hepatocellular Adenoma, Multiple     |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Squamous Cell Papilloma              |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M        +  +  M  +  +        +  +  +  M     +  M     +  +  M     M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|             
                                           | 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                                        X                                X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Cystadenoma                          |                                           X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +  +  +        +  +  +  +     +  +     +  +  +  +  +  +|             
      Polyp                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  I  +     M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +  +  +  M  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|             
                                           | 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X              X|             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Adenoma                              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +        +  +  +  +  +        +  +  +  +     +  +     +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3|              |            |
                                           | 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hepatocellular Carcinoma             |                         X                                                |          2 |
      Hepatocellular Adenoma               |             X                 X           X                              |         14 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          6 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3|              |            |
                                           | 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Adenoma                              |                                           X                              |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  M  I  +     +  +     +  +  +     +        +  +  +               |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  M               |  48        |
      Pars Distalis, Adenoma               |                      X                                X                  |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  51        |
      Cystadenoma                          |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +     +  +     +  +  +  +  +        +  +  +               |  56        |
      Polyp                                |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  48        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          2 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3|              |            |
                                           | 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +     +  M     +  +  +     +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +     +  +     +  +  +  +  +        +  +  +               |  52        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |          X  X                                            X               |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   3        |
      Adenoma                              |             X                                                            |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +  +     +  +     +  +  +  +  +        +  +  +               |  56        |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          4 |
      Lymphoma Malignant Mixed             |                                  X                                       |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|             
                                           | 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  M  A   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  M  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Hepatocellular Carcinoma             |                      X           X                                       |             
      Hepatocellular Adenoma               |    X           X                       X              X     X  X  X      |             
      Hepatocellular Adenoma, Multiple     |       X              X              X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Neoplasm NOS                         |                                                                      X   |             
      Hepatocyte, Hepatocellular Adenoma   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +  +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +  +  A   |             
      Squamous Cell Papilloma              |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  M  M  +     +  +  +  +  M  +  M     +     M  M     +  M  +  A   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Pars Distalis, Adenoma               |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|             
                                           | 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fibroma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  I   |             
      Cystadenoma                          |                               X                                          |             
      Luteoma                              |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +  M  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lumbar, Carcinoma, Metastatic,       |                                                                          |             
          Clitoral Gland                   |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     M  +  +  +     +  M  M  +  +  +  I     M     M  +     +  M  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     +  M  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Osteosarcoma                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|             
                                           | 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
      Adenoma                              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|             
                             DAY ON TEST   | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|             
                                           | 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |             X        X                 X                                 |             
      Hepatocellular Adenoma, Multiple     |    X                                         X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Neoplasm NOS                         |                                                                          |             
      Hepatocyte, Hepatocellular Adenoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  A  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  A  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  A  +  +     +     +     +  +  +  +  +     +              +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +     +     +     +  +  +  +  M     +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +     +     +     +  +  +  +  M     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +     +     +     +  +  +  +  M     +              +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  M  +     M     +     M  I  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Pars Distalis, Adenoma               |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Follicular Cell, Adenoma             |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|             
                             DAY ON TEST   | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|             
                                           | 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fibroma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +              +                                                         |             
      Carcinoma                            |                X                                                         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Cystadenoma                          |                                                                          |             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +     +     +  +  +  +  +  +  +     +  +           +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Lumbar, Carcinoma, Metastatic,       |                                                                          |             
          Clitoral Gland                   |                X                                                         |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  M  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  A  +     +     +     +  +  +  +  +     +              +|             
      Subcutaneous Tissue, Fibrosarcoma    | X                                                                        |             
      Subcutaneous Tissue, Hemangioma      |             X                                                            |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|             
                             DAY ON TEST   | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|             
                                           | 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  A  +     +     +     +  +  +  +  +     +              +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  M                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
      Adenoma                              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  A  +  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +     +     +  +  +  +  +  +  +     +  +           +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|              |            |
                             DAY ON TEST   | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5|              |            |
                                           | 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |     A      |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +     +  +  +  +     +  +  +  +  +  +  A     +  I                  |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  45        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | M     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  53        |
      Hepatocellular Carcinoma             |                            X                          X                  |          4 |
      Hepatocellular Adenoma               | X                    X           X  X                                    |         14 |
      Hepatocellular Adenoma, Multiple     |             X                 X        X           X                     |          9 |
      Lymphoma Malignant Lymphocytic       | X                                            X                           |          2 |
      Neoplasm NOS                         |                                                                          |          1 |
      Hepatocyte, Hepatocellular Adenoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Lymphoma Malignant Lymphocytic       | X                                            X                           |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       | X                                            X                           |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  45        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +     +  +  M  +     +  +  +  +  +  +  +     +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +     +  +  M  +     +  +  +  +  +  +  +     +  +                  |  47        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +     +  +  M  +     +  +  +  +  +  +  +     +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     +     +  +  M  +     +  M  +  M  M  +  +     +  +                  |  33        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|              |            |
                             DAY ON TEST   | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5|              |            |
                                           | 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |     A      |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  47        |
      Pars Distalis, Adenoma               |             X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  49        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                    +                     |   1        |
      Fibroma                              |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  50        |
      Cystadenoma                          |                                                                          |          1 |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  56        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Lumbar, Carcinoma, Metastatic,       |                                                                          |            |
          Clitoral Gland                   |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      | X                                            X                           |          2 |
      Renal, Lymphoma Malignant Lymphocytic| X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +     +  +  +  +     +  +  +  +  M  +  +     +  +                  |  40        |
      Lymphoma Malignant Lymphocytic       | X                                            X                           |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  45        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  49        |
      Lymphoma Malignant Lymphocytic       | X                                            X                           |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +     +  +  +  +     +  I  +  +  +  +  +     +  I                  |  47        |
      Lymphoma Malignant Lymphocytic       | X                                            X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|              |            |
                             DAY ON TEST   | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5|              |            |
                                           | 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |     A      |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       | X                                            X                           |          2 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
      Adenoma                              |                               X                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  47        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  58        |
      Lymphoma Malignant Lymphocytic       | X           X                                X                           |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|             
                                           | 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  M  +  +  +  +  A     +  +  +  +  A  A  +  +  M  M  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  A     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                            X                                             |             
      Hepatocellular Carcinoma             |                                              X                           |             
      Hepatocellular Adenoma               |                                           X                 X        X  X|             
      Hepatocellular Adenoma, Multiple     |                   X                 X                                    |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|             
                                           | 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  M  M     +  +  +  M  M  +  +  M  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Pars Distalis, Adenoma               |    X        X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Follicular Cell, Adenoma  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                             +            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Prefemoral, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M  +  +  +  M  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  I     +  +  +  +  M  A  M  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|             
                                           | 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X     X           X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|             
                                           | 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  A     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                        X                                 |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|             
                                           | 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  I  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  I|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +     M     +  +  A  A  A  +     +     A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                    X         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |       X     X                                X                 X         |             
      Hepatocellular Adenoma               | X  X  X                                   X           X  X     X         |             
      Hepatocellular Adenoma, Multiple     |                X        X  X        X              X                    X|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  A  A  +     +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +     +     +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|             
                                           | 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  I  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  M     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Pars Distalis, Adenoma               | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M     +     +  +  +  +  +  +     +     +  +|             
      Bilateral, Follicular Cell, Adenoma  | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     M     +  +  +  +  +  +     +     +  +|             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     A     +  +  +  A  A  +     +     +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Prefemoral, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +     +     +  +  M  +  +  +     +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +     A     +  +  +  A  A  M     +     +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|             
                                           | 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +     A     +  +  +  +  A  +     +     +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  M  +     +     +  +|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
      Meninges, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|             
                                           | 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Lymphoma Malignant                   |                                           X                    X         |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +     A  A  +  +  +     M  +  +  +  A  +  A  +     +               |  42        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     A  A  +  +  +     +  +  +  +  +  +  A  +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     A  A  M  +  +     +  +  +  +  +  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +     A  A  +  A  +     +  +  +  +  A  +  A  +     +               |  46        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  48        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  61        |
      Hemangiosarcoma                      |                               X                                          |          2 |
      Hepatocellular Carcinoma             |                                           X                              |          6 |
      Hepatocellular Adenoma               |                X                    X                                    |         13 |
      Hepatocellular Adenoma, Multiple     |       X                                                                  |          9 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     A  +  +  +  +     +  +  +  +  +  +  A  +     +               |  56        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     A  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     A  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     A  A  +  A  +     +  +  +  +  +  +  A  +     +               |  50        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  A  +  A  +     +  +  +  +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  A  +  A  +     +  +  +  +  +  +  +  +     +               |  57        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  A  +  A  +     +  +  +  +  +  +  +  +     +               |  57        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     A  +  +  +  +     +  +  +  +  +  +  A  +     +               |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  M  M  +  +     +  M  M  +  +  M  +  +     +               |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  I  +  +  +     M  +  +  +  +  +  +  +     +               |  56        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Pars Distalis, Adenoma               |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  M  +  +     +  +  +  +  +  +  +  +     +               |  58        |
      Bilateral, Follicular Cell, Adenoma  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  59        |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                   +                                                      |   2        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  56        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     M  +  +  +  +     +  +  +  +  +  +  A  +     +               |  57        |
      Iliac, Lymphoma Malignant Lymphocytic|                   X                                                      |          1 |
      Prefemoral, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                   X                                                      |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  I     M  +  +  +  +     M  M  +  +  +  +  M  +     +               |  51        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     M  +  +  +  +     +  +  +  +  +  +  A  M     +               |  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  A  +  +  +     +  +  +  +  +  +  A  +     +               |  55        |
      Hemangiosarcoma                      |                      X                                                   |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                X                     |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  M  +     +               |  59        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                      X                                                   |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  61        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
      Meninges, Lymphoma Malignant         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  A  +     +               |  56        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     M  A  +  +  +     +  +  +  +  +  +  A  +     +               |  54        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  61        |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                X                     |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|             
                                           | 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  A  +  +  +  +     +  I  +  +  +  +  +  +  A  +  I  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Adenocarcinoma                       |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Adenocarcinoma                       | X                                                                        |             
      Adenoma                              |                                                                          |             
      Sarcoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                                                                X         |             
      Hepatocellular Carcinoma             |                   X                                      X               |             
      Hepatocellular Carcinoma, Multiple   |       X                                                                  |             
      Hepatocellular Adenoma               | X     X     X        X        X  X                    X        X         |             
      Hepatocellular Adenoma, Multiple     |    X                                      X                          X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|             
                                           | 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M     +  M  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +     +  +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  M  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  +     +  I  +  +  +  +  +  +  +  I  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M     +  M  +  M  M  M     M  M  M  M  M  M  M  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|             
                                           | 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X           X                 X                       X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                          X               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                       +   |             
      Adenoma                              |                                              X                       X   |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                              +                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|             
                                           | 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  I  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Adenocarcinoma                       |       X                                                                  |             
      Adenoma                              |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hemangiosarcoma                      |                         X                                                |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatocellular Carcinoma             | X        X                             X        X     X                  |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |    X  X  X  X     X     X  X        X     X        X                     |             
      Hepatocellular Adenoma, Multiple     |                      X                 X     X                       X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +  M                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Squamous Cell Carcinoma              |                            X                                             |             
      Squamous Cell Papilloma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic  |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Hemangiosarcoma, Metastatic, Spleen  |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|             
                                           | 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M     +  +  M  +  +  +  M  +  I  +  +  M  +        +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +                          +  +     +  +                       +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Interstitial Cell, Adenoma           |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M        +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Hemangiosarcoma                      |             X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  I  +     +  M  +  I  +  +  +  +  +  +  A  +  I        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M     M  M  +  M  M  M  M  +  M  M  M  M  M        M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|             
                                           | 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                       X  X                           |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                    +                                                |             
      Adenoma                              |    X                    X                                                |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2|              |            |
                                           | 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +  +        +  +     +  +  +  M  +     +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenoma                              |    X                                                                     |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             | X        X                                   X                           |         10 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |    X     X  X                 X           X              X               |         24 |
      Hepatocellular Adenoma, Multiple     |                                                    X                     |          8 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  58        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  58        |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2|              |            |
                                           | 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Spindle Cell, Adenoma                |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     +  +        I  +     M  +  +  +  +     +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  56        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Follicular Cell, Adenoma             |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +              +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +        +  +     M  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | I  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  51        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M     M  M        M  M     +  M  M  M  M     M               |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2|              |            |
                                           | 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          8 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                 +                        |   5        |
      Adenoma                              |                                                 X                        |          5 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|             
                                           | 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +        +  I     +  +        +     +  +     A        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +  +     +  +        +     +  +     A        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +     +  +  +     +     +  +     +  +     +  +  +  +     +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                            X           X  X     X        X  X  X         |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemangioma                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Squamous Cell Carcinoma              |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Squamous Cell Carcinoma, Metastatic  |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +        M  M     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +  +     +  +        +     +  +     +        M  +  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
      Thoracic, Hemangioma                 |                                                                          |             
      Thoracic, Hepatocellular Carcinoma,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|             
                                           | 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
           Metastatic, Liver               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +           +     +                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Bronchial, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic                      |             X                                                            |             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +  +     M  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +     +  +        +     +  +     M        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M        M  M     M  M        M     M  M     M        M  M  M  +     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |          X                       X                             X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|             
                                           | 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                          X               |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                 X                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |             X                                                            |             
      Renal Tubule, Carcinoma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +     +  +  +     +     +  +     +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|             
                                           | 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +     +  +  M     +  +     +  A     +  M  A  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  M  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  A  +        +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +     +  +|             
      Hepatocellular Carcinoma             |                X              X              X        X  X  X            |             
      Hepatocellular Adenoma               | X     X     X     X                                            X     X  X|             
      Hepatocellular Adenoma, Multiple     |          X     X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Hemangioma                           |             X                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  M        +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +     +  +  +     +  +     M  M     +  +  +  +        M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +     +  +     +  M     +  +  +  M        +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +           +            |             
      Thoracic, Hemangioma                 |                                                                          |             
      Thoracic, Hepatocellular Carcinoma,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|             
                                           | 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
           Metastatic, Liver               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +                    +              +              +            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +     +  +  +     +  +     +  M     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Bronchial, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic                      |                                                                          |             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +     +  +     M  M     M  I  M  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +  +  I     +  +     +  +     +  +  +  +        +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M     M  M  M     M  M     M  M     M  M  M  +        M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Alveolar/Bronchiolar Adenoma         | X  X  X                             X                                   X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|             
                                           | 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                    +                                          |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  M  M     +  +  A  I  +        +               |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +               |  56        |
      Hepatocellular Carcinoma             |                X           X           X  X              X               |         11 |
      Hepatocellular Adenoma               |                X  X  X     X                 X     X  X  X               |         22 |
      Hepatocellular Adenoma, Multiple     |             X           X           X                                    |          5 |
      Histiocytic Sarcoma                  |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                             +                     |   3        |
      Hemangioma                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  47        |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  50        |
      Adenoma                              |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +     +  +  +  M  +        +               |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  M     +  +  +  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +  +                           |   5        |
      Thoracic, Hemangioma                 |                                              X                           |          1 |
      Thoracic, Hepatocellular Carcinoma,  |                                                                          |            |
           Metastatic, Liver               |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                                   +                        |  10        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  A  +  +  +  +  A     +  +  I  +  +        +               |  47        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Histiocytic Sarcoma                  |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  M     +  +  +  +  +        +               |  49        |
      Bronchial, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Mediastinal, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  M  +  +  +  M     +  +  +  +  +        +               |  41        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  M     +  +  +  +  +        +               |  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  50        |
      Histiocytic Sarcoma                  |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        I               |  49        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M        M               |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Lung                 |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  52        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |          X                                                               |          1 |
      Alveolar/Bronchiolar Adenoma         | X           X        X  X           X           X                        |         15 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |          2 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                X                          X                              |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Histiocytic Sarcoma                  |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +              +                                                |   3        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +              +                                                |   5        |
      Adenocarcinoma                       |          X                                                               |          1 |
      Adenoma                              |                         X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Hepatocellular Carcinoma, Metastatic |                X                                                         |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X                              |          1 |
      Histiocytic Sarcoma                  |                               X                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +               |  58        |
      Histiocytic Sarcoma                  |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|             
                                           | 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +        +  M     +     +  +     +  +  A  +  +     M   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +  +     +  +|             
      Hepatocellular Carcinoma             |          X     X                                         X               |             
      Hepatocellular Adenoma               |    X              X           X                    X        X  X        X|             
      Hepatocellular Adenoma, Multiple     | X     X     X  X           X              X           X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +        +  +     +     +  A     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
      Squamous Cell Papilloma              |                            X  X                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
      Sarcoma                              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +        M  +     +     +  +     M  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +        +  +     +     +  M     +  +  M  +  +     +   |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                                              +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|             
                                           | 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  A  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Bronchial, Sarcoma                   |          X                                                               |             
      Mediastinal, Sarcoma                 |          X                                                               |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     M   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +        +  +     +     +  M  +  +  +  A  +  +     +   |             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  A  +  +     +   |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +        +  +     +     +  A     +  +  M  +  +     +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  M        M  M     M     M  M     M  M  M  +  M     M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +        +  +     +     +  A     +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |    X                       X  X           X     X           X  X         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                   X      |             
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|             
                                           | 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
      Adenoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
      Renal Tubule, Adenoma                |    X                                                           X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|             
                             DAY ON TEST   | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|             
                                           | 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +     A  +  +  +     +  +  +  +  M     M     +  +     M  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Hepatocellular Carcinoma             |             X                 X              X                 X         |             
      Hepatocellular Adenoma               |       X     X        X     X                 X        X     X            |             
      Hepatocellular Adenoma, Multiple     |                                  X  X  X           X           X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Squamous Cell Papilloma              |                X                                                     X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     M  +  +  +     M  M  +  +  +     +     +  M     +  +  M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +  +  +     +  +  +  M  +     +     +  +     +  +  M  +   |             
      Pars Distalis, Adenoma               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +  +  +     M  +  +  +  +     +     +  +     +  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                            +                                             |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +           +  +                 +              +     +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|             
                             DAY ON TEST   | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|             
                                           | 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     A  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Bronchial, Sarcoma                   |                                                                          |             
      Mediastinal, Sarcoma                 |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Renal, Lymphoma Malignant            |                      X                                                   |             
      Renal, Lymphoma Malignant Mixed      |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     +  +  M  +   |             
      Lymphoma Malignant                   |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Hemangioma                           |                X                                                         |             
      Hemangiosarcoma                      |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     A  I  +  I     +  I  +  +  +     +     +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M     M  M  +  M     M  M  M  M  M     M     M  M     M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         | X     X                             X              X                     |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                            X     X                                       |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|             
                             DAY ON TEST   | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|             
                                           | 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                    +                     |             
      Adenoma                              |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Lymphoma Malignant                   |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1|              |            |
                                           | 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |     A      |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
      Adenocarcinoma                       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +        +  +  +     +     +  +  +  +  +  +  +  +  +  +               |  55        |
      Hepatocellular Carcinoma             |                   X                    X  X     X                        |         11 |
      Hepatocellular Adenoma               |             X     X                       X     X     X                  |         19 |
      Hepatocellular Adenoma, Multiple     | X  X           X              X  X           X     X                     |         19 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +                     |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  46        |
      Squamous Cell Papilloma              |                                                    X                     |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M           +  +     +     +  +  +  +  M  M  +  +  +  M               |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +           +  +     +     +  +  M  +  M  +  +  +  +  +               |  45        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1|              |            |
                                           | 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |     A      |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +                                +  +                  |  13        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Bronchial, Sarcoma                   |                                                                          |          1 |
      Mediastinal, Sarcoma                 |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                  X                                       |          1 |
      Renal, Lymphoma Malignant            |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +           +  +     +     M  +  +  +  A  +  +  +  +  +               |  44        |
      Lymphoma Malignant                   |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  47        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +           +  +     I     +  +  +  I  I  +  I  I  +  +               |  39        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M           M  M     M     M  M  +  M  M  M  M  M  M  M               |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  53        |
      Alveolar/Bronchiolar Adenoma         |                               X                 X                        |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1|              |            |
                                           | 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |     A      |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |    X                                                                     |          4 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  46        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +        +  +  +     +     +  +  +  +  +  +  +  +  +  +               |  56        |
      Lymphoma Malignant                   |                                  X                                       |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|             
                                           | 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +     +  +  +  +  M     M  +  +  +        A  I  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Lymphoma Malignant                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  A        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        A  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             | X                                X                             X         |             
      Hepatocellular Adenoma               | X  X                 X              X        X                 X     X  X|             
      Hepatocellular Adenoma, Multiple     |          X        X        X  X                                          |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  M        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Squamous Cell Carcinoma              |                            X                                             |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  M  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  M        +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +     +  +  M  +  +     +  +  +  +        +  M  +  +|             
      Pars Distalis, Adenoma               |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|             
                                           | 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Liposarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +           +                 +        +                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                  X                                       |             
      Mediastinal,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  M  +  +     +  +  +  +        +  +  +  +|             
      Lymphoma Malignant                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hemangiosarcoma                      |                                                                   X      |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  M  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                  X                                       |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  +     M  M  +  M  M     M  M  M  M        M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|             
                                           | 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                    +                                       |             
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X     X                                X                  |             
      Alveolar/Bronchiolar Carcinoma       |             X                    X                                       |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Liposarcoma, Metastatic, Tissue NOS  |                                                                          |             
      Neoplasm NOS, Metastatic, Liver      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                  X                                       |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Lymphoma Malignant                   |                                                       X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|             
                                           | 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  A  +  A  +     +     +  +  +  +  +  A  +  +  M  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  A  +  +  M  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  A  +  A  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
      Lymphoma Malignant                   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |                                                                X         |             
      Hepatocellular Adenoma               |                   X                    X                 X               |             
      Hepatocellular Adenoma, Multiple     |    X  X     X  X     X           X              X  X                     |             
      Hepatocholangiocarcinoma             |                         X                                                |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   M                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
      Squamous Cell Carcinoma              |             X                                                            |             
      Squamous Cell Papilloma              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  M  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +  +     M     +  +  +  +  M  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|             
                                           | 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Liposarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                +                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  M  +  M  +     +     +  +  +  +  +  +  +  +  +  M  +  I|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +     +     I  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant                   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
      Hemangiosarcoma                      |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  M  +  M  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M  M  M  M  +  M     M     M  M  +  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                                |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|             
                                           | 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X           X                 X     X           X                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                                |             
      Liposarcoma, Metastatic, Tissue NOS  |                                                                          |             
      Neoplasm NOS, Metastatic, Liver      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                             +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                             +                              |             
      Adenoma                              |             X                             X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                                |             
      Lymphoma Malignant                   |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |    X                                                                     |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A     +  +  +  +     +     +  +  M  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A     +  M  +  +     +     +  +  +  +  +  +  +               |  54        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M     +  +  +  +     +     +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  54        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Hepatoblastoma                       |                            X                    X                        |          2 |
      Hepatocellular Carcinoma             |                                  X              X                        |          6 |
      Hepatocellular Adenoma               |       X     X                    X                       X               |         15 |
      Hepatocellular Adenoma, Multiple     |                   X  X  X              X  X     X     X                  |         19 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Lymphoma Malignant                   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Lymphoma Malignant                   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Squamous Cell Papilloma              |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  56        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  78                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     M  +  +  +     +     M  +  +  M  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     M  +  +  +     +     +  +  +  +  +  +  +               |  55        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Follicular Cell, Adenoma             |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   1        |
      Liposarcoma                          |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +     +  +                 +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Lymphoma Malignant                   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Lymphoma Malignant                   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinal,                         |                                                                          |            |
          Hepatocholangiocarcinoma,        |                                                                          |            |
          Metastatic, Liver                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M     +  +  +  +     +     +  +  +  +  +  +  +               |  54        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  57        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Lymphoma Malignant                   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  I     +     +  +  +  +  +  +  +               |  56        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Lymphoma Malignant                   |             X                                                            |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  79                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M     M  M  M  M     M     M  M  M  M  M  M  M               |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Alveolar/Bronchiolar Adenoma         |                      X           X                       X               |         11 |
      Alveolar/Bronchiolar Carcinoma       |                                           X                              |          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Liposarcoma, Metastatic, Tissue NOS  |       X                                                                  |          1 |
      Neoplasm NOS, Metastatic, Liver      |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05091-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/08/97  
Route: GAVAGE                                                                                                     Time: 09:13:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |     A      |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant                   |             X                                                            |          1 |
      Renal Tubule, Carcinoma              |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Lymphoma Malignant                   |             X                                                            |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
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                                  ----------              END OF REPORT             ----------                                      
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