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TDMS Study 05091-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          DIHYDROCOUMARIN


NTP Experiment-Test: 05091-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 13:00:29




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 19           20           19           18                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       2                                                                            
    Moribund                                           5            9            4            5                                     
    Dead                                               8            2            5           18                                     
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           39           41           28                                     
    Dead                                                                                      1                                     
  Animals Examined Microscopically                    60           56           58           61                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (54)         (50)         (44)         (42)                                   
   Intestine Large, Cecum                             (53)         (50)         (46)         (49)                                   
   Intestine Large, Colon                             (54)         (50)         (46)         (49)                                   
   Intestine Small, Duodenum                          (54)         (50)         (46)         (46)                                   
   Intestine Small, Ileum                             (54)         (50)         (45)         (49)                                   
   Intestine Small, Jejunum                           (56)         (50)         (45)         (48)                                   
   Liver                                              (60)         (50)         (53)         (61)                                   
      Hemangiosarcoma                                                                         2 (3%)                                
      Hepatocellular Carcinoma                         3 (5%)       2 (4%)       4 (8%)       6 (10%)                               
      Hepatocellular Adenoma                          12 (20%)     14 (28%)     14 (26%)     13 (21%)                               
      Hepatocellular Adenoma, Multiple                              6 (12%)      9 (17%)      9 (15%)                               
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Neoplasm NOS                                                               1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Hepatocyte, Hepatocellular Adenoma                                         1 (2%)                                             
   Pancreas                                           (59)         (50)         (48)         (56)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Salivary Glands                                    (60)         (50)         (50)         (59)                                   
   Stomach, Forestomach                               (58)         (50)         (48)         (57)                                   
      Squamous Cell Papilloma                          2 (3%)       2 (4%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (53)         (50)         (45)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (50)         (50)         (60)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (58)         (50)         (47)         (57)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Adrenal Gland, Medulla                             (56)         (50)         (47)         (57)                                   
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (50)         (48)         (56)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (56)         (48)         (47)         (56)                                   
      Pars Distalis, Adenoma                           9 (16%)      5 (10%)      3 (6%)       3 (5%)                                
   Thyroid Gland                                      (57)         (50)         (49)         (58)                                   
      Bilateral, Follicular Cell, Adenoma                                                     1 (2%)                                
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)          (1)                                    
      Fibroma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (2)                                                 
      Carcinoma                                                                  1 (50%)                                            
   Ovary                                              (59)         (51)         (50)         (59)                                   
      Cystadenoma                                      1 (2%)       2 (4%)       1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Luteoma                                                                    1 (2%)       1 (2%)                                
   Oviduct                                            (2)                                    (2)                                    
   Uterus                                             (60)         (56)         (56)         (60)                                   
      Polyp                                                         2 (4%)                                                          
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (48)         (56)                                   
   Lymph Node                                         (59)         (50)         (48)         (57)                                   
      Lumbar, Carcinoma, Metastatic, Clitoral Gland                              1 (2%)                                             
   Lymph Node, Mandibular                             (57)         (48)         (40)         (51)                                   
   Lymph Node, Mesenteric                             (56)         (50)         (45)         (49)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (60)         (50)         (49)         (55)                                   
      Hemangiosarcoma                                                                         2 (4%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Thymus                                             (54)         (48)         (47)         (57)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (47)         (48)         (59)                                   
      Adenoma                                          1 (2%)                                                                       
   Skin                                               (60)         (52)         (50)         (60)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (50)         (61)                                   
      Osteosarcoma                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (50)         (47)         (57)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (48)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)       5 (10%)      1 (2%)       3 (5%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (3)          (3)          (1)                                    
      Adenoma                                          1 (50%)      3 (100%)     3 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (50)         (48)         (56)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Ureter                                             (1)                                                                           
   Urinary Bladder                                    (54)         (50)         (47)         (54)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(56)        *(58)        *(61)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant                               1 (2%)       3 (5%)                    3 (5%)                                
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)       4 (7%)       4 (7%)       2 (3%)                                
      Lymphoma Malignant Mixed                         1 (2%)       2 (4%)                    1 (2%)                                
      Lymphoma Malignant Undifferentiated Cell         2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            26          36          38          40                                       
     Total Primary Neoplasms                           40          55          49          50                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 19          29          29          27                                       
     Total Benign Neoplasms                            29          42          37          32                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               9          11          11          16                                       
     Total Malignant Neoplasms                         11          13          11          18                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       3           1                                       
     Total Metastatic Neoplasm                          2                       3           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           19           19           20                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       1            1            1                                                  
    Dead                                               4            8            8            8                                     
    Moribund                                           3            3            8            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           39           34           38                                     
  Animals Examined Microscopically                    60           58           56           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (57)         (46)         (43)         (54)                                   
   Intestine Small, Ileum                             (57)         (46)         (43)         (54)                                   
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
   Intestine Small, Jejunum                           (57)         (45)         (43)         (54)                                   
      Adenocarcinoma                                   2 (4%)                                                                       
      Adenoma                                          1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
   Liver                                              (60)         (56)         (55)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatoblastoma                                                                          2 (3%)                                
      Hepatocellular Carcinoma                        10 (17%)     11 (20%)     11 (20%)      6 (10%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                          24 (40%)     22 (39%)     19 (35%)     15 (25%)                               
      Hepatocellular Adenoma, Multiple                 8 (13%)      5 (9%)      19 (35%)     19 (32%)                               
      Hepatocholangiocarcinoma                                                                1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (3)          (3)          (2)          (1)                                    
      Hemangioma                                                    1 (33%)                                                         
   Pancreas                                           (58)         (50)         (48)         (59)                                   
   Stomach, Forestomach                               (59)         (49)         (46)         (58)                                   
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                    2 (3%)                                
      Squamous Cell Papilloma                          2 (3%)                    5 (11%)      2 (3%)                                
   Stomach, Glandular                                 (58)         (47)         (43)         (56)                                   
      Squamous Cell Carcinoma, Metastatic              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (51)         (51)         (60)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                 1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (50)         (48)         (59)                                   
      Spindle Cell, Adenoma                            1 (2%)                                                                       
   Adrenal Gland, Cortex                              (59)         (50)         (48)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (59)         (49)         (48)         (57)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
   Islets, Pancreatic                                 (59)         (50)         (49)         (60)                                   
      Adenoma                                                       2 (4%)                                                          
   Pituitary Gland                                    (56)         (46)         (45)         (55)                                   
      Pars Distalis, Adenoma                                                     1 (2%)       1 (2%)                                
   Thyroid Gland                                      (59)         (49)         (49)         (60)                                   
      Follicular Cell, Adenoma                         1 (2%)                                 2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (5)                       (1)                                    
      Liposarcoma                                                                             1 (100%)                              
      Thoracic, Hemangioma                                          1 (20%)                                                         
      Thoracic, Hepatocellular Carcinoma,                                                                                           
          Metastatic, Liver                                         1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)         (49)         (48)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)                                                          
   Seminal Vesicle                                    (59)         (48)         (47)         (58)                                   
   Testes                                             (59)         (48)         (48)         (58)                                   
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (51)         (50)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (60)         (49)         (51)         (60)                                   
      Bronchial, Sarcoma                                                         1 (2%)                                             
      Bronchial, Squamous Cell Carcinoma,                                                                                           
          Metastatic                                                1 (2%)                                                          
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (2%)                                
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                                                          
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                                   1 (2%)                                
      Mediastinal, Sarcoma                                                       1 (2%)                                             
   Lymph Node, Mandibular                             (56)         (41)         (49)         (54)                                   
   Lymph Node, Mesenteric                             (59)         (48)         (44)         (57)                                   
   Spleen                                             (59)         (50)         (47)         (58)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                    1 (2%)       2 (3%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (51)         (49)         (39)         (56)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (50)         (49)         (58)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (51)         (51)         (60)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)       1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Skeletal Muscle                                    (1)                                    (2)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (100%)                                                                     
      Diaphragm, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (53)         (60)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     8 (13%)     15 (29%)     13 (25%)     11 (18%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)       4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)       1 (2%)       3 (5%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Liposarcoma, Metastatic, Tissue NOS                                                     1 (2%)                                
      Neoplasm NOS, Metastatic, Liver                                                         1 (2%)                                
   Nose                                               (60)         (51)         (50)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (3)          (2)          (2)                                    
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (33%)                                                         
   Harderian Gland                                    (5)          (5)          (2)          (2)                                    
      Adenocarcinoma                                                1 (20%)                                                         
      Adenoma                                          5 (100%)     4 (80%)      2 (100%)     2 (100%)                              
   Lacrimal Gland                                     (1)          (1)          (1)                                                 
      Adenoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (51)         (59)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma, Metastatic                          1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (2%)                                                          
      Renal Tubule, Adenoma                                                      2 (4%)                                             
                                                             Page  10                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Renal Tubule, Carcinoma                                       1 (2%)                    1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(58)        *(56)        *(60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant                                                         3 (5%)       3 (5%)                                
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
      Lymphoma Malignant Mixed                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05091-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 13:00:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200MG/KG     400MG/KG     800MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          46          48          47                                       
     Total Primary Neoplasms                           72          69          89          75                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          36          43          40                                       
     Total Benign Neoplasms                            52          51          67          53                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          17          16          20                                       
     Total Malignant Neoplasms                         20          18          22          22                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           5           2           5                                       
     Total Metastatic Neoplasm                         11          16           2          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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