TDMS Study 05091-02 Pathology Tables
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
Facility: American Biogenics Corp.
Chemical CAS #: 119-84-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|
| 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + A A + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A A A + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + A + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A A A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A A A + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 1 |
Mixed Cell Focus | 3 |
Necrosis | |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Cyst | |
Central Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 3 3 2 3 1 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A A + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|
| 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 3 |
Valve, Pigmentation, Melanin, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Corticomedullary Junction, Hemorrhage| 3 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | 2 |
Hypertrophy | |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Necrosis | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M I M + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Suppurative | 2 |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Ceroid | 2 3|
Follicle, Cyst | 3 2 3 |
Follicle, Hematocyst | |
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Hyperplasia, Cystic | 2 3 3 4 2 2 3 3 4 2 4 2 4 4 3 2|
Inflammation, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Mononuclear Cell | |
Hyperplasia, Neutrophil | 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|
| 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 3 3 2 2|
Hyperplasia, Macrophage | |
Inflammation, Suppurative | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + I I + + + + + +|
Hyperplasia, Lymphoid | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Lactation | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 1 2 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Hydrocephalus | 2 |
Meninges, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|
| 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Eye | + + |
Cornea, Edema | |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + +|
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | 2 2 2 |
Cortex, Cyst | |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + A + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|
| 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + A + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + A A + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + A A + + + + + + + |
Edema | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + A + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 1 |
Eosinophilic Focus | 2 1 2 3 |
Infiltration Cellular, Lymphocyte | 2 1 2 1 2 |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
Necrosis | 2 3 |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | |
Central Vein, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + |
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 1 2 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + A + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + A + + + + + + + + |
Hyperplasia, Squamous | 2 2 1 2 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A A A + + + + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|
| 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | |
Valve, Pigmentation, Melanin, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + A + + + + + + + + |
Corticomedullary Junction, Hemorrhage| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + A + + + + + + + + |
Congestion | |
Hyperplasia | |
Hypertrophy | |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + M + A + + + + + + + + |
Congestion | |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M M + M M + M + M + + M + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + + M A + + + + + + + + |
Congestion | |
Pars Distalis, Hypertrophy | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + |
Inflammation, Suppurative | |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Pigmentation, Ceroid | |
Follicle, Cyst | 3 3 3 2 2 3 |
Follicle, Hematocyst | 2 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Hydrometra | 4 |
Hyperplasia, Cystic | 3 3 3 4 3 2 2 3 2 4 2 2 4 2 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + |
Hyperplasia, Mononuclear Cell | |
Hyperplasia, Neutrophil | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|
| 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + + + |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + A + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Developmental Malformation | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Macrophage | |
Inflammation, Suppurative | 2 |
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + A + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + |
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Alopecia | 2 1 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + A + A + + + + + + + + |
Compression | |
Hydrocephalus | |
Meninges, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + A + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|
DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|
| 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Eye | |
Cornea, Edema | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + A + + A + + + + + + + |
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | 2 2 3 2 |
Cortex, Cyst | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + A + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2| | |
| 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + + + + + | 54 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + | 54 |
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + | 54 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | | 1 1.0|
Eosinophilic Focus | 2 3 1 | 8 2.1|
Infiltration Cellular, Lymphocyte | 1 1 1 | 9 1.4|
Inflammation, Chronic | | 2 1.5|
Mixed Cell Focus | | 1 3.0|
Necrosis | | 2 2.5|
Vacuolization Cytoplasmic | | 1 3.0|
Bile Duct, Cyst | 2 | 1 2.0|
Central Vein, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Inflammation, Chronic Active | | 1 3.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 59 |
Atrophy | 2 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | 1 1 | 10 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 3 2 1 1 1 1 1 1 1 | 21 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + | 58 |
Hyperplasia, Squamous | 2 2 | 14 2.1|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 12 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2| | |
| 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + A + + + + + + + + + | 59 |
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | | 1 3.0|
Valve, Pigmentation, Melanin, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 58 |
Corticomedullary Junction, Hemorrhage| | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + | 58 |
Congestion | | 1 2.0|
Hyperplasia | | 1 2.0|
Hypertrophy | 3 | 1 3.0|
Pigmentation, Ceroid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + | 56 |
Congestion | | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + + | 46 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 56 |
Congestion | 2 | 1 2.0|
Pars Distalis, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + | 57 |
Inflammation, Suppurative | | 1 2.0|
Follicular Cell, Hyperplasia | 3 1 2 | 5 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + | 59 |
Pigmentation, Ceroid | | 2 2.5|
Follicle, Cyst | 2 3 | 11 2.6|
Follicle, Hematocyst | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Oviduct | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2| | |
| 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + | 60 |
Hydrometra | 4 | 3 3.7|
Hyperplasia, Cystic | 3 2 3 2 3 3 2 2 3 3 2 3 3 3 2 | 46 2.8|
Inflammation, Suppurative | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 59 |
Hyperplasia, Mononuclear Cell | 3 | 1 3.0|
Hyperplasia, Neutrophil | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 59 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 2 | 3 2.3|
Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Macrophage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 60 |
Developmental Malformation | | 2 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 2 3 2 | 12 2.4|
Hyperplasia, Macrophage | 3 | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Capsule, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + I A + + + M + + + + + | 54 |
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + | 60 |
Lactation | 2 | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 60 |
Alopecia | 2 | 7 1.9|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2| | |
| 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 58 |
Compression | | 2 3.0|
Hydrocephalus | | 1 2.0|
Meninges, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 3 2.3|
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + | 3 |
Cornea, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 57 |
Glomerulosclerosis | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 3 2 | 12 2.2|
Cortex, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A A + + + + + + + + | 54 |
Infiltration Cellular, Lymphocyte | 2 1 1 2 2 2 | 17 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|
| 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 3 |
Eosinophilic Focus | 1 2 |
Infiltration Cellular, Lymphocyte | 1 1 1 1|
Mixed Cell Focus | |
Necrosis | 3 3 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + |
Fat, Infiltration Cellular, | |
Lymphocyte | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|
| 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
Mineralization | |
Polyarteritis | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | |
Hypertrophy | 2 |
Pigmentation, Ceroid | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M M + M + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Ceroid | 2 |
Follicle, Cyst | 3 2 3 3 |
Follicle, Hematocyst | 2 2 3 3 2 2 2|
Periovarian Tissue, Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hydrometra | 4 3 |
Hyperplasia, Cystic | 2 3 2 3 2 2 2 2 2 3 3 3 3 3 3 4 3 3 3|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|
| 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 4 |
Hyperplasia, Macrophage | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 3 2 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Thymus | + + + + + + I + + I + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Cerebellum, Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|
| 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 3 2 2|
Necrosis, Coagulative | |
Nephropathy | 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|
| 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Basophilic Focus | 4 2 |
Clear Cell Focus | 2 |
Eosinophilic Focus | 2 2 1 1 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 |
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic | |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + |
Fat, Infiltration Cellular, | |
Lymphocyte | |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 1 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|
| 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 |
Mineralization | |
Polyarteritis | 3 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Hypertrophy | |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + M + M + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Pigmentation, Ceroid | |
Follicle, Cyst | 3 3 2|
Follicle, Hematocyst | 2 2 3 |
Periovarian Tissue, Hemorrhage | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hydrometra | 4 |
Hyperplasia, Cystic | 3 2 3 3 4 3 3 2 2 3 3 2 3 3 3 2 3 2|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + I + M +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|
| 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
Hyperplasia, Lymphoid | 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 3 3 2 2|
Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Alopecia | 1 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Cerebellum, Necrosis, Coagulative | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|
| 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 3 |
Necrosis, Coagulative | 2 2 |
Nephropathy | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3| | |
| 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 2 3 3 | 6 2.7|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 50 |
Basophilic Focus | 3 | 3 3.0|
Clear Cell Focus | | 2 2.5|
Eosinophilic Focus | 2 3 2 1 2 | 11 1.7|
Infiltration Cellular, Lymphocyte | | 8 1.1|
Mixed Cell Focus | 4 3 | 2 3.5|
Necrosis | | 2 3.0|
Vacuolization Cytoplasmic | | 1 2.0|
Bile Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 | 13 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 3 1 1 | 20 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 50 |
Hyperplasia, Squamous | 2 | 6 1.8|
Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3| | |
| 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 | 3 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Mineralization | 2 3 | 2 2.5|
Polyarteritis | | 2 2.5|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 50 |
Cyst | | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Hypertrophy | | 1 2.0|
Pigmentation, Ceroid | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M I + + + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M | 48 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 50 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 51 |
Pigmentation, Ceroid | | 1 2.0|
Follicle, Cyst | 4 2 4 | 10 2.9|
Follicle, Hematocyst | 2 3 | 12 2.3|
Periovarian Tissue, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 56 |
Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3| | |
| 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | | 3 3.7|
Hyperplasia, Cystic | 3 3 3 4 2 1 3 4 2 3 2 3 3 2 4 | 52 2.7|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 50 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 50 |
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 48 |
Congestion | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 3 3 | 6 3.2|
Hyperplasia, Macrophage | 3 | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 50 |
Developmental Malformation | X X | 3 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 3 2 2 | 12 2.4|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + | 48 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + + + + | 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 52 |
Alopecia | 3 | 2 2.0|
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic | | 1 3.0|
Osteopetrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3| | |
| 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hydrocephalus | | 1 3.0|
Cerebellum, Necrosis, Coagulative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 3 | 7 2.4|
Necrosis, Coagulative | | 2 2.0|
Nephropathy | 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 3 2 2 1 1 2 1 | 22 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|
| 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M A |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 4 |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | 1 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Suppurative | 1 1 |
Mixed Cell Focus | 2 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A |
Atrophy | |
Infiltration Cellular, Lymphocyte | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 2 2 2 |
Inflammation, Chronic Active | 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A |
Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|
| 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + A |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + M + M + M M + M + A |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A |
Infiltration Cellular, Lymphocyte | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + I |
Follicle, Cyst | 3 3 4 3 |
Follicle, Hematocyst | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + A |
Hydrometra | 4 |
Hyperplasia, Cystic | 3 2 3 3 3 3 3 2 3 3 2 1 4 2 3 2 3 2 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A |
Hyperplasia, Erythrocyte | |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + A |
Mediastinal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + M M + + + I M M + + M + A |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + A |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A |
Hematopoietic Cell Proliferation | |
Hyperplasia, Erythrocyte | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + A |
Atrophy | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + A |
Alopecia | 3 1 |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|
| 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
Necrosis | |
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Spinal Cord | + |
Degeneration | 3 |
Demyelination | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + A |
Congestion | 1 |
Hyperplasia, Macrophage | 1 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + A |
Glomerulosclerosis | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Metaplasia, Cartilagenous | |
Necrosis, Coagulative | 2 2 |
Nephropathy | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A |
Dilatation | 4 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 2 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|
DAY ON TEST | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|
| 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
400MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A A + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Autolysis | |
Basophilic Focus | |
Clear Cell Focus | 2 2 |
Eosinophilic Focus | 2 3 1 2 2 |
Infiltration Cellular, Lymphocyte | 3 3 1 2|
Inflammation, Suppurative | |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + +|
Atrophy | 4 |
Infiltration Cellular, Lymphocyte | 1 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 3 2 2 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A A + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + M + +|
Hypertrophy | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|
DAY ON TEST | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|
| 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
400MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + M I + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 2|
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 3 2 |
Follicle, Hematocyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Hyperplasia, Cystic | 1 2 3 2 4 4 2 2 2 2 3 2 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Hyperplasia, Erythrocyte | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A A + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Erythrocyte | 3 |
Hyperplasia, Lymphoid | 3 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + A + + + + + + + + + +|
Alopecia | 2 |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|
DAY ON TEST | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|
| 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
400MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Necrosis | 2 |
Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + A + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + +|
Glomerulosclerosis | 4 |
Infiltration Cellular, Lymphocyte | 2 2 2 |
Metaplasia, Cartilagenous | |
Necrosis, Coagulative | 2 |
Nephropathy | 2|
__________________________________________________________________________|
Urinary Bladder | + + + + A A + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| | |
DAY ON TEST | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5| | |
| 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + A + I | 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + | 46 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + + + + + + + + + + A + + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 53 |
Autolysis | | 1 4.0|
Basophilic Focus | 2 | 1 2.0|
Clear Cell Focus | | 2 2.0|
Eosinophilic Focus | 2 3 | 9 2.1|
Infiltration Cellular, Lymphocyte | 1 1 3 | 8 2.0|
Inflammation, Suppurative | | 2 1.0|
Mixed Cell Focus | 2 | 2 2.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 4.0|
Infiltration Cellular, Lymphocyte | 1 1 2 1 | 10 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 3 2 2 1 1 1 1 | 23 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + A + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + A + + | 48 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | 3 | 9 2.2|
Inflammation, Chronic Active | | 2 2.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + A + + | 45 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| | |
DAY ON TEST | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5| | |
| 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + | 47 |
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + | 47 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + A + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + M + M M + + + + | 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | | 2 2.5|
Follicle, Cyst | 2 | 2 2.0|
Follicular Cell, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + | 50 |
Follicle, Cyst | 3 3 4 | 10 3.0|
Follicle, Hematocyst | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 56 |
Hydrometra | 4 4 3 | 5 3.6|
Hyperplasia, Cystic | 2 3 2 3 3 3 2 2 2 2 2 3 3 | 47 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + A + + | 48 |
Hyperplasia, Erythrocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 48 |
Mediastinal, Hyperplasia, Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + | 40 |
Hyperplasia, Lymphoid | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + | 45 |
Hyperplasia, Lymphoid | 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Erythrocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| | |
DAY ON TEST | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5| | |
| 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 | 6 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + I + + + + + + I | 47 |
Atrophy | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 50 |
Alopecia | 2 2 | 5 2.0|
Hyperplasia, Squamous | 2 | 1 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
Necrosis | | 1 2.0|
Osteopetrosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Degeneration | | 1 3.0|
Demyelination | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 48 |
Congestion | | 1 1.0|
Hyperplasia, Macrophage | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| | |
DAY ON TEST | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5| | |
| 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 48 |
Glomerulosclerosis | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 2 2 | 10 2.0|
Metaplasia, Cartilagenous | 2 | 1 2.0|
Necrosis, Coagulative | | 3 2.0|
Nephropathy | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 47 |
Dilatation | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 1 1 1 2 1 | 19 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|
| 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + A + + + + A A + + M M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | 2 4 3 |
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Suppurative | 2 |
Mixed Cell Focus | |
Necrosis | 2 |
Perivascular, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 2 4 |
Infiltration Cellular, Lymphocyte | 1 2 2 1 1 1 |
Inflammation, Suppurative | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + A + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 3 1 1 2 1 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Squamous | 3 2 2 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + A + + + + + + + + + + +|
Cardiomyopathy | |
Infiltration Cellular, Lymphocyte | 1 |
Mineralization | |
Necrosis | |
Atrioventricular Valve, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|
| 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + + M M + + M + + + + + M + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + A A + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fat, Pelvic, Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + +|
Pigmentation, Ceroid | 3 |
Follicle, Cyst | 4 3 |
Follicle, Hematocyst | 2 3 3 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | 2 |
Hydrometra | 4 3 4 |
Hyperplasia, Cystic | 3 2 3 2 2 2 4 2 2 3 2 2 2 2 2 4 3 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A A + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + + + A + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + I + + + + M A M + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|
| 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + +|
Lactation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + A + + + + + + + + + + +|
Alopecia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + A + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + A A + + + + + + + + + +|
Fatty Change | 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 3 2 |
Metaplasia, Cartilagenous | 1 |
Necrosis, Coagulative | |
Nephropathy | 1 2 1 |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 2 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|
| 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
800MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + A + + A A A + + A I|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + A + + A A A + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + M + + A A A + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + A + + A A A + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + A + + A A A + + A +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + A + + A A A + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + A + + A A A + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + A A A + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + A A A + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Eosinophilic Focus | 3 3 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
Mixed Cell Focus | |
Necrosis | 3 |
Perivascular, Fibrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A A + + + +|
Atrophy | 4 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 |
Inflammation, Suppurative | |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Squamous | 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + A + + A A A + + A +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Infiltration Cellular, Lymphocyte | |
Mineralization | 3 |
Necrosis | |
Atrioventricular Valve, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|
| 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
800MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + I + + + + + + + + + + + A + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fat, Pelvic, Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + +|
Pigmentation, Ceroid | |
Follicle, Cyst | 3 3 3 2|
Follicle, Hematocyst | 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hydrometra | 4 4 |
Hyperplasia, Cystic | 2 3 4 3 3 3 3 3 2 3 3 2 4 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + A A + + + +|
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + A + + + A A M + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + A + + + + A + + + +|
Congestion | |
Developmental Malformation | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + M + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|
| 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
800MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + A + + + + + + + + + + + + A + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + +|
Fatty Change | |
Infarct | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Metaplasia, Cartilagenous | |
Necrosis, Coagulative | |
Nephropathy | 1 2 |
Cortex, Cyst | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + A + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7| | |
DAY ON TEST | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3| | |
| 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + A + A A + + + M + + + A + A + + | 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + A A + + + + + + + + + A + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + + + + + + + A + A + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A A + + + + + + + A + A + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A A M + + + + + + + + A + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + A A + + + + + + + A + A + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A A + A + + + + + A + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A A + + + + + + + A + A + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A A + + + + + + + A + A + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 61 |
Basophilic Focus | | 1 3.0|
Eosinophilic Focus | 3 2 | 8 2.8|
Infiltration Cellular, Lymphocyte | 1 4 1 | 5 1.8|
Inflammation, Suppurative | | 1 2.0|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis | 4 | 3 3.0|
Perivascular, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + A + + | 56 |
Atrophy | | 3 3.3|
Infiltration Cellular, Lymphocyte | 2 1 | 12 1.3|
Inflammation, Suppurative | 2 | 1 2.0|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 | 23 1.5|
__________________________________________________________________________|____________|
Stomach | + + + A A + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A A + + + + + + + + + + + + | 57 |
Hyperplasia, Squamous | 2 | 6 2.2|
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A A + A + + + + + + + A + + | 50 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 4 1.0|
Mineralization | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7| | |
DAY ON TEST | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3| | |
| 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Necrosis | 2 | 1 2.0|
Atrioventricular Valve, Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + A + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + A + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + A + A + + + + + + + + + + | 57 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + A + + | 56 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + M M + + M + + + | 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + + + M + + + + + + + + | 56 |
Pars Distalis, Cyst | 3 | 2 2.5|
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
Follicular Cell, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Fat, Pelvic, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + | 59 |
Pigmentation, Ceroid | | 1 3.0|
Follicle, Cyst | 4 3 4 | 9 3.2|
Follicle, Hematocyst | 3 | 5 2.6|
__________________________________________________________________________|____________|
Oviduct | + | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hydrometra | 2 | 6 3.5|
Hyperplasia, Cystic | 3 1 1 2 3 3 2 2 1 3 2 3 | 47 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + + + + + A + + | 57 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + I M + + + + M M + + + + M + + | 51 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7| | |
DAY ON TEST | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3| | |
| 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + A M + | 49 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + A + + | 55 |
Congestion | | 1 3.0|
Developmental Malformation | | 1 |
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Hyperplasia, Lymphoid | 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + A + + + + + + + + + + + + | 57 |
Atrophy | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + M + + | 59 |
Lactation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 60 |
Alopecia | 3 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 61 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + A + + + + + + + + + + + + | 57 |
Compression | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A + + | 56 |
Fatty Change | | 1 2.0|
Infarct | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7| | |
DAY ON TEST | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3| | |
| 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 | 9 1.9|
Metaplasia, Cartilagenous | | 1 1.0|
Necrosis, Coagulative | 2 | 1 2.0|
Nephropathy | | 5 1.4|
Cortex, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M A + + + + + + + + + A + + | 54 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 | 19 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|
| 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + A + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + I + + + + + + A + I +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | 2 4 3 |
Fatty Change | 2|
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 1 |
Mixed Cell Focus | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | +|
Fat, Inflammation, Suppurative | |
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Cyst | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Squamous | 2 2 3 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|
| 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Suppurative | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + M M|
Pars Distalis, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|
| 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + + + + + + I + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M + M M M M M M M M M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Hyperkeratosis | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + A + + +|
Infiltration Cellular, Lymphocyte | 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 1 |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | 3 |
Necrosis, Coagulative | |
Nephropathy | 1 1 2 1 2 1 1 1 1 1 4 1 1 1 1 1 |
Cortex, Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|
| 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|
| 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + I +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 |
Clear Cell Focus | 2 2 |
Eosinophilic Focus | 2 3 2 |
Fatty Change | 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + M |
Fat, Inflammation, Suppurative | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + +|
Atrophy | 3 4 |
Cyst | 4 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 3 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + + + + + +|
Serosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperplasia, Squamous | 2 2 2 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|
| 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M + + + M + I + + M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + A + + + + + +|
Granuloma Sperm | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + A + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + A + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|
| 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Developmental Malformation | X |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | I + + I + + M + I + + + + + + A + I + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M + M M M M + M M M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + A + + + + + +|
Alopecia | 1 |
Hyperkeratosis | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + A + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Infiltration Cellular, Lymphocyte | 3 1 2|
Necrosis, Coagulative | 2 |
Nephropathy | 2 1 2 1 1 2 1 1 1 1 2 2 1 2 2 1 1 |
Cortex, Cyst | 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|
| 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
VEHICLE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2| | |
| 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 3 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 54 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Basophilic Focus | 2 2 | 3 1.7|
Clear Cell Focus | 1 | 3 1.7|
Eosinophilic Focus | 2 2 2 | 9 2.4|
Fatty Change | | 2 2.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Mixed Cell Focus | | 1 2.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Suppurative | | 1 2.0|
Fat, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 58 |
Atrophy | | 4 2.5|
Cyst | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 1 1 1 | 21 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 59 |
Serosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | | 1 |
Hyperplasia, Squamous | 3 2 2 | 10 2.2|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2| | |
| 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy | 2 | 2 2.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 60 |
Capsule, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 59 |
Hyperplasia | 2 | 3 1.7|
Hypertrophy | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 59 |
Hyperplasia | 3 | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + I + M + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 56 |
Pars Distalis, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 59 |
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 59 |
Granuloma Sperm | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 12 |
Inflammation, Suppurative | 3 | 1 3.0|
Duct, Dilatation | 4 | 11 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 59 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2| | |
| 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + | 59 |
Congestion | 2 | 5 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Developmental Malformation | X | 2 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 5 2.4|
__________________________________________________________________________|____________|
Thymus | I + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M M M | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 59 |
Alopecia | 2 3 | 4 2.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 60 |
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 60 |
Congestion | 1 | 1 1.0|
Edema | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2| | |
| 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | A |
VEHICLE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
CONTROL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 60 |
Hydronephrosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 | 6 2.2|
Necrosis, Coagulative | | 1 2.0|
Nephropathy | 2 1 1 1 1 1 1 1 2 1 1 1 | 45 1.3|
Cortex, Cyst | | 2 1.5|
Renal Tubule, Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|
| 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + I + + + + + A + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 |
Basophilic Focus | |
Clear Cell Focus | 2 3 |
Eosinophilic Focus | 2 3 2 |
Fatty Change | 2 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
Mixed Cell Focus | |
Necrosis | 3 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | 4 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 3 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|
| 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Atrium, Thrombosis | 4 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + M M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Follicle, Degeneration | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | |
Necrosis | 4 |
Abdominal, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Atrophy | |
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|
| 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + +|
Congestion | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Alopecia | 2 3 |
Cyst Epithelial Inclusion | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Emphysema | 3 |
Hyperplasia, Macrophage | 3 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Giant Cell | |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|
| 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
Nephropathy | 1 1 1 1 1 2 1 2 1 1 1 1 1 1|
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia, Cystic | 1 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|
| 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + A + M A + +|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + A + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + A A + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 |
Clear Cell Focus | 2 2 |
Eosinophilic Focus | 3 |
Fatty Change | |
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Suppurative | 4 2 |
Mixed Cell Focus | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Infiltration Cellular, Lymphocyte | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + +|
Hyperplasia, Squamous | 2 2 |
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + +|
Cyst | 2 |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|
| 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 |
Atrium, Thrombosis | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 3 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + M M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + +|
Follicle, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Hemorrhage | 4 |
Necrosis | |
Abdominal, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic | 3 |
Mineralization | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 3 3 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + A + + + + +|
Atrophy | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|
| 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M M M I M + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + I + + + + + + + + +|
Atrophy | 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Cyst Epithelial Inclusion | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Emphysema | |
Hyperplasia, Macrophage | |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 4 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 3 2 2|
Alveolus, Giant Cell | 3 |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|
| 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
200MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Suppurative | 4 |
Nephropathy | 2 1 1 1 1 1 1 1 1 2 1 1 2 2 2 1 1|
Cortex, Cyst | |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7| | |
DAY ON TEST | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2| | |
| 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + M M + + A I + + | 40 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + A + + A + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + A + + A + + + | 46 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + A + + A + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + A + + A + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + A + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + A + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + A + + A + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + A + + A + + + | 45 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 56 |
Angiectasis | | 4 2.8|
Basophilic Focus | | 1 2.0|
Clear Cell Focus | 1 3 1 | 7 2.0|
Eosinophilic Focus | 3 2 3 1 | 8 2.4|
Fatty Change | | 2 2.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Suppurative | | 2 3.0|
Mixed Cell Focus | 2 | 2 2.0|
Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + + + + + + | 50 |
Atrophy | 2 | 2 3.0|
Cyst | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + A + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 1 1 1 | 23 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + A + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + | 49 |
Hyperplasia, Squamous | 2 2 3 | 8 2.1|
Inflammation, Suppurative | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + A + + A + + + | 47 |
Cyst | | 1 2.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7| | |
DAY ON TEST | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2| | |
| 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Atrium, Thrombosis | | 1 4.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + A + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + | 50 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 2 | 7 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + | 49 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + M + + + + + + | 46 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + | 49 |
Follicle, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 5 |
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
Abdominal, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + A + + + + + + | 49 |
Inflammation, Chronic | | 1 3.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 10 |
Inflammation, Suppurative | 3 | 3 3.0|
Duct, Dilatation | 3 | 7 3.4|
__________________________________________________________________________|____________|
Prostate | + + + + + A + + + + A + + I + + + | 47 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7| | |
DAY ON TEST | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2| | |
| 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + A + + + + + + | 48 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + A + + + + A + + + + + + | 48 |
Atrophy | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 51 |
Hyperplasia, Neutrophil | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + M + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M M + + + M + + + + + + | 41 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + M + + + + + + | 48 |
Congestion | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + | 50 |
Developmental Malformation | X | 1 |
Hyperplasia, Lymphoid | 2 3 2 | 4 2.3|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + I | 49 |
Atrophy | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + A + + + + A + + + + + + | 50 |
Alopecia | | 2 2.5|
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 51 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + A + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + A + + + + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7| | |
DAY ON TEST | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2| | |
| 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
200MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | 1 | 2 1.0|
Emphysema | | 1 3.0|
Hyperplasia, Macrophage | | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Pigmentation | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 2.5|
Alveolus, Giant Cell | | 1 3.0|
Peribronchiolar, Infiltration | | |
Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 51 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 51 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Nephropathy | 1 1 2 1 2 1 1 1 1 1 1 2 1 1 2 | 46 1.2|
Cortex, Cyst | | 1 2.0|
Renal Tubule, Hyperplasia, Cystic | | 1 1.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + A + + A + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|
| 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + A + + M |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + A + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + A + + A + + + |
Hyperplasia, Lymphoid | 3 3 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + A + + A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + A + + A + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + A + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + A + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | 2 2 2 2 3 1 2 2 |
Eosinophilic Focus | 2 2 2 1 3 3 2 |
Fatty Change | 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Mixed Cell Focus | 2 |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + |
Atrophy | |
Inflammation, Chronic | |
Polyarteritis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 2 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + A + + A + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + A + + + |
Hyperplasia, Squamous | 2 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + A + + A + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 3 2 |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|
| 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + A + + + |
Hypertrophy | |
Infarct | |
Pigmentation, Ceroid | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + A + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + + + M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + M + + + |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + A + + + |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic | |
Duct, Dilatation | 2 3 |
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + A + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + A + + + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + A + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + M + + + A + + + |
Congestion | |
Sinus, Dilatation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|
| 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Developmental Malformation | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | |
Inflammation, Pyogranulomatous | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + A + + M + + + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M + M M |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + A + + + |
Alopecia | 3 |
Fibrosis | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Parakeratosis | |
Sebaceous Gland, Metaplasia, Squamous| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + A + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hemorrhage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + M + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
Vomeronasal Organ, Inflammation, | |
Proliferative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Hyperplasia, Squamous | |
Pinna, Inflammation, Suppurative | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|
DAY ON TEST | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|
| 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 1 |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Suppurative | |
Nephropathy | 1 1 1 3 1 1 1 1 1 1 1 1 1 4 2 1 1 |
Cortex, Cyst | 1 |
Pelvis, Epithelium, Hyperplasia | 3 |
Renal Tubule, Hyperplasia, Cystic | 1 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + |
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|
DAY ON TEST | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|
| 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
400MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + M M + + M + A + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + A + A + |
Hyperplasia, Lymphoid | 3 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + A + |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + A + A + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + A + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + A + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + A + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + A + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 2 |
Clear Cell Focus | 2 1 2 2 3 |
Eosinophilic Focus | 1 2 |
Fatty Change | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + |
Atrophy | 2 3 |
Inflammation, Chronic | |
Polyarteritis | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + A + |
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 1 1 1 1 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + A + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + A + |
Hyperplasia, Squamous | 2 1 3 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + A + A + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 2 2 |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|
DAY ON TEST | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|
| 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
400MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + |
Hypertrophy | 2 |
Infarct | |
Pigmentation, Ceroid | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M M + + + + + M + + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + M + |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + A + |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + A + A + |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Inflammation, Chronic | 2 |
Duct, Dilatation | 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + A + + + + + + + + + + + + + A + |
Dilatation | |
__________________________________________________________________________|
Testes | + + A + + + + + + + + + + + A + + + |
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + M + |
Congestion | 2 2 2 3 |
Sinus, Dilatation | 4 |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + A + A + |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|
DAY ON TEST | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|
| 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
400MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Developmental Malformation | X |
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
Inflammation, Pyogranulomatous | |
__________________________________________________________________________|
Thymus | + + A I + I + I + + + + + + + + + + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Alopecia | |
Fibrosis | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 |
Parakeratosis | |
Sebaceous Gland, Metaplasia, Squamous| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + A + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hemorrhage | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
Vomeronasal Organ, Inflammation, | |
Proliferative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Hyperplasia, Squamous | 3 |
Pinna, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|
DAY ON TEST | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|
| 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
400MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Infarct | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
Nephropathy | 2 1 1 1 1 1 1 1 3 2 2 1 1 1 1 1 |
Cortex, Cyst | 1 1 |
Pelvis, Epithelium, Hyperplasia | |
Renal Tubule, Hyperplasia, Cystic | 1 1 |
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + A + A + |
Infiltration Cellular, Lymphocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1| | |
| 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + A + + + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + A + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + A + + + + + | 43 |
Hyperplasia, Lymphoid | 3 3 3 | 8 2.9|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + A + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + A + + + + + | 43 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + A + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + A + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + A + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + | 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 55 |
Basophilic Focus | 4 2 | 5 2.4|
Clear Cell Focus | 2 | 14 2.0|
Eosinophilic Focus | 2 3 3 4 | 13 2.3|
Fatty Change | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mixed Cell Focus | | 1 2.0|
Necrosis | 2 4 | 3 3.3|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Inflammation, Chronic Active | 4 | 2 3.5|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + | 48 |
Atrophy | | 2 2.5|
Inflammation, Chronic | 4 | 1 4.0|
Polyarteritis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 | 18 1.3|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | A + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + + + + + + + + | 46 |
Hyperplasia, Squamous | 3 2 | 9 2.2|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + A + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1| | |
| 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 51 |
Cardiomyopathy | | 5 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | A + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | A + + + + + + + + + + + + + + | 48 |
Hypertrophy | | 1 2.0|
Infarct | 3 | 1 3.0|
Pigmentation, Ceroid | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | A + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + M M + + + M | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + M + + + + + | 45 |
Pars Distalis, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 49 |
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 13 |
Inflammation, Chronic | | 1 2.0|
Duct, Dilatation | 3 3 2 3 | 13 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + A + + + + + | 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A + + + + + | 47 |
Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 48 |
Atrophy | 3 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1| | |
| 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | A + + + + + + + + + + + + + + | 51 |
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | 3 4 | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + M + + + A + + + + + | 44 |
Congestion | | 4 2.3|
Sinus, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + | 47 |
Congestion | 3 | 1 3.0|
Developmental Malformation | | 1 |
Hyperplasia, Lymphoid | 2 3 | 4 2.5|
Inflammation, Suppurative | 3 | 1 3.0|
Inflammation, Pyogranulomatous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + I + + + I I + I I + + | 39 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 49 |
Alopecia | 1 3 | 3 2.3|
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Parakeratosis | 2 | 1 2.0|
Sebaceous Gland, Metaplasia, Squamous| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + A + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 53 |
Congestion | | 2 2.0|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1| | |
| 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
400MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 1 3.0|
Vomeronasal Organ, Inflammation, | | |
Proliferative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Pinna, Hyperplasia, Squamous | | 1 3.0|
Pinna, Inflammation, Suppurative | 3 | 2 2.5|
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 51 |
Amyloid Deposition | | 1 1.0|
Infarct | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 3 | 3 2.3|
Inflammation, Suppurative | 2 | 1 2.0|
Nephropathy | 2 1 1 1 1 1 1 3 1 2 3 2 | 45 1.4|
Cortex, Cyst | 1 2 | 5 1.2|
Pelvis, Epithelium, Hyperplasia | | 1 3.0|
Renal Tubule, Hyperplasia, Cystic | 1 | 4 1.0|
Renal Tubule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + | 46 |
Infiltration Cellular, Lymphocyte | 2 | 5 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|
DAY ON TEST | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|
| 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + M M + + + A I + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2|
Clear Cell Focus | 2 |
Eosinophilic Focus | 1 2 1 2|
Fatty Change | |
Hemorrhage | |
Inflammation, Suppurative | |
Mixed Cell Focus | 2 3 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 2 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|
DAY ON TEST | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|
| 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | 2 |
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + M + + + + + + + M + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 3 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Developmental Malformation | X X |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|
DAY ON TEST | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|
| 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M + M M + M M M M M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation, Suppurative | 4 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Hyperplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Anterior Chamber, Edema | |
Cornea, Edema | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Suppurative | |
Metaplasia, Osseous | 1 |
Mineralization | |
Nephropathy | 1 1 1 1 2 1 1 1 2 2 1 1 3 1 1|
Cortex, Cyst | 1 |
Medulla, Mineralization | |
Renal Tubule, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|
DAY ON TEST | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|
| 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|
| 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
800MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + A + + + + + + + A + + M + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + A + + A + A +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + M + A +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + A + + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + A + + A + A +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | 2 2 |
Eosinophilic Focus | 2 2 3 2 2 1 2 |
Fatty Change | 1 2 |
Hemorrhage | |
Inflammation, Suppurative | 2 |
Mixed Cell Focus | |
Necrosis | 1|
__________________________________________________________________________|
Mesentery | M |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 3 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + A +|
Hyperkeratosis | 2 3 |
Hyperplasia, Squamous | 3 3 3 3 1 2|
Inflammation, Suppurative | 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + A + + + + A +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|
| 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
800MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | |
Hyperplasia | |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + M + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + A +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Duct, Dilatation | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + A + A +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + M + + + + + + + + + + + M + I|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + M +|
Congestion | 3 |
Hemorrhage | 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + A +|
Cyst | 2 |
Developmental Malformation | X X X |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + M +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|
| 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
800MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M + M M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + A + + +|
Alopecia | |
Inflammation, Suppurative | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Hyperplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Anterior Chamber, Edema | 3 |
Cornea, Edema | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + A +|
Infarct | 2 |
Inflammation, Suppurative | 3 |
Metaplasia, Osseous | |
Mineralization | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | 2 |
Medulla, Mineralization | 2 |
Renal Tubule, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + A +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|
| 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
800MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2| | |
| 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + M + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + M + + + + + + + + + + | 54 |
Hyperplasia, Lymphoid | | 3 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + | 54 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | | 4 2.0|
Clear Cell Focus | 1 3 2 2 | 7 2.0|
Eosinophilic Focus | 2 | 12 1.8|
Fatty Change | 2 | 3 1.7|
Hemorrhage | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Mixed Cell Focus | | 2 2.5|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | 1 1 | 15 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 58 |
Hyperkeratosis | | 2 2.5|
Hyperplasia, Squamous | 2 2 3 2 3 1 3 4 | 16 2.4|
Inflammation, Suppurative | 2 | 6 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2| | |
| 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + A + + + + + + + + + + + + | 57 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + M + + M + + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + | 55 |
Pars Distalis, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 11 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Duct, Dilatation | 3 3 4 3 | 9 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + | 58 |
Atrophy | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 59 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2| | |
| 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Macrophage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 57 |
Congestion | | 1 3.0|
Hemorrhage | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 58 |
Cyst | | 1 2.0|
Developmental Malformation | X | 6 |
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + I + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + A + + + + + + + + + + + + | 58 |
Alopecia | 1 2 | 3 1.7|
Inflammation, Suppurative | | 2 3.5|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 2 2.0|
Nasolacrimal Duct, Hyperplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05091-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 11:27:15
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2| | |
| 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
800MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Anterior Chamber, Edema | | 1 3.0|
Cornea, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 59 |
Infarct | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Metaplasia, Osseous | | 1 1.0|
Mineralization | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.1|
Cortex, Cyst | 2 2 | 4 1.8|
Medulla, Mineralization | | 1 2.0|
Renal Tubule, Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | | 3 1.3|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
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