Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1395

TDMS Study 05091-02 Pathology Tables

NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97
Route: GAVAGE                                                                                                     Time: 11:27:15




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A     A  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     A  +  +     +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     A  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                               3                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                      2   |             
      Inflammation, Chronic                |       1                                                                  |             
      Mixed Cell Focus                     |             3                                                            |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                 3                        |             
      Bile Duct, Cyst                      |                                                                          |             
      Central Vein, Dilatation             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                     2                    2           2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |             1  2     1        1        2                             2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Hyperplasia, Squamous                |    2  3           3  3  2                 3           1                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |       2           2  2  2                 2              2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A     +  +  +     +  +  +|             
      Mineralization                       |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                              3                           |             
      Valve, Pigmentation, Melanin,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Corticomedullary Junction, Hemorrhage|                                  3                       2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Congestion                           |                                                 2                        |             
      Hyperplasia                          |             2                                                            |             
      Hypertrophy                          |                                                                          |             
      Pigmentation, Ceroid                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Congestion                           |                                                                         3|             
      Necrosis                             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  I  M  +  +  +  +     +  +  +     +  +  +|             
      Hyperplasia                          |                                                             3            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Pars Distalis, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  +     +  +  +|             
      Inflammation, Suppurative            |                                                          2               |             
      Follicular Cell, Hyperplasia         |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Pigmentation, Ceroid                 |                                     2                                   3|             
      Follicle, Cyst                       |                         3                                   2        3   |             
      Follicle, Hematocyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +        +                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Hydrometra                           |                3                                                         |             
      Hyperplasia, Cystic                  |    2              3  3  4  2  2  3     3  4     2     4  2  4     4  3  2|             
      Inflammation, Suppurative            |                   3                 3                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Hyperplasia, Mononuclear Cell        |                                                                          |             
      Hyperplasia, Neutrophil              |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                         3  2                                             |             
      Hyperplasia, Macrophage              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |             3                                                            |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Developmental Malformation           |                                           X     X                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                      3  3  3     2                                      2|             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I     +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Lactation                            |                      3                          2                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Alopecia                             |             2  1                                         2  3            |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Compression                          |                      3                          3                        |             
      Hydrocephalus                        |    2                                                                     |             
      Meninges, Inflammation, Suppurative  |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Hemorrhage                           |                                                                      2   |             
      Infiltration Cellular, Lymphocyte    |                      2                                                   |             
      Inflammation, Suppurative            | 4        2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Inflammation, Suppurative            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 5| 0| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 7| 5| 7| 4| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 4| 1| 3| 5| 3| 3| 3| 7| 3| 3| 5| 5| 3| 8| 0| 5| 0| 3| 3| 5| 2| 3| 0|             
                                           | 4| 1| 5| 5| 0| 6| 1| 1| 1| 4| 0| 0| 5| 6| 0| 7| 4| 8| 5| 0| 1| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
      Inflammation, Suppurative            |       4                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                    +                                             |             
      Cornea, Edema                        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                    +                                             |             
      Inflammation, Suppurative            |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +  +     +  +  +|             
      Glomerulosclerosis                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                2        2                                            2   |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |             1                       1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +     +  +  +  +  A  +     +  A     +  +  +  +     +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +     +  +  +  +  A  +     A  A     +  +  +  +     +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +     +  +  +  +  A  +     A  A     +  +  +  +     +  +  +   |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Basophilic Focus                     |                               1                                          |             
      Eosinophilic Focus                   |                         2                          1           2     3   |             
      Infiltration Cellular, Lymphocyte    |    2                             1              2  1           2         |             
      Inflammation, Chronic                |          2                                                               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |          2                             3                                 |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Central Vein, Dilatation             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fat, Inflammation, Chronic Active    |                               3                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +     +  +  +  +  A  +     +  +     +  +  +  +     +  +  +   |             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2              1                                   2        2     3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                   1              1                    2  1     1     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
      Hyperplasia, Squamous                | 2  2     1                       2                                   2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            | 2  2     2                       2                                   2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +     +  +  +  +  A        A  A     +  +  +  +     +  +  +   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Valve, Pigmentation, Melanin,        |                                                                          |             
          Multifocal                       |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Corticomedullary Junction, Hemorrhage|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Pigmentation, Ceroid                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Congestion                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +     +  +  +  +  A  +     +  +     +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M     M  M     +  M  M  +  M  +     M  +     +  M  +  +     +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +     M  +     +  +  +  +  +  M     A  +     +  +  +  +     +  +  +   |             
      Congestion                           |                                                                          |             
      Pars Distalis, Hypertrophy           |             2                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +     +  +  +  +  +  +     A  +     +  +  +  +     +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
      Follicular Cell, Hyperplasia         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Pigmentation, Ceroid                 |                                                                          |             
      Follicle, Cyst                       | 3  3        3     2     2        3                                       |             
      Follicle, Hematocyst                 |                                                    2                 2   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Hydrometra                           |                                        4                                 |             
      Hyperplasia, Cystic                  | 3  3     3  4     3  2  2  3  2  4              2  2           4  2  3   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +     +  +  +  +  +  +     A  +     +  +  +  +     +  +  +   |             
      Hyperplasia, Mononuclear Cell        |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +     +  +  +  +  M  +     +  +     +  +  +  +     +  +  +   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +     +  +  +  M  M  +     +  +     +  +  +  +     +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +     +  +  +  +  M  +     A  +     +  +  +  +     +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
      Hyperplasia, Lymphoid                | 2                                                              3         |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Suppurative            |                               2                                          |             
      Capsule, Fibrosis                    |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +     +  +  +  +  A  +     +  +     +  +  +  +     +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Lactation                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Alopecia                             |    2                                                  1                  |             
      Inflammation, Suppurative            |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Meninges, Inflammation, Suppurative  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Hemorrhage                           |                         2     3                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +     +  +  +  +  +  +     +  +     +  +  +  +     +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +     +  +  +  +  +  +     A  +     +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6| 7| 4| 5| 6| 4| 4| 6| 4| 7| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 3| 5| 3| 3| 5| 3| 2| 3| 5| 8| 3| 5| 9| 4| 5| 5| 3| 5| 3| 5| 3| 5| 3| 5|             
                                           | 9| 0| 8| 0| 0| 8| 0| 9| 1| 6| 0| 0| 8| 7| 3| 8| 6| 9| 5| 0| 8| 0| 5| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Edema                        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +     +  +  +  +  A  +     +  A     +  +  +  +     +  +  +   |             
      Glomerulosclerosis                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                    2  2        3     2   |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +     +  +  +  +  A  +     A  +     +  +  +  +     +  +  +   |             
      Infiltration Cellular, Lymphocyte    |    2        2     1              2              2     2        2  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
      Edema                                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  54        |
      Hyperplasia, Lymphoid                |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Basophilic Focus                     |                                                                          |      1  1.0|
      Eosinophilic Focus                   | 2                                   3                    1               |      8  2.1|
      Infiltration Cellular, Lymphocyte    |                   1  1                                1                  |      9  1.4|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Mixed Cell Focus                     |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Bile Duct, Cyst                      |                                     2                                    |      1  2.0|
      Central Vein, Dilatation             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Inflammation, Chronic Active    |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Atrophy                              | 2                                               2                        |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                         1                             1                  |     10  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |       3     2  1        1                    1  1  1  1  1               |     21  1.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Hyperplasia, Squamous                |                2        2                                                |     14  2.1|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Inflammation, Suppurative            |                         2                                                |     12  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  59        |
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Valve, Pigmentation, Melanin,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Corticomedullary Junction, Hemorrhage|                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |    3                                                                     |      1  3.0|
      Pigmentation, Ceroid                 |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +     M  +  +  +  +  +  +  +  +  +               |  56        |
      Congestion                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  +  +  +  M     +  +  +  +  +  M  +  +  +  +               |  46        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  56        |
      Congestion                           |                                                    2                     |      1  2.0|
      Pars Distalis, Hypertrophy           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +     A  +  +  +  +  +  +  +  +  +               |  57        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |    3                                1           2                        |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Pigmentation, Ceroid                 |                                                                          |      2  2.5|
      Follicle, Cyst                       |                                     2                 3                  |     11  2.6|
      Follicle, Hematocyst                 | 2                                               2  2                     |      5  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Hydrometra                           |       4                                                                  |      3  3.7|
      Hyperplasia, Cystic                  | 3  2        3  2  3  3  2           2  3  3  2  3  3  3  2               |     46  2.8|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Hyperplasia, Mononuclear Cell        |                               3                                          |      1  3.0|
      Hyperplasia, Neutrophil              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  57        |
      Hyperplasia, Lymphoid                |                                                 2                        |      3  2.3|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +     +  M  +  +  +  +  +  +  +  +               |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Macrophage              |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Developmental Malformation           |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    2           2     2                             3  2                  |     12  2.4|
      Hyperplasia, Macrophage              |                                           3                              |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  +  +  +  I     A  +  +  +  M  +  +  +  +  +               |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis                             |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Lactation                            | 2                                                                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Alopecia                             |                                              2                           |      7  1.9|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 4| 4| 7| 7| 7| 6| 4| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 7| 5| 6| 1| 3| 3| 3| 3| 3| 3| 2| 2|              |            |
                                           | 1| 0| 5| 8| 6| 1| 1| 1| 4| 8| 8| 7| 0| 1| 0| 0| 0| 0| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Compression                          |                                                                          |      2  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Meninges, Inflammation, Suppurative  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Hemorrhage                           |                                                                          |      3  2.3|
      Infiltration Cellular, Lymphocyte    |                2                                                         |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   3        |
      Cornea, Edema                        |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  57        |
      Glomerulosclerosis                   |                         2                                                |      1  2.0|
      Infiltration Cellular, Lymphocyte    |       2     2        2                 3                 2               |     12  2.2|
      Cortex, Cyst                         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +  +  +     A  A  +  +  +  +  +  +  +  +               |  54        |
      Infiltration Cellular, Lymphocyte    |             2     1                    1  2  2           2               |     17  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|             
                                           | 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Inflammation, Suppurative            |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                     3                                    |             
      Eosinophilic Focus                   |                   1                                               2      |             
      Infiltration Cellular, Lymphocyte    |             1           1                                      1        1|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                            3        3                                    |             
      Vacuolization Cytoplasmic            |                                                             2            |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Infiltration Cellular,          |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |             1                    2                 1           1        1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                  2  1              1              1     1|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hyperplasia, Squamous                |                            2                                             |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Mineralization                       |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Cardiomyopathy                       |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|             
                                           | 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Atrium, Thrombosis                   |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Cyst                                 |                         3                                                |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                 2                        |             
      Pigmentation, Ceroid                 |    2                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +  +  +     +  +  M  M  +  M  +     +  +     +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +     M  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Follicle, Cyst                       |                                  X                                       |             
      Follicular Cell, Hyperplasia         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Pigmentation, Ceroid                 |                                                                   2      |             
      Follicle, Cyst                       | 3                       2        3              3                        |             
      Follicle, Hematocyst                 |          2        2           3     3                    2  2           2|             
      Periovarian Tissue, Hemorrhage       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +     +|             
      Congestion                           |                                                                   3      |             
      Hydrometra                           | 4                                                     3                  |             
      Hyperplasia, Cystic                  |    2  3  2  3  2  2     2  2  2  3  3  3  3     3  3     4  3  3        3|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hyperplasia, Neutrophil              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|             
                                           | 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hyperplasia, Lymphoid                |          3                    3                          4               |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Suppurative            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |          3                          3              2              2      |             
      Inflammation, Suppurative            |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +  +  +     +  I  +  +  I  +  +     +  +     +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  M  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Alopecia                             |                                                                          |             
      Inflammation, Chronic Active         |                                                 4                        |             
      Inflammation, Suppurative            |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Inflammation, Chronic                |                                                                          |             
      Osteopetrosis                        |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Hydrocephalus                        |                                                                          |             
      Cerebellum, Necrosis, Coagulative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Inflammation, Chronic                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 9| 3| 5| 3| 9| 3| 3| 2| 3| 0| 5| 2| 3| 5| 3| 2| 2| 3| 5| 3|             
                                           | 6| 0| 6| 0| 1| 0| 1| 6| 0| 4| 0| 0| 9| 7| 3| 8| 1| 0| 6| 0| 9| 9| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                        2           3           2        2|             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy                          |                            1                                2     2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |    1                    1     1           1                             2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|             
                                           | 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Inflammation, Chronic                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                           3        3                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Basophilic Focus                     |                      4                                   2               |             
      Clear Cell Focus                     |                                                    2                     |             
      Eosinophilic Focus                   |                   2              2                       1           1   |             
      Infiltration Cellular, Lymphocyte    |             1                    2                 1                 1   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Infiltration Cellular,          |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                      2   |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |    1        2                    3     2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |    2        2        2           2     1  2        1                 1   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hyperplasia, Squamous                |             2  2     1  2                                                |             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Cardiomyopathy                       |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|             
                                           | 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                  1                                       |             
      Mineralization                       |                                                                          |             
      Polyarteritis                        |                                           3        2                     |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Pigmentation, Ceroid                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M        +  +  M  +  +        +  +  +  M     +  M     +  +  M     M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Pars Distalis, Hyperplasia           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Pigmentation, Ceroid                 |                                                                          |             
      Follicle, Cyst                       |             3  3                                                        2|             
      Follicle, Hematocyst                 |    2                             2                       3               |             
      Periovarian Tissue, Hemorrhage       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +  +  +        +  +  +  +     +  +     +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hydrometra                           |                   4                                                      |             
      Hyperplasia, Cystic                  | 3  2        3  3     4  3        3  2  2  3     3  2     3  3  3  2  3  2|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  I  +     M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|             
                                           | 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |             2        3           2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Developmental Malformation           |                X                                                         |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hyperplasia, Lymphoid                |                2                 3     3  2                             2|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                        3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +  +  +  M  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +  +  +  +|             
      Alopecia                             |                                                                   1      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Inflammation, Chronic                |                                                                         3|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Hydrocephalus                        |                                        3                                 |             
      Cerebellum, Necrosis, Coagulative    |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 7| 7| 6| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 3| 3| 3| 3| 1| 5| 5| 3| 3| 1| 2| 5| 3| 3| 5| 2| 3| 3| 5| 3| 3|             
                                           | 6| 0| 8| 8| 1| 0| 0| 2| 5| 8| 8| 0| 0| 7| 9| 6| 0| 0| 8| 9| 0| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |             2                    3                                       |             
      Necrosis, Coagulative                |                         2                                2               |             
      Nephropathy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +  +  +  +  +        +  +  +  +     +  +     +  +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |    1        2  1     1           2  2  2  2        2                 1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3|              |            |
                                           | 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hyperplasia, Lymphoid                |                                           2        3     3               |      6  2.7|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hyperplasia, Lymphoid                |                                                    3     3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Basophilic Focus                     |       3                                                                  |      3  3.0|
      Clear Cell Focus                     |                                                                          |      2  2.5|
      Eosinophilic Focus                   |    2        3  2     1                                2                  |     11  1.7|
      Infiltration Cellular, Lymphocyte    |                                                                          |      8  1.1|
      Mixed Cell Focus                     |                                     4              3                     |      2  3.5|
      Necrosis                             |                                                                          |      2  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Bile Duct, Cyst                      |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
      Fat, Infiltration Cellular,          |                                                                          |            |
          Lymphocyte                       |                2                                                         |      1  2.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      1  2.0|
      Fat, Necrosis                        |                2                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |    2        1                 2                    2                     |     13  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |    2        1  1                          1        3  1  1               |     20  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hyperplasia, Squamous                |                                  2                                       |      6  1.8|
      Inflammation, Suppurative            |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3|              |            |
                                           | 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Cardiomyopathy                       |                               2                                          |      3  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Mineralization                       |                         2        3                                       |      2  2.5|
      Polyarteritis                        |                                                                          |      2  2.5|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |                                                          3               |      1  3.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Pigmentation, Ceroid                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  M  I  +     +  +     +  +  +     +        +  +  +               |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  M               |  48        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |          3                                                               |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  51        |
      Pigmentation, Ceroid                 |                                                                          |      1  2.0|
      Follicle, Cyst                       |                4                          2              4               |     10  2.9|
      Follicle, Hematocyst                 |             2                 3                                          |     12  2.3|
      Periovarian Tissue, Hemorrhage       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +     +  +     +  +  +  +  +        +  +  +               |  56        |
      Congestion                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3|              |            |
                                           | 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrometra                           |                                                                          |      3  3.7|
      Hyperplasia, Cystic                  |    3  3  3  4  2     1  3     4  2  3  2  3        3  2  4               |     52  2.7|
      Inflammation, Suppurative            |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Mediastinal, Hyperplasia, Lymphoid   |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  48        |
      Congestion                           |             2                                                            |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Hyperplasia, Lymphoid                |       3                                                  3               |      6  3.2|
      Hyperplasia, Macrophage              |                                           3                              |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Developmental Malformation           |                                     X                 X                  |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    3           2                    2                                    |     12  2.4|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  48        |
      Hemorrhage                           |                                     3                                    |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +     +  M     +  +  +     +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +     +  +     +  +  +  +  +        +  +  +               |  52        |
      Alopecia                             |                                        3                                 |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Osteopetrosis                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 7| 3| 5| 3| 8| 5| 3| 2| 3| 5| 3| 5| 5| 3| 2| 3|              |            |
                                           | 8| 1| 0| 0| 1| 1| 8| 1| 5| 6| 1| 0| 0| 5| 0| 5| 8| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Cerebellum, Necrosis, Coagulative    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |    2                                                                     |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                                     3                                    |      7  2.4|
      Necrosis, Coagulative                |                                                                          |      2  2.0|
      Nephropathy                          |       2              1                                                   |      5  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +     +  +     +  +  +     +        +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |    3           2     2        1           1        2  1                  |     22  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|             
                                           | 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  M  A   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Hyperplasia, Lymphoid                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  M  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Autolysis                            |                                                                      4   |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                      1                 3                                 |             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Inflammation, Suppurative            | 1                                                           1            |             
      Mixed Cell Focus                     |             2                                                            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +  +         |             
      Fat, Necrosis                        |                                                             3  4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          1                                                     2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    | 1                    2     1                 1     1  1        2  1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +  +  A   |             
      Hyperkeratosis                       |                                                          2               |             
      Hyperplasia, Squamous                |             2  2     2  2                                                |             
      Inflammation, Chronic Active         |             2  2                                                         |             
      Inflammation, Suppurative            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Infiltration Cellular, Lymphocyte    |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Hypertrophy                          |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|             
                                           | 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  M  M  +     +  +  +  +  M  +  M     +     M  M     +  M  +  A   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  I   |             
      Follicle, Cyst                       | 3                                   3        4     3                     |             
      Follicle, Hematocyst                 |                            2           2                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  A   |             
      Hydrometra                           |                                                 4                        |             
      Hyperplasia, Cystic                  | 3  2  3  3  3  3     3  2  3  3  2  1  4     2     3  2  3  2  3  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Hyperplasia, Erythrocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +  M  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Mediastinal, Hyperplasia, Lymphoid   |       4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     M  +  +  +     +  M  M  +  +  +  I     M     M  +     +  M  +  A   |             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     +  M  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Erythrocyte             |                                                                          |             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A   |             
      Alopecia                             |                   3                             1                        |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 4| 3| 3| 5| 3| 5| 2| 3| 5| 3| 3| 3| 6| 5|             
                                           | 0| 6| 0| 0| 5| 0| 5| 0| 1| 1| 1| 4| 0| 0| 8| 0| 6| 9| 1| 6| 0| 0| 0| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Osteopetrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
      Degeneration                         |             3                                                            |             
      Demyelination                        |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Congestion                           |                                                       1                  |             
      Hyperplasia, Macrophage              |                         1                                                |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Glomerulosclerosis                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2           2                                2                 2         |             
      Metaplasia, Cartilagenous            |                                                                          |             
      Necrosis, Coagulative                |       2                             2                                    |             
      Nephropathy                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  A   |             
      Dilatation                           |             4                                                            |             
      Infiltration Cellular, Lymphocyte    | 1        1     1        2  2           1     1     1           2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|             
                             DAY ON TEST   | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|             
                                           | 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Autolysis                            |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                        2           2                     |             
      Eosinophilic Focus                   |          2  3                    1        2        2                     |             
      Infiltration Cellular, Lymphocyte    |                      3                       3           1              2|             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  A  +     +     +     +  +  +  +  +     +              +|             
      Atrophy                              |          4                                                               |             
      Infiltration Cellular, Lymphocyte    |    1                 2     2                    1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Infiltration Cellular, Lymphocyte    |    1                 1     1                 1  1        2              1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  A  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  A  +  +     +     +     +  +  +  +  +     +              +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                   3  2           2     2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Infiltration Cellular, Lymphocyte    |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +     +     +     +  +  +  +  M     +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +     +     +     +  +  +  +  M     +              +|             
      Hypertrophy                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|             
                             DAY ON TEST   | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|             
                                           | 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +     +     +     +  +  +  +  M     +              +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  M  +     M     +     M  I  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Infiltration Cellular, Lymphocyte    |    3                                                                    2|             
      Follicle, Cyst                       |                            2                                             |             
      Follicular Cell, Hyperplasia         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +              +                                                         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Follicle, Cyst                       |          2                       3              2                        |             
      Follicle, Hematocyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +     +     +  +  +  +  +  +  +     +  +           +|             
      Hydrometra                           |                                              3                           |             
      Hyperplasia, Cystic                  | 1  2     3  2     4  4           2  2  2        2  3     2  3           4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Hyperplasia, Erythrocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Mediastinal, Hyperplasia, Lymphoid   |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Hyperplasia, Lymphoid                |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Hyperplasia, Lymphoid                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Erythrocyte             | 3                                                                        |             
      Hyperplasia, Lymphoid                |             3  2           3                 3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Atrophy                              |          4                                                               |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  M  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  A  +     +     +     +  +  +  +  +     +              +|             
      Alopecia                             |                                        2                                 |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 6| 6| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 5| 4| 7|             
                             DAY ON TEST   | 1| 3| 5| 9| 3| 8| 9| 3| 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 5| 3| 5| 5| 2| 5| 3|             
                                           | 7| 0| 8| 4| 1| 7| 4| 0| 8| 0| 8| 0| 6| 1| 1| 1| 0| 0| 8| 0| 5| 8| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
      Hyperplasia                          |          2                                                               |             
      Necrosis                             |          2                                                               |             
      Osteopetrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Necrosis                             |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration                         |                                                                          |             
      Demyelination                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  A  +     +     +     +  +  +  +  +     +              +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                            2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +     +     +     +  +  +  +  +     +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  M                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  A  +  +     +     +     +  +  +  +  +     +              +|             
      Glomerulosclerosis                   |                   4                                                      |             
      Infiltration Cellular, Lymphocyte    |    2                       2                 2                           |             
      Metaplasia, Cartilagenous            |                                                                          |             
      Necrosis, Coagulative                |                                        2                                 |             
      Nephropathy                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  A  A  +     +     +     +  +  +  +  +     +              +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1                    1                             1     1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|              |            |
                             DAY ON TEST   | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5|              |            |
                                           | 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +     +  +  +  +     +  +  +  +  +  +  A     +  I                  |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | M     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  53        |
      Autolysis                            |                                                                          |      1  4.0|
      Basophilic Focus                     |                                                 2                        |      1  2.0|
      Clear Cell Focus                     |                                                                          |      2  2.0|
      Eosinophilic Focus                   |                               2     3                                    |      9  2.1|
      Infiltration Cellular, Lymphocyte    |                1                 1     3                                 |      8  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mixed Cell Focus                     |                               2                                          |      2  2.0|
      Necrosis                             |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis                        |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Atrophy                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |       1        1                 2        1                              |     10  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
      Infiltration Cellular, Lymphocyte    |       1        3  2              2     1  1        1  1                  |     23  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                | 3                                                                        |      9  2.2|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  45        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
      Cardiomyopathy                       |                                                       1                  |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|              |            |
                             DAY ON TEST   | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5|              |            |
                                           | 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +     +  +  M  +     +  +  +  +  +  +  +     +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +     +  +  M  +     +  +  +  +  +  +  +     +  +                  |  47        |
      Hypertrophy                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +     +  +  M  +     +  +  +  +  +  +  +     +  +                  |  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     +     +  +  M  +     +  M  +  M  M  +  +     +  +                  |  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.5|
      Follicle, Cyst                       |                                                       2                  |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  50        |
      Follicle, Cyst                       |             3                                   3     4                  |     10  3.0|
      Follicle, Hematocyst                 |                      2              3                                    |      4  2.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +                  |  56        |
      Hydrometra                           |    4                                            4     3                  |      5  3.6|
      Hyperplasia, Cystic                  | 2     3     2  3  3  3     2  2  2  2  2  3        3                     |     47  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +  +  +  +     +  +  +  +  +  +  A     +  +                  |  48        |
      Hyperplasia, Erythrocyte             |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +     +  +  +  +     +  +  +  +  M  +  +     +  +                  |  40        |
      Hyperplasia, Lymphoid                |                                     3                                    |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +     +  +  +  +     +  +  +  +  +  +  M     +  +                  |  45        |
      Hyperplasia, Lymphoid                |             3                             3        3                     |      4  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  49        |
      Hematopoietic Cell Proliferation     |                                                       3                  |      1  3.0|
      Hyperplasia, Erythrocyte             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|              |            |
                             DAY ON TEST   | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5|              |            |
                                           | 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                    2                     |      6  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +     +  +  +  +     +  I  +  +  +  +  +     +  I                  |  47        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
      Alopecia                             |       2        2                                                         |      5  2.0|
      Hyperplasia, Squamous                |       2                                                                  |      1  2.0|
      Inflammation, Chronic Active         |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Osteopetrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  3.0|
      Demyelination                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Congestion                           |                                                                          |      1  1.0|
      Hyperplasia, Macrophage              |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4|              |            |
                             DAY ON TEST   | 0| 5| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 5|              |            |
                                           | 0| 6| 0| 6| 0| 0| 1| 1| 8| 1| 0| 1| 0| 0| 9| 8| 6| 1| 1| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  48        |
      Glomerulosclerosis                   |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |             2                    2                    2                  |     10  2.0|
      Metaplasia, Cartilagenous            |                            2                                             |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      3  2.0|
      Nephropathy                          |                   1                                   1                  |      4  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +  +  +  +     +  +  +  +  +  +  +     +  +                  |  47        |
      Dilatation                           |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    | 2     1     1  1  2           1                                          |     19  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|             
                                           | 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  M  +  +  +  +  A     +  +  +  +  A  A  +  +  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  A     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                   2        4                             3               |             
      Infiltration Cellular, Lymphocyte    |    1        2                                                            |             
      Inflammation, Suppurative            |                                                                   2      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                       2                  |             
      Perivascular, Fibrosis               |             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2        4                  |             
      Infiltration Cellular, Lymphocyte    |    1  2        2  1                                         1  1         |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1           2  1  2                       1     3  1  1  2  1  2  3   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |             3              2           2                                 |             
      Inflammation, Suppurative            |             2                          2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                          1               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Atrioventricular Valve, Fibrosis     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|             
                                           | 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  M  M     +  +  +  M  M  +  +  M  +  +  +  +  +  M  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      2                                                   |             
      Pars Distalis, Hyperplasia           |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                             1            |             
      Follicular Cell, Hyperplasia         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fat, Pelvic, Hemorrhage              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Ceroid                 |    3                                                                     |             
      Follicle, Cyst                       |                      4                                               3   |             
      Follicle, Hematocyst                 |          2                 3                                   3         |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 2                        |             
      Hydrometra                           |                            4                 3                       4   |             
      Hyperplasia, Cystic                  |    3  2  3  2  2  2  4        2  2  3     2     2  2  2  2  4  3  4     3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M  +  +  +  M  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  I     +  +  +  +  M  A  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3                                                   |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 4| 7| 5| 4| 7| 7| 4| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 4| 5| 3| 2| 5| 3| 3| 5| 3| 3| 9| 5| 3| 5| 0| 3| 3| 2| 3| 5| 2|             
                                           | 8| 0| 5| 0| 6| 6| 0| 9| 8| 1| 0| 6| 0| 0| 5| 4| 0| 6| 3| 0| 0| 9| 1| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lactation                            |             2                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  A     +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change                         |                                              2                           |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                 2  3                 2   |             
      Metaplasia, Cartilagenous            |                                                          1               |             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy                          |                               1                 2                 1      |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2  2  1     2  1              2  1              2                 2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|             
                                           | 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  I  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  I|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +     M     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Basophilic Focus                     | 3                                                                        |             
      Eosinophilic Focus                   |    3  3        2                                                         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 3                                                                        |             
      Perivascular, Fibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fat, Necrosis                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  A  A  +     +     +  +|             
      Atrophy                              | 4                                                                        |             
      Infiltration Cellular, Lymphocyte    |    1  1        1                          2                              |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     | 4                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Infiltration Cellular, Lymphocyte    |    1           1                             2           2     1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +     +     +  +|             
      Hyperplasia, Squamous                |       2                                                              2   |             
      Inflammation, Suppurative            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +     A     +  +  A  A  A  +     +     A  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Cardiomyopathy                       |                         2                                                |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       |                                     3                                    |             
      Necrosis                             |                                                                          |             
      Atrioventricular Valve, Fibrosis     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|             
                                           | 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Congestion                           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  I  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  M     +     +  +  +  +  +  +     +     +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M     +     +  +  +  +  +  +     +     +  +|             
      Infiltration Cellular, Lymphocyte    |       1                                                                  |             
      Follicular Cell, Hyperplasia         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fat, Pelvic, Hemorrhage              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     M     +  +  +  +  +  +     +     +  +|             
      Pigmentation, Ceroid                 |                                                                          |             
      Follicle, Cyst                       |                3           3                                   3        2|             
      Follicle, Hematocyst                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Congestion                           |                                                                          |             
      Hydrometra                           |       4                                               4                  |             
      Hyperplasia, Cystic                  | 2  3     4  3     3  3  3  3        2     3  3  2        4     2     2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     A     +  +  +  A  A  +     +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +     +     +  +  M  +  +  +     +     +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +     A     +  +  +  A  A  M     +     +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +     A     +  +  +  +  A  +     +     +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                X                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  M  +     +     +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 0| 4| 7| 4| 7| 5| 4| 6| 7| 4| 4| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 3| 9| 3| 3| 3| 5| 3| 3| 0| 5| 0| 5| 3| 0| 2| 8| 0| 5| 5| 3| 5| 9| 3|             
                                           | 9| 9| 0| 2| 7| 0| 0| 6| 0| 0| 9| 8| 4| 8| 1| 4| 2| 9| 1| 6| 8| 0| 8| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Lactation                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
      Compression                          | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  +  +     +     +  +|             
      Fatty Change                         |                                                                          |             
      Infarct                              |                                                                3         |             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
      Metaplasia, Cartilagenous            |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy                          |       1                                   2                              |             
      Cortex, Cyst                         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +     +     +  +  +  +  A  +     +     +  +|             
      Infiltration Cellular, Lymphocyte    |    2                    1  2              2        1     1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +     A  A  +  +  +     M  +  +  +  A  +  A  +     +               |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     A  A  +  +  +     +  +  +  +  +  +  A  +     +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     A  A  M  +  +     +  +  +  +  +  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +     A  A  +  A  +     +  +  +  +  A  +  A  +     +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +     A  A  +  +  +     +  +  +  +  A  +  A  +     +               |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  61        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Eosinophilic Focus                   |       3                                   2                              |      8  2.8|
      Infiltration Cellular, Lymphocyte    |                                  1           4     1                     |      5  1.8|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                          2               |      1  2.0|
      Necrosis                             |                                           4                              |      3  3.0|
      Perivascular, Fibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   2        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     A  +  +  +  +     +  +  +  +  +  +  A  +     +               |  56        |
      Atrophy                              |                                                                          |      3  3.3|
      Infiltration Cellular, Lymphocyte    |       2                          1                                       |     12  1.3|
      Inflammation, Suppurative            |                               2                                          |      1  2.0|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  59        |
      Infiltration Cellular, Lymphocyte    |    1  1        1                 1           1           2               |     23  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     A  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     A  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
      Hyperplasia, Squamous                |                                                          2               |      6  2.2|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     A  A  +  A  +     +  +  +  +  +  +  A  +     +               |  50        |
      Mineralization                       |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                  1  1  1                                 |      4  1.0|
      Mineralization                       |                               2                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                           2                              |      1  2.0|
      Atrioventricular Valve, Fibrosis     |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  A  +  A  +     +  +  +  +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  A  +  A  +     +  +  +  +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  A  +  A  +     +  +  +  +  +  +  +  +     +               |  57        |
      Congestion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     A  +  +  +  +     +  +  +  +  +  +  A  +     +               |  56        |
      Infiltration Cellular, Lymphocyte    |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  M  M  +  +     +  M  M  +  +  M  +  +     +               |  47        |
      Hyperplasia                          |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  I  +  +  +     M  +  +  +  +  +  +  +     +               |  56        |
      Pars Distalis, Cyst                  |                                                    3                     |      2  2.5|
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  M  +  +     +  +  +  +  +  +  +  +     +               |  58        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
      Fat, Pelvic, Hemorrhage              |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  59        |
      Pigmentation, Ceroid                 |                                                                          |      1  3.0|
      Follicle, Cyst                       |                                     4        3  4                        |      9  3.2|
      Follicle, Hematocyst                 |                                                          3               |      5  2.6|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hydrometra                           |                                           2                              |      6  3.5|
      Hyperplasia, Cystic                  | 3  1  1              2  3        3  2  2     1  3  2     3               |     47  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     M  +  +  +  +     +  +  +  +  +  +  A  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  I     M  +  +  +  +     M  M  +  +  +  +  M  +     +               |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     M  +  +  +  +     +  +  +  +  +  +  A  M     +               |  49        |
      Congestion                           |                               3                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  A  +  +  +     +  +  +  +  +  +  A  +     +               |  55        |
      Congestion                           |                                                                          |      1  3.0|
      Developmental Malformation           |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                      3        3                                          |      2  3.0|
      Hyperplasia, Lymphoid                |       2                                                                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
      Atrophy                              |                                           3                              |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  M  +     +               |  59        |
      Lactation                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Alopecia                             |       3                             2                                    |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  61        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  A  +  +  +     +  +  +  +  +  +  +  +     +               |  57        |
      Compression                          |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Hemorrhage                           |                               3                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
      Inflammation, Suppurative            |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  A  +     +               |  56        |
      Fatty Change                         |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 4| 4| 5| 4| 5| 7| 4| 7| 7| 7| 7| 5| 4| 5| 7| 4| 7|              |            |
                             DAY ON TEST   | 5| 4| 3| 5| 6| 5| 1| 8| 3| 5| 0| 3| 3| 3| 4| 5| 2| 3| 5| 3|              |            |
                                           | 6| 0| 0| 8| 2| 4| 9| 3| 1| 8| 3| 0| 0| 0| 5| 6| 6| 0| 8| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    | 1     2                 2        2  1                                    |      9  1.9|
      Metaplasia, Cartilagenous            |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                           2                              |      1  2.0|
      Nephropathy                          |                                                                          |      5  1.4|
      Cortex, Cyst                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     M  A  +  +  +     +  +  +  +  +  +  A  +     +               |  54        |
      Infiltration Cellular, Lymphocyte    |       2                          2     2                 1               |     19  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|             
                                           | 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  A  +  +  +  +     +  I  +  +  +  +  +  +  A  +  I  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |    2              4                       3                              |             
      Fatty Change                         |                                                                         2|             
      Hemorrhage                           |                                                                3         |             
      Infiltration Cellular, Lymphocyte    |                            1                                             |             
      Mixed Cell Focus                     |                         2                                                |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Fat, Inflammation, Suppurative       |                                                                          |             
      Fat, Necrosis                        |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               1                          2               |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1              2     1  1                 1           2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia, Squamous                |    2              2                       3                              |             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Suppurative            |    2              2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|             
                                           | 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Suppurative   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
      Hypertrophy                          |                            2           2     2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2           2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M     +  M  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  M|             
      Pars Distalis, Cyst                  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                 4                        |             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +     +  +   |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                                             3     3  3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  M  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2        3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|             
                                           | 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                   2                                            3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  +     +  I  +  +  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M     +  M  +  M  M  M     M  M  M  M  M  M  M  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                    2                     |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                    1                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |          1                                                               |             
      Inflammation, Chronic Active         |                                              1                           |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                       +   |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                              +                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                   3                                                      |             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy                          | 1  1  2     1     2     1  1  1  1     1  4  1  1           1     1  1   |             
      Cortex, Cyst                         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 6| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 5| 2| 4| 2| 2| 2| 3| 5| 3| 2| 3| 3| 5| 5| 9| 3| 5| 3| 2| 5|             
                                           | 0| 9| 0| 1| 9| 8| 9| 9| 9| 9| 9| 0| 8| 0| 9| 0| 0| 6| 5| 0| 0| 6| 0| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                            1                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|             
                                           | 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Hyperplasia, Lymphoid                |             3                                      3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  I  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            1                                             |             
      Clear Cell Focus                     |                               2  2                                       |             
      Eosinophilic Focus                   |       2              3  2                                                |             
      Fatty Change                         |                               2                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +  M                                          |             
      Fat, Inflammation, Suppurative       |                            2                                             |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Atrophy                              |                      3                 4                                 |             
      Cyst                                 |                                        4                                 |             
      Infiltration Cellular, Lymphocyte    |                                           2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2                 1     3           2  1                 1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Serosa, Inflammation, Suppurative    |                            4                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Cyst Epithelial Inclusion            |                                     X                                    |             
      Hyperplasia, Squamous                |          2  2        2                                2                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |          2                                            2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|             
                                           | 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Capsule, Inflammation, Suppurative   |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M     +  +  M  +  +  +  M  +  I  +  +  M  +        +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +                          +  +     +  +                       +   |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     | 3     3                          3  3     3  3                       3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M        +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Congestion                           |                                                       3        2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Congestion                           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|             
                                           | 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                    X                     |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hyperplasia, Lymphoid                |                            2           3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  I  +     +  M  +  I  +  +  +  +  +  +  A  +  I        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M     M  M  +  M  M  M  M  +  M  M  M  M  M        M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Alopecia                             |                   1                                                      |             
      Hyperkeratosis                       | 3                                                                        |             
      Inflammation, Suppurative            | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hyperostosis                         |          2                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                    +                                                |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hydronephrosis                       |                   3                                                      |             
      Infiltration Cellular, Lymphocyte    |                   3                                                  1  2|             
      Necrosis, Coagulative                |                                                       2                  |             
      Nephropathy                          | 2  1  2  1  1        2  1        1  1  1  2  2  1  2  2        1     1   |             
      Cortex, Cyst                         |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 5| 4| 4| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 5| 3| 2| 2| 5| 2| 2| 3| 3| 2| 5| 2| 9| 5| 5| 3| 5| 3| 5|             
                                           | 0| 9| 0| 0| 9| 8| 6| 0| 9| 8| 6| 9| 9| 0| 0| 9| 8| 9| 1| 8| 8| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                              1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Dilatation                           |                                     3                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2|              |            |
                                           | 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +  +        +  +     +  +  +  M  +     +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
      Hyperplasia, Lymphoid                |                                           3        3     3               |      6  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  54        |
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     | 2                                      2                                 |      3  1.7|
      Clear Cell Focus                     |                                                    1                     |      3  1.7|
      Eosinophilic Focus                   | 2                                                  2     2               |      9  2.4|
      Fatty Change                         |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   3        |
      Fat, Inflammation, Suppurative       |                                                                          |      1  2.0|
      Fat, Necrosis                        |                   3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  58        |
      Atrophy                              |                                                                          |      4  2.5|
      Cyst                                 |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Infiltration Cellular, Lymphocyte    | 1  2     1        2           1           1     1        1               |     21  1.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperplasia, Squamous                | 3        2                    2                                          |     10  2.2|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2|              |            |
                                           | 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Cardiomyopathy                       |          2                                                               |      2  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Capsule, Inflammation, Suppurative   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Hyperplasia                          |       2                                                                  |      3  1.7|
      Hypertrophy                          |       2                                                                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Hyperplasia                          | 3                                                                        |      4  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     +  +        I  +     M  +  +  +  +     +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  56        |
      Pars Distalis, Cyst                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   1        |
      Necrosis                             |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Granuloma Sperm                      |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +              +                                                   |  12        |
      Inflammation, Suppurative            |       3                                                                  |      1  3.0|
      Duct, Dilatation                     |                      4                                                   |     11  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Dilatation                           |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2|              |            |
                                           | 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +        +  +     M  +  +  +  +     +               |  59        |
      Congestion                           |          2                                                               |      5  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                                        X                                 |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |          2                                                               |      5  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | I  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M     M  M        M  M     +  M  M  M  M     M               |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  59        |
      Alopecia                             |          2        3                                                      |      4  2.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Hyperostosis                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  58        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Congestion                           |                                        1                                 |      1  1.0|
      Edema                                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 4| 7| 4| 4| 7| 4| 4| 6| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 5| 5| 2| 5| 5| 2| 5| 5| 9| 3| 2| 3| 2| 5| 2|              |            |
                                           | 0| 9| 9| 9| 5| 8| 6| 9| 8| 8| 9| 6| 8| 6| 0| 9| 0| 9| 8| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   3        |
      Cataract                             |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                 +                        |   5        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |          2        2                                                      |      6  2.2|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Nephropathy                          | 2  1  1  1           1        1        1  1  2  1  1     1               |     45  1.3|
      Cortex, Cyst                         |                                                                          |      2  1.5|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +        +  +     +  +  +  +  +     +               |  60        |
      Dilatation                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |          1                                                               |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|             
                                           | 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +        +  I     +  +        +     +  +     A        +  +  +  +     +|             
      Hemorrhage                           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia, Lymphoid                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +  +     +  +        +     +  +     A        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia, Lymphoid                |             4                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +     +  +  +     +     +  +     +  +     +  +  +  +     +|             
      Angiectasis                          |    3                                            2        3               |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |    2                                                        3            |             
      Eosinophilic Focus                   |                      2           3              2                        |             
      Fatty Change                         |                2                                   2                     |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 3                                         1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Atrophy                              |                                                             4            |             
      Cyst                                 |                                                             4            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |    1                 1  1        1        3                    2        2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia, Squamous                |                         2                       2           2            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Inflammation, Chronic                |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|             
                                           | 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Atrium, Thrombosis                   |                                           4                              |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |    2                    1                                         2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +        M  M     +  +        +     +  +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +  +     +  +        +     +  +     +        M  +  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Follicle, Degeneration               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                           4                              |             
      Abdominal, Inflammation, Suppurative |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +           +     +                                             |             
      Inflammation, Suppurative            |                      3                                                   |             
      Duct, Dilatation                     |          4                 4                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Atrophy                              |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|             
                                           | 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +  +     M  +        +     +  +     +        +  +  +  +     +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +     +  +        +     +  +     M        +  +  +  +     +|             
      Congestion                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Atrophy                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M        M  M     M  M        M     M  M     M        M  M  M  +     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Alopecia                             |    2  3                                                                  |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Congestion                           | 1                                                                        |             
      Emphysema                            |                                                 3                        |             
      Hyperplasia, Macrophage              |    3                             2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       3                                                                  |             
      Alveolus, Giant Cell                 |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 5| 5| 3| 3| 5| 3| 3| 5| 5| 2| 5| 3| 2| 5| 2| 5| 5| 2| 3| 2| 2| 5| 3|             
                                           | 7| 9| 5| 5| 0| 0| 5| 0| 0| 6| 8| 9| 8| 0| 9| 8| 3| 6| 8| 9| 0| 9| 9| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |    1        1  1     1  1        2     1  2     1        1  1  1  1     1|             
      Cortex, Cyst                         |                                                                   2      |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                1         |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +  +     +  +        +     +  +     +        +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|             
                                           | 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +     +  +  M     +  +     +  A     +  M  A  +        +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
      Hyperplasia, Lymphoid                |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  M  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  A  A  +        +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +     +  +|             
      Angiectasis                          |                                        3                                 |             
      Basophilic Focus                     |          2                                                               |             
      Clear Cell Focus                     |          2                 2                                             |             
      Eosinophilic Focus                   | 3                                                                        |             
      Fatty Change                         |                                                                          |             
      Hemorrhage                           |                                                          3               |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation, Suppurative            |                                                 4              2         |             
      Mixed Cell Focus                     |          2                                                               |             
      Necrosis                             |                            3                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                            1  1        1                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Infiltration Cellular, Lymphocyte    |       1  1  2     1        1  1     1  1                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Hyperplasia, Squamous                |                               2              2                           |             
      Inflammation, Suppurative            |                               1              1                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Cyst                                 |                2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|             
                                           | 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                 4                        |             
      Atrium, Thrombosis                   |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          | 3              1                                      2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  M        +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +     +  +  +     +  +     M  M     +  +  +  +        M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +     +  +     +  M     +  +  +  M        +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Follicle, Degeneration               |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +           +            |             
      Hemorrhage                           |                                                             4            |             
      Necrosis                             |                                                                          |             
      Abdominal, Inflammation, Suppurative |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Inflammation, Chronic                |                                                                3         |             
      Mineralization                       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +                    +              +              +            |             
      Inflammation, Suppurative            |          3                                                               |             
      Duct, Dilatation                     |    3                          3              3              4            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +     +  +  +     +  +     +  M     +  +  +  +        +|             
      Infiltration Cellular, Lymphocyte    |                               1                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Atrophy                              |                                                             2            |             
      Mineralization                       |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Hyperplasia, Neutrophil              |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|             
                                           | 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +     +  +     M  M     M  I  M  +        +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Congestion                           | 3                                                                        |             
      Inflammation, Suppurative            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Inflammation, Suppurative            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +  +  I     +  +     +  +     +  +  +  +        +|             
      Atrophy                              |                                                          3               |             
      Inflammation, Suppurative            |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M     M  M  M     M  M     M  M     M  M  M  +        M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Suppurative            |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Inflammation, Suppurative            |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Congestion                           |                                                                          |             
      Emphysema                            |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Chronic Active         |                                                       3                  |             
      Inflammation, Suppurative            |                                                 4                        |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    3  2                                                                 2|             
      Alveolus, Giant Cell                 |                                                       3                  |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4| 7| 4| 4| 5| 4| 6| 7| 4| 4| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 2| 2| 5| 2| 2| 1| 5| 2| 3| 5| 2| 4| 5| 6| 2| 6| 2| 5| 5| 3|             
                                           | 9| 9| 0| 0| 0| 9| 9| 5| 9| 9| 8| 8| 9| 0| 8| 9| 9| 8| 8| 3| 6| 9| 8| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                               3                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                    +                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +     +  +     +  +     +  +  +  +        +|             
      Infiltration Cellular, Lymphocyte    |                               3                                          |             
      Inflammation, Suppurative            |                                                 4                        |             
      Nephropathy                          | 2  1  1  1  1  1  1     1  1  2     1  1     2        2     2  1        1|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +     +  +     +  A     +  +  +  +        +|             
      Infiltration Cellular, Lymphocyte    |       1                       1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  M  M     +  +  A  I  +        +               |  40        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  45        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +               |  56        |
      Angiectasis                          |                                                                          |      4  2.8|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Clear Cell Focus                     |                   1     3           1                                    |      7  2.0|
      Eosinophilic Focus                   |             3     2     3           1                                    |      8  2.4|
      Fatty Change                         |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Mixed Cell Focus                     |    2                                                                     |      2  2.0|
      Necrosis                             |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                             +                     |   3        |
      Fat, Necrosis                        |                      2                             3                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  50        |
      Atrophy                              |                         2                                                |      2  3.0|
      Cyst                                 |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  50        |
      Infiltration Cellular, Lymphocyte    | 1     1     2           1  2           1     1           1               |     23  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
      Hyperplasia, Squamous                |                      2                    2              3               |      8  2.1|
      Inflammation, Suppurative            |                      2                    1                              |      4  1.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  47        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Suppurative            |             2              2                                             |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  50        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
      Hypertrophy                          | 2                                                                        |      7  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  49        |
      Hyperplasia                          |                            3                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +     +  +  +  M  +        +               |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  M     +  +  +  +  +        +               |  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
      Follicle, Degeneration               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +  +                           |   5        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Abdominal, Inflammation, Suppurative |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                                   +                        |  10        |
      Inflammation, Suppurative            |             3                                                            |      3  3.0|
      Duct, Dilatation                     |                                                 3                        |      7  3.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  A  +  +  +  +  A     +  +  I  +  +        +               |  47        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  48        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Hyperplasia, Neutrophil              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  M     +  +  +  +  +        +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  M  +  +  +  M     +  +  +  +  +        +               |  41        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  M     +  +  +  +  +        +               |  48        |
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +        +               |  50        |
      Developmental Malformation           |                                     X                                    |      1     |
      Hyperplasia, Lymphoid                |          2           3                 2                                 |      4  2.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        I               |  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M        M               |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  A  +  +  +  +  A     +  +  +  +  +        +               |  50        |
      Alopecia                             |                                                                          |      2  2.5|
      Cyst Epithelial Inclusion            |                   X                                                      |      1     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +        +               |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 6| 4| 7| 7| 5| 7| 7| 4| 4| 7|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 2| 4| 2| 3| 2| 5| 7| 5| 3| 2| 5| 2| 3| 5| 5| 2|              |            |
                                           | 0| 9| 0| 8| 9| 3| 9| 0| 9| 3| 3| 8| 0| 9| 8| 9| 0| 6| 5| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |      A     |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                     1                                    |      2  1.0|
      Emphysema                            |                                                                          |      1  3.0|
      Hyperplasia, Macrophage              |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Pigmentation                         |          2                                                               |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.5|
      Alveolus, Giant Cell                 |                                                                          |      1  3.0|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Lymphocyte             |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Inflammation, Suppurative            |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +              +                                                |   3        |
      Cataract                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +              +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +               |  51        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Nephropathy                          | 1  1  2  1  2     1  1  1  1        1  1  2  1  1        2               |     46  1.2|
      Cortex, Cyst                         |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  A     +  +  A  +  +        +               |  47        |
      Infiltration Cellular, Lymphocyte    |                   1                             1                        |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|             
                                           | 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +        +  M     +     +  +     +  +  A  +  +     M   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
      Hyperplasia, Lymphoid                |    3  3                                            3                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +  +     +  +|             
      Basophilic Focus                     |                         2                                2               |             
      Clear Cell Focus                     | 2  2  2        2              3     1                       2        2   |             
      Eosinophilic Focus                   | 2  2        2  1              3                    3                 2   |             
      Fatty Change                         |                                                    2                     |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mixed Cell Focus                     |                                                 2                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +        +  +     +     +  A     +  +  +  +  +     +   |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
      Infiltration Cellular, Lymphocyte    | 1  1              2                                                  2   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
      Hyperplasia, Squamous                |       2     2     2                                                      |             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +        +  +     +     +  A     +  +  A  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
      Cardiomyopathy                       |                   3                                      2               |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|             
                                           | 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
      Hypertrophy                          |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation, Ceroid                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +        M  +     +     +  +     M  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +        +  +     +     +  M     +  +  M  +  +     +   |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                                              +   |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Dilatation                     |       2                                                              3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  A  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
      Dilatation                           |                                           3                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     M   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +        +  +     +     +  M  +  +  +  A  +  +     +   |             
      Congestion                           |                                                                          |             
      Sinus, Dilatation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  A  +  +     +   |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|             
                                           | 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Inflammation, Pyogranulomatous       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +        +  +     +     +  A     +  +  M  +  +     +   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  M        M  M     M     M  M     M  M  M  +  M     M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
      Alopecia                             |                            3                                             |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Parakeratosis                        |                                                                          |             
      Sebaceous Gland, Metaplasia, Squamous|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +        +  +     +     +  A     +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |       2                                                                  |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
      Inflammation, Suppurative            |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Proliferative                   |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Hyperplasia, Squamous         |                                                                          |             
      Pinna, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cornea, Inflammation, Chronic        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 7| 3| 4| 7| 6| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 3| 2| 3| 1| 2| 3| 3| 5| 5| 3| 2| 5| 3| 5| 1| 9| 5| 2| 7| 8| 2| 3| 5| 2| 5|             
                                           | 0| 9| 0| 5| 9| 0| 0| 5| 6| 0| 9| 6| 0| 8| 8| 3| 6| 9| 5| 3| 9| 0| 5| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +        +  +     +     +  +     +  +  +  +  +     +   |             
      Amyloid Deposition                   |                               1                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                    2                 2   |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 1  1  1  3  1  1  1        1  1     1     1        1  1  4  2  1     1   |             
      Cortex, Cyst                         |             1                                                            |             
      Pelvis, Epithelium, Hyperplasia      | 3                                                                        |             
      Renal Tubule, Hyperplasia, Cystic    |                   1                                                      |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +        +  +     +     +  +     +  +  A  +  +     +   |             
      Infiltration Cellular, Lymphocyte    |    1                          1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|             
                             DAY ON TEST   | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|             
                                           | 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +     A  +  +  +     +  +  +  +  M     M     +  +     M  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Hyperplasia, Lymphoid                |                                        3              2                  |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Basophilic Focus                     | 2                                                                        |             
      Clear Cell Focus                     | 2     1                    2     2     3                                 |             
      Eosinophilic Focus                   |                   1                                2                     |             
      Fatty Change                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                     2                                    |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                4         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Fat, Inflammation, Chronic Active    |                                                       3                  |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
      Atrophy                              |                            2                                   3         |             
      Inflammation, Chronic                |                                                                          |             
      Polyarteritis                        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
      Infiltration Cellular, Lymphocyte    | 1           1     2              1           2     1  1     1  1         |             
      Duct, Dilatation                     |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Hyperplasia, Squamous                |                      2     1           3     3                           |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Cardiomyopathy                       |       1                          2           2                           |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|             
                             DAY ON TEST   | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|             
                                           | 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
      Hypertrophy                          |                      2                                                   |             
      Infarct                              |                                                                          |             
      Pigmentation, Ceroid                 |       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     M  +  +  +     M  M  +  +  +     +     +  M     +  +  M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +  +  +     +  +  +  M  +     +     +  +     +  +  M  +   |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +  +  +     M  +  +  +  +     +     +  +     +  +  A  +   |             
      Follicle, Cyst                       |                   2                                                      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                            +                                             |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +     +  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Infiltration Cellular, Lymphocyte    |                               2                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +           +  +                 +              +     +            |             
      Inflammation, Chronic                | 2                                                                        |             
      Duct, Dilatation                     | 3     3           3  3                 3              3     3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     A  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  +  +   |             
      Atrophy                              |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Hyperplasia, Lymphoid                |       2                                      3     3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     +  +  M  +   |             
      Congestion                           | 2              2                       2     3                           |             
      Sinus, Dilatation                    |                                     4                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|             
                             DAY ON TEST   | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|             
                                           | 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                            X                                             |             
      Hyperplasia, Lymphoid                |                                              3                           |             
      Inflammation, Suppurative            |                                                                          |             
      Inflammation, Pyogranulomatous       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     A  I  +  I     +  I  +  +  +     +     +  +     +  +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M     M  M  +  M     M  M  M  M  M     M     M  M     M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Alopecia                             |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                      3                                                   |             
      Parakeratosis                        |                                                                          |             
      Sebaceous Gland, Metaplasia, Squamous|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Congestion                           |                                                             2            |             
      Hemorrhage                           |                                                    2                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Proliferative                   |                                     3                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  A  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
      Pinna, Hyperplasia, Squamous         |                                                    3                     |             
      Pinna, Inflammation, Suppurative     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 5| 6| 0| 7| 4|             
                             DAY ON TEST   | 2| 5| 2| 5| 1| 2| 2| 2| 5| 2| 1| 3| 3| 3| 5| 3| 5| 3| 3| 5| 5| 5| 1| 3| 5|             
                                           | 9| 8| 9| 8| 8| 9| 9| 2| 8| 9| 8| 0| 0| 0| 8| 0| 8| 0| 0| 6| 5| 9| 4| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    400MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +   |             
      Amyloid Deposition                   |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 2     1        1  1  1     1  1  1  3  2     2     1  1     1  1     1   |             
      Cortex, Cyst                         |                      1           1                                       |             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                      1                       1                           |             
      Renal Tubule, Hyperplasia            |                                                                3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     A  +  +  +     +  +  +  +  +     +     +  +     A  +  A  +   |             
      Infiltration Cellular, Lymphocyte    |                               2     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1|              |            |
                                           | 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
      Hyperplasia, Lymphoid                |                         3        3                 3                     |      8  2.9|
      Inflammation, Suppurative            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
      Inflammation, Suppurative            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +        +  +  +     +     +  +  +  +  +  +  +  +  +  +               |  55        |
      Basophilic Focus                     |                         4           2                                    |      5  2.4|
      Clear Cell Focus                     |                               2                                          |     14  2.0|
      Eosinophilic Focus                   |                               2           3        3  4                  |     13  2.3|
      Fatty Change                         |                                                                          |      1  2.0|
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                 2                        |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis                             |    2                                                  4                  |      3  3.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +                     |   2        |
      Fat, Inflammation, Chronic Active    |                                                    4                     |      2  3.5|
      Fat, Necrosis                        |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Atrophy                              |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                    4                     |      1  4.0|
      Polyarteritis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
      Infiltration Cellular, Lymphocyte    |                         1           1     1        1  2                  |     18  1.3|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  46        |
      Hyperplasia, Squamous                |    3                                            2                        |      9  2.2|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  43        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1|              |            |
                                           | 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Cardiomyopathy                       |                                                                          |      5  2.0|
      Inflammation, Suppurative            |                                           3                              |      1  3.0|
      Mineralization                       | 2  2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Hypertrophy                          |                                                                          |      1  2.0|
      Infarct                              |                                        3                                 |      1  3.0|
      Pigmentation, Ceroid                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Hyperplasia                          |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M           +  +     +     +  +  +  +  M  M  +  +  +  M               |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +           +  +     +     +  +  M  +  M  +  +  +  +  +               |  45        |
      Pars Distalis, Cyst                  |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                   3                    2                                 |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +                                +  +                  |  13        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Duct, Dilatation                     |                3  3                                2  3                  |     13  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  47        |
      Dilatation                           |                               3                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  48        |
      Atrophy                              |                                  3     3                                 |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1|              |            |
                                           | 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Mediastinal, Hyperplasia, Plasma Cell|                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
      Hyperplasia, Lymphoid                |                3        4                                                |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +           +  +     +     M  +  +  +  A  +  +  +  +  +               |  44        |
      Congestion                           |                                                                          |      4  2.3|
      Sinus, Dilatation                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  47        |
      Congestion                           |                                                          3               |      1  3.0|
      Developmental Malformation           |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                     2              3                     |      4  2.5|
      Inflammation, Suppurative            |                                           3                              |      1  3.0|
      Inflammation, Pyogranulomatous       |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +           +  +     I     +  +  +  I  I  +  I  I  +  +               |  39        |
      Inflammation, Suppurative            |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M           M  M     M     M  M  +  M  M  M  M  M  M  M               |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  49        |
      Alopecia                             |                               1                    3                     |      3  2.3|
      Fibrosis                             |                                                 2                        |      1  2.0|
      Inflammation, Chronic Active         |                4                                                         |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Parakeratosis                        |                                                 2                        |      1  2.0|
      Sebaceous Gland, Metaplasia, Squamous|                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |    4                                      2                              |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 9| 7| 5| 5| 5| 4| 3| 5| 2| 5| 2| 3| 3| 3| 5| 2| 2| 3| 3| 1|              |            |
                                           | 9| 9| 8| 8| 5| 0| 0| 5| 9| 8| 9| 0| 0| 9| 5| 9| 9| 0| 0| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
    400MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |    3                                                                     |      1  3.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Proliferative                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                         +                                                |   2        |
      Pinna, Hyperplasia, Squamous         |                                                                          |      1  3.0|
      Pinna, Inflammation, Suppurative     |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +  +     +     +  +  +  +  +  +  +  +  +  +               |  51        |
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Infarct                              |                                           3                              |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                 3                        |      3  2.3|
      Inflammation, Suppurative            |                                           2                              |      1  2.0|
      Nephropathy                          |    2           1  1     1     1  1  1  3     1  2  3  2                  |     45  1.4|
      Cortex, Cyst                         |                         1     2                                          |      5  1.2|
      Pelvis, Epithelium, Hyperplasia      |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Cystic    |                                              1                           |      4  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +  +     +     +  +  +  +  A  +  +  +  +  +               |  46        |
      Infiltration Cellular, Lymphocyte    |                                                       2                  |      5  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|             
                                           | 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +     +  +  +  +  M     M  +  +  +        A  I  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3                                3                     |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  A        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Basophilic Focus                     |                               2                                         2|             
      Clear Cell Focus                     |                2                                                         |             
      Eosinophilic Focus                   | 1                             2                    1                    2|             
      Fatty Change                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |       2                             3                                    |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Necrosis                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                     1                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  M        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1        1           2              1        2     1              1  1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                  2           2                           |             
      Inflammation, Suppurative            |                                  1                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|             
                                           | 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |             2                                                            |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  M        +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +     +  +  M  +  +     +  +  +  +        +  M  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Follicular Cell, Hyperplasia         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +           +                 +        +                  |             
      Inflammation, Chronic                |                                                       3                  |             
      Inflammation, Suppurative            |                            3                                             |             
      Duct, Dilatation                     |       3        3                             4                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Atrophy                              |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  M  +  +     +  +  +  +        +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Cyst                                 |                                                                          |             
      Developmental Malformation           |       X        X                                                         |             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|             
                                           | 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  +     M  M  +  M  M     M  M  M  M        M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Alopecia                             |                                              2                           |             
      Inflammation, Suppurative            |                                                                   4      |             
      Ulcer                                |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                    +                                       |             
      Hemorrhage                           |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Edema                                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Edema              |                                                                          |             
      Cornea, Edema                        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                   1                                                      |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1     1  1  1  2  1        1  1     2        2     1  1        3  1     1|             
      Cortex, Cyst                         |                            1                                             |             
      Medulla, Mineralization              |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                     1                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 4| 4| 7| 4| 7| 6| 4| 4| 5| 4| 4| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 3| 3| 3| 5| 5| 3| 2| 7| 2| 5| 5| 2| 5| 2| 3| 5| 5| 6| 1| 5| 2|             
                                           | 7| 6| 9| 9| 0| 0| 0| 6| 8| 0| 9| 7| 9| 5| 8| 9| 6| 9| 4| 8| 8| 1| 7| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1                                               2                        |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|             
                                           | 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  A  +  A  +     +     +  +  +  +  +  A  +  +  M  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Inflammation, Chronic                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  A  +  +  M  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  A  +  A  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  A  +  A  +|             
      Hyperplasia, Lymphoid                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      2                    2                              |             
      Clear Cell Focus                     |       2                                   2                              |             
      Eosinophilic Focus                   |             2                    2     3  2     2  1     2               |             
      Fatty Change                         | 1                                            2                           |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                       2                  |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                         1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   M                                                      |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Atrophy                              |                                  3                                       |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                1     1                       1  1        1               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperkeratosis                       |                         2                             3                  |             
      Hyperplasia, Squamous                |                                        3  3     3        3     1        2|             
      Inflammation, Suppurative            |                                        2  2     2        2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  A  +  +  +     +     +  +  +  +  +  A  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                2         |             
      Inflammation, Suppurative            |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|             
                                           | 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                2                                                  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  M  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                       3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +  +     M     +  +  +  +  M  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                 2        1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
      Infiltration Cellular, Lymphocyte    |                                                             1            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                +                                 |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |       3                                3                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Suppurative            |                                                       4                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Neutrophil              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  M  +  M  +     +     +  +  +  +  +  +  +  +  +  M  +  I|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +     +     I  +  +  +  +  +  +  +  +  +  M  +|             
      Congestion                           |                                                       3                  |             
      Hemorrhage                           |                         2                                      4         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
      Cyst                                 |             2                                                            |             
      Developmental Malformation           |                      X           X              X                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  M  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|             
                                           | 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M  M  M  M  +  M     M     M  M  +  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  +  +|             
      Alopecia                             |                                                                          |             
      Inflammation, Suppurative            |             3                                                            |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                           3                              |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                             +                              |             
      Cataract                             |             3                                                            |             
      Anterior Chamber, Edema              |                                           3                              |             
      Cornea, Edema                        |                                           2                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                             +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +|             
      Infarct                              |             2                                                            |             
      Inflammation, Suppurative            |                                                       3                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                2         |             
      Nephropathy                          |    1  1     1  1     1     1     1     1  1     1  1     1  1     1     1|             
      Cortex, Cyst                         |             2                                                            |             
      Medulla, Mineralization              |                      2                                                   |             
      Renal Tubule, Hyperplasia, Cystic    |                                                          1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  A  +  A  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 7| 4| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 5| 2| 2| 3| 3| 8| 2| 5| 3| 5| 3| 2| 5| 3| 3| 4| 2| 3| 5| 2| 1| 3|             
                                           | 5| 9| 9| 8| 2| 9| 8| 0| 9| 9| 8| 0| 8| 0| 9| 5| 0| 0| 5| 9| 0| 2| 9| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    800MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                   1      |             
      Inflammation, Suppurative            |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A     +  +  +  +     +     +  +  M  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A     +  M  +  +     +     +  +  +  +  +  +  +               |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M     +  +  +  +     +     +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Basophilic Focus                     |                                                                          |      4  2.0|
      Clear Cell Focus                     |       1                                3        2        2               |      7  2.0|
      Eosinophilic Focus                   |       2                                                                  |     12  1.8|
      Fatty Change                         |                                              2                           |      3  1.7|
      Hemorrhage                           |                                                    2                     |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Atrophy                              |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Infiltration Cellular, Lymphocyte    |    1  1                                                                  |     15  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Hyperkeratosis                       |                                                                          |      2  2.5|
      Hyperplasia, Squamous                |    2     2  3        2     3           1  3              4               |     16  2.4|
      Inflammation, Suppurative            |                                           2                              |      6  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  56        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Hyperplasia                          |                         1                                                |      1  1.0|
      Hypertrophy                          |                         1        2                       2               |      5  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  57        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     M  +  +  +     +     M  +  +  M  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     M  +  +  +     +     +  +  +  +  +  +  +               |  55        |
      Pars Distalis, Cyst                  |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +     +  +                 +                                 |  11        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Duct, Dilatation                     |             3     3  4                 3                                 |      9  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |                   1                                                      |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Atrophy                              |                                                 2                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M     +  +  +  +     +     +  +  +  +  +  +  +               |  54        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |       3                                                                  |      1  3.0|
      Hyperplasia, Macrophage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  57        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Cyst                                 |                                                                          |      1  2.0|
      Developmental Malformation           |                                                       X                  |      6     |
      Hyperplasia, Lymphoid                |       3                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  I     +     +  +  +  +  +  +  +               |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M     M  M  M  M     M     M  M  M  M  M  M  M               |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  A     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Alopecia                             |                                              1     2                     |      3  1.7|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Edema                                |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                              2                           |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |            |
          Squamous                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05091-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 11:27:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 3| 3| 1| 5| 2| 3| 3| 2| 5| 2| 5| 3| 3| 5| 3| 5| 2| 2|              |            |
                                           | 5| 9| 0| 0| 3| 8| 9| 0| 0| 9| 8| 9| 8| 0| 0| 6| 0| 5| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
    800MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Anterior Chamber, Edema              |                                                                          |      1  3.0|
      Cornea, Edema                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  59        |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          |    1  1  1        1  1  1  1     1     1  1     1     1  1               |     43  1.1|
      Cortex, Cyst                         |       2              2                                                   |      4  1.8|
      Medulla, Mineralization              |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +     +     +  +  +  +  +  +  +               |  58        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  1.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------