TDMS Study 05091-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DIHYDROCOUMARIN
NTP Experiment-Test: 05091-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/12/94
Route: GAVAGE Time: 08:09:01
Facility: American Biogenics Corp.
Chemical CAS #: 119-84-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 9 10 9
Early Deaths
Gavage Death 2 4 2
Moribund 13 17 20 19
Dead 4 8 4 5
Dosing Accident 1
Accident 2
Survivors
Terminal Sacrifice 31 21 26 23
Animals Examined Microscopically 60 58 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (51) (50) (59)
Inflammation, Suppurative 1 (2%)
Intestine Large, Cecum (56) (43) (47) (57)
Inflammation, Suppurative 1 (2%) 1 (2%)
Intestine Small, Duodenum (58) (45) (47) (57)
Ulcer 1 (2%)
Liver (60) (52) (52) (59)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 3 (5%) 4 (8%)
Clear Cell Focus 3 (5%) 1 (2%) 6 (12%) 8 (14%)
Congestion 1 (2%) 1 (2%)
Developmental Malformation 8 (13%) 6 (12%) 6 (12%) 4 (7%)
Eosinophilic Focus 1 (2%) 1 (2%)
Fatty Change 3 (5%) 7 (13%) 6 (12%) 1 (2%)
Inflammation, Chronic 23 (38%) 18 (35%) 20 (38%) 10 (17%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis, Coagulative 7 (13%) 4 (8%) 2 (3%)
Bile Duct, Hyperplasia 6 (10%) 5 (10%) 5 (10%) 7 (12%)
Central Vein, Dilatation 1 (2%)
Centrilobular, Necrosis, Coagulative 2 (4%) 2 (3%)
Hepatocyte, Cytoplasmic Alteration 1 (2%)
Hepatocyte, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (3%)
Periductular, Fibrosis 1 (2%) 4 (8%) 1 (2%) 2 (3%)
Periductular, Infiltration Cellular,
Lymphocyte 2 (4%)
Periductular, Inflammation, Chronic 4 (7%) 3 (5%)
Periductular, Inflammation, Suppurative 1 (2%)
Sinusoid, Dilatation 1 (2%)
Mesentery (7) (5) (4) (6)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Inflammation, Chronic 1 (14%) 2 (40%)
Fat, Inflammation, Chronic Active 1 (17%)
Fat, Necrosis, Coagulative 6 (86%) 2 (40%) 3 (75%) 3 (50%)
Fat, Necrosis, Liquifactive 1 (17%)
Pancreas (58) (46) (49) (58)
Atrophy 2 (3%) 7 (15%) 5 (10%) 5 (9%)
Ectopic Tissue 1 (2%) 1 (2%)
Hemorrhage, Chronic 1 (2%)
Hyperplasia 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 3 (7%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Interstitium, Fibrosis 2 (3%)
Salivary Glands (60) (51) (50) (59)
Periductular, Infiltration Cellular,
Lymphocyte 1 (2%)
Submandibular Gland, Inflammation, Chronic 1 (2%)
Stomach, Forestomach (60) (49) (50) (58)
Fibrosis 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%) 2 (3%)
Inflammation, Chronic 1 (2%) 2 (3%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mineralization 2 (3%) 3 (5%)
Ulcer 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (60) (48) (48) (57)
Erosion 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%) 1 (2%) 3 (5%)
Mucosa, Dilatation 1 (2%)
Tongue (2) (1)
Hyperkeratosis 1 (50%)
Hyperplasia, Squamous 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (51) (51) (59)
Cardiomyopathy 13 (22%) 16 (31%) 18 (35%) 10 (17%)
Inflammation, Suppurative 1 (2%)
Atrioventricular Valve, Fibrosis 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (51) (49) (59)
Angiectasis 1 (2%)
Clear Cell Focus 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Infarct 1 (2%)
Necrosis, Coagulative 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 1 (2%)
Adrenal Gland, Medulla (60) (51) (49) (59)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 9 (15%) 10 (20%) 8 (16%) 8 (14%)
Infiltration Cellular, Lymphocyte 1 (2%)
Islets, Pancreatic (60) (46) (50) (58)
Infiltration Cellular, Lymphocyte 1 (2%)
Necrosis, Coagulative 1 (2%)
Parathyroid Gland (51) (44) (46) (53)
Hyperplasia 2 (4%)
Pituitary Gland (59) (49) (52) (59)
Congestion 1 (2%)
Pars Distalis, Cyst 4 (7%) 6 (12%) 3 (6%) 8 (14%)
Pars Distalis, Cyst Multilocular 6 (10%) 4 (8%) 2 (4%)
Pars Distalis, Cytoplasmic Alteration 1 (2%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%)
Pars Intermedia, Hemorrhage 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (59) (48) (50) (59)
C-Cell, Hyperplasia 6 (10%) 4 (8%) 7 (14%) 2 (3%)
Follicle, Cyst 2 (3%) 1 (2%) 1 (2%)
Follicle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (57) (50) (50) (59)
Hyperplasia 2 (4%) 3 (6%) 2 (4%)
Inflammation, Suppurative 3 (5%) 4 (8%) 5 (10%) 4 (7%)
Duct, Dilatation 3 (5%) 2 (4%) 2 (4%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Duct, Inflammation, Suppurative 1 (2%)
Ovary (60) (51) (50) (59)
Follicle, Cyst 4 (7%) 4 (8%) 3 (6%) 4 (7%)
Uterus (60) (54) (55) (60)
Hemorrhage 1 (2%)
Hydrometra 5 (8%) 6 (11%) 6 (11%) 8 (13%)
Hyperplasia, Cystic 2 (4%) 6 (11%) 3 (5%)
Cervix, Inflammation, Suppurative 1 (2%) 1 (2%)
Vagina (5) (3)
Hyperkeratosis 1 (20%)
Hyperplasia, Squamous 1 (20%)
Inflammation, Suppurative 2 (40%) 3 (100%)
Metaplasia, Squamous 1 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (50) (50) (59)
Hyperplasia, Neutrophil 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (60) (51) (52) (59)
Hyperplasia, Lymphoid 1 (2%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%)
Lumbar, Hyperplasia, Histiocytic 1 (2%)
Lumbar, Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Histiocytic 1 (2%)
Mediastinal, Hyperplasia, Macrophage 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Necrosis, Coagulative 1 (2%)
Prefemoral, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mandibular (58) (51) (49) (58)
Hyperplasia, Lymphoid 2 (3%) 2 (4%) 3 (5%)
Hyperplasia, Plasma Cell 1 (2%) 2 (3%)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mesenteric (60) (50) (50) (59)
Congestion 1 (2%)
Spleen (60) (49) (49) (58)
Atrophy 1 (2%)
Congestion 1 (2%) 3 (6%) 4 (7%)
Depletion Lymphoid 1 (2%)
Developmental Malformation 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Necrosis, Liquifactive 1 (2%)
Pigmentation, Hemosiderin 2 (3%)
Capsule, Hemorrhage 1 (2%)
Thymus (53) (47) (50) (58)
Epithelial Cell, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (50) (49) (59)
Galactocele 3 (5%) 2 (4%) 3 (6%)
Lactation 1 (2%) 1 (2%) 1 (2%)
Acinus, Hyperplasia 1 (2%)
Skin (60) (51) (50) (59)
Inflammation, Suppurative 1 (2%) 1 (2%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Tail, Hyperkeratosis 1 (2%)
Tail, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (48) (58)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Hydrocephalus 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis, Liquifactive 1 (2%)
Cerebellum, Gliosis 1 (2%)
Hypothalamus, Compression 1 (2%) 3 (6%)
Meninges, Inflammation, Chronic 1 (2%)
Thalamus, Compression 2 (3%) 2 (4%) 2 (4%) 1 (2%)
Thalamus, Necrosis, Coagulative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (52) (50) (59)
Congestion 2 (4%) 1 (2%)
Edema 2 (4%) 2 (3%)
Alveolar Epithelium, Hyperplasia 3 (5%) 4 (8%) 3 (6%) 1 (2%)
Alveolus, Edema 1 (2%)
Alveolus, Foreign Body 2 (3%)
Alveolus, Hemorrhage 1 (2%)
Alveolus, Inflammation, Chronic 10 (17%) 1 (2%) 1 (2%) 1 (2%)
Alveolus, Inflammation, Suppurative 1 (2%)
Nose (60) (51) (50) (59)
Congestion 1 (2%)
Lumen, Fungus 2 (3%) 2 (4%)
Lumen, Inflammation, Chronic 1 (2%)
Lumen, Inflammation, Suppurative 3 (5%) 2 (4%) 1 (2%) 5 (8%)
Mucosa, Inflammation, Chronic Active 1 (2%)
Mucosa, Inflammation, Suppurative 1 (2%) 1 (2%) 2 (3%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (3) (2)
Iris, Synechia 1 (33%)
Lens, Cataract 1 (100%) 1 (33%) 1 (50%)
Posterior Chamber, Hemorrhage 1 (33%)
Retina, Atrophy 1 (100%)
Retina, Dysplasia 1 (33%)
Lacrimal Gland (1)
Pigmentation, Porphyrin 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (50) (50) (58)
Hydronephrosis 2 (4%)
Nephropathy 22 (37%) 21 (42%) 38 (76%) 32 (55%)
Collecting Tubule, Mineralization 1 (2%)
Cortex, Cyst 1 (2%) 1 (2%)
Cortex, Necrosis, Coagulative 1 (2%)
Interstitium, Infiltration Cellular,
Lymphocyte 2 (3%)
Pelvis, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Pelvis, Mineralization 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (58) (50) (48) (58)
Developmental Malformation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 20 10 60 60 60
Scheduled Sacrifice 9 19 10 10 10 10
Early Deaths
Moribund 12 23 26 17
Gavage Death 1 1 1 1 2
Dead 9 13 15 29
Dosing Accident 1
Survivors
Terminal Sacrifice 27 12 8 2
Moribund 1
Natural Death 1
Animals Examined Microscopically 60 20 10 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (54) (10) (44) (44) (42)
Circumanal Gland, Hyperplasia, Glandular 1 (2%)
Intestine Large, Cecum (50) (10) (42) (41) (34)
Inflammation, Suppurative 1 (3%)
Submucosa, Edema 1 (3%)
Submucosa, Inflammation, Suppurative 1 (2%)
Intestine Small, Jejunum (50) (10) (42) (43) (40)
Hemorrhage 1 (2%)
Liver (58) (20) (10) (49) (53) (60)
Angiectasis 3 (6%) 1 (2%)
Basophilic Focus 2 (3%) 1 (2%)
Clear Cell Focus 3 (5%) 1 (10%) 1 (2%) 4 (7%)
Congestion 1 (2%)
Cytologic Alterations 1 (2%)
Developmental Malformation 6 (10%) 5 (10%) 2 (4%) 5 (8%)
Fatty Change 9 (16%) 10 (50%) 1 (10%) 7 (14%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 6 (10%) 1 (10%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Coagulative 1 (5%) 4 (8%) 1 (2%) 4 (7%)
Regeneration 1 (2%)
Artery, Dilatation 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 29 (50%) 2 (10%) 4 (40%) 17 (35%) 13 (25%) 10 (17%)
Centrilobular, Inflammation, Necrotizing 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis, Coagulative 2 (3%) 1 (2%) 8 (15%) 5 (8%)
Hepatocyte, Hyperplasia 1 (2%) 3 (6%) 1 (2%)
Periductular, Fibrosis 7 (12%) 6 (12%) 9 (17%) 4 (7%)
Periductular, Infiltration Cellular,
Lymphocyte 1 (2%)
Periductular, Inflammation, Chronic 4 (7%) 1 (10%) 1 (2%) 1 (2%)
Periportal, Necrosis, Coagulative 1 (2%)
Periportal, Pigmentation, Hemosiderin 1 (2%)
Portal, Pigmentation, Hemosiderin 1 (2%)
Mesentery (19) (1) (1) (16) (11) (7)
Granuloma 1 (100%)
Fat, Inflammation, Chronic 1 (5%) 1 (100%) 1 (6%) 1 (9%)
Fat, Inflammation, Chronic Active 2 (18%)
Fat, Inflammation, Granulomatous 1 (5%)
Fat, Inflammation, Suppurative 1 (5%)
Fat, Inflammation, Fibrinopurulent 3 (19%)
Fat, Necrosis, Coagulative 13 (68%) 11 (69%) 6 (55%) 6 (86%)
Pancreas (58) (20) (10) (47) (48) (48)
Atrophy 9 (16%) 2 (10%) 4 (9%) 1 (2%) 1 (2%)
Ectopic Tissue 1 (2%)
Fibrosis 2 (20%)
Hemorrhage 1 (2%)
Hyperplasia 5 (11%) 4 (8%) 4 (8%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis, Liquifactive 1 (2%)
Polyarteritis 1 (2%)
Acinar Cell, Hyperplasia 1 (2%)
Interstitium, Infiltration Cellular,
Lymphocyte 1 (2%)
Stomach, Forestomach (56) (20) (10) (48) (50) (56)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia, Squamous 3 (5%) 11 (23%) 14 (28%) 11 (20%)
Inflammation, Chronic 3 (5%) 8 (17%) 15 (30%) 8 (14%)
Inflammation, Suppurative 1 (2%)
Ulcer 4 (7%) 14 (29%) 20 (40%) 16 (29%)
Stomach, Glandular (55) (20) (10) (47) (50) (53)
Erosion 1 (2%) 3 (6%) 4 (8%) 4 (8%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (20) (10) (50) (50) (60)
Cardiomyopathy 45 (76%) 17 (85%) 6 (60%) 33 (66%) 34 (68%) 40 (67%)
Necrosis, Zenkers 1 (2%)
Atrioventricular Valve, Fibrosis 1 (2%)
Atrioventricular Valve, Thrombosis 1 (2%)
Atrium, Inflammation, Suppurative 1 (2%)
Atrium, Thrombosis 1 (2%) 2 (4%) 2 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (20) (9) (49) (49) (60)
Basophilic Focus 1 (2%)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Vacuolization Cytoplasmic 6 (12%) 2 (4%)
Adrenal Gland, Medulla (59) (20) (9) (49) (49) (60)
Cyst 1 (2%) 1 (2%)
Hyperplasia 3 (5%) 2 (4%) 5 (10%) 2 (3%)
Inflammation, Suppurative 1 (2%)
Necrosis, Coagulative 1 (2%)
Necrosis, Liquifactive 1 (2%)
Parathyroid Gland (56) (16) (10) (41) (48) (51)
Hyperplasia 15 (37%) 26 (54%) 19 (37%)
Pituitary Gland (58) (20) (9) (48) (48) (56)
Inflammation, Suppurative 1 (2%)
Pars Distalis, Cyst 2 (3%) 4 (8%) 7 (15%) 1 (2%)
Pars Distalis, Cyst Multilocular 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage, Acute 1 (2%)
Pars Distalis, Hemorrhage, Chronic 1 (2%)
Pars Distalis, Hyperplasia 2 (3%)
Pars Distalis, Hypertrophy 2 (22%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (59) (20) (10) (48) (49) (50)
C-Cell, Hyperplasia 2 (3%) 4 (8%) 3 (6%) 3 (6%)
Follicle, Cyst 2 (4%)
Follicle, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2)
Inflammation, Suppurative 1 (50%)
Lumen, Dilatation 1 (50%)
Epididymis (58) (20) (10) (50) (48) (57)
Polyarteritis 1 (2%)
Preputial Gland (56) (2) (10) (49) (48) (59)
Hyperplasia 3 (5%) 2 (4%) 6 (13%) 2 (3%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 4 (7%) 9 (18%) 7 (15%) 7 (12%)
Duct, Dilatation 1 (2%) 2 (4%) 2 (4%) 2 (3%)
Duct, Inflammation, Suppurative 1 (2%) 1 (2%) 2 (3%)
Prostate (54) (20) (10) (48) (46) (59)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Suppurative 9 (17%) 1 (5%) 8 (17%) 12 (26%) 5 (8%)
Interstitium, Hemorrhage, Acute 1 (2%)
Seminal Vesicle (58) (20) (10) (49) (46) (59)
Inflammation, Suppurative 3 (5%) 1 (2%)
Lumen, Dilatation 1 (2%)
Testes (58) (20) (10) (52) (51) (56)
Atrophy 4 (7%) 3 (6%) 4 (8%) 3 (5%)
Degeneration 1 (5%)
Infiltration Cellular, Lymphocyte 1 (2%)
Polyarteritis 1 (2%)
Interstitial Cell, Hyperplasia 3 (5%) 11 (55%) 2 (20%) 1 (2%) 2 (4%) 4 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (56) (1) (10) (49) (50) (56)
Hypercellularity 1 (2%)
Hyperplasia, Neutrophil 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (60) (20) (10) (49) (50) (58)
Lumbar, Congestion 1 (2%)
Mediastinal, Congestion 1 (2%) 2 (3%)
Mediastinal, Inflammation, Suppurative 1 (2%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%)
Pancreatic, Hyperplasia, Plasma Cell 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (59) (20) (10) (48) (44) (52)
Congestion 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 4 (8%) 2 (4%)
Hyperplasia, Plasma Cell 2 (3%) 2 (4%) 2 (5%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mesenteric (59) (1) (10) (49) (50) (57)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Inflammation, Suppurative 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (58) (20) (10) (48) (45) (55)
Atrophy 2 (3%)
Congestion 4 (7%) 3 (6%) 2 (4%)
Congestion, Diffuse 1 (2%)
Developmental Malformation 1 (2%) 2 (4%) 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%) 1 (2%)
Hyperplasia, Macrophage 2 (4%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Necrosis, Liquifactive 2 (4%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Perivascular, Fibrosis 1 (2%)
Subcapsular, Hemorrhage 1 (2%)
Thymus (55) (1) (10) (47) (47) (55)
Congestion 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Suppurative 1 (2%)
Capsule, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (1) (8) (46) (47) (53)
Galactocele 2 (4%) 1 (2%)
Skin (60) (1) (10) (50) (48) (59)
Alopecia 1 (2%) 2 (4%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%) 1 (2%)
Subcutaneous Tissue, Developmental
Malformation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (1) (10) (50) (50) (60)
Degeneration 1 (2%)
Skeletal Muscle (1)
Metaplasia, Osseous 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57) (20) (10) (49) (46) (57)
Hemorrhage 1 (2%)
Hypothalamus, Hemorrhage, Acute 1 (2%)
Meninges, Congestion 1 (2%)
Thalamus, Compression 2 (4%)
Thalamus, Necrosis 1 (2%)
Peripheral Nerve (2) (1) (7) (3)
Degeneration, Secondary Wallerian 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (20) (10) (50) (50) (60)
Congestion 1 (5%)
Alveolar Epithelium, Hyperplasia 4 (7%) 1 (5%) 1 (10%) 3 (6%) 3 (6%) 3 (5%)
Alveolus, Congestion 1 (2%)
Alveolus, Edema 1 (2%) 2 (4%) 1 (2%)
Alveolus, Foreign Body 1 (2%)
Alveolus, Hemorrhage 2 (4%) 2 (4%) 1 (2%)
Alveolus, Inflammation, Chronic 2 (3%)
Alveolus, Inflammation, Suppurative 2 (3%) 1 (10%) 2 (4%) 2 (3%)
Bronchiole, Inflammation, Suppurative 1 (2%) 1 (2%)
Nose (59) (1) (10) (50) (48) (59)
Autolysis 1 (2%)
Fungus 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic 3 (30%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Lumen, Foreign Body 1 (2%) 2 (3%)
Lumen, Fungus 3 (5%) 3 (30%) 5 (10%) 6 (13%) 4 (7%)
Lumen, Inflammation, Suppurative 8 (14%) 8 (16%) 9 (19%) 8 (14%)
Mucosa, Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Mucosa, Septum, Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 1 (2%)
Trachea (60) (1) (10) (50) (50) (58)
Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (2)
Acanthosis 1 (100%)
Pinna, Perforation 1 (100%)
Eye (1) (1) (2) (1)
Anterior Chamber, Hemorrhage, Chronic 1 (100%)
Bilateral, Lens, Cataract 1 (50%)
Lens, Cataract 1 (50%) 1 (100%)
Retina, Degeneration 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (20) (10) (58) (57) (60)
Congestion 1 (5%)
Fibrosis 1 (2%)
Inflammation, Suppurative 1 (2%)
Nephropathy 59 (100%) 19 (95%) 10 (100%) 57 (98%) 57 (100%) 57 (95%)
Cortex, Cyst 3 (5%) 1 (2%)
Cortex, Infarct 1 (2%) 1 (2%)
Pelvis, Inflammation, Chronic 1 (2%)
Pelvis, Inflammation, Suppurative 2 (3%) 1 (2%)
Renal Tubule, Hyperplasia 3 (5%) 3 (5%)
Renal Tubule, Hyperplasia, Cystic 1 (2%) 2 (4%) 1 (2%)
Renal Tubule, Hyperplasia, Oncocytic 1 (2%) 1 (2%)
Ureter (1)
Mucosa, Inflammation, Suppurative 1 (100%)
Urinary Bladder (58) (20) (10) (48) (44) (48)
Mucosa, Inflammation, Suppurative 1 (2%) 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Submucosa, Infiltration Cellular, Lymphocyte 1 (2%)
Submucosa, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 20 10 20
Scheduled Sacrifice 19 10
Early Deaths
Gavage Death 1
Moribund 6 10
Dead 5 8
Accident 1
Survivors
Dead 1
Terminal Sacrifice 7 2
Animals Examined Microscopically 20 20 10 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (1) (13) (10) (17)
Polyarteritis 1 (8%)
Intestine Large, Rectum (1) (16) (10) (18)
Polyarteritis 1 (6%)
Intestine Small, Jejunum (1) (14) (9) (19)
Diverticulum 1 (5%)
Liver (20) (19) (10) (19)
Angiectasis 1 (5%)
Congestion 1 (5%)
Developmental Malformation 1 (5%) 1 (5%)
Ectasia 1 (5%)
Fatty Change 2 (11%) 1 (5%)
Inflammation, Suppurative 2 (11%) 1 (5%)
Necrosis, Coagulative 2 (11%)
Bile Duct, Hyperplasia 6 (30%) 2 (11%) 1 (10%) 1 (5%)
Hepatocyte, Hyperplasia 1 (5%)
Kupffer Cell, Hyperplasia 1 (5%)
Mesentery (3) (1)
Polyarteritis 1 (33%)
Fat, Necrosis, Chronic 1 (100%)
Fat, Necrosis, Coagulative 3 (100%)
Pancreas (20) (19) (10) (20)
Atrophy 1 (5%)
Fibrosis 1 (10%)
Hyperplasia 3 (15%)
Inflammation, Chronic 1 (5%)
Polyarteritis 1 (5%)
Interstitium, Infiltration Cellular,
Lymphocyte 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (20) (19) (10) (20)
Hyperplasia, Squamous 1 (5%) 2 (11%) 1 (5%)
Inflammation, Chronic 2 (11%) 4 (20%)
Ulcer 2 (11%) 4 (20%)
Stomach, Glandular (20) (18) (10) (20)
Erosion 1 (10%) 1 (5%)
Mineralization 1 (6%) 5 (25%)
Polyarteritis 1 (6%)
Ulcer 1 (5%)
Tongue (1)
Parenchyma, Edema 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (4)
Aorta, Mineralization 1 (33%) 2 (50%)
Pulmonary Artery, Mineralization 1 (25%)
Heart (20) (20) (10) (20)
Cardiomyopathy 13 (65%) 8 (40%) 8 (80%) 9 (45%)
Necrosis, Zenkers 1 (5%) 1 (5%)
Polyarteritis 1 (5%)
Artery, Mineralization 1 (5%)
Atrioventricular Valve, Fibrosis 1 (5%)
Atrium, Thrombosis 1 (5%)
Valve, Fibrosis 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (20) (20) (10) (20)
Clear Cell Focus 1 (5%)
Cytoplasmic Alteration 1 (5%)
Vacuolization Cytoplasmic 1 (5%) 1 (5%)
Adrenal Gland, Medulla (19) (20) (10) (20)
Hyperplasia 1 (5%) 1 (5%)
Infiltration Cellular, Lymphocyte 1 (10%)
Necrosis, Liquifactive 1 (5%)
Parathyroid Gland (20) (18) (10) (18)
Hyperplasia 6 (33%) 9 (50%)
Pituitary Gland (20) (18) (10) (18)
Pars Distalis, Congestion 1 (10%)
Pars Distalis, Cyst 2 (20%) 1 (6%)
Pars Distalis, Hemorrhage, Acute 1 (6%)
Thyroid Gland (20) (18) (10) (18)
Polyarteritis 1 (6%)
C-Cell, Hyperplasia 1 (6%) 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicle, Cyst 1 (6%) 1 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (1) (20) (10) (20)
Abscess 1 (5%) 1 (10%)
Hyperplasia 2 (10%)
Inflammation, Chronic 2 (20%)
Inflammation, Suppurative 1 (5%) 3 (15%)
Polyarteritis 1 (5%)
Duct, Dilatation 1 (5%)
Duct, Inflammation, Chronic 1 (5%)
Duct, Inflammation, Suppurative 1 (5%)
Prostate (20) (20) (10) (20)
Inflammation, Chronic Active 4 (20%)
Inflammation, Suppurative 3 (15%) 3 (15%)
Testes (20) (20) (10) (20)
Atrophy 1 (5%)
Interstitial Cell, Hyperplasia 9 (45%) 1 (5%) 3 (30%) 1 (5%)
Seminiferous Tubule, Degeneration 3 (15%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (20) (20) (10) (20)
Hyperplasia, Plasma Cell 1 (5%)
Mediastinal, Hemorrhage, Acute 1 (5%)
Mediastinal, Polyarteritis 1 (5%)
Renal, Congestion 1 (5%)
Renal, Hyperplasia, Macrophage 1 (5%)
Renal, Pigmentation, Hemosiderin 1 (5%)
Lymph Node, Mandibular (20) (19) (10) (18)
Angiectasis 1 (6%)
Lymph Node, Mesenteric (2) (18) (10) (20)
Angiectasis 1 (5%)
Spleen (20) (19) (10) (20)
Congestion 1 (5%)
Fibrosis 1 (5%)
Hyperplasia, Lymphoid 1 (5%)
Pigmentation, Hemosiderin 1 (5%)
Thymus (1) (18) (10) (19)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (1) (19) (9) (15)
Galactocele 1 (7%)
Lactation 1 (5%)
Skin (2) (20) (10) (20)
Cyst Epithelial Inclusion 1 (5%)
Hemorrhage 1 (5%)
Inflammation, Chronic Active 1 (5%)
Polyarteritis 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (20) (10) (20)
Degeneration, Cystic 1 (5%)
Fibrous Osteodystrophy 1 (5%)
Skeletal Muscle (1)
Polyarteritis 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (19) (10) (18)
Hydrocephalus 1 (5%)
Polyarteritis 1 (5%)
Hypothalamus, Compression 1 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (20) (20) (10) (20)
Congestion 1 (5%)
Polyarteritis 1 (5%)
Alveolar Epithelium, Hyperplasia 1 (5%)
Alveolus, Congestion 1 (5%)
Alveolus, Edema 1 (5%) 1 (5%)
Alveolus, Hemorrhage 1 (5%)
Alveolus, Inflammation, Chronic 1 (5%)
Bronchiole, Inflammation, Suppurative 1 (5%)
Nose (1) (20) (10) (18)
Inflammation, Suppurative 2 (20%)
Lumen, Fungus 1 (6%)
Lumen, Inflammation, Suppurative 1 (5%) 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mucosa, Inflammation, Suppurative 2 (11%)
Mucosa, Metaplasia, Squamous 1 (6%)
Nasolacrimal Duct, Inflammation, Chronic 1 (100%)
Submucosa, Congestion 1 (100%)
Trachea (1) (20) (10) (20)
Inflammation, Suppurative 1 (5%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Lens, Cataract 1 (100%)
Retina, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (20) (10) (20)
Nephropathy 18 (90%) 19 (95%) 10 (100%) 20 (100%)
Polyarteritis 1 (5%)
Cortex, Cyst 3 (15%)
Renal Tubule, Hyperplasia 1 (5%) 2 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
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