Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1399

TDMS Study 05091-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          DIHYDROCOUMARIN


NTP Experiment-Test: 05091-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 08:09:01




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10            9                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       2            4                         2                                     
    Moribund                                          13           17           20           19                                     
    Dead                                               4            8            4            5                                     
    Dosing Accident                                                 1                                                               
    Accident                                                                                  2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           21           26           23                                     
  Animals Examined Microscopically                    60           58           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (51)         (50)         (59)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
   Intestine Large, Cecum                             (56)         (43)         (47)         (57)                                   
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (58)         (45)         (47)         (57)                                   
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (60)         (52)         (52)         (59)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Basophilic Focus                                 3 (5%)       4 (8%)                                                          
      Clear Cell Focus                                 3 (5%)       1 (2%)       6 (12%)      8 (14%)                               
      Congestion                                                                 1 (2%)       1 (2%)                                
      Developmental Malformation                       8 (13%)      6 (12%)      6 (12%)      4 (7%)                                
      Eosinophilic Focus                                            1 (2%)                    1 (2%)                                
      Fatty Change                                     3 (5%)       7 (13%)      6 (12%)      1 (2%)                                
      Inflammation, Chronic                           23 (38%)     18 (35%)     20 (38%)     10 (17%)                               
      Mixed Cell Focus                                                           1 (2%)       1 (2%)                                
      Necrosis, Coagulative                                         7 (13%)      4 (8%)       2 (3%)                                
      Bile Duct, Hyperplasia                           6 (10%)      5 (10%)      5 (10%)      7 (12%)                               
      Central Vein, Dilatation                         1 (2%)                                                                       
      Centrilobular, Necrosis, Coagulative                          2 (4%)                    2 (3%)                                
      Hepatocyte, Cytoplasmic Alteration                                                      1 (2%)                                
      Hepatocyte, Hyperplasia                          1 (2%)       1 (2%)       2 (4%)       2 (3%)                                
      Periductular, Fibrosis                           1 (2%)       4 (8%)       1 (2%)       2 (3%)                                
      Periductular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                             2 (4%)                                             
      Periductular, Inflammation, Chronic              4 (7%)                                 3 (5%)                                
      Periductular, Inflammation, Suppurative                                                 1 (2%)                                
      Sinusoid, Dilatation                             1 (2%)                                                                       
   Mesentery                                          (7)          (5)          (4)          (6)                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Inflammation, Chronic                       1 (14%)      2 (40%)                                                         
      Fat, Inflammation, Chronic Active                                                       1 (17%)                               
      Fat, Necrosis, Coagulative                       6 (86%)      2 (40%)      3 (75%)      3 (50%)                               
      Fat, Necrosis, Liquifactive                                                             1 (17%)                               
   Pancreas                                           (58)         (46)         (49)         (58)                                   
      Atrophy                                          2 (3%)       7 (15%)      5 (10%)      5 (9%)                                
      Ectopic Tissue                                                1 (2%)       1 (2%)                                             
      Hemorrhage, Chronic                                           1 (2%)                                                          
      Hyperplasia                                                   2 (4%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic                                         3 (7%)                    1 (2%)                                
      Necrosis, Coagulative                                         1 (2%)                                                          
      Interstitium, Fibrosis                                                                  2 (3%)                                
   Salivary Glands                                    (60)         (51)         (50)         (59)                                   
      Periductular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   1 (2%)                                                                       
      Submandibular Gland, Inflammation, Chronic       1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (49)         (50)         (58)                                   
      Fibrosis                                                                                1 (2%)                                
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Squamous                            1 (2%)                    1 (2%)       2 (3%)                                
      Inflammation, Chronic                            1 (2%)                                 2 (3%)                                
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Mineralization                                   2 (3%)                                 3 (5%)                                
      Ulcer                                            3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (60)         (48)         (48)         (57)                                   
      Erosion                                                                    1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Ulcer                                            1 (2%)       1 (2%)                    3 (5%)                                
      Mucosa, Dilatation                                                         1 (2%)                                             
   Tongue                                                          (2)          (1)                                                 
      Hyperkeratosis                                                1 (50%)                                                         
      Hyperplasia, Squamous                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (51)         (51)         (59)                                   
      Cardiomyopathy                                  13 (22%)     16 (31%)     18 (35%)     10 (17%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
      Atrioventricular Valve, Fibrosis                                           1 (2%)                                             
      Atrium, Thrombosis                                                         1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (51)         (49)         (59)                                   
      Angiectasis                                                                1 (2%)                                             
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion                                                                              1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Necrosis, Coagulative                                         1 (2%)                                                          
      Vacuolization Cytoplasmic                                     4 (8%)                    1 (2%)                                
   Adrenal Gland, Medulla                             (60)         (51)         (49)         (59)                                   
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                      9 (15%)     10 (20%)      8 (16%)      8 (14%)                               
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (46)         (50)         (58)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                                                          
   Parathyroid Gland                                  (51)         (44)         (46)         (53)                                   
      Hyperplasia                                                                             2 (4%)                                
   Pituitary Gland                                    (59)         (49)         (52)         (59)                                   
      Congestion                                                                              1 (2%)                                
      Pars Distalis, Cyst                              4 (7%)       6 (12%)      3 (6%)       8 (14%)                               
      Pars Distalis, Cyst Multilocular                 6 (10%)      4 (8%)       2 (4%)                                             
      Pars Distalis, Cytoplasmic Alteration                         1 (2%)                                                          
      Pars Distalis, Hemorrhage                                     1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia                       1 (2%)                                 1 (2%)                                
      Pars Distalis, Pigmentation, Hemosiderin                                   1 (2%)                                             
      Pars Intermedia, Hemorrhage                                                1 (2%)                                             
      Pars Nervosa, Cyst                               1 (2%)                                                                       
   Thyroid Gland                                      (59)         (48)         (50)         (59)                                   
      C-Cell, Hyperplasia                              6 (10%)      4 (8%)       7 (14%)      2 (3%)                                
      Follicle, Cyst                                   2 (3%)                    1 (2%)       1 (2%)                                
      Follicle, Dilatation                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (50)         (50)         (59)                                   
      Hyperplasia                                      2 (4%)       3 (6%)       2 (4%)                                             
      Inflammation, Suppurative                        3 (5%)       4 (8%)       5 (10%)      4 (7%)                                
      Duct, Dilatation                                 3 (5%)       2 (4%)       2 (4%)       2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Duct, Inflammation, Suppurative                                            1 (2%)                                             
   Ovary                                              (60)         (51)         (50)         (59)                                   
      Follicle, Cyst                                   4 (7%)       4 (8%)       3 (6%)       4 (7%)                                
   Uterus                                             (60)         (54)         (55)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hydrometra                                       5 (8%)       6 (11%)      6 (11%)      8 (13%)                               
      Hyperplasia, Cystic                                           2 (4%)       6 (11%)      3 (5%)                                
      Cervix, Inflammation, Suppurative                                          1 (2%)       1 (2%)                                
   Vagina                                                          (5)                       (3)                                    
      Hyperkeratosis                                                1 (20%)                                                         
      Hyperplasia, Squamous                                         1 (20%)                                                         
      Inflammation, Suppurative                                     2 (40%)                   3 (100%)                              
      Metaplasia, Squamous                                          1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (50)         (59)                                   
      Hyperplasia, Neutrophil                                       1 (2%)                                                          
      Myelofibrosis                                                                           1 (2%)                                
   Lymph Node                                         (60)         (51)         (52)         (59)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inguinal, Hyperplasia, Plasma Cell                            1 (2%)                                                          
      Lumbar, Hyperplasia, Histiocytic                                                        1 (2%)                                
      Lumbar, Pigmentation, Hemosiderin                                          1 (2%)                                             
      Mediastinal, Congestion                                                                 1 (2%)                                
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
      Mediastinal, Hyperplasia, Histiocytic                                                   1 (2%)                                
      Mediastinal, Hyperplasia, Macrophage                                       1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                                                   1 (2%)                                
      Mediastinal, Necrosis, Coagulative                            1 (2%)                                                          
      Prefemoral, Hyperplasia, Lymphoid                1 (2%)                    1 (2%)                                             
   Lymph Node, Mandibular                             (58)         (51)         (49)         (58)                                   
      Hyperplasia, Lymphoid                            2 (3%)       2 (4%)                    3 (5%)                                
      Hyperplasia, Plasma Cell                                      1 (2%)                    2 (3%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (60)         (50)         (50)         (59)                                   
      Congestion                                                                 1 (2%)                                             
   Spleen                                             (60)         (49)         (49)         (58)                                   
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                    3 (6%)       4 (7%)                                
      Depletion Lymphoid                               1 (2%)                                                                       
      Developmental Malformation                                                              1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Hyperplasia, Lymphoid                                         2 (4%)       1 (2%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Reticulum Cell                                   1 (2%)                    1 (2%)                                
      Necrosis, Coagulative                                         1 (2%)                                                          
      Necrosis, Liquifactive                           1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                               2 (3%)                                
      Capsule, Hemorrhage                                           1 (2%)                                                          
   Thymus                                             (53)         (47)         (50)         (58)                                   
      Epithelial Cell, Cyst                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (50)         (49)         (59)                                   
      Galactocele                                      3 (5%)       2 (4%)       3 (6%)                                             
      Lactation                                        1 (2%)       1 (2%)       1 (2%)                                             
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Skin                                               (60)         (51)         (50)         (59)                                   
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
          Inclusion                                                                           1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
      Tail, Hyperkeratosis                                                                    1 (2%)                                
      Tail, Inflammation, Suppurative                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (48)         (58)                                   
      Hemorrhage                                       1 (2%)       2 (4%)                    1 (2%)                                
      Hydrocephalus                                    1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Necrosis, Liquifactive                                        1 (2%)                                                          
      Cerebellum, Gliosis                                                                     1 (2%)                                
      Hypothalamus, Compression                        1 (2%)                    3 (6%)                                             
      Meninges, Inflammation, Chronic                  1 (2%)                                                                       
      Thalamus, Compression                            2 (3%)       2 (4%)       2 (4%)       1 (2%)                                
      Thalamus, Necrosis, Coagulative                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (50)         (59)                                   
      Congestion                                                    2 (4%)                    1 (2%)                                
      Edema                                                         2 (4%)                    2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 3 (5%)       4 (8%)       3 (6%)       1 (2%)                                
      Alveolus, Edema                                  1 (2%)                                                                       
      Alveolus, Foreign Body                                                                  2 (3%)                                
      Alveolus, Hemorrhage                             1 (2%)                                                                       
      Alveolus, Inflammation, Chronic                 10 (17%)      1 (2%)       1 (2%)       1 (2%)                                
      Alveolus, Inflammation, Suppurative                           1 (2%)                                                          
   Nose                                               (60)         (51)         (50)         (59)                                   
      Congestion                                                                              1 (2%)                                
      Lumen, Fungus                                    2 (3%)                    2 (4%)                                             
      Lumen, Inflammation, Chronic                     1 (2%)                                                                       
      Lumen, Inflammation, Suppurative                 3 (5%)       2 (4%)       1 (2%)       5 (8%)                                
      Mucosa, Inflammation, Chronic Active             1 (2%)                                                                       
      Mucosa, Inflammation, Suppurative                1 (2%)                    1 (2%)       2 (3%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (3)          (2)                                    
      Iris, Synechia                                                             1 (33%)                                            
      Lens, Cataract                                   1 (100%)                  1 (33%)      1 (50%)                               
      Posterior Chamber, Hemorrhage                                              1 (33%)                                            
      Retina, Atrophy                                  1 (100%)                                                                     
      Retina, Dysplasia                                                          1 (33%)                                            
   Lacrimal Gland                                                  (1)                                                              
      Pigmentation, Porphyrin                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (50)         (58)                                   
      Hydronephrosis                                                2 (4%)                                                          
      Nephropathy                                     22 (37%)     21 (42%)     38 (76%)     32 (55%)                               
      Collecting Tubule, Mineralization                1 (2%)                                                                       
      Cortex, Cyst                                     1 (2%)                    1 (2%)                                             
      Cortex, Necrosis, Coagulative                    1 (2%)                                                                       
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                   2 (3%)                                                                       
      Pelvis, Inflammation, Chronic                                 1 (2%)       1 (2%)       1 (2%)                                
      Pelvis, Mineralization                                        1 (2%)                                                          
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
   Urinary Bladder                                    (58)         (50)         (48)         (58)                                   
      Developmental Malformation                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           20           10           60           60           60           
  Scheduled Sacrifice                                  9           19           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund                                          12                                     23           26           17           
    Gavage Death                                       1            1                         1            1            2           
    Dead                                               9                                     13           15           29           
    Dosing Accident                                    1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                27                                     12            8            2           
    Moribund                                                                                  1                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    60           20           10           60           60           60           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (54)                      (10)         (44)         (44)         (42)         
      Circumanal Gland, Hyperplasia, Glandular                                                1 (2%)                                
   Intestine Large, Cecum                             (50)                      (10)         (42)         (41)         (34)         
      Inflammation, Suppurative                                                                                         1 (3%)      
      Submucosa, Edema                                                                                                  1 (3%)      
      Submucosa, Inflammation, Suppurative                                                                 1 (2%)                   
   Intestine Small, Jejunum                           (50)                      (10)         (42)         (43)         (40)         
      Hemorrhage                                                                                           1 (2%)                   
   Liver                                              (58)         (20)         (10)         (49)         (53)         (60)         
      Angiectasis                                                                             3 (6%)       1 (2%)                   
      Basophilic Focus                                 2 (3%)                                 1 (2%)                                
      Clear Cell Focus                                 3 (5%)                    1 (10%)                   1 (2%)       4 (7%)      
      Congestion                                       1 (2%)                                                                       
      Cytologic Alterations                            1 (2%)                                                                       
      Developmental Malformation                       6 (10%)                                5 (10%)      2 (4%)       5 (8%)      
      Fatty Change                                     9 (16%)     10 (50%)      1 (10%)      7 (14%)                               
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Inflammation, Chronic                            6 (10%)                   1 (10%)                                1 (2%)      
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Necrotizing                                                                            1 (2%)                   
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)                                
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Coagulative                                         1 (5%)                    4 (8%)       1 (2%)       4 (7%)      
      Regeneration                                                                                                      1 (2%)      
      Artery, Dilatation                                                                                                1 (2%)      
      Bile Duct, Cyst                                                                                                   1 (2%)      
      Bile Duct, Hyperplasia                          29 (50%)      2 (10%)      4 (40%)     17 (35%)     13 (25%)     10 (17%)     
      Centrilobular, Inflammation, Necrotizing                                                                          1 (2%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis, Coagulative             2 (3%)                                 1 (2%)       8 (15%)      5 (8%)      
      Hepatocyte, Hyperplasia                                                                 1 (2%)       3 (6%)       1 (2%)      
      Periductular, Fibrosis                           7 (12%)                                6 (12%)      9 (17%)      4 (7%)      
      Periductular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                                          1 (2%)                                
      Periductular, Inflammation, Chronic              4 (7%)                    1 (10%)      1 (2%)                    1 (2%)      
      Periportal, Necrosis, Coagulative                1 (2%)                                                                       
      Periportal, Pigmentation, Hemosiderin            1 (2%)                                                                       
      Portal, Pigmentation, Hemosiderin                1 (2%)                                                                       
   Mesentery                                          (19)         (1)          (1)          (16)         (11)         (7)          
      Granuloma                                                     1 (100%)                                                        
      Fat, Inflammation, Chronic                       1 (5%)                    1 (100%)     1 (6%)       1 (9%)                   
      Fat, Inflammation, Chronic Active                                                                    2 (18%)                  
      Fat, Inflammation, Granulomatous                 1 (5%)                                                                       
      Fat, Inflammation, Suppurative                   1 (5%)                                                                       
      Fat, Inflammation, Fibrinopurulent                                                      3 (19%)                               
      Fat, Necrosis, Coagulative                      13 (68%)                               11 (69%)      6 (55%)      6 (86%)     
   Pancreas                                           (58)         (20)         (10)         (47)         (48)         (48)         
      Atrophy                                          9 (16%)      2 (10%)                   4 (9%)       1 (2%)       1 (2%)      
      Ectopic Tissue                                                                          1 (2%)                                
      Fibrosis                                                                   2 (20%)                                            
      Hemorrhage                                                                                           1 (2%)                   
      Hyperplasia                                                                             5 (11%)      4 (8%)       4 (8%)      
      Inflammation, Chronic                            1 (2%)                                              1 (2%)       1 (2%)      
      Inflammation, Necrotizing                                                               1 (2%)                                
      Inflammation, Suppurative                                                                                         1 (2%)      
      Necrosis, Liquifactive                                                                                            1 (2%)      
      Polyarteritis                                                                                        1 (2%)                   
      Acinar Cell, Hyperplasia                         1 (2%)                                                                       
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                                                                                    1 (2%)      
   Stomach, Forestomach                               (56)         (20)         (10)         (48)         (50)         (56)         
      Cyst Epithelial Inclusion                        1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                                           1 (2%)                   
      Hyperkeratosis                                                                                       1 (2%)       1 (2%)      
      Hyperplasia, Squamous                            3 (5%)                                11 (23%)     14 (28%)     11 (20%)     
      Inflammation, Chronic                            3 (5%)                                 8 (17%)     15 (30%)      8 (14%)     
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            4 (7%)                                14 (29%)     20 (40%)     16 (29%)     
   Stomach, Glandular                                 (55)         (20)         (10)         (47)         (50)         (53)         
      Erosion                                          1 (2%)                                 3 (6%)       4 (8%)       4 (8%)      
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 2 (4%)       1 (2%)       1 (2%)      
      Mineralization                                                                          1 (2%)                                
      Ulcer                                                                                   1 (2%)       1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (20)         (10)         (50)         (50)         (60)         
      Cardiomyopathy                                  45 (76%)     17 (85%)      6 (60%)     33 (66%)     34 (68%)     40 (67%)     
      Necrosis, Zenkers                                                                                    1 (2%)                   
      Atrioventricular Valve, Fibrosis                                                                                  1 (2%)      
      Atrioventricular Valve, Thrombosis                                                                   1 (2%)                   
      Atrium, Inflammation, Suppurative                                                                                 1 (2%)      
      Atrium, Thrombosis                                                                      1 (2%)       2 (4%)       2 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (20)         (9)          (49)         (49)         (60)         
      Basophilic Focus                                 1 (2%)                                                                       
      Cytoplasmic Alteration                                                                  1 (2%)                    1 (2%)      
      Hemorrhage                                                                              1 (2%)                                
      Vacuolization Cytoplasmic                                                               6 (12%)      2 (4%)                   
   Adrenal Gland, Medulla                             (59)         (20)         (9)          (49)         (49)         (60)         
      Cyst                                             1 (2%)                                 1 (2%)                                
      Hyperplasia                                      3 (5%)                                 2 (4%)       5 (10%)      2 (3%)      
      Inflammation, Suppurative                                                                                         1 (2%)      
      Necrosis, Coagulative                            1 (2%)                                                                       
      Necrosis, Liquifactive                                                                  1 (2%)                                
   Parathyroid Gland                                  (56)         (16)         (10)         (41)         (48)         (51)         
      Hyperplasia                                                                            15 (37%)     26 (54%)     19 (37%)     
   Pituitary Gland                                    (58)         (20)         (9)          (48)         (48)         (56)         
      Inflammation, Suppurative                                                               1 (2%)                                
      Pars Distalis, Cyst                              2 (3%)                                 4 (8%)       7 (15%)      1 (2%)      
      Pars Distalis, Cyst Multilocular                 1 (2%)                                 1 (2%)       1 (2%)       1 (2%)      
      Pars Distalis, Hemorrhage, Acute                                                                     1 (2%)                   
      Pars Distalis, Hemorrhage, Chronic                                                      1 (2%)                                
      Pars Distalis, Hyperplasia                       2 (3%)                                                                       
      Pars Distalis, Hypertrophy                                                 2 (22%)                                            
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (59)         (20)         (10)         (48)         (49)         (50)         
      C-Cell, Hyperplasia                              2 (3%)                                 4 (8%)       3 (6%)       3 (6%)      
      Follicle, Cyst                                                                                                    2 (4%)      
      Follicle, Hyperplasia                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)          (1)          (1)          
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)                                                                           
      Inflammation, Suppurative                        1 (50%)                                                                      
      Lumen, Dilatation                                1 (50%)                                                                      
   Epididymis                                         (58)         (20)         (10)         (50)         (48)         (57)         
      Polyarteritis                                                                           1 (2%)                                
   Preputial Gland                                    (56)         (2)          (10)         (49)         (48)         (59)         
      Hyperplasia                                      3 (5%)                                 2 (4%)       6 (13%)      2 (3%)      
      Inflammation, Chronic                            1 (2%)                                 1 (2%)       1 (2%)       2 (3%)      
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                        4 (7%)                                 9 (18%)      7 (15%)      7 (12%)     
      Duct, Dilatation                                 1 (2%)                                 2 (4%)       2 (4%)       2 (3%)      
      Duct, Inflammation, Suppurative                                                         1 (2%)       1 (2%)       2 (3%)      
   Prostate                                           (54)         (20)         (10)         (48)         (46)         (59)         
      Hyperplasia                                      1 (2%)                                              1 (2%)                   
      Inflammation, Suppurative                        9 (17%)      1 (5%)                    8 (17%)     12 (26%)      5 (8%)      
      Interstitium, Hemorrhage, Acute                                                                                   1 (2%)      
   Seminal Vesicle                                    (58)         (20)         (10)         (49)         (46)         (59)         
      Inflammation, Suppurative                        3 (5%)                                                           1 (2%)      
      Lumen, Dilatation                                1 (2%)                                                                       
   Testes                                             (58)         (20)         (10)         (52)         (51)         (56)         
      Atrophy                                          4 (7%)                                 3 (6%)       4 (8%)       3 (5%)      
      Degeneration                                                  1 (5%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Polyarteritis                                                                           1 (2%)                                
      Interstitial Cell, Hyperplasia                   3 (5%)      11 (55%)      2 (20%)      1 (2%)       2 (4%)       4 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (56)         (1)          (10)         (49)         (50)         (56)         
      Hypercellularity                                                                        1 (2%)                                
      Hyperplasia, Neutrophil                                                                              1 (2%)                   
      Myelofibrosis                                                                                        1 (2%)                   
   Lymph Node                                         (60)         (20)         (10)         (49)         (50)         (58)         
      Lumbar, Congestion                                                                                   1 (2%)                   
      Mediastinal, Congestion                                                                              1 (2%)       2 (3%)      
      Mediastinal, Inflammation, Suppurative                                                               1 (2%)                   
      Mediastinal, Pigmentation, Hemosiderin                                                               1 (2%)                   
      Pancreatic, Hyperplasia, Plasma Cell                                                                 1 (2%)                   
      Renal, Hyperplasia, Plasma Cell                                                         1 (2%)                                
   Lymph Node, Mandibular                             (59)         (20)         (10)         (48)         (44)         (52)         
      Congestion                                                                                                        1 (2%)      
      Hyperplasia, Lymphoid                            2 (3%)                                 4 (8%)                    2 (4%)      
      Hyperplasia, Plasma Cell                         2 (3%)                                 2 (4%)       2 (5%)       1 (2%)      
      Inflammation, Suppurative                                                                            1 (2%)                   
   Lymph Node, Mesenteric                             (59)         (1)          (10)         (49)         (50)         (57)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                                                           1 (2%)                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                                                                   2 (4%)                                
      Inflammation, Suppurative                                                                            1 (2%)                   
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spleen                                             (58)         (20)         (10)         (48)         (45)         (55)         
      Atrophy                                          2 (3%)                                                                       
      Congestion                                       4 (7%)                                 3 (6%)       2 (4%)                   
      Congestion, Diffuse                                                                                  1 (2%)                   
      Developmental Malformation                       1 (2%)                                 2 (4%)       1 (2%)                   
      Fibrosis                                                                                1 (2%)                    1 (2%)      
      Hyperplasia, Lymphoid                            1 (2%)                                 3 (6%)       1 (2%)                   
      Hyperplasia, Macrophage                                                                              2 (4%)                   
      Infiltration Cellular, Mononuclear Cell                                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)       1 (2%)                   
      Necrosis, Liquifactive                                                                                            2 (4%)      
      Pigmentation, Hemosiderin                                                               1 (2%)                    1 (2%)      
      Perivascular, Fibrosis                                                                  1 (2%)                                
      Subcapsular, Hemorrhage                                                                                           1 (2%)      
   Thymus                                             (55)         (1)          (10)         (47)         (47)         (55)         
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                                                              1 (2%)                    1 (2%)      
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
      Inflammation, Suppurative                                                                            1 (2%)                   
      Capsule, Inflammation, Suppurative                                                                                1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (1)          (8)          (46)         (47)         (53)         
      Galactocele                                                                             2 (4%)       1 (2%)                   
   Skin                                               (60)         (1)          (10)         (50)         (48)         (59)         
      Alopecia                                                                                1 (2%)       2 (4%)       1 (2%)      
      Cyst Epithelial Inclusion                        1 (2%)                                              1 (2%)       1 (2%)      
      Hyperkeratosis                                                                                       1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                                           1 (2%)      
      Inflammation, Suppurative                                                                            1 (2%)                   
      Ulcer                                            1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Developmental                                                                                            
          Malformation                                                                                     1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (1)          (10)         (50)         (50)         (60)         
      Degeneration                                     1 (2%)                                                                       
   Skeletal Muscle                                                                           (1)                                    
      Metaplasia, Osseous                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)         (20)         (10)         (49)         (46)         (57)         
      Hemorrhage                                                                              1 (2%)                                
      Hypothalamus, Hemorrhage, Acute                                                                      1 (2%)                   
      Meninges, Congestion                                                                    1 (2%)                                
      Thalamus, Compression                            2 (4%)                                                                       
      Thalamus, Necrosis                                                                                                1 (2%)      
   Peripheral Nerve                                   (2)                                    (1)          (7)          (3)          
      Degeneration, Secondary Wallerian                1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (20)         (10)         (50)         (50)         (60)         
      Congestion                                                    1 (5%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (7%)       1 (5%)       1 (10%)      3 (6%)       3 (6%)       3 (5%)      
      Alveolus, Congestion                                                                                              1 (2%)      
      Alveolus, Edema                                  1 (2%)                                 2 (4%)                    1 (2%)      
      Alveolus, Foreign Body                                                                                            1 (2%)      
      Alveolus, Hemorrhage                                                                    2 (4%)       2 (4%)       1 (2%)      
      Alveolus, Inflammation, Chronic                  2 (3%)                                                                       
      Alveolus, Inflammation, Suppurative              2 (3%)                    1 (10%)      2 (4%)                    2 (3%)      
      Bronchiole, Inflammation, Suppurative            1 (2%)                                                           1 (2%)      
   Nose                                               (59)         (1)          (10)         (50)         (48)         (59)         
      Autolysis                                                                                            1 (2%)                   
      Fungus                                           1 (2%)                                              2 (4%)       1 (2%)      
      Inflammation, Chronic                                                      3 (30%)                   1 (2%)                   
      Metaplasia, Squamous                             1 (2%)                                                                       
      Lumen, Foreign Body                              1 (2%)                                                           2 (3%)      
      Lumen, Fungus                                    3 (5%)                    3 (30%)      5 (10%)      6 (13%)      4 (7%)      
      Lumen, Inflammation, Suppurative                 8 (14%)                                8 (16%)      9 (19%)      8 (14%)     
      Mucosa, Inflammation, Suppurative                1 (2%)                                 2 (4%)       2 (4%)       1 (2%)      
      Mucosa, Septum, Inflammation, Chronic            1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative                                                         2 (4%)       1 (2%)      
   Trachea                                            (60)         (1)          (10)         (50)         (50)         (58)         
      Inflammation, Suppurative                                                               2 (4%)       1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)          (1)          (2)          
      Acanthosis                                                                                           1 (100%)                 
      Pinna, Perforation                                                                      1 (100%)                              
   Eye                                                (1)          (1)                       (2)                       (1)          
      Anterior Chamber, Hemorrhage, Chronic            1 (100%)                                                                     
      Bilateral, Lens, Cataract                                                               1 (50%)                               
      Lens, Cataract                                                                          1 (50%)                   1 (100%)    
      Retina, Degeneration                                                                    1 (50%)                   1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (20)         (10)         (58)         (57)         (60)         
      Congestion                                                    1 (5%)                                                          
      Fibrosis                                                                                                          1 (2%)      
      Inflammation, Suppurative                                                                                         1 (2%)      
      Nephropathy                                     59 (100%)    19 (95%)     10 (100%)    57 (98%)     57 (100%)    57 (95%)     
      Cortex, Cyst                                     3 (5%)                                                           1 (2%)      
      Cortex, Infarct                                                                                      1 (2%)       1 (2%)      
      Pelvis, Inflammation, Chronic                                                                                     1 (2%)      
      Pelvis, Inflammation, Suppurative                2 (3%)                                                           1 (2%)      
      Renal Tubule, Hyperplasia                                                               3 (5%)                    3 (5%)      
      Renal Tubule, Hyperplasia, Cystic                1 (2%)                                              2 (4%)       1 (2%)      
      Renal Tubule, Hyperplasia, Oncocytic             1 (2%)                                              1 (2%)                   
   Ureter                                             (1)                                                                           
      Mucosa, Inflammation, Suppurative                1 (100%)                                                                     
   Urinary Bladder                                    (58)         (20)         (10)         (48)         (44)         (48)         
      Mucosa, Inflammation, Suppurative                1 (2%)                                 1 (2%)                                
      Serosa, Inflammation, Suppurative                                                       1 (2%)                                
      Submucosa, Infiltration Cellular, Lymphocyte                                                         1 (2%)                   
      Submucosa, Inflammation, Suppurative             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          20           20           10           20                                     
  Scheduled Sacrifice                                 19                        10                                                  
  Early Deaths                                                                                                                      
    Gavage Death                                       1                                                                            
    Moribund                                                        6                        10                                     
    Dead                                                            5                         8                                     
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Dead                                                            1                                                               
    Terminal Sacrifice                                              7                         2                                     
  Animals Examined Microscopically                    20           20           10           20                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (1)          (13)         (10)         (17)                                   
      Polyarteritis                                                 1 (8%)                                                          
   Intestine Large, Rectum                            (1)          (16)         (10)         (18)                                   
      Polyarteritis                                                 1 (6%)                                                          
   Intestine Small, Jejunum                           (1)          (14)         (9)          (19)                                   
      Diverticulum                                                                            1 (5%)                                
   Liver                                              (20)         (19)         (10)         (19)                                   
      Angiectasis                                                                             1 (5%)                                
      Congestion                                       1 (5%)                                                                       
      Developmental Malformation                       1 (5%)                                 1 (5%)                                
      Ectasia                                                                                 1 (5%)                                
      Fatty Change                                                  2 (11%)                   1 (5%)                                
      Inflammation, Suppurative                                     2 (11%)                   1 (5%)                                
      Necrosis, Coagulative                                         2 (11%)                                                         
      Bile Duct, Hyperplasia                           6 (30%)      2 (11%)      1 (10%)      1 (5%)                                
      Hepatocyte, Hyperplasia                                       1 (5%)                                                          
      Kupffer Cell, Hyperplasia                        1 (5%)                                                                       
   Mesentery                                                       (3)          (1)                                                 
      Polyarteritis                                                 1 (33%)                                                         
      Fat, Necrosis, Chronic                                                     1 (100%)                                           
      Fat, Necrosis, Coagulative                                    3 (100%)                                                        
   Pancreas                                           (20)         (19)         (10)         (20)                                   
      Atrophy                                                                                 1 (5%)                                
      Fibrosis                                                                   1 (10%)                                            
      Hyperplasia                                                                             3 (15%)                               
      Inflammation, Chronic                            1 (5%)                                                                       
      Polyarteritis                                                 1 (5%)                                                          
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                                             1 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (20)         (19)         (10)         (20)                                   
      Hyperplasia, Squamous                            1 (5%)       2 (11%)                   1 (5%)                                
      Inflammation, Chronic                                         2 (11%)                   4 (20%)                               
      Ulcer                                                         2 (11%)                   4 (20%)                               
   Stomach, Glandular                                 (20)         (18)         (10)         (20)                                   
      Erosion                                                                    1 (10%)      1 (5%)                                
      Mineralization                                                1 (6%)                    5 (25%)                               
      Polyarteritis                                                 1 (6%)                                                          
      Ulcer                                                                                   1 (5%)                                
   Tongue                                                          (1)                                                              
      Parenchyma, Edema                                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (3)                       (4)                                    
      Aorta, Mineralization                                         1 (33%)                   2 (50%)                               
      Pulmonary Artery, Mineralization                                                        1 (25%)                               
   Heart                                              (20)         (20)         (10)         (20)                                   
      Cardiomyopathy                                  13 (65%)      8 (40%)      8 (80%)      9 (45%)                               
      Necrosis, Zenkers                                             1 (5%)                    1 (5%)                                
      Polyarteritis                                                 1 (5%)                                                          
      Artery, Mineralization                                                                  1 (5%)                                
      Atrioventricular Valve, Fibrosis                              1 (5%)                                                          
      Atrium, Thrombosis                                            1 (5%)                                                          
      Valve, Fibrosis                                               1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (20)         (10)         (20)                                   
      Clear Cell Focus                                              1 (5%)                                                          
      Cytoplasmic Alteration                                        1 (5%)                                                          
      Vacuolization Cytoplasmic                                     1 (5%)                    1 (5%)                                
   Adrenal Gland, Medulla                             (19)         (20)         (10)         (20)                                   
      Hyperplasia                                                   1 (5%)                    1 (5%)                                
      Infiltration Cellular, Lymphocyte                                          1 (10%)                                            
      Necrosis, Liquifactive                                                                  1 (5%)                                
   Parathyroid Gland                                  (20)         (18)         (10)         (18)                                   
      Hyperplasia                                                   6 (33%)                   9 (50%)                               
   Pituitary Gland                                    (20)         (18)         (10)         (18)                                   
      Pars Distalis, Congestion                                                  1 (10%)                                            
      Pars Distalis, Cyst                                                        2 (20%)      1 (6%)                                
      Pars Distalis, Hemorrhage, Acute                                                        1 (6%)                                
   Thyroid Gland                                      (20)         (18)         (10)         (18)                                   
      Polyarteritis                                                 1 (6%)                                                          
      C-Cell, Hyperplasia                                           1 (6%)                    1 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Cyst                                                1 (6%)                    1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (1)          (20)         (10)         (20)                                   
      Abscess                                                       1 (5%)       1 (10%)                                            
      Hyperplasia                                                                             2 (10%)                               
      Inflammation, Chronic                                                      2 (20%)                                            
      Inflammation, Suppurative                                     1 (5%)                    3 (15%)                               
      Polyarteritis                                                 1 (5%)                                                          
      Duct, Dilatation                                              1 (5%)                                                          
      Duct, Inflammation, Chronic                                                             1 (5%)                                
      Duct, Inflammation, Suppurative                                                         1 (5%)                                
   Prostate                                           (20)         (20)         (10)         (20)                                   
      Inflammation, Chronic Active                     4 (20%)                                                                      
      Inflammation, Suppurative                                     3 (15%)                   3 (15%)                               
   Testes                                             (20)         (20)         (10)         (20)                                   
      Atrophy                                                                                 1 (5%)                                
      Interstitial Cell, Hyperplasia                   9 (45%)      1 (5%)       3 (30%)      1 (5%)                                
      Seminiferous Tubule, Degeneration                3 (15%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (20)         (20)         (10)         (20)                                   
      Hyperplasia, Plasma Cell                                      1 (5%)                                                          
      Mediastinal, Hemorrhage, Acute                                                          1 (5%)                                
      Mediastinal, Polyarteritis                                    1 (5%)                                                          
      Renal, Congestion                                                                       1 (5%)                                
      Renal, Hyperplasia, Macrophage                                1 (5%)                                                          
      Renal, Pigmentation, Hemosiderin                              1 (5%)                                                          
   Lymph Node, Mandibular                             (20)         (19)         (10)         (18)                                   
      Angiectasis                                                                             1 (6%)                                
   Lymph Node, Mesenteric                             (2)          (18)         (10)         (20)                                   
      Angiectasis                                                                             1 (5%)                                
   Spleen                                             (20)         (19)         (10)         (20)                                   
      Congestion                                                    1 (5%)                                                          
      Fibrosis                                                                                1 (5%)                                
      Hyperplasia, Lymphoid                                         1 (5%)                                                          
      Pigmentation, Hemosiderin                                     1 (5%)                                                          
   Thymus                                             (1)          (18)         (10)         (19)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                                    1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)          (19)         (9)          (15)                                   
      Galactocele                                                                             1 (7%)                                
      Lactation                                                     1 (5%)                                                          
   Skin                                               (2)          (20)         (10)         (20)                                   
      Cyst Epithelial Inclusion                                                               1 (5%)                                
      Hemorrhage                                                                              1 (5%)                                
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Polyarteritis                                                 1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (1)          (20)         (10)         (20)                                   
      Degeneration, Cystic                                                                    1 (5%)                                
      Fibrous Osteodystrophy                                        1 (5%)                                                          
   Skeletal Muscle                                                 (1)                                                              
      Polyarteritis                                                 1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (19)         (10)         (18)                                   
      Hydrocephalus                                                 1 (5%)                                                          
      Polyarteritis                                                 1 (5%)                                                          
      Hypothalamus, Compression                                                               1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (20)         (10)         (20)                                   
      Congestion                                       1 (5%)                                                                       
      Polyarteritis                                                 1 (5%)                                                          
      Alveolar Epithelium, Hyperplasia                                                        1 (5%)                                
      Alveolus, Congestion                                                                    1 (5%)                                
      Alveolus, Edema                                               1 (5%)                    1 (5%)                                
      Alveolus, Hemorrhage                                                                    1 (5%)                                
      Alveolus, Inflammation, Chronic                                                         1 (5%)                                
      Bronchiole, Inflammation, Suppurative                                                   1 (5%)                                
   Nose                                               (1)          (20)         (10)         (18)                                   
      Inflammation, Suppurative                                                  2 (20%)                                            
      Lumen, Fungus                                                                           1 (6%)                                
      Lumen, Inflammation, Suppurative                              1 (5%)                    1 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Inflammation, Suppurative                                                       2 (11%)                               
      Mucosa, Metaplasia, Squamous                                                            1 (6%)                                
      Nasolacrimal Duct, Inflammation, Chronic         1 (100%)                                                                     
      Submucosa, Congestion                            1 (100%)                                                                     
   Trachea                                            (1)          (20)         (10)         (20)                                   
      Inflammation, Suppurative                                     1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Lens, Cataract                                                1 (100%)                                                        
      Retina, Degeneration                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (10)         (20)                                   
      Nephropathy                                     18 (90%)     19 (95%)     10 (100%)    20 (100%)                              
      Polyarteritis                                                 1 (5%)                                                          
      Cortex, Cyst                                                                            3 (15%)                               
      Renal Tubule, Hyperplasia                                     1 (5%)                    2 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------