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TDMS Study 05091-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          DIHYDROCOUMARIN


NTP Experiment-Test: 05091-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 08:09:01




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10            9                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       2            4                         2                                     
    Moribund                                          13           17           20           19                                     
    Dead                                               4            8            4            5                                     
    Dosing Accident                                                 1                                                               
    Accident                                                                                  2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           21           26           23                                     
  Animals Examined Microscopically                    60           58           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (51)         (50)         (59)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
   Intestine Large, Cecum                             (56)         (43)         (47)         (57)                                   
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (58)         (45)         (47)         (57)                                   
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (60)         (52)         (52)         (59)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Basophilic Focus                                 3 (5%)       4 (8%)                                                          
      Clear Cell Focus                                 3 (5%)       1 (2%)       6 (12%)      8 (14%)                               
      Congestion                                                                 1 (2%)       1 (2%)                                
      Developmental Malformation                       8 (13%)      6 (12%)      6 (12%)      4 (7%)                                
      Eosinophilic Focus                                            1 (2%)                    1 (2%)                                
      Fatty Change                                     3 (5%)       7 (13%)      6 (12%)      1 (2%)                                
      Inflammation, Chronic                           23 (38%)     18 (35%)     20 (38%)     10 (17%)                               
      Mixed Cell Focus                                                           1 (2%)       1 (2%)                                
      Necrosis, Coagulative                                         7 (13%)      4 (8%)       2 (3%)                                
      Bile Duct, Hyperplasia                           6 (10%)      5 (10%)      5 (10%)      7 (12%)                               
      Central Vein, Dilatation                         1 (2%)                                                                       
      Centrilobular, Necrosis, Coagulative                          2 (4%)                    2 (3%)                                
      Hepatocyte, Cytoplasmic Alteration                                                      1 (2%)                                
      Hepatocyte, Hyperplasia                          1 (2%)       1 (2%)       2 (4%)       2 (3%)                                
      Periductular, Fibrosis                           1 (2%)       4 (8%)       1 (2%)       2 (3%)                                
      Periductular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                             2 (4%)                                             
      Periductular, Inflammation, Chronic              4 (7%)                                 3 (5%)                                
      Periductular, Inflammation, Suppurative                                                 1 (2%)                                
      Sinusoid, Dilatation                             1 (2%)                                                                       
   Mesentery                                          (7)          (5)          (4)          (6)                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Inflammation, Chronic                       1 (14%)      2 (40%)                                                         
      Fat, Inflammation, Chronic Active                                                       1 (17%)                               
      Fat, Necrosis, Coagulative                       6 (86%)      2 (40%)      3 (75%)      3 (50%)                               
      Fat, Necrosis, Liquifactive                                                             1 (17%)                               
   Pancreas                                           (58)         (46)         (49)         (58)                                   
      Atrophy                                          2 (3%)       7 (15%)      5 (10%)      5 (9%)                                
      Ectopic Tissue                                                1 (2%)       1 (2%)                                             
      Hemorrhage, Chronic                                           1 (2%)                                                          
      Hyperplasia                                                   2 (4%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic                                         3 (7%)                    1 (2%)                                
      Necrosis, Coagulative                                         1 (2%)                                                          
      Interstitium, Fibrosis                                                                  2 (3%)                                
   Salivary Glands                                    (60)         (51)         (50)         (59)                                   
      Periductular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   1 (2%)                                                                       
      Submandibular Gland, Inflammation, Chronic       1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (49)         (50)         (58)                                   
      Fibrosis                                                                                1 (2%)                                
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Squamous                            1 (2%)                    1 (2%)       2 (3%)                                
      Inflammation, Chronic                            1 (2%)                                 2 (3%)                                
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Mineralization                                   2 (3%)                                 3 (5%)                                
      Ulcer                                            3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (60)         (48)         (48)         (57)                                   
      Erosion                                                                    1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Ulcer                                            1 (2%)       1 (2%)                    3 (5%)                                
      Mucosa, Dilatation                                                         1 (2%)                                             
   Tongue                                                          (2)          (1)                                                 
      Hyperkeratosis                                                1 (50%)                                                         
      Hyperplasia, Squamous                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (51)         (51)         (59)                                   
      Cardiomyopathy                                  13 (22%)     16 (31%)     18 (35%)     10 (17%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
      Atrioventricular Valve, Fibrosis                                           1 (2%)                                             
      Atrium, Thrombosis                                                         1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (51)         (49)         (59)                                   
      Angiectasis                                                                1 (2%)                                             
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion                                                                              1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Necrosis, Coagulative                                         1 (2%)                                                          
      Vacuolization Cytoplasmic                                     4 (8%)                    1 (2%)                                
   Adrenal Gland, Medulla                             (60)         (51)         (49)         (59)                                   
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                      9 (15%)     10 (20%)      8 (16%)      8 (14%)                               
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (46)         (50)         (58)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                                                          
   Parathyroid Gland                                  (51)         (44)         (46)         (53)                                   
      Hyperplasia                                                                             2 (4%)                                
   Pituitary Gland                                    (59)         (49)         (52)         (59)                                   
      Congestion                                                                              1 (2%)                                
      Pars Distalis, Cyst                              4 (7%)       6 (12%)      3 (6%)       8 (14%)                               
      Pars Distalis, Cyst Multilocular                 6 (10%)      4 (8%)       2 (4%)                                             
      Pars Distalis, Cytoplasmic Alteration                         1 (2%)                                                          
      Pars Distalis, Hemorrhage                                     1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia                       1 (2%)                                 1 (2%)                                
      Pars Distalis, Pigmentation, Hemosiderin                                   1 (2%)                                             
      Pars Intermedia, Hemorrhage                                                1 (2%)                                             
      Pars Nervosa, Cyst                               1 (2%)                                                                       
   Thyroid Gland                                      (59)         (48)         (50)         (59)                                   
      C-Cell, Hyperplasia                              6 (10%)      4 (8%)       7 (14%)      2 (3%)                                
      Follicle, Cyst                                   2 (3%)                    1 (2%)       1 (2%)                                
      Follicle, Dilatation                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (50)         (50)         (59)                                   
      Hyperplasia                                      2 (4%)       3 (6%)       2 (4%)                                             
      Inflammation, Suppurative                        3 (5%)       4 (8%)       5 (10%)      4 (7%)                                
      Duct, Dilatation                                 3 (5%)       2 (4%)       2 (4%)       2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Duct, Inflammation, Suppurative                                            1 (2%)                                             
   Ovary                                              (60)         (51)         (50)         (59)                                   
      Follicle, Cyst                                   4 (7%)       4 (8%)       3 (6%)       4 (7%)                                
   Uterus                                             (60)         (54)         (55)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hydrometra                                       5 (8%)       6 (11%)      6 (11%)      8 (13%)                               
      Hyperplasia, Cystic                                           2 (4%)       6 (11%)      3 (5%)                                
      Cervix, Inflammation, Suppurative                                          1 (2%)       1 (2%)                                
   Vagina                                                          (5)                       (3)                                    
      Hyperkeratosis                                                1 (20%)                                                         
      Hyperplasia, Squamous                                         1 (20%)                                                         
      Inflammation, Suppurative                                     2 (40%)                   3 (100%)                              
      Metaplasia, Squamous                                          1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (50)         (59)                                   
      Hyperplasia, Neutrophil                                       1 (2%)                                                          
      Myelofibrosis                                                                           1 (2%)                                
   Lymph Node                                         (60)         (51)         (52)         (59)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inguinal, Hyperplasia, Plasma Cell                            1 (2%)                                                          
      Lumbar, Hyperplasia, Histiocytic                                                        1 (2%)                                
      Lumbar, Pigmentation, Hemosiderin                                          1 (2%)                                             
      Mediastinal, Congestion                                                                 1 (2%)                                
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
      Mediastinal, Hyperplasia, Histiocytic                                                   1 (2%)                                
      Mediastinal, Hyperplasia, Macrophage                                       1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                                                   1 (2%)                                
      Mediastinal, Necrosis, Coagulative                            1 (2%)                                                          
      Prefemoral, Hyperplasia, Lymphoid                1 (2%)                    1 (2%)                                             
   Lymph Node, Mandibular                             (58)         (51)         (49)         (58)                                   
      Hyperplasia, Lymphoid                            2 (3%)       2 (4%)                    3 (5%)                                
      Hyperplasia, Plasma Cell                                      1 (2%)                    2 (3%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (60)         (50)         (50)         (59)                                   
      Congestion                                                                 1 (2%)                                             
   Spleen                                             (60)         (49)         (49)         (58)                                   
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                    3 (6%)       4 (7%)                                
      Depletion Lymphoid                               1 (2%)                                                                       
      Developmental Malformation                                                              1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Hyperplasia, Lymphoid                                         2 (4%)       1 (2%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Reticulum Cell                                   1 (2%)                    1 (2%)                                
      Necrosis, Coagulative                                         1 (2%)                                                          
      Necrosis, Liquifactive                           1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                               2 (3%)                                
      Capsule, Hemorrhage                                           1 (2%)                                                          
   Thymus                                             (53)         (47)         (50)         (58)                                   
      Epithelial Cell, Cyst                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (50)         (49)         (59)                                   
      Galactocele                                      3 (5%)       2 (4%)       3 (6%)                                             
      Lactation                                        1 (2%)       1 (2%)       1 (2%)                                             
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Skin                                               (60)         (51)         (50)         (59)                                   
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
          Inclusion                                                                           1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
      Tail, Hyperkeratosis                                                                    1 (2%)                                
      Tail, Inflammation, Suppurative                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (48)         (58)                                   
      Hemorrhage                                       1 (2%)       2 (4%)                    1 (2%)                                
      Hydrocephalus                                    1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Necrosis, Liquifactive                                        1 (2%)                                                          
      Cerebellum, Gliosis                                                                     1 (2%)                                
      Hypothalamus, Compression                        1 (2%)                    3 (6%)                                             
      Meninges, Inflammation, Chronic                  1 (2%)                                                                       
      Thalamus, Compression                            2 (3%)       2 (4%)       2 (4%)       1 (2%)                                
      Thalamus, Necrosis, Coagulative                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (50)         (59)                                   
      Congestion                                                    2 (4%)                    1 (2%)                                
      Edema                                                         2 (4%)                    2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 3 (5%)       4 (8%)       3 (6%)       1 (2%)                                
      Alveolus, Edema                                  1 (2%)                                                                       
      Alveolus, Foreign Body                                                                  2 (3%)                                
      Alveolus, Hemorrhage                             1 (2%)                                                                       
      Alveolus, Inflammation, Chronic                 10 (17%)      1 (2%)       1 (2%)       1 (2%)                                
      Alveolus, Inflammation, Suppurative                           1 (2%)                                                          
   Nose                                               (60)         (51)         (50)         (59)                                   
      Congestion                                                                              1 (2%)                                
      Lumen, Fungus                                    2 (3%)                    2 (4%)                                             
      Lumen, Inflammation, Chronic                     1 (2%)                                                                       
      Lumen, Inflammation, Suppurative                 3 (5%)       2 (4%)       1 (2%)       5 (8%)                                
      Mucosa, Inflammation, Chronic Active             1 (2%)                                                                       
      Mucosa, Inflammation, Suppurative                1 (2%)                    1 (2%)       2 (3%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (3)          (2)                                    
      Iris, Synechia                                                             1 (33%)                                            
      Lens, Cataract                                   1 (100%)                  1 (33%)      1 (50%)                               
      Posterior Chamber, Hemorrhage                                              1 (33%)                                            
      Retina, Atrophy                                  1 (100%)                                                                     
      Retina, Dysplasia                                                          1 (33%)                                            
   Lacrimal Gland                                                  (1)                                                              
      Pigmentation, Porphyrin                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (50)         (58)                                   
      Hydronephrosis                                                2 (4%)                                                          
      Nephropathy                                     22 (37%)     21 (42%)     38 (76%)     32 (55%)                               
      Collecting Tubule, Mineralization                1 (2%)                                                                       
      Cortex, Cyst                                     1 (2%)                    1 (2%)                                             
      Cortex, Necrosis, Coagulative                    1 (2%)                                                                       
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                   2 (3%)                                                                       
      Pelvis, Inflammation, Chronic                                 1 (2%)       1 (2%)       1 (2%)                                
      Pelvis, Mineralization                                        1 (2%)                                                          
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
   Urinary Bladder                                    (58)         (50)         (48)         (58)                                   
      Developmental Malformation                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           20           10           60           60           60           
  Scheduled Sacrifice                                  9           19           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund                                          12                                     23           26           17           
    Gavage Death                                       1            1                         1            1            2           
    Dead                                               9                                     13           15           29           
    Dosing Accident                                    1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                27                                     12            8            2           
    Moribund                                                                                  1                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    60           20           10           60           60           60           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (54)                      (10)         (44)         (44)         (42)         
      Circumanal Gland, Hyperplasia, Glandular                                                1 (2%)                                
   Intestine Large, Cecum                             (50)                      (10)         (42)         (41)         (34)         
      Inflammation, Suppurative                                                                                         1 (3%)      
      Submucosa, Edema                                                                                                  1 (3%)      
      Submucosa, Inflammation, Suppurative                                                                 1 (2%)                   
   Intestine Small, Jejunum                           (50)                      (10)         (42)         (43)         (40)         
      Hemorrhage                                                                                           1 (2%)                   
   Liver                                              (58)         (20)         (10)         (49)         (53)         (60)         
      Angiectasis                                                                             3 (6%)       1 (2%)                   
      Basophilic Focus                                 2 (3%)                                 1 (2%)                                
      Clear Cell Focus                                 3 (5%)                    1 (10%)                   1 (2%)       4 (7%)      
      Congestion                                       1 (2%)                                                                       
      Cytologic Alterations                            1 (2%)                                                                       
      Developmental Malformation                       6 (10%)                                5 (10%)      2 (4%)       5 (8%)      
      Fatty Change                                     9 (16%)     10 (50%)      1 (10%)      7 (14%)                               
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Inflammation, Chronic                            6 (10%)                   1 (10%)                                1 (2%)      
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Necrotizing                                                                            1 (2%)                   
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)                                
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Coagulative                                         1 (5%)                    4 (8%)       1 (2%)       4 (7%)      
      Regeneration                                                                                                      1 (2%)      
      Artery, Dilatation                                                                                                1 (2%)      
      Bile Duct, Cyst                                                                                                   1 (2%)      
      Bile Duct, Hyperplasia                          29 (50%)      2 (10%)      4 (40%)     17 (35%)     13 (25%)     10 (17%)     
      Centrilobular, Inflammation, Necrotizing                                                                          1 (2%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis, Coagulative             2 (3%)                                 1 (2%)       8 (15%)      5 (8%)      
      Hepatocyte, Hyperplasia                                                                 1 (2%)       3 (6%)       1 (2%)      
      Periductular, Fibrosis                           7 (12%)                                6 (12%)      9 (17%)      4 (7%)      
      Periductular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                                          1 (2%)                                
      Periductular, Inflammation, Chronic              4 (7%)                    1 (10%)      1 (2%)                    1 (2%)      
      Periportal, Necrosis, Coagulative                1 (2%)                                                                       
      Periportal, Pigmentation, Hemosiderin            1 (2%)                                                                       
      Portal, Pigmentation, Hemosiderin                1 (2%)                                                                       
   Mesentery                                          (19)         (1)          (1)          (16)         (11)         (7)          
      Granuloma                                                     1 (100%)                                                        
      Fat, Inflammation, Chronic                       1 (5%)                    1 (100%)     1 (6%)       1 (9%)                   
      Fat, Inflammation, Chronic Active                                                                    2 (18%)                  
      Fat, Inflammation, Granulomatous                 1 (5%)                                                                       
      Fat, Inflammation, Suppurative                   1 (5%)                                                                       
      Fat, Inflammation, Fibrinopurulent                                                      3 (19%)                               
      Fat, Necrosis, Coagulative                      13 (68%)                               11 (69%)      6 (55%)      6 (86%)     
   Pancreas                                           (58)         (20)         (10)         (47)         (48)         (48)         
      Atrophy                                          9 (16%)      2 (10%)                   4 (9%)       1 (2%)       1 (2%)      
      Ectopic Tissue                                                                          1 (2%)                                
      Fibrosis                                                                   2 (20%)                                            
      Hemorrhage                                                                                           1 (2%)                   
      Hyperplasia                                                                             5 (11%)      4 (8%)       4 (8%)      
      Inflammation, Chronic                            1 (2%)                                              1 (2%)       1 (2%)      
      Inflammation, Necrotizing                                                               1 (2%)                                
      Inflammation, Suppurative                                                                                         1 (2%)      
      Necrosis, Liquifactive                                                                                            1 (2%)      
      Polyarteritis                                                                                        1 (2%)                   
      Acinar Cell, Hyperplasia                         1 (2%)                                                                       
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                                                                                    1 (2%)      
   Stomach, Forestomach                               (56)         (20)         (10)         (48)         (50)         (56)         
      Cyst Epithelial Inclusion                        1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                                           1 (2%)                   
      Hyperkeratosis                                                                                       1 (2%)       1 (2%)      
      Hyperplasia, Squamous                            3 (5%)                                11 (23%)     14 (28%)     11 (20%)     
      Inflammation, Chronic                            3 (5%)                                 8 (17%)     15 (30%)      8 (14%)     
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            4 (7%)                                14 (29%)     20 (40%)     16 (29%)     
   Stomach, Glandular                                 (55)         (20)         (10)         (47)         (50)         (53)         
      Erosion                                          1 (2%)                                 3 (6%)       4 (8%)       4 (8%)      
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 2 (4%)       1 (2%)       1 (2%)      
      Mineralization                                                                          1 (2%)                                
      Ulcer                                                                                   1 (2%)       1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (20)         (10)         (50)         (50)         (60)         
      Cardiomyopathy                                  45 (76%)     17 (85%)      6 (60%)     33 (66%)     34 (68%)     40 (67%)     
      Necrosis, Zenkers                                                                                    1 (2%)                   
      Atrioventricular Valve, Fibrosis                                                                                  1 (2%)      
      Atrioventricular Valve, Thrombosis                                                                   1 (2%)                   
      Atrium, Inflammation, Suppurative                                                                                 1 (2%)      
      Atrium, Thrombosis                                                                      1 (2%)       2 (4%)       2 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (20)         (9)          (49)         (49)         (60)         
      Basophilic Focus                                 1 (2%)                                                                       
      Cytoplasmic Alteration                                                                  1 (2%)                    1 (2%)      
      Hemorrhage                                                                              1 (2%)                                
      Vacuolization Cytoplasmic                                                               6 (12%)      2 (4%)                   
   Adrenal Gland, Medulla                             (59)         (20)         (9)          (49)         (49)         (60)         
      Cyst                                             1 (2%)                                 1 (2%)                                
      Hyperplasia                                      3 (5%)                                 2 (4%)       5 (10%)      2 (3%)      
      Inflammation, Suppurative                                                                                         1 (2%)      
      Necrosis, Coagulative                            1 (2%)                                                                       
      Necrosis, Liquifactive                                                                  1 (2%)                                
   Parathyroid Gland                                  (56)         (16)         (10)         (41)         (48)         (51)         
      Hyperplasia                                                                            15 (37%)     26 (54%)     19 (37%)     
   Pituitary Gland                                    (58)         (20)         (9)          (48)         (48)         (56)         
      Inflammation, Suppurative                                                               1 (2%)                                
      Pars Distalis, Cyst                              2 (3%)                                 4 (8%)       7 (15%)      1 (2%)      
      Pars Distalis, Cyst Multilocular                 1 (2%)                                 1 (2%)       1 (2%)       1 (2%)      
      Pars Distalis, Hemorrhage, Acute                                                                     1 (2%)                   
      Pars Distalis, Hemorrhage, Chronic                                                      1 (2%)                                
      Pars Distalis, Hyperplasia                       2 (3%)                                                                       
      Pars Distalis, Hypertrophy                                                 2 (22%)                                            
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (59)         (20)         (10)         (48)         (49)         (50)         
      C-Cell, Hyperplasia                              2 (3%)                                 4 (8%)       3 (6%)       3 (6%)      
      Follicle, Cyst                                                                                                    2 (4%)      
      Follicle, Hyperplasia                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)          (1)          (1)          
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)                                                                           
      Inflammation, Suppurative                        1 (50%)                                                                      
      Lumen, Dilatation                                1 (50%)                                                                      
   Epididymis                                         (58)         (20)         (10)         (50)         (48)         (57)         
      Polyarteritis                                                                           1 (2%)                                
   Preputial Gland                                    (56)         (2)          (10)         (49)         (48)         (59)         
      Hyperplasia                                      3 (5%)                                 2 (4%)       6 (13%)      2 (3%)      
      Inflammation, Chronic                            1 (2%)                                 1 (2%)       1 (2%)       2 (3%)      
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                        4 (7%)                                 9 (18%)      7 (15%)      7 (12%)     
      Duct, Dilatation                                 1 (2%)                                 2 (4%)       2 (4%)       2 (3%)      
      Duct, Inflammation, Suppurative                                                         1 (2%)       1 (2%)       2 (3%)      
   Prostate                                           (54)         (20)         (10)         (48)         (46)         (59)         
      Hyperplasia                                      1 (2%)                                              1 (2%)                   
      Inflammation, Suppurative                        9 (17%)      1 (5%)                    8 (17%)     12 (26%)      5 (8%)      
      Interstitium, Hemorrhage, Acute                                                                                   1 (2%)      
   Seminal Vesicle                                    (58)         (20)         (10)         (49)         (46)         (59)         
      Inflammation, Suppurative                        3 (5%)                                                           1 (2%)      
      Lumen, Dilatation                                1 (2%)                                                                       
   Testes                                             (58)         (20)         (10)         (52)         (51)         (56)         
      Atrophy                                          4 (7%)                                 3 (6%)       4 (8%)       3 (5%)      
      Degeneration                                                  1 (5%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Polyarteritis                                                                           1 (2%)                                
      Interstitial Cell, Hyperplasia                   3 (5%)      11 (55%)      2 (20%)      1 (2%)       2 (4%)       4 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (56)         (1)          (10)         (49)         (50)         (56)         
      Hypercellularity                                                                        1 (2%)                                
      Hyperplasia, Neutrophil                                                                              1 (2%)                   
      Myelofibrosis                                                                                        1 (2%)                   
   Lymph Node                                         (60)         (20)         (10)         (49)         (50)         (58)         
      Lumbar, Congestion                                                                                   1 (2%)                   
      Mediastinal, Congestion                                                                              1 (2%)       2 (3%)      
      Mediastinal, Inflammation, Suppurative                                                               1 (2%)                   
      Mediastinal, Pigmentation, Hemosiderin                                                               1 (2%)                   
      Pancreatic, Hyperplasia, Plasma Cell                                                                 1 (2%)                   
      Renal, Hyperplasia, Plasma Cell                                                         1 (2%)                                
   Lymph Node, Mandibular                             (59)         (20)         (10)         (48)         (44)         (52)         
      Congestion                                                                                                        1 (2%)      
      Hyperplasia, Lymphoid                            2 (3%)                                 4 (8%)                    2 (4%)      
      Hyperplasia, Plasma Cell                         2 (3%)                                 2 (4%)       2 (5%)       1 (2%)      
      Inflammation, Suppurative                                                                            1 (2%)                   
   Lymph Node, Mesenteric                             (59)         (1)          (10)         (49)         (50)         (57)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                                                           1 (2%)                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                                                                   2 (4%)                                
      Inflammation, Suppurative                                                                            1 (2%)                   
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spleen                                             (58)         (20)         (10)         (48)         (45)         (55)         
      Atrophy                                          2 (3%)                                                                       
      Congestion                                       4 (7%)                                 3 (6%)       2 (4%)                   
      Congestion, Diffuse                                                                                  1 (2%)                   
      Developmental Malformation                       1 (2%)                                 2 (4%)       1 (2%)                   
      Fibrosis                                                                                1 (2%)                    1 (2%)      
      Hyperplasia, Lymphoid                            1 (2%)                                 3 (6%)       1 (2%)                   
      Hyperplasia, Macrophage                                                                              2 (4%)                   
      Infiltration Cellular, Mononuclear Cell                                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)       1 (2%)                   
      Necrosis, Liquifactive                                                                                            2 (4%)      
      Pigmentation, Hemosiderin                                                               1 (2%)                    1 (2%)      
      Perivascular, Fibrosis                                                                  1 (2%)                                
      Subcapsular, Hemorrhage                                                                                           1 (2%)      
   Thymus                                             (55)         (1)          (10)         (47)         (47)         (55)         
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                                                              1 (2%)                    1 (2%)      
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
      Inflammation, Suppurative                                                                            1 (2%)                   
      Capsule, Inflammation, Suppurative                                                                                1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (1)          (8)          (46)         (47)         (53)         
      Galactocele                                                                             2 (4%)       1 (2%)                   
   Skin                                               (60)         (1)          (10)         (50)         (48)         (59)         
      Alopecia                                                                                1 (2%)       2 (4%)       1 (2%)      
      Cyst Epithelial Inclusion                        1 (2%)                                              1 (2%)       1 (2%)      
      Hyperkeratosis                                                                                       1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                                           1 (2%)      
      Inflammation, Suppurative                                                                            1 (2%)                   
      Ulcer                                            1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Developmental                                                                                            
          Malformation                                                                                     1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (1)          (10)         (50)         (50)         (60)         
      Degeneration                                     1 (2%)                                                                       
   Skeletal Muscle                                                                           (1)                                    
      Metaplasia, Osseous                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)         (20)         (10)         (49)         (46)         (57)         
      Hemorrhage                                                                              1 (2%)                                
      Hypothalamus, Hemorrhage, Acute                                                                      1 (2%)                   
      Meninges, Congestion                                                                    1 (2%)                                
      Thalamus, Compression                            2 (4%)                                                                       
      Thalamus, Necrosis                                                                                                1 (2%)      
   Peripheral Nerve                                   (2)                                    (1)          (7)          (3)          
      Degeneration, Secondary Wallerian                1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (20)         (10)         (50)         (50)         (60)         
      Congestion                                                    1 (5%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (7%)       1 (5%)       1 (10%)      3 (6%)       3 (6%)       3 (5%)      
      Alveolus, Congestion                                                                                              1 (2%)      
      Alveolus, Edema                                  1 (2%)                                 2 (4%)                    1 (2%)      
      Alveolus, Foreign Body                                                                                            1 (2%)      
      Alveolus, Hemorrhage                                                                    2 (4%)       2 (4%)       1 (2%)      
      Alveolus, Inflammation, Chronic                  2 (3%)                                                                       
      Alveolus, Inflammation, Suppurative              2 (3%)                    1 (10%)      2 (4%)                    2 (3%)      
      Bronchiole, Inflammation, Suppurative            1 (2%)                                                           1 (2%)      
   Nose                                               (59)         (1)          (10)         (50)         (48)         (59)         
      Autolysis                                                                                            1 (2%)                   
      Fungus                                           1 (2%)                                              2 (4%)       1 (2%)      
      Inflammation, Chronic                                                      3 (30%)                   1 (2%)                   
      Metaplasia, Squamous                             1 (2%)                                                                       
      Lumen, Foreign Body                              1 (2%)                                                           2 (3%)      
      Lumen, Fungus                                    3 (5%)                    3 (30%)      5 (10%)      6 (13%)      4 (7%)      
      Lumen, Inflammation, Suppurative                 8 (14%)                                8 (16%)      9 (19%)      8 (14%)     
      Mucosa, Inflammation, Suppurative                1 (2%)                                 2 (4%)       2 (4%)       1 (2%)      
      Mucosa, Septum, Inflammation, Chronic            1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative                                                         2 (4%)       1 (2%)      
   Trachea                                            (60)         (1)          (10)         (50)         (50)         (58)         
      Inflammation, Suppurative                                                               2 (4%)       1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)          (1)          (2)          
      Acanthosis                                                                                           1 (100%)                 
      Pinna, Perforation                                                                      1 (100%)                              
   Eye                                                (1)          (1)                       (2)                       (1)          
      Anterior Chamber, Hemorrhage, Chronic            1 (100%)                                                                     
      Bilateral, Lens, Cataract                                                               1 (50%)                               
      Lens, Cataract                                                                          1 (50%)                   1 (100%)    
      Retina, Degeneration                                                                    1 (50%)                   1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (20)         (10)         (58)         (57)         (60)         
      Congestion                                                    1 (5%)                                                          
      Fibrosis                                                                                                          1 (2%)      
      Inflammation, Suppurative                                                                                         1 (2%)      
      Nephropathy                                     59 (100%)    19 (95%)     10 (100%)    57 (98%)     57 (100%)    57 (95%)     
      Cortex, Cyst                                     3 (5%)                                                           1 (2%)      
      Cortex, Infarct                                                                                      1 (2%)       1 (2%)      
      Pelvis, Inflammation, Chronic                                                                                     1 (2%)      
      Pelvis, Inflammation, Suppurative                2 (3%)                                                           1 (2%)      
      Renal Tubule, Hyperplasia                                                               3 (5%)                    3 (5%)      
      Renal Tubule, Hyperplasia, Cystic                1 (2%)                                              2 (4%)       1 (2%)      
      Renal Tubule, Hyperplasia, Oncocytic             1 (2%)                                              1 (2%)                   
   Ureter                                             (1)                                                                           
      Mucosa, Inflammation, Suppurative                1 (100%)                                                                     
   Urinary Bladder                                    (58)         (20)         (10)         (48)         (44)         (48)         
      Mucosa, Inflammation, Suppurative                1 (2%)                                 1 (2%)                                
      Serosa, Inflammation, Suppurative                                                       1 (2%)                                
      Submucosa, Infiltration Cellular, Lymphocyte                                                         1 (2%)                   
      Submucosa, Inflammation, Suppurative             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          20           20           10           20                                     
  Scheduled Sacrifice                                 19                        10                                                  
  Early Deaths                                                                                                                      
    Gavage Death                                       1                                                                            
    Moribund                                                        6                        10                                     
    Dead                                                            5                         8                                     
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Dead                                                            1                                                               
    Terminal Sacrifice                                              7                         2                                     
  Animals Examined Microscopically                    20           20           10           20                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (1)          (13)         (10)         (17)                                   
      Polyarteritis                                                 1 (8%)                                                          
   Intestine Large, Rectum                            (1)          (16)         (10)         (18)                                   
      Polyarteritis                                                 1 (6%)                                                          
   Intestine Small, Jejunum                           (1)          (14)         (9)          (19)                                   
      Diverticulum                                                                            1 (5%)                                
   Liver                                              (20)         (19)         (10)         (19)                                   
      Angiectasis                                                                             1 (5%)                                
      Congestion                                       1 (5%)                                                                       
      Developmental Malformation                       1 (5%)                                 1 (5%)                                
      Ectasia                                                                                 1 (5%)                                
      Fatty Change                                                  2 (11%)                   1 (5%)                                
      Inflammation, Suppurative                                     2 (11%)                   1 (5%)                                
      Necrosis, Coagulative                                         2 (11%)                                                         
      Bile Duct, Hyperplasia                           6 (30%)      2 (11%)      1 (10%)      1 (5%)                                
      Hepatocyte, Hyperplasia                                       1 (5%)                                                          
      Kupffer Cell, Hyperplasia                        1 (5%)                                                                       
   Mesentery                                                       (3)          (1)                                                 
      Polyarteritis                                                 1 (33%)                                                         
      Fat, Necrosis, Chronic                                                     1 (100%)                                           
      Fat, Necrosis, Coagulative                                    3 (100%)                                                        
   Pancreas                                           (20)         (19)         (10)         (20)                                   
      Atrophy                                                                                 1 (5%)                                
      Fibrosis                                                                   1 (10%)                                            
      Hyperplasia                                                                             3 (15%)                               
      Inflammation, Chronic                            1 (5%)                                                                       
      Polyarteritis                                                 1 (5%)                                                          
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                                             1 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (20)         (19)         (10)         (20)                                   
      Hyperplasia, Squamous                            1 (5%)       2 (11%)                   1 (5%)                                
      Inflammation, Chronic                                         2 (11%)                   4 (20%)                               
      Ulcer                                                         2 (11%)                   4 (20%)                               
   Stomach, Glandular                                 (20)         (18)         (10)         (20)                                   
      Erosion                                                                    1 (10%)      1 (5%)                                
      Mineralization                                                1 (6%)                    5 (25%)                               
      Polyarteritis                                                 1 (6%)                                                          
      Ulcer                                                                                   1 (5%)                                
   Tongue                                                          (1)                                                              
      Parenchyma, Edema                                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (3)                       (4)                                    
      Aorta, Mineralization                                         1 (33%)                   2 (50%)                               
      Pulmonary Artery, Mineralization                                                        1 (25%)                               
   Heart                                              (20)         (20)         (10)         (20)                                   
      Cardiomyopathy                                  13 (65%)      8 (40%)      8 (80%)      9 (45%)                               
      Necrosis, Zenkers                                             1 (5%)                    1 (5%)                                
      Polyarteritis                                                 1 (5%)                                                          
      Artery, Mineralization                                                                  1 (5%)                                
      Atrioventricular Valve, Fibrosis                              1 (5%)                                                          
      Atrium, Thrombosis                                            1 (5%)                                                          
      Valve, Fibrosis                                               1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (20)         (10)         (20)                                   
      Clear Cell Focus                                              1 (5%)                                                          
      Cytoplasmic Alteration                                        1 (5%)                                                          
      Vacuolization Cytoplasmic                                     1 (5%)                    1 (5%)                                
   Adrenal Gland, Medulla                             (19)         (20)         (10)         (20)                                   
      Hyperplasia                                                   1 (5%)                    1 (5%)                                
      Infiltration Cellular, Lymphocyte                                          1 (10%)                                            
      Necrosis, Liquifactive                                                                  1 (5%)                                
   Parathyroid Gland                                  (20)         (18)         (10)         (18)                                   
      Hyperplasia                                                   6 (33%)                   9 (50%)                               
   Pituitary Gland                                    (20)         (18)         (10)         (18)                                   
      Pars Distalis, Congestion                                                  1 (10%)                                            
      Pars Distalis, Cyst                                                        2 (20%)      1 (6%)                                
      Pars Distalis, Hemorrhage, Acute                                                        1 (6%)                                
   Thyroid Gland                                      (20)         (18)         (10)         (18)                                   
      Polyarteritis                                                 1 (6%)                                                          
      C-Cell, Hyperplasia                                           1 (6%)                    1 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Cyst                                                1 (6%)                    1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (1)          (20)         (10)         (20)                                   
      Abscess                                                       1 (5%)       1 (10%)                                            
      Hyperplasia                                                                             2 (10%)                               
      Inflammation, Chronic                                                      2 (20%)                                            
      Inflammation, Suppurative                                     1 (5%)                    3 (15%)                               
      Polyarteritis                                                 1 (5%)                                                          
      Duct, Dilatation                                              1 (5%)                                                          
      Duct, Inflammation, Chronic                                                             1 (5%)                                
      Duct, Inflammation, Suppurative                                                         1 (5%)                                
   Prostate                                           (20)         (20)         (10)         (20)                                   
      Inflammation, Chronic Active                     4 (20%)                                                                      
      Inflammation, Suppurative                                     3 (15%)                   3 (15%)                               
   Testes                                             (20)         (20)         (10)         (20)                                   
      Atrophy                                                                                 1 (5%)                                
      Interstitial Cell, Hyperplasia                   9 (45%)      1 (5%)       3 (30%)      1 (5%)                                
      Seminiferous Tubule, Degeneration                3 (15%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (20)         (20)         (10)         (20)                                   
      Hyperplasia, Plasma Cell                                      1 (5%)                                                          
      Mediastinal, Hemorrhage, Acute                                                          1 (5%)                                
      Mediastinal, Polyarteritis                                    1 (5%)                                                          
      Renal, Congestion                                                                       1 (5%)                                
      Renal, Hyperplasia, Macrophage                                1 (5%)                                                          
      Renal, Pigmentation, Hemosiderin                              1 (5%)                                                          
   Lymph Node, Mandibular                             (20)         (19)         (10)         (18)                                   
      Angiectasis                                                                             1 (6%)                                
   Lymph Node, Mesenteric                             (2)          (18)         (10)         (20)                                   
      Angiectasis                                                                             1 (5%)                                
   Spleen                                             (20)         (19)         (10)         (20)                                   
      Congestion                                                    1 (5%)                                                          
      Fibrosis                                                                                1 (5%)                                
      Hyperplasia, Lymphoid                                         1 (5%)                                                          
      Pigmentation, Hemosiderin                                     1 (5%)                                                          
   Thymus                                             (1)          (18)         (10)         (19)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                                    1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)          (19)         (9)          (15)                                   
      Galactocele                                                                             1 (7%)                                
      Lactation                                                     1 (5%)                                                          
   Skin                                               (2)          (20)         (10)         (20)                                   
      Cyst Epithelial Inclusion                                                               1 (5%)                                
      Hemorrhage                                                                              1 (5%)                                
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Polyarteritis                                                 1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (1)          (20)         (10)         (20)                                   
      Degeneration, Cystic                                                                    1 (5%)                                
      Fibrous Osteodystrophy                                        1 (5%)                                                          
   Skeletal Muscle                                                 (1)                                                              
      Polyarteritis                                                 1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (19)         (10)         (18)                                   
      Hydrocephalus                                                 1 (5%)                                                          
      Polyarteritis                                                 1 (5%)                                                          
      Hypothalamus, Compression                                                               1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (20)         (10)         (20)                                   
      Congestion                                       1 (5%)                                                                       
      Polyarteritis                                                 1 (5%)                                                          
      Alveolar Epithelium, Hyperplasia                                                        1 (5%)                                
      Alveolus, Congestion                                                                    1 (5%)                                
      Alveolus, Edema                                               1 (5%)                    1 (5%)                                
      Alveolus, Hemorrhage                                                                    1 (5%)                                
      Alveolus, Inflammation, Chronic                                                         1 (5%)                                
      Bronchiole, Inflammation, Suppurative                                                   1 (5%)                                
   Nose                                               (1)          (20)         (10)         (18)                                   
      Inflammation, Suppurative                                                  2 (20%)                                            
      Lumen, Fungus                                                                           1 (6%)                                
      Lumen, Inflammation, Suppurative                              1 (5%)                    1 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05091-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Inflammation, Suppurative                                                       2 (11%)                               
      Mucosa, Metaplasia, Squamous                                                            1 (6%)                                
      Nasolacrimal Duct, Inflammation, Chronic         1 (100%)                                                                     
      Submucosa, Congestion                            1 (100%)                                                                     
   Trachea                                            (1)          (20)         (10)         (20)                                   
      Inflammation, Suppurative                                     1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Lens, Cataract                                                1 (100%)                                                        
      Retina, Degeneration                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (10)         (20)                                   
      Nephropathy                                     18 (90%)     19 (95%)     10 (100%)    20 (100%)                              
      Polyarteritis                                                 1 (5%)                                                          
      Cortex, Cyst                                                                            3 (15%)                               
      Renal Tubule, Hyperplasia                                     1 (5%)                    2 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
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