TDMS Study 05091-01 Pathology Tables
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
Facility: American Biogenics Corp.
Chemical CAS #: 119-84-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|
| 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + M + M + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|
| 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Polyp | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X |
Thoracic, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mandibular, Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + + + + + + + + + + M +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|
| 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|
| 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + M + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|
| 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Adenocarcinoma | X X |
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Polyp | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | |
Thoracic, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Fibroadenoma | X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|
| 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6| | |
| 1| 0| 9| 0| 2| 4| 5| 1| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Adenoma | X | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 6 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X | 36 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6| | |
| 1| 0| 9| 0| 2| 4| 5| 1| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + M + | 57 |
Adenocarcinoma | | 2 |
Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Leiomyoma | X | 1 |
Polyp | X X X | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Deep Cervical, Histiocytic Sarcoma | X | 1 |
Mediastinal, Leukemia Mononuclear | X | 2 |
Thoracic, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 4 |
Mandibular, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + M | 53 |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Fibroadenoma | X X X | 15 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6| | |
| 1| 0| 9| 0| 2| 4| 5| 1| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X | 6 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 6 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + M + + + + | 58 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|
DAY ON TEST | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|
| 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + + + + + + + + + + + A + + + + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + A + + + + M|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Adenocarcinoma, Metastatic, Uterus | X |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + A|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|
DAY ON TEST | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|
| 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Adenoma | X X X |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | |
Carcinoma | X X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oviduct | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Leiomyosarcoma | X |
Leukemia Mononuclear | |
Polyp | X X X X |
Cervix, Leiomyoma | |
__________________________________________________________________________|
Vagina | + + |
Leiomyosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|
DAY ON TEST | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|
| 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + M + + + + + A + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + A|
Fibroadenoma | X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + A|
Fibrous Histiocytoma | X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Peripheral Nerve | + + + M + |
__________________________________________________________________________|
Spinal Cord | + I + + + M |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X |
Renal Tubule, Adenocarcinoma | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|
| 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
150MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + A + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + A + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + + + |
Adenocarcinoma, Metastatic, Uterus | |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + A A + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + A A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + M M M + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + A + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|
| 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
150MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + A + + + + + + + + +|
C-Cell, Adenoma | X |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + +|
Adenocarcinoma | |
Adenoma | X |
Carcinoma | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Oviduct | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Leiomyosarcoma | |
Leukemia Mononuclear | X |
Polyp | X X X X X |
Cervix, Leiomyoma | |
__________________________________________________________________________|
Vagina | + + + |
Leiomyosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|
| 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
150MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + |
__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Renal Tubule, Adenocarcinoma | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 46 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 52 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Fat, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 46 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 2 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 51 |
Leukemia Mononuclear | | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 51 |
Adenoma | | 1 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 51 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X | 5 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X | 21 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 48 |
C-Cell, Adenoma | | 4 |
Follicle, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 50 |
Adenocarcinoma | X | 1 |
Adenoma | | 1 |
Carcinoma | | 3 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 51 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 54 |
Adenocarcinoma | | 1 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
Polyp | X X X X | 13 |
Cervix, Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Vagina | | 5 |
Leiomyosarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 51 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 51 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 50 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 49 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Thymus | + M + + + + | 47 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 50 |
Fibroadenoma | X X | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 51 |
Fibrous Histiocytoma | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 9 |
__________________________________________________________________________|____________|
Spinal Cord | | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 52 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 51 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
Renal Tubule, Adenocarcinoma | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|
| 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Pars Distalis, Adenoma | X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|
| 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Polyp | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Bronchial, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Prefemoral, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
Thoracic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|
| 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Fibroma | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Renal Tubule, Adenocarcinoma | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|
| 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
300MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Mesentery | + |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + +|
Adenoma | |
Pars Distalis, Adenoma | X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|
| 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
300MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Polyp | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Prefemoral, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X |
Thoracic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|
| 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
300MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | M + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Fibroma | X |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Renal Tubule, Adenocarcinoma | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 52 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A | 49 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A | 48 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 51 |
Leukemia Mononuclear | X X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 7 |
Pheochromocytoma Benign | | 5 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 52 |
Adenoma | X | 1 |
Pars Distalis, Adenoma | X X X X X | 27 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A | 50 |
C-Cell, Adenoma | | 1 |
Follicle, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 50 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 55 |
Polyp | X X | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 52 |
Bronchial, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 1 |
Prefemoral, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 2 |
Thoracic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + A | 49 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A | 49 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 49 |
Adenocarcinoma | X | 1 |
Fibroadenoma | X X X X X | 22 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Fibroma | | 1 |
Keratoacanthoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + A | 48 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Fibroma | | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A | 50 |
Leukemia Mononuclear | | 4 |
Renal Tubule, Adenocarcinoma | X | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A | 48 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|
| 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | X X X |
Hepatocyte, Adenoma | X |
__________________________________________________________________________|
Mesentery | + |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|
| 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
Follicle, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp | X X X|
Sarcoma Stromal | |
Cervix, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + + |
Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|
| 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrous Histiocytoma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + A + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Astrocytoma Benign | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | |
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|
| 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + M + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X X X |
Hepatocyte, Adenoma | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + A + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M M + + + + + + M + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|
| 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Adenoma | X |
Pars Distalis, Adenoma | X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
C-Cell, Adenoma | X |
Follicle, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oviduct | + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp | X X |
Sarcoma Stromal | X |
Cervix, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +|
Lumbar, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + M|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|
| 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Fibroadenoma | X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + A + + + + +|
Fibroma | X |
Fibrous Histiocytoma | X |
Squamous Cell Papilloma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + + +|
Cerebellum, Astrocytoma Benign | X |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + A + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X |
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | X X | 8 |
Hepatocyte, Adenoma | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 2 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X | 3 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 53 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Adenoma | | 1 |
Pars Distalis, Adenoma | X X | 19 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Adenoma | X | 2 |
Follicle, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Adenoma | | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Oviduct | + | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 1 |
Polyp | X X X | 8 |
Sarcoma Stromal | | 1 |
Cervix, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 3 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Lumbar, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X X X | 11 |
__________________________________________________________________________|____________|
Thymus | I + + + + + + + + + | 58 |
Leukemia Mononuclear | X X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Fibroadenoma | | 6 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Fibroma | X | 2 |
Fibrous Histiocytoma | | 1 |
Squamous Cell Papilloma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Cerebellum, Astrocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | X X | 3 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|
| 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + A + M +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + A +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + A +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + A +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + A +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Adenoma | |
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|
| 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicle, Adenoma | X |
Follicular Cell, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | X X |
Carcinoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | M M + + + + + + + + + + + M M + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + M + + + + M + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|
| 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Benign | X |
Fibroma | X |
Fibrosarcoma | X |
Keratoacanthoma | |
Leukemia Mononuclear | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Cerebrum, Meningioma Benign | |
Meninges, Meningioma Benign | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|
DAY ON TEST | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|
| 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + A + + + + + + + + A + + + + + A + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + A + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + A + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + A + + A + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | A + A + A + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + A + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + A + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + A + A + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + A + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|
DAY ON TEST | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|
| 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
C-Cell, Adenoma | |
Follicle, Adenoma | |
Follicular Cell, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + M + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + M + + + + + + + +|
Adenocarcinoma | |
Adenoma | X X X X|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + M + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + M + + + + + + + + + + + + + M + + + + + + + +|
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + A + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|
DAY ON TEST | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|
| 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Benign | |
Fibroma | |
Fibrosarcoma | |
Keratoacanthoma | X|
Leukemia Mononuclear | X |
Squamous Cell Papilloma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + A + + A + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
Cerebrum, Meningioma Benign | |
Meninges, Meningioma Benign | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + A + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + A + | 53 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + A + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + A + | 52 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + A + + A + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + M + + A + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 19 |
Fat, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Adenoma | | 2 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + | 56 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + | 55 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + M + | 59 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 4 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X X X | 17 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + A + + + + + + | 58 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X | 24 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Adenoma | | 1 |
Follicle, Adenoma | | 1 |
Follicular Cell, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + M + + + + | 56 |
Adenocarcinoma | | 1 |
Adenoma | X X | 8 |
Carcinoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Interstitial Cell, Adenoma | X X X X X X X | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + | 56 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M | 59 |
Leukemia Mononuclear | X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 9 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + | 55 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 55 |
Adenoma | | 1 |
Fibroadenoma | | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basosquamous Tumor Benign | | 1 |
Fibroma | | 1 |
Fibrosarcoma | | 1 |
Keratoacanthoma | X | 2 |
Leukemia Mononuclear | | 1 |
Squamous Cell Papilloma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 57 |
Leukemia Mononuclear | | 1 |
Cerebrum, Meningioma Benign | X | 1 |
Meninges, Meningioma Benign | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + M + | 59 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A + + + + + A + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Leukemia Mononuclear | |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicle, Adenoma | X |
Follicle, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | M |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Benign | |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bronchial, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Leukemia Mononuclear | X |
Pancreatic, Lymphoma Malignant | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + M + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X X |
Keratoacanthoma | X |
Neurofibroma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Renal Tubule, Adenoma | X|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant | |
Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A A + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + A + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A A + + + + + A + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A A + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A A + + + + + A + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A A + + + + + A + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + A + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Leukemia Mononuclear | X |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A A + + + + + + + + + |
Adenoma | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A A + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + |
C-Cell, Adenoma | |
Follicle, Adenoma | X |
Follicle, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
Mesothelioma Benign | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + |
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + A + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Benign | X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Bronchial, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Leukemia Mononuclear | |
Pancreatic, Lymphoma Malignant | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + A + + + |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Fibroma | X X |
Keratoacanthoma | X |
Neurofibroma | X |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant | X |
Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + A + + | 42 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + A + + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + | 44 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + | 44 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + | 43 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + | 42 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | A + + + + + + + | 49 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 16 |
Leukemia Mononuclear | | 1 |
Fat, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + | 47 |
Adenoma | | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | A + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + | 47 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | A + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | A + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | A + + + + + + + | 49 |
Leukemia Mononuclear | X X | 3 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | X X | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + | 47 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | A M M + I + + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | A + + + + + + + | 48 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X | 21 |
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + | 48 |
C-Cell, Adenoma | | 1 |
Follicle, Adenoma | | 2 |
Follicle, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Mesothelioma Benign | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 49 |
Adenoma | | 1 |
Carcinoma | X | 3 |
__________________________________________________________________________|____________|
Prostate | A + + + + + + + | 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Testes | A + + + + + + + | 52 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Benign | | 1 |
Interstitial Cell, Adenoma | X X X X X X | 41 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | A + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 1 |
Bronchial, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X | 2 |
Mediastinal, Lymphoma Malignant | X | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Pancreatic, Lymphoma Malignant | X | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | A + + + + + + + | 48 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + + | 49 |
Leukemia Mononuclear | X X | 4 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spleen | A + + + + + + + | 48 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 47 |
Leukemia Mononuclear | X X | 4 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 46 |
Fibroadenoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Fibroma | | 4 |
Keratoacanthoma | X | 3 |
Neurofibroma | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 4 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + | 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant | X | 2 |
Mesothelioma Benign | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | A + + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + + A + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + + A + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + A + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + A + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + M + + + + + + + + + |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + + + + + M +|
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + |
Adenoma | X X |
Leukemia Mononuclear | |
Acinar Cell, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + M + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Leiomyosarcoma, Metastatic | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Leiomyosarcoma | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + A + + + + + + + + + + + M + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Follicle, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fibroma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | A + + + + + + + + + + + + + + + + + M + + + |
Mesothelioma Benign | |
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Prostate | A + + + + + + + + + + + M + + + + + M + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + + + + + + + M + + + + + M + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | |
Mesothelioma Benign | |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + M M + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + M + + + A + + + + + + + + + + M + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | X X |
Lipoma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + M + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | + + + + |
__________________________________________________________________________|
Spinal Cord | + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + M + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + A + + + + M + + + + + M + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Benign | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + + + + + + + + + A + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + A + + A + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + + + + + + + + + A + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
Acinar Cell, Adenoma | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + +|
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fibroma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Benign | X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + M|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M|
Keratoacanthoma | |
Lipoma | X |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Peripheral Nerve | + M + + |
__________________________________________________________________________|
Spinal Cord | + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + A + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + A + | 41 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + A + | 43 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + A + | 44 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + A + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + A + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + A + | 42 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + A + | 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 53 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X | 2 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Mesentery | + + | 11 |
Fat, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + A + + + + | 48 |
Adenoma | | 2 |
Leukemia Mononuclear | | 2 |
Acinar Cell, Adenoma | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Leiomyosarcoma, Metastatic | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 50 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 49 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 49 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Benign | X X | 11 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + | 48 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X | 14 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 49 |
Follicle, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 48 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 46 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 46 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 51 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Benign | | 1 |
Interstitial Cell, Adenoma | X X X X X X | 41 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 44 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 45 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 47 |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M | 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 48 |
Keratoacanthoma | | 2 |
Lipoma | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 46 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 7 |
__________________________________________________________________________|____________|
Spinal Cord | | 8 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 57 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 44 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 8 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|
DAY ON TEST | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|
| 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + A + + + + A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A A A A + + + + + + + + + + + A + A A A + A|
__________________________________________________________________________|
Intestine Large, Colon | + A + A + + A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small | + A + + + A A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + A A A A + + + + + + + + A + + A + A + A A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A A A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leiomyosarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + + |
Leiomyosarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + A + A|
Adenoma | |
Leiomyosarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + M + M M M|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Leukemia | |
Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + A|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + M + M + + M M M|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|
DAY ON TEST | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|
| 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + A + +|
Pars Distalis, Adenoma | X X X X|
__________________________________________________________________________|
Thyroid Gland | + A + + + + M + + + + + + + + + + + + + + + M M M|
C-Cell, Adenoma | |
Follicle, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + A + +|
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + M + M M M|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + A + A|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + A + + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|
DAY ON TEST | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|
| 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + A + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A M +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Fibroma | |
Papilloma | X |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Cortex, Lipoma | |
Renal Tubule, Adenoma | X|
Transitional Epithelium, Carcinoma | X X |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + A + A|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|
| 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A A + + + + + + + + + + + + A + + A A A + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + + + + A + A A A + A A A + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | A A + + + + + + + + + + + + A + + A A A + + A A +|
__________________________________________________________________________|
Intestine Large, Rectum | A A + + + + + + + + + + + + A + + A A A + + A + +|
__________________________________________________________________________|
Intestine Small | A A + + + + + + + + + + + + A + + A A A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + + + + A + + A A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + A + A A A + A A A + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + + + + + A + + A A A + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leiomyosarcoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | + + + + + |
Leiomyosarcoma | X |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + A A + + + A A + + + + +|
Adenoma | X |
Leiomyosarcoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Leukemia | |
Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X X X|
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + A A + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|
| 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M A + + + + + + + + + +|
C-Cell, Adenoma | X |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + M + + + + + + +|
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + M|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|
| 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Fibroma | X |
Papilloma | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Cortex, Lipoma | X |
Renal Tubule, Adenoma | X |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | A A + + + + + + + + + + + + + + + + A A + + A + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + A + + A + A A + A | 42 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + A + A A + A | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + A + A A + A | 40 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + A + A A + A | 42 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + A A + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + A A + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + A + A A + A | 33 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + A A + A | 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Adenoma | | 2 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + A A + A | 48 |
Adenoma | X | 2 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M M + + | 52 |
__________________________________________________________________________|____________|
Stomach | + A + + + + A + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + A + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + A + + + | 53 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Leukemia | | |
Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 3 |
Pheochromocytoma Benign | X X | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A A + A | 52 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + | 56 |
Pars Distalis, Adenoma | X X | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + M M + + | 50 |
C-Cell, Adenoma | | 1 |
Follicle, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + M + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + | 59 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + M + + + + + + + M | 56 |
Interstitial Cell, Adenoma | X X X X X X X X | 46 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + | 56 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + | 58 |
Lumbar, Leukemia Mononuclear | X | 2 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M M + + | 52 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + | 57 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 55 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + | 55 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M + + + + | 53 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + + + | 57 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
__________________________________________________________________________|____________|
Spinal Cord | | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Fibroma | | 1 |
Papilloma | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 2 |
Cortex, Lipoma | | 1 |
Renal Tubule, Adenoma | | 2 |
Transitional Epithelium, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + A A + A | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| | |
| 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Intestine Large | A | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | |
__________________________________________________________________________|____________|
Intestine Large, Colon | A | |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A | |
__________________________________________________________________________|____________|
Intestine Small | A | |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + M M + + + M + + + + | 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| | |
| 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Intestine Large | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + M + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5| | |
| 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
41 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + A A + + A + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A + A + A A + + A + + + + + + + A + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A A + A + A A + + A + + + + + + + A + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + A A + + A + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small | + A A + A + A A + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A + A + A A + + A + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + M + A A + A A + + + + + + + A + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + A + A M + A + + + + + + + + + + | 14 |
Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + A + + + + + + + + + + + + + | 19 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X | 6 |
__________________________________________________________________________|____________|
Mesentery | + + + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + A + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + A + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X X X | 4 |
Schwannoma NOS | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Pheochromocytoma Benign | X X X X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + M + | 18 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + M | 18 |
Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5| | |
| 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
41 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + A + + + + + + + + M + + + + | 18 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + A + + + + + + + + + + | 18 |
Follicle, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + A A + A + + + + + + + + + + | 17 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X | 16 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
Mediastinal, Leukemia Mononuclear | X X | 2 |
Pancreatic, Leukemia Mononuclear | X | 1 |
Renal, Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A M + + + + + + + + + + + + | 18 |
Leukemia Mononuclear | X X X X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X X X X X X | 6 |
__________________________________________________________________________|____________|
Thymus | M + + + + + A + + + + + + + + + + + + + | 18 |
Leukemia Mononuclear | X X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + | 19 |
Fibroadenoma | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5| | |
| 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
41 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroma | X | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X X X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 9 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Interstitial Cell, Adenoma | X X X X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Keratoacanthoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Alveolar/Bronchiolar Adenoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 94
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Adenoma | X X X X X X X | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Bronchiole, Alveolus, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + A + + + + A A | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + A A | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A | 19 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M M + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 4 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Pheochromocytoma Benign | X X X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
Pars Distalis, Adenoma | X X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X | 16 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
Mediastinal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M M + + + + + M M + + + + + + M | 15 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
Basal Cell Adenoma | X X X | 3 |
Fibroma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + M M + + + + + + + + + + | 18 |
Cerebellum, Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Mononuclear | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/07/97
Route: GAVAGE Time: 12:09:01
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + M M + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Renal Tubule, Oncocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 98
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---------- END OF REPORT ----------
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