Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1401

TDMS Study 05091-01 Pathology Tables

NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96
Route: GAVAGE                                                                                                     Time: 10:55:14

                                                      41 WEEK STOP AMINAL




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    25008 Accident                          25004 Dead
                               25003 Moribund                          25006 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 011    600MG/KG 41 STOP

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:55:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5|              |            |
                                           | 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     41 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  A  +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  A  +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  A  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  M  +  A  A  +  A  A  +  +  +  +  +  +  +  A  +               |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  A  +  A  M  +  A  +  +  +  +  +  +  +  +  +  +               |  14        |
      Leiomyoma                            |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Hepatocellular Adenoma               |                                              X                           |          1 |
      Leukemia Mononuclear                 |          X              X           X        X        X  X               |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                                      +                        |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                      +        +     +                                    |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X                          X        X           X               |          4 |
      Schwannoma NOS                       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
      Pheochromocytoma Benign              | X                             X     X           X  X                     |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +               |  18        |
      Adenoma                              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M               |  18        |
      Adenoma                              |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:55:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5|              |            |
                                           | 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     41 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
      Pars Distalis, Adenoma               |                X        X           X  X        X  X                     |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  18        |
      Follicle, Adenoma                    |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                     X                    X               |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  +  +  +  +  +               |  17        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Interstitial Cell, Adenoma           | X  X  X  X        X  X  X  X  X  X  X     X  X  X  X  X                  |         16 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Mediastinal, Leukemia Mononuclear    |                                              X        X                  |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |          1 |
      Renal, Leukemia Mononuclear          |          X                                   X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +               |  19        |
      Leukemia Mononuclear                 |          X                                            X  X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |          X                          X                 X  X               |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |          X              X           X        X        X  X               |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |          X                          X                    X               |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Fibroadenoma                         |                                  X  X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:55:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5|              |            |
                                           | 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     41 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroma                              |                                                 X                        |          1 |
      Squamous Cell Papilloma              |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |                                                       X  X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                     X        X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X                                            X  X               |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X                                               X               |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X              X           X        X        X  X               |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------