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TDMS Study 05091-01 Pathology Tables

NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96
Route: GAVAGE                                                                                                     Time: 10:55:14

                                                      41 WEEK STOP AMINAL




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    25008 Accident                          25004 Dead
                               25003 Moribund                          25006 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 011    600MG/KG 41 STOP

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:55:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5|              |            |
                                           | 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     41 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  A  +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  A  +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  A  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  M  +  A  A  +  A  A  +  +  +  +  +  +  +  A  +               |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  A  +  A  M  +  A  +  +  +  +  +  +  +  +  +  +               |  14        |
      Leiomyoma                            |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Hepatocellular Adenoma               |                                              X                           |          1 |
      Leukemia Mononuclear                 |          X              X           X        X        X  X               |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                                      +                        |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                      +        +     +                                    |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X                          X        X           X               |          4 |
      Schwannoma NOS                       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
      Pheochromocytoma Benign              | X                             X     X           X  X                     |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +               |  18        |
      Adenoma                              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M               |  18        |
      Adenoma                              |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:55:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5|              |            |
                                           | 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     41 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
      Pars Distalis, Adenoma               |                X        X           X  X        X  X                     |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  18        |
      Follicle, Adenoma                    |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                     X                    X               |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  +  +  +  +  +               |  17        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Interstitial Cell, Adenoma           | X  X  X  X        X  X  X  X  X  X  X     X  X  X  X  X                  |         16 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Mediastinal, Leukemia Mononuclear    |                                              X        X                  |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |          1 |
      Renal, Leukemia Mononuclear          |          X                                   X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +               |  19        |
      Leukemia Mononuclear                 |          X                                            X  X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |          X                          X                 X  X               |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |          X              X           X        X        X  X               |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  18        |
      Leukemia Mononuclear                 |          X                          X                    X               |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Fibroadenoma                         |                                  X  X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05091-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/17/96  
Route: GAVAGE                                                                                                     Time: 10:55:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5|              |            |
                                           | 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     A      |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     41 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroma                              |                                                 X                        |          1 |
      Squamous Cell Papilloma              |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
      Leukemia Mononuclear                 |                                                       X  X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                                     X        X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X                                            X  X               |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X                                               X               |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |          X              X           X        X        X  X               |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
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