TDMS Study 05091-01 Pathology Tables
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:55:16
65 WEEK STOP AMINAL
Facility: American Biogenics Corp.
Chemical CAS #: 119-84-6
Lock Date: None
Cage Range: All
Reasons For Removal: 25004 Dead 25003 Moribund
25006 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 014 600MG/KG 65 STOP
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:55:16
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + A + + + + A A | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + A A | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A | 19 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M M + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 4 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Pheochromocytoma Benign | X X X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
Pars Distalis, Adenoma | X X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:55:16
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X | 16 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
Mediastinal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M M + + + + + M M + + + + + + M | 15 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
Basal Cell Adenoma | X X X | 3 |
Fibroma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + M M + + + + + + + + + + | 18 |
Cerebellum, Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Mononuclear | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 05091-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/17/96
Route: GAVAGE Time: 10:55:16
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + M M + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Renal Tubule, Oncocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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