TDMS Study 05091-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DIHYDROCOUMARIN
NTP Experiment-Test: 05091-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/12/94
Route: GAVAGE Time: 08:09:05
Facility: American Biogenics Corp.
Chemical CAS #: 119-84-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 9 10 9
Early Deaths
Gavage Death 2 4 2
Moribund 13 17 20 19
Dead 4 8 4 5
Dosing Accident 1
Accident 2
Survivors
Terminal Sacrifice 31 21 26 23
Animals Examined Microscopically 60 58 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57) (46) (47) (57)
Intestine Small, Ileum (56) (42) (45) (57)
Liver (60) (52) (52) (59)
Fibrous Histiocytoma 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hepatocyte, Adenoma 1 (2%)
Mesentery (7) (5) (4) (6)
Adenocarcinoma, Metastatic, Uterus 1 (20%)
Pancreas (58) (46) (49) (58)
Adenoma 1 (2%)
Salivary Glands (60) (51) (50) (59)
Stomach, Forestomach (60) (49) (50) (58)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (60) (48) (48) (57)
Tongue (2) (1)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (51) (51) (59)
Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (51) (49) (59)
Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Medulla (60) (51) (49) (59)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 5 (10%) 5 (10%) 3 (5%)
Bilateral, Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%)
Islets, Pancreatic (60) (46) (50) (58)
Adenoma 2 (3%) 1 (2%) 1 (2%)
Parathyroid Gland (51) (44) (46) (53)
Adenoma 1 (2%)
Pituitary Gland (59) (49) (52) (59)
Adenoma 1 (2%) 1 (2%)
Pars Distalis, Adenoma 36 (61%) 21 (43%) 27 (52%) 19 (32%)
Thyroid Gland (59) (48) (50) (59)
C-Cell, Adenoma 1 (2%) 4 (8%) 1 (2%) 2 (3%)
Follicle, Adenocarcinoma 1 (2%) 1 (2%)
Follicle, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (57) (50) (50) (59)
Adenocarcinoma 2 (4%) 1 (2%)
Adenoma 3 (5%) 1 (2%) 2 (4%) 1 (2%)
Carcinoma 3 (6%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Ovary (60) (51) (50) (59)
Oviduct (1) (1) (4)
Uterus (60) (54) (55) (60)
Adenocarcinoma 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp 11 (18%) 13 (24%) 9 (16%) 8 (13%)
Sarcoma Stromal 1 (2%)
Cervix, Leiomyoma 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Vagina (5) (3)
Leiomyosarcoma 2 (40%)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1) (1)
Bone Marrow (59) (50) (50) (59)
Lymph Node (60) (51) (52) (59)
Deep Cervical, Histiocytic Sarcoma 1 (2%)
Thoracic, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (58) (51) (49) (58)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (60) (50) (50) (59)
Spleen (60) (49) (49) (58)
Histiocytic Sarcoma 1 (2%)
Thymus (53) (47) (50) (58)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (50) (49) (59)
Adenocarcinoma 1 (2%)
Fibroadenoma 15 (25%) 10 (20%) 22 (45%) 6 (10%)
Skin (60) (51) (50) (59)
Fibroma 1 (2%) 2 (3%)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Keratoacanthoma 2 (4%)
Sarcoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (48) (58)
Cerebellum, Astrocytoma Benign 1 (2%)
Spinal Cord (1) (9) (3) (4)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (52) (50) (59)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Fibrous Histiocytoma 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Page 4
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Nose (60) (51) (50) (59)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Pinna, Fibroma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (50) (50) (58)
Renal Tubule, Adenocarcinoma 1 (2%) 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 1 (2%)
Urinary Bladder (58) (50) (48) (58)
Fibrous Histiocytoma 1 (2%)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(58) *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 10 (17%) 10 (17%) 12 (20%) 12 (20%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 150MG/KG 300MG/KG 600MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 51 46 53 40
Total Primary Neoplasms 88 84 92 74
Total Animals with Benign Neoplasms 46 38 50 32
Total Benign Neoplasms 73 61 76 51
Total Animals with Malignant Neoplasms 15 20 15 16
Total Malignant Neoplasms 15 23 16 23
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 20 10 60 60 60
Scheduled Sacrifice 9 19 10 10 10 10
Early Deaths
Moribund 12 23 26 17
Gavage Death 1 1 1 1 2
Dead 9 13 15 29
Dosing Accident 1
Survivors
Terminal Sacrifice 27 12 8 2
Moribund 1
Natural Death 1
Animals Examined Microscopically 60 20 10 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (10) (42) (41) (34)
Intestine Large, Colon (53) (10) (42) (43) (40)
Intestine Large, Rectum (53) (10) (44) (44) (42)
Intestine Small, Duodenum (52) (10) (44) (45) (43)
Intestine Small, Ileum (51) (10) (43) (42) (33)
Intestine Small, Jejunum (50) (10) (42) (43) (40)
Liver (58) (20) (10) (49) (53) (60)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 2 (4%) 2 (3%)
Leiomyosarcoma 1 (2%)
Mesentery (19) (1) (1) (16) (11) (7)
Leiomyosarcoma 1 (14%)
Pancreas (58) (20) (10) (47) (48) (48)
Adenoma 2 (3%) 5 (11%) 2 (4%) 2 (4%)
Leiomyosarcoma 1 (2%)
Acinar Cell, Adenoma 2 (4%)
Salivary Glands (60) (1) (10) (50) (47) (52)
Stomach, Forestomach (56) (20) (10) (48) (50) (56)
Leiomyosarcoma, Metastatic 1 (2%)
Stomach, Glandular (55) (20) (10) (47) (50) (53)
Leiomyosarcoma 1 (2%)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
Tooth (1)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (20) (10) (50) (50) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (20) (9) (49) (49) (60)
Adrenal Gland, Medulla (59) (20) (9) (49) (49) (60)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 17 (29%) 10 (20%) 11 (22%) 8 (13%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (58) (20) (10) (47) (48) (52)
Adenoma 4 (7%) 1 (10%) 2 (4%) 4 (8%) 1 (2%)
Pituitary Gland (58) (20) (9) (48) (48) (56)
Pars Distalis, Adenoma 24 (41%) 1 (5%) 1 (11%) 21 (44%) 14 (29%) 9 (16%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (59) (20) (10) (48) (49) (50)
C-Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Follicle, Adenoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Follicle, Carcinoma 1 (2%)
Follicular Cell, Adenocarcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
Fibroma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (58) (20) (10) (50) (48) (57)
Preputial Gland (56) (2) (10) (49) (48) (59)
Adenocarcinoma 1 (2%)
Adenoma 8 (14%) 1 (2%) 1 (2%) 1 (2%)
Carcinoma 2 (4%) 1 (50%) 3 (6%) 1 (2%)
Prostate (54) (20) (10) (48) (46) (59)
Seminal Vesicle (58) (20) (10) (49) (46) (59)
Testes (58) (20) (10) (52) (51) (56)
Interstitial Cell, Adenoma 48 (83%) 8 (80%) 41 (79%) 41 (80%) 46 (82%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1) (1)
Bone Marrow (56) (1) (10) (49) (50) (56)
Lymph Node (60) (20) (10) (49) (50) (58)
Lymph Node, Mandibular (59) (20) (10) (48) (44) (52)
Lymph Node, Mesenteric (59) (1) (10) (49) (50) (57)
Spleen (58) (20) (10) (48) (45) (55)
Thymus (55) (1) (10) (47) (47) (55)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (1) (8) (46) (47) (53)
Adenoma 1 (2%)
Fibroadenoma 3 (5%) 2 (4%)
Skin (60) (1) (10) (50) (48) (59)
Basosquamous Tumor Benign 1 (2%)
Fibroma 1 (2%) 4 (8%)
Fibrosarcoma 1 (2%)
Keratoacanthoma 2 (3%) 1 (10%) 3 (6%) 2 (4%)
Lipoma 1 (2%)
Neurofibroma 1 (2%)
Squamous Cell Papilloma 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (1) (10) (50) (50) (60)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57) (20) (10) (49) (46) (57)
Cerebrum, Meningioma Benign 1 (2%)
Meninges, Meningioma Benign 1 (2%)
Spinal Cord (2) (1) (4) (8) (4)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (20) (10) (50) (50) (60)
Alveolar/Bronchiolar Adenoma 2 (3%) 1 (10%) 1 (2%) 1 (2%)
Trachea (60) (1) (10) (50) (50) (58)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (2)
Fibroma 1 (50%)
Papilloma 1 (50%)
Zymbal's Gland (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (20) (10) (58) (57) (60)
Cortex, Lipoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 2 (3%)
Transitional Epithelium, Carcinoma 2 (3%)
Urinary Bladder (58) (20) (10) (48) (44) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(20) *(10) *(60) *(60) *(60)
Leukemia Mononuclear 10 (17%) 5 (8%) 8 (13%) 4 (7%)
Lymphoma Malignant 2 (3%)
Mesothelioma Benign 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0 MG/KG 0 MG/KG 150MG/KG 300MG/KG 600MG/KG
CONTROL 39 KILL 65 KILL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 54 2 9 49 51 49
Total Primary Neoplasms 136 2 12 112 97 87
Total Animals with Benign Neoplasms 54 1 9 48 50 48
Total Benign Neoplasms 120 1 12 100 86 77
Total Animals with Malignant Neoplasms 16 1 12 11 8
Total Malignant Neoplasms 16 1 12 11 10
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 20 20 10 20
Scheduled Sacrifice 19 10
Early Deaths
Gavage Death 1
Moribund 6 10
Dead 5 8
Accident 1
Survivors
Dead 1
Terminal Sacrifice 7 2
Animals Examined Microscopically 20 20 10 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (1) (14) (9) (19)
Leiomyoma 1 (7%)
Liver (20) (19) (10) (19)
Hepatocellular Adenoma 1 (5%)
Pancreas (20) (19) (10) (20)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (20) (10) (20)
Schwannoma NOS 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (20) (20) (10) (20)
Osteosarcoma, Metastatic, Bone 1 (5%)
Adrenal Gland, Medulla (19) (20) (10) (20)
Osteosarcoma, Metastatic, Bone 1 (5%)
Pheochromocytoma Benign 5 (25%) 4 (20%)
Islets, Pancreatic (20) (18) (10) (20)
Adenoma 1 (6%) 1 (5%)
Parathyroid Gland (20) (18) (10) (18)
Adenoma 1 (6%)
Pituitary Gland (20) (18) (10) (18)
Pars Distalis, Adenoma 6 (33%) 3 (17%)
Thyroid Gland (20) (18) (10) (18)
Follicle, Adenoma 1 (6%)
Page 12
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Prostate (20) (20) (10) (20)
Seminal Vesicle (20) (17) (10) (20)
Testes (20) (20) (10) (20)
Interstitial Cell, Adenoma 16 (80%) 7 (70%) 16 (80%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (1) (19) (10) (20)
Lymph Node (20) (20) (10) (20)
Lymph Node, Mandibular (20) (19) (10) (18)
Lymph Node, Mesenteric (2) (18) (10) (20)
Spleen (20) (19) (10) (20)
Thymus (1) (18) (10) (19)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (1) (19) (9) (15)
Fibroadenoma 2 (11%)
Skin (2) (20) (10) (20)
Basal Cell Adenoma 3 (15%)
Fibroma 1 (5%) 2 (10%)
Squamous Cell Papilloma 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (20) (10) (20)
Osteosarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (19) (10) (18)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (20) (20) (10) (20)
Alveolar/Bronchiolar Adenoma 1 (5%)
Osteosarcoma, Metastatic, Bone 1 (5%)
Bronchiole, Alveolus, Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (20) (10) (20)
Osteosarcoma, Metastatic, Bone 1 (5%)
Renal Tubule, Oncocytoma Benign 1 (5%)
Urinary Bladder (20) (20) (10) (20)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(20) *(20) *(10) *(20)
Leukemia Mononuclear 6 (30%) 2 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 14
NTP Experiment-Test: 05091-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIHYDROCOUMARIN Date: 09/12/94
Route: GAVAGE Time: 08:09:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 600MG/KG 600MG/KG 600MG/KG 600MG/KG
39 KILL 41 STOP 65 KILL 65 STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 19 7 18
Total Primary Neoplasms 43 9 34
Total Animals with Benign Neoplasms 18 7 17
Total Benign Neoplasms 36 9 31
Total Animals with Malignant Neoplasms 6 3
Total Malignant Neoplasms 6 3
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 15
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