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https://ntp.niehs.nih.gov/go/1407

TDMS Study 05091-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          DIHYDROCOUMARIN


NTP Experiment-Test: 05091-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 08:09:05




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10            9                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       2            4                         2                                     
    Moribund                                          13           17           20           19                                     
    Dead                                               4            8            4            5                                     
    Dosing Accident                                                 1                                                               
    Accident                                                                                  2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           21           26           23                                     
  Animals Examined Microscopically                    60           58           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)         (46)         (47)         (57)                                   
   Intestine Small, Ileum                             (56)         (42)         (45)         (57)                                   
   Liver                                              (60)         (52)         (52)         (59)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hepatocyte, Adenoma                                                                     1 (2%)                                
   Mesentery                                          (7)          (5)          (4)          (6)                                    
      Adenocarcinoma, Metastatic, Uterus                            1 (20%)                                                         
   Pancreas                                           (58)         (46)         (49)         (58)                                   
      Adenoma                                                                    1 (2%)                                             
   Salivary Glands                                    (60)         (51)         (50)         (59)                                   
   Stomach, Forestomach                               (60)         (49)         (50)         (58)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (48)         (48)         (57)                                   
   Tongue                                                          (2)          (1)                                                 
      Squamous Cell Papilloma                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (51)         (51)         (59)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (51)         (49)         (59)                                   
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (60)         (51)         (49)         (59)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)       5 (10%)      5 (10%)      3 (5%)                                
      Bilateral, Pheochromocytoma Benign                            2 (4%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (46)         (50)         (58)                                   
      Adenoma                                          2 (3%)                    1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (51)         (44)         (46)         (53)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (59)         (49)         (52)         (59)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Pars Distalis, Adenoma                          36 (61%)     21 (43%)     27 (52%)     19 (32%)                               
   Thyroid Gland                                      (59)         (48)         (50)         (59)                                   
      C-Cell, Adenoma                                  1 (2%)       4 (8%)       1 (2%)       2 (3%)                                
      Follicle, Adenocarcinoma                                                   1 (2%)       1 (2%)                                
      Follicle, Adenoma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (50)         (50)         (59)                                   
      Adenocarcinoma                                   2 (4%)       1 (2%)                                                          
      Adenoma                                          3 (5%)       1 (2%)       2 (4%)       1 (2%)                                
      Carcinoma                                                     3 (6%)                    1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Ovary                                              (60)         (51)         (50)         (59)                                   
   Oviduct                                            (1)          (1)                       (4)                                    
   Uterus                                             (60)         (54)         (55)         (60)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Leiomyoma                                        1 (2%)                                                                       
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp                                           11 (18%)     13 (24%)      9 (16%)      8 (13%)                               
      Sarcoma Stromal                                                                         1 (2%)                                
      Cervix, Leiomyoma                                             1 (2%)                                                          
      Cervix, Sarcoma Stromal                                                                 1 (2%)                                
   Vagina                                                          (5)                       (3)                                    
      Leiomyosarcoma                                                2 (40%)                                                         
      Sarcoma                                                                                 1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (1)                       (1)                                    
   Bone Marrow                                        (59)         (50)         (50)         (59)                                   
   Lymph Node                                         (60)         (51)         (52)         (59)                                   
      Deep Cervical, Histiocytic Sarcoma               1 (2%)                                                                       
      Thoracic, Histiocytic Sarcoma                    1 (2%)                                                                       
   Lymph Node, Mandibular                             (58)         (51)         (49)         (58)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (60)         (50)         (50)         (59)                                   
   Spleen                                             (60)         (49)         (49)         (58)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (53)         (47)         (50)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (50)         (49)         (59)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Fibroadenoma                                    15 (25%)     10 (20%)     22 (45%)      6 (10%)                               
   Skin                                               (60)         (51)         (50)         (59)                                   
      Fibroma                                                                    1 (2%)       2 (3%)                                
      Fibrous Histiocytoma                                          1 (2%)                    1 (2%)                                
      Keratoacanthoma                                                            2 (4%)                                             
      Sarcoma                                          1 (2%)       1 (2%)                                                          
      Squamous Cell Papilloma                                                                 2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (48)         (58)                                   
      Cerebellum, Astrocytoma Benign                                                          1 (2%)                                
   Spinal Cord                                        (1)          (9)          (3)          (4)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (50)         (59)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
                                                             Page   4                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
   Nose                                               (60)         (51)         (50)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Pinna, Fibroma                                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (50)         (58)                                   
      Renal Tubule, Adenocarcinoma                                  1 (2%)       1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (58)         (50)         (48)         (58)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Papilloma                                                                               1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(58)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            10 (17%)     10 (17%)     12 (20%)     12 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      150MG/KG     300MG/KG     600MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            51          46          53          40                                       
     Total Primary Neoplasms                           88          84          92          74                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          38          50          32                                       
     Total Benign Neoplasms                            73          61          76          51                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          20          15          16                                       
     Total Malignant Neoplasms                         15          23          16          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2                                                               
     Total Metastatic Neoplasm                          1           3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           20           10           60           60           60           
  Scheduled Sacrifice                                  9           19           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund                                          12                                     23           26           17           
    Gavage Death                                       1            1                         1            1            2           
    Dead                                               9                                     13           15           29           
    Dosing Accident                                    1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                27                                     12            8            2           
    Moribund                                                                                  1                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    60           20           10           60           60           60           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)                      (10)         (42)         (41)         (34)         
   Intestine Large, Colon                             (53)                      (10)         (42)         (43)         (40)         
   Intestine Large, Rectum                            (53)                      (10)         (44)         (44)         (42)         
   Intestine Small, Duodenum                          (52)                      (10)         (44)         (45)         (43)         
   Intestine Small, Ileum                             (51)                      (10)         (43)         (42)         (33)         
   Intestine Small, Jejunum                           (50)                      (10)         (42)         (43)         (40)         
   Liver                                              (58)         (20)         (10)         (49)         (53)         (60)         
      Hepatocellular Carcinoma                                                                             1 (2%)                   
      Hepatocellular Adenoma                                                                  1 (2%)       2 (4%)       2 (3%)      
      Leiomyosarcoma                                                                                                    1 (2%)      
   Mesentery                                          (19)         (1)          (1)          (16)         (11)         (7)          
      Leiomyosarcoma                                                                                                    1 (14%)     
   Pancreas                                           (58)         (20)         (10)         (47)         (48)         (48)         
      Adenoma                                          2 (3%)                                 5 (11%)      2 (4%)       2 (4%)      
      Leiomyosarcoma                                                                                                    1 (2%)      
      Acinar Cell, Adenoma                                                                                 2 (4%)                   
   Salivary Glands                                    (60)         (1)          (10)         (50)         (47)         (52)         
   Stomach, Forestomach                               (56)         (20)         (10)         (48)         (50)         (56)         
      Leiomyosarcoma, Metastatic                                                                           1 (2%)                   
   Stomach, Glandular                                 (55)         (20)         (10)         (47)         (50)         (53)         
      Leiomyosarcoma                                                                                       1 (2%)                   
   Tongue                                                                                    (1)                       (1)          
      Squamous Cell Papilloma                                                                 1 (100%)                  1 (100%)    
   Tooth                                                                                                               (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (20)         (10)         (50)         (50)         (60)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (20)         (9)          (49)         (49)         (60)         
   Adrenal Gland, Medulla                             (59)         (20)         (9)          (49)         (49)         (60)         
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                         17 (29%)                               10 (20%)     11 (22%)      8 (13%)     
      Bilateral, Pheochromocytoma Benign                                                                   1 (2%)                   
   Islets, Pancreatic                                 (58)         (20)         (10)         (47)         (48)         (52)         
      Adenoma                                          4 (7%)                    1 (10%)      2 (4%)       4 (8%)       1 (2%)      
   Pituitary Gland                                    (58)         (20)         (9)          (48)         (48)         (56)         
      Pars Distalis, Adenoma                          24 (41%)      1 (5%)       1 (11%)     21 (44%)     14 (29%)      9 (16%)     
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (59)         (20)         (10)         (48)         (49)         (50)         
      C-Cell, Adenoma                                  1 (2%)                                 1 (2%)                    1 (2%)      
      Follicle, Adenoma                                1 (2%)                                 2 (4%)       1 (2%)       1 (2%)      
      Follicle, Carcinoma                                                                     1 (2%)                                
      Follicular Cell, Adenocarcinoma                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)          (1)          (1)          
      Fibroma                                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)         (20)         (10)         (50)         (48)         (57)         
   Preputial Gland                                    (56)         (2)          (10)         (49)         (48)         (59)         
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenoma                                          8 (14%)                                1 (2%)       1 (2%)       1 (2%)      
      Carcinoma                                        2 (4%)       1 (50%)                   3 (6%)                    1 (2%)      
   Prostate                                           (54)         (20)         (10)         (48)         (46)         (59)         
   Seminal Vesicle                                    (58)         (20)         (10)         (49)         (46)         (59)         
   Testes                                             (58)         (20)         (10)         (52)         (51)         (56)         
      Interstitial Cell, Adenoma                      48 (83%)                   8 (80%)     41 (79%)     41 (80%)     46 (82%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                                     (1)          (1)          (1)          
   Bone Marrow                                        (56)         (1)          (10)         (49)         (50)         (56)         
   Lymph Node                                         (60)         (20)         (10)         (49)         (50)         (58)         
   Lymph Node, Mandibular                             (59)         (20)         (10)         (48)         (44)         (52)         
   Lymph Node, Mesenteric                             (59)         (1)          (10)         (49)         (50)         (57)         
   Spleen                                             (58)         (20)         (10)         (48)         (45)         (55)         
   Thymus                                             (55)         (1)          (10)         (47)         (47)         (55)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (1)          (8)          (46)         (47)         (53)         
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                     3 (5%)                                 2 (4%)                                
   Skin                                               (60)         (1)          (10)         (50)         (48)         (59)         
      Basosquamous Tumor Benign                        1 (2%)                                                                       
      Fibroma                                          1 (2%)                                 4 (8%)                                
      Fibrosarcoma                                     1 (2%)                                                                       
      Keratoacanthoma                                  2 (3%)                    1 (10%)      3 (6%)       2 (4%)                   
      Lipoma                                                                                               1 (2%)                   
      Neurofibroma                                                                            1 (2%)                                
      Squamous Cell Papilloma                          2 (3%)                                 1 (2%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (1)          (10)         (50)         (50)         (60)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)         (20)         (10)         (49)         (46)         (57)         
      Cerebrum, Meningioma Benign                      1 (2%)                                                                       
      Meninges, Meningioma Benign                      1 (2%)                                                                       
   Spinal Cord                                        (2)          (1)                       (4)          (8)          (4)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (20)         (10)         (50)         (50)         (60)         
      Alveolar/Bronchiolar Adenoma                     2 (3%)                    1 (10%)      1 (2%)       1 (2%)                   
   Trachea                                            (60)         (1)          (10)         (50)         (50)         (58)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)          (1)          (2)          
      Fibroma                                                                                                           1 (50%)     
      Papilloma                                                                                                         1 (50%)     
   Zymbal's Gland                                                                                         (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (20)         (10)         (58)         (57)         (60)         
      Cortex, Lipoma                                                                                                    1 (2%)      
      Renal Tubule, Adenoma                                                                   1 (2%)                    2 (3%)      
      Transitional Epithelium, Carcinoma                                                                                2 (3%)      
   Urinary Bladder                                    (58)         (20)         (10)         (48)         (44)         (48)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(20)        *(10)        *(60)        *(60)        *(60)         
      Leukemia Mononuclear                            10 (17%)                                5 (8%)       8 (13%)      4 (7%)      
      Lymphoma Malignant                                                                      2 (3%)                                
      Mesothelioma Benign                                                                     2 (3%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      150MG/KG     300MG/KG     600MG/KG        
                                                   CONTROL      39 KILL       65 KILL                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            54           2           9          49          51          49               
     Total Primary Neoplasms                          136           2          12         112          97          87               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 54           1           9          48          50          48               
     Total Benign Neoplasms                           120           1          12         100          86          77               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16           1                      12          11           8               
     Total Malignant Neoplasms                         16           1                      12          11          10               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                              1                           
     Total Metastatic Neoplasm                                                                          1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          20           20           10           20                                     
  Scheduled Sacrifice                                 19                        10                                                  
  Early Deaths                                                                                                                      
    Gavage Death                                       1                                                                            
    Moribund                                                        6                        10                                     
    Dead                                                            5                         8                                     
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Dead                                                            1                                                               
    Terminal Sacrifice                                              7                         2                                     
  Animals Examined Microscopically                    20           20           10           20                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (1)          (14)         (9)          (19)                                   
      Leiomyoma                                                     1 (7%)                                                          
   Liver                                              (20)         (19)         (10)         (19)                                   
      Hepatocellular Adenoma                                        1 (5%)                                                          
   Pancreas                                           (20)         (19)         (10)         (20)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (20)         (10)         (20)                                   
      Schwannoma NOS                                                1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (20)         (10)         (20)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (5%)                                
   Adrenal Gland, Medulla                             (19)         (20)         (10)         (20)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (5%)                                
      Pheochromocytoma Benign                                       5 (25%)                   4 (20%)                               
   Islets, Pancreatic                                 (20)         (18)         (10)         (20)                                   
      Adenoma                                                       1 (6%)                    1 (5%)                                
   Parathyroid Gland                                  (20)         (18)         (10)         (18)                                   
      Adenoma                                                       1 (6%)                                                          
   Pituitary Gland                                    (20)         (18)         (10)         (18)                                   
      Pars Distalis, Adenoma                                        6 (33%)                   3 (17%)                               
   Thyroid Gland                                      (20)         (18)         (10)         (18)                                   
      Follicle, Adenoma                                             1 (6%)                                                          
                                                             Page  12                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                                                   1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (20)         (20)         (10)         (20)                                   
   Seminal Vesicle                                    (20)         (17)         (10)         (20)                                   
   Testes                                             (20)         (20)         (10)         (20)                                   
      Interstitial Cell, Adenoma                                   16 (80%)      7 (70%)     16 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (1)          (19)         (10)         (20)                                   
   Lymph Node                                         (20)         (20)         (10)         (20)                                   
   Lymph Node, Mandibular                             (20)         (19)         (10)         (18)                                   
   Lymph Node, Mesenteric                             (2)          (18)         (10)         (20)                                   
   Spleen                                             (20)         (19)         (10)         (20)                                   
   Thymus                                             (1)          (18)         (10)         (19)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)          (19)         (9)          (15)                                   
      Fibroadenoma                                                  2 (11%)                                                         
   Skin                                               (2)          (20)         (10)         (20)                                   
      Basal Cell Adenoma                                                                      3 (15%)                               
      Fibroma                                                       1 (5%)                    2 (10%)                               
      Squamous Cell Papilloma                                       1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (1)          (20)         (10)         (20)                                   
      Osteosarcoma                                                                            1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  13                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (19)         (10)         (18)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (20)         (10)         (20)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (5%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (5%)                                
      Bronchiole, Alveolus, Adenoma                                              1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (10)         (20)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (5%)                                
      Renal Tubule, Oncocytoma Benign                                                         1 (5%)                                
   Urinary Bladder                                    (20)         (20)         (10)         (20)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(20)        *(20)        *(10)        *(20)                                   
      Leukemia Mononuclear                                          6 (30%)                   2 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05091-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          DIHYDROCOUMARIN                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 08:09:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     600MG/KG     600MG/KG     600MG/KG     600MG/KG                                  
                                                    39 KILL      41 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)                        19           7          18                                       
     Total Primary Neoplasms                                       43           9          34                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                             18           7          17                                       
     Total Benign Neoplasms                                        36           9          31                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           6                       3                                       
     Total Malignant Neoplasms                                      6                       3                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                  1                                       
     Total Metastatic Neoplasm                                                              4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
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                             ----------              END OF REPORT             ----------                                           
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