TDMS Study 05091-01 Pathology Tables
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
Facility: American Biogenics Corp.
Chemical CAS #: 119-84-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|
| 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 2 2 |
Clear Cell Focus | 1 1 |
Developmental Malformation | X X |
Fatty Change | 2 |
Inflammation, Chronic | 1 2 1 2 1 2 2 3 1 2 2 |
Bile Duct, Hyperplasia | 1 1 2|
Central Vein, Dilatation | |
Hepatocyte, Hyperplasia | |
Periductular, Fibrosis | |
Periductular, Inflammation, Chronic | |
Sinusoid, Dilatation | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Coagulative | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periductular, Infiltration Cellular, | |
Lymphocyte | |
Submandibular Gland, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Mineralization | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|
| 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 3 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cyst | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + M + M + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst Multilocular | 2 |
Pars Distalis, Hyperplasia | 2 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
Follicle, Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrometra | 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prefemoral, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|
| 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Depletion Lymphoid | |
Fibrosis | 3 |
Necrosis, Liquifactive | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + + + + + + + + + + M +|
Epithelial Cell, Cyst | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X 3 |
Lactation | |
Acinus, Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 3 |
Hypothalamus, Compression | |
Meninges, Inflammation, Chronic | 2 |
Thalamus, Compression | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Edema | 3 |
Alveolus, Hemorrhage | 2 |
Alveolus, Inflammation, Chronic | 1 2 1 2 2 2 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | 2 3 |
Lumen, Inflammation, Chronic | 2 |
Lumen, Inflammation, Suppurative | 3 2 |
Mucosa, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|
| 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1|
Collecting Tubule, Mineralization | |
Cortex, Cyst | |
Cortex, Necrosis, Coagulative | 3 |
Interstitium, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|
| 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | |
Developmental Malformation | X X X X X|
Fatty Change | 2 |
Inflammation, Chronic | 3 1 2 2 2 1 2 2 1|
Bile Duct, Hyperplasia | 2 2|
Central Vein, Dilatation | 1 |
Hepatocyte, Hyperplasia | 2 |
Periductular, Fibrosis | 2 |
Periductular, Inflammation, Chronic | 2 2 3 1 |
Sinusoid, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic | 2 |
Fat, Necrosis, Coagulative | 2 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periductular, Infiltration Cellular, | |
Lymphocyte | 2 |
Submandibular Gland, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Mineralization | 3 1 |
Ulcer | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|
| 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 2|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
Cyst | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 1 1 1 1 1 1 |
Infiltration Cellular, Lymphocyte | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + M + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 |
Pars Distalis, Cyst Multilocular | X 2 3 |
Pars Distalis, Hyperplasia | |
Pars Nervosa, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 4 2 |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 2 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 4 3 3 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prefemoral, Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|
| 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 2 |
Depletion Lymphoid | 1 |
Fibrosis | |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Epithelial Cell, Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Galactocele | |
Lactation | 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
Hypothalamus, Compression | 4 |
Meninges, Inflammation, Chronic | |
Thalamus, Compression | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Edema | |
Alveolus, Hemorrhage | |
Alveolus, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | |
Lumen, Inflammation, Chronic | |
Lumen, Inflammation, Suppurative | |
Mucosa, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|
| 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
VEHICLE | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 2 1 1 1 1 1 |
Collecting Tubule, Mineralization | 1 |
Cortex, Cyst | 3 |
Cortex, Necrosis, Coagulative | |
Interstitium, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6| | |
| 1| 0| 9| 0| 2| 4| 5| 1| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + A + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + A + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 3 2.0|
Clear Cell Focus | 2 | 3 1.3|
Developmental Malformation | X | 8 |
Fatty Change | 2 | 3 2.0|
Inflammation, Chronic | 1 1 2 | 23 1.7|
Bile Duct, Hyperplasia | 2 | 6 1.7|
Central Vein, Dilatation | | 1 1.0|
Hepatocyte, Hyperplasia | | 1 2.0|
Periductular, Fibrosis | | 1 2.0|
Periductular, Inflammation, Chronic | | 4 2.0|
Sinusoid, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Inflammation, Chronic | | 1 2.0|
Fat, Necrosis, Coagulative | | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + | 58 |
Atrophy | | 2 1.5|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Periductular, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Submandibular Gland, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6| | |
| 1| 0| 9| 0| 2| 4| 5| 1| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 1 | 13 1.7|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Clear Cell Focus | | 1 2.0|
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Cyst | | 1 3.0|
Hyperplasia | 1 1 1 | 9 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Cyst | 2 | 4 2.3|
Pars Distalis, Cyst Multilocular | 2 2 | 6 2.2|
Pars Distalis, Hyperplasia | | 1 2.0|
Pars Nervosa, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 6 2.0|
Follicle, Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + M + | 57 |
Hyperplasia | | 2 3.0|
Inflammation, Suppurative | 4 | 3 3.3|
Duct, Dilatation | | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Follicle, Cyst | | 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6| | |
| 1| 0| 9| 0| 2| 4| 5| 1| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Hydrometra | | 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Prefemoral, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 2 2.5|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | 4 | 1 4.0|
Congestion | | 1 2.0|
Depletion Lymphoid | | 1 1.0|
Fibrosis | | 1 3.0|
Necrosis, Liquifactive | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + M | 53 |
Epithelial Cell, Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Galactocele | | 3 3.0|
Lactation | | 1 2.0|
Acinus, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 1 3.0|
Hypothalamus, Compression | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6| | |
| 1| 0| 9| 0| 2| 4| 5| 1| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | A |
VEHICLE | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Meninges, Inflammation, Chronic | | 1 2.0|
Thalamus, Compression | | 2 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia | 3 | 3 2.0|
Alveolus, Edema | | 1 3.0|
Alveolus, Hemorrhage | | 1 2.0|
Alveolus, Inflammation, Chronic | | 10 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Lumen, Fungus | | 2 2.5|
Lumen, Inflammation, Chronic | | 1 2.0|
Lumen, Inflammation, Suppurative | 2 | 3 2.3|
Mucosa, Inflammation, Chronic Active | 4 | 1 4.0|
Mucosa, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 4 | 1 4.0|
Retina, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 2 | 22 1.1|
Collecting Tubule, Mineralization | | 1 1.0|
Cortex, Cyst | | 1 3.0|
Cortex, Necrosis, Coagulative | | 1 3.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + M + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|
DAY ON TEST | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|
| 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + + + + + + + + + + A + + + + A|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + A + + + + M|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 |
Clear Cell Focus | 1 |
Developmental Malformation | X X X X X |
Eosinophilic Focus | |
Fatty Change | 1 |
Inflammation, Chronic | 2 2 1 2 3 1 2 2 |
Necrosis, Coagulative | 2 3 1 3 |
Bile Duct, Hyperplasia | |
Centrilobular, Necrosis, Coagulative | 1 |
Hepatocyte, Hyperplasia | 2 |
Periductular, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + A|
Atrophy | 2 2 1 |
Ectopic Tissue | X |
Hemorrhage, Chronic | 2 |
Hyperplasia | |
Inflammation, Chronic | 2 1 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|
DAY ON TEST | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|
| 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 4 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + A|
Infiltration Cellular, Lymphocyte | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A|
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Cyst Multilocular | |
Pars Distalis, Cytoplasmic Alteration| 1 |
Pars Distalis, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Inflammation, Suppurative | 4 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 4 3 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 3 |
Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Vagina | + + |
Hyperkeratosis | 3 |
Hyperplasia, Squamous | |
Inflammation, Suppurative | |
Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|
DAY ON TEST | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|
| 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Hemorrhage | |
Mediastinal, Necrosis, Coagulative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A|
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
Hyperplasia, Reticulum Cell | |
Necrosis, Coagulative | |
Capsule, Hemorrhage | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + M + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + A|
Galactocele | |
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 |
Hydrocephalus | |
Necrosis, Liquifactive | 3 |
Thalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + + M + |
__________________________________________________________________________|
Spinal Cord | + I + + + M |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2|
Edema | |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|
DAY ON TEST | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|
| 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Inflammation, Chronic | 2 |
Alveolus, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Lacrimal Gland | |
Pigmentation, Porphyrin | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A|
Hydronephrosis | 4 |
Nephropathy | 1 1 1 1 2 1 1 |
Pelvis, Inflammation, Chronic | 2 |
Pelvis, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|
| 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
150MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + A + + + A + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + A + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 1 2 |
Clear Cell Focus | |
Developmental Malformation | X |
Eosinophilic Focus | 2 |
Fatty Change | 1 2 2 2 |
Inflammation, Chronic | 2 2 2 1 1 1 2|
Necrosis, Coagulative | 3 4 1 |
Bile Duct, Hyperplasia | 3 4 2 3 |
Centrilobular, Necrosis, Coagulative | 3 |
Hepatocyte, Hyperplasia | |
Periductular, Fibrosis | 3 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | 2 |
Fat, Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Pancreas | + + + A A + + + A + + + + + + + + + + + + +|
Atrophy | 2 2 1 |
Ectopic Tissue | |
Hemorrhage, Chronic | |
Hyperplasia | 3 2 |
Inflammation, Chronic | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + A + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|
| 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
150MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 3 2 2 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A A + + + A + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + M M M + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + A + + + + + A + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 3 |
Pars Distalis, Cyst Multilocular | 2 2 3 2 |
Pars Distalis, Cytoplasmic Alteration| |
Pars Distalis, Hemorrhage | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + A + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 3 2 4 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | + + + |
Hyperkeratosis | |
Hyperplasia, Squamous | 4 |
Inflammation, Suppurative | 4 4 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|
| 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
150MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
Hyperplasia, Reticulum Cell | 2 |
Necrosis, Coagulative | 4 |
Capsule, Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Lactation | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + A + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
Necrosis, Liquifactive | |
Thalamus, Compression | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + |
__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 3 2 |
Alveolar Epithelium, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|
| 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
150MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Inflammation, Chronic | |
Alveolus, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Lacrimal Gland | + |
Pigmentation, Porphyrin | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Nephropathy | 1 1 1 1 1 2 1 1 1 1|
Pelvis, Inflammation, Chronic | |
Pelvis, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 43 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 52 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 4 1.5|
Clear Cell Focus | | 1 1.0|
Developmental Malformation | | 6 |
Eosinophilic Focus | | 1 2.0|
Fatty Change | 4 3 | 7 2.1|
Inflammation, Chronic | 2 1 2 | 18 1.7|
Necrosis, Coagulative | | 7 2.4|
Bile Duct, Hyperplasia | 2 | 5 2.8|
Centrilobular, Necrosis, Coagulative | | 2 2.0|
Hepatocyte, Hyperplasia | | 1 2.0|
Periductular, Fibrosis | 2 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Inflammation, Chronic | | 2 2.5|
Fat, Necrosis, Coagulative | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 46 |
Atrophy | 1 | 7 1.6|
Ectopic Tissue | | 1 |
Hemorrhage, Chronic | | 1 2.0|
Hyperplasia | | 2 2.5|
Inflammation, Chronic | | 3 1.7|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 48 |
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 2 |
Hyperkeratosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 51 |
Cardiomyopathy | 3 | 16 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 51 |
Necrosis, Coagulative | | 1 4.0|
Vacuolization Cytoplasmic | | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 51 |
Hyperplasia | | 10 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 46 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 49 |
Pars Distalis, Cyst | 2 | 6 2.2|
Pars Distalis, Cyst Multilocular | | 4 2.3|
Pars Distalis, Cytoplasmic Alteration| | 1 1.0|
Pars Distalis, Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 48 |
C-Cell, Hyperplasia | 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 50 |
Hyperplasia | 2 | 4 2.5|
Inflammation, Suppurative | | 4 3.3|
Duct, Dilatation | 2 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 51 |
Follicle, Cyst | 3 | 4 3.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 54 |
Hydrometra | 4 3 | 6 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | | 2 2.5|
__________________________________________________________________________|____________|
Vagina | | 5 |
Hyperkeratosis | | 1 3.0|
Hyperplasia, Squamous | | 1 4.0|
Inflammation, Suppurative | | 2 4.0|
Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 51 |
Inguinal, Hyperplasia, Plasma Cell | | 1 4.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 51 |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 49 |
Hematopoietic Cell Proliferation | | 2 2.5|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Hyperplasia, Reticulum Cell | | 1 2.0|
Necrosis, Coagulative | | 1 4.0|
Capsule, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 50 |
Galactocele | 3 | 2 3.0|
Lactation | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 51 |
Inflammation, Suppurative | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 5| 7| 4| 4| 4| | |
DAY ON TEST | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6| | |
| 4| 1| 8| 5| 1| 3| 1| 1| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
150MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Hemorrhage | | 2 2.0|
Hydrocephalus | 3 | 1 3.0|
Necrosis, Liquifactive | | 1 3.0|
Thalamus, Compression | 3 | 2 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 9 |
__________________________________________________________________________|____________|
Spinal Cord | | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 52 |
Congestion | | 2 2.0|
Edema | | 2 2.5|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.8|
Alveolus, Inflammation, Chronic | | 1 2.0|
Alveolus, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 51 |
Lumen, Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Pigmentation, Porphyrin | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Hydronephrosis | | 2 3.5|
Nephropathy | 1 1 1 1 | 21 1.1|
Pelvis, Inflammation, Chronic | | 1 2.0|
Pelvis, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|
| 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 1 |
Congestion | 2 |
Developmental Malformation | X X |
Fatty Change | 2 1 |
Inflammation, Chronic | 2 1 1 1 1 2 2 2 2 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 1 2 |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Hyperplasia | 2 2 |
Periductular, Fibrosis | 1 |
Periductular, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Coagulative | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Ectopic Tissue | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 3 |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Mucosa, Dilatation | 2 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|
| 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 2 2 1|
Atrioventricular Valve, Fibrosis | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Infarct | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 |
Pars Distalis, Cyst Multilocular | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 |
Pars Intermedia, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 |
Follicle, Cyst | 2 |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 2 3 3 |
Duct, Dilatation | |
Duct, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 3 |
Hyperplasia, Cystic | 3 2 3 |
Cervix, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|
| 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Lumbar, Pigmentation, Hemosiderin | |
Mediastinal, Hyperplasia, Macrophage | |
Prefemoral, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + +|
Galactocele | |
Lactation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + A|
Hydrocephalus | |
Hypothalamus, Compression | 3 |
Thalamus, Compression | 3 |
Thalamus, Necrosis, Coagulative | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | |
Lumen, Inflammation, Suppurative | |
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|
| 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Iris, Synechia | 4 |
Lens, Cataract | |
Posterior Chamber, Hemorrhage | |
Retina, Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 2 1 1 2 2 1 1 1 1 2 1 2|
Cortex, Cyst | |
Pelvis, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|
| 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
300MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 3 2 |
Congestion | |
Developmental Malformation | X X |
Fatty Change | 1 3 1 3 |
Inflammation, Chronic | 2 1 1 2 2 1 1 3 |
Mixed Cell Focus | |
Necrosis, Coagulative | 2 2 |
Bile Duct, Hyperplasia | 2 2 3 |
Hepatocyte, Hyperplasia | |
Periductular, Fibrosis | |
Periductular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Ectopic Tissue | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation, Suppurative | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 |
Mucosa, Dilatation | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|
| 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
300MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 2 2 1 2 2 1 |
Atrioventricular Valve, Fibrosis | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | 4 |
Infarct | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Cyst Multilocular | 2 |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
Pars Intermedia, Hemorrhage | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
Follicle, Cyst | |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 4 3 |
Duct, Dilatation | 3 3 |
Duct, Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 4 3|
Hyperplasia, Cystic | 2 2 4 |
Cervix, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|
| 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
300MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Lumbar, Pigmentation, Hemosiderin | 2 |
Mediastinal, Hyperplasia, Macrophage | 2 |
Prefemoral, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 4 X |
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Hypothalamus, Compression | |
Thalamus, Compression | 4 |
Thalamus, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Peripheral Nerve | M + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | 4 |
Lumen, Inflammation, Suppurative | 2 |
Mucosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|
| 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
300MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Iris, Synechia | |
Lens, Cataract | 4 |
Posterior Chamber, Hemorrhage | |
Retina, Dysplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 3 1 1 2 1 1 1 1 1 1 1 1 1 1 |
Cortex, Cyst | |
Pelvis, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A | 47 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A | 47 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 52 |
Clear Cell Focus | 1 | 6 1.7|
Congestion | | 1 2.0|
Developmental Malformation | X X | 6 |
Fatty Change | | 6 1.8|
Inflammation, Chronic | 1 1 2 | 20 1.6|
Mixed Cell Focus | | 1 |
Necrosis, Coagulative | | 4 1.8|
Bile Duct, Hyperplasia | 2 | 5 2.0|
Hepatocyte, Hyperplasia | | 2 2.0|
Periductular, Fibrosis | | 1 1.0|
Periductular, Infiltration Cellular, | | |
Lymphocyte | 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis, Coagulative | 3 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A | 49 |
Atrophy | 2 2 | 5 2.0|
Ectopic Tissue | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A | 48 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 51 |
Cardiomyopathy | 2 | 18 1.8|
Atrioventricular Valve, Fibrosis | | 1 3.0|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Angiectasis | | 1 3.0|
Hemorrhage | | 1 4.0|
Infarct | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia | 1 | 8 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 52 |
Pars Distalis, Cyst | X | 3 2.5|
Pars Distalis, Cyst Multilocular | | 2 2.0|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 1 2.0|
Pars Intermedia, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A | 50 |
C-Cell, Hyperplasia | 1 2 | 7 2.0|
Follicle, Cyst | | 1 2.0|
Follicle, Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 50 |
Hyperplasia | | 2 2.5|
Inflammation, Suppurative | | 5 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Dilatation | | 2 3.0|
Duct, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Follicle, Cyst | | 3 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 55 |
Hydrometra | | 6 3.2|
Hyperplasia, Cystic | | 6 2.7|
Cervix, Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 52 |
Hyperplasia, Lymphoid | | 1 3.0|
Lumbar, Pigmentation, Hemosiderin | | 1 2.0|
Mediastinal, Hyperplasia, Macrophage | | 1 2.0|
Prefemoral, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + A | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A | 49 |
Congestion | | 3 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 49 |
Galactocele | | 3 3.0|
Lactation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + A | 48 |
Hydrocephalus | | 1 3.0|
Hypothalamus, Compression | 3 3 | 3 3.0|
Thalamus, Compression | | 2 3.5|
Thalamus, Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 4| 5| 3| | |
DAY ON TEST | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8| | |
| 4| 2| 1| 0| 7| 0| 5| 1| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
300MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Alveolar Epithelium, Hyperplasia | 1 | 3 1.7|
Alveolus, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Lumen, Fungus | 3 | 2 3.5|
Lumen, Inflammation, Suppurative | | 1 2.0|
Mucosa, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Iris, Synechia | | 1 4.0|
Lens, Cataract | | 1 4.0|
Posterior Chamber, Hemorrhage | 4 | 1 4.0|
Retina, Dysplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A | 50 |
Nephropathy | 1 1 1 1 3 1 | 38 1.3|
Cortex, Cyst | 2 | 1 2.0|
Pelvis, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A | 48 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|
| 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 1 1 1 |
Congestion | 3 |
Developmental Malformation | X X |
Eosinophilic Focus | X |
Fatty Change | |
Inflammation, Chronic | 1 1 2 1 2 1|
Mixed Cell Focus | |
Necrosis, Coagulative | 2 2 |
Bile Duct, Hyperplasia | 1 2 2 2 |
Centrilobular, Necrosis, Coagulative | |
Hepatocyte, Cytoplasmic Alteration | |
Hepatocyte, Hyperplasia | 1 |
Periductular, Fibrosis | 2 2 |
Periductular, Inflammation, Chronic | 2 |
Periductular, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis, Coagulative | 3 |
Fat, Necrosis, Liquifactive | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
Inflammation, Chronic | |
Interstitium, Fibrosis | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Squamous | |
Inflammation, Chronic | |
Mineralization | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|
| 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 3 2 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 1 3 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Pars Distalis, Cyst | 3 2 2 |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 3 3|
Hyperplasia, Cystic | 2 4 |
Cervix, Inflammation, Suppurative | |
__________________________________________________________________________|
Vagina | + + |
Inflammation, Suppurative | 3 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|
| 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Histiocytic | |
Mediastinal, Congestion | 2 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 |
Developmental Malformation | |
Hyperplasia, Reticulum Cell | |
Pigmentation, Hemosiderin | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | X |
Tail, Hyperkeratosis | |
Tail, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
Cerebellum, Gliosis | |
Thalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|
| 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Foreign Body | |
Alveolus, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Lumen, Inflammation, Suppurative | 2 2 |
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 1 1 2 1 2 1 1 1 1|
Pelvis, Inflammation, Chronic | 2 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|
| 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + M + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + + +|
Clear Cell Focus | 2 1 2 |
Congestion | |
Developmental Malformation | X |
Eosinophilic Focus | |
Fatty Change | |
Inflammation, Chronic | 1 2 |
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 1 3 |
Centrilobular, Necrosis, Coagulative | 2 1 |
Hepatocyte, Cytoplasmic Alteration | |
Hepatocyte, Hyperplasia | |
Periductular, Fibrosis | |
Periductular, Inflammation, Chronic | 1 1 |
Periductular, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis, Coagulative | 3 |
Fat, Necrosis, Liquifactive | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | 1 4 |
Inflammation, Chronic | 2 |
Interstitium, Fibrosis | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + A + + + + +|
Fibrosis | 2 |
Hyperplasia, Squamous | 2 1 |
Inflammation, Chronic | 2 3 |
Mineralization | 2 2|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|
| 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + A + + + + +|
Cardiomyopathy | 2 2 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +|
Congestion | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M M + + + + + + M + + + + + M + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Congestion | |
Pars Distalis, Cyst | 3 2 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Suppurative | 4 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + A + + + + +|
Follicle, Cyst | 3 X |
__________________________________________________________________________|
Oviduct | + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 3|
Hyperplasia, Cystic | 4 |
Cervix, Inflammation, Suppurative | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|
| 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +|
Lumbar, Hyperplasia, Histiocytic | 3 |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + M|
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Congestion | |
Developmental Malformation | |
Hyperplasia, Reticulum Cell | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + A + + + + +|
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | |
Tail, Hyperkeratosis | 3 |
Tail, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hemorrhage | 3 |
Hydrocephalus | |
Cerebellum, Gliosis | |
Thalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + A + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|
| 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | 2 |
Alveolar Epithelium, Hyperplasia | 3|
Alveolus, Foreign Body | 3 1 |
Alveolus, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + A + + + + +|
Congestion | 4 |
Lumen, Inflammation, Suppurative | 2 2 |
Mucosa, Inflammation, Suppurative | 3 2|
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + A + + + + +|
Nephropathy | 4 1 1 2 2 1 3 1 1 2 1 2 1 1|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Clear Cell Focus | 2 | 8 1.5|
Congestion | | 1 3.0|
Developmental Malformation | X | 4 |
Eosinophilic Focus | | 1 |
Fatty Change | 2 | 1 2.0|
Inflammation, Chronic | 1 1 | 10 1.3|
Mixed Cell Focus | | 1 |
Necrosis, Coagulative | | 2 2.0|
Bile Duct, Hyperplasia | 3 | 7 2.0|
Centrilobular, Necrosis, Coagulative | | 2 1.5|
Hepatocyte, Cytoplasmic Alteration | 3 | 1 3.0|
Hepatocyte, Hyperplasia | 2 | 2 1.5|
Periductular, Fibrosis | | 2 2.0|
Periductular, Inflammation, Chronic | | 3 1.3|
Periductular, Inflammation, | | |
Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Inflammation, Chronic Active | 4 | 1 4.0|
Fat, Necrosis, Coagulative | 3 | 3 3.0|
Fat, Necrosis, Liquifactive | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | 2 | 5 2.0|
Inflammation, Chronic | | 1 2.0|
Interstitium, Fibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 2 1.5|
Inflammation, Chronic | | 2 2.5|
Mineralization | | 3 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Inflammation, Suppurative | | 1 2.0|
Ulcer | 3 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | | 10 2.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 1 | 8 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 53 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Pars Distalis, Cyst | 2 2 | 8 2.3|
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 2 1.5|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Inflammation, Suppurative | 2 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Follicle, Cyst | 3 | 4 3.0|
__________________________________________________________________________|____________|
Oviduct | + | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 3 3 | 8 3.0|
Hyperplasia, Cystic | | 3 3.3|
Cervix, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 3 |
Inflammation, Suppurative | | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Lumbar, Hyperplasia, Histiocytic | | 1 3.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Hyperplasia, Histiocytic| | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 3 | 3 3.0|
Hyperplasia, Plasma Cell | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Congestion | 4 | 4 3.3|
Developmental Malformation | X | 1 |
Hyperplasia, Reticulum Cell | | 1 2.0|
Pigmentation, Hemosiderin | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | I + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | | 1 |
Tail, Hyperkeratosis | | 1 3.0|
Tail, Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| | |
DAY ON TEST | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3| | |
| 0| 7| 4| 9| 8| 1| 4| 0| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Hemorrhage | | 1 3.0|
Hydrocephalus | 3 | 1 3.0|
Cerebellum, Gliosis | 1 | 1 1.0|
Thalamus, Compression | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Edema | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Alveolus, Foreign Body | | 2 2.0|
Alveolus, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Congestion | | 1 4.0|
Lumen, Inflammation, Suppurative | 1 | 5 1.8|
Mucosa, Inflammation, Suppurative | | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Nephropathy | 2 1 1 1 2 1 | 32 1.4|
Pelvis, Inflammation, Chronic | | 1 2.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Developmental Malformation | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|
| 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + A + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 1 |
Congestion | 2 |
Cytologic Alterations | 1 |
Developmental Malformation | X X X |
Fatty Change | 1 2 1 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 2 1 2 1 2 2 2 2 3 2 1 1 2|
Centrilobular, Necrosis, Coagulative | 1 |
Periductular, Fibrosis | 2 2 1 2|
Periductular, Inflammation, Chronic | 2 |
Periportal, Necrosis, Coagulative | |
Periportal, Pigmentation, Hemosiderin| 2 |
Portal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Inflammation, Chronic | |
Fat, Inflammation, Granulomatous | |
Fat, Inflammation, Suppurative | 2 |
Fat, Necrosis, Coagulative | 1 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 3 2 2 2 2 |
Inflammation, Chronic | 2 |
Acinar Cell, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Squamous | 1 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | |
Ulcer | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|
| 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 2 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst Multilocular | |
Pars Distalis, Hyperplasia | 1 |
Pars Intermedia, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Suppurative | 4 |
Lumen, Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 2|
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | M M + + + + + + + + + + + M M + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 4 1 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|
| 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 4 |
Lumen, Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Infiltration Cellular, Lymphocyte | |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 2 3 |
Developmental Malformation | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration, Secondary Wallerian | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 1|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|
| 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Edema | 2 |
Alveolus, Inflammation, Chronic | 1 |
Alveolus, Inflammation, Suppurative | |
Bronchiole, Inflammation, Suppurative| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Metaplasia, Squamous | |
Lumen, Foreign Body | 2 |
Lumen, Fungus | |
Lumen, Inflammation, Suppurative | 3 2 |
Mucosa, Inflammation, Suppurative | 2 |
Mucosa, Septum, Inflammation, Chronic| 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Hemorrhage, Chronic| 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
Nephropathy | 2 2 2 2 3 2 1 1 3 2 1 1 2 2 2 1 1 2 1 4 2 2 2 3|
Cortex, Cyst | 2 |
Pelvis, Inflammation, Suppurative | 4 |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
__________________________________________________________________________|
Ureter | + |
Mucosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | |
Submucosa, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|
DAY ON TEST | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|
| 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + A + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + A + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + A + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + A + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + A + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 1 1 |
Congestion | |
Cytologic Alterations | |
Developmental Malformation | X X X |
Fatty Change | 1 2 2 2 |
Inflammation, Chronic | 1 2 1 1 |
Inflammation, Suppurative | |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2|
Centrilobular, Necrosis, Coagulative | |
Periductular, Fibrosis | 2 1 1|
Periductular, Inflammation, Chronic | 2 |
Periportal, Necrosis, Coagulative | 1 |
Periportal, Pigmentation, Hemosiderin| |
Portal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fat, Inflammation, Chronic | 3 |
Fat, Inflammation, Granulomatous | 2 |
Fat, Inflammation, Suppurative | |
Fat, Necrosis, Coagulative | 3 3 4 2 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | 2 2 2 2 |
Inflammation, Chronic | |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + A + + + + + + + + + + + A + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperplasia, Squamous | 3 2 |
Inflammation, Chronic | 3 1 |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + A + A + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|
DAY ON TEST | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|
| 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 2 2 2 1 2 2 2 2 2 3 2 2 3 3 3 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Basophilic Focus | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst | 3 |
Hyperplasia | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst Multilocular | 2 |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Suppurative | |
Lumen, Dilatation | |
__________________________________________________________________________|
Epididymis | + + M + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 2 4 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + M + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|
DAY ON TEST | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|
| 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 |
Lumen, Dilatation | |
__________________________________________________________________________|
Testes | + + M + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + A + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | 2 2 |
Congestion | 3 2 |
Developmental Malformation | X |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + A + + A + + + + + + + + A + + + + + + + +|
Thalamus, Compression | 3 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration, Secondary Wallerian | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 2|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|
DAY ON TEST | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|
| 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Edema | |
Alveolus, Inflammation, Chronic | 1 |
Alveolus, Inflammation, Suppurative | 2 3 |
Bronchiole, Inflammation, Suppurative| 1 |
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +|
Fungus | |
Metaplasia, Squamous | 2 |
Lumen, Foreign Body | |
Lumen, Fungus | 3 4 3 |
Lumen, Inflammation, Suppurative | 3 2 4 2 2 2 |
Mucosa, Inflammation, Suppurative | |
Mucosa, Septum, Inflammation, Chronic| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Anterior Chamber, Hemorrhage, Chronic| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 3 3 2 2 3 3 1 4 2 2 2 2 1 2 3 1 2 2 1 1 1 2 3 2|
Cortex, Cyst | 3 3 |
Pelvis, Inflammation, Suppurative | 3 |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia, Oncocytic | |
__________________________________________________________________________|
Ureter | |
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + M + + + + + + + +|
Mucosa, Inflammation, Suppurative | 1 |
Submucosa, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + A + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + A + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + A + + A + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + M + + A + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Basophilic Focus | 2 2 | 2 2.0|
Clear Cell Focus | | 3 1.0|
Congestion | | 1 2.0|
Cytologic Alterations | | 1 1.0|
Developmental Malformation | | 6 |
Fatty Change | 2 2 | 9 1.7|
Inflammation, Chronic | 2 | 6 1.3|
Inflammation, Suppurative | | 1 2.0|
Mixed Cell Focus | | 1 |
Bile Duct, Hyperplasia | 2 2 2 | 29 1.9|
Centrilobular, Necrosis, Coagulative | 3 | 2 2.0|
Periductular, Fibrosis | | 7 1.6|
Periductular, Inflammation, Chronic | 2 2 | 4 2.0|
Periportal, Necrosis, Coagulative | | 1 1.0|
Periportal, Pigmentation, Hemosiderin| | 1 2.0|
Portal, Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 19 |
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Inflammation, Granulomatous | | 1 2.0|
Fat, Inflammation, Suppurative | | 1 2.0|
Fat, Necrosis, Coagulative | 3 4 3 2 | 13 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | | 9 2.1|
Inflammation, Chronic | | 1 2.0|
Acinar Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + | 56 |
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 3 2.0|
Inflammation, Chronic | | 3 1.7|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + | 55 |
Erosion | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + M + | 59 |
Cardiomyopathy | 3 2 2 2 2 2 2 2 | 45 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Basophilic Focus | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Cyst | | 1 3.0|
Hyperplasia | 2 | 3 1.7|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + A + + + + + + | 58 |
Pars Distalis, Cyst | | 2 2.0|
Pars Distalis, Cyst Multilocular | | 1 2.0|
Pars Distalis, Hyperplasia | | 2 1.5|
Pars Intermedia, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 2 1.5|
Follicle, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Inflammation, Suppurative | | 1 4.0|
Lumen, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + M + + + + | 56 |
Hyperplasia | | 3 2.3|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 2 | 4 2.5|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 54 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | | 9 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
Inflammation, Suppurative | | 3 3.7|
Lumen, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Atrophy | 4 3 2 | 4 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Interstitial Cell, Hyperplasia | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M | 59 |
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Atrophy | | 2 2.0|
Congestion | | 4 2.5|
Developmental Malformation | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 55 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 57 |
Thalamus, Compression | | 2 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
Degeneration, Secondary Wallerian | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + M + | 59 |
Alveolar Epithelium, Hyperplasia | | 4 1.5|
Alveolus, Edema | | 1 2.0|
Alveolus, Inflammation, Chronic | | 2 1.0|
Alveolus, Inflammation, Suppurative | | 2 2.5|
Bronchiole, Inflammation, Suppurative| | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | | 1 3.0|
Metaplasia, Squamous | | 1 2.0|
Lumen, Foreign Body | | 1 2.0|
Lumen, Fungus | | 3 3.3|
Lumen, Inflammation, Suppurative | | 8 2.5|
Mucosa, Inflammation, Suppurative | | 1 2.0|
Mucosa, Septum, Inflammation, Chronic| | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Anterior Chamber, Hemorrhage, Chronic| | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Nephropathy | 1 3 3 1 2 2 3 1 2 1 | 59 2.0|
Cortex, Cyst | | 3 2.7|
Pelvis, Inflammation, Suppurative | | 2 3.5|
Renal Tubule, Hyperplasia, Cystic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 6| 7| 4| 7| 4| | |
DAY ON TEST | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5| | |
| 8| 7| 0| 8| 0| 8| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia, Oncocytic | | 1 1.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Mucosa, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Mucosa, Inflammation, Suppurative | | 1 1.0|
Submucosa, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + A + + + + + + + + +|
Circumanal Gland, Hyperplasia, | |
Glandular | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Developmental Malformation | X X |
Fatty Change | 1 1 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 2 2 2 1 2 2 2 1 3 1 |
Centrilobular, Necrosis, Coagulative | 2 |
Hepatocyte, Hyperplasia | |
Periductular, Fibrosis | 2 2 2 1 |
Periductular, Infiltration Cellular, | |
Lymphocyte | |
Periductular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fat, Inflammation, Chronic | 3 |
Fat, Inflammation, Fibrinopurulent | 4 |
Fat, Necrosis, Coagulative | 2 3 2 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Ectopic Tissue | X |
Hyperplasia | |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Squamous | 3 3 2 1 3 1 |
Inflammation, Chronic | 2 4 3 1 |
Ulcer | 4 2 4 3 3 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Hemorrhage | 1 |
Inflammation, Chronic | 1 3 |
Mineralization | |
Ulcer | 3|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 1 2 2 2 3 2 2 2 2 1 3 1 3|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Hemorrhage | 3 |
Vacuolization Cytoplasmic | 3 3 3 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + + M + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Cyst Multilocular | 2 |
Pars Distalis, Hemorrhage, Chronic | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | M |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 4 3 3|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 3 |
Duct, Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 3 2 3 4 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Polyarteritis | 3 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | X |
Fibrosis | |
Hyperplasia, Lymphoid | 2 3 |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | |
Pigmentation, Hemosiderin | |
Perivascular, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + M + + + + + + + + + + + + + + + +|
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|
DAY ON TEST | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|
| 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + A + + + + + + + + +|
Hemorrhage | 3 |
Meninges, Congestion | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 3 |
Alveolus, Edema | 3 |
Alveolus, Hemorrhage | |
Alveolus, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | 3 |
Lumen, Inflammation, Suppurative | 2 2 2 2 3 |
Mucosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Perforation | |
__________________________________________________________________________|
Eye | |
Bilateral, Lens, Cataract | |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 4 2 2 2 4 2 1 4 2 3 4 3 3 2 3 3 1 3 2 2 3 3 4|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 2 |
Serosa, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A A + + + + + A + + + |
Circumanal Gland, Hyperplasia, | |
Glandular | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A A + + + + + A + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A A + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A A + + + + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + A + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus | |
Developmental Malformation | X X |
Fatty Change | 2 1 2 2 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | |
Necrosis, Coagulative | 1 1 1 2 |
Bile Duct, Hyperplasia | 2 2 1 3 4 |
Centrilobular, Necrosis, Coagulative | |
Hepatocyte, Hyperplasia | 2 |
Periductular, Fibrosis | 2 |
Periductular, Infiltration Cellular, | |
Lymphocyte | 2 |
Periductular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Inflammation, Chronic | |
Fat, Inflammation, Fibrinopurulent | 3 |
Fat, Necrosis, Coagulative | 3 3 3 2 4 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + A A + + + + + + + + + |
Atrophy | 2 2 |
Ectopic Tissue | |
Hyperplasia | 3 3 2 |
Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + |
Cyst Epithelial Inclusion | 3 |
Hyperplasia, Squamous | 2 1 3 2 3 |
Inflammation, Chronic | 4 2 4 1 |
Ulcer | 2 4 4 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Hemorrhage | |
Inflammation, Chronic | |
Mineralization | 1 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration | 2 |
Hemorrhage | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Cyst | 4 |
Hyperplasia | 2 |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A A + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M |
Hyperplasia | 2 1 3 3 2 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + |
Inflammation, Suppurative | |
Pars Distalis, Cyst | 3 |
Pars Distalis, Cyst Multilocular | |
Pars Distalis, Hemorrhage, Chronic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
Polyarteritis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + |
Hyperplasia | 4 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 4 4 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 3 |
Duct, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + A + + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Polyarteritis | |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + |
Hyperplasia, Lymphoid | 3 3 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Congestion | 2 3 |
Developmental Malformation | X |
Fibrosis | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | 3 |
Pigmentation, Hemosiderin | 2 |
Perivascular, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + |
Congestion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + A + + + |
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Alopecia | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|
DAY ON TEST | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|
| 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Metaplasia, Osseous | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Meninges, Congestion | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Edema | 3 |
Alveolus, Hemorrhage | 3 |
Alveolus, Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Lumen, Fungus | 3 4 3 |
Lumen, Inflammation, Suppurative | 2 2 |
Mucosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Perforation | |
__________________________________________________________________________|
Eye | |
Bilateral, Lens, Cataract | |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Nephropathy | 4 4 2 1 4 3 2 1 2 2 2 2 2 4 4 4 4 4 3 4 4 1 4 2|
Renal Tubule, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + |
Mucosa, Inflammation, Suppurative | |
Serosa, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + | 44 |
Circumanal Gland, Hyperplasia, | | |
Glandular | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + A + + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + A + + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + | 42 |
__________________________________________________________________________|____________|
Liver | A + + + + + + + | 49 |
Angiectasis | 1 1 | 3 1.0|
Basophilic Focus | 1 | 1 1.0|
Developmental Malformation | X | 5 |
Fatty Change | | 7 1.6|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis, Coagulative | | 4 1.3|
Bile Duct, Hyperplasia | 2 3 | 17 2.1|
Centrilobular, Necrosis, Coagulative | | 1 2.0|
Hepatocyte, Hyperplasia | | 1 2.0|
Periductular, Fibrosis | 3 | 6 2.0|
Periductular, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Periductular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 16 |
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Inflammation, Fibrinopurulent | 4 | 3 3.7|
Fat, Necrosis, Coagulative | | 11 2.7|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + | 47 |
Atrophy | | 4 2.3|
Ectopic Tissue | | 1 |
Hyperplasia | 2 3 | 5 2.6|
Inflammation, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | A + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst Epithelial Inclusion | | 1 3.0|
Hyperplasia, Squamous | | 11 2.2|
Inflammation, Chronic | | 8 2.6|
Ulcer | 4 4 3 | 14 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + | 47 |
Erosion | 2 4 | 3 2.3|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 2 2.0|
Mineralization | | 1 1.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 2 2 | 33 2.0|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | A + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | A + + + + + + + | 49 |
Cytoplasmic Alteration | | 1 2.0|
Hemorrhage | | 1 3.0|
Vacuolization Cytoplasmic | 2 | 6 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | A + + + + + + + | 49 |
Cyst | | 1 4.0|
Hyperplasia | | 2 2.0|
Necrosis, Liquifactive | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | A M M + I + + + | 41 |
Hyperplasia | | 15 2.1|
__________________________________________________________________________|____________|
Pituitary Gland | A + + + + + + + | 48 |
Inflammation, Suppurative | | 1 4.0|
Pars Distalis, Cyst | 3 | 4 3.0|
Pars Distalis, Cyst Multilocular | | 1 2.0|
Pars Distalis, Hemorrhage, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + | 48 |
C-Cell, Hyperplasia | 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 49 |
Hyperplasia | | 2 3.5|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 3 2 | 9 3.4|
Duct, Dilatation | | 2 3.0|
Duct, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | A + + + + + + + | 48 |
Inflammation, Suppurative | | 8 3.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | A + + + + + + + | 52 |
Atrophy | | 3 4.0|
Polyarteritis | | 1 3.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + | 49 |
Hypercellularity | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | A + + + + + + + | 49 |
Renal, Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | A + + + + + + + | 48 |
Hyperplasia, Lymphoid | | 4 3.0|
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + + | 49 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + | 48 |
Congestion | | 3 2.7|
Developmental Malformation | | 2 |
Fibrosis | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.3|
Infiltration Cellular, Mononuclear | | |
Cell | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Perivascular, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 47 |
Congestion | | 1 3.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 46 |
Galactocele | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Alopecia | | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Metaplasia, Osseous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 49 |
Hemorrhage | | 1 3.0|
Meninges, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Alveolus, Edema | | 2 3.0|
Alveolus, Hemorrhage | 2 | 2 2.5|
Alveolus, Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Lumen, Fungus | 3 | 5 3.2|
Lumen, Inflammation, Suppurative | 3 | 8 2.3|
Mucosa, Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 6| 4| 4| 6| 7| 4| | |
DAY ON TEST | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6| | |
| 8| 7| 9| 4| 1| 8| 8| 3| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Perforation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + | 2 |
Bilateral, Lens, Cataract | 3 | 1 3.0|
Lens, Cataract | 4 | 1 4.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + | 58 |
Nephropathy | 4 3 2 4 2 2 1 4 2 | 57 2.8|
Renal Tubule, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + | 48 |
Mucosa, Inflammation, Suppurative | | 1 2.0|
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | A + + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + + A + + + + + + + + + + + + + + |
Submucosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + A + + + + + + + + + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + M + + + + + + + + + |
Angiectasis | |
Clear Cell Focus | 2 |
Developmental Malformation | X X |
Inflammation, Necrotizing | 4 |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 2 1 3 3 2 |
Centrilobular, Necrosis, Coagulative | 4 1 3 3 2 |
Hepatocyte, Hyperplasia | 2 |
Periductular, Fibrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + M +|
Fat, Inflammation, Chronic | 3 |
Fat, Inflammation, Chronic Active | 4 4 |
Fat, Necrosis, Coagulative | 2 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + |
Atrophy | |
Hemorrhage | |
Hyperplasia | 2 3 |
Inflammation, Chronic | 4 |
Polyarteritis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + M + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Hyperkeratosis | |
Hyperplasia, Squamous | 3 2 3 3 1 1 1 1 |
Inflammation, Chronic | 1 2 4 2 1 1 1 1 |
Ulcer | 3 4 2 4 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Erosion | 2 |
Inflammation, Chronic | 1 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Necrosis, Zenkers | 2 |
Atrioventricular Valve, Thrombosis | 3 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 2 2 2 2 3 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + A + + + + + + + + + + + M + + + |
Pars Distalis, Cyst | 3 2 2 4 |
Pars Distalis, Cyst Multilocular | X |
Pars Distalis, Hemorrhage, Acute | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | A + + + + + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 3 3 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 4 4 2 |
Duct, Dilatation | |
Duct, Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | A + + + + + + + + + + + M + + + + + M + + + |
Hyperplasia | 1 |
Inflammation, Suppurative | 2 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + + + + + + + M + + + + + M + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | 4 4|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Neutrophil | 3 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Lumbar, Congestion | 3 |
Mediastinal, Congestion | 2 |
Mediastinal, Inflammation, | |
Suppurative | 4 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + M M + + |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Spleen | + + + M + + + A + + + + + + + + + + M + + + |
Congestion, Diffuse | |
Congestion | 3 3 |
Developmental Malformation | X |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + |
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + + + |
Alopecia | 3 3 |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 2 |
Inflammation, Suppurative | |
Subcutaneous Tissue, Developmental | |
Malformation | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|
DAY ON TEST | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|
| 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + M + + + |
Hypothalamus, Hemorrhage, Acute | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + + + |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Hemorrhage | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M + + + |
Autolysis | |
Fungus | 4 |
Inflammation, Chronic | |
Lumen, Fungus | 3 3 3 |
Lumen, Inflammation, Suppurative | 3 2 3 2 |
Mucosa, Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Acanthosis | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + M + + + + + + + + + + + + + + + + M + + + +|
Nephropathy | 4 3 4 4 4 4 4 4 4 4 3 4 4 2 4 2 4 1 2 4 2 3 1|
Cortex, Infarct | 3 |
Renal Tubule, Hyperplasia, Cystic | 1 2 |
Renal Tubule, Hyperplasia, Oncocytic | 2 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + A + + + + M + + + + + M + + + |
Submucosa, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + + + + + + + + + A + + + A + +|
Submucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + A + + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + + + + + + + + + A + + + A + +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Developmental Malformation | |
Inflammation, Necrotizing | |
Necrosis, Coagulative | 1 |
Bile Duct, Hyperplasia | 2 2 3 2 2 2 2 |
Centrilobular, Necrosis, Coagulative | 2 3 1 |
Hepatocyte, Hyperplasia | 1 1 |
Periductular, Fibrosis | 3 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis, Coagulative | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hemorrhage | |
Hyperplasia | 3 |
Inflammation, Chronic | |
Polyarteritis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperkeratosis | 4 |
Hyperplasia, Squamous | 3 1 1 1 1 |
Inflammation, Chronic | 3 3 1 1 1 1 3 |
Ulcer | 3 4 1 4 3 2 3 2 3 3 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 3 2 |
Necrosis, Zenkers | |
Atrioventricular Valve, Thrombosis | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M|
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 2 2 2 2 3 2 3 3 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Cyst Multilocular | |
Pars Distalis, Hemorrhage, Acute | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 3 4|
Duct, Dilatation | 3 |
Duct, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia | |
Inflammation, Suppurative | 4 2 3 4 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Interstitial Cell, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Congestion | |
Mediastinal, Congestion | |
Mediastinal, Inflammation, | |
Suppurative | |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Pancreatic, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + M|
Hyperplasia, Plasma Cell | 3 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + M|
Congestion, Diffuse | 4 |
Congestion | |
Developmental Malformation | |
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 3 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M|
Alopecia | |
Cyst Epithelial Inclusion | 3 |
Hyperkeratosis | |
Inflammation, Suppurative | |
Subcutaneous Tissue, Developmental | |
Malformation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|
DAY ON TEST | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|
| 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + + + M|
Hypothalamus, Hemorrhage, Acute | |
__________________________________________________________________________|
Peripheral Nerve | + M + + |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Hemorrhage | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M|
Autolysis | 4 |
Fungus | X |
Inflammation, Chronic | 2 |
Lumen, Fungus | 4 4 |
Lumen, Inflammation, Suppurative | 4 2 |
Mucosa, Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Acanthosis | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + M|
Nephropathy | 3 3 1 4 3 3 3 4 3 1 4 1 4 3 3 2 4 2 2 4 3 2 1 4 |
Cortex, Infarct | |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia, Oncocytic | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + M|
Submucosa, Infiltration Cellular, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + A + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + A + | 41 |
Submucosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + A + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + A + | 44 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + A + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + A + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + A + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + A + | 43 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 53 |
Angiectasis | 1 | 1 1.0|
Clear Cell Focus | | 1 2.0|
Developmental Malformation | | 2 |
Inflammation, Necrotizing | | 1 4.0|
Necrosis, Coagulative | | 1 1.0|
Bile Duct, Hyperplasia | 2 | 13 2.2|
Centrilobular, Necrosis, Coagulative | | 8 2.4|
Hepatocyte, Hyperplasia | | 3 1.3|
Periductular, Fibrosis | 2 | 9 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 11 |
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Inflammation, Chronic Active | | 2 4.0|
Fat, Necrosis, Coagulative | 4 | 6 2.7|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + | 48 |
Atrophy | | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 3 | 4 2.8|
Inflammation, Chronic | | 1 4.0|
Polyarteritis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Hemorrhage | 4 | 1 4.0|
Hyperkeratosis | | 1 4.0|
Hyperplasia, Squamous | 1 | 14 1.6|
Inflammation, Chronic | | 15 1.7|
Ulcer | 2 4 | 20 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 50 |
Erosion | 2 | 4 2.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 2 | 34 2.0|
Necrosis, Zenkers | | 1 2.0|
Atrioventricular Valve, Thrombosis | | 1 3.0|
Atrium, Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 49 |
Vacuolization Cytoplasmic | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 49 |
Hyperplasia | | 5 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + | 48 |
Hyperplasia | | 26 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 48 |
Pars Distalis, Cyst | 3 | 7 2.6|
Pars Distalis, Cyst Multilocular | | 1 |
Pars Distalis, Hemorrhage, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 49 |
C-Cell, Hyperplasia | | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 48 |
Hyperplasia | | 6 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 7 3.1|
Duct, Dilatation | 4 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 46 |
Hyperplasia | | 1 1.0|
Inflammation, Suppurative | 2 | 12 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 46 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 51 |
Atrophy | 4 | 4 3.5|
Interstitial Cell, Hyperplasia | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
Hyperplasia, Neutrophil | | 1 3.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 50 |
Lumbar, Congestion | | 1 3.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Inflammation, | | |
Suppurative | | 1 4.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 2.0|
Pancreatic, Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 44 |
Hyperplasia, Plasma Cell | | 2 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 50 |
Congestion | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 45 |
Congestion, Diffuse | | 1 4.0|
Congestion | | 2 3.0|
Developmental Malformation | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Macrophage | | 2 2.5|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 47 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M | 47 |
Galactocele | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 48 |
Alopecia | | 2 3.0|
Cyst Epithelial Inclusion | | 1 3.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Subcutaneous Tissue, Developmental | | |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 46 |
Hypothalamus, Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 7 |
__________________________________________________________________________|____________|
Spinal Cord | | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Alveolus, Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 48 |
Autolysis | | 1 4.0|
Fungus | | 2 4.0|
Inflammation, Chronic | | 1 2.0|
Lumen, Fungus | 3 | 6 3.3|
Lumen, Inflammation, Suppurative | 2 2 3 | 9 2.6|
Mucosa, Inflammation, Suppurative | | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Acanthosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 4| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5| | |
| 7| 0| 9| 1| 9| 3| 9| 8| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
300MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 57 |
Nephropathy | 2 3 2 3 1 4 3 3 2 1 | 57 2.9|
Cortex, Infarct | | 1 3.0|
Renal Tubule, Hyperplasia, Cystic | | 2 1.5|
Renal Tubule, Hyperplasia, Oncocytic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 44 |
Submucosa, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|
DAY ON TEST | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|
| 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + A + + + + A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A A A A + + + + + + + + + + + A + A A A + A|
Inflammation, Suppurative | |
Submucosa, Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + A + A + + A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small | + A + + + A A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + A A A A + + + + + + + + A + + A + A + A A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A A A + + + + + + + + + + + A + A + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 2 |
Developmental Malformation | X |
Inflammation, Chronic | |
Necrosis, Coagulative | 2 |
Regeneration | 3 |
Artery, Dilatation | |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 2 2 3 2 2 |
Centrilobular, Inflammation, | |
Necrotizing | |
Centrilobular, Necrosis, Coagulative | 3 2 2 |
Hepatocyte, Hyperplasia | |
Periductular, Fibrosis | 1 2 |
Periductular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Coagulative | 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + A + A|
Atrophy | 4 |
Hyperplasia | 3 |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 2 |
Necrosis, Liquifactive | |
Interstitium, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + M + M M M|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 1 2 2 3 1 1 |
Inflammation, Chronic | 1 1 1 1 |
Ulcer | 2 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + A + A|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|
DAY ON TEST | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|
| 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Inflammation, Chronic | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 3 2 2 2 3 2 2 1 2 2 3 2 2|
Atrioventricular Valve, Fibrosis | |
Atrium, Inflammation, Suppurative | |
Atrium, Thrombosis | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + M + M + + M M M|
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + A + +|
Pars Distalis, Cyst | X |
Pars Distalis, Cyst Multilocular | |
__________________________________________________________________________|
Thyroid Gland | + A + + + + M + + + + + + + + + + + + + + + M M M|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | X 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 4 3|
Duct, Dilatation | 2 |
Duct, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | 2 4 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|
DAY ON TEST | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|
| 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitium, Hemorrhage, Acute | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy | 4 |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + A + +|
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + M + M M M|
Congestion | |
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + A + A|
Fibrosis | 2 |
Necrosis, Liquifactive | 4 |
Pigmentation, Hemosiderin | 2 |
Subcapsular, Hemorrhage | |
__________________________________________________________________________|
Thymus | + A + + + + + + + + + + + + + + + + + + + + M + +|
Hemorrhage | 3 |
Capsule, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + A|
Alopecia | 2 |
Cyst Epithelial Inclusion | 4 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + A + A|
Thalamus, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|
DAY ON TEST | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|
| 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Congestion | |
Alveolus, Edema | 2 |
Alveolus, Foreign Body | 1 |
Alveolus, Hemorrhage | 3 |
Alveolus, Inflammation, Suppurative | 3 |
Bronchiole, Inflammation, Suppurative| |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
Fungus | |
Lumen, Foreign Body | 2 2 |
Lumen, Fungus | |
Lumen, Inflammation, Suppurative | 3 3|
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A M +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Inflammation, Suppurative | |
Nephropathy | 4 3 3 2 3 4 3 2 3 2 4 2 1 3 2 1 4 3 4 4 3 3|
Cortex, Cyst | |
Cortex, Infarct | 3 |
Pelvis, Inflammation, Chronic | |
Pelvis, Inflammation, Suppurative | 2 |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + A + A|
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|
| 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A A + + + + + + + + + + + + A + + A A A + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + + + + A + A A A + A A A + + A A +|
Inflammation, Suppurative | |
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Colon | A A + + + + + + + + + + + + A + + A A A + + A A +|
__________________________________________________________________________|
Intestine Large, Rectum | A A + + + + + + + + + + + + A + + A A A + + A + +|
__________________________________________________________________________|
Intestine Small | A A + + + + + + + + + + + + A + + A A A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + + + + A + + A A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + A + A A A + A A A + + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + + + + + A + + A A A + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 2 |
Developmental Malformation | X X X |
Inflammation, Chronic | |
Necrosis, Coagulative | 2 3 3 |
Regeneration | |
Artery, Dilatation | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 2 2 1 |
Centrilobular, Inflammation, | |
Necrotizing | 2 |
Centrilobular, Necrosis, Coagulative | 3 |
Hepatocyte, Hyperplasia | 1 |
Periductular, Fibrosis | 1 |
Periductular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis, Coagulative | 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + A A + + + A A + + + + +|
Atrophy | |
Hyperplasia | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Necrosis, Liquifactive | |
Interstitium, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + A + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 1 |
Inflammation, Chronic | 2 1 |
Ulcer | 2 3 3 2 1 3 3 2 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|
| 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 2 |
Inflammation, Chronic | |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 3 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2|
Atrioventricular Valve, Fibrosis | 3 |
Atrium, Inflammation, Suppurative | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Pituitary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Cyst Multilocular | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M A + + + + + + + + + +|
C-Cell, Hyperplasia | 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 3 4 4|
Duct, Dilatation | 4 |
Duct, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|
| 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitium, Hemorrhage, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + M + + + + + + +|
Atrophy | 4|
Interstitial Cell, Hyperplasia | 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Fibrosis | |
Necrosis, Liquifactive | 2 |
Pigmentation, Hemosiderin | |
Subcapsular, Hemorrhage | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + M|
Hemorrhage | |
Capsule, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Necrosis | 3|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|
| 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Congestion | 3 |
Alveolus, Edema | |
Alveolus, Foreign Body | |
Alveolus, Hemorrhage | |
Alveolus, Inflammation, Suppurative | 1 |
Bronchiole, Inflammation, Suppurative| 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Lumen, Foreign Body | |
Lumen, Fungus | 4 4 4 |
Lumen, Inflammation, Suppurative | 3 2 3 |
Mucosa, Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Suppurative | 3 |
Nephropathy | 3 4 4 2 2 1 4 2 4 1 4 4 4 4 1 4 4 4 4 4 4 4 4 4 3|
Cortex, Cyst | 4 |
Cortex, Infarct | |
Pelvis, Inflammation, Chronic | 3 |
Pelvis, Inflammation, Suppurative | |
Renal Tubule, Hyperplasia, Cystic | 2 |
Renal Tubule, Hyperplasia | 2 1 |
__________________________________________________________________________|
Urinary Bladder | A A + + + + + + + + + + + + + + + + A A + + A + +|
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + A + + A + A A + A | 42 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + A + A A + A | 34 |
Inflammation, Suppurative | 4 | 1 4.0|
Submucosa, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + A + A A + A | 40 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + A + A A + A | 42 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + A A + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + A A + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + A + A A + A | 33 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + A A + A | 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 4 1.8|
Developmental Malformation | X | 5 |
Inflammation, Chronic | 2 | 1 2.0|
Necrosis, Coagulative | | 4 2.5|
Regeneration | | 1 3.0|
Artery, Dilatation | 4 | 1 4.0|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 2 | 10 2.0|
Centrilobular, Inflammation, | | |
Necrotizing | | 1 2.0|
Centrilobular, Necrosis, Coagulative | 3 | 5 2.6|
Hepatocyte, Hyperplasia | | 1 1.0|
Periductular, Fibrosis | 2 | 4 1.5|
Periductular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Necrosis, Coagulative | | 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + A + + + + A A + A | 48 |
Atrophy | | 1 4.0|
Hyperplasia | 2 2 | 4 2.5|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Necrosis, Liquifactive | 3 | 1 3.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M M + + | 52 |
__________________________________________________________________________|____________|
Stomach | + A + + + + A + + + | 56 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + A + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | 3 4 2 | 11 2.0|
Inflammation, Chronic | 2 1 | 8 1.3|
Ulcer | 3 | 16 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + A + + + | 53 |
Erosion | 2 | 4 1.8|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 3 2 2 2 2 | 40 2.1|
Atrioventricular Valve, Fibrosis | | 1 3.0|
Atrium, Inflammation, Suppurative | | 1 3.0|
Atrium, Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Cytoplasmic Alteration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A A + A | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 51 |
Hyperplasia | 2 2 | 19 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + | 56 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Cyst Multilocular | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + M M + + | 50 |
C-Cell, Hyperplasia | 3 | 3 2.7|
Follicle, Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + M + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + | 59 |
Hyperplasia | 4 | 2 3.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | 4 | 7 3.7|
Duct, Dilatation | | 2 3.0|
Duct, Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Inflammation, Suppurative | 4 4 | 5 3.2|
Interstitium, Hemorrhage, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + M + + + + + + + M | 56 |
Atrophy | 4 | 3 4.0|
Interstitial Cell, Hyperplasia | | 4 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + | 58 |
Mediastinal, Congestion | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M M + + | 52 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 2 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + | 57 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 55 |
Fibrosis | | 1 2.0|
Necrosis, Liquifactive | | 2 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Subcapsular, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + | 55 |
Hemorrhage | | 1 3.0|
Capsule, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M + + + + | 53 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Alopecia | | 1 2.0|
Cyst Epithelial Inclusion | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + + + | 57 |
Thalamus, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
__________________________________________________________________________|____________|
Spinal Cord | | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia | 2 | 3 1.7|
Alveolus, Congestion | | 1 3.0|
Alveolus, Edema | | 1 2.0|
Alveolus, Foreign Body | | 1 1.0|
Alveolus, Hemorrhage | | 1 3.0|
Alveolus, Inflammation, Suppurative | | 2 2.0|
Bronchiole, Inflammation, Suppurative| | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | | 1 2.0|
Lumen, Foreign Body | | 2 2.0|
Lumen, Fungus | 4 | 4 4.0|
Lumen, Inflammation, Suppurative | 4 2 3 | 8 2.9|
Mucosa, Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9| | |
| 8| 3| 9| 2| 1| 0| 7| 6| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Fibrosis | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 3 2 1 4 4 4 3 4 4 3 | 57 3.1|
Cortex, Cyst | | 1 4.0|
Cortex, Infarct | | 1 3.0|
Pelvis, Inflammation, Chronic | | 1 3.0|
Pelvis, Inflammation, Suppurative | | 1 2.0|
Renal Tubule, Hyperplasia, Cystic | | 1 2.0|
Renal Tubule, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + A A + A | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| | |
| 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Intestine Large | A | |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | |
__________________________________________________________________________|____________|
Intestine Large, Colon | A | |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A | |
__________________________________________________________________________|____________|
Intestine Small | A | |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Necrosis, Coagulative | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Granuloma | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 1 2 1 2 1 1 2 2 2 1 1 1 2 1 2 1 2 | 17 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + M M + + + M + + + + | 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| | |
| 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Degeneration | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| | |
| 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 4 | 1 4.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 19 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Intestine Large | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 4 | 1 4.0|
Developmental Malformation | X | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
Kupffer Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 2 1 1 1 1 1 1 2 2 1 1 1 1 | 13 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + M + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic Active | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Seminiferous Tubule, Degeneration | 3 3 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + | 1 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 1 2.0|
Submucosa, Congestion | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
39 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 18 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5| | |
| 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
41 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + A A + + A + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A + A + A A + + A + + + + + + + A + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A A + A + A A + + A + + + + + + + A + | 13 |
Polyarteritis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + A A + + A + + + + + + + + + | 16 |
Polyarteritis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + A A + A + A A + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A + A + A A + + A + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + M + A A + A A + + + + + + + A + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + A + A M + A + + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Liver | + + + + + + A + + + + + + + + + + + + + | 19 |
Fatty Change | 4 2 | 2 3.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
Necrosis, Coagulative | 2 2 | 2 2.0|
Bile Duct, Hyperplasia | 2 2 | 2 2.0|
Hepatocyte, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 3 |
Polyarteritis | 4 | 1 4.0|
Fat, Necrosis, Coagulative | 3 3 4 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + | 19 |
Polyarteritis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + A + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + | 19 |
Hyperplasia, Squamous | 1 2 | 2 1.5|
Inflammation, Chronic | 1 3 | 2 2.0|
Ulcer | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + A + + + + + + + + + + + + + | 18 |
Mineralization | 3 | 1 3.0|
Polyarteritis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Parenchyma, Edema | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 3 |
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 2 2 2 2 2 3 2 2 | 8 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5| | |
| 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
41 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Necrosis, Zenkers | 3 | 1 3.0|
Polyarteritis | 4 | 1 4.0|
Atrioventricular Valve, Fibrosis | 3 | 1 3.0|
Atrium, Thrombosis | 4 | 1 4.0|
Valve, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Clear Cell Focus | 3 | 1 3.0|
Cytoplasmic Alteration | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + M + | 18 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + M | 18 |
Hyperplasia | 4 2 3 2 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + A + + + + + + + + M + + + + | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + A + + + + + + + + + + | 18 |
Polyarteritis | 3 | 1 3.0|
C-Cell, Hyperplasia | 3 | 1 3.0|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Abscess | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
Polyarteritis | 3 | 1 3.0|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Suppurative | 2 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + A A + A + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5| | |
| 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
41 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Polyarteritis | 4 | 1 4.0|
Renal, Hyperplasia, Macrophage | 3 | 1 3.0|
Renal, Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A M + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + + + + + + | 19 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + A + + + + + + + + + + + + + | 18 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + | 19 |
Lactation | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic Active | 4 | 1 4.0|
Polyarteritis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
Fibrous Osteodystrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Polyarteritis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + A + + + + + + + + + + + + + | 19 |
Hydrocephalus | 3 | 1 3.0|
Polyarteritis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Polyarteritis | 3 | 1 3.0|
Alveolus, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5| | |
| 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
600MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
41 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lumen, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 4 | 1 4.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy | 3 2 3 2 3 2 4 3 4 4 3 4 3 4 3 3 4 2 2 | 19 3.1|
Polyarteritis | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Clear Cell Focus | 2 | 1 2.0|
Fatty Change | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 1 2 2 | 4 1.8|
Periductular, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Fibrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 2 2 2 2 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + | 9 |
Pars Distalis, Hypertrophy | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Interstitial Cell, Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Chronic | 3 2 2 | 3 2.3|
Lumen, Fungus | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 1 1 1 1 1 2 2 2 | 10 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Bile Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Fibrosis | 2 | 1 2.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
Erosion | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Congestion | 3 | 1 3.0|
Pars Distalis, Cyst | 2 X | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Abscess | 4 | 1 4.0|
Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Interstitial Cell, Hyperplasia | 3 3 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 2 2 2 2 2 1 1 2 1 1 | 10 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
65 KILL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + A + + + + A A | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + A A | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 19 |
Diverticulum | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A | 19 |
Angiectasis | 1 | 1 1.0|
Developmental Malformation | X | 1 |
Ectasia | 2 | 1 2.0|
Fatty Change | 1 | 1 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M M + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Squamous | 2 | 1 2.0|
Inflammation, Chronic | 3 1 4 1 | 4 2.3|
Ulcer | 4 4 4 3 | 4 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
Erosion | 1 | 1 1.0|
Mineralization | 3 2 3 3 3 | 5 2.8|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 4 |
Aorta, Mineralization | 4 2 | 2 3.0|
Pulmonary Artery, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Cardiomyopathy | 1 3 1 2 2 3 2 3 1 | 9 2.0|
Necrosis, Zenkers | 4 | 1 4.0|
Artery, Mineralization | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia | 3 | 1 3.0|
Necrosis, Liquifactive | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
Hyperplasia | 2 3 2 4 3 3 3 3 2 | 9 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hemorrhage, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + M M + + + + + + + + + + | 18 |
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia | 4 4 | 2 4.0|
Inflammation, Suppurative | 2 3 4 | 3 3.0|
Duct, Inflammation, Chronic | 2 | 1 2.0|
Duct, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Suppurative | 3 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 20 |
Mediastinal, Hemorrhage, Acute | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + | 18 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 20 |
Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M M + + + + + M M + + + + + + M | 15 |
Galactocele | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
Cyst Epithelial Inclusion | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
Degeneration, Cystic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + M M + + + + + + + + + + | 18 |
Hypothalamus, Compression | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Congestion | 2 | 1 2.0|
Alveolus, Edema | 3 | 1 3.0|
Alveolus, Hemorrhage | 2 | 1 2.0|
Alveolus, Inflammation, Chronic | 2 | 1 2.0|
Bronchiole, Inflammation, Suppurative| 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + M M + + + + + + + + + + | 18 |
Lumen, Fungus | 3 | 1 3.0|
Lumen, Inflammation, Suppurative | 3 | 1 3.0|
Mucosa, Inflammation, Suppurative | 4 2 | 2 3.0|
Mucosa, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 120
NTP Experiment-Test: 05091-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,4-DIHYDROCOUMARIN Date: 04/25/97
Route: GAVAGE Time: 09:56:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 5| 6| 7| 7| 6| 6| 4| 5| 5| 6| 6| 5| 7| 3| 6| 7| | |
DAY ON TEST | 1| 5| 2| 2| 2| 6| 1| 1| 3| 3| 5| 2| 0| 9| 6| 2| 2| 8| 0| 2| | |
| 6| 5| 8| 9| 8| 1| 8| 8| 8| 4| 5| 9| 7| 7| 1| 9| 9| 5| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
600MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
65 STOP | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy | 4 4 4 2 4 4 4 4 4 4 2 4 4 4 4 3 4 3 2 3 | 20 3.6|
Cortex, Cyst | 1 3 3 | 3 2.3|
Renal Tubule, Hyperplasia | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
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