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TDMS Study 05091-01 Pathology Tables

NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97
Route: GAVAGE                                                                                                     Time: 09:56:58




       Facility:  American Biogenics Corp.

       Chemical CAS #:  119-84-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|             
                                           | 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Basophilic Focus                     |                                              2     2  2                  |             
      Clear Cell Focus                     |                   1           1                                          |             
      Developmental Malformation           | X           X                                                            |             
      Fatty Change                         |                                        2                                 |             
      Inflammation, Chronic                | 1              2  1  2     1  2     2  3                    1  2     2   |             
      Bile Duct, Hyperplasia               |       1                          1                                      2|             
      Central Vein, Dilatation             |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Periductular, Fibrosis               |                                                                          |             
      Periductular, Inflammation, Chronic  |                                                                          |             
      Sinusoid, Dilatation                 |                                                                      1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                          +                        |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis, Coagulative           |                      2                          3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |             2                                                            |             
      Infiltration Cellular, Lymphocyte    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periductular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                          2               |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|             
                                           | 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1           1                                2  3  1               |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        2                                 |             
      Pars Distalis, Cyst Multilocular     | 2                                                                        |             
      Pars Distalis, Hyperplasia           |                                                             2            |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1                                                  2   |             
      Follicle, Cyst                       |                      2     2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                      3                                                   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                      3   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   4      |             
      Hydrometra                           |          3                             2  3                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prefemoral, Hyperplasia, Lymphoid    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|             
                                           | 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Inflammation, Suppurative            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |             3                                                            |             
      Necrosis, Liquifactive               |          4                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Epithelial Cell, Cyst                |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                               X  X                             3         |             
      Lactation                            |                                                                          |             
      Acinus, Hyperplasia                  |                      3                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                          3               |             
      Hypothalamus, Compression            |                                                                          |             
      Meninges, Inflammation, Chronic      |                                  2                                       |             
      Thalamus, Compression                |                3                                                         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                               2                                          |             
      Alveolus, Edema                      |    3                                                                     |             
      Alveolus, Hemorrhage                 |          2                                                               |             
      Alveolus, Inflammation, Chronic      | 1     2     1              2        2  2           1           2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                      2  3                                                |             
      Lumen, Inflammation, Chronic         |                            2                                             |             
      Lumen, Inflammation, Suppurative     |                                                 3  2                     |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 6| 7| 5| 6| 4| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 6| 6| 6| 3| 9| 9| 6| 1| 8| 3| 4|             
                                           | 1| 3| 1| 0| 1| 0| 0| 1| 1| 1| 1| 0| 4| 1| 2| 1| 5| 4| 8| 6| 2| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Suppurative    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1     1     1  1     1     1  1  1                 1     1     1        1|             
      Collecting Tubule, Mineralization    |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Necrosis, Coagulative        |                                                 3                        |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|             
                                           | 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |          X                       X                 X        X           X|             
      Fatty Change                         |                   2                                                      |             
      Inflammation, Chronic                | 3        1        2     2  2  1  2                    2                 1|             
      Bile Duct, Hyperplasia               |                                                             2           2|             
      Central Vein, Dilatation             |                            1                                             |             
      Hepatocyte, Hyperplasia              |                                  2                                       |             
      Periductular, Fibrosis               |                                                             2            |             
      Periductular, Inflammation, Chronic  |                2                             2  3              1         |             
      Sinusoid, Dilatation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +  +  +                                   +                        |             
      Fat, Inflammation, Chronic           |          2                                                               |             
      Fat, Necrosis, Coagulative           | 2     2     3                                   3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               1                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periductular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |    2                                                                     |             
      Submandibular Gland, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                            3                                             |             
      Inflammation, Chronic                |             3                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    3           1                                                         |             
      Ulcer                                | 1                                                        3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|             
                                           | 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2           2                    2  2  1                             2|             
      Inflammation, Suppurative            |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                   2                                                      |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3                                    |             
      Hyperplasia                          |       1  1        1        1                                1     1      |             
      Infiltration Cellular, Lymphocyte    |                                                                         1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    3                             2                                       |             
      Pars Distalis, Cyst Multilocular     |          X                          2                             3      |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Nervosa, Cyst                   |          3                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     3           2        2           2   |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            4                                2            |             
      Inflammation, Suppurative            |                         3                                                |             
      Duct, Dilatation                     |          2                             3                    3            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                  4        3           3                  |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                      +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |       2                                               4                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prefemoral, Hyperplasia, Lymphoid    |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|             
                                           | 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |          2                                                               |             
      Depletion Lymphoid                   |       1                                                                  |             
      Fibrosis                             |                                                                          |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Epithelial Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Galactocele                          |                                                                          |             
      Lactation                            |                                                                      2   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Hypothalamus, Compression            |                      4                                                   |             
      Meninges, Inflammation, Chronic      |                                                                          |             
      Thalamus, Compression                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                     1                                    |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Inflammation, Chronic      |                            2              2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Chronic         |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 4| 6| 7| 5| 7| 4| 7| 5| 7|             
                             DAY ON TEST   | 8| 6| 3| 3| 3| 6| 3| 6| 3| 3| 1| 3| 3| 6| 3| 6| 6| 8| 3| 8| 3| 6| 3| 0| 3|             
                                           | 5| 1| 4| 1| 1| 1| 0| 6| 1| 0| 6| 4| 4| 1| 1| 1| 2| 0| 1| 0| 4| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |                   2  1     1     2  1  1     1     1     1               |             
      Collecting Tubule, Mineralization    |                1                                                         |             
      Cortex, Cyst                         |                                           3                              |             
      Cortex, Necrosis, Coagulative        |                                                                          |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6|                                            |            |
                                           | 1| 0| 9| 0| 2| 4| 5| 1| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  A  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  A  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      3  2.0|
      Clear Cell Focus                     |       2                                                                  |      3  1.3|
      Developmental Malformation           |             X                                                            |      8     |
      Fatty Change                         |    2                                                                     |      3  2.0|
      Inflammation, Chronic                |    1     1                 2                                             |     23  1.7|
      Bile Duct, Hyperplasia               |                   2                                                      |      6  1.7|
      Central Vein, Dilatation             |                                                                          |      1  1.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Periductular, Fibrosis               |                                                                          |      1  2.0|
      Periductular, Inflammation, Chronic  |                                                                          |      4  2.0|
      Sinusoid, Dilatation                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Fat, Inflammation, Chronic           |                                                                          |      1  2.0|
      Fat, Necrosis, Coagulative           |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      2  1.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Periductular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Submandibular Gland, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6|                                            |            |
                                           | 1| 0| 9| 0| 2| 4| 5| 1| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |       2           1                                                      |     13  1.7|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          | 1  1           1                                                         |      9  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Cyst                  |                      2                                                   |      4  2.3|
      Pars Distalis, Cyst Multilocular     |    2        2                                                            |      6  2.2|
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
      Pars Nervosa, Cyst                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Hyperplasia                  |                                                                          |      6  2.0|
      Follicle, Cyst                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  M  +                                             |  57        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Suppurative            |             4                                                            |      3  3.3|
      Duct, Dilatation                     |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicle, Cyst                       |                                                                          |      4  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6|                                            |            |
                                           | 1| 0| 9| 0| 2| 4| 5| 1| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                                          |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Prefemoral, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 4                                                                        |      1  4.0|
      Congestion                           |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      1  1.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Necrosis, Liquifactive               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  +  +  +  +  M                                             |  53        |
      Epithelial Cell, Cyst                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Galactocele                          |                                                                          |      3  3.0|
      Lactation                            |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
      Hypothalamus, Compression            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 0| 3| 5| 3| 3| 3| 0| 6|                                            |            |
                                           | 1| 0| 9| 0| 2| 4| 5| 1| 3| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Meninges, Inflammation, Chronic      |                                                                          |      1  2.0|
      Thalamus, Compression                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar Epithelium, Hyperplasia     | 3                                                                        |      3  2.0|
      Alveolus, Edema                      |                                                                          |      1  3.0|
      Alveolus, Hemorrhage                 |                                                                          |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |     10  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lumen, Fungus                        |                                                                          |      2  2.5|
      Lumen, Inflammation, Chronic         |                                                                          |      1  2.0|
      Lumen, Inflammation, Suppurative     |             2                                                            |      3  2.3|
      Mucosa, Inflammation, Chronic Active |       4                                                                  |      1  4.0|
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
      Lens, Cataract                       |          4                                                               |      1  4.0|
      Retina, Atrophy                      |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy                          | 2                                                                        |     22  1.1|
      Collecting Tubule, Mineralization    |                                                                          |      1  1.0|
      Cortex, Cyst                         |                                                                          |      1  3.0|
      Cortex, Necrosis, Coagulative        |                                                                          |      1  3.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  M  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|             
                                           | 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A     A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2                                             |             
      Basophilic Focus                     |                                              1                           |             
      Clear Cell Focus                     |                               1                                          |             
      Developmental Malformation           |                X  X                          X        X           X      |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                      1                                                   |             
      Inflammation, Chronic                |    2              2  1  2        3           1     2              2      |             
      Necrosis, Coagulative                |             2  3                                   1           3         |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                     1                                    |             
      Hepatocyte, Hyperplasia              |                                                    2                     |             
      Periductular, Fibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                +         |             
      Fat, Inflammation, Chronic           |                               3                                          |             
      Fat, Necrosis, Coagulative           |                                                                2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
      Atrophy                              |                      2                       2     1                     |             
      Ectopic Tissue                       |                                                             X            |             
      Hemorrhage, Chronic                  |       2                                                                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                         2        1                                2      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      Ulcer                                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      Ulcer                                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
      Hyperkeratosis                       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|             
                                           | 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 4                 1     2  2     2                                1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                4         |             
      Vacuolization Cytoplasmic            |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1           1                    1     1                       2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  A|             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      Pars Distalis, Cyst                  |                                              2     2                     |             
      Pars Distalis, Cyst Multilocular     |                                                                          |             
      Pars Distalis, Cytoplasmic Alteration|                                                                      1   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      C-Cell, Hyperplasia                  |                   1  2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              3                       3   |             
      Inflammation, Suppurative            |                                                                   4      |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                               4  3           2                           |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |       4                                         3                        |             
      Hyperplasia, Cystic                  |                                                       3                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |             +                                +                           |             
      Hyperkeratosis                       |                                              3                           |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|             
                                           | 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Plasma Cell   |                                     4                                    |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Necrosis, Coagulative   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      Hematopoietic Cell Proliferation     |                3                    2                                    |             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Hyperplasia, Plasma Cell             |                                                                3         |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Capsule, Hemorrhage                  | 4                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  M  +  +  +  +  +  +  M  +  +  +     +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      Galactocele                          |                                                                          |             
      Lactation                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       3  1               |             
      Hydrocephalus                        |                                                                          |             
      Necrosis, Liquifactive               |                                                       3                  |             
      Thalamus, Compression                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                   +  +  +  M  +                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                   +  I  +  +  +           M                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2              2|             
      Edema                                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| 7| 5| 3| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 5| 1| 4| 6| 0| 1| 3| 3| 3| 3| 3| 3| 1| 5| 1| 3| 6| 1| 8| 0| 3| 1| 3| 3| 7|             
                                           | 5| 6| 2| 2| 8| 0| 5| 4| 0| 0| 0| 4| 6| 7| 0| 0| 2| 7| 8| 0| 4| 0| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Inflammation, Chronic      |    2                                                                     |             
      Alveolus, Inflammation, Suppurative  |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Lumen, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Pigmentation, Porphyrin              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A|             
      Hydronephrosis                       |                                                                4         |             
      Nephropathy                          |                   1  1     1  1           2  1                       1   |             
      Pelvis, Inflammation, Chronic        |                                                          2               |             
      Pelvis, Mineralization               |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|             
                                           | 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    150MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  A  +        +  +  A  +  +  +  A  +     +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  A  +        +  +  +  +  +  +  +  +     +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  A  +        +  +  A  +  +  +  A  +     +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  A  +        +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            2     1                                2      |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           | X                                                                        |             
      Eosinophilic Focus                   |                                                       2                  |             
      Fatty Change                         |                                  1        2                 2  2         |             
      Inflammation, Chronic                | 2  2                       2           1                    1     1     2|             
      Necrosis, Coagulative                |       3                                                  4     1         |             
      Bile Duct, Hyperplasia               |       3                       4                    2     3               |             
      Centrilobular, Necrosis, Coagulative |             3                                                            |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Periductular, Fibrosis               |                               3                    1     2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +              +                                 |             
      Fat, Inflammation, Chronic           |                                        2                                 |             
      Fat, Necrosis, Coagulative           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  A  +        +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Atrophy                              |                2                       2                    1            |             
      Ectopic Tissue                       |                                                                          |             
      Hemorrhage, Chronic                  |                                                                          |             
      Hyperplasia                          |                                           3           2                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |                                                          4               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +        +  +  +  +  +  +  A  +     +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|             
                                           | 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    150MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1     3     2  2           2              2        1  1        1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |    2                                      2  3                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2  2     1              1  1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  A  +        +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Coagulative                |                                                          4               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +        +  +  +  +  M  M  M  +     +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  A  +        +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                  2     2                 3               |             
      Pars Distalis, Cyst Multilocular     | 2  2  3                                                              2   |             
      Pars Distalis, Cytoplasmic Alteration|                                                                          |             
      Pars Distalis, Hemorrhage            |                                                 1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +        +  +  +  +  M  +  A  +     +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +        +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                        3  2  4                           |             
      Duct, Dilatation                     |                            3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                               +                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hydrometra                           | 3                                                        3               |             
      Hyperplasia, Cystic                  |                                                             2            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +                             +           +               |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                          4               |             
      Inflammation, Suppurative            |                4                                         4               |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|             
                                           | 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    150MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mediastinal, Hemorrhage              |       3                                                                  |             
      Mediastinal, Necrosis, Coagulative   |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                    2                 3   |             
      Hyperplasia, Plasma Cell             |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                              2                           |             
      Necrosis, Coagulative                |                                                          4               |             
      Capsule, Hemorrhage                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Galactocele                          |                                  3                                       |             
      Lactation                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  A  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Necrosis, Liquifactive               |                                                                          |             
      Thalamus, Compression                |                                                                   X      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                       +     +     +  +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                       +     +     +  +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |          3                          2                                    |             
      Alveolar Epithelium, Hyperplasia     |       3                                                  1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 5| 4| 4| 4| 6| 7| 5| 6| 0| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 0| 3| 7| 6| 6| 1| 2| 9| 8| 4| 2| 6| 5| 6| 3| 3| 0| 3| 6| 3| 4| 3|             
                                           | 1| 0| 0| 6| 7| 1| 1| 2| 2| 9| 0| 2| 9| 9| 7| 7| 1| 1| 4| 1| 1| 4| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    150MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Lumen, Inflammation, Suppurative     |                                              3                    2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                         +                                                |             
      Pigmentation, Porphyrin              |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                3                                                         |             
      Nephropathy                          | 1                       1  1     1     1           2  1  1           1  1|             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Pelvis, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +        +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 5| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6|                                            |            |
                                           | 4| 1| 8| 5| 1| 3| 1| 1| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +                                                      |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +                                                      |  43        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +                                                      |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +                                                      |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +                                                      |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +                                                      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +                                                      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +                                                      |  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +                                                      |  52        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      4  1.5|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Developmental Malformation           |                                                                          |      6     |
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Fatty Change                         |    4     3                                                               |      7  2.1|
      Inflammation, Chronic                | 2        1        2                                                      |     18  1.7|
      Necrosis, Coagulative                |                                                                          |      7  2.4|
      Bile Duct, Hyperplasia               |    2                                                                     |      5  2.8|
      Centrilobular, Necrosis, Coagulative |                                                                          |      2  2.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Periductular, Fibrosis               |    2                                                                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Inflammation, Chronic           |                                                                          |      2  2.5|
      Fat, Necrosis, Coagulative           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +                                                      |  46        |
      Atrophy                              |       1                                                                  |      7  1.6|
      Ectopic Tissue                       |                                                                          |      1     |
      Hemorrhage, Chronic                  |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +                                                      |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +                                                      |  49        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +                                                      |  48        |
      Ulcer                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 5| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6|                                            |            |
                                           | 4| 1| 8| 5| 1| 3| 1| 1| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +                                                      |  51        |
      Cardiomyopathy                       |    3                                                                     |     16  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +                                                      |  51        |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +                                                      |  51        |
      Hyperplasia                          |                                                                          |     10  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +                                                      |  46        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +     +  +                                                      |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +                                                      |  49        |
      Pars Distalis, Cyst                  |       2                                                                  |      6  2.2|
      Pars Distalis, Cyst Multilocular     |                                                                          |      4  2.3|
      Pars Distalis, Cytoplasmic Alteration|                                                                          |      1  1.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +                                                      |  48        |
      C-Cell, Hyperplasia                  |                   1                                                      |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +     +  +                                                      |  50        |
      Hyperplasia                          |                   2                                                      |      4  2.5|
      Inflammation, Suppurative            |                                                                          |      4  3.3|
      Duct, Dilatation                     |          2                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +                                                      |  51        |
      Follicle, Cyst                       |                3                                                         |      4  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +                                                |  54        |
      Hydrometra                           |                4  3                                                      |      6  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 5| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6|                                            |            |
                                           | 4| 1| 8| 5| 1| 3| 1| 1| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   5        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +                                                      |  50        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +                                                      |  51        |
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  4.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Necrosis, Coagulative   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +                                                      |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +                                                      |  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +                                                      |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Capsule, Hemorrhage                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +     +  +                                                      |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +                                                      |  50        |
      Galactocele                          |          3                                                               |      2  3.0|
      Lactation                            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +                                                      |  51        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +                                                      |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 5| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 9| 1| 1| 6| 1| 3| 6| 6| 6|                                            |            |
                                           | 4| 1| 8| 5| 1| 3| 1| 1| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    150MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +                                                      |  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hydrocephalus                        |          3                                                               |      1  3.0|
      Necrosis, Liquifactive               |                                                                          |      1  3.0|
      Thalamus, Compression                |          3                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   9        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +                                                      |  52        |
      Congestion                           |                                                                          |      2  2.0|
      Edema                                |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |             1                                                            |      4  1.8|
      Alveolus, Inflammation, Chronic      |                                                                          |      1  2.0|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +                                                      |  51        |
      Lumen, Inflammation, Suppurative     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +                                                      |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Pigmentation, Porphyrin              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +                                                      |  50        |
      Hydronephrosis                       |                                                                          |      2  3.5|
      Nephropathy                          | 1  1     1  1                                                            |     21  1.1|
      Pelvis, Inflammation, Chronic        |                                                                          |      1  2.0|
      Pelvis, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +                                                      |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|             
                                           | 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        A|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        A|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +     +  +  +  +  +  +  A  +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +     +  +  +  +  +  +  A  +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Clear Cell Focus                     |                                                 2  1                     |             
      Congestion                           |             2                                                            |             
      Developmental Malformation           |                                        X                 X               |             
      Fatty Change                         |                               2        1                                 |             
      Inflammation, Chronic                |          2  1        1     1  1     2           2     2     2            |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis, Coagulative                |                      1           2                                       |             
      Bile Duct, Hyperplasia               |                                                                1         |             
      Hepatocyte, Hyperplasia              |          2                          2                                    |             
      Periductular, Fibrosis               |                                                                      1   |             
      Periductular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                    +         |             
      Fat, Necrosis, Coagulative           |                                           2                    2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Atrophy                              |             2                    2                                       |             
      Ectopic Tissue                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                             3            |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Dilatation                   |                                                                2         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                     +                                    |             
      Hyperplasia, Squamous                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|             
                                           | 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Cardiomyopathy                       |                      2     2     2  2  2  1           2        2        1|             
      Atrioventricular Valve, Fibrosis     |                   3                                                      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Hyperplasia                          |             2        2           1                 1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +     M  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +|             
      Pars Distalis, Cyst                  |       3                                                     2            |             
      Pars Distalis, Cyst Multilocular     |                      2                                                   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                            2                                             |             
      Pars Intermedia, Hemorrhage          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      C-Cell, Hyperplasia                  |                3                 2                                       |             
      Follicle, Cyst                       | 2                                                                        |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Hyperplasia                          |                      3                                                   |             
      Inflammation, Suppurative            |          2           3        3                                          |             
      Duct, Dilatation                     |                                                                          |             
      Duct, Inflammation, Suppurative      |                                                       3                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hydrometra                           |                3                                   3                 3   |             
      Hyperplasia, Cystic                  |    3                 2                             3                     |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|             
                                           | 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lumbar, Pigmentation, Hemosiderin    |                                                                          |             
      Mediastinal, Hyperplasia, Macrophage |                                                                          |             
      Prefemoral, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Congestion                           |                                  2                                       |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  M  +     +  +        +|             
      Galactocele                          |                                                                          |             
      Lactation                            |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        A|             
      Hydrocephalus                        |                                                                          |             
      Hypothalamus, Compression            |                                                                3         |             
      Thalamus, Compression                |                                                       3                  |             
      Thalamus, Necrosis, Coagulative      |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 6| 5| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 5| 4| 4| 7|             
                             DAY ON TEST   | 3| 6| 6| 2| 3| 1| 8| 2| 6| 3| 3| 1| 3| 3| 3| 9| 3| 3| 7| 6| 3| 5| 6| 6| 0|             
                                           | 0| 7| 1| 9| 4| 1| 0| 4| 1| 0| 4| 0| 0| 4| 4| 2| 1| 1| 2| 2| 0| 2| 1| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Iris, Synechia                       |                         4                                                |             
      Lens, Cataract                       |                                                                          |             
      Posterior Chamber, Hemorrhage        |                                                                          |             
      Retina, Dysplasia                    |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Nephropathy                          |             1     1  1     1  2  1  1  2  2     1  1  1     1  2  1     2|             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Inflammation, Chronic        | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +        +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|             
                                           | 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Inflammation, Suppurative            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Ulcer                                |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Clear Cell Focus                     |       1  3              2                                                |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |    X     X                                                               |             
      Fatty Change                         |                            1     3        1     3                        |             
      Inflammation, Chronic                |             2     1        1  2     2     1                 1     3      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |             2                    2                                       |             
      Bile Duct, Hyperplasia               |             2                    2              3                        |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Periductular, Fibrosis               |                                                                          |             
      Periductular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fat, Necrosis, Coagulative           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Atrophy                              |                                                 2                        |             
      Ectopic Tissue                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |          3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Erosion                              |          2                                                               |             
      Inflammation, Chronic                |          2                                                               |             
      Mucosa, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|             
                                           | 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Cardiomyopathy                       |    1           3  2                    2  1  2           2  1            |             
      Atrioventricular Valve, Fibrosis     |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +     +  +     +     +|             
      Angiectasis                          |                                                          3               |             
      Hemorrhage                           |                                                                   4      |             
      Infarct                              |                                              2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +     +  +     +     +|             
      Hyperplasia                          |                                           1                       1     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  M     +  +     +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +     +     +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst Multilocular     |                                                             2            |             
      Pars Distalis, Hemorrhage            |                                                                   4      |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pars Intermedia, Hemorrhage          |                                                                   4      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +|             
      C-Cell, Hyperplasia                  |    2  2                       2                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Hyperplasia                          |                                              2                           |             
      Inflammation, Suppurative            |    4                                            3                        |             
      Duct, Dilatation                     |       3     3                                                            |             
      Duct, Inflammation, Suppurative      |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Follicle, Cyst                       |    3     3                                                  2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hydrometra                           |                                        3                       4        3|             
      Hyperplasia, Cystic                  |    2  2                             4                                    |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|             
                                           | 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hyperplasia, Lymphoid                |                3                                                         |             
      Lumbar, Pigmentation, Hemosiderin    |                                                       2                  |             
      Mediastinal, Hyperplasia, Macrophage |                                        2                                 |             
      Prefemoral, Hyperplasia, Lymphoid    |                                                          4               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Congestion                           |                            3                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Congestion                           |             3                    3                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Galactocele                          |          2              4  X                                             |             
      Lactation                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Hydrocephalus                        |          3                                                               |             
      Hypothalamus, Compression            |                                                                          |             
      Thalamus, Compression                |    4                                                                     |             
      Thalamus, Necrosis, Coagulative      | 3                                                                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | M  +                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Alveolar Epithelium, Hyperplasia     |                                  2           2                           |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Lumen, Fungus                        |                                                                   4      |             
      Lumen, Inflammation, Suppurative     |    2                                                                     |             
      Mucosa, Inflammation, Suppurative    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 5| 6| 4| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 9| 3| 2| 1| 3| 6| 3| 3| 3| 2| 3| 3| 3| 8| 3| 8| 9| 7| 6| 1| 3| 6| 3| 6| 3|             
                                           | 6| 3| 9| 8| 0| 2| 5| 1| 0| 9| 4| 1| 4| 9| 0| 0| 5| 8| 2| 7| 4| 1| 5| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    300MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Iris, Synechia                       |                                                                          |             
      Lens, Cataract                       |    4                                                                     |             
      Posterior Chamber, Hemorrhage        |                                                                          |             
      Retina, Dysplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Nephropathy                          |    1  1  3  1     1  2  1  1  1  1  1  1  1  1              1     1      |             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Infiltration Cellular, Lymphocyte    |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8|                                            |            |
                                           | 4| 2| 1| 0| 7| 0| 5| 1| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +     +  A                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  A                                             |  47        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  A                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  A                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +     +  A                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  A                                             |  47        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  A                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  A                                             |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +     +  +                                             |  52        |
      Clear Cell Focus                     |       1                                                                  |      6  1.7|
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |          X                 X                                             |      6     |
      Fatty Change                         |                                                                          |      6  1.8|
      Inflammation, Chronic                |       1  1  2                                                            |     20  1.6|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      4  1.8|
      Bile Duct, Hyperplasia               |    2                                                                     |      5  2.0|
      Hepatocyte, Hyperplasia              |                                                                          |      2  2.0|
      Periductular, Fibrosis               |                                                                          |      1  1.0|
      Periductular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                         1                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   4        |
      Fat, Necrosis, Coagulative           |                         3                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +     +  A                                             |  49        |
      Atrophy                              |    2              2                                                      |      5  2.0|
      Ectopic Tissue                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +                                             |  50        |
      Hyperkeratosis                       |    2                                                                     |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                         4                                                |      1  4.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  A                                             |  48        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8|                                            |            |
                                           | 4| 2| 1| 0| 7| 0| 5| 1| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Dilatation                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +     +  +                                             |  51        |
      Cardiomyopathy                       |                         2                                                |     18  1.8|
      Atrioventricular Valve, Fibrosis     |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +                                             |  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +                                             |  49        |
      Hyperplasia                          |                   1                                                      |      8  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  M                                             |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +                                             |  52        |
      Pars Distalis, Cyst                  | X                                                                        |      3  2.5|
      Pars Distalis, Cyst Multilocular     |                                                                          |      2  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
      Pars Intermedia, Hemorrhage          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +     +  A                                             |  50        |
      C-Cell, Hyperplasia                  |       1  2                                                               |      7  2.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicle, Dilatation                 |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +     +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      5  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8|                                            |            |
                                           | 4| 2| 1| 0| 7| 0| 5| 1| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Dilatation                     |                                                                          |      2  3.0|
      Duct, Inflammation, Suppurative      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +     +  +                                             |  50        |
      Follicle, Cyst                       |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hydrometra                           |                                                                          |      6  3.2|
      Hyperplasia, Cystic                  |                                                                          |      6  2.7|
      Cervix, Inflammation, Suppurative    |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +     +  +                                             |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Lumbar, Pigmentation, Hemosiderin    |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Macrophage |                                                                          |      1  2.0|
      Prefemoral, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  A                                             |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +                                             |  50        |
      Congestion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +     +  A                                             |  49        |
      Congestion                           |                                                                          |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +     +  +                                             |  49        |
      Galactocele                          |                                                                          |      3  3.0|
      Lactation                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +     +  A                                             |  48        |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Hypothalamus, Compression            |    3                    3                                                |      3  3.0|
      Thalamus, Compression                |                                                                          |      2  3.5|
      Thalamus, Necrosis, Coagulative      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 4| 5| 3|                                            |            |
                             DAY ON TEST   | 2| 2| 3| 3| 1| 3| 9| 6| 3| 8|                                            |            |
                                           | 4| 2| 1| 0| 7| 0| 5| 1| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    300MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                 +                                                      |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                   +                                                      |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +     +  +                                             |  50        |
      Alveolar Epithelium, Hyperplasia     |                1                                                         |      3  1.7|
      Alveolus, Inflammation, Chronic      |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +     +  +                                             |  50        |
      Lumen, Fungus                        |                         3                                                |      2  3.5|
      Lumen, Inflammation, Suppurative     |                                                                          |      1  2.0|
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   3        |
      Iris, Synechia                       |                                                                          |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  4.0|
      Posterior Chamber, Hemorrhage        | 4                                                                        |      1  4.0|
      Retina, Dysplasia                    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +     +  A                                             |  50        |
      Nephropathy                          |    1  1  1  1  3  1                                                      |     38  1.3|
      Cortex, Cyst                         |                         2                                                |      1  2.0|
      Pelvis, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +     +  A                                             |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|             
                                           | 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                            2  1           1                    1         |             
      Congestion                           |                                                       3                  |             
      Developmental Malformation           | X                                                              X         |             
      Eosinophilic Focus                   |                                  X                                       |             
      Fatty Change                         |                                                                          |             
      Inflammation, Chronic                | 1     1  2                    1           2                             1|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                              2           2               |             
      Bile Duct, Hyperplasia               |                      1                 2     2  2                        |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |             
      Hepatocyte, Hyperplasia              |                   1                                                      |             
      Periductular, Fibrosis               |                                        2     2                           |             
      Periductular, Inflammation, Chronic  |                2                                                         |             
      Periductular, Inflammation,          |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis, Coagulative           | 3                                                                        |             
      Fat, Necrosis, Liquifactive          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                        1               |             
      Inflammation, Chronic                |                                                                          |             
      Interstitium, Fibrosis               |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                    2                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|             
                                           | 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                             2            |             
      Ulcer                                |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             2                 1  2           2     2     3  2            |             
      Atrium, Thrombosis                   |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3                                       |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                   1                    1     3        1        2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Pars Distalis, Cyst                  |       3           2           2                                          |             
      Pars Distalis, Hemorrhage            |                                     3                                    |             
      Pars Distalis, Hyperplasia           |             2                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                           2                    1         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      3   |             
      Duct, Dilatation                     |                                                       3                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                          X               |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |       2                                         3                    3  3|             
      Hyperplasia, Cystic                  |                                                             2        4   |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                   +                  |             
      Inflammation, Suppurative            |                   3                                   2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|             
                                           | 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |             
      Mediastinal, Congestion              |                                                       2                  |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3        3  3               |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Pigmentation, Hemosiderin            |                   3     3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        | X                                                                        |             
      Tail, Hyperkeratosis                 |                                                                          |             
      Tail, Inflammation, Suppurative      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Cerebellum, Gliosis                  |                                                                          |             
      Thalamus, Compression                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 4| 4| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 4| 4| 6| 6| 6| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 3| 6| 3| 3| 3| 3| 6| 1| 3| 1| 6| 6| 3| 1| 1| 3| 4| 3| 2|             
                                           | 4| 3| 4| 4| 2| 1| 9| 1| 9| 1| 0| 0| 2| 0| 1| 0| 2| 2| 1| 8| 8| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Foreign Body               |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                                      1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Lumen, Inflammation, Suppurative     |                   2     2                                                |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1        2              1     1           1  2        1  2  1  1     1  1|             
      Pelvis, Inflammation, Chronic        |                                  2                                       |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|             
                                           | 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Clear Cell Focus                     |          2                                         1        2            |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |          X                                                               |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Inflammation, Chronic                |          1        2                                                      |             
      Mixed Cell Focus                     |                                                                   X      |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               |                                  1                                   3   |             
      Centrilobular, Necrosis, Coagulative |                                              2                       1   |             
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Periductular, Fibrosis               |                                                                          |             
      Periductular, Inflammation, Chronic  |                               1                 1                        |             
      Periductular, Inflammation,          |                                                                          |             
          Suppurative                      |                                  1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +                       +                           |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis, Coagulative           |                      3                                                   |             
      Fat, Necrosis, Liquifactive          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |                                     1                                4   |             
      Inflammation, Chronic                |       2                                                                  |             
      Interstitium, Fibrosis               |                               2                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Fibrosis                             |                2                                                         |             
      Hyperplasia, Squamous                |    2           1                                                         |             
      Inflammation, Chronic                |    2  3                                                                  |             
      Mineralization                       |                               2                                         2|             
      Ulcer                                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|             
                                           | 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Cardiomyopathy                       | 2        2     2                                                         |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hyperplasia                          |                                           1                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Pars Distalis, Cyst                  | 3                 2                                         2            |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Suppurative            |          4                                         3                     |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Follicle, Cyst                       |                                                    3  X                  |             
                                            __________________________________________________________________________|             
   Oviduct                                 |    +                    +                                         +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                 4                       3|             
      Hyperplasia, Cystic                  |          4                                                               |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
      Inflammation, Suppurative            |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|             
                                           | 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lumbar, Hyperplasia, Histiocytic     |    3                                                                     |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|    3                                                                     |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Hyperplasia, Lymphoid                | 3                                                                 3      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Reticulum Cell          |    2                                                                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                                                                          |             
      Tail, Hyperkeratosis                 |                                           3                              |             
      Tail, Inflammation, Suppurative      |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemorrhage                           |                         3                                                |             
      Hydrocephalus                        |                                                                          |             
      Cerebellum, Gliosis                  |                                                                          |             
      Thalamus, Compression                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +                                                           +            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                     +     +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 5| 7| 5| 7| 7| 5| 0| 5| 4| 5| 5| 3| 7| 5| 4| 7| 6| 5| 7| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 5| 9| 2| 3| 1| 3| 2| 9| 0| 6| 9| 3| 3| 3| 5| 6| 3| 3| 0| 3| 3| 0| 8| 6|             
                                           | 4| 5| 6| 9| 1| 1| 1| 1| 0| 6| 2| 1| 5| 1| 4| 3| 1| 1| 8| 4| 0| 0| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                         3|             
      Alveolus, Foreign Body               |                      3  1                                                |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |                      4                                                   |             
      Lumen, Inflammation, Suppurative     |    2                       2                                             |             
      Mucosa, Inflammation, Suppurative    |             3                                                           2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Lens, Cataract                       | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Nephropathy                          |       4  1     1  2        2        1     3        1  1     2  1  2  1  1|             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3|                                            |            |
                                           | 0| 7| 4| 9| 8| 1| 4| 0| 8| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Clear Cell Focus                     |                            2                                             |      8  1.5|
      Congestion                           |                                                                          |      1  3.0|
      Developmental Malformation           |    X                                                                     |      4     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change                         |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |                   1  1                                                   |     10  1.3|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Coagulative                |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |                3                                                         |      7  2.0|
      Centrilobular, Necrosis, Coagulative |                                                                          |      2  1.5|
      Hepatocyte, Cytoplasmic Alteration   |                         3                                                |      1  3.0|
      Hepatocyte, Hyperplasia              |          2                                                               |      2  1.5|
      Periductular, Fibrosis               |                                                                          |      2  2.0|
      Periductular, Inflammation, Chronic  |                                                                          |      3  1.3|
      Periductular, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +                                                      |   6        |
      Fat, Inflammation, Chronic Active    |                   4                                                      |      1  4.0|
      Fat, Necrosis, Coagulative           |                3                                                         |      3  3.0|
      Fat, Necrosis, Liquifactive          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                            2                                             |      5  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Interstitium, Fibrosis               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3|                                            |            |
                                           | 0| 7| 4| 9| 8| 1| 4| 0| 8| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      3  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |       3           4                                                      |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       |                                                                          |     10  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |    2                    1                                                |      8  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  53        |
      Hyperplasia                          |       2                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  | 2                       2                                                |      8  2.3|
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Hyperplasia                  |                                                                          |      2  1.5|
      Follicle, Cyst                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |       2                                                                  |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3|                                            |            |
                                           | 0| 7| 4| 9| 8| 1| 4| 0| 8| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Dilatation                     |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicle, Cyst                       |    3                                                                     |      4  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |       3  3                                                               |      8  3.0|
      Hyperplasia, Cystic                  |                                                                          |      3  3.3|
      Cervix, Inflammation, Suppurative    |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Inflammation, Suppurative            |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                3                                                         |      3  3.0|
      Hyperplasia, Plasma Cell             |       3                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Congestion                           |                4                                                         |      4  3.3|
      Developmental Malformation           |                X                                                         |      1     |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | I  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                                                                          |      1     |
      Tail, Hyperkeratosis                 |                                                                          |      1  3.0|
      Tail, Inflammation, Suppurative      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 1| 3| 2| 0| 3| 3| 3| 7| 3|                                            |            |
                                           | 0| 7| 4| 9| 8| 1| 4| 0| 8| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    600MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |       3                                                                  |      1  3.0|
      Cerebellum, Gliosis                  |          1                                                               |      1  1.0|
      Thalamus, Compression                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Alveolus, Foreign Body               |                                                                          |      2  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  4.0|
      Lumen, Inflammation, Suppurative     |                   1                                                      |      5  1.8|
      Mucosa, Inflammation, Suppurative    |                                                                          |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Nephropathy                          |       2  1        1  1  2  1                                             |     32  1.4|
      Pelvis, Inflammation, Chronic        |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Developmental Malformation           | X                                                                        |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|             
                                           | 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                             1            |             
      Congestion                           | 2                                                                        |             
      Cytologic Alterations                |                                                             1            |             
      Developmental Malformation           |    X  X                                X                                 |             
      Fatty Change                         |                                     1           2                 1      |             
      Inflammation, Chronic                |                                                             1            |             
      Inflammation, Suppurative            |                                  2                                       |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  1              2     1  2     2  2  2        3     2  1     1     2|             
      Centrilobular, Necrosis, Coagulative |                                                       1                  |             
      Periductular, Fibrosis               |                                           2        2              1     2|             
      Periductular, Inflammation, Chronic  |                      2                                                   |             
      Periportal, Necrosis, Coagulative    |                                                                          |             
      Periportal, Pigmentation, Hemosiderin|                                              2                           |             
      Portal, Pigmentation, Hemosiderin    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +              +  +           +           +           +|             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Inflammation, Suppurative       |                                                 2                        |             
      Fat, Necrosis, Coagulative           |                                  1  2                                   3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Atrophy                              |                   3                    2  2              2        2      |             
      Inflammation, Chronic                |                                  2                                       |             
      Acinar Cell, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia, Squamous                |                                              1                           |             
      Inflammation, Chronic                |                                              1                           |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                1  3                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|             
                                           | 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2     2     3  2  2  2  2  2  2     2        2     2  2     3  3   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                           2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                            1                             2               |             
      Necrosis, Coagulative                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                   2                                                      |             
      Pars Distalis, Cyst Multilocular     |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                    1                     |             
      Pars Intermedia, Cyst                |                               3                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     2                                    |             
      Follicle, Hyperplasia                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                        +                                 |             
      Inflammation, Suppurative            |                                        4                                 |             
      Lumen, Dilatation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3  2                             2               |             
      Inflammation, Chronic                |                                  3                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                       3                 2|             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                 4                    1  3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|             
                                           | 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                        4        4                        |             
      Lumen, Dilatation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                 2     2                  |             
      Hyperplasia, Plasma Cell             |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |             2                       3                                    |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Chronic                |             3                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                     X                                    |             
      Inflammation, Chronic                |                                  2                                       |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Compression                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                              +                           |             
      Degeneration, Secondary Wallerian    |                                              2                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                           2                             1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 4| 4| 7| 7| 7| 3| 5| 7| 6| 7| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 2| 2| 1| 4| 5| 3| 2| 5| 5| 2| 2| 2| 7| 3| 3| 1| 3| 2| 4| 9| 2| 1|             
                                           | 0| 9| 0| 6| 9| 1| 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 4| 0| 9| 0| 9| 5| 0| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Edema                      |                                                                2         |             
      Alveolus, Inflammation, Chronic      |                                                             1            |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                           3                              |             
      Metaplasia, Squamous                 |                                                                          |             
      Lumen, Foreign Body                  |                                                                2         |             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                           3        2                     |             
      Mucosa, Inflammation, Suppurative    |                                        2                                 |             
      Mucosa, Septum, Inflammation, Chronic|                                                 3                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Anterior Chamber, Hemorrhage, Chronic|                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Nephropathy                          | 2  2  2  2  3  2  1  1  3  2  1  1  2  2  2  1  1  2  1  4  2     2  2  3|             
      Cortex, Cyst                         |             2                                                            |             
      Pelvis, Inflammation, Suppurative    |                                                 4                        |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                         1                                                |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                 +                        |             
      Mucosa, Inflammation, Suppurative    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Submucosa, Inflammation, Suppurative |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|             
                                           | 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                         1  1                                             |             
      Congestion                           |                                                                          |             
      Cytologic Alterations                |                                                                          |             
      Developmental Malformation           |    X     X                                         X                     |             
      Fatty Change                         |    1                             2  2                 2                  |             
      Inflammation, Chronic                |                            1              2  1                       1   |             
      Inflammation, Suppurative            |                                                                          |             
      Mixed Cell Focus                     |                   X                                                      |             
      Bile Duct, Hyperplasia               | 2        2  2  2  2              2  1     2        2  2     2           2|             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Periductular, Fibrosis               |                                  2                    1                 1|             
      Periductular, Inflammation, Chronic  |                                                             2            |             
      Periportal, Necrosis, Coagulative    |                1                                                         |             
      Periportal, Pigmentation, Hemosiderin|                                                                          |             
      Portal, Pigmentation, Hemosiderin    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +  +                          +        +  +     +           +      |             
      Fat, Inflammation, Chronic           |                                                                   3      |             
      Fat, Inflammation, Granulomatous     |                                              2                           |             
      Fat, Inflammation, Suppurative       |                                                                          |             
      Fat, Necrosis, Coagulative           | 3     3  4                          2           4     3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2           2     2  2      |             
      Inflammation, Chronic                |                                                                          |             
      Acinar Cell, Hyperplasia             |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                              X                           |             
      Hyperplasia, Squamous                |                      3           2                                       |             
      Inflammation, Chronic                |                      3           1                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|             
                                           | 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                        1                                 |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     3  2  2  2  2     2  1  2  2  2     2  2  3  2  2  3  3  3        2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       3                  |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                      2   |             
      Pars Distalis, Cyst Multilocular     |                                        2                                 |             
      Pars Distalis, Hyperplasia           |                               2                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1                                                      |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Lumen, Dilatation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                     3                                    |             
      Inflammation, Suppurative            |                      3                                                   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Inflammation, Suppurative            |    2              4     2  2     2           2                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|             
                                           | 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                   3                                                      |             
      Lumen, Dilatation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                  2                                       |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                          2                                          |             
      Congestion                           | 3                             2                                          |             
      Developmental Malformation           |                                                    X                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Thalamus, Compression                |                                  3        3                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                +                                                         |             
      Degeneration, Secondary Wallerian    |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |             1                                                           2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 7| 4| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 5| 3| 0| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 5| 5| 3| 5| 2| 2| 5| 5| 5| 4| 2| 3|             
                                           | 5| 0| 5| 0| 9| 0| 9| 6| 9| 9| 0| 4| 9| 4| 4| 0| 6| 9| 9| 8| 9| 8| 1| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                       1                  |             
      Alveolus, Inflammation, Suppurative  | 2                                                                 3      |             
      Bronchiole, Inflammation, Suppurative|    1                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Metaplasia, Squamous                 |                                           2                              |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Fungus                        | 3                          4  3                                          |             
      Lumen, Inflammation, Suppurative     | 3                       2  4  2           2                       2      |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Mucosa, Septum, Inflammation, Chronic|                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Anterior Chamber, Hemorrhage, Chronic|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  3  3  2  2  3  3  1  4  2  2  2  2  1  2  3  1  2  2  1  1  1  2  3  2|             
      Cortex, Cyst                         |                   3                                                  3   |             
      Pelvis, Inflammation, Suppurative    |                   3                                                      |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                   1                                                      |             
      Submucosa, Inflammation, Suppurative |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 6| 6| 6| 7| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5|                                            |            |
                                           | 8| 7| 0| 8| 0| 8| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  A  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  A  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  A  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  A  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  A  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  M  +  A  +  +  A  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  M  +  +  A  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Basophilic Focus                     | 2                 2                                                      |      2  2.0|
      Clear Cell Focus                     |                                                                          |      3  1.0|
      Congestion                           |                                                                          |      1  2.0|
      Cytologic Alterations                |                                                                          |      1  1.0|
      Developmental Malformation           |                                                                          |      6     |
      Fatty Change                         |    2        2                                                            |      9  1.7|
      Inflammation, Chronic                |                            2                                             |      6  1.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Bile Duct, Hyperplasia               |                2     2     2                                             |     29  1.9|
      Centrilobular, Necrosis, Coagulative |                         3                                                |      2  2.0|
      Periductular, Fibrosis               |                                                                          |      7  1.6|
      Periductular, Inflammation, Chronic  | 2                    2                                                   |      4  2.0|
      Periportal, Necrosis, Coagulative    |                                                                          |      1  1.0|
      Periportal, Pigmentation, Hemosiderin|                                                                          |      1  2.0|
      Portal, Pigmentation, Hemosiderin    |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +        +  +                                                         |  19        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      1  2.0|
      Fat, Inflammation, Suppurative       |                                                                          |      1  2.0|
      Fat, Necrosis, Coagulative           | 3  4        3  2                                                         |     13  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      9  2.1|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinar Cell, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +                                             |  56        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 6| 6| 6| 7| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5|                                            |            |
                                           | 8| 7| 0| 8| 0| 8| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      3  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Inflammation, Suppurative            |             3                                                            |      1  3.0|
      Ulcer                                |    3        2                                                            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +                                             |  55        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Cardiomyopathy                       | 3  2  2     2  2  2  2     2                                             |     45  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Basophilic Focus                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |                   2                                                      |      3  1.7|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  A  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
      Pars Distalis, Cyst Multilocular     |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      2  1.5|
      Pars Intermedia, Cyst                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Hyperplasia                  |                                                                          |      2  1.5|
      Follicle, Hyperplasia                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                   +                                                      |   2        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Lumen, Dilatation                    |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 6| 6| 6| 7| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5|                                            |            |
                                           | 8| 7| 0| 8| 0| 8| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  M  +  M  +  +  +  +                                             |  56        |
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |    2                                                                     |      4  2.5|
      Duct, Dilatation                     | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      9  2.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Suppurative            |                                                                          |      3  3.7|
      Lumen, Dilatation                    |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |    4              3        2                                             |      4  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 3                          3                                             |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M                                             |  59        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      4  2.5|
      Developmental Malformation           |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 6| 6| 6| 7| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5|                                            |            |
                                           | 8| 7| 0| 8| 0| 8| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Thalamus, Compression                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
      Degeneration, Secondary Wallerian    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  M  +                                             |  59        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.5|
      Alveolus, Edema                      |                                                                          |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |      2  1.0|
      Alveolus, Inflammation, Suppurative  |                                                                          |      2  2.5|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fungus                               |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
      Lumen, Fungus                        |                                                                          |      3  3.3|
      Lumen, Inflammation, Suppurative     |                                                                          |      8  2.5|
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Mucosa, Septum, Inflammation, Chronic|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Anterior Chamber, Hemorrhage, Chronic|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Nephropathy                          | 1  3  3  1  2  2  3  1  2  1                                             |     59  2.0|
      Cortex, Cyst                         |                                                                          |      3  2.7|
      Pelvis, Inflammation, Suppurative    |                                                                          |      2  3.5|
      Renal Tubule, Hyperplasia, Cystic    |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 6| 6| 6| 7| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 7| 7| 4| 2| 5| 0| 5|                                            |            |
                                           | 8| 7| 0| 8| 0| 8| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  1.0|
      Submucosa, Inflammation, Suppurative |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|             
                                           | 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
      Circumanal Gland, Hyperplasia,       |                                                                          |             
          Glandular                        |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  A  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  A  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +     +  +  +  +     M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  A  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  A  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Developmental Malformation           |                                        X           X                     |             
      Fatty Change                         |                                                    1              1      |             
      Infiltration Cellular, Histiocyte    |             2                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               | 2     2     2  1  2  2        2  1                    3           1      |             
      Centrilobular, Necrosis, Coagulative |                                                          2               |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Periductular, Fibrosis               | 2                             2     2           1                        |             
      Periductular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Periductular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                       +              +  +     +     +     +|             
      Fat, Inflammation, Chronic           |                                                       3                  |             
      Fat, Inflammation, Fibrinopurulent   |                                                    4                     |             
      Fat, Necrosis, Coagulative           |       2     3                       2                             3     2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3              2                                                         |             
      Ectopic Tissue                       |                                                             X            |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia, Squamous                |                                  3              3  2     1  3     1      |             
      Inflammation, Chronic                |                                  2              4  3     1               |             
      Ulcer                                |    4              2           4        3                             3  4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|             
                                           | 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                      1   |             
      Hemorrhage                           |                                                 1                        |             
      Inflammation, Chronic                |                               1                                      3   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                         3|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3     2     2  1  2  2  2     3  2  2  2     2     1  3  1              3|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Hemorrhage                           |                                              3                           |             
      Vacuolization Cytoplasmic            |                                  3     3           3     2              3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                    2                     |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  M  +  +     +  +  +  +     M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2        2        2        2        2  2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    4                                                                     |             
      Pars Distalis, Cyst                  |                                  3                       3               |             
      Pars Distalis, Cyst Multilocular     | 2                                                                        |             
      Pars Distalis, Hemorrhage, Chronic   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         1                                               1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       M                  |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          3               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |    4                    4                                4     3        3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|             
                                           | 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     |                                                 3                        |             
      Duct, Inflammation, Suppurative      |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       3           4  3  2              3           4                 3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 4                        |             
      Polyarteritis                        |                                  3                                       |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia, Plasma Cell      |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Plasma Cell             |                   3              2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         3                                                |             
      Developmental Malformation           |                                  X                                       |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |             2                                         3                  |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Perivascular, Fibrosis               |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                                               |             
      Hemorrhage                           |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  M  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Ulcer                                |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 6| 7| 5| 5| 7| 4| 7| 7| 7| 6| 4| 2| 6| 7| 5| 6| 5| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 6| 4| 7| 3| 2| 5| 4| 2| 5| 2| 3| 2| 9| 5| 3| 8| 2| 7| 6| 5| 3| 2| 5| 6|             
                                           | 9| 2| 3| 3| 4| 9| 7| 9| 9| 8| 3| 0| 9| 5| 8| 8| 5| 1| 6| 8| 0| 0| 9| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +     A  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                               |             
      Meninges, Congestion                 |       2                                                                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +           +              +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                      2                                               3   |             
      Alveolus, Edema                      |       3                                                                  |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Inflammation, Suppurative  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                                                    3                     |             
      Lumen, Inflammation, Suppurative     |       2                 2        2     2           3                     |             
      Mucosa, Inflammation, Suppurative    |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Perforation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Bilateral, Lens, Cataract            |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 4  4  2  2  2  4  2  1  4  2  3  4  3  3  2     3  3  1  3  2  2  3  3  4|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                      2   |             
      Serosa, Inflammation, Suppurative    |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|             
                                           | 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  A  +  +     +   |             
      Circumanal Gland, Hyperplasia,       |                                                                          |             
          Glandular                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +     A     +  +  +  +  +  +  +  +     +   |             
      Angiectasis                          |    1                                                                     |             
      Basophilic Focus                     |                                                                          |             
      Developmental Malformation           |                            X                          X                  |             
      Fatty Change                         | 2  1        2           2                          2                     |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                             3            |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Coagulative                |       1                                   1     1  2                     |             
      Bile Duct, Hyperplasia               |                2  2        1  3                             4            |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Hepatocyte, Hyperplasia              | 2                                                                        |             
      Periductular, Fibrosis               |                               2                                          |             
      Periductular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                            2                                             |             
      Periductular, Inflammation, Chronic  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +                          +     +                 +  +        +|             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Inflammation, Fibrinopurulent   |                                           3                              |             
      Fat, Necrosis, Coagulative           |    3     3                          3     2                    4        3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  +  +  +     +   |             
      Atrophy                              |                2                                            2            |             
      Ectopic Tissue                       |                                                                          |             
      Hyperplasia                          |             3                                3     2                     |             
      Inflammation, Necrotizing            |                                           3                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +        +  A     +     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +        +  A     +     +  +  +  +  +  +  +  +     +   |             
      Cyst Epithelial Inclusion            |                                                 3                        |             
      Hyperplasia, Squamous                |             2                                   1  3     2     3         |             
      Inflammation, Chronic                |             4                                      2     4     1         |             
      Ulcer                                |                                           2  4        4     4        3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +        +  A     +     +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|             
                                           | 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                 1                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Cardiomyopathy                       | 1  2     2  2     2        2  2     2     2  2  2  2  2  1     2         |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Cytoplasmic Alteration               |                                                       2                  |             
      Hemorrhage                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Cyst                                 |                4                                                         |             
      Hyperplasia                          |                                                 2                        |             
      Necrosis, Liquifactive               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +        +  A     A     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +        +  +     +     +  +  +  +  M  +  +  +     M   |             
      Hyperplasia                          |    2  1     3                                   3  2     2  3  2         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  M  +     +   |             
      Inflammation, Suppurative            |                                                                          |             
      Pars Distalis, Cyst                  |                                                 3                        |             
      Pars Distalis, Cyst Multilocular     |                                                                          |             
      Pars Distalis, Hemorrhage, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  A  +  +     +   |             
      C-Cell, Hyperplasia                  |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +        +  +     M     +  +  +  +  +  +  +  +     +   |             
      Hyperplasia                          |                                                                4         |             
      Inflammation, Chronic                |                   2                                                      |             
      Inflammation, Suppurative            |       4                                                        4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|             
                                           | 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     |                                                                      3   |             
      Duct, Inflammation, Suppurative      |                2                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  A  +  +     +   |             
      Inflammation, Suppurative            |                                                    3                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              |                         4                 4                              |             
      Polyarteritis                        |                                                                          |             
      Interstitial Cell, Hyperplasia       |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Hypercellularity                     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  M  +  +     +   |             
      Hyperplasia, Lymphoid                | 3              3  3                                                      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Hemorrhage                           |                                           3                              |             
      Hyperplasia, Lymphoid                |                3                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Congestion                           | 2           3                                                            |             
      Developmental Malformation           |                                     X                                    |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |                                           3                              |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Perivascular, Fibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +        +  +     +     +  +  +  M  +  +  +  +     +   |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +        +  M     +     +  +  +  +  +  A  +  +     +   |             
      Galactocele                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Alopecia                             |                                           3                              |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 7| 5| 5| 4| 4| 4| 5| 4| 4| 4| 6| 5| 7| 3| 6| 6| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 7| 8| 2| 9| 9| 5| 5| 7| 4| 5| 5| 5| 9| 6| 1| 4| 4| 5| 2| 2| 5| 9| 5|             
                                           | 0| 1| 3| 4| 9| 9| 9| 8| 9| 2| 8| 9| 5| 8| 4| 7| 8| 0| 5| 7| 1| 9| 8| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    150MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Metaplasia, Osseous                  |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Hemorrhage                           |                                                                          |             
      Meninges, Congestion                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |             
      Alveolus, Edema                      |                               3                                          |             
      Alveolus, Hemorrhage                 |                               3                                          |             
      Alveolus, Inflammation, Suppurative  |       2                             2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Lumen, Fungus                        |                   3        4                    3                        |             
      Lumen, Inflammation, Suppurative     |                                           2     2                        |             
      Mucosa, Inflammation, Suppurative    |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  +  +  +     +   |             
      Inflammation, Suppurative            |                            2  2                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Perforation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Bilateral, Lens, Cataract            |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 4  4  2  1  4  3  2  1  2  2  2  2     2  4  4  4  4  4  3  4  4  1  4  2|             
      Renal Tubule, Hyperplasia            |                                                 1  1                 2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +        +  +     +     +  +  +  +  +  A  +  +     +   |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 6| 4| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6|                                            |            |
                                           | 8| 7| 9| 4| 1| 8| 8| 3| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +        +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +        +  +  +                                             |  44        |
      Circumanal Gland, Hyperplasia,       |                                                                          |            |
          Glandular                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +        A  +  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +        A  +  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +        +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +        +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +        +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +        +  +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +        A  +  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | A  +  +  +  +        +  +  +                                             |  49        |
      Angiectasis                          |    1  1                                                                  |      3  1.0|
      Basophilic Focus                     |       1                                                                  |      1  1.0|
      Developmental Malformation           |                         X                                                |      5     |
      Fatty Change                         |                                                                          |      7  1.6|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |    4                                                                     |      1  4.0|
      Necrosis, Coagulative                |                                                                          |      4  1.3|
      Bile Duct, Hyperplasia               |          2           3                                                   |     17  2.1|
      Centrilobular, Necrosis, Coagulative |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Periductular, Fibrosis               |                      3                                                   |      6  2.0|
      Periductular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Periductular, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |  16        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Inflammation, Fibrinopurulent   |    4                                                                     |      3  3.7|
      Fat, Necrosis, Coagulative           |                                                                          |     11  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +        +  +  +                                             |  47        |
      Atrophy                              |                                                                          |      4  2.3|
      Ectopic Tissue                       |                                                                          |      1     |
      Hyperplasia                          |    2        3                                                            |      5  2.6|
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +        +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | A  +  +  +  +        +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +  +  +  +        +  +  +                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 6| 4| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6|                                            |            |
                                           | 8| 7| 9| 4| 1| 8| 8| 3| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cyst Epithelial Inclusion            |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |     11  2.2|
      Inflammation, Chronic                |                                                                          |      8  2.6|
      Ulcer                                |    4        4              3                                             |     14  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +  +  +        +  +  +                                             |  47        |
      Erosion                              |          2           4                                                   |      3  2.3|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +        +  +  +                                             |  50        |
      Cardiomyopathy                       |             2              2                                             |     33  2.0|
      Atrium, Thrombosis                   |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | A  +  +  +  +        +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | A  +  +  +  +        +  +  +                                             |  49        |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |    2                                                                     |      6  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | A  +  +  +  +        +  +  +                                             |  49        |
      Cyst                                 |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Necrosis, Liquifactive               |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +  +  +  +        +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | A  M  M  +  I        +  +  +                                             |  41        |
      Hyperplasia                          |                                                                          |     15  2.1|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | A  +  +  +  +        +  +  +                                             |  48        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |                         3                                                |      4  3.0|
      Pars Distalis, Cyst Multilocular     |                                                                          |      1  2.0|
      Pars Distalis, Hemorrhage, Chronic   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A  +  +  +  +        +  +  +                                             |  48        |
      C-Cell, Hyperplasia                  |             2                                                            |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 6| 4| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6|                                            |            |
                                           | 8| 7| 9| 4| 1| 8| 8| 3| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
      Hemorrhage                           |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +        +  +  +                                             |  50        |
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +        +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |             3           2                                                |      9  3.4|
      Duct, Dilatation                     |                                                                          |      2  3.0|
      Duct, Inflammation, Suppurative      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | A  +  +  +  +        +  +  +                                             |  48        |
      Inflammation, Suppurative            |                                                                          |      8  3.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +        +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | A  +  +  +  +        +  +  +                                             |  52        |
      Atrophy                              |                                                                          |      3  4.0|
      Polyarteritis                        |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +        +  +  +                                             |  49        |
      Hypercellularity                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | A  +  +  +  +        +  +  +                                             |  49        |
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | A  +  +  +  +        +  +  +                                             |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      4  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  +  +        +  +  +                                             |  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +        +  +  +                                             |  48        |
      Congestion                           |                                                                          |      3  2.7|
      Developmental Malformation           |                                                                          |      2     |
      Fibrosis                             |    2                                                                     |      1  2.0|
      Hyperplasia, Lymphoid                |             2                                                            |      3  2.3|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 6| 4| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6|                                            |            |
                                           | 8| 7| 9| 4| 1| 8| 8| 3| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Perivascular, Fibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +        +  +  +                                             |  47        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +        +  +  +                                             |  46        |
      Galactocele                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +        +  +  +                                             |  50        |
      Alopecia                             |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +        +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Metaplasia, Osseous                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +        +  +  +                                             |  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Meninges, Congestion                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +        +  +  +                                             |  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Alveolus, Edema                      |                                                                          |      2  3.0|
      Alveolus, Hemorrhage                 |                            2                                             |      2  2.5|
      Alveolus, Inflammation, Suppurative  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +        +  +  +                                             |  50        |
      Lumen, Fungus                        |                         3                                                |      5  3.2|
      Lumen, Inflammation, Suppurative     |                         3                                                |      8  2.3|
      Mucosa, Inflammation, Suppurative    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +        +  +  +                                             |  50        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 6| 4| 4| 6| 7| 4|                                            |            |
                             DAY ON TEST   | 8| 7| 2| 8| 8| 5| 5| 2| 2| 6|                                            |            |
                                           | 8| 7| 9| 4| 1| 8| 8| 3| 9| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    150MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
      Pinna, Perforation                   |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |       +     +                                                            |   2        |
      Bilateral, Lens, Cataract            |             3                                                            |      1  3.0|
      Lens, Cataract                       |       4                                                                  |      1  4.0|
      Retina, Degeneration                 |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | A  +  +  +  +  +  +  +  +  +                                             |  58        |
      Nephropathy                          |    4  3  2  4  2  2  1  4  2                                             |     57  2.8|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +        +  +  +                                             |  48        |
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|             
                                           | 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Submucosa, Inflammation, Suppurative |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                2                                                         |             
      Developmental Malformation           |                      X  X                                                |             
      Inflammation, Necrotizing            |                            4                                             |             
      Necrosis, Coagulative                |                                                                          |             
      Bile Duct, Hyperplasia               | 2                             1           3     3              2         |             
      Centrilobular, Necrosis, Coagulative |    4     1           3     3                                   2         |             
      Hepatocyte, Hyperplasia              |                                  2                                       |             
      Periductular, Fibrosis               |                                                 3              2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +  +                          +     +           M        +|             
      Fat, Inflammation, Chronic           |                                                    3                     |             
      Fat, Inflammation, Chronic Active    |                4  4                                                      |             
      Fat, Necrosis, Coagulative           |          2                                   2                          3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                   2                                         3            |             
      Inflammation, Chronic                |    4                                                                     |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        M  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                | 3              2  3                 3  1     1                    1  1   |             
      Inflammation, Chronic                | 1              2  4                 2  1     1                    1  1   |             
      Ulcer                                |          3  4        2                       4     3        3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Erosion                              |                   2                                                      |             
      Inflammation, Chronic                |                                                 1                        |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|             
                                           | 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +                                      +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Cardiomyopathy                       | 2  2  2  2     2  2  2  2  2  2  2  2     2  2     2        2  2  2      |             
      Necrosis, Zenkers                    |             2                                                            |             
      Atrioventricular Valve, Thrombosis   |                                                 3                        |             
      Atrium, Thrombosis                   |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Vacuolization Cytoplasmic            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hyperplasia                          |                                        2                    3        3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hyperplasia                          | 3        2  2  2  2     3  2  2     3  2     2              2  2     2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +   |             
      Pars Distalis, Cyst                  |                                              3  2        2     4         |             
      Pars Distalis, Cyst Multilocular     |                                  X                                       |             
      Pars Distalis, Hemorrhage, Acute     |                                                                   4      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      C-Cell, Hyperplasia                  |                                                    1                 2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        M  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hyperplasia                          |    2                                3        3                 3         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       2                             4                          4  2      |             
      Duct, Dilatation                     |                                                                          |             
      Duct, Inflammation, Suppurative      |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        M  +  +  +   |             
      Hyperplasia                          |                                              1                           |             
      Inflammation, Suppurative            |                      2  3     2                    2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        M  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +|             
      Atrophy                              |                                                                      4  4|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|             
                                           | 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hyperplasia, Neutrophil              |    3                                                                     |             
      Myelofibrosis                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Lumbar, Congestion                   |                                                    3                     |             
      Mediastinal, Congestion              |                                                    2                     |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                 4                        |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        M  M  +  +   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Suppurative            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Congestion                           |                                                                      3   |             
      Inflammation, Suppurative            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +        M  +  +  +   |             
      Congestion, Diffuse                  |                                                                          |             
      Congestion                           |                               3                 3                        |             
      Developmental Malformation           | X                                                                        |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Chronic                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Inflammation, Suppurative            |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Galactocele                          |                                                    3                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Alopecia                             | 3                                                                    3   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                      2   |             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Developmental   |                                                                          |             
          Malformation                     |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 6| 6| 4| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 1| 8| 3| 9| 0| 3| 6| 7| 9| 0| 2| 1| 7| 0| 2| 9| 0| 3| 5| 5| 2| 2| 9| 0| 5|             
                                           | 5| 4| 0| 0| 8| 0| 5| 4| 5| 9| 9| 9| 5| 1| 9| 7| 5| 4| 8| 8| 3| 5| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        M  +  +  +   |             
      Hypothalamus, Hemorrhage, Acute      |                                                                   3      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                 +                                      +     +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                 +                                      +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Alveolar Epithelium, Hyperplasia     |       2                                                        2         |             
      Alveolus, Hemorrhage                 |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        M  +  +  +   |             
      Autolysis                            |                                                                          |             
      Fungus                               |                                  4                                       |             
      Inflammation, Chronic                |                                                                          |             
      Lumen, Fungus                        |       3                                3  3                              |             
      Lumen, Inflammation, Suppurative     |       3                                2  3  2                           |             
      Mucosa, Inflammation, Suppurative    | 3                                                                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2  2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
      Acanthosis                           |                               2                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Nephropathy                          | 4  3  4     4  4  4  4  4  4  4  3  4  4  2  4  2  4  1  2     4  2  3  1|             
      Cortex, Infarct                      |                                           3                              |             
      Renal Tubule, Hyperplasia, Cystic    | 1                 2                                                      |             
      Renal Tubule, Hyperplasia, Oncocytic |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +        M  +  +  +   |             
      Submucosa, Infiltration Cellular,    |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|             
                             DAY ON TEST   | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|             
                                           | 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A     +  +  A  +  +  +  +  +  +  +  +  +     A  +  +  +  A        +  +|             
      Submucosa, Inflammation, Suppurative |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A     +  +  +  +  +  +  +  +  +  A  +  +     A  +  +  +  A        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M     +  +  +  +  +  +  +  +  +  +  +  +     A  +  +  +  A        +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Necrosis, Coagulative                |                                                          1               |             
      Bile Duct, Hyperplasia               | 2                       2  3        2  2  2     2                        |             
      Centrilobular, Necrosis, Coagulative |    2                                            3     1                  |             
      Hepatocyte, Hyperplasia              |                               1                          1               |             
      Periductular, Fibrosis               | 3        2                 2        2     2                 2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +           +        +                     |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis, Coagulative           |                               3           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Atrophy                              | 2                                                                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                          3               |             
      Inflammation, Chronic                |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                                                             4            |             
      Hyperplasia, Squamous                | 3              1        1     1                 1                        |             
      Inflammation, Chronic                | 3        3     1        1     1                 1  3                     |             
      Ulcer                                |    3     4  1  4     3        2           3        2     3  3        3  2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Erosion                              | 2                                               2                        |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|             
                             DAY ON TEST   | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|             
                                           | 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Cardiomyopathy                       | 2  2           2  2  2  2     2     2  2  2     3     2                  |             
      Necrosis, Zenkers                    |                                                                          |             
      Atrioventricular Valve, Thrombosis   |                                                                          |             
      Atrium, Thrombosis                   |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Vacuolization Cytoplasmic            |          3                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Hyperplasia                          |             2        2                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +        +  +|             
      Hyperplasia                          | 2        2  2  2     2        3     2     3     3        2  2        2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +        +  M|             
      Pars Distalis, Cyst                  |    2              2                                                      |             
      Pars Distalis, Cyst Multilocular     |                                                                          |             
      Pars Distalis, Hemorrhage, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
      C-Cell, Hyperplasia                  |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Hyperplasia                          |                                                       3                 4|             
      Inflammation, Chronic                |                                                 2                        |             
      Inflammation, Suppurative            |    3                                                  3                 4|             
      Duct, Dilatation                     |                                                             3            |             
      Duct, Inflammation, Suppurative      |                         2                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            | 4  2        3                    4  3           3        3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Atrophy                              |                         2                                                |             
      Interstitial Cell, Hyperplasia       |             3                                      3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|             
                             DAY ON TEST   | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|             
                                           | 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Lumbar, Congestion                   |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                       2                  |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Hyperplasia, Plasma Cell             |                   3                                   3                  |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A        +  M|             
      Congestion, Diffuse                  | 4                                                                        |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              | 3                                               2                        |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  I  +  +  +  +  +  +  +     +  +  +  M  +        +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                     3                                    |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Developmental   |                                                                          |             
          Malformation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 4| 7| 6| 6| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 5| 6| 6| 6| 5| 4| 4| 5| 6|             
                             DAY ON TEST   | 9| 2| 5| 1| 9| 9| 3| 6| 1| 3| 3| 0| 0| 2| 7| 5| 5| 6| 9| 6| 2| 5| 5| 9| 9|             
                                           | 6| 0| 9| 6| 7| 4| 0| 6| 3| 4| 0| 3| 9| 9| 9| 9| 4| 2| 4| 2| 2| 8| 8| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Hypothalamus, Hemorrhage, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |          +  M  +                 +                                       |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +  +  +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Alveolus, Hemorrhage                 |                   2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Autolysis                            |                                                 4                        |             
      Fungus                               |                                                 X                        |             
      Inflammation, Chronic                |                            2                                             |             
      Lumen, Fungus                        |                                  4                 4                     |             
      Lumen, Inflammation, Suppurative     |                                                    4  2                  |             
      Mucosa, Inflammation, Suppurative    |                         2                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +|             
      Inflammation, Suppurative            |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Nephropathy                          | 3  3  1  4  3  3  3  4  3  1  4  1  4  3  3  2  4  2  2  4  3  2  1  4   |             
      Cortex, Infarct                      |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M|             
      Submucosa, Infiltration Cellular,    |                                                                          |             
           Lymphocyte                      |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 4| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5|                                            |            |
                                           | 7| 0| 9| 1| 9| 3| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     A     +  +  A  +                                                |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     A     +  +  A  +                                                |  41        |
      Submucosa, Inflammation, Suppurative |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     A     +  +  A  +                                                |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     A     +  +  A  +                                                |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     A     +  +  A  +                                                |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     A     +  +  A  +                                                |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     A     +  +  A  +                                                |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     A     +  +  A  +                                                |  43        |
      Hemorrhage                           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +  +                                             |  53        |
      Angiectasis                          |                   1                                                      |      1  1.0|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Developmental Malformation           |                                                                          |      2     |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                   2                                                      |     13  2.2|
      Centrilobular, Necrosis, Coagulative |                                                                          |      8  2.4|
      Hepatocyte, Hyperplasia              |                                                                          |      3  1.3|
      Periductular, Fibrosis               |                      2                                                   |      9  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +                                                   |  11        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      2  4.0|
      Fat, Necrosis, Coagulative           |                      4                                                   |      6  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     A     +  +  +  +                                                |  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Hemorrhage                           |                      4                                                   |      1  4.0|
      Hyperplasia                          |                      3                                                   |      4  2.8|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Polyarteritis                        |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +  +                                                |  50        |
      Hemorrhage                           |                4                                                         |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Hyperplasia, Squamous                |                1                                                         |     14  1.6|
      Inflammation, Chronic                |                                                                          |     15  1.7|
      Ulcer                                |    2     4                                                               |     20  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 4| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5|                                            |            |
                                           | 7| 0| 9| 1| 9| 3| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +  +                                                |  50        |
      Erosion                              |    2                                                                     |      4  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Ulcer                                |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +  +                                                |  50        |
      Cardiomyopathy                       | 2  2              2  2                                                   |     34  2.0|
      Necrosis, Zenkers                    |                                                                          |      1  2.0|
      Atrioventricular Valve, Thrombosis   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +     +  +  +  +                                                |  49        |
      Vacuolization Cytoplasmic            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +     +  +  +  +                                                |  49        |
      Hyperplasia                          |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     A     +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     M     +  +  +  +                                                |  48        |
      Hyperplasia                          |                                                                          |     26  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +  +  +                                                |  48        |
      Pars Distalis, Cyst                  |                   3                                                      |      7  2.6|
      Pars Distalis, Cyst Multilocular     |                                                                          |      1     |
      Pars Distalis, Hemorrhage, Acute     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  +  +                                                |  49        |
      C-Cell, Hyperplasia                  |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +     +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +     +  +  +  +                                                |  48        |
      Hyperplasia                          |                                                                          |      6  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      7  3.1|
      Duct, Dilatation                     | 4                                                                        |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 4| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5|                                            |            |
                                           | 7| 0| 9| 1| 9| 3| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Inflammation, Suppurative      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +     +  +  +  +                                                |  46        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                   2                                                      |     12  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +     +  +  +  +                                                |  46        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +     +  +  +  +                                                |  51        |
      Atrophy                              |    4                                                                     |      4  3.5|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +  +                                                |  50        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +  +                                                |  50        |
      Lumbar, Congestion                   |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +     +  +  +  +                                                |  44        |
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +                                                |  45        |
      Congestion, Diffuse                  |                                                                          |      1  4.0|
      Congestion                           |                                                                          |      2  3.0|
      Developmental Malformation           |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Macrophage              |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +  +  +                                                |  47        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 4| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5|                                            |            |
                                           | 7| 0| 9| 1| 9| 3| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +     +  +  +  M                                                |  47        |
      Galactocele                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +  +  +                                                |  48        |
      Alopecia                             |                                                                          |      2  3.0|
      Cyst Epithelial Inclusion            |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
      Subcutaneous Tissue, Developmental   |                                                                          |            |
          Malformation                     |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +  +                                                |  46        |
      Hypothalamus, Hemorrhage, Acute      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +  +                                                |  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Alveolus, Hemorrhage                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +  +  +                                                |  48        |
      Autolysis                            |                                                                          |      1  4.0|
      Fungus                               |                                                                          |      2  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Lumen, Fungus                        |                      3                                                   |      6  3.3|
      Lumen, Inflammation, Suppurative     |                   2  2  3                                                |      9  2.6|
      Mucosa, Inflammation, Suppurative    |                                                                          |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +  +                                                |  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Acanthosis                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 4| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 7| 5| 8| 5| 3| 2| 7| 5| 5|                                            |            |
                                           | 7| 0| 9| 1| 9| 3| 9| 8| 4| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Nephropathy                          | 2  3  2  3  1  4  3  3  2  1                                             |     57  2.9|
      Cortex, Infarct                      |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      2  1.5|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +  +                                                |  44        |
      Submucosa, Infiltration Cellular,    |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|             
                             DAY ON TEST   | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|             
                                           | 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  A  A  +  A|             
      Inflammation, Suppurative            |                                                                          |             
      Submucosa, Edema                     |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  A  A  A  A  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  A  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     | 1                                         2                              |             
      Developmental Malformation           |                X                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |                      2                                                   |             
      Regeneration                         |                                     3                                    |             
      Artery, Dilatation                   |                                                                          |             
      Bile Duct, Cyst                      |                      X                                                   |             
      Bile Duct, Hyperplasia               |                      2     2                    3        2           2   |             
      Centrilobular, Inflammation,         |                                                                          |             
          Necrotizing                      |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                         3  2                    2                        |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Periductular, Fibrosis               |                                                             1        2   |             
      Periductular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                   +                                    |             
      Fat, Necrosis, Coagulative           | 2                                   1                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
      Atrophy                              |    4                                                                     |             
      Hyperplasia                          |                                                             3            |             
      Inflammation, Chronic                |                4                                                         |             
      Inflammation, Suppurative            |          2                                                               |             
      Necrosis, Liquifactive               |                                                                          |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |    1              2                                2  3     1        1   |             
      Inflammation, Chronic                |    1              1                                1  1                  |             
      Ulcer                                |       2        2  2           2                                   2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|             
                             DAY ON TEST   | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|             
                                           | 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                         1                                                |             
      Inflammation, Chronic                |                         2                                                |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2  2  3  3  2     2  2           3     2  2  1  2  2     3  2  2|             
      Atrioventricular Valve, Fibrosis     |                                                                          |             
      Atrium, Inflammation, Suppurative    |                                                                          |             
      Atrium, Thrombosis                   |       2                             3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Suppurative            |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  M  M|             
      Hyperplasia                          |    2           2              2        2        2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +|             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Cyst Multilocular     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M|             
      C-Cell, Hyperplasia                  |                                        2                                 |             
      Follicle, Cyst                       |                                           X           2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
      Inflammation, Chronic                |                            2              2                              |             
      Inflammation, Suppurative            |                                                    4                    3|             
      Duct, Dilatation                     |          2                                                               |             
      Duct, Inflammation, Suppurative      |                                                                      3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |             2                                   4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|             
                             DAY ON TEST   | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|             
                                           | 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitium, Hemorrhage, Acute      |                2                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              | 4                                                                        |             
      Interstitial Cell, Hyperplasia       |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                      +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Mediastinal, Congestion              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  M|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |          3                                3                              |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
      Fibrosis                             |                                     2                                    |             
      Necrosis, Liquifactive               |                                                 4                        |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Subcapsular, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                                                                3         |             
      Capsule, Inflammation, Suppurative   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Alopecia                             |    2                                                                     |             
      Cyst Epithelial Inclusion            |                                                                      4   |             
      Inflammation, Chronic                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
      Thalamus, Necrosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                        +           +                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +        +           +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 5| 5| 4| 5| 4| 6| 4| 6| 6| 4| 0| 6| 6| 6| 6| 7| 0| 4| 5| 6|             
                             DAY ON TEST   | 3| 8| 2| 6| 1| 6| 2| 5| 5| 5| 7| 5| 9| 6| 5| 4| 0| 7| 9| 6| 2| 4| 4| 7| 0|             
                                           | 0| 8| 7| 3| 2| 9| 8| 9| 2| 8| 3| 9| 0| 8| 9| 5| 5| 2| 6| 8| 0| 4| 4| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |             
      Alveolus, Congestion                 |                                                                          |             
      Alveolus, Edema                      |                                                                2         |             
      Alveolus, Foreign Body               |                                              1                           |             
      Alveolus, Hemorrhage                 |                                                                3         |             
      Alveolus, Inflammation, Suppurative  |                                                                3         |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Lumen, Foreign Body                  |                                              2                 2         |             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Suppurative     |          3                                                              3|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +|             
      Inflammation, Suppurative            |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Lens, Cataract                       |                               4                                          |             
      Retina, Degeneration                 |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    4                     |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 4  3  3  2  3  4  3  2  3  2  4  2  1  3  2     1  4  3  4  4        3  3|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Infarct                      |                                     3                                    |             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                 2                        |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia            |             1                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|             
                                           | 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  +  +  +  +  +  +  +  +  +  A  +  A  A  A  +  A  A  A  +  +  A  A  +|             
      Inflammation, Suppurative            |                                                                          |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  +  +  +  +  +  +  +  +  A  +  A  A  A  +  A  A  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |          2  2                                                            |             
      Developmental Malformation           |                         X                          X  X                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |                            2                          3  3               |             
      Regeneration                         |                                                                          |             
      Artery, Dilatation                   |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                2        2                    2  1                        |             
      Centrilobular, Inflammation,         |                                                                          |             
          Necrotizing                      |             2                                                            |             
      Centrilobular, Necrosis, Coagulative |    3                                                                     |             
      Hepatocyte, Hyperplasia              |                         1                                                |             
      Periductular, Fibrosis               |                                                 1                        |             
      Periductular, Inflammation, Chronic  |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +  +           +  +                     |             
      Fat, Necrosis, Coagulative           |                      2              3           3  3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  A  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 3                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Liquifactive               |                                                                          |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
      Hyperkeratosis                       |                                                 2                        |             
      Hyperplasia, Squamous                |                                        2                    1            |             
      Inflammation, Chronic                |                                        2     1                           |             
      Ulcer                                | 2                 3     3        2              1     3     3  2  3     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|             
                                           | 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                  2           2                           |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                              3                           |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3     3  2  2     2     2  2  2     2  1     1  2     2  2     2  2  2|             
      Atrioventricular Valve, Fibrosis     |                                        3                                 |             
      Atrium, Inflammation, Suppurative    |                                                    3                     |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2           2     2     2  2  2           2  2              2  2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst Multilocular     |                                                                2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                      3   |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       4        3                                   4                    4|             
      Duct, Dilatation                     |                      4                                                   |             
      Duct, Inflammation, Suppurative      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|             
                                           | 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitium, Hemorrhage, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         4|             
      Interstitial Cell, Hyperplasia       |          3     2           3                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |       2                          3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Necrosis, Liquifactive               |                                                                2         |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Subcapsular, Hemorrhage              |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Hemorrhage                           |                                                                          |             
      Capsule, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Necrosis                   |                                                                         3|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 4| 4| 4| 4| 6| 4| 5| 6| 6| 5| 3| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 7| 5| 8| 5| 5| 5| 8| 5| 6| 5| 0| 9| 8| 8| 6| 3| 3| 1| 1| 5| 9| 4| 7| 0| 5|             
                                           | 7| 4| 1| 8| 8| 8| 3| 8| 2| 9| 1| 0| 7| 4| 5| 7| 0| 0| 6| 9| 4| 0| 3| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                          2               |             
      Alveolus, Congestion                 |                                                                      3   |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Foreign Body               |                                                                          |             
      Alveolus, Hemorrhage                 |                                                                          |             
      Alveolus, Inflammation, Suppurative  |                                     1                                    |             
      Bronchiole, Inflammation, Suppurative|                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                          2               |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Fungus                        |                   4              4        4                              |             
      Lumen, Inflammation, Suppurative     |                                  3        2                    3         |             
      Mucosa, Inflammation, Suppurative    |                   2                                                      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                    3                     |             
      Nephropathy                          | 3  4  4  2  2  1  4  2  4  1  4  4  4  4  1  4  4  4  4  4  4  4  4  4  3|             
      Cortex, Cyst                         |                                                       4                  |             
      Cortex, Infarct                      |                                                                          |             
      Pelvis, Inflammation, Chronic        |                                                                      3   |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |       2                                                                  |             
      Renal Tubule, Hyperplasia            |                   2                                            1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 6| 7| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9|                                            |            |
                                           | 8| 3| 9| 2| 1| 0| 7| 6| 5| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  A  +  A  A  +  A                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  A  +  A  A  +  A                                             |  34        |
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Submucosa, Edema                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  A  +  A  A  +  A                                             |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  A  +  A  A  +  A                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  A  A  +  A                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  A  A  +  A                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  A  +  A  A  +  A                                             |  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  A  A  +  A                                             |  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Clear Cell Focus                     |                                                                          |      4  1.8|
      Developmental Malformation           |                X                                                         |      5     |
      Inflammation, Chronic                |             2                                                            |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      4  2.5|
      Regeneration                         |                                                                          |      1  3.0|
      Artery, Dilatation                   |    4                                                                     |      1  4.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    2                                                                     |     10  2.0|
      Centrilobular, Inflammation,         |                                                                          |            |
          Necrotizing                      |                                                                          |      1  2.0|
      Centrilobular, Necrosis, Coagulative |                            3                                             |      5  2.6|
      Hepatocyte, Hyperplasia              |                                                                          |      1  1.0|
      Periductular, Fibrosis               |                2                                                         |      4  1.5|
      Periductular, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Fat, Necrosis, Coagulative           |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  A  A  +  A                                             |  48        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia                          |          2              2                                                |      4  2.5|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Necrosis, Liquifactive               |             3                                                            |      1  3.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  M  M  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  A  +  +  +  +  A  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  A  +  +  +                                             |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 6| 7| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9|                                            |            |
                                           | 8| 3| 9| 2| 1| 0| 7| 6| 5| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |             3  4        2                                                |     11  2.0|
      Inflammation, Chronic                |             2  1                                                         |      8  1.3|
      Ulcer                                |          3                                                               |     16  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  A  +  +  +                                             |  53        |
      Erosion                              |                         2                                                |      4  1.8|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    3     2  2           2  2                                             |     40  2.1|
      Atrioventricular Valve, Fibrosis     |                                                                          |      1  3.0|
      Atrium, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytoplasmic Alteration               |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |             2                                                            |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  A  +  A                                             |  52        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  +                                             |  51        |
      Hyperplasia                          |             2           2                                                |     19  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +                                             |  56        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Cyst Multilocular     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  M  M  +  +                                             |  50        |
      C-Cell, Hyperplasia                  |                            3                                             |      3  2.7|
      Follicle, Cyst                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 6| 7| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9|                                            |            |
                                           | 8| 3| 9| 2| 1| 0| 7| 6| 5| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  M  +  +  +  +  +  +  +  M                                             |  57        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |             4                                                            |      2  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |             4                                                            |      7  3.7|
      Duct, Dilatation                     |                                                                          |      2  3.0|
      Duct, Inflammation, Suppurative      |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            | 4                 4                                                      |      5  3.2|
      Interstitium, Hemorrhage, Acute      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  M  +  +  +  +  +  +  +  M                                             |  56        |
      Atrophy                              |                         4                                                |      3  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +                                             |  58        |
      Mediastinal, Congestion              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +                                             |  52        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +                                             |  55        |
      Fibrosis                             |                                                                          |      1  2.0|
      Necrosis, Liquifactive               |                                                                          |      2  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Subcapsular, Hemorrhage              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Capsule, Inflammation, Suppurative   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  M  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 6| 7| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9|                                            |            |
                                           | 8| 3| 9| 2| 1| 0| 7| 6| 5| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Alopecia                             |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  A  +  +  +                                             |  57        |
      Thalamus, Necrosis                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar Epithelium, Hyperplasia     |                2                                                         |      3  1.7|
      Alveolus, Congestion                 |                                                                          |      1  3.0|
      Alveolus, Edema                      |                                                                          |      1  2.0|
      Alveolus, Foreign Body               |                                                                          |      1  1.0|
      Alveolus, Hemorrhage                 |                                                                          |      1  3.0|
      Alveolus, Inflammation, Suppurative  |                                                                          |      2  2.0|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fungus                               |                                                                          |      1  2.0|
      Lumen, Foreign Body                  |                                                                          |      2  2.0|
      Lumen, Fungus                        |                            4                                             |      4  4.0|
      Lumen, Inflammation, Suppurative     | 4           2        3                                                   |      8  2.9|
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 6| 7| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 9| 5| 7| 1| 4| 0| 0| 2| 9|                                            |            |
                                           | 8| 3| 9| 2| 1| 0| 7| 6| 5| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy                          | 3  2  1  4  4  4  3  4  4  3                                             |     57  3.1|
      Cortex, Cyst                         |                                                                          |      1  4.0|
      Cortex, Infarct                      |                                                                          |      1  3.0|
      Pelvis, Inflammation, Chronic        |                                                                          |      1  3.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  A  A  +  A                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|              |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7|              |            |
                                           | 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    39 KILL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                    A                     |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Fatty Change                         | 1  1  1     1     1        1           1     1        1  1               |     10  1.0|
      Necrosis, Coagulative                |                                                       1                  |      1  1.0|
      Bile Duct, Hyperplasia               |             1                                            1               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
      Granuloma                            |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Atrophy                              |                               2        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Cardiomyopathy                       | 1  2     1  2  1  1  2  2  2  1  1  1  2     1  2     1  2               |     17  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  M  +  +  +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|              |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7|              |            |
                                           | 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    39 KILL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +              +                     |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Inflammation, Suppurative            |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Degeneration                         |                                           3                              |      1  3.0|
      Interstitial Cell, Hyperplasia       | 1     1        1  1  1  1  1        1           1     1  1               |     11  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           |                                                    4                     |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|              |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7|              |            |
                                           | 5| 5| 6| 4| 6| 5| 6| 4| 5| 6| 4| 4| 5| 4| 4| 5| 6| 7| 4| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    0 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    39 KILL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           |                                                    4                     |      1  4.0|
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1               |     19  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                                           | 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     39 KILL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           |                                  4                                       |      1  4.0|
      Developmental Malformation           |                                                 X                        |      1     |
      Bile Duct, Hyperplasia               | 1        1                             1  1     1     1                  |      6  1.0|
      Kupffer Cell, Hyperplasia            |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Inflammation, Chronic                |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hyperplasia, Squamous                |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Cardiomyopathy                       | 2  1  1        1  1  1     1  2           2  1  1     1  1               |     13  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                                           | 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     39 KILL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Inflammation, Chronic Active         |                         2  2              2        2                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Interstitial Cell, Hyperplasia       |          1  1           1  1  1     1           1  1  1                  |      9  1.0|
      Seminiferous Tubule, Degeneration    |    3                                3        4                           |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                  +              +                        |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +                       +                                       |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                  +                                       |   1        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                  2                                       |      1  2.0|
      Submucosa, Congestion                |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 106                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                                           | 4| 6| 4| 6| 5| 4| 4| 4| 4| 6| 5| 6| 4| 4| 4| 6| 5| 4| 4| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    600MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     39 KILL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Nephropathy                          | 1     1  1  1  1  1  1  1  1  2     1  1  1  1  1  1  1  1               |     18  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
NTP Experiment-Test: 05091-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        3,4-DIHYDROCOUMARIN                                    Date: 04/25/97  
Route: GAVAGE                                                                                                     Time: 09:56:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 6| 1| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|              |            |
                             DAY ON TEST   | 9| 4| 5| 5| 8| 5| 6| 0| 2| 5| 2| 2| 2| 2| 8| 2| 2| 2| 5| 5|              |            |
                                           | 0| 0| 9| 5| 6| 4| 9| 1| 9| 5| 9| 9| 9| 9| 0| 9| 9| 9| 4| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      A     |
    600MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
     41 STOP                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  A  +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  A  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  A  +               |  13        |
      Polyarteritis                        | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +               |  16        |
      Polyarteritis                        | 2                                                                        |      1  2.0|