TDMS Study 05091-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics Cor 3,4-DIHYDROCOUMARIN DATE: 10/22/97
EXPERIMENT: 05091 TEST: 01 TIME: 13:41:26
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-45039 ROUTE: GAVAGE NTP C#: 55890B
PATHOLOGIST: R. DAHLGREN S. EUSTIS CAS: 119-84-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 002 VEHICLE CONTROL
INCLUDE 003 150MG/KG
INCLUDE 004 150MG/KG
INCLUDE 005 300MG/KG
INCLUDE 006 300MG/KG
INCLUDE 007 600MG/KG
INCLUDE 008 600MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics Cor 3,4-DIHYDROCOUMARIN DATE: 10/22/97
EXPERIMENT: 05091 TEST: 01 TIME: 13:41:26
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-45039 ROUTE: GAVAGE NTP C#: 55890B
PATHOLOGIST: R. DAHLGREN S. EUSTIS CAS: 119-84-6
3,4-DIHYDROCOUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 11 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 379 526 534 540 596 619 634 637 639 648 |
| 654 654 655 656 670 678 690 704 705 711 |
| 717 |
| CENSORED DEATHS |
| 45 458 458 458 458 459 459 459 459 459 |
| 541 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 150MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 36 CENSORED DEATHS 11 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 238 455 462 472 548 549 550 556 557 567 |
| 576 584 584 588 599 599 623 634 645 657 |
| 662 668 668 673 673 677 681 681 685 694 |
| 695 695 718 721 721 723 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 459 459 459 |
| 543 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 41 CENSORED DEATHS 11 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 494 522 527 554 592 596 603 605 613 615 |
| 633 634 634 654 662 662 665 666 670 674 |
| 675 678 679 681 684 690 691 694 694 695 |
| 697 697 701 708 709 709 709 716 720 723 |
| 725 |
| CENSORED DEATHS |
| 458 458 458 458 459 459 459 459 459 459 |
| 619 |
| |
==================================================================================
3,4-DIHYDROCOUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 600MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 46 CENSORED DEATHS 12 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 365 444 483 501 528 537 552 554 569 577 |
| 584 593 598 605 605 605 606 607 616 618 |
| 625 627 640 640 651 659 662 663 668 668 |
| 672 672 673 673 677 681 687 688 690 690 |
| 694 696 710 711 712 720 |
| CENSORED DEATHS |
| 44 45 458 458 458 458 458 459 459 459 |
| 459 459 |
| |
==================================================================================
3,4-DIHYDROCOUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.3 98.3 92.3 90.2 71.8 57.4 |
|CONTROL | |
| | |
|150MG/KG | 100.0 100.0 98.3 98.3 98.3 92.6 92.6 67.9 57.6 26.8 |
| | |
| | |
|300MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 84.0 65.6 16.4 |
| | |
| | |
|600MG/KG | 100.0 100.0 100.0 98.3 98.3 94.5 88.2 67.2 42.0 4.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 150MG/KG 300MG/KG 600MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 57.4% 26.8% 16.4% 4.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.004 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 630.8 613.3 657.3 623.8 |
|NATURAL DEATHS (C) | (17.5) (16.4) ( 9.0) (11.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 639.5 611.4 633.1 580.5 |
|(STANDARD ERROR) | (16.9) (14.6) (12.3) (17.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
3,4-DIHYDROCOUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 12 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 385 466 506 580 589 598 631 651 652 665 |
| 680 680 696 703 709 716 717 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 462 462 462 |
| 533 542 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 150MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 14 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 357 455 471 508 513 537 588 590 591 612 |
| 618 644 657 664 667 682 701 710 710 710 |
| 710 715 716 716 717 |
| CENSORED DEATHS |
| 6 49 73 300 461 461 461 461 462 462 |
| 462 462 462 542 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 10 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 387 538 552 580 595 611 618 622 624 631 |
| 633 667 672 678 680 689 692 695 696 700 |
| 710 717 717 724 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 462 462 462 462 |
| |
==================================================================================
3,4-DIHYDROCOUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 600MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 13 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 331 455 504 506 531 533 535 553 570 591 |
| 596 602 618 618 631 639 639 678 680 708 |
| 710 710 711 717 |
| CENSORED DEATHS |
| 41 90 461 461 461 462 462 462 462 462 |
| 462 521 638 |
| |
==================================================================================
3,4-DIHYDROCOUMARIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.3 96.3 94.3 88.0 79.6 65.0 |
|CONTROL | |
| | |
|150MG/KG | 100.0 100.0 100.0 98.2 98.2 94.3 87.9 81.3 70.3 46.1 |
| | |
| | |
|300MG/KG | 100.0 100.0 100.0 100.0 98.3 98.3 96.3 90.3 78.3 52.2 |
| | |
| | |
|600MG/KG | 100.0 100.0 100.0 98.3 98.3 96.6 86.1 75.6 65.0 49.8 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 150MG/KG 300MG/KG 600MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 65.0% 46.1% 52.2% 49.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.213 P=0.106 P=0.300 P=0.134 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 624.9 622.4 642.8 598.6 |
|NATURAL DEATHS (C) | (23.1) (19.9) (15.5) (19.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.5 599.9 649.9 609.6 |
|(STANDARD ERROR) | (14.4) (22.5) (13.6) (19.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
3,4-DIHYDROCOUMARIN
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
150MG/KG = 2
300MG/KG = 3
600MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 4 1 3
| 2 4 1 4 22 4 3 311
| 2 24 4 3311 3
| 2 4 4 123 31
90 + 44 31 1
| 4 22 33 1 1
| 44 4 33 11
| 2244 11
80 + 2 24 3 3 11
| 22 4
| 44 3 3
| 2 24 1 31
P 70 + 11
E | 2 2 1 1
R | 2 2 2 33 1 1
C | 44 22 33 11
E 60 + 444 2 2 11
N | 22 1 1
T | 4 4
| 223
S 50 + 44 33
U | 4 4 22
R | 33
V | 44
I 40 + 2 2
V |
A | 23 2
L | 44 33
30 + 22
| 44 2 2
| 44 33
|
20 + 33
| 44 3 3
|
| 4 4
10 +
| 44
| 4 4
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
3,4-DIHYDROCOUMARIN
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
150MG/KG = 2
300MG/KG = 3
600MG/KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 13
| 4 2 13 2 12 41 3 3
| 2 41 3 1
| 22 4 1 1
P 90 + 2 42 11 3
E | 2 2 1 33 1
R | 4 4 4 2 2 331 11
C | 4 2 2 33 1 1
E 80 + 44 22 1 1
N | 2 32 3
T | 4 4 2 2 331 1
| 4 4 2 2 33 111
S 70 + 44 22 33 11
U | 2 2
R | 4 42332 1 1
V | 44 22
I 60 + 4 3 3
V | 33
A | 223
L | 443 3
50 + 4 4
|
| 2 2
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 22 obs hidden.