TDMS Study 05092-03 Pathology Tables
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
Facility: Southern Research Institute
Chemical CAS #: 0091-23-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 10 10 10 10 20
Scheduled Sacrifice 10 10 10 8
Early Deaths
Natural Death 2 4
Moribund Sacrifice 4 2 12
Survivors
Terminal Sacrifice 14 4
Animals Examined Microscopically 20 10 10 10 10 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (1) (5)
Parasite Metazoan 1 (20%)
Liver (20) (10) (10) (10) (10) (20)
Basophilic Focus 1 (5%) 5 (50%) 2 (10%)
Basophilic Focus, Multiple 14 (70%) 7 (70%) 9 (45%)
Eosinophilic Focus 4 (20%) 1 (5%)
Eosinophilic Focus, Multiple 1 (5%) 1 (5%)
Hematopoietic Cell Proliferation 1 (10%)
Hepatodiaphragmatic Nodule 2 (10%) 1 (10%) 3 (15%)
Inflammation, Granulomatous, Multifocal 1 (10%)
Inflammation, Granulomatous, Multiple 14 (70%) 4 (40%) 5 (50%) 2 (20%) 10 (50%)
Mixed Cell Focus 4 (20%) 1 (5%)
Vacuolization Cytoplasmic 3 (15%) 1 (10%)
Bile Duct, Hyperplasia 5 (25%) 2 (20%) 1 (5%)
Hepatocyte, Hypertrophy 3 (30%) 2 (10%)
Hepatocyte, Mitotic Alteration 1 (10%)
Hepatocyte, Necrosis, Multifocal 1 (10%)
Hepatocyte, Kupffer Cell, Pigmentation 8 (40%) 1 (10%) 1 (10%) 2 (10%)
Mesentery (1) (1) (2) (2)
Fat, Necrosis, Focal 1 (100%) 1 (100%) 2 (100%) 2 (100%)
Stomach, Forestomach (5) (9)
Diverticulum 1 (20%)
Edema 1 (20%) 1 (11%)
Ulcer 1 (20%)
Epithelium, Hyperplasia 2 (40%) 4 (44%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (2)
Inflammation, Chronic 1 (50%)
Mineralization, Multifocal 1 (50%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (2)
Bilateral, Vacuolization Cytoplasmic 1 (50%)
Pituitary Gland (12) (1) (8)
Pars Distalis, Cyst 1 (13%)
Pars Distalis, Hemorrhage 3 (25%)
Pars Distalis, Hyperplasia, Focal 2 (25%)
Thyroid Gland (1) (1)
C-Cell, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (3) (2) (5)
Inflammation, Suppurative 1 (33%)
Duct, Cyst 5 (100%)
Ovary (1) (1) (1)
Cyst 1 (100%) 1 (100%) 1 (100%)
Uterus (19) (10) (10) (10) (10) (20)
Atrophy 1 (5%)
Dilatation 2 (11%) 1 (10%) 2 (20%) 2 (10%)
Fibrosis, Focal 1 (5%)
Inflammation, Suppurative 2 (11%)
Cervix, Cyst 1 (5%)
Cervix, Myometrium, Hypertrophy 1 (5%) 2 (10%)
Endometrium, Hyperplasia, Cystic 3 (16%) 2 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (14) (16)
Deep Cervical, Angiectasis 1 (7%)
Iliac, Hyperplasia, Lymphoid 1 (6%)
Mediastinal, Angiectasis 2 (14%) 9 (56%)
Mediastinal, Hyperplasia, Lymphoid 1 (7%) 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Pigmentation 3 (21%) 2 (13%)
Pancreatic, Angiectasis 2 (14%)
Pancreatic, Pigmentation 1 (6%)
Lymph Node, Mandibular (7) (2)
Cyst 1 (14%) 1 (50%)
Cyst, Multiple 1 (14%)
Hyperplasia, Lymphoid 2 (29%)
Spleen (20) (10) (10) (10) (10) (20)
Atrophy 2 (10%)
Congestion 11 (55%) 3 (30%) 5 (50%) 7 (35%)
Depletion Lymphoid 4 (20%) 5 (25%)
Hematopoietic Cell Proliferation 15 (75%) 1 (10%) 4 (40%) 12 (60%)
Hyperplasia, Histiocytic, Lymphoid 1 (5%) 1 (5%)
Hyperplasia, Lymphoid 1 (5%)
Pigmentation 15 (75%) 10 (100%) 5 (50%) 5 (50%) 6 (60%) 12 (60%)
Capsule, Hypertrophy 9 (45%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (1) (5)
Hyperplasia, Lobular 8 (62%) 1 (20%)
Duct, Cyst 9 (69%) 3 (60%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2) (3)
Calvarium, Hyperostosis 2 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (5) (2)
Compression 4 (80%)
Hydrocephalus 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (2) (1) (1)
Congestion 1 (50%)
Infiltration Cellular, Histiocyte 1 (50%)
Alveolar Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
Retina, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (10) (10) (10) (10) (20)
Hydronephrosis 2 (10%)
Inflammation, Suppurative 1 (5%)
Nephropathy, Chronic 18 (90%) 5 (50%) 6 (60%) 12 (60%)
Bilateral, Hydronephrosis 1 (5%)
Corticomedullary Junction, Mineralization 9 (90%) 2 (20%)
Papilla, Necrosis 2 (10%)
Pelvis, Hemorrhage 1 (5%)
Pelvis, Inflammation, Suppurative 1 (5%)
Pelvis, Mineralization 5 (25%) 1 (10%) 2 (20%) 4 (20%)
Renal Tubule, Mineralization 17 (85%) 3 (30%) 9 (90%) 8 (80%) 9 (45%)
Renal Tubule, Pigmentation 18 (90%) 6 (60%) 9 (90%) 20 (100%)
Renal Tubule, Regeneration 2 (10%)
Transitional Epithelium, Hyperplasia 5 (25%)
Ureter (18) (10) (9) (10) (9) (17)
Dilatation 5 (29%)
Urinary Bladder (18) (10) (10) (10) (10) (20)
Hemorrhage 2 (10%)
Inflammation, Suppurative 1 (5%)
Metaplasia, Squamous 6 (30%)
Necrosis 3 (15%)
Transitional Epithelium, Hyperplasia 4 (20%)
Wall, Infiltration Cellular, Lipocyte 3 (15%)
Wall, Proliferation Connective Tissue 11 (55%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 20 10
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Natural Death 5
Moribund Sacrifice 15
Survivors
Animals Examined Microscopically 10 10 10 10 20 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (1) (2) (10)
Parasite Metazoan 1 (10%)
Epithelium, Hyperplasia 1 (10%)
Liver (10) (10) (10) (9) (20) (10)
Basophilic Focus 2 (20%) 1 (11%)
Basophilic Focus, Multiple 2 (22%)
Hepatodiaphragmatic Nodule 1 (10%) 1 (5%) 1 (10%)
Inflammation, Granulomatous, Multiple 5 (50%) 4 (44%) 15 (75%)
Vacuolization Cytoplasmic 1 (10%)
Bile Duct, Hyperplasia 1 (5%)
Hepatocyte, Hypertrophy 1 (5%) 10 (100%)
Hepatocyte, Necrosis, Multifocal 3 (30%) 1 (5%) 10 (100%)
Hepatocyte, Vacuolization Cytoplasmic 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic,
Multifocal 1 (10%)
Hepatocyte, Kupffer Cell, Pigmentation 9 (90%) 7 (70%) 2 (22%) 20 (100%) 10 (100%)
Kupffer Cell, Pigmentation, Multifocal 1 (10%)
Mesentery (1) (5) (2)
Fat, Inflammation, Chronic 4 (80%)
Fat, Necrosis, Focal 1 (100%) 1 (20%)
Pancreas (3)
Ectopic Tissue 1 (33%)
Stomach, Forestomach (1) (7)
Epithelium, Hyperplasia 1 (100%) 1 (14%)
Stomach, Glandular (1) (7)
Mineralization 1 (14%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (1)
Duct, Cyst 1 (100%) 1 (100%)
Ovary (1) (1)
Cyst 1 (100%)
Oviduct (1)
Cyst 1 (100%)
Uterus (10) (10) (10) (10) (20) (10)
Atrophy 10 (100%) 10 (100%) 20 (100%) 10 (100%)
Dilatation 3 (30%) 1 (10%)
Cervix, Cyst 1 (10%)
Endometrium, Hyperplasia, Cystic 1 (10%)
Epithelium, Hyperplasia, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2) (5)
Iliac, Hyperplasia, Lymphoid 4 (80%)
Mediastinal, Angiectasis 1 (50%)
Mediastinal, Hyperplasia, Lymphoid 1 (50%)
Mediastinal, Pigmentation 1 (50%)
Spleen (10) (10) (10) (10) (20) (10)
Congestion 10 (100%) 10 (100%) 10 (100%) 3 (30%) 17 (85%) 10 (100%)
Depletion Lymphoid 8 (40%) 10 (100%)
Hematopoietic Cell Proliferation 1 (10%) 8 (80%) 15 (75%)
Hyperplasia, Lymphoid 1 (5%)
Hypertrophy 1 (10%)
Pigmentation 10 (100%) 10 (100%) 10 (100%) 7 (70%) 8 (40%) 10 (100%)
Capsule, Hypertrophy 10 (100%) 10 (100%) 8 (80%) 9 (90%) 20 (100%) 10 (100%)
Capsule, Inflammation, Chronic 6 (60%) 2 (20%) 1 (10%) 17 (85%) 9 (90%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (2) (2)
Infiltration Cellular, Multifocal, Lymphocyte 2 (100%)
Inflammation, Chronic, Multifocal 2 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (20) (10)
Hydronephrosis 11 (55%)
Nephropathy, Chronic 3 (30%) 5 (50%) 2 (10%)
Bilateral, Hydronephrosis 3 (15%)
Corticomedullary Junction, Mineralization 9 (90%) 9 (90%)
Papilla, Necrosis 1 (5%)
Pelvis, Dilatation 2 (10%)
Pelvis, Inflammation, Suppurative 1 (10%)
Pelvis, Mineralization 1 (10%) 2 (20%) 8 (40%)
Pelvis, Necrosis 1 (5%)
Proximal Convoluted Renal Tubule,
Degeneration, Hyaline 1 (10%)
Renal Tubule, Mineralization 4 (40%) 8 (80%) 9 (90%) 9 (45%)
Renal Tubule, Pigmentation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 20 (100%) 10 (100%)
Renal Tubule, Regeneration 1 (10%) 2 (10%)
Transitional Epithelium, Hyperplasia 1 (10%) 9 (45%)
Ureter (10) (10) (10) (10) (19) (10)
Dilatation 1 (10%) 15 (79%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 2 (11%)
Urinary Bladder (10) (10) (9) (10) (20) (10)
Hemorrhage 2 (10%)
Inflammation, Subacute 5 (50%) 1 (5%) 8 (80%)
Inflammation, Suppurative 1 (10%) 5 (25%)
Metaplasia, Squamous 2 (20%) 13 (65%) 10 (100%)
Necrosis 1 (10%) 1 (5%)
Transitional Epithelium, Hyperplasia 8 (80%) 10 (100%) 9 (100%) 3 (30%) 1 (5%) 10 (100%)
Transitional Epithelium, Metaplasia, Squamous 1 (10%)
Wall, Infiltration Cellular, Lipocyte 2 (10%)
Wall, Proliferation Connective Tissue 2 (20%) 1 (11%) 6 (60%) 14 (70%) 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 1.80% 1.80% 1.80%
6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10
Scheduled Sacrifice 10 6
Early Deaths
Natural Death 2 2
Moribund Sacrifice 2 8
Survivors
Animals Examined Microscopically 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (3) (9)
Ulcer 1 (11%)
Intestine Large, Colon (3) (9)
Autolysis 1 (11%)
Intussusception 1 (11%)
Necrosis 1 (11%)
Parasite Metazoan 1 (33%)
Proliferation Connective Tissue 1 (11%)
Epithelium, Hyperplasia 1 (33%) 3 (33%)
Intestine Large, Rectum (3) (9)
Autolysis 1 (11%)
Liver (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 1 (10%)
Inflammation, Granulomatous, Multiple 5 (50%) 10 (100%) 9 (90%)
Hepatocyte, Hypertrophy 10 (100%) 1 (10%)
Hepatocyte, Necrosis, Multifocal 10 (100%)
Hepatocyte, Vacuolization Cytoplasmic 1 (10%)
Hepatocyte, Kupffer Cell, Pigmentation 10 (100%) 10 (100%) 10 (100%)
Pancreas (1)
Acinus, Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 1.80% 1.80% 1.80%
6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Uterus (10) (10) (10)
Atrophy 10 (100%) 7 (70%) 4 (40%)
Dilatation 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (3) (5)
Iliac, Hyperplasia, Lymphoid 3 (60%)
Mediastinal, Hyperplasia, Lymphoid 1 (20%)
Pancreatic, Hyperplasia, Lymphoid 1 (33%)
Lymph Node, Mesenteric (1)
Angiectasis 1 (100%)
Spleen (10) (10) (10)
Atrophy 1 (10%)
Congestion 10 (100%) 6 (60%) 6 (60%)
Depletion Lymphoid 10 (100%) 2 (20%) 6 (60%)
Hematopoietic Cell Proliferation 6 (60%) 4 (40%)
Pigmentation 9 (90%) 7 (70%) 4 (40%)
Capsule, Hypertrophy 10 (100%) 10 (100%) 9 (90%)
Capsule, Inflammation, Chronic 10 (100%) 10 (100%) 9 (90%)
Thymus (2)
Atrophy 1 (50%)
Congestion 1 (50%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 1.80% 1.80% 1.80%
6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Edema 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Hydronephrosis 1 (10%) 3 (30%)
Nephropathy, Chronic 4 (40%)
Corticomedullary Junction, Mineralization 2 (20%)
Papilla, Necrosis 1 (10%)
Pelvis, Mineralization 3 (30%) 4 (40%)
Pelvis, Necrosis 1 (10%)
Renal Tubule, Mineralization 7 (70%) 5 (50%)
Renal Tubule, Pigmentation 10 (100%) 10 (100%) 10 (100%)
Renal Tubule, Regeneration 1 (10%)
Transitional Epithelium, Hyperplasia 2 (20%) 3 (30%) 5 (50%)
Ureter (10) (10) (10)
Dilatation 3 (30%) 3 (30%)
Urinary Bladder (10) (10) (10)
Hemorrhage 1 (10%) 2 (20%)
Inflammation, Subacute 10 (100%) 1 (10%)
Inflammation, Suppurative 3 (30%) 2 (20%)
Metaplasia, Squamous 10 (100%) 8 (80%) 8 (80%)
Wall, Proliferation Connective Tissue 10 (100%) 5 (50%) 5 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 10 10 10 10 20
Scheduled Sacrifice 10 10 10 9
Early Deaths
Moribund Sacrifice 6 1 19
Natural Death 1
Survivors
Terminal Sacrifice 13 1
Animals Examined Microscopically 20 10 10 10 10 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (1) (15)
Edema 2 (13%)
Parasite Metazoan 1 (7%)
Submucosa, Proliferation Connective Tissue 1 (7%)
Intestine Large, Colon (1) (15)
Edema 1 (7%)
Fibrosis 1 (7%)
Hemorrhage 2 (13%)
Serosa, Inflammation, Chronic 1 (7%)
Intestine Large, Rectum (1) (15)
Hemorrhage 1 (7%)
Liver (20) (10) (10) (10) (10) (20)
Basophilic Focus 1 (5%) 1 (10%) 3 (30%) 2 (10%)
Basophilic Focus, Multiple 8 (40%) 1 (10%) 3 (15%)
Clear Cell Focus 1 (5%) 1 (10%) 1 (5%)
Clear Cell Focus, Multiple 4 (20%)
Degeneration, Cystic 1 (5%)
Eosinophilic Focus 5 (25%) 1 (10%) 2 (10%)
Eosinophilic Focus, Multiple 2 (10%) 1 (5%)
Hematopoietic Cell Proliferation 1 (10%) 2 (10%)
Hepatodiaphragmatic Nodule 2 (10%) 2 (20%) 1 (10%) 1 (5%)
Hyperplasia, Nodular 5 (25%)
Inflammation, Granulomatous, Multiple 4 (20%) 3 (30%) 7 (70%) 6 (30%)
Mixed Cell Focus 1 (5%) 1 (5%)
Mixed Cell Focus, Multiple 1 (5%)
Necrosis, Focal 1 (10%)
Thrombosis 1 (5%)
Vacuolization Cytoplasmic 1 (5%) 4 (40%) 2 (10%)
Bile Duct, Hyperplasia 20 (100%) 6 (60%) 9 (90%) 7 (35%)
Centrilobular, Degeneration 1 (5%)
Hepatocyte, Necrosis, Multiple 1 (10%) 1 (5%)
Hepatocyte, Kupffer Cell, Pigmentation 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Serosa, Fibrosis 1 (5%)
Mesentery (2) (1) (2) (2)
Thrombosis 1 (50%)
Fat, Necrosis, Focal 2 (100%) 1 (100%) 2 (100%)
Pancreas (1) (4)
Edema 1 (25%)
Polyarteritis 1 (100%)
Acinar Cell, Atrophy 1 (25%)
Acinar Cell, Hyperplasia 1 (25%)
Stomach, Forestomach (3) (1) (9)
Abscess 2 (22%)
Edema 1 (11%)
Inflammation, Suppurative 1 (33%)
Mineralization 1 (11%)
Ulcer 2 (67%)
Ulcer, Multiple 1 (33%)
Epithelium, Hyperplasia 1 (33%) 4 (44%)
Stomach, Glandular (3) (1) (9)
Erosion, Multiple 1 (33%)
Mineralization 2 (22%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (4) (2) (2)
Inflammation, Chronic 4 (100%) 2 (100%)
Mineralization 1 (50%)
Atrium, Congestion 1 (25%) 2 (100%)
Atrium, Dilatation 1 (25%)
Atrium, Thrombosis 2 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (2) (2)
Vacuolization Cytoplasmic 1 (50%)
Vacuolization Cytoplasmic, Focal 1 (50%)
Parathyroid Gland (2)
Hyperplasia 2 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (20) (10) (10) (10) (10) (20)
Depletion Cellular 17 (85%) 12 (60%)
Preputial Gland (6) (1) (6)
Atrophy 2 (33%) 3 (50%)
Hyperplasia 1 (17%)
Inflammation, Suppurative 2 (33%)
Necrosis 1 (17%)
Duct, Cyst 2 (33%) 4 (67%)
Duct, Cyst, Multiple 1 (17%)
Prostate (1)
Inflammation, Chronic 1 (100%)
Seminal Vesicle (2)
Atrophy 2 (100%)
Testes (20) (10) (10) (10) (10) (20)
Degeneration, Focal 1 (10%)
Bilateral, Interstitial Cell, Hyperplasia 2 (20%)
Interstitial Cell, Hyperplasia 2 (10%) 4 (40%) 9 (45%)
Seminiferous Tubule, Atrophy 20 (100%) 13 (65%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (13) (2) (14)
Deep Cervical, Angiectasis 1 (8%)
Iliac, Hyperplasia, Lymphoid 1 (7%)
Mediastinal, Angiectasis 2 (15%) 3 (21%)
Mediastinal, Congestion 1 (7%)
Mediastinal, Hemorrhage 2 (15%)
Mediastinal, Pigmentation 3 (21%)
Pancreatic, Angiectasis 1 (8%) 1 (7%)
Pancreatic, Edema 1 (7%)
Pancreatic, Hemorrhage 1 (8%)
Pancreatic, Hyperplasia, Lymphoid 1 (50%) 1 (7%)
Renal, Angiectasis 1 (8%) 1 (7%)
Renal, Inflammation, Granulomatous 1 (7%)
Lymph Node, Mandibular (5) (1) (7)
Hemorrhage 1 (20%)
Hyperplasia, Lymphoid 1 (100%) 3 (43%)
Lymph Node, Mesenteric (5) (1) (8)
Angiectasis 2 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (13%)
Cyst 2 (25%)
Edema 3 (38%)
Hemorrhage 1 (20%)
Hyperplasia, Lymphoid 1 (20%) 1 (100%)
Spleen (20) (10) (10) (10) (10) (20)
Congestion 5 (25%) 7 (70%) 11 (55%)
Depletion Lymphoid 1 (5%)
Fibrosis 1 (5%) 1 (5%)
Fibrosis, Focal 1 (5%)
Hematopoietic Cell Proliferation 9 (45%) 4 (40%) 14 (70%)
Inflammation, Granulomatous 1 (5%)
Pigmentation 5 (25%) 10 (100%) 10 (100%) 7 (70%) 11 (55%)
Capsule, Hypertrophy 9 (45%)
Capsule, Inflammation, Chronic 1 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (1) (1)
Duct, Cyst 1 (100%)
Skin (2) (2) (1)
Epidermis, Fibrosis, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (1)
Calvarium, Hyperostosis 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (5)
Compression 2 (40%)
Hemorrhage, Multiple 1 (20%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (7) (1) (1)
Inflammation, Granulomatous 1 (14%)
Alveolar Epithelium, Hyperplasia 1 (14%)
Alveolus, Pigmentation 1 (14%)
Nose (1)
Lumen, Hyperkeratosis 1 (100%)
Lumen, Inflammation, Suppurative 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0% 0.0% 0.0% 0.600%
3 SSAC 6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (10) (10) (10) (10) (20)
Nephropathy 2 (20%)
Nephropathy, Chronic 20 (100%) 2 (20%) 4 (40%) 10 (100%) 10 (100%) 20 (100%)
Cortex, Cyst 1 (5%)
Pelvis, Inflammation, Suppurative 1 (10%)
Pelvis, Mineralization 16 (80%) 4 (40%) 3 (30%) 20 (100%)
Renal Tubule, Hyperplasia 1 (5%)
Renal Tubule, Pigmentation 19 (95%) 2 (20%) 10 (100%) 10 (100%) 20 (100%)
Transitional Epithelium, Hyperplasia 5 (25%) 20 (100%)
Ureter (18) (9) (10) (10) (10) (20)
Dilatation 1 (10%) 3 (15%)
Transitional Epithelium, Hyperplasia 1 (5%)
Urethra (2)
Bulbourethral Gland, Cyst, Multiple 1 (50%)
Urinary Bladder (20) (9) (10) (10) (10) (20)
Hemorrhage 1 (5%)
Metaplasia, Squamous 1 (5%)
Necrosis 1 (5%)
Transitional Epithelium, Hyperplasia 6 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 20 10
Scheduled Sacrifice 10 10 10 3 10
Early Deaths
Moribund Sacrifice 7 14
Natural Death 6
Survivors
Animals Examined Microscopically 10 10 10 10 20 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (2) (9) (18)
Dilatation 1 (6%)
Intestine Large, Colon (2) (9) (18)
Hemorrhage 2 (11%)
Intussusception 4 (22%)
Parasite Metazoan 1 (6%)
Epithelium, Hyperplasia 4 (22%)
Serosa, Inflammation, Chronic 1 (6%)
Wall, Proliferation Connective Tissue 1 (6%)
Intestine Large, Rectum (2) (9) (18)
Epithelium, Hyperplasia 1 (6%)
Liver (10) (10) (10) (10) (20) (10)
Basophilic Focus 1 (10%)
Eosinophilic Focus 1 (5%)
Hematopoietic Cell Proliferation 1 (5%)
Hepatodiaphragmatic Nodule 1 (10%) 1 (5%)
Inflammation, Granulomatous, Multifocal 1 (10%)
Inflammation, Granulomatous, Multiple 1 (10%) 9 (90%) 9 (90%) 8 (40%)
Vacuolization Cytoplasmic 3 (30%) 1 (5%)
Artery, Inflammation, Chronic, Focal 1 (10%)
Hepatocyte, Hypertrophy 2 (10%) 10 (100%)
Hepatocyte, Necrosis, Multifocal 1 (10%) 1 (5%) 10 (100%)
Hepatocyte, Vacuolization Cytoplasmic 3 (30%)
Hepatocyte, Vacuolization Cytoplasmic,
Multifocal 3 (30%)
Hepatocyte, Kupffer Cell, Pigmentation 3 (30%) 1 (10%) 18 (90%) 10 (100%)
Stomach, Forestomach (2) (1) (5)
Inflammation, Suppurative 1 (20%)
Ulcer 1 (20%)
Epithelium, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10) (20) (10)
Depletion Cellular 5 (25%) 10 (100%)
Preputial Gland (1)
Hyperplasia 1 (100%)
Prostate (3) (1)
Inflammation, Suppurative 1 (33%) 1 (100%)
Seminal Vesicle (1) (1)
Adventitia, Edema 1 (100%)
Testes (10) (10) (10) (10) (20) (10)
Atrophy 9 (90%)
Degeneration 10 (100%)
Edema 7 (70%)
Bilateral, Interstitial Cell, Hyperplasia 1 (10%)
Interstitial Cell, Hyperplasia 2 (20%) 3 (30%)
Seminiferous Tubule, Atrophy 15 (75%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (3) (3)
Bronchial, Hyperplasia, Lymphoid 1 (33%)
Iliac, Angiectasis 1 (33%)
Mediastinal, Hyperplasia, Lymphoid 2 (67%)
Pancreatic, Hyperplasia 1 (100%)
Renal, Angiectasis 1 (33%)
Lymph Node, Mesenteric (2) (1)
Cyst 1 (50%)
Fibrosis 1 (100%)
Hyperplasia, Lymphoid 1 (50%)
Spleen (10) (10) (10) (10) (20) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 9 (90%) 10 (100%) 10 (100%) 5 (50%) 16 (80%) 10 (100%)
Depletion Lymphoid 13 (65%) 10 (100%)
Fibrosis 3 (15%)
Hematopoietic Cell Proliferation 2 (20%) 7 (70%) 7 (35%)
Hyperplasia, Lymphoid 2 (20%)
Pigmentation 10 (100%) 10 (100%) 10 (100%) 5 (50%) 12 (60%) 10 (100%)
Capsule, Hypertrophy 10 (100%) 7 (70%) 8 (80%) 8 (80%) 20 (100%) 10 (100%)
Capsule, Inflammation, Chronic 1 (10%) 2 (20%) 5 (50%) 20 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (2) (2) (2) (1) (1)
Congestion 2 (100%)
Infiltration Cellular, Multifocal, Lymphocyte 2 (100%) 1 (50%) 1 (100%)
Inflammation 1 (50%)
Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Edema 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (20) (10)
Hydronephrosis 5 (25%)
Infarct 3 (15%)
Nephropathy, Chronic 10 (100%) 10 (100%) 10 (100%) 10 (100%) 14 (70%) 7 (70%)
Pigmentation 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.600% 0.600% 0.600% 0.600% 1.80% 1.80%
3 SSAC 6 SSAC 9 SSAC 15 SSAC 3 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Bilateral, Hydronephrosis 2 (20%)
Papilla, Necrosis 1 (5%)
Pelvis, Dilatation 1 (10%) 1 (5%)
Pelvis, Mineralization 9 (90%) 10 (100%) 10 (100%) 13 (65%)
Renal Tubule, Degeneration 10 (100%)
Renal Tubule, Dilatation 1 (5%)
Renal Tubule, Mineralization 10 (100%) 1 (10%) 2 (10%)
Renal Tubule, Necrosis 10 (100%) 1 (5%)
Renal Tubule, Pigmentation 9 (90%) 9 (90%) 10 (100%) 9 (90%) 20 (100%) 10 (100%)
Renal Tubule, Regeneration 10 (100%) 3 (30%) 3 (15%)
Transitional Epithelium, Hyperplasia 7 (70%) 7 (70%) 11 (55%)
Ureter (10) (10) (10) (8) (20) (10)
Dilatation 2 (25%) 6 (30%)
Urethra (1)
Transitional Epithelium, Hyperplasia 1 (100%)
Urinary Bladder (9) (10) (10) (10) (20) (10)
Hemorrhage 3 (15%)
Inflammation, Subacute 10 (100%)
Inflammation, Suppurative 1 (10%) 3 (15%)
Metaplasia, Squamous 2 (20%) 18 (90%) 10 (100%)
Transitional Epithelium, Hyperplasia 10 (100%) 9 (90%) 4 (40%) 1 (5%) 9 (90%)
Wall, Proliferation Connective Tissue 1 (10%) 2 (20%) 15 (75%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 1.80% 1.80% 1.80%
6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10
Scheduled Sacrifice 10 6
Early Deaths
Moribund Sacrifice 3 6
Natural Death 1 4
Survivors
Animals Examined Microscopically 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (3) (5) (9)
Dilatation 1 (11%)
Intestine Large, Colon (3) (5) (9)
Hemorrhage 2 (22%)
Intussusception 2 (22%)
Necrosis 1 (11%)
Parasite Metazoan 1 (20%)
Epithelium, Hyperplasia 1 (33%) 1 (20%) 5 (56%)
Liver (10) (10) (10)
Cyst 1 (10%)
Eosinophilic Focus, Multiple 1 (10%)
Inflammation, Granulomatous, Multiple 1 (10%) 8 (80%) 5 (50%)
Hepatocyte, Hypertrophy 10 (100%) 1 (10%) 3 (30%)
Hepatocyte, Necrosis, Multifocal 10 (100%)
Hepatocyte, Vacuolization Cytoplasmic 6 (60%)
Hepatocyte, Kupffer Cell, Pigmentation 10 (100%) 9 (90%) 8 (80%)
Stomach, Forestomach (2)
Epithelium, Hyperplasia 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 1.80% 1.80% 1.80%
6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10)
Depletion Cellular 10 (100%) 3 (30%) 2 (20%)
Prostate (4)
Inflammation, Suppurative 2 (50%)
Proliferation Connective Tissue 1 (25%)
Epithelium, Hyperplasia 1 (25%)
Seminal Vesicle (1)
Epithelium, Hyperplasia 1 (100%)
Testes (10) (10) (10)
Atrophy 10 (100%)
Degeneration 10 (100%)
Seminiferous Tubule, Atrophy 5 (50%) 4 (40%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (3)
Iliac, Hyperplasia, Lymphoid 1 (33%)
Pancreatic, Hyperplasia, Lymphoid 2 (67%)
Spleen (10) (10) (10)
Congestion 10 (100%) 6 (60%) 6 (60%)
Depletion Lymphoid 10 (100%) 2 (20%) 5 (50%)
Fibrosis 2 (20%) 1 (10%)
Hematopoietic Cell Proliferation 6 (60%) 4 (40%)
Inflammation, Chronic 1 (10%)
Pigmentation 8 (80%) 3 (30%) 5 (50%)
Thrombosis 1 (10%)
Capsule, Hypertrophy 10 (100%) 10 (100%) 10 (100%)
Capsule, Inflammation, Chronic 10 (100%) 10 (100%) 9 (90%)
Thymus (2)
Atrophy 2 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 1.80% 1.80% 1.80%
6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Fibrosis 1 (10%)
Hydronephrosis 4 (40%) 3 (30%)
Nephropathy, Chronic 10 (100%) 9 (90%) 7 (70%)
Pigmentation 1 (10%)
Bilateral, Hydronephrosis 1 (10%)
Pelvis, Dilatation 1 (10%)
Pelvis, Mineralization 1 (10%) 2 (20%) 7 (70%)
Pelvis, Necrosis 1 (10%)
Renal Tubule, Mineralization 1 (10%) 1 (10%)
Renal Tubule, Pigmentation 9 (90%) 10 (100%) 10 (100%)
Renal Tubule, Regeneration 10 (100%) 4 (40%) 1 (10%)
Transitional Epithelium, Hemorrhage 1 (10%)
Transitional Epithelium, Hyperplasia 5 (50%) 4 (40%) 7 (70%)
Ureter (9) (10) (10)
Dilatation 4 (40%) 5 (50%)
Hemorrhage 1 (10%)
Inflammation, Chronic 1 (10%)
Transitional Epithelium, Hyperplasia 1 (11%) 1 (10%)
Urinary Bladder (10) (10) (10)
Cyst, Multiple 1 (10%)
Hemorrhage 2 (20%) 1 (10%)
Inflammation, Subacute 7 (70%) 3 (30%)
Inflammation, Suppurative 3 (30%)
Metaplasia, Squamous 10 (100%) 6 (60%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 24
NTP Experiment-Test: 05092-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97
Route: DOSED FEED Time: 13:45:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 1.80% 1.80% 1.80%
6 SSAC 9 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (10%)
Wall, Proliferation Connective Tissue 9 (90%) 7 (70%) 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 25
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---------- END OF REPORT ----------
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