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TDMS Study 05092-03 Pathology Tables

NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97
Route: DOSED FEED                                                                                                 Time: 13:30:04




       Facility:  Southern Research Institute

       Chemical CAS #:  0091-23-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2|              |            |
                                           | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +        A                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +        +                                                         |   2        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +        A                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +        A                                                         |   1        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +        A                                                         |   1        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |    X  X                 X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +              +                       +     +                     |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +              +                       +     +                     |   5        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Squamous Cell Papilloma              |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +              +                       +     +                     |   5        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +                                                                  |   2        |
      Leukemia Mononuclear                 |    X  X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +                                                                  |   2        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                      +                                                   |   1        |
      Carcinoma                            |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +     +  +  +  +  +           +  +                     |  12        |
      Pars Distalis, Adenoma               |    X  X  X  X     X     X  X  X  X  X           X  X                     |         12 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                           +                              |   1        |
      Follicular Cell, Carcinoma           |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   2                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2|              |            |
                                           | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             +                                      +     +               |   3        |
      Adenoma                              |                                                    X                     |          1 |
      Carcinoma                            |             X                                            X               |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  19        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Polyp Stromal                        |                                        X                 X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +        +  +  +  +  +  +  +  +  +     +     +                  |  14        |
      Deep Cervical, Leukemia Mononuclear  |       X                                                                  |          1 |
      Iliac, Leukemia Mononuclear          |    X                                                                     |          1 |
      Mediastinal, Leukemia Mononuclear    |    X                    X                                                |          2 |
      Pancreatic, Leukemia Mononuclear     |    X  X                 X                                                |          3 |
      Renal, Leukemia Mononuclear          |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +              +  +  +  +        +  +                              |   7        |
      Leukemia Mononuclear                 |       X                 X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +                                                                  |   2        |
      Leukemia Mononuclear                 |    X  X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |    X  X                 X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                                                                  |   1        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +        +  +  +  +  +  +  +        +     +                  |  13        |
      Fibroadenoma                         |       X     X        X           X  X  X                                 |          6 |
      Fibroadenoma, Multiple               |          X                                                               |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                              +                           |   1        |
      Head, Squamous Cell Carcinoma, Deep  |                                                                          |            |
          Invasion                         |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                                      +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                       +     +                                    |   5        |
      Glioma Malignant                     | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   3                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2|              |            |
                                           | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +                                      +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +               |  18        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |    X  X                 X                                                |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   4                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 8| 8| 8| 7| 7| 7| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     3 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 0| 1| 0| 0| 0| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
     6 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 4| 5| 5| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
     9 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 8| 3| 5| 5| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +  +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             +        +                                                   |   2        |
      Adenoma                              |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Polyp Stromal                        |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   +                                                      |   1        |
      Fibroadenoma                         |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
      Hindlimb, Rhabdomyosarcoma           |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 8| 3| 5| 5| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3|              |            |
                             DAY ON TEST   | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0|              |            |
                                           | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +  +     +     +              +  +     +     +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +  +     +     +              +  +     +     +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +  +     +     +              +  +     +     +               |  10        |
      Polyp Adenomatous                    |                X                             X                           |          2 |
      Polyp Adenomatous, Multiple          |       X  X  X        X     X                       X     X               |          7 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +  +     +     +              +  +     +     +               |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   2        |
      Sarcoma, Multiple, Metastatic,       |                                                                          |            |
          Urinary Bladder                  |    X                                                                     |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +                                               +                  |   3        |
      Sarcoma, Metastatic, Urinary Bladder |    X                                                                     |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +     +     +  +     +              +                              |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +     +  +     +              +                              |   7        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
      Squamous Cell Papilloma              |                   X  X     X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +     +  +     +              +                              |   7        |
      Serosa, Sarcoma, Metastatic, Urinary |                                                                          |            |
          Bladder                          |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                                                                  |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3|              |            |
                             DAY ON TEST   | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0|              |            |
                                           | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +                                                                  |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
      Cervix, Carcinoma, Metastatic,       |                                                                          |            |
          Urinary Bladder                  |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +              +           +           +                           |   5        |
      Iliac, Squamous Cell Carcinoma,      |                                                                          |            |
          Metastatic, Urinary Bladder      |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                                                  |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Capsule, Squamous Cell Carcinoma,    |                                                                          |            |
           Metastatic, Urinary Bladder     |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                                                                  |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +                 +                                                |   2        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3|              |            |
                             DAY ON TEST   | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0|              |            |
                                           | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |       X                                                                  |          1 |
      Transitional Epithelium, Carcinoma   |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  19        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leiomyosarcoma                       |          X                                                               |          1 |
      Sarcoma                              |    X        X              X                 X        X  X               |          6 |
      Squamous Cell Carcinoma              |       X                                                                  |          1 |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X               |         19 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    1.80%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X  X  X  X  X  X                                             |         10 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7|                                            |            |
                                           | 4| 4| 5| 5| 5| 3| 5| 7| 2| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    1.80%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +     +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +              +     +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              +     +                                                   |   3        |
      Polyp Adenomatous, Multiple          | X              X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +     +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +                                                      |   1        |
      Squamous Cell Papilloma              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +        +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7|                                            |            |
                                           | 4| 4| 5| 5| 5| 3| 5| 7| 2| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |     A      |
    1.80%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Sarcoma                              |          X              X  X                                             |          3 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X  X  X  X  X  X                                             |         10 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 0| 2| 2| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3|                                            |            |
                                           | 5| 7| 5| 5| 6| 4| 1| 8| 9| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +                                             |   9        |
      Carcinoma                            |    X                       X                                             |          2 |
      Polyp Adenomatous                    |    X                 X  X                                                |          3 |
      Polyp Adenomatous, Multiple          |       X  X  X              X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cervix, Leiomyosarcoma               | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +     +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 0| 2| 2| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3|                                            |            |
                                           | 5| 7| 5| 5| 6| 4| 1| 8| 9| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Papilloma   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Fibrosarcoma                         |                         X                                                |          1 |
      Leiomyosarcoma                       |                            X                                             |          1 |
      Sarcoma                              |       X           X                                                      |          2 |
      Squamous Cell Papilloma              |                            X                                             |          1 |
      Squamous Cell Papilloma, Multiple    | X        X                                                               |          2 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X     X  X  X  X                                             |          9 |
      Transitional Epithelium, Papilloma,  |                                                                          |            |
           Multiple                        | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7|              |            |
                             DAY ON TEST   | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2|              |            |
                                           | 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |     A      |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +     +  +                             +                     |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +     +  +                             +                     |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +     +  +                             +                     |   5        |
      Polyp Adenomatous                    | X           X     X                                                      |          3 |
      Polyp Adenomatous, Multiple          |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +     +  +                             +                     |   5        |
      Polyp Adenomatous, Multiple          |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                   +                        |   2        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +        +  +  +     +     +                 +                  |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +        +  +  +     +     +                 +                  |   9        |
      Squamous Cell Papilloma              |                      X  X     X                       X                  |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +        +  +  +     +     +                 +                  |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +        +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +        +  +  +  +  +                       +               |   8        |
      Pars Distalis, Adenoma               |          X  X              X                             X               |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                          +               |   1        |
      Follicular Cell, Carcinoma           |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                         +        +           +  +        +               |   5        |
      Carcinoma                            |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Polyp Stromal                        |                X                       X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +  +  +  +  +  +        +  +  +  +  +  +  +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +                                      +               |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7|              |            |
                             DAY ON TEST   | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2|              |            |
                                           | 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |     A      |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +              +        +           +        +               |   5        |
      Adenoma                              |                                                          X               |          1 |
      Fibroadenoma                         |                            X                                             |          1 |
      Fibroadenoma, Multiple               |             X                                            X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                         +  +                    +                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                                                                  |   2        |
      Ependymoma Malignant                 | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +               |  17        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leiomyosarcoma                       |                X                                                         |          1 |
      Sarcoma                              |                                                 X                        |          1 |
      Transitional Epithelium, Carcinoma   |    X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X               |         18 |
      Transitional Epithelium, Papilloma   |                                                 X                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 8| 8| 7| 7| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    0.600%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                         +                                                |   1        |
      Polyp Adenomatous                    |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    0.600%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 5| 5| 5| 5| 4| 4| 4| 5| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |     A      |
    0.600%                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 5| 5| 5| 5| 4| 4| 4| 5| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |     A      |
    0.600%                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +                                             |   9        |
      Transitional Epithelium, Carcinoma   |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 5| 5| 6| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                 +                                                |   2        |
      Polyp Adenomatous, Multiple          |       X                 X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                 +                                                |   2        |
      Polyp Adenomatous                    |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  M  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +        +     +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +                                                                  |   1        |
      Pars Distalis, Adenoma               |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Polyp Stromal                        |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 5| 5| 6| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Carcinoma   | X  X  X     X  X  X  X  X  X                                             |          9 |
      Transitional Epithelium, Papilloma   |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2|              |            |
                                           | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hepatocellular Carcinoma             |                                                    X                     |          1 |
      Leukemia Mononuclear                 | X  X  X           X  X     X  X  X     X     X  X        X               |         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +        +                           |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                               +                 +     +                  |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                               +                 +     +                  |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                               +                 +     +                  |   3        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
      Adamantinoma Malignant               |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +                                +                           |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +                                   +                        |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +                                   +                        |   2        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +                                   +                        |   2        |
      Bilateral, Pheochromocytoma Benign   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +                    +  +     +  +     +     +                  |   7        |
      Pars Distalis, Adenoma               |          X                    X        X  X     X     X                  |          6 |
      Pars Distalis, Leukemia Mononuclear  |                                                 X                        |          1 |
      Pars Intermedia, Adenoma             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +                 +                       +     +  +               |   6        |
      Carcinoma                            |                         X                                X               |          2 |
      Bilateral, Adenoma                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                    +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X        X  X  X  X  X  X     X               |         17 |
      Interstitial Cell, Adenoma           |                               X  X                    X                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2|              |            |
                                           | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +     +     +     +     +  +  +  +  +     +                  |  13        |
      Iliac, Leukemia Mononuclear          |    X                                                                     |          1 |
      Inguinal, Fibrosarcoma               |                   X                                                      |          1 |
      Inguinal, Leukemia Mononuclear       |                   X                                                      |          1 |
      Mediastinal, Leukemia Mononuclear    | X  X  X           X                    X     X  X                        |          7 |
      Pancreatic, Leukemia Mononuclear     |    X              X           X              X  X                        |          5 |
      Renal, Leukemia Mononuclear          |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +              +                          +  +                        |   5        |
      Leukemia Mononuclear                 |    X              X                          X  X                        |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +        +     +                       +     +                        |   5        |
      Leukemia Mononuclear                 |    X              X                             X                        |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 | X  X  X           X  X     X  X  X     X     X  X        X               |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                                               |   1        |
      Thymoma Benign                       |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                                                            |   1        |
      Fibroadenoma                         |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                              +        +                  |   2        |
      Keratoacanthoma                      |                                              X        X                  |          2 |
      Squamous Cell Papilloma              |                                                       X                  |          1 |
      Subcutaneous Tissue, Fibroma         |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |
      Turbinate, Osteoma                   |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                  +  +  +        +     +                  |   5        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +        +  +                 +  +     +                        |   7        |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |          X                                                               |          1 |
      Leukemia Mononuclear                 | X                 X  X                 X        X                        |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2|              |            |
                                           | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     A      |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |    X              X                             X                        |          3 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 | X  X  X           X  X     X  X  X     X     X  X        X               |         12 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 8| 8| 8| 8| 7| 8| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
     3 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 1| 1| 0| 0| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
     6 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 4| 4| 5| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |     A      |
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     9 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 0| 5| 5| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +           +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                M                                                         |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +                                                                     |   1        |
      Pars Distalis, Adenoma               |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Interstitial Cell, Adenoma|       X           X     X                                                |          3 |
      Interstitial Cell, Adenoma           |    X        X              X                                             |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 0| 5| 5| 6| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +                                                      |   2        |
      Squamous Cell Papilloma              |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                                                                     |   1        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7|              |            |
                                           | 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
      Carcinoma                            |    X  X                                                                  |          2 |
      Polyp Adenomatous                    |             X                 X  X              X  X     X               |          6 |
      Polyp Adenomatous, Multiple          |    X     X     X  X  X  X  X        X  X                                 |          9 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
      Polyp Adenomatous                    |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +     +              +                    +                        |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +              +                    +                        |   5        |
      Squamous Cell Papilloma              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +              +                    +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                              M                           |            |
                                            __________________________________________________________________________|____________|
   Prostate                                |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                             +  +                                    |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7|              |            |
                                           | 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Transitional Epithelium, Carcinoma   |                      X        X     X              X                     |          4 |
      Transitional Epithelium, Papilloma   |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Sarcoma                              | X                                   X        X           X               |          4 |
      Squamous Cell Carcinoma              |    X     X                       X                                       |          3 |
      Squamous Cell Papilloma              |       X                                               X  X               |          3 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X               |         19 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 8| 8| 7| 7| 7| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    1.80%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
      3 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Carcinoma   |             X                                                            |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 0| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     A      |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
      6 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +           +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +                                                      |   3        |
      Polyp Adenomatous                    |       X           X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +           +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 0| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     A      |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
      6 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Sarcoma                              |             X  X                                                         |          2 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X  X  X  X  X  X                                             |         10 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                                           | 8| 3| 4| 5| 5| 7| 2| 4| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.80%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
      9 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +  +        +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +  +        +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +  +        +     +                                             |   5        |
      Carcinoma                            |          X                                                               |          1 |
      Polyp Adenomatous                    |                      X                                                   |          1 |
      Polyp Adenomatous, Multiple          |    X     X  X              X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +  +        +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                    +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                    +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                    +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                                                                     |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                                           | 8| 3| 4| 5| 5| 7| 2| 4| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.80%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
      9 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Carcinoma   |          X     X     X                                                   |          3 |
      Transitional Epithelium, Papilloma   |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Carcinoma              |                         X                                                |          1 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X  X  X  X  X  X                                             |         10 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9|                                            |            |
                                           | 0| 6| 8| 3| 9| 6| 9| 2| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +                                             |   9        |
      Carcinoma                            |                         X                                                |          1 |
      Carcinoma, Multiple                  |                   X                                                      |          1 |
      Polyp Adenomatous                    |             X  X                                                         |          2 |
      Polyp Adenomatous, Multiple          |       X  X        X  X  X  X                                             |          6 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +        +     +                                                      |   4        |
      Sarcoma, Metastatic, Urinary Bladder | X                                                                        |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Urinary Bladder                 |             X     X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +           +  +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +  +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9|                                            |            |
                                           | 0| 6| 8| 3| 9| 6| 9| 2| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Carcinoma   |                      X                                                   |          1 |
      Transitional Epithelium, Papilloma   |          X              X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Sarcoma                              | X           X              X                                             |          3 |
      Squamous Cell Carcinoma              |             X     X                                                      |          2 |
      Squamous Cell Papilloma              |             X                                                            |          1 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X  X  X  X  X  X                                             |         10 |
      Transitional Epithelium, Papilloma,  |                                                                          |            |
           Multiple                        |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8|              |            |
                                           | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
      Polyp Adenomatous, Multiple          |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
      Polyp Adenomatous                    |                         X              X  X  X           X               |          5 |
      Polyp Adenomatous, Multiple          |    X  X        X                 X  X           X  X                     |          7 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
      Polyp Adenomatous                    |       X                    X     X                                       |          3 |
      Polyp Adenomatous, Multiple          |                   X                          X                           |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                            X                       X                     |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +  +                                                |   2        |
      Mesothelioma Malignant               |                      X  X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                      +     +                          +  +               |   4        |
      Mesothelioma Malignant               |                      X                                                   |          1 |
      Acinar Cell, Adenoma                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +     +                    +     +     +     +  +               |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +     +                    +     +     +     +  +               |   9        |
      Squamous Cell Papilloma              |                                           X                              |          1 |
      Squamous Cell Papilloma, Multiple    |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +     +                    +     +     +     +  +               |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +                                               +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                            +                             +               |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                            +                             +               |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                            +                             +               |   2        |
      Pheochromocytoma Benign              |                            X                             X               |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                       +  +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8|              |            |
                                           | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Mesothelioma Malignant               |                      X  X              X  X                              |          4 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +              +  +                 +     +                     |   6        |
      Adenoma                              |                                              X                           |          1 |
      Carcinoma                            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Bilateral, Interstitial Cell, Adenoma|       X     X     X     X                    X        X  X               |          7 |
      Interstitial Cell, Adenoma           |    X     X           X     X        X  X  X     X  X                     |          9 |
      Tunic, Mesothelioma Malignant        |                      X  X              X  X                              |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +  +  +     +     +  +  +  +  +  +  +  +                  |  14        |
      Mediastinal, Leukemia Mononuclear    |                            X                                             |          1 |
      Pancreatic, Leukemia Mononuclear     |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +  +           +           +  +  +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +           +        +        +  +  +                     |   8        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                            X                       X                     |          2 |
      Mesothelioma Malignant               |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |   1        |
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |            |
           Multiple                        | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                        +                                 |   1        |
      Mesothelioma Malignant               |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                            +                                             |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8|              |            |
                                           | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Nephroblastoma                       |                               X                                          |          1 |
      Renal Tubule, Oncocytoma Benign      |          X                                                               |          1 |
      Transitional Epithelium, Carcinoma   |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                 +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Mesothelioma Malignant               |                      X  X                                                |          2 |
      Transitional Epithelium, Carcinoma   | X  X  X  X  X     X  X  X        X  X  X     X  X  X  X  X               |         16 |
      Transitional Epithelium, Papilloma   |                                           X                              |          1 |
      Transitional Epithelium, Papilloma,  |                                                                          |            |
           Multiple                        |                X           X                                             |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Leukemia Mononuclear                 |                            X                       X                     |          2 |
      Mesothelioma Malignant               |                      X  X              X  X                              |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 8| 8| 8| 8| 7| 7| 7| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |     A      |
    0.600%                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 1| 1| 0| 0| 0| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +                                                            |   2        |
      Squamous Cell Papilloma              |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +           +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 1| 1| 0| 0| 0| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Papilloma   |       X              X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 5| 5| 5| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.600%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +     +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +                                                   |   2        |
      Polyp Adenomatous                    |                X                                                         |          1 |
      Polyp Adenomatous, Multiple          |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 5| 5| 5| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.600%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Carcinoma   |       X           X  X                                                   |          3 |
      Transitional Epithelium, Papilloma   | X                          X                                             |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5|                                            |            |
                                           | 5| 4| 4| 8| 6| 9| 9| 0| 5| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +                                             |   9        |
      Polyp Adenomatous                    | X                 X  X     X                                             |          4 |
      Polyp Adenomatous, Multiple          |    X  X     X  X        X                                                |          5 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +                                             |   9        |
      Polyp Adenomatous                    |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                                                                  |   1        |
      Squamous Cell Papilloma              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mesothelioma Malignant               |             X              X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Interstitial Cell, Adenoma|          X  X        X  X  X                                             |          5 |
      Interstitial Cell, Adenoma           |       X           X                                                      |          2 |
      Tunic, Mesothelioma Malignant        |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +     +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +     +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05092-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 13:30:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5|                                            |            |
                                           | 5| 4| 4| 8| 6| 9| 9| 0| 5| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  M  +  +  +  M  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Sarcoma                              | X           X                                                            |          2 |
      Transitional Epithelium, Carcinoma   | X  X  X  X     X  X  X  X                                                |          8 |
      Transitional Epithelium, Papilloma   |             X              X                                             |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mesothelioma Malignant               |             X              X                                             |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------