TDMS Study 05092-03 Pathology Tables
NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 Facility: Southern Research Institute Chemical CAS #: 0091-23-6 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| | | DAY ON TEST | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2| | | | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A | 0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A | 1 | __________________________________________________________________________|____________| Intestine Small | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Pancreas | + | 1 | __________________________________________________________________________|____________| Stomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | Leukemia Mononuclear | X | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + | 2 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + | 2 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + | 12 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 12 | __________________________________________________________________________|____________| Thyroid Gland | + | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| | | DAY ON TEST | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2| | | | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A | 0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + | 3 | Adenoma | X | 1 | Carcinoma | X X | 2 | __________________________________________________________________________|____________| Ovary | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + M + + | 19 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + | 14 | Deep Cervical, Leukemia Mononuclear | X | 1 | Iliac, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X | 2 | Pancreatic, Leukemia Mononuclear | X X X | 3 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + | 7 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 2 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Thymus | + | 1 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + | 13 | Fibroadenoma | X X X X X X | 6 | Fibroadenoma, Multiple | X | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + | 1 | Head, Squamous Cell Carcinoma, Deep | | | Invasion | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | Glioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| | | DAY ON TEST | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2| | | | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A | 0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Ureter | + + + + + M + + + + M + + + + + + + + + | 18 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + M + + + + + M + | 18 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 7| 7| 8| 8| 8| 7| 7| 7| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 0| 0| 1| 0| 0| 0| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Mesentery | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | | 4| 4| 4| 5| 5| 4| 4| 5| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5| | | | 5| 5| 5| 6| 6| 8| 3| 5| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + | 2 | Adenoma | X | 1 | __________________________________________________________________________|____________| Ovary | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 1 | Fibroadenoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Hindlimb, Rhabdomyosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5| | | | 5| 5| 5| 6| 6| 8| 3| 5| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | M + + + + + + + + + | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3| | | DAY ON TEST | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0| | | | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | Polyp Adenomatous | X X | 2 | Polyp Adenomatous, Multiple | X X X X X X X | 7 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 20 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Mesentery | + + | 2 | Sarcoma, Multiple, Metastatic, | | | Urinary Bladder | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + | 3 | Sarcoma, Metastatic, Urinary Bladder | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + | 7 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + | 7 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | Squamous Cell Papilloma | X X X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + | 7 | Serosa, Sarcoma, Metastatic, Urinary | | | Bladder | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3| | | DAY ON TEST | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0| | | | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + | 1 | __________________________________________________________________________|____________| Ovary | + | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 20 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | Cervix, Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + | 5 | Iliac, Squamous Cell Carcinoma, | | | Metastatic, Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 20 | Capsule, Squamous Cell Carcinoma, | | | Metastatic, Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Thymus | + | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3| | | DAY ON TEST | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0| | | | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 20 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | Transitional Epithelium, Carcinoma | X | 1 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + M + + + + + + + + + | 19 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 | Leiomyosarcoma | X | 1 | Sarcoma | X X X X X X | 6 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | X | 1 | Transitional Epithelium, Carcinoma | X X X X X X X X X X X X X X X X X X X | 19 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1.80% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Transitional Epithelium, Carcinoma | X X X X X X X X X X | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7| | | | 4| 4| 5| 5| 5| 3| 5| 7| 2| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1.80% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + | 3 | Polyp Adenomatous, Multiple | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach | + | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7| | | | 4| 4| 5| 5| 5| 3| 5| 7| 2| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1.80% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Sarcoma | X X X | 3 | Transitional Epithelium, Carcinoma | X X X X X X X X X X | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 0| 2| 2| 3| 3| | | DAY ON TEST | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3| | | | 5| 7| 5| 5| 6| 4| 1| 8| 9| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 9 | Carcinoma | X X | 2 | Polyp Adenomatous | X X X | 3 | Polyp Adenomatous, Multiple | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Cervix, Leiomyosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 0| 2| 2| 3| 3| | | DAY ON TEST | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3| | | | 5| 7| 5| 5| 6| 4| 1| 8| 9| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A | 1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Fibrosarcoma | X | 1 | Leiomyosarcoma | X | 1 | Sarcoma | X X | 2 | Squamous Cell Papilloma | X | 1 | Squamous Cell Papilloma, Multiple | X X | 2 | Transitional Epithelium, Carcinoma | X X X X X X X X X | 9 | Transitional Epithelium, Papilloma, | | | Multiple | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7| | | DAY ON TEST | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2| | | | 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | Polyp Adenomatous | X X X | 3 | Polyp Adenomatous, Multiple | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | Polyp Adenomatous, Multiple | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 9 | Squamous Cell Papilloma | X X X X | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | Pars Distalis, Adenoma | X X X X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 5 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + | 20 | Polyp Stromal | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7| | | DAY ON TEST | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2| | | | 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | Adenoma | X | 1 | Fibroadenoma | X | 1 | Fibroadenoma, Multiple | X X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + | 2 | Ependymoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________|____________| Ureter | + + + M M + M + + + + + + + + + + + + + | 17 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 | Leiomyosarcoma | X | 1 | Sarcoma | X | 1 | Transitional Epithelium, Carcinoma | X X X X X X X X X X X X X X X X X X | 18 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 7| 7| 7| 8| 8| 7| 7| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0.600% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + | 1 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 0.600% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | | 4| 5| 5| 5| 5| 4| 4| 4| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A | 0.600% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Stomach | + | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | | 4| 5| 5| 5| 5| 4| 4| 4| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A | 0.600% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + M + + + + + + | 9 | Transitional Epithelium, Carcinoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 6| 6| 5| 5| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + | 2 | Polyp Adenomatous, Multiple | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + | 2 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Liver | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Mesentery | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + | 1 | Pars Distalis, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + | 1 | __________________________________________________________________________|____________| Oviduct | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 6| 6| 5| 5| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A | 0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Transitional Epithelium, Carcinoma | X X X X X X X X X | 9 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2| | | | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 20 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 12 | __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Pancreas | + | 1 | __________________________________________________________________________|____________| Stomach | + + + | 3 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + | 3 | __________________________________________________________________________|____________| Tooth | + | 1 | Adamantinoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + | 2 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + | 2 | Bilateral, Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + | 7 | Pars Distalis, Adenoma | X X X X X X | 6 | Pars Distalis, Leukemia Mononuclear | X | 1 | Pars Intermedia, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 6 | Carcinoma | X X | 2 | Bilateral, Adenoma | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 20 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | 17 | Interstitial Cell, Adenoma | X X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2| | | | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + | 13 | Iliac, Leukemia Mononuclear | X | 1 | Inguinal, Fibrosarcoma | X | 1 | Inguinal, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X X X X X X | 7 | Pancreatic, Leukemia Mononuclear | X X X X X | 5 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | Leukemia Mononuclear | X X X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X X X X X X X X X X X | 12 | __________________________________________________________________________|____________| Thymus | + | 1 | Thymoma Benign | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 1 | Fibroadenoma | X | 1 | __________________________________________________________________________|____________| Skin | + + | 2 | Keratoacanthoma | X X | 2 | Squamous Cell Papilloma | X | 1 | Subcutaneous Tissue, Fibroma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 1 | Turbinate, Osteoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + | 7 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Leukemia Mononuclear | X X X X X | 5 | __________________________________________________________________________|____________| Nose | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2| | | | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Ureter | + M + + + + + + + + + + M + + + + + + + | 18 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X X X X X X X X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 7| 8| 8| 8| 8| 7| 8| 8| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + M + + + + | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + M + + + + | 9 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 0| 1| 1| 0| 0| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | | 4| 4| 4| 5| 5| 4| 4| 4| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A | 0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Mesentery | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | | 5| 5| 5| 6| 6| 0| 5| 5| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 1 | __________________________________________________________________________|____________| Intestine Small | + | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Stomach | + | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 1 | __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | M | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + | 1 | Pars Distalis, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Bilateral, Interstitial Cell, Adenoma| X X X | 3 | Interstitial Cell, Adenoma | X X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | | 5| 5| 5| 6| 6| 0| 5| 5| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + | 2 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 1 | Alveolar/Bronchiolar Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7| | | | 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + | 18 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 18 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 18 | Carcinoma | X X | 2 | Polyp Adenomatous | X X X X X X | 6 | Polyp Adenomatous, Multiple | X X X X X X X X X | 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 18 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Intestine Small | + | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________|____________| Mesentery | + | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________|____________| Penis | M | | __________________________________________________________________________|____________| Prostate | + | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 20 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7| | | | 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 20 | Transitional Epithelium, Carcinoma | X X X X | 4 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________|____________| Urethra | + | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 | Sarcoma | X X X X | 4 | Squamous Cell Carcinoma | X X X | 3 | Squamous Cell Papilloma | X X X | 3 | Transitional Epithelium, Carcinoma | X X X X X X X X X X X X X X X X X X X | 19 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 7| 7| 7| 8| 8| 7| 7| 7| 8| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1.80% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | 3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Transitional Epithelium, Carcinoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 1| 1| 1| 0| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A | 1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + | 3 | Polyp Adenomatous | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 1| 1| 1| 0| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A | 1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | M + + + + + + + + + | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Sarcoma | X X | 2 | Transitional Epithelium, Carcinoma | X X X X X X X X X X | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| | | | 8| 3| 4| 5| 5| 7| 2| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.80% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | Carcinoma | X | 1 | Polyp Adenomatous | X | 1 | Polyp Adenomatous, Multiple | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach | + + | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| | | | 8| 3| 4| 5| 5| 7| 2| 4| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.80% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar/Bronchiolar Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Transitional Epithelium, Carcinoma | X X X | 3 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Squamous Cell Carcinoma | X | 1 | Transitional Epithelium, Carcinoma | X X X X X X X X X X | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9| | | | 0| 6| 8| 3| 9| 6| 9| 2| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 9 | Carcinoma | X | 1 | Carcinoma, Multiple | X | 1 | Polyp Adenomatous | X X | 2 | Polyp Adenomatous, Multiple | X X X X X X | 6 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Prostate | + + + + | 4 | Sarcoma, Metastatic, Urinary Bladder | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Urinary Bladder | X X | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9| | | | 0| 6| 8| 3| 9| 6| 9| 2| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Transitional Epithelium, Carcinoma | X | 1 | Transitional Epithelium, Papilloma | X X | 2 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Sarcoma | X X X | 3 | Squamous Cell Carcinoma | X X | 2 | Squamous Cell Papilloma | X | 1 | Transitional Epithelium, Carcinoma | X X X X X X X X X X | 10 | Transitional Epithelium, Papilloma, | | | Multiple | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6| | | DAY ON TEST | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8| | | | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 | Polyp Adenomatous, Multiple | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 | Polyp Adenomatous | X X X X X | 5 | Polyp Adenomatous, Multiple | X X X X X X X | 7 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | Polyp Adenomatous | X X X | 3 | Polyp Adenomatous, Multiple | X X | 2 | __________________________________________________________________________|____________| Intestine Small | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Mesentery | + + | 2 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + | 4 | Mesothelioma Malignant | X | 1 | Acinar Cell, Adenoma | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 9 | Squamous Cell Papilloma | X | 1 | Squamous Cell Papilloma, Multiple | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + | 2 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + | 2 | Pheochromocytoma Benign | X X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6| | | DAY ON TEST | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8| | | | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 | Mesothelioma Malignant | X X X X | 4 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 6 | Adenoma | X | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Prostate | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + | 20 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | 7 | Interstitial Cell, Adenoma | X X X X X X X X X | 9 | Tunic, Mesothelioma Malignant | X X X X | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + | 14 | Mediastinal, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 8 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + | 20 | Hemangiosarcoma | X | 1 | Leukemia Mononuclear | X X | 2 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 1 | __________________________________________________________________________|____________| Skin | + | 1 | Subcutaneous Tissue, Hemangiosarcoma,| | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6| | | DAY ON TEST | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8| | | | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + | 20 | Nephroblastoma | X | 1 | Renal Tubule, Oncocytoma Benign | X | 1 | Transitional Epithelium, Carcinoma | X | 1 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + + + + + + + + + + + | 20 | __________________________________________________________________________|____________| Urethra | + + | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 | Mesothelioma Malignant | X X | 2 | Transitional Epithelium, Carcinoma | X X X X X X X X X X X X X X X X | 16 | Transitional Epithelium, Papilloma | X | 1 | Transitional Epithelium, Papilloma, | | | Multiple | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 | Leukemia Mononuclear | X X | 2 | Mesothelioma Malignant | X X X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 7| 8| 8| 8| 8| 7| 7| 7| 7| 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A | 0.600% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + M + + | 9 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 0| 1| 1| 0| 0| 0| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach | + + | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + | 2 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 0| 0| 0| 1| 1| 0| 0| 0| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | 6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Transitional Epithelium, Papilloma | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | | 4| 4| 4| 5| 5| 4| 5| 5| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.600% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + | 2 | Polyp Adenomatous | X | 1 | Polyp Adenomatous, Multiple | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | | 4| 4| 4| 5| 5| 4| 5| 5| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.600% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | 9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Transitional Epithelium, Carcinoma | X X X | 3 | Transitional Epithelium, Papilloma | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| | | DAY ON TEST | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5| | | | 5| 4| 4| 8| 6| 9| 9| 0| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 9 | Polyp Adenomatous | X X X X | 4 | Polyp Adenomatous, Multiple | X X X X X | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 9 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Stomach | + | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________|____________| Prostate | + + + | 3 | __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Bilateral, Interstitial Cell, Adenoma| X X X X X | 5 | Interstitial Cell, Adenoma | X X | 2 | Tunic, Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05092-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/08/97 Route: DOSED FEED Time: 13:30:04 __________________________________________________________________________________________________________________________________ | 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| | | DAY ON TEST | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5| | | | 5| 4| 4| 8| 6| 9| 9| 0| 5| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | 15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Ureter | + + + M + + + M + + | 8 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Sarcoma | X X | 2 | Transitional Epithelium, Carcinoma | X X X X X X X X | 8 | Transitional Epithelium, Papilloma | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------