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https://ntp.niehs.nih.gov/go/969

TDMS Study 05092-03 Pathology Tables

NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 07:37:22




       Facility:  Southern Research Institute

       Chemical CAS #:  0091-23-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2|              |            |
                                           | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      A     |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +        A                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +        A                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +        A                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +        A                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Basophilic Focus                     |                                                    1                     |      1  1.0|
      Basophilic Focus, Multiple           |          2  2     2  2  2  2  2  2  2  2  2     2     2  2               |     14  2.0|
      Eosinophilic Focus                   |          1           1           3                       2               |      4  1.8|
      Eosinophilic Focus, Multiple         |                            2                                             |      1  2.0|
      Hepatodiaphragmatic Nodule           |          2              2                                                |      2  2.0|
      Inflammation, Granulomatous, Multiple| 1        1        1  2  2        1  2  1  2  1  2  2  1  2               |     14  1.5|
      Mixed Cell Focus                     |                         2  2        3     3                              |      4  2.5|
      Vacuolization Cytoplasmic            |    3  4                                      3                           |      3  3.3|
      Bile Duct, Hyperplasia               |       2           1     2                 1     1                        |      5  1.4|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     |    2  2        1  2     1                    2     1  1                  |      8  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   1        |
      Fat, Necrosis, Focal                 |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +              +                       +     +                     |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +              +                       +     +                     |   5        |
      Diverticulum                         |                                                    2                     |      1  2.0|
      Edema                                |    3                                                                     |      1  3.0|
      Ulcer                                |                                              2                           |      1  2.0|
      Epithelium, Hyperplasia              |    3                                         3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +              +                       +     +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +                                                                  |   2        |
      Bilateral, Vacuolization Cytoplasmic |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +                                                                  |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   2                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2|              |            |
                                           | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      A     |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +     +  +  +  +  +           +  +                     |  12        |
      Pars Distalis, Hemorrhage            |    4              3           4                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             +                                      +     +               |   3        |
      Inflammation, Suppurative            |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |   1        |
      Cyst                                 | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  19        |
      Dilatation                           |                   3                 2                                    |      2  2.5|
      Fibrosis, Focal                      |                               2                                          |      1  2.0|
      Inflammation, Suppurative            |             2     2                                                      |      2  2.0|
      Cervix, Cyst                         |                   3                                                      |      1  3.0|
      Cervix, Myometrium, Hypertrophy      |                                              3                           |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |             1     3                    2                                 |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +        +  +  +  +  +  +  +  +  +     +     +                  |  14        |
      Deep Cervical, Angiectasis           |                                     3                                    |      1  3.0|
      Mediastinal, Angiectasis             |                                     2  2                                 |      2  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                       2                  |      1  2.0|
      Mediastinal, Pigmentation            |                   2        3     2                                       |      3  2.3|
      Pancreatic, Angiectasis              |                      4                          2                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +              +  +  +  +        +  +                              |   7        |
      Cyst                                 |                            2                                             |      1  2.0|
      Cyst, Multiple                       |                                           2                              |      1  2.0|
      Hyperplasia, Lymphoid                |                      3                    2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           | 2           2     3        2     2     3  2     2  2  2  2               |     11  2.2|
      Depletion Lymphoid                   | 1              3  2                    1                                 |      4  1.8|
      Hematopoietic Cell Proliferation     | 2        2  2     2  2  2  2  2  3     2  3     2  2  2  2               |     15  2.1|
      Hyperplasia, Histiocytic, Lymphoid   |                         3                                                |      1  3.0|
      Pigmentation                         | 3        3  3  3  2  2     3  3  2  3  2     3  3  3  2                  |     15  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   3                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2|              |            |
                                           | 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      A     |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +        +  +  +  +  +  +  +        +     +                  |  13        |
      Hyperplasia, Lobular                 |       2  3  2        3  3  3     2                    2                  |      8  2.5|
      Duct, Cyst                           |    3  2  3              2     3  2  3           3     2                  |      9  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                                      +                           |   2        |
      Calvarium, Hyperostosis              |       2                                      2                           |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                       +     +                                    |   5        |
      Compression                          |    2  3                       3     2                                    |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +                                      +                  |   2        |
      Congestion                           |                3                                                         |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   1        |
      Cataract                             |                                  3                                       |      1  3.0|
      Retina, Degeneration                 |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Nephropathy, Chronic                 |    2  2  2  2     1  1  1  3  2  1  2  2  1  1  2  1  2  2               |     18  1.7|
      Pelvis, Mineralization               | 1           1  1  1                       1                              |      5  1.0|
      Renal Tubule, Mineralization         | 1  2     1  2  1  1     1  1     1  1  1  1  1  1  1  1  1               |     17  1.1|
      Renal Tubule, Pigmentation           |    1  2  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1               |     18  1.1|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +               |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   4                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 8| 8| 8| 7| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     3 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |                2                                                         |      1  2.0|
      Vacuolization Cytoplasmic            |       2                                                                  |      1  2.0|
      Hepatocyte, Necrosis, Multifocal     |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pigmentation                         | 2  2  2  2  2  2  2  2  1  2                                             |     10  1.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Corticomedullary Junction,           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 8| 8| 8| 7| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     3 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Mineralization                   | 1  2     2  2  1  2  1  2  2                                             |      9  1.7|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 0| 1| 0| 0| 0| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
     6 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                   1                                                      |      1  1.0|
      Inflammation, Granulomatous, Multiple| 2     1        2     2                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   1        |
      Fat, Necrosis, Focal                 |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pigmentation                         | 3  2  3  3  3                                                            |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 0| 1| 0| 0| 0| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
     6 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Corticomedullary Junction,           |                                                                          |            |
          Mineralization                   |          2  2                                                            |      2  2.0|
      Renal Tubule, Mineralization         |    1  3                 2                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 4| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     9 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     | 1        1  1  1  1                                                      |      5  1.0|
      Inflammation, Granulomatous, Multiple|          1  1  1  1        1                                             |      5  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +                                                                     |   1        |
      Cyst                                 |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2     2  2                                                               |      3  2.0|
      Hematopoietic Cell Proliferation     |       2                                                                  |      1  2.0|
      Pigmentation                         | 3  2  3  2              3                                                |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 4| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     9 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 |       1     1     1  1  1                                                |      5  1.0|
      Pelvis, Mineralization               |    1                                                                     |      1  1.0|
      Renal Tubule, Mineralization         |    1  1  1  1  1  1  1  2  2                                             |      9  1.2|
      Renal Tubule, Pigmentation           |          1     1  1  1  1  1                                             |      6  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 8| 3| 5| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus, Multiple           | 2        1  1     1  1  1  1                                             |      7  1.1|
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
      Inflammation, Granulomatous, Multiple|    1              1                                                      |      2  1.0|
      Bile Duct, Hyperplasia               |       1     1                                                            |      2  1.0|
      Hepatocyte, Hypertrophy              |                2  1     1                                                |      3  1.3|
      Hepatocyte, Mitotic Alteration       |                3                                                         |      1  3.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +  +                                             |   2        |
      Fat, Necrosis, Focal                 |                         2  3                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             +        +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                         +                                                |   1        |
      Cyst                                 |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           |                   1        2                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2  2  2  2        2                                                      |      5  2.0|
      Hematopoietic Cell Proliferation     | 2  2           4  2                                                      |      4  2.5|
      Pigmentation                         | 3  2  2  2        2  3                                                   |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 8| 3| 5| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 |    1  1           1  1  1  1                                             |      6  1.0|
      Pelvis, Mineralization               |                1     1                                                   |      2  1.0|
      Renal Tubule, Mineralization         | 1  1  1  2  2        2  2  1                                             |      8  1.5|
      Renal Tubule, Pigmentation           |    1  1  1  1  1  1  1  1  1                                             |      9  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3|              |            |
                             DAY ON TEST   | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0|              |            |
                                           | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +  +     +     +              +  +     +     +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +  +     +     +              +  +     +     +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +  +     +     +              +  +     +     +               |  10        |
      Parasite Metazoan                    |                                                    2                     |      1  2.0|
      Epithelium, Hyperplasia              |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +  +     +     +              +  +     +     +               |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hepatodiaphragmatic Nodule           |                                        2                                 |      1  2.0|
      Inflammation, Granulomatous, Multiple| 2  2  1     2     1  2           2  2  2  2  2  2  2  2  1               |     15  1.8|
      Bile Duct, Hyperplasia               |       2                                                                  |      1  2.0|
      Hepatocyte, Hypertrophy              |                                     1                                    |      1  1.0|
      Hepatocyte, Necrosis, Multifocal     |                               1                                          |      1  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  2  2  2  1  1  2  2  1  2  2  2  2  2  2  2  2  2  2  1               |     20  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +                                               +                  |   3        |
      Ectopic Tissue                       |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +     +     +  +     +              +                              |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +     +  +     +              +                              |   7        |
      Epithelium, Hyperplasia              |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +     +  +     +              +                              |   7        |
      Mineralization                       |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                            +                                             |   1        |
      Duct, Cyst                           |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3|              |            |
                             DAY ON TEST   | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0|              |            |
                                           | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              | 2  4  3  3  4  3  3  4  2  4  4  3  2  3  3  2  4  3  3  4               |     20  3.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +              +           +           +                           |   5        |
      Iliac, Hyperplasia, Lymphoid         | 3                    2           4           3                           |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           |       3  1  1  2  2  3     1  2  2  2  2  2  2  4  2  2  2               |     17  2.1|
      Depletion Lymphoid                   |    3           3  3     3     3     1     3     1                        |      8  2.5|
      Hematopoietic Cell Proliferation     | 3     3  2  3        2  3  3  2  3  3        2  2  3  2  2               |     15  2.5|
      Hyperplasia, Lymphoid                |             3                                                            |      1  3.0|
      Pigmentation                         |          2                    3  1  2  2  2     2        2               |      8  2.0|
      Capsule, Hypertrophy                 | 3  2  2  2  2  2  2  2  2  2  1  2  2  3  2  3  3  2  2  2               |     20  2.2|
      Capsule, Inflammation, Chronic       | 3  2  2  2  2  2     2     2     2  2  3  2  2  2  1  2  2               |     17  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +                 +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hydronephrosis                       | 2  3  4     4                    3  4  4     2  3  4     2               |     11  3.2|
      Nephropathy, Chronic                 |                            1                 1                           |      2  1.0|
      Bilateral, Hydronephrosis            |          4           1                                3                  |      3  2.7|
      Papilla, Necrosis                    |                                                       3                  |      1  3.0|
      Pelvis, Dilatation                   |                         2  3                                             |      2  2.5|
      Pelvis, Mineralization               | 1              1  1           1     1     2  1  1                        |      8  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3|              |            |
                             DAY ON TEST   | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0|              |            |
                                           | 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Necrosis                     |                                                    2                     |      1  2.0|
      Renal Tubule, Mineralization         |                   2  1        1     2  1  2     1     1  1               |      9  1.3|
      Renal Tubule, Pigmentation           | 2  2  3  2  2  2  2  2  1  2  1  3  3  2  2  2  3  2  2  2               |     20  2.1|
      Renal Tubule, Regeneration           |                                                 3  3                     |      2  3.0|
      Transitional Epithelium, Hyperplasia | 2  4           2  3              2        2  3        2  2               |      9  2.4|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |  19        |
      Dilatation                           | 2  2  3  4  3        2     2     2  4  4     2  2  2  3  2               |     15  2.6|
      Transitional Epithelium, Hyperplasia | 2                                            3                           |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hemorrhage                           | 3                                               4                        |      2  3.5|
      Inflammation, Subacute               |                      3                                                   |      1  3.0|
      Inflammation, Suppurative            |                            3        3           3  4     3               |      5  3.2|
      Metaplasia, Squamous                 | 3  4  3     3     2  3           3  4  3  2  3  2  2                     |     13  2.8|
      Necrosis                             |                                                       4                  |      1  4.0|
      Transitional Epithelium, Hyperplasia |                               2                                          |      1  2.0|
      Wall, Infiltration Cellular, Lipocyte|          3                 3                                             |      2  3.0|
      Wall, Proliferation Connective Tissue| 3     4  4  4     2  3     3     2  4  3        3  4  4  3               |     14  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           | 2                                                                        |      1  2.0|
      Vacuolization Cytoplasmic            |                            3                                             |      1  3.0|
      Hepatocyte, Hypertrophy              | 2  3  2  2  2  2  2  2  1  2                                             |     10  2.0|
      Hepatocyte, Necrosis, Multifocal     | 2  1  2  1  1  1  2  1  1  1                                             |     10  1.3|
      Hepatocyte, Vacuolization Cytoplasmic|    1                                                                     |      1  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |                         1                                                |      1  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  2  3  2  2  2  2  2  2  3                                             |     10  2.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 4  4  4  4  4  4  4  4  3  4                                             |     10  3.9|
      Depletion Lymphoid                   | 2  2  3  3  3  3  3  3  3  3                                             |     10  2.8|
      Pigmentation                         | 2  3  2  3  2  3  3  2  3  3                                             |     10  2.6|
      Capsule, Hypertrophy                 | 2  2  3  2  2  2  2  2  3  2                                             |     10  2.2|
      Capsule, Inflammation, Chronic       | 2  2     3  2  3  3  2  3  3                                             |      9  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Corticomedullary Junction,           |                                                                          |            |
          Mineralization                   | 2     1  2  2  1  1  1  1  2                                             |      9  1.4|
      Renal Tubule, Pigmentation           | 3  3  3  4  3  3  3  4  3  3                                             |     10  3.2|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Subacute               |    2     3  2  3  3  2  2  2                                             |      8  2.4|
      Metaplasia, Squamous                 | 3  2  3  3  2  4  3  4  2  3                                             |     10  2.9|
      Transitional Epithelium, Hyperplasia | 3  3  4  4  3  4  4  4  4  4                                             |     10  3.7|
      Wall, Proliferation Connective Tissue|          3     2  2  2  2  2                                             |      6  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    1.80%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous, Multiple| 2     2  2     2     2                                                   |      5  2.0|
      Hepatocyte, Hypertrophy              | 3  3  2  3  3  2  2  2  2  2                                             |     10  2.4|
      Hepatocyte, Necrosis, Multifocal     | 2  2  1  2  2  2  2  2  2  2                                             |     10  1.9|
      Hepatocyte, Vacuolization Cytoplasmic| 2                                                                        |      1  2.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2  2  2  4  3  3  2  4  2  4                                             |     10  2.8|
      Depletion Lymphoid                   | 3  2  3  2  3  3  3  2  3  3                                             |     10  2.7|
      Pigmentation                         | 2  2  2     2  2  2  2  2  2                                             |      9  2.0|
      Capsule, Hypertrophy                 | 2  2  3  3  3  3  3  3  3  3                                             |     10  2.8|
      Capsule, Inflammation, Chronic       | 2  2  3  3  3  3  2  3  2  3                                             |     10  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    1.80%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Corticomedullary Junction,           |                                                                          |            |
          Mineralization                   |    2           1                                                         |      2  1.5|
      Renal Tubule, Pigmentation           | 3  3  3  3  4  3  3  4  4  3                                             |     10  3.3|
      Transitional Epithelium, Hyperplasia |          4        2                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Subacute               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
      Metaplasia, Squamous                 | 4  3  4  4  4  4  2  4  4  4                                             |     10  3.7|
      Wall, Proliferation Connective Tissue| 3  2  3  3  3  2  2  3  3  2                                             |     10  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7|                                            |            |
                                           | 4| 4| 5| 5| 5| 3| 5| 7| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    1.80%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +     +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +              +     +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              +     +                                                   |   3        |
      Parasite Metazoan                    | 2                                                                        |      1  2.0|
      Epithelium, Hyperplasia              |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +     +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |             2                                                            |      1  2.0|
      Inflammation, Granulomatous, Multiple| 2  2  3  2  2  1  2  1  2  2                                             |     10  1.9|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2  2     2     4  2  2  2                                                |      7  2.3|
      Dilatation                           |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +        +                                                |   3        |
      Pancreatic, Hyperplasia, Lymphoid    | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                   3                                                      |      1  3.0|
      Congestion                           |    3  2  2  2  1           3                                             |      6  2.2|
      Depletion Lymphoid                   |                3        2                                                |      2  2.5|
      Hematopoietic Cell Proliferation     | 3  2  2  3  2        3                                                   |      6  2.5|
      Pigmentation                         |    2     2  2  2  2     2  2                                             |      7  2.0|
      Capsule, Hypertrophy                 | 3  2  2  2  2  3  3  2  3  2                                             |     10  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7|                                            |            |
                                           | 4| 4| 5| 5| 5| 3| 5| 7| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    1.80%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Inflammation, Chronic       | 3  2  2  2  2  3  1  2  1  1                                             |     10  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +                                                      |   2        |
      Atrophy                              |                   3                                                      |      1  3.0|
      Congestion                           |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydronephrosis                       |                         3                                                |      1  3.0|
      Nephropathy, Chronic                 | 1     1                 3  1                                             |      4  1.5|
      Papilla, Necrosis                    |                4                                                         |      1  4.0|
      Pelvis, Mineralization               |    1  1        1                                                         |      3  1.0|
      Renal Tubule, Mineralization         |    1     1  1  3  2  1     2                                             |      7  1.6|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  3  3  3  2  2                                             |     10  2.3|
      Transitional Epithelium, Hyperplasia |       2        2  3                                                      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           | 2                       3  2                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Inflammation, Subacute               |    2                                                                     |      1  2.0|
      Inflammation, Suppurative            |          3  3           2                                                |      3  2.7|
      Metaplasia, Squamous                 | 3        3  2  4  4  2  4  2                                             |      8  3.0|
      Wall, Proliferation Connective Tissue| 2  3     3  2           3                                                |      5  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 0| 2| 2| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3|                                            |            |
                                           | 5| 7| 5| 5| 6| 4| 1| 8| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +                                             |   9        |
      Ulcer                                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +                                             |   9        |
      Autolysis                            | 1                                                                        |      1  1.0|
      Intussusception                      |                         X                                                |      1     |
      Necrosis                             |                         2                                                |      1  2.0|
      Proliferation Connective Tissue      |    4                                                                     |      1  4.0|
      Epithelium, Hyperplasia              |                   3  2  2                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +                                             |   9        |
      Autolysis                            | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |                         2                                                |      1  2.0|
      Inflammation, Granulomatous, Multiple| 2  2  2  1  2     1  2  2  2                                             |      9  1.8|
      Hepatocyte, Hypertrophy              |                         1                                                |      1  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 1  2  1  1  1  2  2  2  2  2                                             |     10  1.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                            +                                             |   1        |
      Acinus, Atrophy                      |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    3  4        4     4                                                   |      4  3.8|
      Dilatation                           |          4  1                                                            |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +     +  +                                                   |   5        |
      Iliac, Hyperplasia, Lymphoid         |       3  3           3                                                   |      3  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +                                                            |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 0| 2| 2| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3|                                            |            |
                                           | 5| 7| 5| 5| 6| 4| 1| 8| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |    2     2  2  4     3  2                                                |      6  2.5|
      Depletion Lymphoid                   | 1  2           3  2     3  1                                             |      6  2.0|
      Hematopoietic Cell Proliferation     |       3  2  2        2                                                   |      4  2.3|
      Pigmentation                         | 2  2           3        2                                                |      4  2.3|
      Capsule, Hypertrophy                 | 3  3  2  2  2     3  3  3  2                                             |      9  2.6|
      Capsule, Inflammation, Chronic       | 3  2  2  2  3     3  2  3  2                                             |      9  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
      Cornea, Edema                        | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydronephrosis                       | 3                 2  2                                                   |      3  2.3|
      Pelvis, Mineralization               |    1  1     1        1                                                   |      4  1.0|
      Pelvis, Necrosis                     | 2                                                                        |      1  2.0|
      Renal Tubule, Mineralization         | 1     2        1     1     1                                             |      5  1.2|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  1  2  2  2  2                                             |     10  1.9|
      Renal Tubule, Regeneration           |       3                                                                  |      1  3.0|
      Transitional Epithelium, Hyperplasia | 2     3     2        2  1                                                |      5  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           | 3                 2  3                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |       3                 4                                                |      2  3.5|
      Inflammation, Suppurative            | 3                    3                                                   |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 3| 3| 3| 0| 2| 2| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3|                                            |            |
                                           | 5| 7| 5| 5| 6| 4| 1| 8| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Squamous                 | 3     2  4  3     4  4  4  4                                             |      8  3.5|
      Wall, Proliferation Connective Tissue| 3  2        2     4  4                                                   |      5  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7|              |            |
                             DAY ON TEST   | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2|              |            |
                                           | 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +     +  +                             +                     |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +     +  +                             +                     |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +     +  +                             +                     |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +     +  +                             +                     |   5        |
      Parasite Metazoan                    |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Basophilic Focus                     |             2                       2                                    |      2  2.0|
      Basophilic Focus, Multiple           |          2           2  2  2           2  2  2        2  2               |      9  2.0|
      Eosinophilic Focus                   |                                                          2               |      1  2.0|
      Eosinophilic Focus, Multiple         |             2                                                            |      1  2.0|
      Hepatodiaphragmatic Nodule           |                         3     2                 3                        |      3  2.7|
      Inflammation, Granulomatous, Multiple| 1        1  1           2  3           1  2  2  1        1               |     10  1.5|
      Mixed Cell Focus                     |                                              2                           |      1  2.0|
      Bile Duct, Hyperplasia               |          1                                                               |      1  1.0|
      Hepatocyte, Hypertrophy              |             1                                            1               |      2  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 1                 1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                   +                        |   2        |
      Fat, Necrosis, Focal                 |             3                                   3                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +        +  +  +     +     +                 +                  |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +        +  +  +     +     +                 +                  |   9        |
      Edema                                | 3                                                                        |      1  3.0|
      Epithelium, Hyperplasia              | 3     2  3        2                                                      |      4  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +        +  +  +     +     +                 +                  |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +        +                                                         |   2        |
      Inflammation, Chronic                |                3                                                         |      1  3.0|
      Mineralization, Multifocal           |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +        +  +  +  +  +                       +               |   8        |
      Pars Distalis, Cyst                  |                         3                                                |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                      3           3                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                          +               |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7|              |            |
                             DAY ON TEST   | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2|              |            |
                                           | 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                         +        +           +  +        +               |   5        |
      Duct, Cyst                           |                         3        X           2  2        3               |      5  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Atrophy                              |                                  2                                       |      1  2.0|
      Dilatation                           |    2                                                  2                  |      2  2.0|
      Cervix, Myometrium, Hypertrophy      |          4              3                                                |      2  3.5|
      Endometrium, Hyperplasia, Cystic     |                            2                 1                           |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +  +  +  +  +  +        +  +  +  +  +  +  +  +               |  16        |
      Iliac, Hyperplasia, Lymphoid         |    3                                                                     |      1  3.0|
      Mediastinal, Angiectasis             |             3  3  2     3  3           2     2        2  3               |      9  2.6|
      Mediastinal, Hyperplasia, Lymphoid   |          2                                                               |      1  2.0|
      Mediastinal, Pigmentation            |                                                 2  3                     |      2  2.5|
      Pancreatic, Pigmentation             |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +                                      +               |   2        |
      Cyst                                 |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Atrophy                              |                   3                             3                        |      2  3.0|
      Congestion                           | 2           2              2  2  2        2              2               |      7  2.0|
      Depletion Lymphoid                   |                      3              3  2        1  2                     |      5  2.2|
      Hematopoietic Cell Proliferation     |    2     3  2  3  2     2  2  3           2  3     3     2               |     12  2.4|
      Hyperplasia, Histiocytic, Lymphoid   |                                                          3               |      1  3.0|
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
      Pigmentation                         | 2     3        2  3     2     2  2           2  2  2  3  2               |     12  2.3|
      Capsule, Hypertrophy                 | 2  2           1        1     1  1              2  2  1                  |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +              +        +           +        +               |   5        |
      Hyperplasia, Lobular                 |                                     3                                    |      1  3.0|
      Duct, Cyst                           |                            2        2           2                        |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7|              |            |
                             DAY ON TEST   | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2|              |            |
                                           | 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      A     |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                         +  +                    +                        |   3        |
      Calvarium, Hyperostosis              |                         2  2                    2                        |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                                                                  |   2        |
      Hydrocephalus                        | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                         +                                                |   1        |
      Alveolar Epithelium, Hyperplasia     |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hydronephrosis                       |                4                                      4                  |      2  4.0|
      Inflammation, Suppurative            |                                                 4                        |      1  4.0|
      Nephropathy, Chronic                 |          1  3     1  1  2  2           1  1  1     1  3  3               |     12  1.7|
      Bilateral, Hydronephrosis            |                               4                                          |      1  4.0|
      Papilla, Necrosis                    |       4                                         4                        |      2  4.0|
      Pelvis, Hemorrhage                   |                4                                                         |      1  4.0|
      Pelvis, Inflammation, Suppurative    |                3                                                         |      1  3.0|
      Pelvis, Mineralization               |          1           1           1        1                              |      4  1.0|
      Renal Tubule, Mineralization         | 2  1  3     1     1              1  1     1  1                           |      9  1.3|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1  1  2  1  2  1  1  1  1  1  1               |     20  1.1|
      Renal Tubule, Regeneration           |                                  3              4                        |      2  3.5|
      Transitional Epithelium, Hyperplasia | 1  1  2                       1                 3                        |      5  1.6|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +               |  17        |
      Dilatation                           |    2           2           2  3                       3                  |      5  2.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hemorrhage                           |    4                          3                                          |      2  3.5|
      Inflammation, Suppurative            |                      3                                                   |      1  3.0|
      Metaplasia, Squamous                 |    3     2           4        3     4                 3                  |      6  3.2|
      Necrosis                             |    3                          3                 4                        |      3  3.3|
      Transitional Epithelium, Hyperplasia | 3     3     3                    3                                       |      4  3.0|
      Wall, Infiltration Cellular, Lipocyte|       3  2                                4                              |      3  3.0|
      Wall, Proliferation Connective Tissue|          4  2  4  4  3  2     4     4     2           3  3               |     11  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 8| 8| 7| 7| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocyte, Necrosis, Multifocal     | 1                 1        1                                             |      3  1.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Multifocal                       |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3  3  4  3  3  2  2  2  2  4                                             |     10  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2  2  2  3  3  2  3  3  3  2                                             |     10  2.5|
      Pigmentation                         | 3  3  3  2  3  3  3  3  3  3                                             |     10  2.9|
      Capsule, Hypertrophy                 | 1  2  2  1  2  1  2  2  1  1                                             |     10  1.5|
      Capsule, Inflammation, Chronic       |    2  1     3  1  2     2                                                |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 8| 8| 7| 7| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Corticomedullary Junction,           |                                                                          |            |
          Mineralization                   | 1  1  2  1     1  2  2  2  1                                             |      9  1.4|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  1  2                                             |     10  1.9|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Hyperplasia | 1  1  1     1  1     1  1  1                                             |      8  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.600%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |          X                                                               |      1     |
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 1  1  1  1  1  1  1  1  1                                                |      9  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +                                                         |   1        |
      Cyst                                 |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2  3  2  2  3  3  2  2  2  2                                             |     10  2.3|
      Cervix, Cyst                         |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2  2  2  2  3  2  2  2  2  3                                             |     10  2.2|
      Pigmentation                         | 2  3  3  3  2  3  3  3  3  2                                             |     10  2.7|
      Capsule, Hypertrophy                 | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
      Capsule, Inflammation, Chronic       |                   2     2                                                |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.600%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                                                                  |   2        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 2     2                                                                  |      2  2.0|
      Inflammation, Chronic, Multifocal    | 2     2                                                                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Renal Tubule, Mineralization         |                1  1  1     1                                             |      4  1.0|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Subacute               |             1  2     2  2  2                                             |      5  1.8|
      Transitional Epithelium, Hyperplasia | 3  3  3  3  3  2  3  3  2  2                                             |     10  2.7|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                         2                                                |      1  2.0|
      Wall, Proliferation Connective Tissue|       1                 2                                                |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 5| 5| 5| 5| 4| 4| 4| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.600%                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |    1        1                                                            |      2  1.0|
      Inflammation, Granulomatous, Multiple| 1  1     1           1  1                                                |      5  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 1  1  1  1  1        1     1                                             |      7  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
      Fat, Necrosis, Focal                 | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +                                                                     |   1        |
      Epithelium, Hyperplasia              |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           |          3        2        3                                             |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 3  2  2  2  2  2  2  2  1  2                                             |     10  2.0|
      Hematopoietic Cell Proliferation     |             1                                                            |      1  1.0|
      Hypertrophy                          |       1                                                                  |      1  1.0|
      Pigmentation                         | 2  3  2  3  2  2  2  3  3  2                                             |     10  2.4|
      Capsule, Hypertrophy                 | 1  2     1  2  2     1  1  2                                             |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 5| 5| 5| 5| 4| 4| 4| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.600%                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 3                 1     1                                                |      3  1.7|
      Pelvis, Inflammation, Suppurative    | 2                                                                        |      1  2.0|
      Pelvis, Mineralization               | 1                                                                        |      1  1.0|
      Renal Tubule, Mineralization         | 2        1  2  1  1  1  1  1                                             |      8  1.3|
      Renal Tubule, Pigmentation           | 1  2  2  2  1  1  1  1  1  1                                             |     10  1.3|
      Renal Tubule, Regeneration           | 3                                                                        |      1  3.0|
      Transitional Epithelium, Hyperplasia | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +                                             |   9        |
      Transitional Epithelium, Hyperplasia | 3  3  2     1  3  2  3  1  2                                             |      9  2.2|
      Wall, Proliferation Connective Tissue| 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 5| 5| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  M  +  +  +  +  +  +  +                                             |   9        |
      Basophilic Focus                     |                            1                                             |      1  1.0|
      Basophilic Focus, Multiple           |             1           1                                                |      2  1.0|
      Inflammation, Granulomatous, Multiple| 2           1     1     2                                                |      4  1.5|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 1              1                                                         |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +        +     +     +                                             |   5        |
      Fat, Inflammation, Chronic           | 3              2     3     2                                             |      4  2.5|
      Fat, Necrosis, Focal                 |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +                                                                     |   1        |
      Duct, Cyst                           |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                +                                                         |   1        |
      Cyst                                 |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           | 2                                                                        |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +                                                            |   2        |
      Mediastinal, Angiectasis             |       3                                                                  |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |             3                                                            |      1  3.0|
      Mediastinal, Pigmentation            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 5| 5| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |    2  2  2                                                               |      3  2.0|
      Hematopoietic Cell Proliferation     | 2  2  2     2  2  2  2  2                                                |      8  2.0|
      Pigmentation                         | 2  2  2  2        3  3     3                                             |      7  2.4|
      Capsule, Hypertrophy                 | 1  1  2  2  2  2     1  2  1                                             |      9  1.6|
      Capsule, Inflammation, Chronic       |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 |       1  1  1     2     1                                                |      5  1.2|
      Pelvis, Mineralization               |       1              1                                                   |      2  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration, Hyaline           |       3                                                                  |      1  3.0|
      Renal Tubule, Mineralization         | 1  1  1  1  1  1  1  1  1                                                |      9  1.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Suppurative            |                         3                                                |      1  3.0|
      Metaplasia, Squamous                 | 2           2                                                            |      2  2.0|
      Necrosis                             |             3                                                            |      1  3.0|
      Transitional Epithelium, Hyperplasia |          3     3     3                                                   |      3  3.0|
      Wall, Proliferation Connective Tissue|    2     2  4  2  3  2                                                   |      6  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2|              |            |
                                           | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Basophilic Focus                     |                                                    2                     |      1  2.0|
      Basophilic Focus, Multiple           |          2  2        2  2        2  2  2  2                              |      8  2.0|
      Clear Cell Focus                     |                      2                                                   |      1  2.0|
      Clear Cell Focus, Multiple           |             2           1           2                    2               |      4  1.8|
      Degeneration, Cystic                 |                                                          3               |      1  3.0|
      Eosinophilic Focus                   |                                     2     2        2  2  2               |      5  2.0|
      Eosinophilic Focus, Multiple         |                      2                       2                           |      2  2.0|
      Hepatodiaphragmatic Nodule           |                                     2        4                           |      2  3.0|
      Hyperplasia, Nodular                 | 2     2                    2  3                 3                        |      5  2.4|
      Inflammation, Granulomatous, Multiple|             1  2                    1              1                     |      4  1.3|
      Mixed Cell Focus                     |                                  3                                       |      1  3.0|
      Mixed Cell Focus, Multiple           |                                           2                              |      1  2.0|
      Vacuolization Cytoplasmic            |                                                       2                  |      1  2.0|
      Bile Duct, Hyperplasia               | 3  2  2  2  2  2  3  2  2  2  2  2  2  2  2  3  2  2  2  2               |     20  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +        +                           |   2        |
      Fat, Necrosis, Focal                 |                                     2        3                           |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                                                            |   1        |
      Polyarteritis                        |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                               +                 +     +                  |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                               +                 +     +                  |   3        |
      Inflammation, Suppurative            |                                                       4                  |      1  4.0|
      Ulcer                                |                                                 2     4                  |      2  3.0|
      Ulcer, Multiple                      |                               2                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                               +                 +     +                  |   3        |
      Erosion, Multiple                    |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +                                +                           |   4        |
      Inflammation, Chronic                |       2  3  3                                2                           |      4  2.5|
      Atrium, Congestion                   |                                              4                           |      1  4.0|
      Atrium, Dilatation                   |          2                                                               |      1  2.0|
      Atrium, Thrombosis                   |       4     3                                                            |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +                                   +                        |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +                                   +                        |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2|              |            |
                                           | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +                                   +                        |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +                    +  +     +  +     +     +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Depletion Cellular                   |       4  2  4     3  4  4  4  2  4  4  4  3  3  3  3  4  4               |     17  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +                 +                       +     +  +               |   6        |
      Atrophy                              |                                                 3     3                  |      2  3.0|
      Inflammation, Suppurative            |       3                                               4                  |      2  3.5|
      Necrosis                             |                                                       4                  |      1  4.0|
      Duct, Cyst                           | 2                                               3                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                    +                                       |   2        |
      Atrophy                              |             3                    4                                       |      2  3.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Interstitial Cell, Hyperplasia       |                               2                       2                  |      2  2.0|
      Seminiferous Tubule, Atrophy         | 2  1  4  4  4  1  3  4  4  4  3  4  4  4  4  4  3  4  4  4               |     20  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +     +     +     +     +  +  +  +  +     +                  |  13        |
      Deep Cervical, Angiectasis           |                                                       3                  |      1  3.0|
      Mediastinal, Angiectasis             |                                     2                 3                  |      2  2.5|
      Mediastinal, Hemorrhage              |             4           2                                                |      2  3.0|
      Pancreatic, Angiectasis              |                                     2                                    |      1  2.0|
      Pancreatic, Hemorrhage               | 2                                                                        |      1  2.0|
      Renal, Angiectasis                   |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +              +                          +  +                        |   5        |
      Hemorrhage                           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +        +     +                       +     +                        |   5        |
      Hemorrhage                           |             2                                                            |      1  2.0|
      Hyperplasia, Lymphoid                |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           |             2  1                    3              3  2                  |      5  2.2|
      Depletion Lymphoid                   |                                                       1                  |      1  1.0|
      Fibrosis, Focal                      |                                              3                           |      1  3.0|
      Fibrosis                             |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2|              |            |
                                           | 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |             2  3     2  2           2     2        2  2  2               |      9  2.1|
      Inflammation, Granulomatous          |                                  2                                       |      1  2.0|
      Pigmentation                         |                2                    2     2        2  2                  |      5  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                              +        +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                  +  +  +        +     +                  |   5        |
      Compression                          |                                  3                    4                  |      2  3.5|
      Hemorrhage, Multiple                 |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +        +  +                 +  +     +                        |   7        |
      Inflammation, Granulomatous          |                                           3                              |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                           3                              |      1  3.0|
      Alveolus, Pigmentation               |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                              +                           |   1        |
      Lumen, Hyperkeratosis                |                                              4                           |      1  4.0|
      Lumen, Inflammation, Suppurative     |                                              4                           |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Nephropathy, Chronic                 | 2  2  3  4  4  2  3  3  2  3  2  4  4  3  3  3  3  3  4  3               |     20  3.0|
      Pelvis, Mineralization               | 1     1     1  1  1  1  1  1  1  1  1     1  1     1  1  1               |     16  1.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  2  2  1  1  1  1     1  1  1  1               |     19  1.1|
      Transitional Epithelium, Hyperplasia |          2  2                    1  2                    1               |      5  1.6|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 8| 8| 8| 8| 7| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     3 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 1                                                                        |      1  1.0|
      Hepatodiaphragmatic Nodule           |                      2     2                                             |      2  2.0|
      Necrosis, Focal                      |       1                                                                  |      1  1.0|
      Hepatocyte, Necrosis, Multiple       |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pigmentation                         | 1  2  2  2  2  1  1  1  1  1                                             |     10  1.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 8| 8| 8| 8| 7| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     3 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 |          1        1                                                      |      2  1.0|
      Nephropathy                          |                         1  1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 1| 1| 0| 0| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     6 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Degeneration, Focal                  |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 |       1  1  1     1                                                      |      4  1.0|
      Renal Tubule, Pigmentation           |          2  1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 1| 1| 0| 0| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     6 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 4| 4| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      A     |
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     9 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |    1                                                                     |      1  1.0|
      Hepatodiaphragmatic Nodule           |    2                                                                     |      1  2.0|
      Inflammation, Granulomatous, Multiple|       1     1        1                                                   |      3  1.0|
      Bile Duct, Hyperplasia               |    1     1     1     1  1  1                                             |      6  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   1        |
      Fat, Necrosis, Focal                 |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pigmentation                         | 3  2  2  2  3  3  2  2  3  3                                             |     10  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 4| 4| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      A     |
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     9 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Cataract                             |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  1  1  1  2  2  1  2  2  1                                             |     10  1.5|
      Pelvis, Mineralization               | 1                    1  1  1                                             |      4  1.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  2  1  1                                             |     10  1.1|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 0| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |          1              1  1                                             |      3  1.0|
      Basophilic Focus, Multiple           | 1                                                                        |      1  1.0|
      Clear Cell Focus                     |                         1                                                |      1  1.0|
      Eosinophilic Focus                   |    1                                                                     |      1  1.0|
      Inflammation, Granulomatous, Multiple|    1  1     1  2  2  1     1                                             |      7  1.3|
      Vacuolization Cytoplasmic            | 1           2     1  1                                                   |      4  1.3|
      Bile Duct, Hyperplasia               | 1  1  1  2  1     1  1  1  2                                             |      9  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +           +                                             |   2        |
      Fat, Necrosis, Focal                 |                3           2                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                M                                                         |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +                                                      |   2        |
      Atrium, Congestion                   |                3  3                                                      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      | 2              1                                                         |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|                                            |            |
                                           | 5| 5| 5| 6| 6| 0| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |    3        2        1     2                                             |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +                                                      |   2        |
      Pancreatic, Hyperplasia, Lymphoid    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +                                                         |   1        |
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   1        |
      Hyperplasia, Lymphoid                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2     2  2  2     2  2     2                                             |      7  2.0|
      Hematopoietic Cell Proliferation     | 2        2        2        2                                             |      4  2.0|
      Pigmentation                         | 2  3     2  2  3  2        2                                             |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +                                                      |   2        |
      Epidermis, Fibrosis, Focal           | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  2  1  2  2  1  2  1  1  1                                             |     10  1.5|
      Pelvis, Inflammation, Suppurative    |                2                                                         |      1  2.0|
      Pelvis, Mineralization               |       1     1     1                                                      |      3  1.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7|              |            |
                                           | 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
      Dilatation                           |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
      Hemorrhage                           |                                     3                 4                  |      2  3.5|
      Intussusception                      |                                     X  X        X     X                  |      4     |
      Parasite Metazoan                    |                                                 3                        |      1  3.0|
      Epithelium, Hyperplasia              |                         3     3        3              3                  |      4  3.0|
      Serosa, Inflammation, Chronic        |                                                 3                        |      1  3.0|
      Wall, Proliferation Connective Tissue|                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +               |  18        |
      Epithelium, Hyperplasia              | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Eosinophilic Focus                   |                                        1                                 |      1  1.0|
      Hematopoietic Cell Proliferation     |                            2                                             |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                     3                                    |      1  3.0|
      Inflammation, Granulomatous, Multiple|                   2  2  2           1  2  1           2  2               |      8  1.8|
      Vacuolization Cytoplasmic            |                                              2                           |      1  2.0|
      Hepatocyte, Hypertrophy              |                                                 1  1                     |      2  1.0|
      Hepatocyte, Necrosis, Multifocal     |                                              3                           |      1  3.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 3     1  1  1  2  2  2  2  1  2  2  2  1     2  2  1  2  2               |     18  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +     +              +                    +                        |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +              +                    +                        |   5        |
      Inflammation, Suppurative            |             3                                                            |      1  3.0|
      Ulcer                                |             3                                                            |      1  3.0|
      Epithelium, Hyperplasia              |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +              +                    +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7|              |            |
                                           | 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Depletion Cellular                   | 3                             4              4  4  2                     |      5  3.4|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                              M                           |            |
                                            __________________________________________________________________________|____________|
   Prostate                                |                   +                                                      |   1        |
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Seminiferous Tubule, Atrophy         | 3     2  3  2     2     1  1  3  1  1  1  1  4  3     2                  |     15  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                             +  +                                    |   3        |
      Bronchial, Hyperplasia, Lymphoid     |                                     3                                    |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                  3  3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                                                     |   1        |
      Fibrosis                             |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           | 2  2  2     2     2  2  3        2  3  2  2  2  2  2  2  1               |     16  2.1|
      Depletion Lymphoid                   | 1  3  2     3  2  1           3  3        2  4  3  2     1               |     13  2.3|
      Fibrosis                             |                      2     2     2                                       |      3  2.0|
      Hematopoietic Cell Proliferation     | 3        3     3        2  4  3                          1               |      7  2.7|
      Pigmentation                         | 2              1  2  2  2        3     2     3  3  3  2  2               |     12  2.3|
      Capsule, Hypertrophy                 | 3  2  2  2  3  3  3  3  3  2  2  3  3  3  2  3  3  3  3  2               |     20  2.7|
      Capsule, Inflammation, Chronic       | 3  2  2  1  1  2  3  3  3  2  2  3  2  3  2  2  3  4  2  2               |     20  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                     +                                    |   1        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2|              |            |
                             DAY ON TEST   | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7|              |            |
                                           | 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Lymphocyte                      |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hydronephrosis                       |    4     4     3                 4  3                                    |      5  3.6|
      Infarct                              |                      2        4                 2                        |      3  2.7|
      Nephropathy, Chronic                 | 2           2  2  1  1  2     2  2  2  1  1     2  2  2                  |     14  1.7|
      Papilla, Necrosis                    |                                              4                           |      1  4.0|
      Pelvis, Dilatation                   | 3                                                                        |      1  3.0|
      Pelvis, Mineralization               |    1  1     1  2     2        2     1  1  1     2  1  1  1               |     13  1.3|
      Renal Tubule, Dilatation             |                                                    3                     |      1  3.0|
      Renal Tubule, Mineralization         |                   2                          2                           |      2  2.0|
      Renal Tubule, Necrosis               |                                              4                           |      1  4.0|
      Renal Tubule, Pigmentation           | 3  2  2  1  2  3  3  3  2  2  3  2  2  2  2  3  3  2  2  2               |     20  2.3|
      Renal Tubule, Regeneration           |                                  3  3           3                        |      3  3.0|
      Transitional Epithelium, Hyperplasia |       2     1  3  2  3        2     3        2  3  1  2                  |     11  2.2|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Dilatation                           | 2  2     3                       2  3              3                     |      6  2.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   1        |
      Transitional Epithelium, Hyperplasia |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hemorrhage                           | 4              3                                   3                     |      3  3.3|
      Inflammation, Suppurative            |                         2        3                 4                     |      3  3.0|
      Metaplasia, Squamous                 | 3  4  4  3  2  4  4  4  4  2  3  4  3  2        3  4  3  3               |     18  3.3|
      Transitional Epithelium, Hyperplasia |                                              3                           |      1  3.0|
      Wall, Proliferation Connective Tissue| 3  3     4  3  3  2  3  2     3  4  4           2  2  4  4               |     15  3.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 8| 8| 7| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1.80%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
      3 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocyte, Hypertrophy              | 2  2  2  2  3  2  2  2  3  2                                             |     10  2.2|
      Hepatocyte, Necrosis, Multifocal     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |          2  1  1                                                         |      3  1.3|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  2  2  2  2  2  2  2  1  2                                             |     10  1.9|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Depletion Cellular                   | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2  3  2  2     2  2  2  2  3                                             |      9  2.2|
      Degeneration                         | 2  4  2  3  1  3  3  3  2  3                                             |     10  2.6|
      Edema                                | 2     2  2  2  2        2  2                                             |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|
      Depletion Lymphoid                   | 3  2  3  3  3  3  3  3  3  3                                             |     10  2.9|
      Pigmentation                         | 3  3  3  3  3  3  3  3  3  3                                             |     10  3.0|
      Capsule, Hypertrophy                 | 3  3  3  2  2  3  3  2  2  2                                             |     10  2.5|
      Capsule, Inflammation, Chronic       | 3  3  2  3  3  3  3  2  3  3                                             |     10  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 7| 7| 8| 8| 7| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    1.80%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
      3 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 |    2  2  1     2  2  2     1                                             |      7  1.7|
      Renal Tubule, Pigmentation           | 3  3  3  4  3  4  4  3  3  3                                             |     10  3.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Subacute               | 2  2  2  1  2  2  2  2  2  3                                             |     10  2.0|
      Metaplasia, Squamous                 | 3  3  4  3  4  3  4  4  2  4                                             |     10  3.4|
      Transitional Epithelium, Hyperplasia | 3  4  4  3     4  4  4  4  4                                             |      9  3.8|
      Wall, Proliferation Connective Tissue| 3  2  2  2  2  2  2  2  2  2                                             |     10  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 0| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
      6 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +           +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +                                                      |   3        |
      Epithelium, Hyperplasia              |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +           +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous, Multiple|          2                                                               |      1  2.0|
      Hepatocyte, Hypertrophy              | 2  3  3  2  2  3  3  3  2  3                                             |     10  2.6|
      Hepatocyte, Necrosis, Multifocal     | 2  2  2  2  2  1  2  2  1  2                                             |     10  1.8|
      Hepatocyte, Vacuolization Cytoplasmic| 1     1  1     2  2     1                                                |      6  1.3|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Depletion Cellular                   | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3  3  2  3  3  2  3  2  3  3                                             |     10  2.7|
      Degeneration                         | 2  2  2  3  2  2  3  2  3  3                                             |     10  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 4  4  4  3  4  4  4  4  4  4                                             |     10  3.9|
      Depletion Lymphoid                   | 3  4  4  3  3  3  3  4  3  2                                             |     10  3.2|
      Fibrosis                             |       2  2                                                               |      2  2.0|
      Pigmentation                         |       2  2  2  1  2  2  2  2                                             |      8  1.9|
      Capsule, Hypertrophy                 | 3  4  4  3  3  3  3  3  3  3                                             |     10  3.2|
      Capsule, Inflammation, Chronic       | 2  3  3  3  3  3  3  2  2  2                                             |     10  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 1| 1| 1| 0| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      A     |
    1.80%                                  | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
      6 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  1  2  2  1  2  2  2  2  2                                             |     10  1.8|
      Pigmentation                         |       4                                                                  |      1  4.0|
      Pelvis, Mineralization               |                      3                                                   |      1  3.0|
      Renal Tubule, Mineralization         |          1                                                               |      1  1.0|
      Renal Tubule, Pigmentation           | 3  3     3  3  3  3  3  3  3                                             |      9  3.0|
      Renal Tubule, Regeneration           | 2  2  2  2  1  2  2  2  2  2                                             |     10  1.9|
      Transitional Epithelium, Hyperplasia |          2     1  3  2  2                                                |      5  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Transitional Epithelium, Hyperplasia |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst, Multiple                       |    X                                                                     |      1     |
      Inflammation, Subacute               |    2  2  2     2  2  3  2                                                |      7  2.1|
      Metaplasia, Squamous                 | 3  4  3  4  4  4  4  2  4  4                                             |     10  3.6|
      Wall, Proliferation Connective Tissue| 3  3  2  2     3  4  4  3  3                                             |      9  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                                           | 8| 3| 4| 5| 5| 7| 2| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.80%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
      9 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +  +        +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +  +        +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +  +        +     +                                             |   5        |
      Parasite Metazoan                    |          3                                                               |      1  3.0|
      Epithelium, Hyperplasia              |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +  +        +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                         X                                                |      1     |
      Eosinophilic Focus, Multiple         |    1                                                                     |      1  1.0|
      Inflammation, Granulomatous, Multiple|    2  2  2  2  2     2  2  2                                             |      8  2.0|
      Hepatocyte, Hypertrophy              | 1                                                                        |      1  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  1     1  2  1  1  2  1  1                                             |      9  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                    +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                    +                                                   |   2        |
      Epithelium, Hyperplasia              | 2                    2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                    +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Depletion Cellular                   | 4  2                       1                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Seminiferous Tubule, Atrophy         | 1  2  1  1                 2                                             |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |          3  2  2     3  3  3                                             |      6  2.7|
      Depletion Lymphoid                   |                2  3                                                      |      2  2.5|
      Hematopoietic Cell Proliferation     | 3     3  2  3        2     2                                             |      6  2.5|
      Pigmentation                         |    2     1     2                                                         |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                                           | 8| 3| 4| 5| 5| 7| 2| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.80%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
      9 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           | X                                                                        |      1     |
      Capsule, Hypertrophy                 | 3  2  2  2  2  3  3  2  2  3                                             |     10  2.4|
      Capsule, Inflammation, Chronic       | 2  3  2  2  2  1  1  1  1  2                                             |     10  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Fibrosis                             |       3                                                                  |      1  3.0|
      Hydronephrosis                       |    2  4           1  4                                                   |      4  2.8|
      Nephropathy, Chronic                 | 2  2  2  2  2  2     2  1  2                                             |      9  1.9|
      Pelvis, Dilatation                   |                         2                                                |      1  2.0|
      Pelvis, Mineralization               |                      1  2                                                |      2  1.5|
      Renal Tubule, Mineralization         |                   2                                                      |      1  2.0|
      Renal Tubule, Pigmentation           | 2  2  3  1  2  2  2  2  1  2                                             |     10  1.9|
      Renal Tubule, Regeneration           |    2  3        2     3                                                   |      4  2.5|
      Transitional Epithelium, Hyperplasia |          2  3  2           2                                             |      4  2.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           | 1  2  3           3                                                      |      4  2.3|
      Transitional Epithelium, Hyperplasia |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |    4              3                                                      |      2  3.5|
      Inflammation, Subacute               |                      3  2  2                                             |      3  2.3|
      Inflammation, Suppurative            |       3     3     3                                                      |      3  3.0|
      Metaplasia, Squamous                 |    4     2     3     2  4  2                                             |      6  2.8|
      Wall, Proliferation Connective Tissue| 3  2  4  2        2     4  3                                             |      7  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9|                                            |            |
                                           | 0| 6| 8| 3| 9| 6| 9| 2| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +                                             |   9        |
      Dilatation                           |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +                                             |   9        |
      Hemorrhage                           |          4           2                                                   |      2  3.0|
      Intussusception                      |          X           X                                                   |      2     |
      Necrosis                             |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia              |    3     4        4  3  4                                                |      5  3.6|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous, Multiple|             1  1  3  2     1                                             |      5  1.6|
      Hepatocyte, Hypertrophy              |    2     1     2                                                         |      3  1.7|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 2  2  2  2  1  2  2        2                                             |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Depletion Cellular                   |    4  4                                                                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +        +     +                                                      |   4        |
      Inflammation, Suppurative            |    4        4                                                            |      2  4.0|
      Proliferation Connective Tissue      |                   4                                                      |      1  4.0|
      Epithelium, Hyperplasia              |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   1        |
      Epithelium, Hyperplasia              |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Seminiferous Tubule, Atrophy         | 1  2  2        2                                                         |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +           +  +                                                   |   3        |
      Iliac, Hyperplasia, Lymphoid         |       3                                                                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9|                                            |            |
                                           | 0| 6| 8| 3| 9| 6| 9| 2| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Hyperplasia, Lymphoid    |                   3  3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |             2  2  2  2  2  2                                             |      6  2.0|
      Depletion Lymphoid                   | 4  3     2  1  3                                                         |      5  2.6|
      Fibrosis                             |    3                                                                     |      1  3.0|
      Hematopoietic Cell Proliferation     |    3  4           2  2                                                   |      4  2.8|
      Inflammation, Chronic                |          2                                                               |      1  2.0|
      Pigmentation                         | 3        3     2  2        2                                             |      5  2.4|
      Capsule, Hypertrophy                 | 4  3  2  3  2  3  3  2  2  2                                             |     10  2.6|
      Capsule, Inflammation, Chronic       | 3  2  2     2  1  3  2  2  2                                             |      9  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +  +                                                         |   2        |
      Atrophy                              |             3  4                                                         |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydronephrosis                       | 4           4     3                                                      |      3  3.7|
      Nephropathy, Chronic                 |    2  2  2     1  2  1  1                                                |      7  1.6|
      Bilateral, Hydronephrosis            |                            4                                             |      1  4.0|
      Pelvis, Mineralization               |    1     2  1  1  1     1  2                                             |      7  1.3|
      Pelvis, Necrosis                     |                            3                                             |      1  3.0|
      Renal Tubule, Pigmentation           | 2  3  2  2  2  3  3  2  2  1                                             |     10  2.2|
      Renal Tubule, Regeneration           | 2                                                                        |      1  2.0|
      Transitional Epithelium, Hemorrhage  | 4                                                                        |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 3| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9|                                            |            |
                                           | 0| 6| 8| 3| 9| 6| 9| 2| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    1.80%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Transitional Epithelium, Hyperplasia |    2     2  3  2  3  3  3                                                |      7  2.6|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           | 3  2        2     3        3                                             |      5  2.6|
      Hemorrhage                           | 4                                                                        |      1  4.0|
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Metaplasia, Squamous                 | 2  3  2  4  4  4  4  3  3  3                                             |     10  3.2|
      Transitional Epithelium, Hyperplasia | 3                                                                        |      1  3.0|
      Wall, Proliferation Connective Tissue| 3  3           4  3  2     4                                             |      6  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8|              |            |
                                           | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
      Edema                                |                            2                       3                     |      2  2.5|
      Parasite Metazoan                    |                   2                                                      |      1  2.0|
      Submucosa, Proliferation Connective  |                                                                          |            |
          Tissue                           |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
      Edema                                |                                                    3                     |      1  3.0|
      Fibrosis                             |    3                                                                     |      1  3.0|
      Hemorrhage                           |                                                 3        4               |      2  3.5|
      Serosa, Inflammation, Chronic        |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +     +  +  +     +  +     +  +  +  +  +  +  +     +               |  15        |
      Hemorrhage                           |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +        +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Basophilic Focus                     |                         2                    1                           |      2  1.5|
      Basophilic Focus, Multiple           |             1                                         1  2               |      3  1.3|
      Clear Cell Focus                     |                                              2                           |      1  2.0|
      Eosinophilic Focus                   |                         2                          2                     |      2  2.0|
      Eosinophilic Focus, Multiple         |                            4                                             |      1  4.0|
      Hematopoietic Cell Proliferation     |             2        1                                                   |      2  1.5|
      Hepatodiaphragmatic Nodule           |       3                                                                  |      1  3.0|
      Inflammation, Granulomatous, Multiple| 1  2           1        2                    1        1                  |      6  1.3|
      Mixed Cell Focus                     |             2                                                            |      1  2.0|
      Thrombosis                           |                                                    3                     |      1  3.0|
      Vacuolization Cytoplasmic            |                                                       1  2               |      2  1.5|
      Bile Duct, Hyperplasia               |             2  1     1  1  2                 2     2                     |      7  1.6|
      Centrilobular, Degeneration          |                      3                                                   |      1  3.0|
      Hepatocyte, Necrosis, Multiple       |                3                                                         |      1  3.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     |          1                                                               |      1  1.0|
      Serosa, Fibrosis                     |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +  +                                                |   2        |
      Thrombosis                           |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                      +     +                          +  +               |   4        |
      Edema                                |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8|              |            |
                                           | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Atrophy                 |                                                          2               |      1  2.0|
      Acinar Cell, Hyperplasia             |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +     +                    +     +     +     +  +               |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +     +                    +     +     +     +  +               |   9        |
      Abscess                              |          4                                      1                        |      2  2.5|
      Edema                                |                3                                                         |      1  3.0|
      Mineralization                       |                                                          2               |      1  2.0|
      Epithelium, Hyperplasia              |       3  3     4                                         3               |      4  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +     +                    +     +     +     +  +               |   9        |
      Mineralization                       |          3                                               3               |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                          +               |   1        |
      Aorta, Mineralization                |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |          +                                               +               |   2        |
      Inflammation, Chronic                |          2                                               2               |      2  2.0|
      Mineralization                       |                                                          3               |      1  3.0|
      Atrium, Thrombosis                   |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                            +                             +               |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                            +                             +               |   2        |
      Vacuolization Cytoplasmic, Focal     |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                            +                             +               |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                       +  +               |   2        |
      Hyperplasia                          |                                                       3  3               |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Depletion Cellular                   |       3  4  4     2  4  4  4                 4  2  4  3  4               |     12  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +              +  +                 +     +                     |   6        |
      Atrophy                              |       3                 3                          3                     |      3  3.0|
      Hyperplasia                          |                                                    3                     |      1  3.0|
      Duct, Cyst                           |          3              2  2                       3                     |      4  2.5|
      Duct, Cyst, Multiple                 |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                   +                                                      |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8|              |            |
                                           | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Interstitial Cell, Hyperplasia       |    2     2     2     2           2  2  2  1        1                     |      9  1.8|
      Seminiferous Tubule, Atrophy         |       3  4  4     3  4  4  4              3  4  3  4  4  4               |     13  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +  +  +     +     +  +  +  +  +  +  +  +                  |  14        |
      Iliac, Hyperplasia, Lymphoid         |                                           3                              |      1  3.0|
      Mediastinal, Angiectasis             |                3                                2  3                     |      3  2.7|
      Mediastinal, Congestion              |                                        3                                 |      1  3.0|
      Mediastinal, Pigmentation            |       2              2                 3                                 |      3  2.3|
      Pancreatic, Angiectasis              |       2                                                                  |      1  2.0|
      Pancreatic, Edema                    |                                              3                           |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                       2                  |      1  2.0|
      Renal, Angiectasis                   |                                                       3                  |      1  3.0|
      Renal, Inflammation, Granulomatous   |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +  +           +           +  +  +  +                  |   7        |
      Hyperplasia, Lymphoid                |                                              3  2  2                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +           +        +        +  +  +                     |   8        |
      Angiectasis                          |                3                                2                        |      2  2.5|
      Congestion                           |                                     2                                    |      1  2.0|
      Cyst                                 |             3                                      3                     |      2  3.0|
      Edema                                |       3     3                                      3                     |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Congestion                           | 2  2        2           2     2  2  2  2  2  3        2                  |     11  2.1|
      Fibrosis                             |          3                                                               |      1  3.0|
      Hematopoietic Cell Proliferation     | 2     2  3  2        4     2  3     2  2     2  2  2  2  3               |     14  2.4|
      Pigmentation                         | 2  2  3  2  2  2              2  2     2              2  3               |     11  2.2|
      Capsule, Hypertrophy                 |          2  1  2                 2     2  1  2     3  1                  |      9  1.8|
      Capsule, Inflammation, Chronic       |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                                                            |   1        |
      Duct, Cyst                           |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                                               |   1        |
      Calvarium, Hyperostosis              |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6|              |            |
                             DAY ON TEST   | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8|              |            |
                                           | 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Nephropathy, Chronic                 | 2  3  3  4  3  2  3  2  4  4  3  2  3  2  2  4  2  2  4  4               |     20  2.9|
      Cortex, Cyst                         |          4                                                               |      1  4.0|
      Pelvis, Mineralization               | 3  3  3  2  3  3  3  3  2  3  2  3  3  3  3  3  3  2  2  2               |     20  2.7|
      Renal Tubule, Hyperplasia            |                                                       2                  |      1  2.0|
      Renal Tubule, Pigmentation           | 1  1  2  1  2  1  1  3  2  1  2  1  1  1  1  1  1  2  1  1               |     20  1.4|
      Transitional Epithelium, Hyperplasia | 2  2  2  2  2  1  3  2  2  3  2  2  2  1  2  2  2  2  2  2               |     20  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Dilatation                           |          2                                         2  2                  |      3  2.0|
      Transitional Epithelium, Hyperplasia |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                 +                                    |   2        |
      Bulbourethral Gland, Cyst, Multiple  |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  20        |
      Hemorrhage                           |                                                          3               |      1  3.0|
      Metaplasia, Squamous                 | 2                                                                        |      1  2.0|
      Necrosis                             |                                                 4                        |      1  4.0|
      Transitional Epithelium, Hyperplasia |                3  2        2  2        3  3                              |      6  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 8| 8| 8| 8| 7| 7| 7| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Granulomatous, Multiple| 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |    3  3  2  3  2  3  3  3  3                                             |      9  2.8|
      Pigmentation                         | 3  3  3  3  3  3  3  2  3  3                                             |     10  2.9|
      Capsule, Hypertrophy                 | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Capsule, Inflammation, Chronic       | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 7| 8| 8| 8| 8| 7| 7| 7| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  2  1  2  2  2  2  2  2  2                                             |     10  1.9|
      Pelvis, Mineralization               | 2  2  2  2  2  1  2  2     1                                             |      9  1.8|
      Renal Tubule, Degeneration           | 3  3  3  3  3  3  3  2  3  3                                             |     10  2.9|
      Renal Tubule, Necrosis               | 2  3  3  3  2  2  3  2  3  3                                             |     10  2.6|
      Renal Tubule, Pigmentation           | 1     2  1  1  2  2  2  2  2                                             |      9  1.7|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 1| 1| 0| 0| 0| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Artery, Inflammation, Chronic, Focal |                      3                                                   |      1  3.0|
      Hepatocyte, Necrosis, Multifocal     | 1                                                                        |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1  1                    1                                                |      3  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     |    1     1  1                                                            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2  3  3  3  2  2  3  2  3  2                                             |     10  2.5|
      Pigmentation                         | 3  2  2  3  2  3  3  3  3  2                                             |     10  2.6|
      Capsule, Hypertrophy                 |    2     2     2  2  2  2  2                                             |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 0| 0| 0| 1| 1| 0| 0| 0| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    6 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +           +                                             |   2        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                2           2                                             |      2  2.0|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
      Inflammation                         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 3  2  3  2  2  2  2  3  2  2                                             |     10  2.3|
      Pigmentation                         |                            2                                             |      1  2.0|
      Renal Tubule, Mineralization         | 3  3  3  3  2  3  2  3  2  2                                             |     10  2.6|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2                                                |      9  2.0|
      Renal Tubule, Regeneration           | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Transitional Epithelium, Hyperplasia | 2  2  3  3  2  3  3  3  3  2                                             |     10  2.6|
      Wall, Proliferation Connective Tissue|                      1                                                   |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +     +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |          1                                                               |      1  1.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 2                                                                        |      1  2.0|
      Inflammation, Granulomatous, Multiple|    2  1  1  1  1  2  2  1  2                                             |      9  1.4|
      Vacuolization Cytoplasmic            | 3  2                 2                                                   |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   1        |
      Hyperplasia                          |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Interstitial Cell, Hyperplasia       |                      2  1                                                |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   1        |
      Pancreatic, Hyperplasia              |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           | 2  2  2  2  2  2  3  2  2  3                                             |     10  2.2|
      Hematopoietic Cell Proliferation     |    2        2                                                            |      2  2.0|
      Pigmentation                         | 3  2  3  2  2  2  2  2  2  3                                             |     10  2.3|
      Capsule, Hypertrophy                 | 1  2  1     1  1  2  1     2                                             |      8  1.4|
      Capsule, Inflammation, Chronic       |    2                       1                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                                           | 4| 4| 4| 5| 5| 4| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    9 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +                                                               |   2        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
      Cornea, Edema                        |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  2  2  2  3  2  3  3  2  3                                             |     10  2.4|
      Pelvis, Mineralization               | 3  3  3  3  3  3  3  3  3  3                                             |     10  3.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Transitional Epithelium, Hyperplasia |    2  2  2  2     2  1  2                                                |      7  1.9|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
      Transitional Epithelium, Hyperplasia | 3  2  3  2  2  4  3     1  2                                             |      9  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5|                                            |            |
                                           | 5| 4| 4| 8| 6| 9| 9| 0| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatodiaphragmatic Nodule           |                            2                                             |      1  2.0|
      Inflammation, Granulomatous, Multiple| 1  1  1     2  1  1  2  1  2                                             |      9  1.3|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +                                                               |   3        |
      Inflammation, Suppurative            |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                               |   1        |
      Adventitia, Edema                    |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |    2                                                                     |      1  2.0|
      Interstitial Cell, Hyperplasia       |       2        2  1                                                      |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +     +                                                      |   3        |
      Iliac, Angiectasis                   |          3                                                               |      1  3.0|
      Renal, Angiectasis                   |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +     +                                                      |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5|                                            |            |
                                           | 5| 4| 4| 8| 6| 9| 9| 0| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                   X                                                      |      1     |
      Hyperplasia, Lymphoid                |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |       3     2  2  2  2                                                   |      5  2.2|
      Hematopoietic Cell Proliferation     |    2  2     2  2  2  2  2                                                |      7  2.0|
      Hyperplasia, Lymphoid                | 2        3                                                               |      2  2.5|
      Pigmentation                         |             2  2  2  2     3                                             |      5  2.2|
      Capsule, Hypertrophy                 | 1  1  1     1  1  1  1  1                                                |      8  1.0|
      Capsule, Inflammation, Chronic       |       1        1  1  1  1                                                |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                                                                  |   2        |
      Congestion                           | 2     1                                                                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  2  3  3  4  2  2  3  2  3                                             |     10  2.6|
      Bilateral, Hydronephrosis            | 3        3                                                               |      2  3.0|
      Pelvis, Dilatation                   |             2                                                            |      1  2.0|
      Pelvis, Mineralization               | 3  3  3  3  3  3  3  3  4  3                                             |     10  3.1|
      Renal Tubule, Mineralization         |          2                                                               |      1  2.0|
      Renal Tubule, Pigmentation           |    1  1  1  1  1  1  1  2  1                                             |      9  1.1|
      Renal Tubule, Regeneration           | 2        2                 3                                             |      3  2.3|
      Transitional Epithelium, Hyperplasia |       2  3  3     2  2  2  2                                             |      7  2.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +  +  M  +  +  +  M  +  +                                             |   8        |
      Dilatation                           | 4           2                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05092-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: SPECIAL STUDY                                     O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:37:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5|                                            |            |
                                           | 5| 4| 4| 8| 6| 9| 9| 0| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.600%                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Squamous                 | 4        3                                                               |      2  3.5|
      Transitional Epithelium, Hyperplasia |                3  2  2     2                                             |      4  2.3|
      Wall, Proliferation Connective Tissue|          4  3                                                            |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
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