TDMS Study 05092-03 Pathology Tables
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
Facility: Southern Research Institute
Chemical CAS #: 0091-23-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2| | |
| 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | 1 | 1 1.0|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 14 2.0|
Eosinophilic Focus | 1 1 3 2 | 4 1.8|
Eosinophilic Focus, Multiple | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 2 2 | 2 2.0|
Inflammation, Granulomatous, Multiple| 1 1 1 2 2 1 2 1 2 1 2 2 1 2 | 14 1.5|
Mixed Cell Focus | 2 2 3 3 | 4 2.5|
Vacuolization Cytoplasmic | 3 4 3 | 3 3.3|
Bile Duct, Hyperplasia | 2 1 2 1 1 | 5 1.4|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 1 2 1 2 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
Diverticulum | 2 | 1 2.0|
Edema | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
Bilateral, Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2| | |
| 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 12 |
Pars Distalis, Hemorrhage | 4 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 3 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + M + + | 19 |
Dilatation | 3 2 | 2 2.5|
Fibrosis, Focal | 2 | 1 2.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
Cervix, Cyst | 3 | 1 3.0|
Cervix, Myometrium, Hypertrophy | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 3 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 14 |
Deep Cervical, Angiectasis | 3 | 1 3.0|
Mediastinal, Angiectasis | 2 2 | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Pigmentation | 2 3 2 | 3 2.3|
Pancreatic, Angiectasis | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 7 |
Cyst | 2 | 1 2.0|
Cyst, Multiple | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 2 2 3 2 2 3 2 2 2 2 2 | 11 2.2|
Depletion Lymphoid | 1 3 2 1 | 4 1.8|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 | 15 2.1|
Hyperplasia, Histiocytic, Lymphoid | 3 | 1 3.0|
Pigmentation | 3 3 3 3 2 2 3 3 2 3 2 3 3 3 2 | 15 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 2| 2| 0| 2| 2| 2| 2| 4| 6| 2| 2| 2| 9| 2| 2| 2| 2| | |
| 1| 9| 8| 9| 9| 3| 9| 9| 9| 9| 8| 2| 9| 9| 9| 0| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | A |
0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + | 13 |
Hyperplasia, Lobular | 2 3 2 3 3 3 2 2 | 8 2.5|
Duct, Cyst | 3 2 3 2 3 2 3 3 2 | 9 2.6|
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
Calvarium, Hyperostosis | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
Compression | 2 3 3 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Congestion | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy, Chronic | 2 2 2 2 1 1 1 3 2 1 2 2 1 1 2 1 2 2 | 18 1.7|
Pelvis, Mineralization | 1 1 1 1 1 | 5 1.0|
Renal Tubule, Mineralization | 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 17 1.1|
Renal Tubule, Pigmentation | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 18 1.1|
__________________________________________________________________________|____________|
Ureter | + + + + + M + + + + M + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + M + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 8| 8| 8| 7| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Hepatocyte, Necrosis, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 2 2 2 2 2 2 2 2 1 2 | 10 1.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Corticomedullary Junction, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 8| 8| 8| 7| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization | 1 2 2 2 1 2 1 2 2 | 9 1.7|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 0| 1| 0| 0| 0| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Granulomatous, | | |
Multifocal | 1 | 1 1.0|
Inflammation, Granulomatous, Multiple| 2 1 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 3 2 3 3 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 0| 1| 0| 0| 0| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Corticomedullary Junction, | | |
Mineralization | 2 2 | 2 2.0|
Renal Tubule, Mineralization | 1 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Ureter | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 5| 4| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 1 1 1 | 5 1.0|
Inflammation, Granulomatous, Multiple| 1 1 1 1 1 | 5 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Pigmentation | 3 2 3 2 3 | 5 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 5| 4| 4| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 1 1 1 1 1 | 5 1.0|
Pelvis, Mineralization | 1 | 1 1.0|
Renal Tubule, Mineralization | 1 1 1 1 1 1 1 2 2 | 9 1.2|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5| | |
| 5| 5| 5| 6| 6| 8| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus, Multiple | 2 1 1 1 1 1 1 | 7 1.1|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Granulomatous, Multiple| 1 1 | 2 1.0|
Bile Duct, Hyperplasia | 1 1 | 2 1.0|
Hepatocyte, Hypertrophy | 2 1 1 | 3 1.3|
Hepatocyte, Mitotic Alteration | 3 | 1 3.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis, Focal | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 2 |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 2 2 | 5 2.0|
Hematopoietic Cell Proliferation | 2 2 4 2 | 4 2.5|
Pigmentation | 3 2 2 2 2 3 | 6 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 1| 5| 5| 5| | |
| 5| 5| 5| 6| 6| 8| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 1 1 1 1 1 1 | 6 1.0|
Pelvis, Mineralization | 1 1 | 2 1.0|
Renal Tubule, Mineralization | 1 1 1 2 2 2 2 1 | 8 1.5|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Ureter | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3| | |
DAY ON TEST | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0| | |
| 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
Parasite Metazoan | 2 | 1 2.0|
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Inflammation, Granulomatous, Multiple| 2 2 1 2 1 2 2 2 2 2 2 2 2 2 1 | 15 1.8|
Bile Duct, Hyperplasia | 2 | 1 2.0|
Hepatocyte, Hypertrophy | 1 | 1 1.0|
Hepatocyte, Necrosis, Multifocal | 1 | 1 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 2 2 2 2 1 | 20 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + | 3 |
Ectopic Tissue | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 7 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 7 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Ovary | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3| | |
DAY ON TEST | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0| | |
| 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 2 4 3 3 4 3 3 4 2 4 4 3 2 3 3 2 4 3 3 4 | 20 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 5 |
Iliac, Hyperplasia, Lymphoid | 3 2 4 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 3 1 1 2 2 3 1 2 2 2 2 2 2 4 2 2 2 | 17 2.1|
Depletion Lymphoid | 3 3 3 3 3 1 3 1 | 8 2.5|
Hematopoietic Cell Proliferation | 3 3 2 3 2 3 3 2 3 3 2 2 3 2 2 | 15 2.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation | 2 3 1 2 2 2 2 2 | 8 2.0|
Capsule, Hypertrophy | 3 2 2 2 2 2 2 2 2 2 1 2 2 3 2 3 3 2 2 2 | 20 2.2|
Capsule, Inflammation, Chronic | 3 2 2 2 2 2 2 2 2 2 3 2 2 2 1 2 2 | 17 2.1|
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Hydronephrosis | 2 3 4 4 3 4 4 2 3 4 2 | 11 3.2|
Nephropathy, Chronic | 1 1 | 2 1.0|
Bilateral, Hydronephrosis | 4 1 3 | 3 2.7|
Papilla, Necrosis | 3 | 1 3.0|
Pelvis, Dilatation | 2 3 | 2 2.5|
Pelvis, Mineralization | 1 1 1 1 1 2 1 1 | 8 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 0| 2| 2| 2| 3| 2| 2| 2| 2| 3| | |
DAY ON TEST | 4| 0| 2| 3| 4| 0| 2| 3| 0| 2| 4| 1| 2| 3| 0| 4| 6| 6| 8| 0| | |
| 7| 9| 4| 3| 0| 7| 7| 6| 8| 5| 8| 9| 1| 9| 7| 8| 8| 8| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Necrosis | 2 | 1 2.0|
Renal Tubule, Mineralization | 2 1 1 2 1 2 1 1 1 | 9 1.3|
Renal Tubule, Pigmentation | 2 2 3 2 2 2 2 2 1 2 1 3 3 2 2 2 3 2 2 2 | 20 2.1|
Renal Tubule, Regeneration | 3 3 | 2 3.0|
Transitional Epithelium, Hyperplasia | 2 4 2 3 2 2 3 2 2 | 9 2.4|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + M + + + + + + + + + | 19 |
Dilatation | 2 2 3 4 3 2 2 2 4 4 2 2 2 3 2 | 15 2.6|
Transitional Epithelium, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemorrhage | 3 4 | 2 3.5|
Inflammation, Subacute | 3 | 1 3.0|
Inflammation, Suppurative | 3 3 3 4 3 | 5 3.2|
Metaplasia, Squamous | 3 4 3 3 2 3 3 4 3 2 3 2 2 | 13 2.8|
Necrosis | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
Wall, Infiltration Cellular, Lipocyte| 3 3 | 2 3.0|
Wall, Proliferation Connective Tissue| 3 4 4 4 2 3 3 2 4 3 3 4 4 3 | 14 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
Hepatocyte, Hypertrophy | 2 3 2 2 2 2 2 2 1 2 | 10 2.0|
Hepatocyte, Necrosis, Multifocal | 2 1 2 1 1 1 2 1 1 1 | 10 1.3|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 1 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Multifocal | 1 | 1 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 3 2 2 2 2 2 2 3 | 10 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 4 4 4 4 4 4 4 4 3 4 | 10 3.9|
Depletion Lymphoid | 2 2 3 3 3 3 3 3 3 3 | 10 2.8|
Pigmentation | 2 3 2 3 2 3 3 2 3 3 | 10 2.6|
Capsule, Hypertrophy | 2 2 3 2 2 2 2 2 3 2 | 10 2.2|
Capsule, Inflammation, Chronic | 2 2 3 2 3 3 2 3 3 | 9 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Corticomedullary Junction, | | |
Mineralization | 2 1 2 2 1 1 1 1 2 | 9 1.4|
Renal Tubule, Pigmentation | 3 3 3 4 3 3 3 4 3 3 | 10 3.2|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Inflammation, Subacute | 2 3 2 3 3 2 2 2 | 8 2.4|
Metaplasia, Squamous | 3 2 3 3 2 4 3 4 2 3 | 10 2.9|
Transitional Epithelium, Hyperplasia | 3 3 4 4 3 4 4 4 4 4 | 10 3.7|
Wall, Proliferation Connective Tissue| 3 2 2 2 2 2 | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Granulomatous, Multiple| 2 2 2 2 2 | 5 2.0|
Hepatocyte, Hypertrophy | 3 3 2 3 3 2 2 2 2 2 | 10 2.4|
Hepatocyte, Necrosis, Multifocal | 2 2 1 2 2 2 2 2 2 2 | 10 1.9|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 1 2.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 4 3 3 2 4 2 4 | 10 2.8|
Depletion Lymphoid | 3 2 3 2 3 3 3 2 3 3 | 10 2.7|
Pigmentation | 2 2 2 2 2 2 2 2 2 | 9 2.0|
Capsule, Hypertrophy | 2 2 3 3 3 3 3 3 3 3 | 10 2.8|
Capsule, Inflammation, Chronic | 2 2 3 3 3 3 2 3 2 3 | 10 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Corticomedullary Junction, | | |
Mineralization | 2 1 | 2 1.5|
Renal Tubule, Pigmentation | 3 3 3 3 4 3 3 4 4 3 | 10 3.3|
Transitional Epithelium, Hyperplasia | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Inflammation, Subacute | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
Metaplasia, Squamous | 4 3 4 4 4 4 2 4 4 4 | 10 3.7|
Wall, Proliferation Connective Tissue| 3 2 3 3 3 2 2 3 3 2 | 10 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7| | |
| 4| 4| 5| 5| 5| 3| 5| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 3 |
Parasite Metazoan | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Inflammation, Granulomatous, Multiple| 2 2 3 2 2 1 2 1 2 2 | 10 1.9|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 4 2 2 2 | 7 2.3|
Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
Congestion | 3 2 2 2 1 3 | 6 2.2|
Depletion Lymphoid | 3 2 | 2 2.5|
Hematopoietic Cell Proliferation | 3 2 2 3 2 3 | 6 2.5|
Pigmentation | 2 2 2 2 2 2 2 | 7 2.0|
Capsule, Hypertrophy | 3 2 2 2 2 3 3 2 3 2 | 10 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 3| 4| 4| 6| 7| | |
| 4| 4| 5| 5| 5| 3| 5| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.80% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Capsule, Inflammation, Chronic | 3 2 2 2 2 3 1 2 1 1 | 10 1.9|
__________________________________________________________________________|____________|
Thymus | + + | 2 |
Atrophy | 3 | 1 3.0|
Congestion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Hydronephrosis | 3 | 1 3.0|
Nephropathy, Chronic | 1 1 3 1 | 4 1.5|
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Mineralization | 1 1 1 | 3 1.0|
Renal Tubule, Mineralization | 1 1 1 3 2 1 2 | 7 1.6|
Renal Tubule, Pigmentation | 2 2 2 2 2 3 3 3 2 2 | 10 2.3|
Transitional Epithelium, Hyperplasia | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
Dilatation | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Subacute | 2 | 1 2.0|
Inflammation, Suppurative | 3 3 2 | 3 2.7|
Metaplasia, Squamous | 3 3 2 4 4 2 4 2 | 8 3.0|
Wall, Proliferation Connective Tissue| 2 3 3 2 3 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 0| 2| 2| 3| 3| | |
DAY ON TEST | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3| | |
| 5| 7| 5| 5| 6| 4| 1| 8| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 9 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 9 |
Autolysis | 1 | 1 1.0|
Intussusception | X | 1 |
Necrosis | 2 | 1 2.0|
Proliferation Connective Tissue | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 9 |
Autolysis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Inflammation, Granulomatous, Multiple| 2 2 2 1 2 1 2 2 2 | 9 1.8|
Hepatocyte, Hypertrophy | 1 | 1 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 2 1 1 1 2 2 2 2 2 | 10 1.6|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
Acinus, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 3 4 4 4 | 4 3.8|
Dilatation | 4 1 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 5 |
Iliac, Hyperplasia, Lymphoid | 3 3 3 | 3 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 0| 2| 2| 3| 3| | |
DAY ON TEST | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3| | |
| 5| 7| 5| 5| 6| 4| 1| 8| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 4 3 2 | 6 2.5|
Depletion Lymphoid | 1 2 3 2 3 1 | 6 2.0|
Hematopoietic Cell Proliferation | 3 2 2 2 | 4 2.3|
Pigmentation | 2 2 3 2 | 4 2.3|
Capsule, Hypertrophy | 3 3 2 2 2 3 3 3 2 | 9 2.6|
Capsule, Inflammation, Chronic | 3 2 2 2 3 3 2 3 2 | 9 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Hydronephrosis | 3 2 2 | 3 2.3|
Pelvis, Mineralization | 1 1 1 1 | 4 1.0|
Pelvis, Necrosis | 2 | 1 2.0|
Renal Tubule, Mineralization | 1 2 1 1 1 | 5 1.2|
Renal Tubule, Pigmentation | 2 2 2 2 2 1 2 2 2 2 | 10 1.9|
Renal Tubule, Regeneration | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 3 2 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
Dilatation | 3 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Hemorrhage | 3 4 | 2 3.5|
Inflammation, Suppurative | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 0| 2| 2| 3| 3| | |
DAY ON TEST | 6| 1| 4| 4| 4| 8| 8| 9| 0| 3| | |
| 5| 7| 5| 5| 6| 4| 1| 8| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Metaplasia, Squamous | 3 2 4 3 4 4 4 4 | 8 3.5|
Wall, Proliferation Connective Tissue| 3 2 2 4 4 | 5 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7| | |
DAY ON TEST | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2| | |
| 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | 2 2 | 2 2.0|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 | 9 2.0|
Eosinophilic Focus | 2 | 1 2.0|
Eosinophilic Focus, Multiple | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 3 2 3 | 3 2.7|
Inflammation, Granulomatous, Multiple| 1 1 1 2 3 1 2 2 1 1 | 10 1.5|
Mixed Cell Focus | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 | 2 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis, Focal | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 9 |
Edema | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 2 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
Inflammation, Chronic | 3 | 1 3.0|
Mineralization, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7| | |
DAY ON TEST | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2| | |
| 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
Duct, Cyst | 3 X 2 2 3 | 5 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 2 | 1 2.0|
Dilatation | 2 2 | 2 2.0|
Cervix, Myometrium, Hypertrophy | 4 3 | 2 3.5|
Endometrium, Hyperplasia, Cystic | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 16 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Angiectasis | 3 3 2 3 3 2 2 2 3 | 9 2.6|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Pigmentation | 2 3 | 2 2.5|
Pancreatic, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 3 3 | 2 3.0|
Congestion | 2 2 2 2 2 2 2 | 7 2.0|
Depletion Lymphoid | 3 3 2 1 2 | 5 2.2|
Hematopoietic Cell Proliferation | 2 3 2 3 2 2 2 3 2 3 3 2 | 12 2.4|
Hyperplasia, Histiocytic, Lymphoid | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation | 2 3 2 3 2 2 2 2 2 2 3 2 | 12 2.3|
Capsule, Hypertrophy | 2 2 1 1 1 1 2 2 1 | 9 1.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
Hyperplasia, Lobular | 3 | 1 3.0|
Duct, Cyst | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 6| 6| 4| 4| 6| 7| 7| 4| 4| 6| 6| 7| 4| 5| 5| 6| 7| | |
DAY ON TEST | 1| 5| 2| 3| 6| 7| 7| 6| 2| 2| 2| 5| 3| 3| 2| 2| 0| 5| 0| 2| | |
| 1| 9| 1| 9| 2| 6| 7| 8| 9| 9| 4| 2| 2| 9| 9| 1| 4| 2| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 3 |
Calvarium, Hyperostosis | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
Hydrocephalus | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Hydronephrosis | 4 4 | 2 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Nephropathy, Chronic | 1 3 1 1 2 2 1 1 1 1 3 3 | 12 1.7|
Bilateral, Hydronephrosis | 4 | 1 4.0|
Papilla, Necrosis | 4 4 | 2 4.0|
Pelvis, Hemorrhage | 4 | 1 4.0|
Pelvis, Inflammation, Suppurative | 3 | 1 3.0|
Pelvis, Mineralization | 1 1 1 1 | 4 1.0|
Renal Tubule, Mineralization | 2 1 3 1 1 1 1 1 1 | 9 1.3|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 | 20 1.1|
Renal Tubule, Regeneration | 3 4 | 2 3.5|
Transitional Epithelium, Hyperplasia | 1 1 2 1 3 | 5 1.6|
__________________________________________________________________________|____________|
Ureter | + + + M M + M + + + + + + + + + + + + + | 17 |
Dilatation | 2 2 2 3 3 | 5 2.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemorrhage | 4 3 | 2 3.5|
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Squamous | 3 2 4 3 4 3 | 6 3.2|
Necrosis | 3 3 4 | 3 3.3|
Transitional Epithelium, Hyperplasia | 3 3 3 3 | 4 3.0|
Wall, Infiltration Cellular, Lipocyte| 3 2 4 | 3 3.0|
Wall, Proliferation Connective Tissue| 4 2 4 4 3 2 4 4 2 3 3 | 11 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 7| 8| 8| 7| 7| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatocyte, Necrosis, Multifocal | 1 1 1 | 3 1.0|
Kupffer Cell, Pigmentation, | | |
Multifocal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 3 3 4 3 3 2 2 2 2 4 | 10 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 3 3 2 3 3 3 2 | 10 2.5|
Pigmentation | 3 3 3 2 3 3 3 3 3 3 | 10 2.9|
Capsule, Hypertrophy | 1 2 2 1 2 1 2 2 1 1 | 10 1.5|
Capsule, Inflammation, Chronic | 2 1 3 1 2 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 7| 8| 8| 7| 7| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Corticomedullary Junction, | | |
Mineralization | 1 1 2 1 1 2 2 2 1 | 9 1.4|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 1 2 | 10 1.9|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.600% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | X | 1 |
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 2 3 2 2 3 3 2 2 2 2 | 10 2.3|
Cervix, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 2 3 2 2 2 2 3 | 10 2.2|
Pigmentation | 2 3 3 3 2 3 3 3 3 2 | 10 2.7|
Capsule, Hypertrophy | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
Capsule, Inflammation, Chronic | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.600% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 | 2 2.0|
Inflammation, Chronic, Multifocal | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Mineralization | 1 1 1 1 | 4 1.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Inflammation, Subacute | 1 2 2 2 2 | 5 1.8|
Transitional Epithelium, Hyperplasia | 3 3 3 3 3 2 3 3 2 2 | 10 2.7|
Transitional Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
Wall, Proliferation Connective Tissue| 1 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 5| 5| 5| 5| 4| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.600% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 | 2 1.0|
Inflammation, Granulomatous, Multiple| 1 1 1 1 1 | 5 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 3 2 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 2 2 2 2 2 2 2 1 2 | 10 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hypertrophy | 1 | 1 1.0|
Pigmentation | 2 3 2 3 2 2 2 3 3 2 | 10 2.4|
Capsule, Hypertrophy | 1 2 1 2 2 1 1 2 | 8 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 5| 5| 5| 5| 4| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.600% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 3 1 1 | 3 1.7|
Pelvis, Inflammation, Suppurative | 2 | 1 2.0|
Pelvis, Mineralization | 1 | 1 1.0|
Renal Tubule, Mineralization | 2 1 2 1 1 1 1 1 | 8 1.3|
Renal Tubule, Pigmentation | 1 2 2 2 1 1 1 1 1 1 | 10 1.3|
Renal Tubule, Regeneration | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + | 9 |
Transitional Epithelium, Hyperplasia | 3 3 2 1 3 2 3 1 2 | 9 2.2|
Wall, Proliferation Connective Tissue| 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 6| 6| 5| 5| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + M + + + + + + + | 9 |
Basophilic Focus | 1 | 1 1.0|
Basophilic Focus, Multiple | 1 1 | 2 1.0|
Inflammation, Granulomatous, Multiple| 2 1 1 2 | 4 1.5|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Fat, Inflammation, Chronic | 3 2 3 2 | 4 2.5|
Fat, Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Mediastinal, Angiectasis | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 5| 5| 5| 6| 6| 5| 5| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | 2 2 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 | 8 2.0|
Pigmentation | 2 2 2 2 3 3 3 | 7 2.4|
Capsule, Hypertrophy | 1 1 2 2 2 2 1 2 1 | 9 1.6|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 1 1 1 2 1 | 5 1.2|
Pelvis, Mineralization | 1 1 | 2 1.0|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | 3 | 1 3.0|
Renal Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Squamous | 2 2 | 2 2.0|
Necrosis | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 3 3 | 3 3.0|
Wall, Proliferation Connective Tissue| 2 2 4 2 3 2 | 6 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2| | |
| 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | 2 | 1 2.0|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 | 8 2.0|
Clear Cell Focus | 2 | 1 2.0|
Clear Cell Focus, Multiple | 2 1 2 2 | 4 1.8|
Degeneration, Cystic | 3 | 1 3.0|
Eosinophilic Focus | 2 2 2 2 2 | 5 2.0|
Eosinophilic Focus, Multiple | 2 2 | 2 2.0|
Hepatodiaphragmatic Nodule | 2 4 | 2 3.0|
Hyperplasia, Nodular | 2 2 2 3 3 | 5 2.4|
Inflammation, Granulomatous, Multiple| 1 2 1 1 | 4 1.3|
Mixed Cell Focus | 3 | 1 3.0|
Mixed Cell Focus, Multiple | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Bile Duct, Hyperplasia | 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2 | 20 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis, Focal | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
Polyarteritis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 3 |
Inflammation, Suppurative | 4 | 1 4.0|
Ulcer | 2 4 | 2 3.0|
Ulcer, Multiple | 2 | 1 2.0|
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 3 |
Erosion, Multiple | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 4 |
Inflammation, Chronic | 2 3 3 2 | 4 2.5|
Atrium, Congestion | 4 | 1 4.0|
Atrium, Dilatation | 2 | 1 2.0|
Atrium, Thrombosis | 4 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2| | |
| 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
Depletion Cellular | 4 2 4 3 4 4 4 2 4 4 4 3 3 3 3 4 4 | 17 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 6 |
Atrophy | 3 3 | 2 3.0|
Inflammation, Suppurative | 3 4 | 2 3.5|
Necrosis | 4 | 1 4.0|
Duct, Cyst | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
Atrophy | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Hyperplasia | 2 2 | 2 2.0|
Seminiferous Tubule, Atrophy | 2 1 4 4 4 1 3 4 4 4 3 4 4 4 4 4 3 4 4 4 | 20 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 13 |
Deep Cervical, Angiectasis | 3 | 1 3.0|
Mediastinal, Angiectasis | 2 3 | 2 2.5|
Mediastinal, Hemorrhage | 4 2 | 2 3.0|
Pancreatic, Angiectasis | 2 | 1 2.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Renal, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 2 1 3 3 2 | 5 2.2|
Depletion Lymphoid | 1 | 1 1.0|
Fibrosis, Focal | 3 | 1 3.0|
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 2| 2| 2| 9| 4| 2| 2| 2| 8| 2| 2| 2| 2| 0| 0| 2| 2| 2| | |
| 4| 9| 8| 9| 9| 0| 8| 9| 9| 9| 2| 8| 9| 9| 9| 1| 7| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 3 2 2 2 2 2 2 2 | 9 2.1|
Inflammation, Granulomatous | 2 | 1 2.0|
Pigmentation | 2 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
Compression | 3 4 | 2 3.5|
Hemorrhage, Multiple | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 7 |
Inflammation, Granulomatous | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Alveolus, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 1 |
Lumen, Hyperkeratosis | 4 | 1 4.0|
Lumen, Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy, Chronic | 2 2 3 4 4 2 3 3 2 3 2 4 4 3 3 3 3 3 4 3 | 20 3.0|
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 16 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 | 19 1.1|
Transitional Epithelium, Hyperplasia | 2 2 1 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Ureter | + M + + + + + + + + + + M + + + + + + + | 18 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 8| 8| 8| 8| 7| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | 2 2 | 2 2.0|
Necrosis, Focal | 1 | 1 1.0|
Hepatocyte, Necrosis, Multiple | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 1 2 2 2 2 1 1 1 1 1 | 10 1.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 8| 8| 8| 8| 7| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 1 1 | 2 1.0|
Nephropathy | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Ureter | + + + + + M + + + + | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 1| 1| 0| 0| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Degeneration, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 1 1 1 1 | 4 1.0|
Renal Tubule, Pigmentation | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 1| 1| 0| 0| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 5| 4| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A |
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Inflammation, Granulomatous, Multiple| 1 1 1 | 3 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 3 2 2 2 3 3 2 2 3 3 | 10 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 5| 4| 4| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A |
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 1 1 1 2 2 1 2 2 1 | 10 1.5|
Pelvis, Mineralization | 1 1 1 1 | 4 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 2 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | |
| 5| 5| 5| 6| 6| 0| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 1 | 3 1.0|
Basophilic Focus, Multiple | 1 | 1 1.0|
Clear Cell Focus | 1 | 1 1.0|
Eosinophilic Focus | 1 | 1 1.0|
Inflammation, Granulomatous, Multiple| 1 1 1 2 2 1 1 | 7 1.3|
Vacuolization Cytoplasmic | 1 2 1 1 | 4 1.3|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 1 2 | 9 1.2|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis, Focal | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | M | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
Atrium, Congestion | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | |
| 5| 5| 5| 6| 6| 0| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 3 2 1 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 2 2 2 2 | 7 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 | 4 2.0|
Pigmentation | 2 3 2 2 3 2 2 | 7 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + | 2 |
Epidermis, Fibrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 2 1 2 2 1 2 1 1 1 | 10 1.5|
Pelvis, Inflammation, Suppurative | 2 | 1 2.0|
Pelvis, Mineralization | 1 1 1 | 3 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2| | |
DAY ON TEST | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7| | |
| 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 18 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 18 |
Hemorrhage | 3 4 | 2 3.5|
Intussusception | X X X X | 4 |
Parasite Metazoan | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 3 3 3 | 4 3.0|
Serosa, Inflammation, Chronic | 3 | 1 3.0|
Wall, Proliferation Connective Tissue| 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 18 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Eosinophilic Focus | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 3 | 1 3.0|
Inflammation, Granulomatous, Multiple| 2 2 2 1 2 1 2 2 | 8 1.8|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Hepatocyte, Hypertrophy | 1 1 | 2 1.0|
Hepatocyte, Necrosis, Multifocal | 3 | 1 3.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 3 1 1 1 2 2 2 2 1 2 2 2 1 2 2 1 2 2 | 18 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2| | |
DAY ON TEST | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7| | |
| 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
Depletion Cellular | 3 4 4 4 2 | 5 3.4|
__________________________________________________________________________|____________|
Penis | M | |
__________________________________________________________________________|____________|
Prostate | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Seminiferous Tubule, Atrophy | 3 2 3 2 2 1 1 3 1 1 1 1 4 3 2 | 15 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
Bronchial, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 1 | 16 2.1|
Depletion Lymphoid | 1 3 2 3 2 1 3 3 2 4 3 2 1 | 13 2.3|
Fibrosis | 2 2 2 | 3 2.0|
Hematopoietic Cell Proliferation | 3 3 3 2 4 3 1 | 7 2.7|
Pigmentation | 2 1 2 2 2 3 2 3 3 3 2 2 | 12 2.3|
Capsule, Hypertrophy | 3 2 2 2 3 3 3 3 3 2 2 3 3 3 2 3 3 3 3 2 | 20 2.7|
Capsule, Inflammation, Chronic | 3 2 2 1 1 2 3 3 3 2 2 3 2 3 2 2 3 4 2 2 | 20 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
Infiltration Cellular, Multifocal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 2| 2| 2| 2| | |
DAY ON TEST | 1| 7| 9| 9| 0| 2| 4| 5| 6| 9| 3| 4| 4| 6| 3| 5| 1| 1| 5| 7| | |
| 9| 7| 2| 8| 0| 8| 9| 6| 6| 8| 8| 2| 8| 8| 5| 8| 1| 7| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Hydronephrosis | 4 4 3 4 3 | 5 3.6|
Infarct | 2 4 2 | 3 2.7|
Nephropathy, Chronic | 2 2 2 1 1 2 2 2 2 1 1 2 2 2 | 14 1.7|
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Dilatation | 3 | 1 3.0|
Pelvis, Mineralization | 1 1 1 2 2 2 1 1 1 2 1 1 1 | 13 1.3|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Mineralization | 2 2 | 2 2.0|
Renal Tubule, Necrosis | 4 | 1 4.0|
Renal Tubule, Pigmentation | 3 2 2 1 2 3 3 3 2 2 3 2 2 2 2 3 3 2 2 2 | 20 2.3|
Renal Tubule, Regeneration | 3 3 3 | 3 3.0|
Transitional Epithelium, Hyperplasia | 2 1 3 2 3 2 3 2 3 1 2 | 11 2.2|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + + | 20 |
Dilatation | 2 2 3 2 3 3 | 6 2.5|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemorrhage | 4 3 3 | 3 3.3|
Inflammation, Suppurative | 2 3 4 | 3 3.0|
Metaplasia, Squamous | 3 4 4 3 2 4 4 4 4 2 3 4 3 2 3 4 3 3 | 18 3.3|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
Wall, Proliferation Connective Tissue| 3 3 4 3 3 2 3 2 3 4 4 2 2 4 4 | 15 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 7| 8| 8| 7| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.80% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatocyte, Hypertrophy | 2 2 2 2 3 2 2 2 3 2 | 10 2.2|
Hepatocyte, Necrosis, Multifocal | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Multifocal | 2 1 1 | 3 1.3|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 2 2 2 2 2 2 1 2 | 10 1.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Depletion Cellular | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 3 2 2 2 2 2 2 3 | 9 2.2|
Degeneration | 2 4 2 3 1 3 3 3 2 3 | 10 2.6|
Edema | 2 2 2 2 2 2 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Depletion Lymphoid | 3 2 3 3 3 3 3 3 3 3 | 10 2.9|
Pigmentation | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
Capsule, Hypertrophy | 3 3 3 2 2 3 3 2 2 2 | 10 2.5|
Capsule, Inflammation, Chronic | 3 3 2 3 3 3 3 2 3 3 | 10 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 7| 7| 8| 8| 7| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.80% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 2 1 2 2 2 1 | 7 1.7|
Renal Tubule, Pigmentation | 3 3 3 4 3 4 4 3 3 3 | 10 3.3|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Inflammation, Subacute | 2 2 2 1 2 2 2 2 2 3 | 10 2.0|
Metaplasia, Squamous | 3 3 4 3 4 3 4 4 2 4 | 10 3.4|
Transitional Epithelium, Hyperplasia | 3 4 4 3 4 4 4 4 4 | 9 3.8|
Wall, Proliferation Connective Tissue| 3 2 2 2 2 2 2 2 2 2 | 10 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 1| 1| 1| 0| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 3 |
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Granulomatous, Multiple| 2 | 1 2.0|
Hepatocyte, Hypertrophy | 2 3 3 2 2 3 3 3 2 3 | 10 2.6|
Hepatocyte, Necrosis, Multifocal | 2 2 2 2 2 1 2 2 1 2 | 10 1.8|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 2 1 | 6 1.3|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Depletion Cellular | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 3 2 3 3 2 3 2 3 3 | 10 2.7|
Degeneration | 2 2 2 3 2 2 3 2 3 3 | 10 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 4 4 4 3 4 4 4 4 4 4 | 10 3.9|
Depletion Lymphoid | 3 4 4 3 3 3 3 4 3 2 | 10 3.2|
Fibrosis | 2 2 | 2 2.0|
Pigmentation | 2 2 2 1 2 2 2 2 | 8 1.9|
Capsule, Hypertrophy | 3 4 4 3 3 3 3 3 3 3 | 10 3.2|
Capsule, Inflammation, Chronic | 2 3 3 3 3 3 3 2 2 2 | 10 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 1| 1| 1| 0| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
1.80% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 1 2 2 1 2 2 2 2 2 | 10 1.8|
Pigmentation | 4 | 1 4.0|
Pelvis, Mineralization | 3 | 1 3.0|
Renal Tubule, Mineralization | 1 | 1 1.0|
Renal Tubule, Pigmentation | 3 3 3 3 3 3 3 3 3 | 9 3.0|
Renal Tubule, Regeneration | 2 2 2 2 1 2 2 2 2 2 | 10 1.9|
Transitional Epithelium, Hyperplasia | 2 1 3 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Ureter | M + + + + + + + + + | 9 |
Transitional Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Cyst, Multiple | X | 1 |
Inflammation, Subacute | 2 2 2 2 2 3 2 | 7 2.1|
Metaplasia, Squamous | 3 4 3 4 4 4 4 2 4 4 | 10 3.6|
Wall, Proliferation Connective Tissue| 3 3 2 2 3 4 4 3 3 | 9 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| | |
| 8| 3| 4| 5| 5| 7| 2| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.80% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
Parasite Metazoan | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Cyst | X | 1 |
Eosinophilic Focus, Multiple | 1 | 1 1.0|
Inflammation, Granulomatous, Multiple| 2 2 2 2 2 2 2 2 | 8 2.0|
Hepatocyte, Hypertrophy | 1 | 1 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 1 1 2 1 1 2 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
Epithelium, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Depletion Cellular | 4 2 1 | 3 2.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Seminiferous Tubule, Atrophy | 1 2 1 1 2 | 5 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 2 2 3 3 3 | 6 2.7|
Depletion Lymphoid | 2 3 | 2 2.5|
Hematopoietic Cell Proliferation | 3 3 2 3 2 2 | 6 2.5|
Pigmentation | 2 1 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 6| 7| 7| 7| 4| 7| 7| 7| 7| | |
| 8| 3| 4| 5| 5| 7| 2| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.80% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thrombosis | X | 1 |
Capsule, Hypertrophy | 3 2 2 2 2 3 3 2 2 3 | 10 2.4|
Capsule, Inflammation, Chronic | 2 3 2 2 2 1 1 1 1 2 | 10 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Fibrosis | 3 | 1 3.0|
Hydronephrosis | 2 4 1 4 | 4 2.8|
Nephropathy, Chronic | 2 2 2 2 2 2 2 1 2 | 9 1.9|
Pelvis, Dilatation | 2 | 1 2.0|
Pelvis, Mineralization | 1 2 | 2 1.5|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Pigmentation | 2 2 3 1 2 2 2 2 1 2 | 10 1.9|
Renal Tubule, Regeneration | 2 3 2 3 | 4 2.5|
Transitional Epithelium, Hyperplasia | 2 3 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
Dilatation | 1 2 3 3 | 4 2.3|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Hemorrhage | 4 3 | 2 3.5|
Inflammation, Subacute | 3 2 2 | 3 2.3|
Inflammation, Suppurative | 3 3 3 | 3 3.0|
Metaplasia, Squamous | 4 2 3 2 4 2 | 6 2.8|
Wall, Proliferation Connective Tissue| 3 2 4 2 2 4 3 | 7 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9| | |
| 0| 6| 8| 3| 9| 6| 9| 2| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 9 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 9 |
Hemorrhage | 4 2 | 2 3.0|
Intussusception | X X | 2 |
Necrosis | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 4 4 3 4 | 5 3.6|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Granulomatous, Multiple| 1 1 3 2 1 | 5 1.6|
Hepatocyte, Hypertrophy | 2 1 2 | 3 1.7|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 2 2 2 2 1 2 2 2 | 8 1.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Depletion Cellular | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + | 4 |
Inflammation, Suppurative | 4 4 | 2 4.0|
Proliferation Connective Tissue | 4 | 1 4.0|
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Seminiferous Tubule, Atrophy | 1 2 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9| | |
| 0| 6| 8| 3| 9| 6| 9| 2| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 2 2 2 | 6 2.0|
Depletion Lymphoid | 4 3 2 1 3 | 5 2.6|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 4 2 2 | 4 2.8|
Inflammation, Chronic | 2 | 1 2.0|
Pigmentation | 3 3 2 2 2 | 5 2.4|
Capsule, Hypertrophy | 4 3 2 3 2 3 3 2 2 2 | 10 2.6|
Capsule, Inflammation, Chronic | 3 2 2 2 1 3 2 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Thymus | + + | 2 |
Atrophy | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Hydronephrosis | 4 4 3 | 3 3.7|
Nephropathy, Chronic | 2 2 2 1 2 1 1 | 7 1.6|
Bilateral, Hydronephrosis | 4 | 1 4.0|
Pelvis, Mineralization | 1 2 1 1 1 1 2 | 7 1.3|
Pelvis, Necrosis | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 3 2 2 2 3 3 2 2 1 | 10 2.2|
Renal Tubule, Regeneration | 2 | 1 2.0|
Transitional Epithelium, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 3| 1| 3| 4| 6| 8| 9| | |
| 0| 6| 8| 3| 9| 6| 9| 2| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.80% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Transitional Epithelium, Hyperplasia | 2 2 3 2 3 3 3 | 7 2.6|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
Dilatation | 3 2 2 3 3 | 5 2.6|
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Hemorrhage | 3 | 1 3.0|
Metaplasia, Squamous | 2 3 2 4 4 4 4 3 3 3 | 10 3.2|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
Wall, Proliferation Connective Tissue| 3 3 4 3 2 4 | 6 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6| | |
DAY ON TEST | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8| | |
| 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
Edema | 2 3 | 2 2.5|
Parasite Metazoan | 2 | 1 2.0|
Submucosa, Proliferation Connective | | |
Tissue | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
Edema | 3 | 1 3.0|
Fibrosis | 3 | 1 3.0|
Hemorrhage | 3 4 | 2 3.5|
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | 2 1 | 2 1.5|
Basophilic Focus, Multiple | 1 1 2 | 3 1.3|
Clear Cell Focus | 2 | 1 2.0|
Eosinophilic Focus | 2 2 | 2 2.0|
Eosinophilic Focus, Multiple | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Hepatodiaphragmatic Nodule | 3 | 1 3.0|
Inflammation, Granulomatous, Multiple| 1 2 1 2 1 1 | 6 1.3|
Mixed Cell Focus | 2 | 1 2.0|
Thrombosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 1 2 | 2 1.5|
Bile Duct, Hyperplasia | 2 1 1 1 2 2 2 | 7 1.6|
Centrilobular, Degeneration | 3 | 1 3.0|
Hepatocyte, Necrosis, Multiple | 3 | 1 3.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 | 1 1.0|
Serosa, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 4 |
Edema | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6| | |
DAY ON TEST | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8| | |
| 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Atrophy | 2 | 1 2.0|
Acinar Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 9 |
Abscess | 4 1 | 2 2.5|
Edema | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 3 4 3 | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 9 |
Mineralization | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + | 2 |
Inflammation, Chronic | 2 2 | 2 2.0|
Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
Vacuolization Cytoplasmic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
Hyperplasia | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
Depletion Cellular | 3 4 4 2 4 4 4 4 2 4 3 4 | 12 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 6 |
Atrophy | 3 3 3 | 3 3.0|
Hyperplasia | 3 | 1 3.0|
Duct, Cyst | 3 2 2 3 | 4 2.5|
Duct, Cyst, Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6| | |
DAY ON TEST | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8| | |
| 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 1 1 | 9 1.8|
Seminiferous Tubule, Atrophy | 3 4 4 3 4 4 4 3 4 3 4 4 4 | 13 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 14 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Angiectasis | 3 2 3 | 3 2.7|
Mediastinal, Congestion | 3 | 1 3.0|
Mediastinal, Pigmentation | 2 2 3 | 3 2.3|
Pancreatic, Angiectasis | 2 | 1 2.0|
Pancreatic, Edema | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Angiectasis | 3 | 1 3.0|
Renal, Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 7 |
Hyperplasia, Lymphoid | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 8 |
Angiectasis | 3 2 | 2 2.5|
Congestion | 2 | 1 2.0|
Cyst | 3 3 | 2 3.0|
Edema | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Congestion | 2 2 2 2 2 2 2 2 2 3 2 | 11 2.1|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 3 2 4 2 3 2 2 2 2 2 2 3 | 14 2.4|
Pigmentation | 2 2 3 2 2 2 2 2 2 2 3 | 11 2.2|
Capsule, Hypertrophy | 2 1 2 2 2 1 2 3 1 | 9 1.8|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
Calvarium, Hyperostosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 4| 6| 6| 7| 4| 5| 5| 6| 6| 2| 3| 4| 4| 4| 4| 6| 6| 6| 6| | |
DAY ON TEST | 7| 2| 1| 3| 2| 5| 1| 8| 4| 4| 0| 5| 1| 2| 3| 8| 1| 1| 3| 8| | |
| 5| 9| 8| 6| 9| 7| 2| 2| 6| 8| 7| 1| 3| 3| 4| 0| 2| 7| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Nephropathy, Chronic | 2 3 3 4 3 2 3 2 4 4 3 2 3 2 2 4 2 2 4 4 | 20 2.9|
Cortex, Cyst | 4 | 1 4.0|
Pelvis, Mineralization | 3 3 3 2 3 3 3 3 2 3 2 3 3 3 3 3 3 2 2 2 | 20 2.7|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Pigmentation | 1 1 2 1 2 1 1 3 2 1 2 1 1 1 1 1 1 2 1 1 | 20 1.4|
Transitional Epithelium, Hyperplasia | 2 2 2 2 2 1 3 2 2 3 2 2 2 1 2 2 2 2 2 2 | 20 2.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + + | 20 |
Dilatation | 2 2 2 | 3 2.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + + | 2 |
Bulbourethral Gland, Cyst, Multiple | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemorrhage | 3 | 1 3.0|
Metaplasia, Squamous | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 3 2 2 2 3 3 | 6 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 8| 8| 8| 8| 7| 7| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
0.600% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Granulomatous, Multiple| 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 3 2 3 2 3 3 3 3 | 9 2.8|
Pigmentation | 3 3 3 3 3 3 3 2 3 3 | 10 2.9|
Capsule, Hypertrophy | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 7| 8| 8| 8| 8| 7| 7| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
0.600% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
3 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 2 1 2 2 2 2 2 2 2 | 10 1.9|
Pelvis, Mineralization | 2 2 2 2 2 1 2 2 1 | 9 1.8|
Renal Tubule, Degeneration | 3 3 3 3 3 3 3 2 3 3 | 10 2.9|
Renal Tubule, Necrosis | 2 3 3 3 2 2 3 2 3 3 | 10 2.6|
Renal Tubule, Pigmentation | 1 2 1 1 2 2 2 2 2 | 9 1.7|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 1| 1| 0| 0| 0| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Artery, Inflammation, Chronic, Focal | 3 | 1 3.0|
Hepatocyte, Necrosis, Multifocal | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 | 3 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 3 3 3 2 2 3 2 3 2 | 10 2.5|
Pigmentation | 3 2 2 3 2 3 3 3 3 2 | 10 2.6|
Capsule, Hypertrophy | 2 2 2 2 2 2 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 0| 0| 0| 1| 1| 0| 0| 0| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.600% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
6 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 | 2 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 3 2 3 2 2 2 2 3 2 2 | 10 2.3|
Pigmentation | 2 | 1 2.0|
Renal Tubule, Mineralization | 3 3 3 3 2 3 2 3 2 2 | 10 2.6|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 | 9 2.0|
Renal Tubule, Regeneration | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Transitional Epithelium, Hyperplasia | 2 2 3 3 2 3 3 3 3 2 | 10 2.6|
Wall, Proliferation Connective Tissue| 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 5| 4| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.600% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 | 1 1.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 | 1 2.0|
Inflammation, Granulomatous, Multiple| 2 1 1 1 1 2 2 1 2 | 9 1.4|
Vacuolization Cytoplasmic | 3 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Interstitial Cell, Hyperplasia | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Pancreatic, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 2 2 2 3 2 2 3 | 10 2.2|
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Pigmentation | 3 2 3 2 2 2 2 2 2 3 | 10 2.3|
Capsule, Hypertrophy | 1 2 1 1 1 2 1 2 | 8 1.4|
Capsule, Inflammation, Chronic | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 5| 4| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.600% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
9 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 2 2 2 3 2 3 3 2 3 | 10 2.4|
Pelvis, Mineralization | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Transitional Epithelium, Hyperplasia | 2 2 2 2 2 1 2 | 7 1.9|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 3 2 3 2 2 4 3 1 2 | 9 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| | |
DAY ON TEST | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5| | |
| 5| 4| 4| 8| 6| 9| 9| 0| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Inflammation, Granulomatous, Multiple| 1 1 1 2 1 1 2 1 2 | 9 1.3|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + | 3 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Adventitia, Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 2 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
Iliac, Angiectasis | 3 | 1 3.0|
Renal, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| | |
DAY ON TEST | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5| | |
| 5| 4| 4| 8| 6| 9| 9| 0| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | X | 1 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 2 2 2 2 | 5 2.2|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 | 7 2.0|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
Pigmentation | 2 2 2 2 3 | 5 2.2|
Capsule, Hypertrophy | 1 1 1 1 1 1 1 1 | 8 1.0|
Capsule, Inflammation, Chronic | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Congestion | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 2 3 3 4 2 2 3 2 3 | 10 2.6|
Bilateral, Hydronephrosis | 3 3 | 2 3.0|
Pelvis, Dilatation | 2 | 1 2.0|
Pelvis, Mineralization | 3 3 3 3 3 3 3 3 4 3 | 10 3.1|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 2 1 | 9 1.1|
Renal Tubule, Regeneration | 2 2 3 | 3 2.3|
Transitional Epithelium, Hyperplasia | 2 3 3 2 2 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Ureter | + + + M + + + M + + | 8 |
Dilatation | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05092-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SPECIAL STUDY O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:37:22
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| | |
DAY ON TEST | 0| 6| 2| 2| 5| 2| 2| 3| 5| 5| | |
| 5| 4| 4| 8| 6| 9| 9| 0| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.600% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Metaplasia, Squamous | 4 3 | 2 3.5|
Transitional Epithelium, Hyperplasia | 3 2 2 2 | 4 2.3|
Wall, Proliferation Connective Tissue| 4 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
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---------- END OF REPORT ----------
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