TDMS Study 05092-03 Pathology Tables
TP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Southern Research Inst O-NITROANISOLE DATE: 04/11/97 EXPERIMENT: 05092 TEST: 03 TIME: 14:59:55 TEST TYPE: SPECIAL STUDY CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B PATHOLOGIST: R. THOMPSON CAS: 0091-23-6 ------------------------------------------------------------------------------------------------------------------------------------ Core Animals REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: EXCLUDE 002 0.0% 3 SSAC EXCLUDE 003 0.0% 6 SSAC EXCLUDE 004 0.0% 9 SSAC EXCLUDE 005 0.0% 15 SSAC EXCLUDE 007 0.0% 3 SSAC EXCLUDE 008 0.0% 6 SSAC EXCLUDE 009 0.0% 9 SSAC EXCLUDE 010 0.0% 15 SSAC EXCLUDE 012 1.80% 3 SSAC EXCLUDE 013 1.80% 6 SSAC EXCLUDE 014 1.80% 9 SSAC EXCLUDE 015 1.80% 15 SSAC EXCLUDE 017 1.80% 3 SSAC EXCLUDE 018 1.80% 6 SSAC EXCLUDE 019 1.80% 9 SSAC EXCLUDE 020 1.80% 15 SSAC EXCLUDE 022 0.600% 3 SSAC EXCLUDE 023 0.600% 6 SSAC EXCLUDE 024 0.600% 9 SSAC EXCLUDE 025 0.600% 15 SSAC EXCLUDE 027 0.600% 3 SSAC EXCLUDE 028 0.600% 6 SSAC EXCLUDE 029 0.600% 9 SSAC EXCLUDE 030 0.600% 15 SSAC EXCLUDE 031 SENTINEL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Southern Research Inst O-NITROANISOLE DATE: 04/11/97 EXPERIMENT: 05092 TEST: 03 TIME: 14:59:55 TEST TYPE: SPECIAL STUDY CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B PATHOLOGIST: R. THOMPSON S. EUSTIS CAS: 0091-23-6 O-NITROANISOLE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 728 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0.0% | | --------------------- | | | | TOTAL 20 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 13 | | | | UNCENSORED DEATHS | | 564 582 590 639 648 701 707 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 0.600% | | --------------------- | | | | TOTAL 20 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 1 | | | | UNCENSORED DEATHS | | 207 275 351 413 423 429 434 457 480 512 | | 582 612 617 618 636 639 646 648 680 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 1.80% | | --------------------- | | | | TOTAL 20 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 0 | | | | UNCENSORED DEATHS | | 158 211 217 219 228 238 242 248 249 254 | | 256 266 268 277 277 292 298 298 300 335 | | CENSORED DEATHS | | NONE | | | ================================================================================== O-NITROANISOLE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 728 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 728 (A) | | | |--------------------------------------------------------------------------------| | | | |0.0% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 85.0 75.0 65.0 | | | | | | | |0.600% | 100.0 100.0 95.0 85.0 75.0 55.0 50.0 45.0 10.0 5.0 | | | | | | | |1.80% | 100.0 95.0 35.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0.0% 0.600% 1.80% | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 65.0% 5.0% 0.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 633.0 508.4 256.6 | |NATURAL DEATHS (C) | (21.6) (31.7) ( 8.9) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 694.8 519.4 256.6 | |(STANDARD ERROR) | (12.6) (32.0) ( 8.9) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) O-NITROANISOLE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 728 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0.0% | | --------------------- | | | | TOTAL 20 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 14 | | | | UNCENSORED DEATHS | | 103 421 590 648 662 679 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 0.600% | | --------------------- | | | | TOTAL 20 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 4 | | | | UNCENSORED DEATHS | | 311 359 421 421 424 452 476 477 504 552 | | 601 632 639 639 662 668 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 1.80% | | --------------------- | | | | TOTAL 20 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 0 | | | | UNCENSORED DEATHS | | 48 219 221 239 247 248 268 268 284 303 | | 307 307 309 324 327 333 336 340 408 425 | | CENSORED DEATHS | | NONE | | | ================================================================================== O-NITROANISOLE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 728 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 728 (A) | | | |--------------------------------------------------------------------------------| | | | |0.0% | 100.0 95.0 95.0 95.0 90.0 90.0 90.0 85.0 75.0 70.0 | | | | | | | |0.600% | 100.0 100.0 100.0 90.0 75.0 60.0 55.0 45.0 25.0 20.0 | | | | | | | |1.80% | 95.0 95.0 60.0 10.0 0.0 0.0 0.0 0.0 0.0 0.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0.0% 0.600% 1.80% | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 70.0% 20.0% 0.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P<0.001 P=0.002 P<0.001 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 517.2 514.9 288.1 | |NATURAL DEATHS (C) | (91.4) (28.7) (17.6) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 664.8 557.5 288.1 | |(STANDARD ERROR) | (33.9) (30.0) (17.6) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) O-NITROANISOLE KAPLAN-MEIER SURVIVAL CURVES 0.0% = 1 0.600% = 2 1.80% = 3 ------------------------------------------------------ SPECIES=RATS SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 3 2 1 | | 3 23 2 1 1 | 90 + 2 2 1 1 | | 33 2 2 1 1 | 80 + 33 2 2 11 | | 33 22 1 1 | P 70 + 3 3 E | R | 33 2 2 1 1 C | E 60 + 2 2 N | T | 33 2 2 | S 50 + 2 2 U | R | 33 2 2 V | I 40 + 33 22 V | A | 33 L | 30 + 2 2 | | 3 3 22 | 20 + 33 22 | | | 10 + 2 2 | | 3 3 2 2 | 0 + 3 | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 2 obs hidden. O-NITROANISOLE KAPLAN-MEIER SURVIVAL CURVES 0.0% = 1 0.600% = 2 1.80% = 3 ----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 3 1 2 | | 3 1 3 2 2 1 | 90 + 2 1 1 | | 3 3 1 1 | 80 + 33 1 1 | | 2 2 1 1 | P 70 + 3 3 2 2 1 1 E | R | 22 C | E 60 + 3 3 2 2 N | T | 3 3 2 2 | S 50 + 2 2 U | R | 2 2 V | I 40 + 3 3 22 V | A | 3 3 L | 30 + 2 2 | | 33 22 | 20 + 2 2 | | 33 | 10 + 3 3 | | 3 3 | 0 + 3 | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 3 obs hidden.