TDMS Study 05092-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROANISOLE DATE: 04/14/97
EXPERIMENT: 05092 TEST: 03 TIME: 11:59:52
TEST TYPE: SPECIAL STUDY CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B
PATHOLOGIST: R. THOMPSON CAS: 0091-23-6
------------------------------------------------------------------------------------------------------------------------------------
6 SSAC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: EXCLUDE 001 0.0%
EXCLUDE 002 0.0% 3 SSAC
EXCLUDE 004 0.0% 9 SSAC
EXCLUDE 005 0.0% 15 SSAC
EXCLUDE 006 0.0%
EXCLUDE 007 0.0% 3 SSAC
EXCLUDE 009 0.0% 9 SSAC
EXCLUDE 010 0.0% 15 SSAC
EXCLUDE 011 1.80%
EXCLUDE 012 1.80% 3 SSAC
EXCLUDE 014 1.80% 9 SSAC
EXCLUDE 015 1.80% 15 SSAC
EXCLUDE 016 1.80%
EXCLUDE 017 1.80% 3 SSAC
EXCLUDE 019 1.80% 9 SSAC
EXCLUDE 020 1.80% 15 SSAC
EXCLUDE 021 0.600%
EXCLUDE 022 0.600% 3 SSAC
EXCLUDE 024 0.600% 9 SSAC
EXCLUDE 025 0.600% 15 SSAC
EXCLUDE 026 0.600%
EXCLUDE 027 0.600% 3 SSAC
EXCLUDE 029 0.600% 9 SSAC
EXCLUDE 030 0.600% 15 SSAC
EXCLUDE 031 SENTINEL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROANISOLE DATE: 04/14/97
EXPERIMENT: 05092 TEST: 03 TIME: 11:59:52
TEST TYPE: SPECIAL STUDY CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B
PATHOLOGIST: R. THOMPSON S. EUSTIS CAS: 0091-23-6
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% 6 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 190 190 190 190 190 191 191 191 191 191 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.600% 6 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 190 190 190 190 190 190 191 191 191 191 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.80% 6 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 190 190 190 191 191 191 191 191 191 191 |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 1E5 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|6 SSAC | |
| | |
|0.600% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|6 SSAC | |
| | |
|1.80% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|6 SSAC | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.600% 1.80% |
| 6 SSAC 6 SSAC 6 SSAC |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 100.0% 100.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . . . |
|NATURAL DEATHS (C) | ( . ) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 190.5 190.4 190.7 |
|(STANDARD ERROR) | ( 0.2) ( 0.2) ( 0.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% 6 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 190 190 190 190 190 190 190 191 191 191 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.600% 6 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 190 190 191 191 191 191 191 191 191 191 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.80% 6 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 190 190 190 190 190 190 190 191 191 191 |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 1E5 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|6 SSAC | |
| | |
|0.600% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|6 SSAC | |
| | |
|1.80% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|6 SSAC | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.600% 1.80% |
| 6 SSAC 6 SSAC 6 SSAC |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 100.0% 100.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . . . |
|NATURAL DEATHS (C) | ( . ) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 190.3 190.8 190.3 |
|(STANDARD ERROR) | ( 0.2) ( 0.1) ( 0.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
0.0% 6 SSAC = 1
0.600% 6 SSAC = 2
1.80% 6 SSAC = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 4 obs hidden.)
P |
E |
R 200 +
C |
E |
N |
T 100 + 1 1
|
S |
U |
R 0 +
V |
I ---+----------------------------------------------------------------------------------+--
V 0 28
A
WEEK
O-NITROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
0.0% 6 SSAC = 1
0.600% 6 SSAC = 2
1.80% 6 SSAC = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 4 obs hidden.)
P |
E |
R 200 +
C |
E |
N |
T 100 + 1 1
|
S |
U |
R 0 +
V |
I ---+----------------------------------------------------------------------------------+--
V 0 28
A
WEEK