TDMS Study 05092-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROANISOLE DATE: 04/15/97
EXPERIMENT: 05092 TEST: 03 TIME: 12:00:15
TEST TYPE: SPECIAL STUDY CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B
PATHOLOGIST: R. THOMPSON CAS: 0091-23-6
------------------------------------------------------------------------------------------------------------------------------------
15 SSAC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: EXCLUDE 001 0.0%
EXCLUDE 002 0.0% 3 SSAC
EXCLUDE 003 0.0% 6 SSAC
EXCLUDE 004 0.0% 9 SSAC
EXCLUDE 006 0.0%
EXCLUDE 007 0.0% 3 SSAC
EXCLUDE 008 0.0% 6 SSAC
EXCLUDE 009 0.0% 9 SSAC
EXCLUDE 011 1.80%
EXCLUDE 012 1.80% 3 SSAC
EXCLUDE 013 1.80% 6 SSAC
EXCLUDE 014 1.80% 9 SSAC
EXCLUDE 016 1.80%
EXCLUDE 017 1.80% 3 SSAC
EXCLUDE 018 1.80% 6 SSAC
EXCLUDE 019 1.80% 9 SSAC
EXCLUDE 021 0.600%
EXCLUDE 022 0.600% 3 SSAC
EXCLUDE 023 0.600% 6 SSAC
EXCLUDE 024 0.600% 9 SSAC
EXCLUDE 026 0.600%
EXCLUDE 027 0.600% 3 SSAC
EXCLUDE 028 0.600% 6 SSAC
EXCLUDE 029 0.600% 9 SSAC
EXCLUDE 031 SENTINEL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROANISOLE DATE: 04/15/97
EXPERIMENT: 05092 TEST: 03 TIME: 12:00:15
TEST TYPE: SPECIAL STUDY CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B
PATHOLOGIST: R. THOMPSON CAS: 0091-23-6
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 1 CENSORED DEATHS 9 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 410 |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.600% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 7 CENSORED DEATHS 3 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 305 329 329 364 424 428 430 |
| CENSORED DEATHS |
| 455 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.80% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 210 216 218 233 236 249 262 287 298 319 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 1E5 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 90.0 90.0 90.0 90.0 90.0 90.0 |
|15 SSAC | |
| | |
|0.600% | 100.0 100.0 100.0 60.0 50.0 30.0 30.0 30.0 30.0 30.0 |
|15 SSAC | |
| | |
|1.80% | 100.0 100.0 30.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.600% 1.80% |
| 15 SSAC 15 SSAC 15 SSAC |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 90.0% 30.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.020 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 410.0 372.7 252.8 |
|NATURAL DEATHS (C) | ( . ) (20.4) (11.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 450.9 397.6 252.8 |
|(STANDARD ERROR) | ( 4.5) (18.8) (11.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 8 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 408 413 |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.600% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 455 455 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.80% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 84 265 281 298 309 317 336 345 345 346 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 1E5 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 80.0 80.0 80.0 80.0 80.0 80.0 |
|15 SSAC | |
| | |
|0.600% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|15 SSAC | |
| | |
|1.80% | 90.0 90.0 80.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.600% 1.80% |
| 15 SSAC 15 SSAC 15 SSAC |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 100.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.456N P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 410.5 . 292.6 |
|NATURAL DEATHS (C) | ( 2.5) ( . ) (24.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 446.4 455.5 292.6 |
|(STANDARD ERROR) | ( 6.0) ( 0.2) (24.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
0.0% 15 SSAC = 1
0.600% 15 SSAC = 2
1.80% 15 SSAC = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
|
|
|
90 + 3 3 2 2 1 1
|
|
|
80 + 33
|
|
|
P 70 + 3 3 2 2
E |
R |
C |
E 60 + 2 2
N |
T |
|
S 50 + 3 3 22
U |
R |
V |
I 40 + 3 3
V |
A |
L |
30 + 3 3 2 2
|
|
|
20 + 3 3
|
|
|
10 + 3 3
|
|
|
0 + 3
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 10 20 30 40 50 60 70
WEEK
NOTE: 2 obs hidden.
O-NITROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
0.0% 15 SSAC = 1
0.600% 15 SSAC = 2
1.80% 15 SSAC = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
|
|
|
90 + 3 3
|
|
|
80 + 3 3 1 1
|
|
|
P 70 + 3 3
E |
R |
C |
E 60 + 3 3
N |
T |
|
S 50 + 33
U |
R |
V |
I 40 + 3 3
V |
A |
L |
30 + 3 3
|
|
|
20 +
|
|
|
10 +
|
|
|
0 + 3
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 10 20 30 40 50 60 70
WEEK
NOTE: 2 obs hidden.