TDMS Study 05092-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
O-NITROANISOLE
NTP Experiment-Test: 05092-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
Facility: Southern Research Institute
Chemical CAS #: 0091-23-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 10
Early Deaths
Natural Death 5 8 7
Moribund Sacrifice 7 16 10
Survivors
Terminal Sacrifice 38 26 33
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (10) (48) (48)
Cyst 1 (2%)
Dilatation 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Intestine Large, Cecum (50) (10) (48) (50)
Edema 1 (2%)
Intestine Large, Colon (49) (10) (48) (50)
Edema 1 (2%)
Intestine Large, Rectum (50) (10) (50) (50)
Inflammation, Chronic 1 (2%)
Intestine Small, Duodenum (50) (10) (49) (50)
Cyst 1 (10%)
Mucosa, Hyperplasia 1 (2%)
Intestine Small, Ileum (49) (10) (48) (50)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Pyogranulomatous 1 (2%)
Lymphoid Tissue, Hyperplasia 1 (10%)
Intestine Small, Jejunum (50) (10) (49) (49)
Lymphoid Tissue, Hyperplasia 1 (10%)
Liver (50) (10) (50) (10) (50) (10)
Basophilic Focus 3 (6%)
Clear Cell Focus 1 (2%) 4 (8%) 1 (10%)
Cytologic Alterations 1 (2%) 1 (2%)
Eosinophilic Focus 11 (22%) 6 (12%) 1 (10%) 21 (42%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 2 (4%) 4 (8%)
Hemorrhage 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 3 (6%) 13 (26%)
Infarct 1 (2%)
Inflammation, Chronic 4 (8%) 10 (20%) 5 (10%)
Inflammation, Chronic Active 7 (70%) 4 (40%) 4 (40%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mixed Cell Focus 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%)
Hepatocyte, Cytologic Alterations 8 (16%) 1 (10%) 13 (26%) 9 (90%)
Hepatocyte, Vacuolization Cytoplasmic 2 (4%) 1 (2%) 2 (20%)
Kupffer Cell, Hyperplasia 3 (6%) 5 (10%) 1 (2%)
Kupffer Cell, Pigmentation 3 (6%)
Lobules, Necrosis 3 (6%) 8 (16%) 3 (6%)
Periportal, Inflammation 1 (2%)
Mesentery (9) (1) (7) (5)
Accessory Spleen 1 (11%)
Inflammation, Suppurative 1 (14%) 1 (20%)
Fat, Hemorrhage 1 (20%)
Fat, Necrosis 6 (67%) 2 (29%) 1 (20%)
Pancreas (50) (10) (50) (50)
Atrophy 1 (2%) 1 (10%) 3 (6%) 2 (4%)
Cyst 2 (4%) 1 (2%) 1 (2%)
Cytoplasmic Alteration 2 (4%) 3 (6%) 3 (6%)
Focal Cellular Change 1 (2%)
Hyperplasia, Lymphoid 14 (28%) 8 (16%) 13 (26%)
Salivary Glands (49) (10) (50) (50)
Hyperplasia, Lymphoid 18 (37%) 24 (48%) 19 (38%)
Stomach, Forestomach (50) (10) (50) (50) (1)
Cyst 1 (2%) 1 (2%)
Diverticulum 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 2 (4%)
Inflammation, Suppurative 3 (6%) 4 (8%) 3 (6%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 7 (14%) 6 (12%) 7 (14%) 1 (100%)
Stomach, Glandular (50) (10) (50) (50)
Cyst 17 (34%) 2 (20%) 20 (40%) 13 (26%)
Dysplasia 1 (2%) 1 (2%)
Edema 1 (2%) 1 (2%)
Erosion 2 (4%) 4 (8%) 2 (4%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Acute 1 (10%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Subacute 1 (2%)
Mineralization 1 (2%)
Mucosa, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (50)
Epicardium, Inflammation, Chronic 1 (2%)
Epicardium, Inflammation, Suppurative 1 (2%) 1 (2%)
Myocardium, Fibrosis 1 (2%)
Myocardium, Inflammation, Chronic 2 (4%) 3 (6%)
Myocardium, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10) (50) (50)
Accessory Adrenal Cortical Nodule 9 (18%) 7 (14%) 8 (16%)
Basophilic Focus 1 (2%) 2 (4%) 2 (4%)
Clear Cell Focus 1 (2%)
Cyst 3 (6%) 1 (2%) 2 (4%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 5 (10%) 2 (20%) 6 (12%) 6 (12%)
Capsule, Hyperplasia 5 (10%) 2 (4%)
Subcapsular, Hyperplasia 6 (60%)
X-Zone, Degeneration, Fatty 1 (2%)
Adrenal Gland, Medulla (50) (10) (50) (50)
Hyperplasia 3 (6%) 4 (8%)
Islets, Pancreatic (50) (10) (50) (50)
Cyst 1 (10%)
Hyperplasia 10 (20%) 2 (20%) 12 (24%) 7 (14%)
Hyperplasia, Lymphoid 1 (2%)
Parathyroid Gland (50) (9) (48) (49)
Cyst 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (49) (10) (47) (48) (1)
Pars Distalis, Angiectasis 3 (6%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 10 (21%) 5 (10%)
Thyroid Gland (50) (9) (50) (50)
Degeneration, Cystic 23 (46%) 3 (33%) 19 (38%) 25 (50%)
Inflammation, Chronic 2 (4%) 4 (8%) 2 (4%)
Inflammation, Suppurative 3 (6%) 2 (4%)
Follicle, Cyst 3 (6%) 2 (4%)
Follicular Cell, Hyperplasia 9 (18%) 7 (14%) 4 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Bacterium 1 (50%)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2) (2)
Ectasia 2 (100%) 2 (100%)
Inflammation, Chronic 1 (50%) 1 (50%)
Pigmentation 2 (100%) 1 (50%)
Ovary (49) (10) (50) (48)
Angiectasis 12 (24%) 11 (22%) 6 (13%)
Cyst 20 (41%) 17 (34%) 11 (23%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 3 (6%) 2 (4%) 4 (8%)
Mineralization 1 (2%)
Pigmentation 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (10) (50) (6) (50) (8)
Angiectasis 3 (6%) 3 (6%) 2 (4%)
Exudate 8 (16%) 2 (20%) 4 (8%) 2 (33%) 6 (12%) 4 (50%)
Hydrometra 9 (18%) 11 (22%) 6 (12%)
Hyperplasia 1 (10%)
Hyperplasia, Cystic 48 (96%) 9 (90%) 46 (92%) 6 (100%) 48 (96%) 8 (100%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Epithelium, Hyperplasia, Focal 1 (17%)
Mucosa, Metaplasia, Squamous 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (50) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Hypercellularity 3 (6%) 10 (20%) 9 (18%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (50) (10) (50) (1) (50)
Bronchial, Hemorrhage 1 (2%)
Bronchial, Hyperplasia, Lymphoid 1 (100%)
Iliac, Hematopoietic Cell Proliferation 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%) 4 (8%)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 2 (4%)
Mediastinal, Hyperplasia, Plasma Cell 3 (6%) 1 (2%) 4 (8%)
Mediastinal, Inflammation, Suppurative 2 (4%)
Mediastinal, Necrosis 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Pancreatic, Hemorrhage 1 (2%)
Pancreatic, Hyperplasia, Plasma Cell 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%) 4 (8%)
Renal, Inflammation, Suppurative 1 (2%)
Lymph Node, Mandibular (49) (10) (49) (49)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%) 1 (2%)
Hyperplasia, Mast Cell 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (47) (10) (47) (48)
Depletion Cellular 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 4 (9%) 5 (10%)
Hemorrhage 4 (9%) 6 (13%) 9 (19%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%)
Hyperplasia, Plasma Cell 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Spleen (50) (10) (50) (2) (50) (1)
Congestion 2 (4%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 14 (28%) 1 (10%) 25 (50%) 17 (34%)
Pigmentation, Hemosiderin 9 (18%) 4 (8%) 1 (50%) 12 (24%) 1 (100%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 21 (42%) 8 (16%) 1 (50%) 11 (22%)
Red Pulp, Atrophy 1 (2%) 2 (4%)
Red Pulp, Hyperplasia 4 (8%) 1 (2%) 3 (6%)
Thymus (47) (10) (44) (47)
Angiectasis 1 (2%) 2 (5%) 1 (2%)
Cyst 2 (20%) 9 (20%) 2 (4%)
Depletion Cellular 2 (4%) 5 (11%) 5 (11%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10) (50) (50)
Hyperplasia, Cystic 7 (14%) 7 (14%) 7 (14%)
Hyperplasia, Lobular 2 (4%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Skin (50) (10) (50) (2) (50)
Acanthosis 1 (2%) 4 (8%)
Hemorrhage 1 (50%)
Inflammation, Acute 1 (50%)
Inflammation, Chronic 2 (4%)
Ulcer 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50) (50)
Hyperostosis 18 (36%) 12 (24%) 13 (26%)
Femur, Hyperostosis 1 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (10) (50) (50)
Compression 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Cerebrum, Necrosis 1 (2%)
Hippocampus, Necrosis 1 (2%)
Thalamus, Mineralization 39 (80%) 9 (90%) 45 (90%) 44 (88%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (50) (50) (1)
Congestion 3 (6%) 1 (2%)
Edema 1 (10%)
Hemorrhage 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 17 (34%) 19 (38%) 19 (38%)
Infiltration Cellular, Histiocyte 4 (8%) 6 (12%) 4 (8%)
Inflammation, Suppurative 3 (6%) 1 (2%) 1 (2%)
Leukocytosis 1 (2%)
Thrombosis 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%)
Bronchiole, Epithelium, Proliferation 3 (6%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (50) (10) (50) (5) (50) (10)
Exudate 6 (12%) 5 (10%) 27 (54%)
Glands, Dilatation 9 (18%) 1 (10%) 12 (24%) 36 (72%) 9 (90%)
Glands, Hyperplasia 2 (4%) 4 (8%) 34 (68%) 6 (60%)
Mucosa, Degeneration, Hyaline 8 (16%) 7 (70%) 7 (14%) 5 (100%) 12 (24%) 6 (60%)
Mucosa, Hyperplasia 1 (2%)
Olfactory Epithelium, Cyst 2 (4%)
Olfactory Epithelium, Metaplasia 1 (2%) 1 (2%) 20 (40%) 7 (70%)
Trachea (50) (10) (50) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cataract 1 (100%)
Phthisis Bulbi 1 (100%)
Cornea, Hyperplasia 1 (100%)
Cornea, Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (50)
Casts Protein 20 (40%) 2 (20%) 18 (36%) 19 (38%)
Cyst 4 (8%) 2 (4%) 4 (8%)
Glomerulosclerosis 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 22 (44%) 21 (42%) 23 (46%)
Inflammation, Chronic 1 (2%) 6 (60%)
Inflammation, Suppurative 2 (4%)
Metaplasia, Osseous 1 (2%) 1 (2%) 1 (2%)
Mineralization 22 (44%) 1 (10%) 18 (36%) 12 (24%)
Glomerulus, Hyperplasia 1 (2%)
Glomerulus, Necrosis 1 (2%)
Interstitial Tissue, Pigmentation 1 (2%)
Renal Tubule, Atrophy 2 (4%) 1 (2%) 3 (6%)
Renal Tubule, Cytoplasmic Alteration 1 (2%) 2 (4%)
Renal Tubule, Dilatation 5 (10%) 5 (10%) 3 (6%)
Renal Tubule, Necrosis 1 (2%) 3 (6%)
Renal Tubule, Pigmentation 2 (4%) 1 (2%) 1 (2%)
Renal Tubule, Regeneration 33 (66%) 2 (20%) 28 (56%) 17 (34%)
Urinary Bladder (50) (10) (50) (50)
Edema 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 27 (54%) 24 (48%) 25 (50%)
Inflammation, Chronic 4 (40%)
Transitional Epithelium, Degeneration,
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Ballooning 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 5
Survivors
Terminal Sacrifice 45
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (10)
Hyperplasia, Lymphoid 3 (6%)
Intestine Small, Duodenum (49) (10)
Mucosa, Hyperplasia 3 (6%)
Intestine Small, Ileum (49) (10)
Hyperplasia, Lymphoid 1 (2%)
Liver (50) (10)
Cytologic Alterations 1 (2%)
Eosinophilic Focus 16 (32%) 1 (10%)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 6 (12%)
Inflammation, Chronic 13 (26%)
Inflammation, Chronic Active 6 (60%)
Hepatocyte, Cytologic Alterations 40 (80%) 9 (90%)
Kupffer Cell, Pigmentation 3 (6%)
Lobules, Necrosis 2 (4%)
Mesentery (2)
Hyperplasia, Lymphoid 2 (100%)
Fat, Necrosis 1 (50%)
Pancreas (50) (10)
Atrophy 2 (4%)
Cyst 2 (4%)
Hyperplasia, Lymphoid 7 (14%)
Salivary Glands (50) (10)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 20 (40%)
Inflammation, Chronic 1 (10%)
Stomach, Forestomach (50) (10)
Diverticulum 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Mucosa, Hyperplasia 2 (4%)
Stomach, Glandular (50) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst 11 (22%) 1 (10%)
Edema 1 (2%)
Epithelium, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10)
Myocardium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10)
Accessory Adrenal Cortical Nodule 14 (28%) 2 (20%)
Cyst 1 (2%)
Developmental Malformation 3 (6%)
Hyperplasia, Focal 4 (8%)
Capsule, Hyperplasia 2 (4%)
Subcapsular, Hyperplasia 2 (20%)
Adrenal Gland, Medulla (50) (10)
Hyperplasia 1 (2%)
Islets, Pancreatic (50) (10)
Hyperplasia 2 (4%)
Parathyroid Gland (49) (10)
Cyst 2 (4%)
Ectopic Thymus 2 (4%)
Hyperplasia 1 (2%)
Infiltration Cellular, Histiocyte 1 (10%)
Pigmentation 1 (10%)
Pituitary Gland (48) (10)
Pars Distalis, Cyst 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (10)
Degeneration, Cystic 28 (56%) 1 (10%)
Inflammation, Chronic 5 (10%)
Follicular Cell, Hyperplasia 1 (2%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (10)
Angiectasis 12 (24%) 1 (10%)
Cyst 10 (20%)
Hemorrhage 2 (4%)
Metaplasia, Osseous 1 (2%)
Thrombosis 1 (2%)
Corpus Luteum, Hyperplasia 1 (2%)
Granulosa Cell, Hyperplasia 1 (2%)
Thecal Cell, Hyperplasia 1 (2%)
Uterus (50) (10)
Angiectasis 1 (2%)
Exudate 2 (4%) 3 (30%)
Hydrometra 15 (30%)
Hyperplasia, Cystic 47 (94%) 5 (50%)
Mucosa, Dysplasia 2 (4%)
Mucosa, Metaplasia, Squamous 4 (8%)
Myometrium, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10)
Hypercellularity 2 (4%)
Myelofibrosis 1 (2%)
Lymph Node, Mesenteric (48) (10)
Hemorrhage 5 (10%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (50) (10)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 4 (8%)
Pigmentation, Hemosiderin 1 (2%)
Lymphoid Follicle, Hyperplasia 5 (10%)
Thymus (49) (10)
Cyst 3 (6%) 2 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10)
Hyperplasia, Cystic 2 (4%)
Hyperplasia, Lobular 6 (12%)
Skin (50) (10)
Acanthosis 1 (2%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10)
Hyperostosis 11 (22%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10)
Cyst 2 (4%)
Thalamus, Mineralization 43 (86%) 7 (70%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10)
Hemorrhage 3 (6%)
Hyperplasia, Lymphoid 20 (40%)
Inflammation, Chronic 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Bronchiole, Epithelium, Proliferation 4 (8%)
Mediastinum, Ectopic Tissue 1 (10%)
Nose (50) (10)
Exudate 49 (98%) 3 (30%)
Glands, Dilatation 49 (98%) 10 (100%)
Glands, Hyperplasia 50 (100%) 10 (100%)
Mucosa, Degeneration, Hyaline 45 (90%) 10 (100%)
Olfactory Epithelium, Cyst 6 (12%)
Olfactory Epithelium, Metaplasia 49 (98%) 10 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10)
Casts Protein 30 (60%) 4 (40%)
Fibrosis 1 (2%)
Hyperplasia, Lymphoid 14 (28%)
Inflammation, Chronic 4 (40%)
Metaplasia, Osseous 6 (12%)
Mineralization 9 (18%) 3 (30%)
Renal Tubule, Regeneration 12 (24%) 1 (10%)
Urinary Bladder (50) (10)
Edema 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hyperplasia, Lymphoid 23 (46%)
Inflammation, Chronic 1 (10%)
Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 9
Early Deaths
Moribund Sacrifice 14 5 8
Natural Death 1 2 3
Survivors
Terminal Sacrifice 35 43 39
Other 1
Animals Examined Microscopically 50 10 50 10 50 9
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (9) (45) (47)
Dilatation 1 (2%) 1 (2%)
Intestine Large, Cecum (49) (10) (49) (49)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Duodenum (50) (10) (48) (49)
Inflammation, Chronic 1 (2%)
Metaplasia, Squamous 1 (2%)
Intestine Small, Ileum (49) (10) (48) (47)
Hyperplasia, Lymphoid 1 (2%)
Liver (50) (10) (50) (10) (50) (9)
Angiectasis 1 (2%)
Basophilic Focus 3 (6%) 1 (10%) 1 (2%) 1 (2%)
Clear Cell Focus 9 (18%) 7 (14%) 1 (10%) 9 (18%)
Eosinophilic Focus 1 (2%) 15 (30%) 16 (32%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 4 (8%) 20 (40%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 2 (20%) 5 (56%)
Mixed Cell Focus 1 (2%) 3 (6%)
Regeneration, Focal 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Cytologic Alterations 44 (88%) 7 (70%) 49 (98%) 9 (100%)
Hepatocyte, Cytomegaly 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 6 (12%) 4 (40%) 7 (14%) 2 (20%) 3 (33%)
Kupffer Cell, Hyperplasia 2 (4%)
Kupffer Cell, Pigmentation 3 (6%)
Lobules, Necrosis 3 (6%) 13 (26%) 27 (54%) 2 (22%)
Oval Cell, Hyperplasia 1 (2%)
Mesentery (4) (2) (2) (4)
Hemorrhage 1 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Pyogranulomatous 1 (50%)
Fat, Inflammation, Chronic 1 (50%)
Fat, Necrosis 2 (50%) 1 (50%) 1 (50%) 1 (25%)
Pancreas (50) (10) (49) (49)
Atrophy 1 (2%)
Focal Cellular Change 1 (2%)
Hyperplasia, Focal 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 3 (6%)
Inflammation, Chronic 1 (10%)
Duct, Hyperplasia 1 (2%)
Salivary Glands (50) (10) (50) (50)
Hyperplasia, Lymphoid 16 (32%) 21 (42%) 20 (40%)
Inflammation, Chronic 1 (2%) 1 (10%)
Stomach, Forestomach (50) (10) (50) (50)
Cyst 2 (4%)
Diverticulum 4 (8%) 1 (2%) 1 (2%)
Erosion 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 2 (4%)
Mucosa, Hyperplasia 6 (12%) 2 (4%)
Stomach, Glandular (50) (10) (50) (49)
Cyst 7 (14%) 1 (10%) 15 (30%) 11 (22%)
Dysplasia 1 (2%) 1 (2%)
Erosion 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Tooth (11) (20) (12)
Dysplasia 10 (91%) 18 (90%) 12 (100%)
Inflammation, Suppurative 1 (9%) 2 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (50)
Thrombosis 1 (2%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Myocardium, Degeneration 2 (4%)
Myocardium, Inflammation, Chronic 2 (4%) 1 (10%) 2 (4%) 1 (2%)
Myocardium, Mineralization 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10) (50) (50)
Accessory Adrenal Cortical Nodule 8 (16%) 1 (2%) 5 (10%)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%) 3 (6%) 6 (12%)
Developmental Malformation 2 (4%)
Hyperplasia, Focal 24 (48%) 21 (42%) 23 (46%)
Hypertrophy, Focal 1 (10%)
Capsule, Hyperplasia 6 (12%) 6 (12%) 5 (10%)
Subcapsular, Hyperplasia 4 (40%)
Adrenal Gland, Medulla (50) (10) (49) (50)
Hyperplasia 1 (2%)
Islets, Pancreatic (50) (10) (49) (49)
Hyperplasia 21 (42%) 3 (30%) 20 (41%) 9 (18%)
Parathyroid Gland (50) (10) (49) (50)
Cyst 2 (4%) 2 (20%) 3 (6%) 2 (4%)
Hyperplasia 1 (2%)
Pigmentation 1 (2%)
Pituitary Gland (47) (8) (46) (49)
Pars Distalis, Cyst 1 (2%) 4 (9%) 7 (14%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (49) (10) (49) (50)
Degeneration, Cystic 12 (24%) 1 (10%) 11 (22%) 9 (18%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Follicle, Dilatation 1 (10%)
Follicular Cell, Hyperplasia 3 (6%) 6 (12%) 6 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (4) (1)
Dilatation 2 (50%)
Epididymis (50) (10) (50) (50)
Atypia Cellular 1 (2%)
Fibrosis 3 (6%)
Granuloma Sperm 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%) 5 (10%)
Preputial Gland (24) (3) (24) (1) (25) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Atrophy 2 (67%) 1 (100%) 1 (50%)
Ectasia 18 (75%) 3 (100%) 20 (83%) 1 (100%) 24 (96%) 2 (100%)
Fibrosis 1 (4%)
Inflammation, Chronic 13 (54%) 2 (67%) 7 (29%) 13 (52%) 1 (50%)
Inflammation, Suppurative 6 (25%) 4 (17%) 4 (16%)
Prostate (50) (10) (50) (50)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (50) (10) (50) (50)
Dilatation 6 (12%) 3 (6%) 1 (2%)
Testes (50) (10) (50) (50)
Granuloma Sperm 1 (2%)
Hypospermia 2 (4%) 1 (2%)
Mineralization 1 (2%) 2 (4%)
Interstitial Cell, Hyperplasia 2 (4%)
Seminiferous Tubule, Atrophy 3 (6%) 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (50) (50)
Angiectasis 2 (4%)
Hypercellularity 1 (2%) 10 (20%) 6 (12%)
Lymph Node (50) (10) (50) (1) (50) (1)
Inguinal, Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Inguinal, Pigmentation 1 (2%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Inflammation, Suppurative 1 (2%)
Mediastinal, Inflammation, Pyogranulomatous 1 (2%)
Pancreatic, Hemorrhage 1 (2%) 1 (2%)
Lymph Node, Mandibular (48) (10) (49) (49)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (10%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node, Mesenteric (47) (10) (49) (1) (46) (1)
Hematopoietic Cell Proliferation 4 (9%) 16 (33%) 6 (13%)
Hemorrhage 19 (40%) 1 (10%) 23 (47%) 21 (46%) 1 (100%)
Hyperplasia, Histiocytic 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 4 (9%) 4 (8%) 4 (9%)
Hyperplasia, Reticulum Cell 1 (2%)
Infiltration Cellular, Mast Cell 2 (4%) 1 (2%)
Spleen (50) (10) (50) (49)
Congestion 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 10 (20%) 12 (24%) 10 (20%)
Pigmentation, Hemosiderin 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%)
Lymphoid Follicle, Hyperplasia 3 (6%) 7 (14%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Red Pulp, Atrophy 1 (2%) 1 (2%)
Red Pulp, Hyperplasia 2 (4%)
Thymus (47) (10) (47) (45)
Cyst 8 (17%) 3 (30%) 7 (15%) 6 (13%)
Depletion Cellular 1 (2%) 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (10) (50) (50) (1)
Acanthosis 4 (8%) 1 (2%) 4 (8%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%)
Inflammation, Suppurative 2 (4%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50) (50)
Hyperostosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50) (50)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
Thalamus, Mineralization 41 (82%) 8 (80%) 43 (86%) 44 (88%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (50) (4) (50)
Congestion 1 (2%)
Hemorrhage 2 (4%) 1 (10%) 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 5 (10%) 6 (12%)
Infiltration Cellular, Histiocyte 5 (10%) 5 (10%) 1 (25%) 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Inflammation, Suppurative 3 (6%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 4 (8%) 2 (4%)
Bronchiole, Epithelium, Proliferation 2 (4%) 13 (26%)
Nose (50) (10) (50) (50) (2)
Exudate 4 (8%) 4 (8%) 6 (12%)
Glands, Dilatation 3 (6%) 2 (20%) 6 (12%) 12 (24%) 2 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Glands, Hyperplasia 1 (2%) 2 (4%) 12 (24%)
Olfactory Epithelium, Metaplasia 7 (14%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3)
Cataract 1 (33%)
Cornea, Hyperplasia 2 (67%)
Cornea, Inflammation, Chronic Active 2 (67%)
Cornea, Mineralization 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (50)
Casts Protein 12 (24%) 14 (28%) 18 (36%)
Cyst 27 (54%) 1 (10%) 30 (60%) 16 (32%)
Fibrosis 1 (2%)
Glomerulosclerosis 2 (4%) 1 (2%) 1 (2%)
Hydronephrosis 6 (12%)
Hyperplasia, Lymphoid 20 (40%) 16 (32%) 25 (50%)
Inflammation, Chronic 1 (2%) 2 (20%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 2 (4%) 3 (6%)
Mineralization 41 (82%) 4 (40%) 48 (96%) 50 (100%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Cytoplasmic Alteration 1 (2%)
Renal Tubule, Dilatation 3 (6%)
Renal Tubule, Hyperplasia 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 5 (10%)
Renal Tubule, Regeneration 48 (96%) 10 (100%) 46 (92%) 48 (96%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (50) (10) (50) (49)
Dilatation 3 (6%) 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 4 (8%) 5 (10%)
Inflammation, Chronic 1 (10%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 7
Natural Death 3
Survivors
Terminal Sacrifice 40
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (10)
Edema 1 (2%)
Intestine Small, Duodenum (50) (9)
Mucosa, Hyperplasia 3 (6%)
Intestine Small, Ileum (49) (10)
Hyperplasia, Lymphoid 2 (4%)
Liver (50) (10)
Angiectasis 1 (2%)
Clear Cell Focus 2 (4%)
Eosinophilic Focus 13 (26%) 1 (10%)
Hemorrhage 28 (56%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 3 (30%)
Hepatocyte, Cytologic Alterations 49 (98%) 10 (100%)
Kupffer Cell, Pigmentation 16 (32%)
Lobules, Necrosis 34 (68%) 4 (40%)
Oval Cell, Hyperplasia 1 (2%)
Pancreas (50) (10)
Atrophy 1 (10%)
Hyperplasia, Lymphoid 5 (10%)
Infiltration Cellular, Histiocyte 1 (2%)
Acinar Cell, Vacuolization Cytoplasmic 1 (2%)
Salivary Glands (50) (10)
Hyperplasia, Lymphoid 10 (20%)
Acinar Cell, Vacuolization Cytoplasmic 1 (2%)
Stomach, Forestomach (50) (10)
Cyst 1 (2%)
Diverticulum 1 (2%)
Erosion 1 (2%)
Mucosa, Hyperplasia 4 (8%)
Stomach, Glandular (50) (10)
Cyst 8 (16%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Erosion 1 (2%)
Inflammation, Chronic 1 (2%)
Tooth (3)
Dysplasia 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10)
Myocardium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (10)
Accessory Adrenal Cortical Nodule 9 (19%) 1 (10%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 21 (44%)
Hypertrophy, Focal 1 (10%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Capsule, Hyperplasia 4 (8%)
Subcapsular, Hyperplasia 1 (10%)
Adrenal Gland, Medulla (48) (10)
Hyperplasia 2 (4%)
Islets, Pancreatic (50) (10)
Hyperplasia 2 (4%)
Parathyroid Gland (48) (10)
Cyst 3 (6%) 1 (10%)
Infiltration Cellular, Histiocyte 1 (2%)
Pituitary Gland (48) (9)
Pars Distalis, Cyst 1 (2%)
Pars Intermedia, Cytoplasmic Alteration 1 (2%)
Thyroid Gland (50) (10)
Degeneration, Cystic 6 (12%) 1 (10%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (10)
Atypia Cellular 1 (2%)
Thrombosis 1 (2%)
Preputial Gland (10)
Ectasia 10 (100%)
Inflammation, Chronic 4 (40%)
Inflammation, Suppurative 1 (10%)
Testes (50) (10)
Hypospermia 1 (2%)
Mineralization 2 (4%)
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10)
Angiectasis 1 (2%)
Hypercellularity 7 (14%)
Lymph Node (50) (10)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (50) (10)
Hematopoietic Cell Proliferation 3 (6%)
Hemorrhage 14 (28%)
Hyperplasia, Lymphoid 7 (14%)
Spleen (48) (10)
Angiectasis 3 (6%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 7 (15%)
Lymphoid Follicle, Atrophy 1 (2%)
Lymphoid Follicle, Hyperplasia 2 (4%)
Red Pulp, Atrophy 1 (2%)
Thymus (48) (10)
Cyst 6 (13%) 1 (10%)
Depletion Cellular 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (10)
Acanthosis 1 (2%)
Hair Follicle, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10)
Pigmentation 2 (4%)
Thalamus, Mineralization 40 (80%) 6 (60%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10)
Congestion 1 (2%)
Hemorrhage 6 (12%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Megakaryocyte 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%)
Bronchiole, Epithelium, Proliferation 14 (28%)
Nose (50) (10)
Exudate 49 (98%) 1 (10%)
Glands, Dilatation 49 (98%) 10 (100%)
Glands, Hyperplasia 49 (98%) 10 (100%)
Olfactory Epithelium, Cyst 18 (36%)
Olfactory Epithelium, Metaplasia 46 (92%) 10 (100%)
Olfactory Epithelium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10)
Casts Protein 5 (10%)
Cyst 4 (8%) 1 (10%)
Fibrosis 1 (2%)
Hyperplasia, Lymphoid 8 (16%)
Inflammation, Chronic 1 (10%)
Mineralization 36 (72%) 2 (20%)
Renal Tubule, Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 24
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Regeneration 32 (64%) 5 (50%)
Urinary Bladder (50) (10)
Hyperplasia, Lymphoid 5 (10%)
Inflammation, Chronic 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 25
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---------- END OF REPORT ----------
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