INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
O-NITROANISOLE
NTP Experiment-Test: 05092-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
Facility: Southern Research Institute
Chemical CAS #: 0091-23-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 10
Early Deaths
Natural Death 5 8 7
Moribund Sacrifice 7 16 10
Survivors
Terminal Sacrifice 38 26 33
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (10) (50) (50)
Gallbladder (48) (10) (48) (48)
Intestine Large, Cecum (50) (10) (48) (50)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Large, Colon (49) (10) (48) (50)
Intestine Large, Rectum (50) (10) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Intestine Small, Duodenum (50) (10) (49) (50)
Carcinoma 1 (2%)
Fibrous Histiocytoma 1 (10%)
Intestine Small, Ileum (49) (10) (48) (50)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Jejunum (50) (10) (49) (49)
Carcinoma 2 (4%)
Liver (50) (10) (50) (10) (50) (10)
Hemangiosarcoma 1 (2%) 1 (2%)
Hepatoblastoma 1 (2%) 1 (2%) 1 (2%)
Hepatoblastoma, Multiple 1 (2%)
Hepatocellular Carcinoma 4 (8%) 1 (2%) 7 (14%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 12 (24%) 11 (22%) 1 (10%) 11 (22%) 1 (10%)
Hepatocellular Adenoma, Multiple 2 (4%) 9 (18%) 25 (50%) 1 (10%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Mesentery (9) (1) (7) (5)
Fibrous Histiocytoma 1 (100%)
Hemangioma 1 (14%)
Histiocytic Sarcoma 1 (11%)
Pancreas (50) (10) (50) (50)
Fibrous Histiocytoma 1 (10%)
Page 2
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Histiocytic Sarcoma 1 (2%)
Salivary Glands (49) (10) (50) (50)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (50) (10) (50) (50) (1)
Squamous Cell Papilloma 3 (6%) 1 (2%) 6 (12%)
Stomach, Glandular (50) (10) (50) (50)
Carcinoma 1 (2%)
Fibrous Histiocytoma 1 (10%)
Tongue (1)
Tooth (2)
Fibrosarcoma 1 (50%)
Squamous Cell Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (50)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10) (50) (50)
Capsule, Carcinoma 1 (2%)
Adrenal Gland, Medulla (50) (10) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (10) (50) (50)
Adenoma 2 (4%) 1 (2%)
Pituitary Gland (49) (10) (47) (48) (1)
Pars Distalis, Adenoma 7 (14%) 1 (10%) 6 (13%) 8 (17%)
Pars Distalis, Carcinoma 1 (100%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 3 (6%)
Thyroid Gland (50) (9) (50) (50)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (10) (50) (48)
Adenoma 1 (2%) 1 (10%) 1 (2%)
Cystadenoma 1 (2%)
Fibrous Histiocytoma 1 (10%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
Luteoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Uterus (50) (10) (50) (6) (50) (8)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Fibrous Histiocytoma 1 (10%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (2%) 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Polyp Stromal 3 (6%) 5 (10%) 4 (8%)
Sarcoma Stromal 1 (2%) 1 (17%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (50) (50)
Hemangiosarcoma 1 (2%)
Lymph Node (50) (10) (50) (1) (50)
Axillary, Histiocytic Sarcoma 1 (2%)
Bronchial, Histiocytic Sarcoma 1 (2%)
Bronchial, Osteosarcoma, Metastatic, Bone 1 (2%)
Iliac, Fibrous Histiocytoma 1 (10%)
Iliac, Histiocytic Sarcoma 1 (2%)
Inguinal, Fibrosarcoma, Metastatic, Skin 1 (2%)
Inguinal, Histiocytic Sarcoma 1 (2%)
Lumbar, Histiocytic Sarcoma 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Hepatoblastoma, Metastatic,
Liver 1 (2%)
Mediastinal, Histiocytic Sarcoma 2 (4%) 1 (2%)
Mediastinal, Osteosarcoma, Metastatic, Bone 1 (2%)
Renal, Fibrous Histiocytoma 1 (10%)
Renal, Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node, Mandibular (49) (10) (49) (49)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Squamous Cell Carcinoma, Metastatic, Tooth 1 (2%)
Lymph Node, Mesenteric (47) (10) (47) (48)
Fibrous Histiocytoma 1 (10%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Page 4
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (50) (10) (50) (2) (50) (1)
Fibrous Histiocytoma 1 (10%)
Hemangioma 1 (2%)
Hemangiosarcoma 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Thymus (47) (10) (44) (47)
Fibrous Histiocytoma 1 (10%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10) (50) (50)
Carcinoma 1 (2%)
Skin (50) (10) (50) (2) (50)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50) (50)
Osteosarcoma 2 (4%) 1 (2%) 1 (2%)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (10) (50) (50)
Cranial Nerve, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (50) (50) (1)
Alveolar/Bronchiolar Adenoma 4 (8%) 1 (10%) 2 (4%) 2 (4%) 1 (100%)
Alveolar/Bronchiolar Adenoma, Multiple, Two 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma 1 (10%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 2 (4%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%) 1 (2%)
Page 5
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Squamous Cell Carcinoma, Metastatic, Tooth 1 (2%)
Nose (50) (10) (50) (5) (50) (10)
Mucosa, Adenoma 1 (2%)
Trachea (50) (10) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (3) (3)
Adenoma 3 (100%) 3 (100%)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma 1 (10%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (10) (50) (50)
Fibrous Histiocytoma 1 (10%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10) *(50) *(10) *(50) *(10)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 6 (12%) 3 (6%)
Lymphoma Malignant Mixed 3 (6%) 6 (12%) 10 (20%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 39 4 44 2 47 4
Total Primary Neoplasms 67 17 78 2 94 4
Total Animals with Benign Neoplasms 31 3 31 1 43 3
Total Benign Neoplasms 42 3 43 1 66 3
Total Animals with Malignant Neoplasms 20 1 27 1 24 1
Total Malignant Neoplasms 25 14 35 1 28 1
Total Animals with Metastatic Neoplasms 3 7 1
Total Metastatic Neoplasm 6 16 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 5
Survivors
Terminal Sacrifice 45
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (49) (10)
Intestine Small, Jejunum (50) (10)
Liver (50) (10)
Hepatocellular Carcinoma 3 (6%)
Hepatocellular Adenoma 11 (22%)
Hepatocellular Adenoma, Multiple 7 (14%)
Stomach, Forestomach (50) (10)
Squamous Cell Papilloma 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (10)
Adenoma 1 (2%)
Cystadenocarcinoma 1 (2%)
Uterus (50) (10)
Carcinoma 1 (2%)
Page 8
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Hemangioma 1 (2%)
Polyp Stromal 2 (4%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (10)
Lymph Node, Mandibular (49) (10)
Lymph Node, Mesenteric (48) (10)
Spleen (50) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (10)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 9
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 28
Total Primary Neoplasms 37
Total Animals with Benign Neoplasms 22
Total Benign Neoplasms 25
Total Animals with Malignant Neoplasms 10
Total Malignant Neoplasms 12
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 9
Early Deaths
Moribund Sacrifice 14 5 8
Natural Death 1 2 3
Survivors
Terminal Sacrifice 35 43 39
Other 1
Animals Examined Microscopically 50 10 50 10 50 9
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (10) (49) (49)
Intestine Small, Duodenum (50) (10) (48) (49)
Carcinoma 1 (2%)
Intestine Small, Ileum (49) (10) (48) (47)
Carcinoma 1 (2%)
Intestine Small, Jejunum (50) (10) (48) (47) (1)
Carcinoma 1 (2%)
Liver (50) (10) (50) (10) (50) (9)
Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatoblastoma 2 (4%) 14 (28%)
Hepatoblastoma, Multiple 1 (2%) 3 (6%)
Hepatocellular Carcinoma 5 (10%) 11 (22%) 1 (10%) 10 (20%)
Hepatocellular Carcinoma, Multiple 2 (4%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 10 (20%) 2 (20%) 16 (32%) 15 (30%)
Hepatocellular Adenoma, Multiple 4 (8%) 10 (20%) 26 (52%)
Histiocytic Sarcoma 1 (2%)
Mesentery (4) (2) (2) (4)
Hemangioma 1 (25%)
Hepatoblastoma, Metastatic, Liver 2 (50%)
Pancreas (50) (10) (49) (49)
Stomach, Forestomach (50) (10) (50) (50)
Squamous Cell Papilloma 3 (6%) 2 (4%)
Stomach, Glandular (50) (10) (50) (49)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (50)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10) (50) (50)
Adenoma 5 (10%) 3 (6%) 2 (4%)
Capsule, Adenoma 2 (4%) 3 (6%)
Adrenal Gland, Medulla (50) (10) (49) (50)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (10) (49) (49)
Adenoma 2 (4%) 1 (2%)
Pituitary Gland (47) (8) (46) (49)
Pars Distalis, Adenoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (10) (49) (50)
Follicular Cell, Adenoma 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (10) (50) (50)
Penis (1)
Fibrous Histiocytoma 1 (100%)
Prostate (50) (10) (50) (50)
Seminal Vesicle (50) (10) (50) (50)
Testes (50) (10) (50) (50)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (50) (50)
Hemangiosarcoma 2 (4%)
Lymph Node (50) (10) (50) (1) (50) (1)
Lymph Node, Mandibular (48) (10) (49) (49)
Lymph Node, Mesenteric (47) (10) (49) (1) (46) (1)
Spleen (50) (10) (50) (49)
Hemangiosarcoma 1 (2%)
Page 13
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (47) (10) (47) (45)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (10) (50) (50) (1)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Hepatoblastoma, Metastatic, Liver 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (50) (4) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 9 (18%) 3 (75%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple, Two 1 (2%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple, Three 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) 1 (25%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (10) (4) (2)
Adenoma 8 (80%) 4 (100%) 2 (100%)
Adenoma, Multiple, Two 1 (10%)
Carcinoma 1 (10%)
____________________________________________________________________________________________________________________________________
Page 14
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (50)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (50) (10) (50) (49)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10) *(50) *(10) *(50) *(9)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 2 (4%) 6 (12%) 3 (6%) 1 (11%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 15
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 38 2 41 4 49 1
Total Primary Neoplasms 66 2 81 5 88 1
Total Animals with Benign Neoplasms 29 2 37 3 45
Total Benign Neoplasms 47 2 52 3 53
Total Animals with Malignant Neoplasms 16 23 2 27 1
Total Malignant Neoplasms 19 29 2 35 1
Total Animals with Metastatic Neoplasms 3 2
Total Metastatic Neoplasm 3 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 16
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 7
Natural Death 3
Survivors
Terminal Sacrifice 40
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (49) (10)
Intestine Small, Jejunum (50) (10)
Carcinoma 1 (2%)
Liver (50) (10)
Hepatoblastoma 8 (16%)
Hepatoblastoma, Multiple 1 (2%)
Hepatocellular Carcinoma 6 (12%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 16 (32%)
Hepatocellular Adenoma, Multiple 13 (26%) 1 (10%)
Pancreas (50) (10)
Stomach, Forestomach (50) (10)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Medulla (48) (10)
Pheochromocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 17
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Seminal Vesicle (50) (10)
Testes (50) (10)
Hemangiosarcoma 1 (2%) 1 (10%)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10)
Lymph Node (50) (10)
Lymph Node, Mesenteric (50) (10)
Histiocytic Sarcoma 1 (2%)
Spleen (48) (10)
Thymus (48) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (10)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10)
Alveolar/Bronchiolar Adenoma 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
____________________________________________________________________________________________________________________________________
Page 18
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (1)
Adenoma 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 2 (4%)
Lymphoma Malignant Undifferentiated Cell 5 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 19
NTP Experiment-Test: 05092-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 19:16:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.600% 0.600%
15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 41 2
Total Primary Neoplasms 67 2
Total Animals with Benign Neoplasms 31 1
Total Benign Neoplasms 37 1
Total Animals with Malignant Neoplasms 26 1
Total Malignant Neoplasms 30 1
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 20
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