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https://ntp.niehs.nih.gov/go/985

TDMS Study 05092-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           O-NITROANISOLE


NTP Experiment-Test: 05092-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: DOSED FEED                                                                                                 Time: 19:16:20




       Facility:  Southern Research Institute

       Chemical CAS #:  0091-23-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           50           10           50           10           
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
    Natural Death                                      5                         8                         7                        
    Moribund Sacrifice                                 7                        16                        10                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                38                        26                        33                        
  Animals Examined Microscopically                    50           10           50           10           50           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (10)         (50)                      (50)                      
   Gallbladder                                        (48)         (10)         (48)                      (48)                      
   Intestine Large, Cecum                             (50)         (10)         (48)                      (50)                      
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Large, Colon                             (49)         (10)         (48)                      (50)                      
   Intestine Large, Rectum                            (50)         (10)         (50)                      (50)                      
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (10)         (49)                      (50)                      
      Carcinoma                                        1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (10%)                                                         
   Intestine Small, Ileum                             (49)         (10)         (48)                      (50)                      
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (10)         (49)                      (49)                      
      Carcinoma                                        2 (4%)                                                                       
   Liver                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Hepatoblastoma                                   1 (2%)                    1 (2%)                    1 (2%)                   
      Hepatoblastoma, Multiple                                                                             1 (2%)                   
      Hepatocellular Carcinoma                         4 (8%)                    1 (2%)                    7 (14%)                  
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)                    1 (2%)                   
      Hepatocellular Adenoma                          12 (24%)                  11 (22%)      1 (10%)     11 (22%)      1 (10%)     
      Hepatocellular Adenoma, Multiple                 2 (4%)                    9 (18%)                  25 (50%)      1 (10%)     
      Histiocytic Sarcoma                              2 (4%)                                              1 (2%)                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                    1 (2%)                   
   Mesentery                                          (9)          (1)          (7)                       (5)                       
      Fibrous Histiocytoma                                          1 (100%)                                                        
      Hemangioma                                                                 1 (14%)                                            
      Histiocytic Sarcoma                              1 (11%)                                                                      
   Pancreas                                           (50)         (10)         (50)                      (50)                      
      Fibrous Histiocytoma                                          1 (10%)                                                         
                                                             Page   2                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Salivary Glands                                    (49)         (10)         (50)                      (50)                      
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (10)         (50)                      (50)         (1)          
      Squamous Cell Papilloma                          3 (6%)                    1 (2%)                    6 (12%)                  
   Stomach, Glandular                                 (50)         (10)         (50)                      (50)                      
      Carcinoma                                        1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (10%)                                                         
   Tongue                                                                       (1)                                                 
   Tooth                                                                        (2)                                                 
      Fibrosarcoma                                                               1 (50%)                                            
      Squamous Cell Carcinoma                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                      (50)                      
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (50)                      (50)                      
      Capsule, Carcinoma                               1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (10)         (50)                      (50)                      
      Pheochromocytoma Malignant                                                                           1 (2%)                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (10)         (50)                      (50)                      
      Adenoma                                          2 (4%)                                              1 (2%)                   
   Pituitary Gland                                    (49)         (10)         (47)                      (48)         (1)          
      Pars Distalis, Adenoma                           7 (14%)      1 (10%)      6 (13%)                   8 (17%)                  
      Pars Distalis, Carcinoma                                                                                          1 (100%)    
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                    3 (6%)                   
   Thyroid Gland                                      (50)         (9)          (50)                      (50)                      
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                             (2)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (10)         (50)                      (48)                      
      Adenoma                                          1 (2%)       1 (10%)      1 (2%)                                             
      Cystadenoma                                      1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (10%)                                                         
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa-Theca Tumor Benign                                                                         1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Luteoma                                                                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Uterus                                             (50)         (10)         (50)         (6)          (50)         (8)          
      Carcinoma                                        1 (2%)                    1 (2%)                    1 (2%)                   
      Fibrous Histiocytoma                                          1 (10%)                                                         
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyoma                                        1 (2%)                    1 (2%)                    1 (2%)                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Polyp Stromal                                    3 (6%)                    5 (10%)                   4 (8%)                   
      Sarcoma Stromal                                                            1 (2%)       1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (50)                      (50)                      
      Hemangiosarcoma                                                            1 (2%)                                             
   Lymph Node                                         (50)         (10)         (50)         (1)          (50)                      
      Axillary, Histiocytic Sarcoma                    1 (2%)                                                                       
      Bronchial, Histiocytic Sarcoma                   1 (2%)                                                                       
      Bronchial, Osteosarcoma, Metastatic, Bone                                  1 (2%)                                             
      Iliac, Fibrous Histiocytoma                                   1 (10%)                                                         
      Iliac, Histiocytic Sarcoma                       1 (2%)                                                                       
      Inguinal, Fibrosarcoma, Metastatic, Skin                                   1 (2%)                                             
      Inguinal, Histiocytic Sarcoma                    1 (2%)                                                                       
      Lumbar, Histiocytic Sarcoma                      1 (2%)                                                                       
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                                                       
      Mediastinal, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                                                 1 (2%)                                             
      Mediastinal, Histiocytic Sarcoma                 2 (4%)                                              1 (2%)                   
      Mediastinal, Osteosarcoma, Metastatic, Bone                                1 (2%)                                             
      Renal, Fibrous Histiocytoma                                   1 (10%)                                                         
      Renal, Histiocytic Sarcoma                       1 (2%)                                              1 (2%)                   
   Lymph Node, Mandibular                             (49)         (10)         (49)                      (49)                      
      Histiocytic Sarcoma                              2 (4%)                                              1 (2%)                   
      Squamous Cell Carcinoma, Metastatic, Tooth                                 1 (2%)                                             
   Lymph Node, Mesenteric                             (47)         (10)         (47)                      (48)                      
      Fibrous Histiocytoma                                          1 (10%)                                                         
      Histiocytic Sarcoma                              2 (4%)                                              1 (2%)                   
                                                             Page   4                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (10)         (50)         (2)          (50)         (1)          
      Fibrous Histiocytoma                                          1 (10%)                                                         
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                            2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)                                              1 (2%)                   
   Thymus                                             (47)         (10)         (44)                      (47)                      
      Fibrous Histiocytoma                                          1 (10%)                                                         
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)         (50)                      (50)                      
      Carcinoma                                                                  1 (2%)                                             
   Skin                                               (50)         (10)         (50)         (2)          (50)                      
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                      (50)                      
      Osteosarcoma                                     2 (4%)                    1 (2%)                    1 (2%)                   
   Skeletal Muscle                                                              (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (10)         (50)                      (50)                      
      Cranial Nerve, Schwannoma Malignant                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (50)                      (50)         (1)          
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (10%)      2 (4%)                    2 (4%)       1 (100%)    
      Alveolar/Bronchiolar Adenoma, Multiple, Two                                                          1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Fibrous Histiocytoma                                          1 (10%)                                                         
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    2 (4%)                                             
      Histiocytic Sarcoma                              2 (4%)                                              1 (2%)                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                    1 (2%)                    1 (2%)                   
                                                             Page   5                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Squamous Cell Carcinoma, Metastatic, Tooth                                 1 (2%)                                             
   Nose                                               (50)         (10)         (50)         (5)          (50)         (10)         
      Mucosa, Adenoma                                  1 (2%)                                                                       
   Trachea                                            (50)         (10)         (50)                      (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                       (3)                       (3)                       
      Adenoma                                                                    3 (100%)                  3 (100%)                 
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (50)                      (50)                      
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Fibrous Histiocytoma                                          1 (10%)                                                         
      Osteosarcoma, Metastatic, Bone                   1 (2%)                    1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (50)         (10)         (50)                      (50)                      
      Fibrous Histiocytoma                                          1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(50)        *(10)        *(50)        *(10)         
      Histiocytic Sarcoma                              2 (4%)                                              1 (2%)                   
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   2 (4%)                    6 (12%)                   3 (6%)                   
      Lymphoma Malignant Mixed                         3 (6%)                    6 (12%)                  10 (20%)                  
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39           4          44           2          47           4               
     Total Primary Neoplasms                           67          17          78           2          94           4               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31           3          31           1          43           3               
     Total Benign Neoplasms                            42           3          43           1          66           3               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20           1          27           1          24           1               
     Total Malignant Neoplasms                         25          14          35           1          28           1               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       7                       1                           
     Total Metastatic Neoplasm                          6                      16                       2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10                                                               
  Scheduled Sacrifice                                              10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                45                                                                            
  Animals Examined Microscopically                    50           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (49)         (10)                                                             
   Intestine Small, Jejunum                           (50)         (10)                                                             
   Liver                                              (50)         (10)                                                             
      Hepatocellular Carcinoma                         3 (6%)                                                                       
      Hepatocellular Adenoma                          11 (22%)                                                                      
      Hepatocellular Adenoma, Multiple                 7 (14%)                                                                      
   Stomach, Forestomach                               (50)         (10)                                                             
      Squamous Cell Papilloma                          2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (10)                                                             
      Adenoma                                          1 (2%)                                                                       
      Cystadenocarcinoma                               1 (2%)                                                                       
   Uterus                                             (50)         (10)                                                             
      Carcinoma                                        1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Hemangioma                                       1 (2%)                                                                       
      Polyp Stromal                                    2 (4%)                                                                       
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (10)                                                             
   Lymph Node, Mandibular                             (49)         (10)                                                             
   Lymph Node, Mesenteric                             (48)         (10)                                                             
   Spleen                                             (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (10)                                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                                           
      Adenoma                                          1 (100%)                                                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)                                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         4 (8%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            28                                                                           
     Total Primary Neoplasms                           37                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 22                                                                           
     Total Benign Neoplasms                            25                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              10                                                                           
     Total Malignant Neoplasms                         12                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           50           10           50           10           
  Scheduled Sacrifice                                              10                        10                         9           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14                         5                         8                        
    Natural Death                                      1                         2                         3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                35                        43                        39                        
  Other                                                                                                                 1           
  Animals Examined Microscopically                    50           10           50           10           50            9           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (10)         (49)                      (49)                      
   Intestine Small, Duodenum                          (50)         (10)         (48)                      (49)                      
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (49)         (10)         (48)                      (47)                      
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (10)         (48)                      (47)         (1)          
      Carcinoma                                                                  1 (2%)                                             
   Liver                                              (50)         (10)         (50)         (10)         (50)         (9)          
      Hemangiosarcoma                                  1 (2%)                    2 (4%)                    1 (2%)                   
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatoblastoma                                                             2 (4%)                   14 (28%)                  
      Hepatoblastoma, Multiple                                                   1 (2%)                    3 (6%)                   
      Hepatocellular Carcinoma                         5 (10%)                  11 (22%)      1 (10%)     10 (20%)                  
      Hepatocellular Carcinoma, Multiple               2 (4%)                    1 (2%)                    1 (2%)                   
      Hepatocellular Adenoma                          10 (20%)      2 (20%)     16 (32%)                  15 (30%)                  
      Hepatocellular Adenoma, Multiple                 4 (8%)                   10 (20%)                  26 (52%)                  
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Mesentery                                          (4)          (2)          (2)                       (4)                       
      Hemangioma                                       1 (25%)                                                                      
      Hepatoblastoma, Metastatic, Liver                                                                    2 (50%)                  
   Pancreas                                           (50)         (10)         (49)                      (49)                      
   Stomach, Forestomach                               (50)         (10)         (50)                      (50)                      
      Squamous Cell Papilloma                          3 (6%)                                              2 (4%)                   
   Stomach, Glandular                                 (50)         (10)         (50)                      (49)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                      (50)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (50)                      (50)                      
      Adenoma                                          5 (10%)                   3 (6%)                    2 (4%)                   
      Capsule, Adenoma                                 2 (4%)                    3 (6%)                                             
   Adrenal Gland, Medulla                             (50)         (10)         (49)                      (50)                      
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (10)         (49)                      (49)                      
      Adenoma                                          2 (4%)                    1 (2%)                                             
   Pituitary Gland                                    (47)         (8)          (46)                      (49)                      
      Pars Distalis, Adenoma                                                     1 (2%)                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (49)         (10)         (49)                      (50)                      
      Follicular Cell, Adenoma                         2 (4%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                 (1)                       
      Histiocytic Sarcoma                                                                                  1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)         (50)                      (50)                      
   Penis                                                                                                  (1)                       
      Fibrous Histiocytoma                                                                                 1 (100%)                 
   Prostate                                           (50)         (10)         (50)                      (50)                      
   Seminal Vesicle                                    (50)         (10)         (50)                      (50)                      
   Testes                                             (50)         (10)         (50)                      (50)                      
      Interstitial Cell, Adenoma                                                                           1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (50)                      (50)                      
      Hemangiosarcoma                                  2 (4%)                                                                       
   Lymph Node                                         (50)         (10)         (50)         (1)          (50)         (1)          
   Lymph Node, Mandibular                             (48)         (10)         (49)                      (49)                      
   Lymph Node, Mesenteric                             (47)         (10)         (49)         (1)          (46)         (1)          
   Spleen                                             (50)         (10)         (50)                      (49)                      
      Hemangiosarcoma                                  1 (2%)                                                                       
                                                             Page  13                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (47)         (10)         (47)                      (45)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (10)         (50)                      (50)         (1)          
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                 (1)                       
      Hepatoblastoma, Metastatic, Liver                                                                    1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (50)         (4)          (50)                      
      Alveolar/Bronchiolar Adenoma                     5 (10%)                   9 (18%)      3 (75%)      2 (4%)                   
      Alveolar/Bronchiolar Adenoma, Multiple, Two                                1 (2%)                    1 (2%)                   
      Alveolar/Bronchiolar Adenoma, Multiple, Three                                                        1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    2 (4%)       1 (25%)                               
      Hepatoblastoma, Metastatic, Liver                                                                    1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (10)                      (4)                       (2)                       
      Adenoma                                          8 (80%)                   4 (100%)                  2 (100%)                 
      Adenoma, Multiple, Two                           1 (10%)                                                                      
      Carcinoma                                        1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  14                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (50)                      (50)                      
      Renal Tubule, Adenoma                            1 (2%)                                              1 (2%)                   
   Urinary Bladder                                    (50)         (10)         (50)                      (49)                      
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(50)        *(10)        *(50)        *(9)          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         2 (4%)                    6 (12%)                   3 (6%)       1 (11%)     
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                    1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  15                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         0.0%         0.0666%      0.0666%      0.200%       0.200%          
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38           2          41           4          49           1               
     Total Primary Neoplasms                           66           2          81           5          88           1               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29           2          37           3          45                           
     Total Benign Neoplasms                            47           2          52           3          53                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16                      23           2          27           1               
     Total Malignant Neoplasms                         19                      29           2          35           1               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                                               2                           
     Total Metastatic Neoplasm                          3                                               4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  16                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10                                                               
  Scheduled Sacrifice                                              10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7                                                                            
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                40                                                                            
  Animals Examined Microscopically                    50           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (49)         (10)                                                             
   Intestine Small, Jejunum                           (50)         (10)                                                             
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (50)         (10)                                                             
      Hepatoblastoma                                   8 (16%)                                                                      
      Hepatoblastoma, Multiple                         1 (2%)                                                                       
      Hepatocellular Carcinoma                         6 (12%)                                                                      
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                          16 (32%)                                                                      
      Hepatocellular Adenoma, Multiple                13 (26%)      1 (10%)                                                         
   Pancreas                                           (50)         (10)                                                             
   Stomach, Forestomach                               (50)         (10)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Medulla                             (48)         (10)                                                             
      Pheochromocytoma Malignant                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  17                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Seminal Vesicle                                    (50)         (10)                                                             
   Testes                                             (50)         (10)                                                             
      Hemangiosarcoma                                  1 (2%)       1 (10%)                                                         
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)                                                             
   Lymph Node                                         (50)         (10)                                                             
   Lymph Node, Mesenteric                             (50)         (10)                                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (48)         (10)                                                             
   Thymus                                             (48)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (10)                                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)                                                             
      Alveolar/Bronchiolar Adenoma                     3 (6%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  18                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (1)                                                              
      Adenoma                                          3 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)                                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         2 (4%)                                                                       
      Lymphoma Malignant Undifferentiated Cell         5 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  19                                                               
NTP Experiment-Test: 05092-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94    
Route: DOSED FEED                                                                                                 Time: 19:16:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.600%       0.600%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41           2                                                               
     Total Primary Neoplasms                           67           2                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31           1                                                               
     Total Benign Neoplasms                            37           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26           1                                                               
     Total Malignant Neoplasms                         30           1                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          1                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  20                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------