TDMS Study 05092-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst O-NITROANISOLE DATE: 09/12/94
EXPERIMENT: 05092 TEST: 02 TIME: 19:33:22
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 0091-23-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst O-NITROANISOLE DATE: 09/12/94
EXPERIMENT: 05092 TEST: 02 TIME: 19:33:22
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 0091-23-6
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst O-NITROANISOLE DATE: 09/12/94
EXPERIMENT: 05092 TEST: 02 TIME: 19:33:22
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45038 ROUTE: DOSED FEED NTP C#: 60388B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 0091-23-6
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF O-NITROANISOLE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Adenoma
Harderian Gland Adenoma
Carcinoma or Adenoma
Liver Hepatoblastoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Testes Hemangiosarcoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
All Organs Histiocytic Sarcoma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 6/60 (10%) 2/59 (3%) 0/58 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 19.3% 13.5% 5.1% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/35 (17%) 5/43 (12%) 2/39 (5%) 0/39 (0%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 715 709 728 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004N** P=0.359N P=0.060N P=0.007N** | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.006N** P=0.478N P=0.070N P=0.010N* | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.005N** P=0.452N P=0.067N P=0.009N** | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.006N** | (e) |
|FISHER EXACT | P=0.500N P=0.085N P=0.007N** | (e) (e) (e) |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.1% 2.5% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 0/43 (0%) 0/39 (0%) 0/40 (0%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 312 682 564 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.179N P=0.528N P=0.515N P=0.223N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.556N P=0.251N P=0.716N P=0.718N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.220N P=0.502N P=0.559N P=0.292N |
|COCHRAN-ARMITAGE | (e) | P=0.193N |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.500N P=0.248N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.5% 0.0% 0.0% 0.0% | 0.0% 3.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/35 (3%) 0/43 (0%) 0/39 (0%) 0/40 (0%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 722 --- --- --- | --- 710 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.234N P=0.202N P=0.220N P=0.217N | P=0.541N P=0.462 (e) (e) |
|INCIDENTAL TUMOR | P=0.275N P=0.318N P=0.275N P=0.311N | P=0.863N P=0.729 (e) (e) |
|LOGISTIC REGRESSION | P=0.241N P=0.225N P=0.231N P=0.237N | P=0.570N P=0.487 (e) (e) |
|COCHRAN-ARMITAGE | P=0.239N | P=0.585N |
|FISHER EXACT | P=0.248N P=0.252N P=0.248N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 4/60 (7%) 2/59 (3%) 3/60 (5%) | 0/60 (0%) 3/60 (5%) 3/60 (5%) 1/60 (2%) |
|ADJUSTED (b) | 22.8% 9.3% 5.1% 7.0% | 0.0% 9.3% 8.7% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/35 (17%) 4/43 (9%) 2/39 (5%) 1/40 (3%) | 0/38 (0%) 1/26 (4%) 2/33 (6%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | 709 728 (T) 728 (T) 709 | --- 679 711 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.093N P=0.066N P=0.023N* P=0.053N | P=0.437N P=0.085 P=0.101 P=0.534 |
|INCIDENTAL TUMOR | P=0.129N P=0.136N P=0.032N* P=0.133N | P=0.609 P=0.228 P=0.128 P=0.534 |
|LOGISTIC REGRESSION | P=0.102N P=0.102N P=0.025N* P=0.066N | P=0.508N P=0.110 P=0.108 P=0.534 |
|COCHRAN-ARMITAGE | P=0.097N | P=0.555N |
|FISHER EXACT | P=0.120N P=0.029N* P=0.063N | P=0.122 P=0.122 P=0.500 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 4/60 (7%) 2/59 (3%) 3/60 (5%) | 1/60 (2%) 3/60 (5%) 3/60 (5%) 1/60 (2%) |
|ADJUSTED (b) | 25.4% 9.3% 5.1% 7.0% | 2.6% 9.3% 8.7% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/35 (20%) 4/43 (9%) 2/39 (5%) 1/40 (3%) | 1/38 (3%) 1/26 (4%) 2/33 (6%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | 709 728 (T) 728 (T) 709 | 728 (T) 679 711 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.065N P=0.038N* P=0.012N* P=0.031N* | P=0.306N P=0.217 P=0.261 P=0.724N |
|INCIDENTAL TUMOR | P=0.091N P=0.083N P=0.018N* P=0.081N | P=0.500N P=0.427 P=0.303 P=0.724N |
|LOGISTIC REGRESSION | P=0.072N P=0.063N P=0.014N* P=0.040N* | P=0.370N P=0.280 P=0.278 P=0.724N |
|COCHRAN-ARMITAGE | P=0.068N | P=0.418N |
|FISHER EXACT | P=0.077N P=0.016N* P=0.037N* | P=0.309 P=0.309 P=0.752N |
|=================================================================================================================================|
| |
|Intestine Small |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 0/59 (0%) 1/60 (2%) | 3/60 (5%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 6.6% 0.0% 2.5% | 7.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 2/43 (5%) 0/39 (0%) 1/40 (3%) | 1/38 (3%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- 549 --- 728 (T) | 564 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.605N P=0.150 (e) P=0.527 | P=0.115N P=0.160N P=0.142N P=0.105N |
|INCIDENTAL TUMOR | P=0.542N P=0.285 (e) P=0.527 | P=0.170N P=0.121N P=0.108N P=0.246N |
|LOGISTIC REGRESSION | P=0.617N P=0.121 (e) P=0.527 | P=0.129N P=0.123N P=0.121N P=0.120N |
|COCHRAN-ARMITAGE | P=0.613N | P=0.131N |
|FISHER EXACT | P=0.122 (e) P=0.500 | P=0.122N P=0.122N P=0.122N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 0/59 (0%) 1/60 (2%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 2.3% 0.0% 2.5% | 4.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 1/43 (2%) 0/39 (0%) 1/40 (3%) | 1/38 (3%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) --- 728 (T) | 564 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.470 P=0.541 (e) P=0.527 | P=0.217N P=0.284N P=0.260N P=0.219N |
|INCIDENTAL TUMOR | P=0.470 P=0.541 (e) P=0.527 | P=0.254N P=0.406N P=0.255N P=0.329N |
|LOGISTIC REGRESSION | P=0.470 P=0.541 (e) P=0.527 | P=0.240N P=0.238N P=0.238N P=0.241N |
|COCHRAN-ARMITAGE | P=0.460 | P=0.238N |
|FISHER EXACT | P=0.500 (e) P=0.500 | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/59 (2%) 0/58 (0%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 5.7% 2.3% 0.0% 0.0% | 4.8% 0.0% 3.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/35 (6%) 1/43 (2%) 0/39 (0%) 0/40 (0%) | 1/38 (3%) 0/26 (0%) 1/33 (3%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 728 (T) --- --- | 630 --- 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161N P=0.428N P=0.215N P=0.209N | P=0.226N P=0.281N P=0.541N P=0.217N |
|INCIDENTAL TUMOR | P=0.161N P=0.428N P=0.215N P=0.209N | P=0.261N P=0.406N P=0.533N P=0.329N |
|LOGISTIC REGRESSION | P=0.161N P=0.428N P=0.215N P=0.209N | P=0.255N P=0.242N P=0.507N P=0.234N |
|COCHRAN-ARMITAGE | P=0.169N | P=0.266N |
|FISHER EXACT | P=0.506N P=0.256N P=0.248N | P=0.248N P=0.500N P=0.248N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 1/59 (2%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.5% 4.3% 2.6% 0.0% | 2.5% 3.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/35 (3%) 1/43 (2%) 1/39 (3%) 0/40 (0%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 722 582 728 (T) --- | 722 710 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139N P=0.641N P=0.466N P=0.217N | P=0.265N P=0.690 P=0.532N P=0.477N |
|INCIDENTAL TUMOR | P=0.124N P=0.565N P=0.525N P=0.311N | P=0.562N P=0.487N P=0.419N P=0.718N |
|LOGISTIC REGRESSION | P=0.146N P=0.693N P=0.485N P=0.237N | P=0.289N P=0.744 P=0.514N P=0.485N |
|COCHRAN-ARMITAGE | P=0.143N | P=0.306N |
|FISHER EXACT | P=0.691N P=0.506N P=0.248N | P=0.752N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 17/59 (29%) 9/60 (15%) | 1/60 (2%) 1/60 (2%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 6.4% 37.1% 21.3% | 2.6% 3.3% 5.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 1/43 (2%) 11/39 (28%) 7/40 (18%) | 1/38 (3%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- 582 617 709 | 728 (T) 711 664 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019 * P=0.143 P<0.001 ** P=0.005 ** | P=0.278N P=0.684 P=0.469 P=0.466N |
|INCIDENTAL TUMOR | P=0.012 * P=0.151 P<0.001 ** P=0.002 ** | P=0.573N P=0.696N P=0.578 P=0.466N |
|LOGISTIC REGRESSION | P=0.011 * P=0.121 P<0.001 ** P=0.002 ** | P=0.314N P=0.740 P=0.491 P=0.466N |
|COCHRAN-ARMITAGE | P=0.016 * | P=0.332N |
|FISHER EXACT | P=0.122 P<0.001 ** P=0.001 ** | P=0.752N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/60 (27%) 26/60 (43%) 41/59 (69%) 30/60 (50%) | 14/60 (23%) 21/60 (35%) 38/60 (63%) 18/60 (30%) |
|ADJUSTED (b) | 38.5% 56.3% 89.0% 65.0% | 36.8% 61.7% 84.1% 39.1% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 0/10 (0%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 1/10 (10%) 2/10 (20%) 0/10 (0%) |
|TERMINAL (d) | 11/35 (31%) 23/43 (53%) 34/39 (87%) 24/40 (60%) | 14/38 (37%) 14/26 (54%) 26/33 (79%) 17/45 (38%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 549 617 455 (I) | 728 (T) 456 (I) 455 (I) 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.050 P=0.156 P<0.001 ** P=0.025 * | P=0.108N P=0.007 ** P<0.001 ** P=0.473 |
|INCIDENTAL TUMOR | P=0.017 * P=0.081 P<0.001 ** P=0.003 ** | P=0.373N P=0.021 * P<0.001 ** P=0.422 |
|LOGISTIC REGRESSION | P=0.015 * P=0.042 * P<0.001 ** P=0.004 ** | P=0.413N P=0.066 P<0.001 ** P=0.412 |
|COCHRAN-ARMITAGE | P=0.036 * | P=0.527 |
|FISHER EXACT | P=0.042 * P<0.001 ** P=0.007 ** | P=0.114 P<0.001 ** P=0.268 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 13/60 (22%) 11/59 (19%) 7/60 (12%) | 5/60 (8%) 2/60 (3%) 8/60 (13%) 3/60 (5%) |
|ADJUSTED (b) | 16.3% 27.2% 25.5% 16.7% | 12.6% 5.1% 21.8% 6.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/35 (9%) 9/43 (21%) 8/39 (21%) 5/40 (13%) | 4/38 (11%) 0/26 (0%) 5/33 (15%) 3/45 (7%) |
|FIRST INCIDENCE (DAYS) | 647 455 (I) 626 710 | 693 619 686 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.272N P=0.202 P=0.271 P=0.558N | P=0.260N P=0.336N P=0.208 P=0.274N |
|INCIDENTAL TUMOR | P=0.372N P=0.033 * P=0.234 P=0.397 | P=0.499N P=0.229N P=0.290 P=0.342N |
|LOGISTIC REGRESSION | P=0.301N P=0.114 P=0.224 P=0.598 | P=0.361N P=0.238N P=0.236 P=0.312N |
|COCHRAN-ARMITAGE | P=0.280N | P=0.430N |
|FISHER EXACT | P=0.110 P=0.210 P=0.611N | P=0.219N P=0.279 P=0.359N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 15/60 (25%) 23/59 (39%) 15/60 (25%) | 6/60 (10%) 3/60 (5%) 9/60 (15%) 3/60 (5%) |
|ADJUSTED (b) | 16.3% 30.3% 48.4% 34.9% | 15.2% 8.3% 23.7% 6.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/35 (9%) 9/43 (21%) 15/39 (38%) 12/40 (30%) | 5/38 (13%) 0/26 (0%) 5/33 (15%) 3/45 (7%) |
|FIRST INCIDENCE (DAYS) | 647 455 (I) 617 709 | 693 619 664 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.211 P=0.110 P=0.003 ** P=0.082 | P=0.158N P=0.397N P=0.217 P=0.172N |
|INCIDENTAL TUMOR | P=0.105 P=0.013 * P<0.001 ** P=0.014 * | P=0.406N P=0.216N P=0.312 P=0.221N |
|LOGISTIC REGRESSION | P=0.144 P=0.027 * P<0.001 ** P=0.040 * | P=0.236N P=0.272N P=0.249 P=0.202N |
|COCHRAN-ARMITAGE | P=0.186 | P=0.295N |
|FISHER EXACT | P=0.049 * P<0.001 ** P=0.049 * | P=0.245N P=0.291 P=0.245N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/60 (38%) 33/60 (55%) 45/59 (76%) 33/60 (55%) | 17/60 (28%) 22/60 (37%) 39/60 (65%) 20/60 (33%) |
|ADJUSTED (b) | 50.8% 65.9% 91.8% 71.6% | 43.5% 62.9% 86.4% 43.5% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 1/10 (10%) 2/10 (20%) 0/10 (0%) |
|TERMINAL (d) | 14/35 (40%) 26/43 (60%) 35/39 (90%) 27/40 (68%) | 16/38 (42%) 14/26 (54%) 27/33 (82%) 19/45 (42%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 617 455 (I) | 693 456 (I) 455 (I) 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.223 P=0.227 P<0.001 ** P=0.135 | P=0.088N P=0.020 * P<0.001 ** P=0.577N |
|INCIDENTAL TUMOR | P=0.073 P=0.030 * P<0.001 ** P=0.014 * | P=0.370N P=0.080 P<0.001 ** P=0.496 |
|LOGISTIC REGRESSION | P=0.092 P=0.048 * P<0.001 ** P=0.030 * | P=0.388N P=0.140 P<0.001 ** P=0.489 |
|COCHRAN-ARMITAGE | P=0.163 | P=0.537 |
|FISHER EXACT | P=0.050 * P<0.001 ** P=0.050 * | P=0.218 P<0.001 ** P=0.346 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/60 (38%) 34/60 (57%) 46/59 (78%) 35/60 (58%) | 17/60 (28%) 23/60 (38%) 39/60 (65%) 20/60 (33%) |
|ADJUSTED (b) | 50.8% 66.6% 93.8% 75.9% | 43.5% 64.1% 86.4% 43.5% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 1/10 (10%) 2/10 (20%) 0/10 (0%) |
|TERMINAL (d) | 14/35 (40%) 26/43 (60%) 36/39 (92%) 29/40 (73%) | 16/38 (42%) 14/26 (54%) 27/33 (82%) 19/45 (42%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 617 455 (I) | 693 456 (I) 455 (I) 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.142 P=0.182 P<0.001 ** P=0.076 | P=0.076N P=0.012 * P<0.001 ** P=0.577N |
|INCIDENTAL TUMOR | P=0.036 * P=0.030 * P<0.001 ** P=0.005 ** | P=0.358N P=0.067 P<0.001 ** P=0.496 |
|LOGISTIC REGRESSION | P=0.041 * P=0.020 * P<0.001 ** P=0.011 * | P=0.353N P=0.099 P<0.001 ** P=0.489 |
|COCHRAN-ARMITAGE | P=0.093 | P=0.519N |
|FISHER EXACT | P=0.034 * P<0.001 ** P=0.022 * | P=0.166 P<0.001 ** P=0.346 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 13/60 (22%) 4/59 (7%) 3/60 (5%) | 5/60 (8%) 2/60 (3%) 4/60 (7%) 0/60 (0%) |
|ADJUSTED (b) | 14.3% 25.1% 9.0% 7.5% | 11.7% 6.3% 9.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 3/10 (30%) 0/9 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 5/35 (14%) 6/43 (14%) 2/39 (5%) 3/40 (8%) | 3/38 (8%) 1/26 (4%) 2/33 (6%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 455 (I) 617 728 (T) | 456 (I) 691 445 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055N P=0.076 P=0.447N P=0.284N | P=0.032N* P=0.330N P=0.550N P=0.026N* |
|INCIDENTAL TUMOR | P=0.052N P=0.048 * P=0.334N P=0.284N | P=0.043N* P=0.176N P=0.428N P=0.041N* |
|LOGISTIC REGRESSION | P=0.058N P=0.037 * P=0.494N P=0.284N | P=0.050N* P=0.225N P=0.504N P=0.033N* |
|COCHRAN-ARMITAGE | P=0.056N | P=0.049N* |
|FISHER EXACT | P=0.036 * P=0.511N P=0.359N | P=0.219N P=0.500N P=0.029N* |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 0/59 (0%) 1/60 (2%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.1% 6.3% 0.0% 2.5% | 5.3% 2.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 1/43 (2%) 0/39 (0%) 1/40 (3%) | 2/38 (5%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 652 457 (I) --- 728 (T) | 728 (T) 648 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.434N P=0.337 P=0.500N P=0.750N | P=0.142N P=0.587N P=0.270N P=0.202N |
|INCIDENTAL TUMOR | P=0.503N P=0.160 P=0.588N P=0.689 | P=0.177N P=0.464N P=0.270N P=0.202N |
|LOGISTIC REGRESSION | P=0.427N P=0.302 P=0.507N P=0.759 | P=0.161N P=0.517N P=0.270N P=0.202N |
|COCHRAN-ARMITAGE | P=0.436N | P=0.169N |
|FISHER EXACT | P=0.309 P=0.504N P=0.752N | P=0.500N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 16/60 (27%) 4/59 (7%) 4/60 (7%) | 7/60 (12%) 3/60 (5%) 4/60 (7%) 0/60 (0%) |
|ADJUSTED (b) | 16.1% 30.2% 9.0% 10.0% | 16.7% 8.4% 9.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 4/10 (40%) 0/9 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 5/35 (14%) 7/43 (16%) 2/39 (5%) 4/40 (10%) | 5/38 (13%) 1/26 (4%) 2/33 (6%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 652 455 (I) 617 728 (T) | 456 (I) 648 445 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.045N* P=0.043 * P=0.325N P=0.299N | P=0.009N** P=0.282N P=0.321N P=0.006N** |
|INCIDENTAL TUMOR | P=0.048N* P=0.012 * P=0.249N P=0.343N | P=0.013N* P=0.117N P=0.224N P=0.010N** |
|LOGISTIC REGRESSION | P=0.045N* P=0.017 * P=0.367N P=0.380N | P=0.015N* P=0.170N P=0.264N P=0.009N** |
|COCHRAN-ARMITAGE | P=0.044N* | P=0.015N* |
|FISHER EXACT | P=0.016 * P=0.382N P=0.372N | P=0.161N P=0.264N P=0.006N** |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Ovary |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/59 (3%) 1/60 (2%) 0/58 (0%) 1/60 (2%) |
|ADJUSTED (b) | | 4.4% 3.8% 0.0% 2.2% |
|INTERIM SACRIFICE 1 (c)| | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/37 (3%) 1/26 (4%) 0/32 (0%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | | 455 (I) 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.417N P=0.581N P=0.256N P=0.455N |
|INCIDENTAL TUMOR | | P=0.417N P=0.581N P=0.256N P=0.455N |
|LOGISTIC REGRESSION | | P=0.494N P=0.493N P=0.249N P=0.505N |
|COCHRAN-ARMITAGE | | P=0.496N |
|FISHER EXACT | | P=0.494N P=0.252N P=0.494N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/57 (0%) 1/56 (2%) 0/58 (0%) 0/58 (0%) | 8/59 (14%) 6/57 (11%) 8/58 (14%) 0/58 (0%) |
|ADJUSTED (b) | 0.0% 2.2% 0.0% 0.0% | 20.5% 21.7% 22.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/40 (0%) 0/38 (0%) 0/39 (0%) | 7/37 (19%) 4/24 (17%) 6/32 (19%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | --- 710 --- --- | 457 (I) 704 546 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.589N P=0.523 (e) (e) | P=0.002N** P=0.549 P=0.496 P=0.003N** |
|INCIDENTAL TUMOR | P=0.676N P=0.295 (e) (e) | P=0.003N** P=0.541N P=0.594 P=0.003N** |
|LOGISTIC REGRESSION | P=0.583N P=0.502 (e) (e) | P=0.005N** P=0.466N P=0.570 P=0.005N** |
|COCHRAN-ARMITAGE | P=0.581N | P=0.007N** |
|FISHER EXACT | P=0.496 (e) (e) | P=0.415N P=0.591 P=0.003N** |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/57 (0%) 1/56 (2%) 0/58 (0%) 0/58 (0%) | 8/59 (14%) 6/57 (11%) 9/58 (16%) 0/58 (0%) |
|ADJUSTED (b) | 0.0% 2.2% 0.0% 0.0% | 20.5% 21.7% 24.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/40 (0%) 0/38 (0%) 0/39 (0%) | 7/37 (19%) 4/24 (17%) 6/32 (19%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | --- 710 --- --- | 457 (I) 704 456 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.589N P=0.523 (e) (e) | P=0.002N** P=0.549 P=0.393 P=0.003N** |
|INCIDENTAL TUMOR | P=0.676N P=0.295 (e) (e) | P=0.004N** P=0.541N P=0.486 P=0.003N** |
|LOGISTIC REGRESSION | P=0.583N P=0.502 (e) (e) | P=0.006N** P=0.466N P=0.474 P=0.005N** |
|COCHRAN-ARMITAGE | P=0.581N | P=0.008N** |
|FISHER EXACT | P=0.496 (e) (e) | P=0.415N P=0.485 P=0.003N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/57 (0%) 1/56 (2%) 0/58 (0%) 0/58 (0%) | 1/59 (2%) 1/57 (2%) 3/58 (5%) 0/58 (0%) |
|ADJUSTED (b) | 0.0% 2.5% 0.0% 0.0% | 2.7% 4.2% 9.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 1/40 (3%) 0/38 (0%) 0/39 (0%) | 1/37 (3%) 1/24 (4%) 3/32 (9%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) --- --- | 728 (T) 728 (T) 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.569N P=0.545 (e) (e) | P=0.247N P=0.662 P=0.254 P=0.470N |
|INCIDENTAL TUMOR | P=0.569N P=0.545 (e) (e) | P=0.247N P=0.662 P=0.254 P=0.470N |
|LOGISTIC REGRESSION | P=0.569N P=0.545 (e) (e) | P=0.247N P=0.662 P=0.254 P=0.470N |
|COCHRAN-ARMITAGE | P=0.581N | P=0.338N |
|FISHER EXACT | P=0.496 (e) (e) | P=0.743 P=0.303 P=0.504N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/58 (0%) 0/58 (0%) | 0/60 (0%) 2/60 (3%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 0.0% 0.0% | 0.0% 5.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/35 (3%) 0/43 (0%) 0/38 (0%) 0/38 (0%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- --- | --- 676 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.472N P=0.459N P=0.484N P=0.484N | P=0.348N P=0.216 (e) (e) |
|INCIDENTAL TUMOR | P=0.472N P=0.459N P=0.484N P=0.484N | P=0.695N P=0.513 (e) (e) |
|LOGISTIC REGRESSION | P=0.472N P=0.459N P=0.484N P=0.484N | P=0.370N P=0.230 (e) (e) |
|COCHRAN-ARMITAGE | P=0.477N | P=0.380N |
|FISHER EXACT | P=0.500N P=0.508N P=0.508N | P=0.248 (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 2/59 (3%) 1/60 (2%) | 3/60 (5%) 1/60 (2%) 6/60 (10%) 2/60 (3%) |
|ADJUSTED (b) | 8.0% 0.0% 4.7% 2.5% | 7.5% 3.8% 16.2% 4.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/35 (6%) 0/43 (0%) 1/39 (3%) 1/40 (3%) | 2/38 (5%) 1/26 (4%) 4/33 (12%) 2/45 (4%) |
|FIRST INCIDENCE (DAYS) | 710 --- 708 728 (T) | 705 728 (T) 546 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.422N P=0.094N P=0.471N P=0.270N | P=0.377N P=0.432N P=0.194 P=0.429N |
|INCIDENTAL TUMOR | P=0.485N P=0.147N P=0.550N P=0.340N | P=0.478N P=0.305N P=0.315 P=0.530N |
|LOGISTIC REGRESSION | P=0.441N P=0.114N P=0.493N P=0.308N | P=0.486N P=0.354N P=0.229 P=0.463N |
|COCHRAN-ARMITAGE | P=0.429N | P=0.534N |
|FISHER EXACT | P=0.122N P=0.508N P=0.309N | P=0.309N P=0.245 P=0.500N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Testes |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 2/60 (3%) | |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 4.2% | |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/10 (10%) | |
|TERMINAL (d) | 0/35 (0%) 0/43 (0%) 0/39 (0%) 1/40 (3%) | |
|FIRST INCIDENCE (DAYS) | --- --- --- 455 (I) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.045 * (e) (e) P=0.254 | |
|INCIDENTAL TUMOR | P=0.045 * (e) (e) P=0.254 | |
|LOGISTIC REGRESSION | P=0.054 (e) (e) P=0.258 | |
|COCHRAN-ARMITAGE | P=0.042 * | |
|FISHER EXACT | (e) (e) P=0.248 | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/59 (3%) 2/59 (3%) 0/59 (0%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.7% 4.7% 0.0% 0.0% | 2.6% 3.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/35 (6%) 2/43 (5%) 0/39 (0%) 0/40 (0%) | 1/38 (3%) 1/26 (4%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 728 (T) --- --- | 728 (T) 728 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.116N P=0.619N P=0.215N P=0.209N | P=0.256N P=0.675 P=0.528N P=0.466N |
|INCIDENTAL TUMOR | P=0.116N P=0.619N P=0.215N P=0.209N | P=0.256N P=0.675 P=0.528N P=0.466N |
|LOGISTIC REGRESSION | P=0.116N P=0.619N P=0.215N P=0.209N | P=0.256N P=0.675 P=0.528N P=0.466N |
|COCHRAN-ARMITAGE | P=0.122N | P=0.306N |
|FISHER EXACT | P=0.691N P=0.248N P=0.244N | P=0.752N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/60 (5%) 5/60 (8%) 4/60 (7%) 2/60 (3%) |
|ADJUSTED (b) | | 7.9% 16.3% 12.1% 4.4% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 3/38 (8%) 2/26 (8%) 4/33 (12%) 2/45 (4%) |
|FIRST INCIDENCE (DAYS) | | 728 (T) 695 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.154N P=0.197 P=0.423 P=0.423N |
|INCIDENTAL TUMOR | | P=0.250N P=0.441 P=0.423 P=0.423N |
|LOGISTIC REGRESSION | | P=0.206N P=0.296 P=0.423 P=0.423N |
|COCHRAN-ARMITAGE | | P=0.277N |
|FISHER EXACT | | P=0.359 P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 2/60 (3%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | | 0.0% 5.4% 0.0% 2.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/38 (0%) 0/26 (0%) 0/33 (0%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | | --- 455 (I) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.662 P=0.197 (e) P=0.534 |
|INCIDENTAL TUMOR | | P=0.555 P=0.358 (e) P=0.534 |
|LOGISTIC REGRESSION | | P=0.607 P=0.237 (e) P=0.534 |
|COCHRAN-ARMITAGE | | P=0.615 |
|FISHER EXACT | | P=0.248 (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/60 (5%) 6/60 (10%) 4/60 (7%) 3/60 (5%) |
|ADJUSTED (b) | | 7.9% 17.8% 12.1% 6.7% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 3/38 (8%) 2/26 (8%) 4/33 (12%) 3/45 (7%) |
|FIRST INCIDENCE (DAYS) | | 728 (T) 455 (I) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.227N P=0.126 P=0.423 P=0.583N |
|INCIDENTAL TUMOR | | P=0.344N P=0.308 P=0.423 P=0.583N |
|LOGISTIC REGRESSION | | P=0.335N P=0.228 P=0.423 P=0.583N |
|COCHRAN-ARMITAGE | | P=0.383N |
|FISHER EXACT | | P=0.245 P=0.500 P=0.660N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/59 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 2.2% 2.3% 0.0% 0.0% | 5.3% 2.7% 0.0% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 1/43 (2%) 0/39 (0%) 0/40 (0%) | 2/38 (5%) 0/26 (0%) 0/33 (0%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | 709 728 (T) --- --- | 728 (T) 700 --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.308N P=0.730N P=0.509N P=0.509N | P=0.409N P=0.602N P=0.270N P=0.441N |
|INCIDENTAL TUMOR | P=0.349N P=0.682 P=0.588N P=0.669N | P=0.501N P=0.464N P=0.270N P=0.441N |
|LOGISTIC REGRESSION | P=0.310N P=0.757N P=0.499N P=0.504N | P=0.458N P=0.536N P=0.270N P=0.441N |
|COCHRAN-ARMITAGE | P=0.306N | P=0.500N |
|FISHER EXACT | P=0.752N P=0.504N P=0.500N | P=0.500N P=0.248N P=0.500N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 2/60 (3%) 1/59 (2%) 3/60 (5%) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 8.3% 4.3% 2.6% 6.2% | 2.5% 5.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/35 (6%) 1/43 (2%) 1/39 (3%) 1/40 (3%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | 722 582 728 (T) 455 (I) | 722 676 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.518 P=0.431N P=0.272N P=0.626N | P=0.185N P=0.426 P=0.532N P=0.477N |
|INCIDENTAL TUMOR | P=0.579 P=0.332N P=0.315N P=0.537N | P=0.461N P=0.622N P=0.419N P=0.718N |
|LOGISTIC REGRESSION | P=0.518 P=0.496N P=0.285N P=0.662N | P=0.204N P=0.483 P=0.514N P=0.485N |
|COCHRAN-ARMITAGE | P=0.510 | P=0.215N |
|FISHER EXACT | P=0.500N P=0.316N P=0.660N | P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 3/60 (5%) 1/59 (2%) 3/60 (5%) | 3/60 (5%) 3/60 (5%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 10.3% 6.6% 2.6% 6.2% | 7.6% 7.9% 0.0% 2.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/35 (6%) 2/43 (5%) 1/39 (3%) 1/40 (3%) | 2/38 (5%) 0/26 (0%) 0/33 (0%) 1/45 (2%) |
|FIRST INCIDENCE (DAYS) | 709 582 728 (T) 455 (I) | 722 676 --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.502N P=0.421N P=0.163N P=0.470N | P=0.143N P=0.540 P=0.150N P=0.253N |
|INCIDENTAL TUMOR | P=0.469N P=0.420N P=0.213N P=0.432N | P=0.330N P=0.369N P=0.114N P=0.347N |
|LOGISTIC REGRESSION | P=0.505N P=0.494N P=0.173N P=0.502N | P=0.173N P=0.633 P=0.136N P=0.268N |
|COCHRAN-ARMITAGE | P=0.508N | P=0.197N |
|FISHER EXACT | P=0.500N P=0.187N P=0.500N | P=0.660N P=0.122N P=0.309N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 1/60 (2%) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% 2.5% | 5.0% 0.0% 3.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 0/43 (0%) 0/39 (0%) 1/40 (3%) | 0/38 (0%) 0/26 (0%) 1/33 (3%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 722 728 (T) | 722 --- 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.312 (e) P=0.516 P=0.527 | P=0.215N P=0.337N P=0.554N P=0.213N |
|INCIDENTAL TUMOR | P=0.253 (e) P=0.412 P=0.527 | P=0.392N P=0.042N* P=0.422N P=0.500N |
|LOGISTIC REGRESSION | P=0.299 (e) P=0.504 P=0.527 | P=0.236N P=0.265N P=0.527N P=0.220N |
|COCHRAN-ARMITAGE | P=0.306 | P=0.266N |
|FISHER EXACT | (e) P=0.496 P=0.500 | P=0.248N P=0.500N P=0.248N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 7/60 (12%) 5/59 (8%) 9/60 (15%) | 7/60 (12%) 14/60 (23%) 15/60 (25%) 5/60 (8%) |
|ADJUSTED (b) | 10.2% 15.4% 11.3% 19.6% | 17.1% 41.3% 38.2% 10.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/9 (11%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/35 (6%) 5/43 (12%) 2/39 (5%) 4/40 (10%) | 4/38 (11%) 8/26 (31%) 10/33 (30%) 4/45 (9%) |
|FIRST INCIDENCE (DAYS) | 703 709 457 (I) 576 | 708 646 539 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140 P=0.366 P=0.529 P=0.154 | P=0.028N* P=0.017 * P=0.029 * P=0.281N |
|INCIDENTAL TUMOR | P=0.063 P=0.144 P=0.402 P=0.050 | P=0.155N P=0.169 P=0.067 P=0.543N |
|LOGISTIC REGRESSION | P=0.114 P=0.279 P=0.496 P=0.111 | P=0.123N P=0.045 * P=0.037 * P=0.322N |
|COCHRAN-ARMITAGE | P=0.129 | P=0.099N |
|FISHER EXACT | P=0.264 P=0.489 P=0.120 | P=0.074 P=0.049 * P=0.381N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 7/60 (12%) 5/59 (8%) 8/60 (13%) | 5/60 (8%) 14/60 (23%) 14/60 (23%) 5/60 (8%) |
|ADJUSTED (b) | 10.2% 15.4% 11.3% 17.3% | 12.7% 41.3% 35.5% 10.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/9 (11%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/35 (6%) 5/43 (12%) 2/39 (5%) 3/40 (8%) | 4/38 (11%) 8/26 (31%) 9/33 (27%) 4/45 (9%) |
|FIRST INCIDENCE (DAYS) | 703 709 457 (I) 576 | 708 646 539 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.223 P=0.366 P=0.529 P=0.216 | P=0.054N P=0.004 ** P=0.013 * P=0.523N |
|INCIDENTAL TUMOR | P=0.116 P=0.144 P=0.402 P=0.081 | P=0.212N P=0.035 * P=0.028 * P=0.591 |
|LOGISTIC REGRESSION | P=0.195 P=0.279 P=0.496 P=0.170 | P=0.209N P=0.012 * P=0.017 * P=0.577N |
|COCHRAN-ARMITAGE | P=0.212 | P=0.162N |
|FISHER EXACT | P=0.264 P=0.489 P=0.181 | P=0.022 * P=0.022 * P=0.628N |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.1% 2.5% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 0/43 (0%) 0/39 (0%) 0/40 (0%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 312 682 564 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.179N P=0.528N P=0.515N P=0.223N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.556N P=0.251N P=0.716N P=0.718N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.220N P=0.502N P=0.559N P=0.292N |
|COCHRAN-ARMITAGE | (e) | P=0.193N |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.500N P=0.248N |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.1% 2.5% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/35 (0%) 0/43 (0%) 0/39 (0%) 0/40 (0%) | 0/38 (0%) 0/26 (0%) 0/33 (0%) 0/45 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 312 682 564 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.179N P=0.528N P=0.515N P=0.223N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.556N P=0.251N P=0.716N P=0.718N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.220N P=0.502N P=0.559N P=0.292N |
|COCHRAN-ARMITAGE | (e) | P=0.193N |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.500N P=0.248N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 31/60 (52%) 40/60 (67%) 45/59 (76%) 32/60 (53%) | 34/60 (57%) 32/60 (53%) 46/60 (77%) 22/60 (37%) |
|ADJUSTED (b) | 69.7% 75.3% 95.7% 69.4% | 74.9% 81.3% 95.8% 47.8% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 3/10 (30%) 0/9 (0%) 1/10 (10%) | 3/10 (30%) 1/10 (10%) 3/10 (30%) 0/10 (0%) |
|TERMINAL (d) | 22/35 (63%) 30/43 (70%) 37/39 (95%) 26/40 (65%) | 27/38 (71%) 19/26 (73%) 31/33 (94%) 21/45 (47%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 617 455 (I) | 312 456 (I) 445 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.226N P=0.359 P=0.032 * P=0.420N | P<0.001N** P=0.118 P=0.003 ** P=0.002N** |
|INCIDENTAL TUMOR | P=0.363N P=0.102 P=0.003 ** P=0.373 | P=0.001N** P=0.511 P=0.003 ** P=0.008N** |
|LOGISTIC REGRESSION | P=0.349N P=0.065 P=0.002 ** P=0.440 | P=0.001N** P=0.497N P=0.004 ** P=0.010N** |
|COCHRAN-ARMITAGE | P=0.282N | P=0.008N** |
|FISHER EXACT | P=0.068 P=0.004 ** P=0.500 | P=0.427N P=0.016 * P=0.022N* |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0.0% 0.0666% 0.200% 0.600% | 0.0% 0.0666% 0.200% 0.600% |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 16/60 (27%) 25/60 (42%) 28/59 (47%) 27/60 (45%) | 21/60 (35%) 28/60 (47%) 25/60 (42%) 10/60 (17%) |
|ADJUSTED (b) | 36.0% 47.9% 56.8% 53.9% | 45.9% 58.5% 56.0% 21.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 1/9 (11%) 1/10 (10%) | 1/10 (10%) 1/10 (10%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 8/35 (23%) 16/43 (37%) 18/39 (46%) 17/40 (43%) | 14/38 (37%) 8/26 (31%) 14/33 (42%) 9/45 (20%) |
|FIRST INCIDENCE (DAYS) | 647 455 (I) 457 (I) 455 (I) | 312 331 456 (I) 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120 P=0.190 P=0.051 P=0.075 | P<0.001N** P=0.034 * P=0.175 P=0.007N** |
|INCIDENTAL TUMOR | P=0.033 * P=0.019 * P=0.012 * P=0.006 ** | P=0.019N* P=0.424 P=0.265 P=0.038N* |
|LOGISTIC REGRESSION | P=0.033 * P=0.017 * P=0.010 ** P=0.006 ** | P<0.001N** P=0.122 P=0.269 P=0.013N* |
|COCHRAN-ARMITAGE | P=0.082 | P=0.001N** |
|FISHER EXACT | P=0.062 P=0.015 * P=0.028 * | P=0.133 P=0.287 P=0.018N* |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 40/60 (67%) 45/60 (75%) 50/59 (85%) 43/60 (72%) | 43/60 (72%) 46/60 (77%) 51/60 (85%) 28/60 (47%) |
|ADJUSTED (b) | 79.8% 83.2% 98.0% 84.2% | 85.8% 91.8% 100.0% 60.9% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 4/10 (40%) 1/9 (11%) 2/10 (20%) | 4/10 (40%) 2/10 (20%) 4/10 (40%) 0/10 (0%) |
|TERMINAL (d) | 25/35 (71%) 34/43 (79%) 38/39 (97%) 32/40 (80%) | 31/38 (82%) 22/26 (85%) 33/33 (100%) 27/45 (60%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 457 (I) 455 (I) | 312 331 445 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.506N P=0.452N P=0.169 P=0.521N | P<0.001N** P=0.017 * P=0.017 * P<0.001N** |
|INCIDENTAL TUMOR | P=0.336 P=0.156 P=0.009 ** P=0.192 | P<0.001N** P=0.392 P=0.023 * P=0.002N** |
|LOGISTIC REGRESSION | P=0.333 P=0.207 P=0.010 ** P=0.194 | P<0.001N** P=0.277 P=0.042 * P=0.001N** |
|COCHRAN-ARMITAGE | P=0.495 | P<0.001N** |
|FISHER EXACT | P=0.211 P=0.018 * P=0.346 | P=0.339 P=0.060 P=0.004N** |
|=================================================================================================================================|
DATE: 09/12/94 EXPERIMENT: 05092 TEST: 02 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
TERMINAL SACRIFICE AT 104 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 455
Female interim sacrifices(days): 455
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).