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TDMS Study 05092-02 Pathology Tables


NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROANISOLE                                    DATE: 09/12/94       
EXPERIMENT: 05092 TEST: 02                                                                                     TIME: 19:33:22       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-45038          ROUTE: DOSED FEED                                                                  NTP C#: 60388B       
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 0091-23-6       
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Southern Research Inst                                  O-NITROANISOLE                                    DATE: 09/12/94      
EXPERIMENT: 05092 TEST: 02                                                                                     TIME: 19:33:22      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-45038          ROUTE: DOSED FEED                                                                  NTP C#: 60388B      
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 0091-23-6      
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                    ----------------
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROANISOLE                                    DATE: 09/12/94       
EXPERIMENT: 05092 TEST: 02                                                                                     TIME: 19:33:22       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-45038          ROUTE: DOSED FEED                                                                  NTP C#: 60388B       
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 0091-23-6       
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF O-NITROANISOLE
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Adrenal Cortex                Adenoma
                             Harderian Gland               Adenoma
                                                           Carcinoma or Adenoma
                             Liver                         Hepatoblastoma
                                                           Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatoblastoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Testes                        Hemangiosarcoma
                             All Organs                    Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             All Organs                    Histiocytic Sarcoma
                                                           Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   1
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)   6/60 (10%)   2/59 (3%)    0/58 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  19.3%        13.5%         5.1%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  6/35 (17%)   5/43 (12%)   2/39 (5%)    0/39 (0%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   715          709          728 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.004N**   P=0.359N     P=0.060N     P=0.007N** |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.006N**   P=0.478N     P=0.070N     P=0.010N*  |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.005N**   P=0.452N     P=0.067N     P=0.009N** |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.006N**                                        |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.085N     P=0.007N** |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |  2/60 (3%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.1%         2.5%         2.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    0/43 (0%)    0/39 (0%)    0/40 (0%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   312          682          564          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.179N     P=0.528N     P=0.515N     P=0.223N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.556N     P=0.251N     P=0.716N     P=0.718N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.220N     P=0.502N     P=0.559N     P=0.292N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.193N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   2
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.5%         0.0%         0.0%         0.0%      |   0.0%         3.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/35 (3%)    0/43 (0%)    0/39 (0%)    0/40 (0%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   722          ---          ---          ---       |   ---          710          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.234N     P=0.202N     P=0.220N     P=0.217N   |  P=0.541N     P=0.462        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.275N     P=0.318N     P=0.275N     P=0.311N   |  P=0.863N     P=0.729        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.241N     P=0.225N     P=0.231N     P=0.237N   |  P=0.570N     P=0.487        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.239N                                          |  P=0.585N                                          |
|FISHER EXACT           |               P=0.248N     P=0.252N     P=0.248N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/60 (15%)   4/60 (7%)    2/59 (3%)    3/60 (5%)  |  0/60 (0%)    3/60 (5%)    3/60 (5%)    1/60 (2%)  |
|ADJUSTED (b)           |  22.8%         9.3%         5.1%         7.0%      |   0.0%         9.3%         8.7%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  6/35 (17%)   4/43 (9%)    2/39 (5%)    1/40 (3%)  |  0/38 (0%)    1/26 (4%)    2/33 (6%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   709          728 (T)      728 (T)      709       |   ---          679          711          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.093N     P=0.066N     P=0.023N*    P=0.053N   |  P=0.437N     P=0.085      P=0.101      P=0.534    |
|INCIDENTAL TUMOR       |  P=0.129N     P=0.136N     P=0.032N*    P=0.133N   |  P=0.609      P=0.228      P=0.128      P=0.534    |
|LOGISTIC REGRESSION    |  P=0.102N     P=0.102N     P=0.025N*    P=0.066N   |  P=0.508N     P=0.110      P=0.108      P=0.534    |
|COCHRAN-ARMITAGE       |  P=0.097N                                          |  P=0.555N                                          |
|FISHER EXACT           |               P=0.120N     P=0.029N*    P=0.063N   |               P=0.122      P=0.122      P=0.500    |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   3
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)   4/60 (7%)    2/59 (3%)    3/60 (5%)  |  1/60 (2%)    3/60 (5%)    3/60 (5%)    1/60 (2%)  |
|ADJUSTED (b)           |  25.4%         9.3%         5.1%         7.0%      |   2.6%         9.3%         8.7%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  7/35 (20%)   4/43 (9%)    2/39 (5%)    1/40 (3%)  |  1/38 (3%)    1/26 (4%)    2/33 (6%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   709          728 (T)      728 (T)      709       |   728 (T)      679          711          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.065N     P=0.038N*    P=0.012N*    P=0.031N*  |  P=0.306N     P=0.217      P=0.261      P=0.724N   |
|INCIDENTAL TUMOR       |  P=0.091N     P=0.083N     P=0.018N*    P=0.081N   |  P=0.500N     P=0.427      P=0.303      P=0.724N   |
|LOGISTIC REGRESSION    |  P=0.072N     P=0.063N     P=0.014N*    P=0.040N*  |  P=0.370N     P=0.280      P=0.278      P=0.724N   |
|COCHRAN-ARMITAGE       |  P=0.068N                                          |  P=0.418N                                          |
|FISHER EXACT           |               P=0.077N     P=0.016N*    P=0.037N*  |               P=0.309      P=0.309      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    3/60 (5%)    0/59 (0%)    1/60 (2%)  |  3/60 (5%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         6.6%         0.0%         2.5%      |   7.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    2/43 (5%)    0/39 (0%)    1/40 (3%)  |  1/38 (3%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          549          ---          728 (T)   |   564          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.605N     P=0.150        (e)        P=0.527    |  P=0.115N     P=0.160N     P=0.142N     P=0.105N   |
|INCIDENTAL TUMOR       |  P=0.542N     P=0.285        (e)        P=0.527    |  P=0.170N     P=0.121N     P=0.108N     P=0.246N   |
|LOGISTIC REGRESSION    |  P=0.617N     P=0.121        (e)        P=0.527    |  P=0.129N     P=0.123N     P=0.121N     P=0.120N   |
|COCHRAN-ARMITAGE       |  P=0.613N                                          |  P=0.131N                                          |
|FISHER EXACT           |               P=0.122        (e)        P=0.500    |               P=0.122N     P=0.122N     P=0.122N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   4
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    0/59 (0%)    1/60 (2%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         2.3%         0.0%         2.5%      |   4.7%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    1/43 (2%)    0/39 (0%)    1/40 (3%)  |  1/38 (3%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          728 (T)      ---          728 (T)   |   564          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.470      P=0.541        (e)        P=0.527    |  P=0.217N     P=0.284N     P=0.260N     P=0.219N   |
|INCIDENTAL TUMOR       |  P=0.470      P=0.541        (e)        P=0.527    |  P=0.254N     P=0.406N     P=0.255N     P=0.329N   |
|LOGISTIC REGRESSION    |  P=0.470      P=0.541        (e)        P=0.527    |  P=0.240N     P=0.238N     P=0.238N     P=0.241N   |
|COCHRAN-ARMITAGE       |  P=0.460                                           |  P=0.238N                                          |
|FISHER EXACT           |               P=0.500        (e)        P=0.500    |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/59 (2%)    0/58 (0%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.7%         2.3%         0.0%         0.0%      |   4.8%         0.0%         3.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/35 (6%)    1/43 (2%)    0/39 (0%)    0/40 (0%)  |  1/38 (3%)    0/26 (0%)    1/33 (3%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   728 (T)      728 (T)      ---          ---       |   630          ---          728 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.161N     P=0.428N     P=0.215N     P=0.209N   |  P=0.226N     P=0.281N     P=0.541N     P=0.217N   |
|INCIDENTAL TUMOR       |  P=0.161N     P=0.428N     P=0.215N     P=0.209N   |  P=0.261N     P=0.406N     P=0.533N     P=0.329N   |
|LOGISTIC REGRESSION    |  P=0.161N     P=0.428N     P=0.215N     P=0.209N   |  P=0.255N     P=0.242N     P=0.507N     P=0.234N   |
|COCHRAN-ARMITAGE       |  P=0.169N                                          |  P=0.266N                                          |
|FISHER EXACT           |               P=0.506N     P=0.256N     P=0.248N   |               P=0.248N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   5
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    2/60 (3%)    1/59 (2%)    0/60 (0%)  |  1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.5%         4.3%         2.6%         0.0%      |   2.5%         3.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/35 (3%)    1/43 (2%)    1/39 (3%)    0/40 (0%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   722          582          728 (T)      ---       |   722          710          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.139N     P=0.641N     P=0.466N     P=0.217N   |  P=0.265N     P=0.690      P=0.532N     P=0.477N   |
|INCIDENTAL TUMOR       |  P=0.124N     P=0.565N     P=0.525N     P=0.311N   |  P=0.562N     P=0.487N     P=0.419N     P=0.718N   |
|LOGISTIC REGRESSION    |  P=0.146N     P=0.693N     P=0.485N     P=0.237N   |  P=0.289N     P=0.744      P=0.514N     P=0.485N   |
|COCHRAN-ARMITAGE       |  P=0.143N                                          |  P=0.306N                                          |
|FISHER EXACT           |               P=0.691N     P=0.506N     P=0.248N   |               P=0.752N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    3/60 (5%)   17/59 (29%)   9/60 (15%) |  1/60 (2%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         6.4%        37.1%        21.3%      |   2.6%         3.3%         5.1%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    1/43 (2%)   11/39 (28%)   7/40 (18%) |  1/38 (3%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          582          617          709       |   728 (T)      711          664          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.019 *    P=0.143      P<0.001 **   P=0.005 ** |  P=0.278N     P=0.684      P=0.469      P=0.466N   |
|INCIDENTAL TUMOR       |  P=0.012 *    P=0.151      P<0.001 **   P=0.002 ** |  P=0.573N     P=0.696N     P=0.578      P=0.466N   |
|LOGISTIC REGRESSION    |  P=0.011 *    P=0.121      P<0.001 **   P=0.002 ** |  P=0.314N     P=0.740      P=0.491      P=0.466N   |
|COCHRAN-ARMITAGE       |  P=0.016 *                                         |  P=0.332N                                          |
|FISHER EXACT           |               P=0.122      P<0.001 **   P=0.001 ** |               P=0.752N     P=0.500      P=0.500N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   6
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/60 (27%)  26/60 (43%)  41/59 (69%)  30/60 (50%) | 14/60 (23%)  21/60 (35%)  38/60 (63%)  18/60 (30%) |
|ADJUSTED (b)           |  38.5%        56.3%        89.0%        65.0%      |  36.8%        61.7%        84.1%        39.1%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   0/10 (0%)    0/9 (0%)     1/10 (10%) |  0/10 (0%)    1/10 (10%)   2/10 (20%)   0/10 (0%)  |
|TERMINAL (d)           | 11/35 (31%)  23/43 (53%)  34/39 (87%)  24/40 (60%) | 14/38 (37%)  14/26 (54%)  26/33 (79%)  17/45 (38%) |
|FIRST INCIDENCE (DAYS) |   455 (I)      549          617          455 (I)   |   728 (T)      456 (I)      455 (I)      710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.050      P=0.156      P<0.001 **   P=0.025 *  |  P=0.108N     P=0.007 **   P<0.001 **   P=0.473    |
|INCIDENTAL TUMOR       |  P=0.017 *    P=0.081      P<0.001 **   P=0.003 ** |  P=0.373N     P=0.021 *    P<0.001 **   P=0.422    |
|LOGISTIC REGRESSION    |  P=0.015 *    P=0.042 *    P<0.001 **   P=0.004 ** |  P=0.413N     P=0.066      P<0.001 **   P=0.412    |
|COCHRAN-ARMITAGE       |  P=0.036 *                                         |  P=0.527                                           |
|FISHER EXACT           |               P=0.042 *    P<0.001 **   P=0.007 ** |               P=0.114      P<0.001 **   P=0.268    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)  13/60 (22%)  11/59 (19%)   7/60 (12%) |  5/60 (8%)    2/60 (3%)    8/60 (13%)   3/60 (5%)  |
|ADJUSTED (b)           |  16.3%        27.2%        25.5%        16.7%      |  12.6%         5.1%        21.8%         6.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/35 (9%)    9/43 (21%)   8/39 (21%)   5/40 (13%) |  4/38 (11%)   0/26 (0%)    5/33 (15%)   3/45 (7%)  |
|FIRST INCIDENCE (DAYS) |   647          455 (I)      626          710       |   693          619          686          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.272N     P=0.202      P=0.271      P=0.558N   |  P=0.260N     P=0.336N     P=0.208      P=0.274N   |
|INCIDENTAL TUMOR       |  P=0.372N     P=0.033 *    P=0.234      P=0.397    |  P=0.499N     P=0.229N     P=0.290      P=0.342N   |
|LOGISTIC REGRESSION    |  P=0.301N     P=0.114      P=0.224      P=0.598    |  P=0.361N     P=0.238N     P=0.236      P=0.312N   |
|COCHRAN-ARMITAGE       |  P=0.280N                                          |  P=0.430N                                          |
|FISHER EXACT           |               P=0.110      P=0.210      P=0.611N   |               P=0.219N     P=0.279      P=0.359N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   7
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)  15/60 (25%)  23/59 (39%)  15/60 (25%) |  6/60 (10%)   3/60 (5%)    9/60 (15%)   3/60 (5%)  |
|ADJUSTED (b)           |  16.3%        30.3%        48.4%        34.9%      |  15.2%         8.3%        23.7%         6.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/35 (9%)    9/43 (21%)  15/39 (38%)  12/40 (30%) |  5/38 (13%)   0/26 (0%)    5/33 (15%)   3/45 (7%)  |
|FIRST INCIDENCE (DAYS) |   647          455 (I)      617          709       |   693          619          664          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.211      P=0.110      P=0.003 **   P=0.082    |  P=0.158N     P=0.397N     P=0.217      P=0.172N   |
|INCIDENTAL TUMOR       |  P=0.105      P=0.013 *    P<0.001 **   P=0.014 *  |  P=0.406N     P=0.216N     P=0.312      P=0.221N   |
|LOGISTIC REGRESSION    |  P=0.144      P=0.027 *    P<0.001 **   P=0.040 *  |  P=0.236N     P=0.272N     P=0.249      P=0.202N   |
|COCHRAN-ARMITAGE       |  P=0.186                                           |  P=0.295N                                          |
|FISHER EXACT           |               P=0.049 *    P<0.001 **   P=0.049 *  |               P=0.245N     P=0.291      P=0.245N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/60 (38%)  33/60 (55%)  45/59 (76%)  33/60 (55%) | 17/60 (28%)  22/60 (37%)  39/60 (65%)  20/60 (33%) |
|ADJUSTED (b)           |  50.8%        65.9%        91.8%        71.6%      |  43.5%        62.9%        86.4%        43.5%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   1/10 (10%)   0/9 (0%)     1/10 (10%) |  0/10 (0%)    1/10 (10%)   2/10 (20%)   0/10 (0%)  |
|TERMINAL (d)           | 14/35 (40%)  26/43 (60%)  35/39 (90%)  27/40 (68%) | 16/38 (42%)  14/26 (54%)  27/33 (82%)  19/45 (42%) |
|FIRST INCIDENCE (DAYS) |   455 (I)      455 (I)      617          455 (I)   |   693          456 (I)      455 (I)      710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.223      P=0.227      P<0.001 **   P=0.135    |  P=0.088N     P=0.020 *    P<0.001 **   P=0.577N   |
|INCIDENTAL TUMOR       |  P=0.073      P=0.030 *    P<0.001 **   P=0.014 *  |  P=0.370N     P=0.080      P<0.001 **   P=0.496    |
|LOGISTIC REGRESSION    |  P=0.092      P=0.048 *    P<0.001 **   P=0.030 *  |  P=0.388N     P=0.140      P<0.001 **   P=0.489    |
|COCHRAN-ARMITAGE       |  P=0.163                                           |  P=0.537                                           |
|FISHER EXACT           |               P=0.050 *    P<0.001 **   P=0.050 *  |               P=0.218      P<0.001 **   P=0.346    |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   8
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/60 (38%)  34/60 (57%)  46/59 (78%)  35/60 (58%) | 17/60 (28%)  23/60 (38%)  39/60 (65%)  20/60 (33%) |
|ADJUSTED (b)           |  50.8%        66.6%        93.8%        75.9%      |  43.5%        64.1%        86.4%        43.5%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   1/10 (10%)   0/9 (0%)     1/10 (10%) |  0/10 (0%)    1/10 (10%)   2/10 (20%)   0/10 (0%)  |
|TERMINAL (d)           | 14/35 (40%)  26/43 (60%)  36/39 (92%)  29/40 (73%) | 16/38 (42%)  14/26 (54%)  27/33 (82%)  19/45 (42%) |
|FIRST INCIDENCE (DAYS) |   455 (I)      455 (I)      617          455 (I)   |   693          456 (I)      455 (I)      710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.142      P=0.182      P<0.001 **   P=0.076    |  P=0.076N     P=0.012 *    P<0.001 **   P=0.577N   |
|INCIDENTAL TUMOR       |  P=0.036 *    P=0.030 *    P<0.001 **   P=0.005 ** |  P=0.358N     P=0.067      P<0.001 **   P=0.496    |
|LOGISTIC REGRESSION    |  P=0.041 *    P=0.020 *    P<0.001 **   P=0.011 *  |  P=0.353N     P=0.099      P<0.001 **   P=0.489    |
|COCHRAN-ARMITAGE       |  P=0.093                                           |  P=0.519N                                          |
|FISHER EXACT           |               P=0.034 *    P<0.001 **   P=0.022 *  |               P=0.166      P<0.001 **   P=0.346    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)   13/60 (22%)   4/59 (7%)    3/60 (5%)  |  5/60 (8%)    2/60 (3%)    4/60 (7%)    0/60 (0%)  |
|ADJUSTED (b)           |  14.3%        25.1%         9.0%         7.5%      |  11.7%         6.3%         9.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    3/10 (30%)   0/9 (0%)     0/10 (0%)  |  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  5/35 (14%)   6/43 (14%)   2/39 (5%)    3/40 (8%)  |  3/38 (8%)    1/26 (4%)    2/33 (6%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   728 (T)      455 (I)      617          728 (T)   |   456 (I)      691          445          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.055N     P=0.076      P=0.447N     P=0.284N   |  P=0.032N*    P=0.330N     P=0.550N     P=0.026N*  |
|INCIDENTAL TUMOR       |  P=0.052N     P=0.048 *    P=0.334N     P=0.284N   |  P=0.043N*    P=0.176N     P=0.428N     P=0.041N*  |
|LOGISTIC REGRESSION    |  P=0.058N     P=0.037 *    P=0.494N     P=0.284N   |  P=0.050N*    P=0.225N     P=0.504N     P=0.033N*  |
|COCHRAN-ARMITAGE       |  P=0.056N                                          |  P=0.049N*                                         |
|FISHER EXACT           |               P=0.036 *    P=0.511N     P=0.359N   |               P=0.219N     P=0.500N     P=0.029N*  |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE   9
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    0/59 (0%)    1/60 (2%)  |  2/60 (3%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.1%         6.3%         0.0%         2.5%      |   5.3%         2.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    1/43 (2%)    0/39 (0%)    1/40 (3%)  |  2/38 (5%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   652          457 (I)      ---          728 (T)   |   728 (T)      648          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.434N     P=0.337      P=0.500N     P=0.750N   |  P=0.142N     P=0.587N     P=0.270N     P=0.202N   |
|INCIDENTAL TUMOR       |  P=0.503N     P=0.160      P=0.588N     P=0.689    |  P=0.177N     P=0.464N     P=0.270N     P=0.202N   |
|LOGISTIC REGRESSION    |  P=0.427N     P=0.302      P=0.507N     P=0.759    |  P=0.161N     P=0.517N     P=0.270N     P=0.202N   |
|COCHRAN-ARMITAGE       |  P=0.436N                                          |  P=0.169N                                          |
|FISHER EXACT           |               P=0.309      P=0.504N     P=0.752N   |               P=0.500N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)  16/60 (27%)   4/59 (7%)    4/60 (7%)  |  7/60 (12%)   3/60 (5%)    4/60 (7%)    0/60 (0%)  |
|ADJUSTED (b)           |  16.1%        30.2%         9.0%        10.0%      |  16.7%         8.4%         9.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    4/10 (40%)   0/9 (0%)     0/10 (0%)  |  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  5/35 (14%)   7/43 (16%)   2/39 (5%)    4/40 (10%) |  5/38 (13%)   1/26 (4%)    2/33 (6%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   652          455 (I)      617          728 (T)   |   456 (I)      648          445          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.045N*    P=0.043 *    P=0.325N     P=0.299N   |  P=0.009N**   P=0.282N     P=0.321N     P=0.006N** |
|INCIDENTAL TUMOR       |  P=0.048N*    P=0.012 *    P=0.249N     P=0.343N   |  P=0.013N*    P=0.117N     P=0.224N     P=0.010N** |
|LOGISTIC REGRESSION    |  P=0.045N*    P=0.017 *    P=0.367N     P=0.380N   |  P=0.015N*    P=0.170N     P=0.264N     P=0.009N** |
|COCHRAN-ARMITAGE       |  P=0.044N*                                         |  P=0.015N*                                         |
|FISHER EXACT           |               P=0.016 *    P=0.382N     P=0.372N   |               P=0.161N     P=0.264N     P=0.006N** |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  10
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/59 (3%)    1/60 (2%)    0/58 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |                                                    |   4.4%         3.8%         0.0%         2.2%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/37 (3%)    1/26 (4%)    0/32 (0%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   455 (I)      728 (T)      ---          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.417N     P=0.581N     P=0.256N     P=0.455N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.417N     P=0.581N     P=0.256N     P=0.455N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.494N     P=0.493N     P=0.249N     P=0.505N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.496N                                          |
|FISHER EXACT           |                                                    |               P=0.494N     P=0.252N     P=0.494N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/57 (0%)    1/56 (2%)    0/58 (0%)    0/58 (0%)  |  8/59 (14%)   6/57 (11%)   8/58 (14%)   0/58 (0%)  |
|ADJUSTED (b)           |   0.0%         2.2%         0.0%         0.0%      |  20.5%        21.7%        22.9%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    0/40 (0%)    0/38 (0%)    0/39 (0%)  |  7/37 (19%)   4/24 (17%)   6/32 (19%)   0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          710          ---          ---       |   457 (I)      704          546          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.589N     P=0.523        (e)          (e)      |  P=0.002N**   P=0.549      P=0.496      P=0.003N** |
|INCIDENTAL TUMOR       |  P=0.676N     P=0.295        (e)          (e)      |  P=0.003N**   P=0.541N     P=0.594      P=0.003N** |
|LOGISTIC REGRESSION    |  P=0.583N     P=0.502        (e)          (e)      |  P=0.005N**   P=0.466N     P=0.570      P=0.005N** |
|COCHRAN-ARMITAGE       |  P=0.581N                                          |  P=0.007N**                                        |
|FISHER EXACT           |               P=0.496        (e)          (e)      |               P=0.415N     P=0.591      P=0.003N** |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  11
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/57 (0%)    1/56 (2%)    0/58 (0%)    0/58 (0%)  |  8/59 (14%)   6/57 (11%)   9/58 (16%)   0/58 (0%)  |
|ADJUSTED (b)           |   0.0%         2.2%         0.0%         0.0%      |  20.5%        21.7%        24.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  1/10 (10%)   0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    0/40 (0%)    0/38 (0%)    0/39 (0%)  |  7/37 (19%)   4/24 (17%)   6/32 (19%)   0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          710          ---          ---       |   457 (I)      704          456 (I)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.589N     P=0.523        (e)          (e)      |  P=0.002N**   P=0.549      P=0.393      P=0.003N** |
|INCIDENTAL TUMOR       |  P=0.676N     P=0.295        (e)          (e)      |  P=0.004N**   P=0.541N     P=0.486      P=0.003N** |
|LOGISTIC REGRESSION    |  P=0.583N     P=0.502        (e)          (e)      |  P=0.006N**   P=0.466N     P=0.474      P=0.005N** |
|COCHRAN-ARMITAGE       |  P=0.581N                                          |  P=0.008N**                                        |
|FISHER EXACT           |               P=0.496        (e)          (e)      |               P=0.415N     P=0.485      P=0.003N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/57 (0%)    1/56 (2%)    0/58 (0%)    0/58 (0%)  |  1/59 (2%)    1/57 (2%)    3/58 (5%)    0/58 (0%)  |
|ADJUSTED (b)           |   0.0%         2.5%         0.0%         0.0%      |   2.7%         4.2%         9.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    1/40 (3%)    0/38 (0%)    0/39 (0%)  |  1/37 (3%)    1/24 (4%)    3/32 (9%)    0/43 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          728 (T)      ---          ---       |   728 (T)      728 (T)      728 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.569N     P=0.545        (e)          (e)      |  P=0.247N     P=0.662      P=0.254      P=0.470N   |
|INCIDENTAL TUMOR       |  P=0.569N     P=0.545        (e)          (e)      |  P=0.247N     P=0.662      P=0.254      P=0.470N   |
|LOGISTIC REGRESSION    |  P=0.569N     P=0.545        (e)          (e)      |  P=0.247N     P=0.662      P=0.254      P=0.470N   |
|COCHRAN-ARMITAGE       |  P=0.581N                                          |  P=0.338N                                          |
|FISHER EXACT           |               P=0.496        (e)          (e)      |               P=0.743      P=0.303      P=0.504N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  12
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    0/58 (0%)    0/58 (0%)  |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.9%         0.0%         0.0%         0.0%      |   0.0%         5.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/35 (3%)    0/43 (0%)    0/38 (0%)    0/38 (0%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   728 (T)      ---          ---          ---       |   ---          676          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.472N     P=0.459N     P=0.484N     P=0.484N   |  P=0.348N     P=0.216        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.472N     P=0.459N     P=0.484N     P=0.484N   |  P=0.695N     P=0.513        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.472N     P=0.459N     P=0.484N     P=0.484N   |  P=0.370N     P=0.230        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.477N                                          |  P=0.380N                                          |
|FISHER EXACT           |               P=0.500N     P=0.508N     P=0.508N   |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    0/60 (0%)    2/59 (3%)    1/60 (2%)  |  3/60 (5%)    1/60 (2%)    6/60 (10%)   2/60 (3%)  |
|ADJUSTED (b)           |   8.0%         0.0%         4.7%         2.5%      |   7.5%         3.8%        16.2%         4.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/35 (6%)    0/43 (0%)    1/39 (3%)    1/40 (3%)  |  2/38 (5%)    1/26 (4%)    4/33 (12%)   2/45 (4%)  |
|FIRST INCIDENCE (DAYS) |   710          ---          708          728 (T)   |   705          728 (T)      546          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.422N     P=0.094N     P=0.471N     P=0.270N   |  P=0.377N     P=0.432N     P=0.194      P=0.429N   |
|INCIDENTAL TUMOR       |  P=0.485N     P=0.147N     P=0.550N     P=0.340N   |  P=0.478N     P=0.305N     P=0.315      P=0.530N   |
|LOGISTIC REGRESSION    |  P=0.441N     P=0.114N     P=0.493N     P=0.308N   |  P=0.486N     P=0.354N     P=0.229      P=0.463N   |
|COCHRAN-ARMITAGE       |  P=0.429N                                          |  P=0.534N                                          |
|FISHER EXACT           |               P=0.122N     P=0.508N     P=0.309N   |               P=0.309N     P=0.245      P=0.500N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  13
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/59 (0%)    2/60 (3%)  |                                                    |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         4.2%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     1/10 (10%) |                                                    |
|TERMINAL (d)           |  0/35 (0%)    0/43 (0%)    0/39 (0%)    1/40 (3%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          455 (I)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.045 *      (e)          (e)        P=0.254    |                                                    |
|INCIDENTAL TUMOR       |  P=0.045 *      (e)          (e)        P=0.254    |                                                    |
|LOGISTIC REGRESSION    |  P=0.054        (e)          (e)        P=0.258    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.042 *                                         |                                                    |
|FISHER EXACT           |                 (e)          (e)        P=0.248    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    2/59 (3%)    0/59 (0%)    0/60 (0%)  |  1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.7%         4.7%         0.0%         0.0%      |   2.6%         3.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/35 (6%)    2/43 (5%)    0/39 (0%)    0/40 (0%)  |  1/38 (3%)    1/26 (4%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   728 (T)      728 (T)      ---          ---       |   728 (T)      728 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.116N     P=0.619N     P=0.215N     P=0.209N   |  P=0.256N     P=0.675      P=0.528N     P=0.466N   |
|INCIDENTAL TUMOR       |  P=0.116N     P=0.619N     P=0.215N     P=0.209N   |  P=0.256N     P=0.675      P=0.528N     P=0.466N   |
|LOGISTIC REGRESSION    |  P=0.116N     P=0.619N     P=0.215N     P=0.209N   |  P=0.256N     P=0.675      P=0.528N     P=0.466N   |
|COCHRAN-ARMITAGE       |  P=0.122N                                          |  P=0.306N                                          |
|FISHER EXACT           |               P=0.691N     P=0.248N     P=0.244N   |               P=0.752N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  14
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  3/60 (5%)    5/60 (8%)    4/60 (7%)    2/60 (3%)  |
|ADJUSTED (b)           |                                                    |   7.9%        16.3%        12.1%         4.4%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  3/38 (8%)    2/26 (8%)    4/33 (12%)   2/45 (4%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   728 (T)      695          728 (T)      728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.154N     P=0.197      P=0.423      P=0.423N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.250N     P=0.441      P=0.423      P=0.423N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.206N     P=0.296      P=0.423      P=0.423N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.277N                                          |
|FISHER EXACT           |                                                    |               P=0.359      P=0.500      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/60 (0%)    2/60 (3%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |                                                    |   0.0%         5.4%         0.0%         2.2%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/38 (0%)    0/26 (0%)    0/33 (0%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          455 (I)      ---          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.662      P=0.197        (e)        P=0.534    |
|INCIDENTAL TUMOR       |                                                    |  P=0.555      P=0.358        (e)        P=0.534    |
|LOGISTIC REGRESSION    |                                                    |  P=0.607      P=0.237        (e)        P=0.534    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.615                                           |
|FISHER EXACT           |                                                    |               P=0.248        (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  15
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  3/60 (5%)    6/60 (10%)   4/60 (7%)    3/60 (5%)  |
|ADJUSTED (b)           |                                                    |   7.9%        17.8%        12.1%         6.7%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  3/38 (8%)    2/26 (8%)    4/33 (12%)   3/45 (7%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   728 (T)      455 (I)      728 (T)      728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.227N     P=0.126      P=0.423      P=0.583N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.344N     P=0.308      P=0.423      P=0.583N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.335N     P=0.228      P=0.423      P=0.583N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.383N                                          |
|FISHER EXACT           |                                                    |               P=0.245      P=0.500      P=0.660N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    0/59 (0%)    0/60 (0%)  |  2/60 (3%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   2.2%         2.3%         0.0%         0.0%      |   5.3%         2.7%         0.0%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    1/43 (2%)    0/39 (0%)    0/40 (0%)  |  2/38 (5%)    0/26 (0%)    0/33 (0%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   709          728 (T)      ---          ---       |   728 (T)      700          ---          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.308N     P=0.730N     P=0.509N     P=0.509N   |  P=0.409N     P=0.602N     P=0.270N     P=0.441N   |
|INCIDENTAL TUMOR       |  P=0.349N     P=0.682      P=0.588N     P=0.669N   |  P=0.501N     P=0.464N     P=0.270N     P=0.441N   |
|LOGISTIC REGRESSION    |  P=0.310N     P=0.757N     P=0.499N     P=0.504N   |  P=0.458N     P=0.536N     P=0.270N     P=0.441N   |
|COCHRAN-ARMITAGE       |  P=0.306N                                          |  P=0.500N                                          |
|FISHER EXACT           |               P=0.752N     P=0.504N     P=0.500N   |               P=0.500N     P=0.248N     P=0.500N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  16
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    2/60 (3%)    1/59 (2%)    3/60 (5%)  |  1/60 (2%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   8.3%         4.3%         2.6%         6.2%      |   2.5%         5.3%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/35 (6%)    1/43 (2%)    1/39 (3%)    1/40 (3%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   722          582          728 (T)      455 (I)   |   722          676          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.518      P=0.431N     P=0.272N     P=0.626N   |  P=0.185N     P=0.426      P=0.532N     P=0.477N   |
|INCIDENTAL TUMOR       |  P=0.579      P=0.332N     P=0.315N     P=0.537N   |  P=0.461N     P=0.622N     P=0.419N     P=0.718N   |
|LOGISTIC REGRESSION    |  P=0.518      P=0.496N     P=0.285N     P=0.662N   |  P=0.204N     P=0.483      P=0.514N     P=0.485N   |
|COCHRAN-ARMITAGE       |  P=0.510                                           |  P=0.215N                                          |
|FISHER EXACT           |               P=0.500N     P=0.316N     P=0.660N   |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    3/60 (5%)    1/59 (2%)    3/60 (5%)  |  3/60 (5%)    3/60 (5%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  10.3%         6.6%         2.6%         6.2%      |   7.6%         7.9%         0.0%         2.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/35 (6%)    2/43 (5%)    1/39 (3%)    1/40 (3%)  |  2/38 (5%)    0/26 (0%)    0/33 (0%)    1/45 (2%)  |
|FIRST INCIDENCE (DAYS) |   709          582          728 (T)      455 (I)   |   722          676          ---          728 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.502N     P=0.421N     P=0.163N     P=0.470N   |  P=0.143N     P=0.540      P=0.150N     P=0.253N   |
|INCIDENTAL TUMOR       |  P=0.469N     P=0.420N     P=0.213N     P=0.432N   |  P=0.330N     P=0.369N     P=0.114N     P=0.347N   |
|LOGISTIC REGRESSION    |  P=0.505N     P=0.494N     P=0.173N     P=0.502N   |  P=0.173N     P=0.633      P=0.136N     P=0.268N   |
|COCHRAN-ARMITAGE       |  P=0.508N                                          |  P=0.197N                                          |
|FISHER EXACT           |               P=0.500N     P=0.187N     P=0.500N   |               P=0.660N     P=0.122N     P=0.309N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  17
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/59 (2%)    1/60 (2%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.5%         2.5%      |   5.0%         0.0%         3.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    0/43 (0%)    0/39 (0%)    1/40 (3%)  |  0/38 (0%)    0/26 (0%)    1/33 (3%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          722          728 (T)   |   722          ---          728 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.312        (e)        P=0.516      P=0.527    |  P=0.215N     P=0.337N     P=0.554N     P=0.213N   |
|INCIDENTAL TUMOR       |  P=0.253        (e)        P=0.412      P=0.527    |  P=0.392N     P=0.042N*    P=0.422N     P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.299        (e)        P=0.504      P=0.527    |  P=0.236N     P=0.265N     P=0.527N     P=0.220N   |
|COCHRAN-ARMITAGE       |  P=0.306                                           |  P=0.266N                                          |
|FISHER EXACT           |                 (e)        P=0.496      P=0.500    |               P=0.248N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    7/60 (12%)   5/59 (8%)    9/60 (15%) |  7/60 (12%)  14/60 (23%)  15/60 (25%)   5/60 (8%)  |
|ADJUSTED (b)           |  10.2%        15.4%        11.3%        19.6%      |  17.1%        41.3%        38.2%        10.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/9 (11%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/35 (6%)    5/43 (12%)   2/39 (5%)    4/40 (10%) |  4/38 (11%)   8/26 (31%)  10/33 (30%)   4/45 (9%)  |
|FIRST INCIDENCE (DAYS) |   703          709          457 (I)      576       |   708          646          539          710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.140      P=0.366      P=0.529      P=0.154    |  P=0.028N*    P=0.017 *    P=0.029 *    P=0.281N   |
|INCIDENTAL TUMOR       |  P=0.063      P=0.144      P=0.402      P=0.050    |  P=0.155N     P=0.169      P=0.067      P=0.543N   |
|LOGISTIC REGRESSION    |  P=0.114      P=0.279      P=0.496      P=0.111    |  P=0.123N     P=0.045 *    P=0.037 *    P=0.322N   |
|COCHRAN-ARMITAGE       |  P=0.129                                           |  P=0.099N                                          |
|FISHER EXACT           |               P=0.264      P=0.489      P=0.120    |               P=0.074      P=0.049 *    P=0.381N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  18
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    7/60 (12%)   5/59 (8%)    8/60 (13%) |  5/60 (8%)   14/60 (23%)  14/60 (23%)   5/60 (8%)  |
|ADJUSTED (b)           |  10.2%        15.4%        11.3%        17.3%      |  12.7%        41.3%        35.5%        10.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/9 (11%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/35 (6%)    5/43 (12%)   2/39 (5%)    3/40 (8%)  |  4/38 (11%)   8/26 (31%)   9/33 (27%)   4/45 (9%)  |
|FIRST INCIDENCE (DAYS) |   703          709          457 (I)      576       |   708          646          539          710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.223      P=0.366      P=0.529      P=0.216    |  P=0.054N     P=0.004 **   P=0.013 *    P=0.523N   |
|INCIDENTAL TUMOR       |  P=0.116      P=0.144      P=0.402      P=0.081    |  P=0.212N     P=0.035 *    P=0.028 *    P=0.591    |
|LOGISTIC REGRESSION    |  P=0.195      P=0.279      P=0.496      P=0.170    |  P=0.209N     P=0.012 *    P=0.017 *    P=0.577N   |
|COCHRAN-ARMITAGE       |  P=0.212                                           |  P=0.162N                                          |
|FISHER EXACT           |               P=0.264      P=0.489      P=0.181    |               P=0.022 *    P=0.022 *    P=0.628N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |  2/60 (3%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.1%         2.5%         2.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    0/43 (0%)    0/39 (0%)    0/40 (0%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   312          682          564          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.179N     P=0.528N     P=0.515N     P=0.223N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.556N     P=0.251N     P=0.716N     P=0.718N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.220N     P=0.502N     P=0.559N     P=0.292N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.193N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  19
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |  2/60 (3%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.1%         2.5%         2.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/35 (0%)    0/43 (0%)    0/39 (0%)    0/40 (0%)  |  0/38 (0%)    0/26 (0%)    0/33 (0%)    0/45 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   312          682          564          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.179N     P=0.528N     P=0.515N     P=0.223N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.556N     P=0.251N     P=0.716N     P=0.718N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.220N     P=0.502N     P=0.559N     P=0.292N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.193N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 31/60 (52%)  40/60 (67%)  45/59 (76%)  32/60 (53%) | 34/60 (57%)  32/60 (53%)  46/60 (77%)  22/60 (37%) |
|ADJUSTED (b)           |  69.7%        75.3%        95.7%        69.4%      |  74.9%        81.3%        95.8%        47.8%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   3/10 (30%)   0/9 (0%)     1/10 (10%) |  3/10 (30%)   1/10 (10%)   3/10 (30%)   0/10 (0%)  |
|TERMINAL (d)           | 22/35 (63%)  30/43 (70%)  37/39 (95%)  26/40 (65%) | 27/38 (71%)  19/26 (73%)  31/33 (94%)  21/45 (47%) |
|FIRST INCIDENCE (DAYS) |   455 (I)      455 (I)      617          455 (I)   |   312          456 (I)      445          710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.226N     P=0.359      P=0.032 *    P=0.420N   |  P<0.001N**   P=0.118      P=0.003 **   P=0.002N** |
|INCIDENTAL TUMOR       |  P=0.363N     P=0.102      P=0.003 **   P=0.373    |  P=0.001N**   P=0.511      P=0.003 **   P=0.008N** |
|LOGISTIC REGRESSION    |  P=0.349N     P=0.065      P=0.002 **   P=0.440    |  P=0.001N**   P=0.497N     P=0.004 **   P=0.010N** |
|COCHRAN-ARMITAGE       |  P=0.282N                                          |  P=0.008N**                                        |
|FISHER EXACT           |               P=0.068      P=0.004 **   P=0.500    |               P=0.427N     P=0.016 *    P=0.022N*  |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  20
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0.0%         0.0666%      0.200%       0.600%    |   0.0%         0.0666%      0.200%       0.600%    |
|                       |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |   15 SSAC      15 SSAC      15 SSAC      15 SSAC   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/60 (27%)  25/60 (42%)  28/59 (47%)  27/60 (45%) | 21/60 (35%)  28/60 (47%)  25/60 (42%)  10/60 (17%) |
|ADJUSTED (b)           |  36.0%        47.9%        56.8%        53.9%      |  45.9%        58.5%        56.0%        21.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    2/10 (20%)   1/9 (11%)    1/10 (10%) |  1/10 (10%)   1/10 (10%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  8/35 (23%)  16/43 (37%)  18/39 (46%)  17/40 (43%) | 14/38 (37%)   8/26 (31%)  14/33 (42%)   9/45 (20%) |
|FIRST INCIDENCE (DAYS) |   647          455 (I)      457 (I)      455 (I)   |   312          331          456 (I)      710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120      P=0.190      P=0.051      P=0.075    |  P<0.001N**   P=0.034 *    P=0.175      P=0.007N** |
|INCIDENTAL TUMOR       |  P=0.033 *    P=0.019 *    P=0.012 *    P=0.006 ** |  P=0.019N*    P=0.424      P=0.265      P=0.038N*  |
|LOGISTIC REGRESSION    |  P=0.033 *    P=0.017 *    P=0.010 **   P=0.006 ** |  P<0.001N**   P=0.122      P=0.269      P=0.013N*  |
|COCHRAN-ARMITAGE       |  P=0.082                                           |  P=0.001N**                                        |
|FISHER EXACT           |               P=0.062      P=0.015 *    P=0.028 *  |               P=0.133      P=0.287      P=0.018N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/60 (67%)  45/60 (75%)  50/59 (85%)  43/60 (72%) | 43/60 (72%)  46/60 (77%)  51/60 (85%)  28/60 (47%) |
|ADJUSTED (b)           |  79.8%        83.2%        98.0%        84.2%      |  85.8%        91.8%       100.0%        60.9%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   4/10 (40%)   1/9 (11%)    2/10 (20%) |  4/10 (40%)   2/10 (20%)   4/10 (40%)   0/10 (0%)  |
|TERMINAL (d)           | 25/35 (71%)  34/43 (79%)  38/39 (97%)  32/40 (80%) | 31/38 (82%)  22/26 (85%)  33/33 (100%) 27/45 (60%) |
|FIRST INCIDENCE (DAYS) |   455 (I)      455 (I)      457 (I)      455 (I)   |   312          331          445          710       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.506N     P=0.452N     P=0.169      P=0.521N   |  P<0.001N**   P=0.017 *    P=0.017 *    P<0.001N** |
|INCIDENTAL TUMOR       |  P=0.336      P=0.156      P=0.009 **   P=0.192    |  P<0.001N**   P=0.392      P=0.023 *    P=0.002N** |
|LOGISTIC REGRESSION    |  P=0.333      P=0.207      P=0.010 **   P=0.194    |  P<0.001N**   P=0.277      P=0.042 *    P=0.001N** |
|COCHRAN-ARMITAGE       |  P=0.495                                           |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.211      P=0.018 *    P=0.346    |               P=0.339      P=0.060      P=0.004N** |
|=================================================================================================================================|
         DATE: 09/12/94                     EXPERIMENT: 05092 TEST: 02                                                 PAGE  21
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-NITROANISOLE
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   455
          Female interim sacrifices(days): 455
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).