TDMS Study 05092-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/12/94
EXP: 05092 O-NITROANISOLE TIME: 19:33:08
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60388B
CONT: N01-ES-45038 CAS: 0091-23-6
PATHOLOGIST: J. HEATH S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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TREATMENT GROUPS:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/12/94
EXP: 05092 O-NITROANISOLE TIME: 19:33:08
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60388B
CONT: N01-ES-45038 CAS: 0091-23-6
PATHOLOGIST: J. HEATH S. EUSTIS
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 479 647 652 703 708 709 709 709 709 710 |
| 711 711 715 722 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 456 456 456 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0666% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 549 582 709 709 710 710 710 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0666% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 455 456 456 456 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.200% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 617 626 672 707 708 708 708 709 709 711 |
| 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.200% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 9 UNCENSORED DEATHS 0 CENSORED DEATHS 9 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 456 456 457 457 457 457 |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.600% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 98 466 576 627 673 708 708 709 710 711 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.600% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 455 456 456 456 457 457 457 |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 98.0 94.0 70.0 |
| | |
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
|0.0666% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 86.0 |
| | |
| | |
|0.0666% | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
|0.200% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 78.0 |
| | |
| | |
|0.200% | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
|0.600% | 100.0 98.0 98.0 98.0 98.0 96.0 96.0 94.0 92.0 80.0 |
| | |
| | |
|0.600% | 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200% 0.600% 0.600% |
| 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 0.0% 86.0% 0.0% 78.0% 0.0% 80.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.836N ----- P=0.095N ----- P=0.543N ----- P=0.435N ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 687.7 . 668.4 . 690.6 . 598.6 . |
|NATURAL DEATHS (C) | (16.0) ( . ) (26.8) ( . ) (11.0) ( . ) (61.1) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 715.9 456.1 719.7 455.9 719.8 456.1 702.1 455.9 |
|(STANDARD ERROR) | ( 5.4) ( 0.3) ( 4.6) ( 0.3) ( 3.2) ( 0.3) (13.9) ( 0.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 137 312 525 564 627 630 648 693 705 708 |
| 722 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 456 456 456 456 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0666% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 331 353 392 425 619 646 648 674 676 679 |
| 682 691 695 700 700 704 708 710 710 710 |
| 711 711 711 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0666% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 455 456 456 456 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.200% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 445 539 539 539 546 564 592 603 664 686 |
| 700 702 704 708 711 721 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.200% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 456 456 456 456 457 457 457 |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.600% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 401 452 597 710 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.600% 15 SSAC |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 0 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 455 455 455 456 456 456 456 457 457 457 |
| |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 98.0 98.0 96.0 96.0 96.0 94.0 92.0 86.0 76.0 |
| | |
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
|0.0666% | 100.0 100.0 100.0 96.0 92.0 92.0 92.0 92.0 86.0 52.0 |
| | |
| | |
|0.0666% | 100.0 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
|0.200% | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 84.0 82.0 66.0 |
| | |
| | |
|0.200% | 100.0 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
|0.600% | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 94.0 94.0 90.0 |
| | |
| | |
|0.600% | 100.0 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 |
|15 SSAC | |
| | |
==================================================================================
O-NITROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.0% 0.0666% 0.0666% 0.200% 0.200% 0.600% 0.600% |
| 15 SSAC 15 SSAC 15 SSAC 15 SSAC |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 0.0% 52.0% 0.0% 66.0% 0.0% 90.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.005N ----- P=0.028 P=1.000N P=0.369 P=1.000N P=0.109N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 582.8 . 637.5 . 628.5 . 574.0 . |
|NATURAL DEATHS (C) | (52.6) ( . ) (25.1) ( . ) (21.2) ( . ) (64.2) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.1 456.0 684.6 455.9 694.2 456.0 712.6 456.0 |
|(STANDARD ERROR) | (15.1) ( 0.3) (13.6) ( 0.3) ( 9.7) ( 0.3) ( 8.8) ( 0.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.0% 15 SSAC = 2
0.0666% = 3
0.0666% 15 SSAC = 4
0.200% = 5
0.200% 15 SSAC = 6
0.600% = 7
0.600% 15 SSAC = 8
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 7 2 1 3 3 55 1
| 7 73 5 11 5 13
P | 7 7 11
E | 3 3
R 80 + 5 5
C | 111
E | 1
N |
T 60 +
|
S |
U |
R 40 +
V |
I |
V |
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 31 obs hidden.
O-NITROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.0% 15 SSAC = 2
0.0666% = 3
0.0666% 15 SSAC = 4
0.200% = 5
0.200% 15 SSAC = 6
0.600% = 7
0.600% 15 SSAC = 8
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 1 3 3 7 5 7 2 5
| 1 3 3 3 7 1 1 7 7
P | 3 55 1 5 31 1 7 7
E | 5 5 1 5 3 1 1
R 80 + 5 333511 1
C | 3355 1
E | 33355
N | 5
T 60 +
|
S | 3 3
U |
R 40 +
V |
I |
V |
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 38 obs hidden.