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https://ntp.niehs.nih.gov/go/1427

TDMS Study 05092-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           O-NITROANISOLE


NTP Experiment-Test: 05092-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: DOSED FEED                                                                                                 Time: 15:57:55




       Facility:  Southern Research Institute

       Chemical CAS #:  0091-23-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           50           10           50           10           
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17                         7                        18                        
    Natural Death                                                                2                         6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                        41                        26                        
  Animals Examined Microscopically                    50           10           50           10           50           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (10)         (49)                      (46)                      
      Parasite Metazoan                                1 (2%)                    3 (6%)                    2 (4%)                   
   Intestine Large, Colon                             (50)         (10)         (49)                      (46)                      
      Parasite Metazoan                                3 (6%)       2 (20%)      5 (10%)                   1 (2%)                   
   Intestine Large, Rectum                            (50)         (10)         (49)                      (46)                      
      Parasite Metazoan                                3 (6%)                    4 (8%)                    2 (4%)                   
   Intestine Small, Ileum                             (50)         (10)         (49)                      (46)                      
      Hyperplasia, Lymphoid                                                      1 (2%)                    1 (2%)                   
   Liver                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Basophilic Focus                                 2 (4%)       2 (20%)                                4 (8%)       4 (40%)     
      Basophilic Focus, Multiple                      37 (74%)      7 (70%)     41 (82%)      9 (90%)     34 (68%)      5 (50%)     
      Clear Cell Focus                                 5 (10%)                                1 (10%)      3 (6%)                   
      Clear Cell Focus, Multiple                       1 (2%)                    1 (2%)                                             
      Cytomegaly                                       1 (2%)                                                                       
      Degeneration, Multiple                                                                               1 (2%)                   
      Eosinophilic Focus                               3 (6%)                    8 (16%)                   5 (10%)      1 (10%)     
      Eosinophilic Focus, Multiple                     5 (10%)                   2 (4%)                    3 (6%)                   
      Hepatodiaphragmatic Nodule                       4 (8%)                    3 (6%)                   10 (20%)      1 (10%)     
      Hyperplasia, Nodular                             4 (8%)                    1 (2%)                    3 (6%)                   
      Inflammation, Granulomatous, Multiple           36 (72%)      5 (50%)     30 (60%)      5 (50%)     20 (40%)      2 (20%)     
      Karyomegaly                                      1 (2%)                                                                       
      Mixed Cell Focus                                 2 (4%)       1 (10%)      4 (8%)                    2 (4%)       2 (20%)     
      Mixed Cell Focus, Multiple                                                 1 (2%)                                             
      Necrosis                                                                                             2 (4%)                   
      Pigmentation                                                                                         1 (2%)                   
      Vacuolization Cytoplasmic                       10 (20%)                   3 (6%)                    5 (10%)                  
      Bile Duct, Hyperplasia                          29 (58%)      3 (30%)     30 (60%)      1 (10%)     34 (68%)      4 (40%)     
      Centrilobular, Degeneration                      1 (2%)                                                                       
      Serosa, Fibrosis                                                           1 (2%)                                             
      Serosa, Inflammation, Granulomatous                                        1 (2%)                                             
   Mesentery                                          (9)          (1)          (6)          (2)          (11)                      
      Fat, Inflammation, Focal, Granulomatous          2 (22%)                                1 (50%)      1 (9%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Inflammation, Granulomatous                                           1 (17%)                                            
      Fat, Necrosis, Focal                             7 (78%)      1 (100%)     5 (83%)      1 (50%)      9 (82%)                  
      Fat, Necrosis, Focal, Multiple                                                                       1 (9%)                   
   Pancreas                                           (50)         (10)         (50)                      (49)                      
      Basophilic Focus                                 3 (6%)                                                                       
      Basophilic Focus, Multiple                                                 1 (2%)                    1 (2%)                   
      Acinar Cell, Atrophy                            14 (28%)                  11 (22%)                  15 (31%)                  
      Acinar Cell, Hyperplasia                         6 (12%)                   4 (8%)                    4 (8%)                   
   Pharynx                                                                                                (2)                       
      Palate, Epithelium, Hyperplasia                                                                      1 (50%)                  
   Salivary Glands                                    (50)         (10)         (49)                      (50)                      
      Cytomegaly                                                                                           1 (2%)                   
      Infiltration Cellular, Lipocyte                                                                      1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Acinar Cell, Atrophy                             1 (2%)                                              1 (2%)                   
      Acinar Cell, Hyperplasia                         1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (10)         (50)         (1)          (50)                      
      Edema                                            4 (8%)                    1 (2%)                    5 (10%)                  
      Inflammation, Chronic                            4 (8%)                    2 (4%)                    2 (4%)                   
      Inflammation, Suppurative                                                                            2 (4%)                   
      Ulcer                                            1 (2%)                                              2 (4%)                   
      Ulcer, Multiple                                  2 (4%)                    1 (2%)                    2 (4%)                   
      Epithelium, Hyperplasia                          8 (16%)                   8 (16%)      1 (100%)    13 (26%)                  
   Stomach, Glandular                                 (50)         (10)         (50)         (1)          (50)                      
      Edema                                            1 (2%)                                                                       
      Erosion                                                                    1 (2%)                    1 (2%)                   
      Erosion, Multiple                                1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
      Mineralization                                                             1 (2%)                    1 (2%)                   
      Necrosis, Focal, Multiple                                                  1 (2%)                    1 (2%)                   
      Ulcer                                                                      1 (2%)                                             
      Ulcer, Multiple                                                                                      1 (2%)                   
      Epithelium, Hyperplasia                          1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                      (50)                      
      Inflammation, Chronic                           34 (68%)      1 (10%)     45 (90%)                  41 (82%)                  
      Atrium, Congestion                                                         1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (50)                      (50)                      
      Accessory Adrenal Cortical Nodule                6 (12%)                   4 (8%)                    2 (4%)                   
      Degeneration, Cystic                                                                                 1 (2%)                   
      Hyperplasia, Focal                               4 (8%)                   10 (20%)                   5 (10%)                  
      Hyperplasia, Focal, Multiple                                                                         1 (2%)                   
      Hypertrophy, Focal                               7 (14%)                  11 (22%)                   6 (12%)                  
      Hypertrophy, Focal, Multiple                                               2 (4%)                                             
      Necrosis, Focal, Multiple                                                  1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)                    3 (6%)                    2 (4%)                   
      Vacuolization Cytoplasmic, Focal                14 (28%)                  15 (30%)                   8 (16%)                  
      Vacuolization Cytoplasmic, Multiple                                        2 (4%)                                             
      Bilateral, Hypertrophy, Focal                    1 (2%)                                                                       
      Bilateral, Vacuolization Cytoplasmic             1 (2%)                    1 (2%)                                             
      Bilateral, Vacuolization Cytoplasmic, Focal                                1 (2%)                                             
      Spindle Cell, Hyperplasia, Focal                 1 (2%)       1 (10%)                                                         
   Adrenal Gland, Medulla                             (50)         (10)         (50)                      (50)                      
      Degeneration, Cystic, Focal                                                1 (2%)                                             
      Hyperplasia, Focal                               3 (6%)                    4 (8%)                    3 (6%)                   
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
   Parathyroid Gland                                  (49)         (10)         (46)                      (49)                      
      Cyst                                                                                                 1 (2%)                   
   Pituitary Gland                                    (50)         (10)         (50)         (3)          (50)         (1)          
      Pars Distalis, Cyst                              4 (8%)                    4 (8%)                    3 (6%)                   
      Pars Distalis, Cyst, Multiple                    4 (8%)                    4 (8%)       1 (33%)      1 (2%)       1 (100%)    
      Pars Distalis, Hyperplasia, Focal                5 (10%)      1 (10%)      6 (12%)                   6 (12%)                  
      Pars Intermedia, Cyst                                                                                1 (2%)                   
   Thyroid Gland                                      (50)         (10)         (50)                      (50)         (1)          
      Inflammation, Suppurative                                                                            1 (2%)                   
      Ultimobranchial Cyst                             1 (2%)                                              2 (4%)                   
      C-Cell, Hyperplasia                              5 (10%)                   3 (6%)                    1 (2%)                   
      C-Cell, Hyperplasia, Focal                       9 (18%)                   7 (14%)                   5 (10%)                  
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (10)         (47)         (10)         (50)         (10)         
      Abscess                                          1 (2%)                                                                       
      Atrophy                                          1 (2%)                                                                       
      Cyst                                            14 (31%)      3 (30%)     23 (49%)      2 (20%)     18 (36%)      3 (30%)     
      Cyst, Multiple                                   1 (2%)                                                           1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hyperplasia                                      8 (18%)                                             1 (2%)                   
      Hyperplasia, Focal                               1 (2%)                    4 (9%)                    1 (2%)                   
      Inflammation, Suppurative                        2 (4%)                    1 (2%)                    2 (4%)                   
      Bilateral, Cyst                                  7 (16%)                   3 (6%)                   11 (22%)                  
   Ovary                                              (50)         (10)         (50)                      (50)                      
      Cyst                                             5 (10%)      1 (10%)      3 (6%)                    5 (10%)                  
      Inflammation, Granulomatous, Multiple                                      1 (2%)                                             
      Bilateral, Cyst                                  1 (2%)       1 (10%)                                1 (2%)                   
   Uterus                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Abscess                                                                    1 (2%)                                             
      Dilatation                                       2 (4%)       2 (20%)      3 (6%)       1 (10%)      2 (4%)       1 (10%)     
      Hyperplasia, Glandular                           2 (4%)                    2 (4%)                    2 (4%)                   
      Infiltration Cellular, Lipocyte                                                                      1 (2%)                   
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                    1 (2%)                   
      Cervix, Abscess                                                                         1 (10%)                               
      Cervix, Cyst                                     2 (4%)                                 1 (10%)                               
      Cervix, Inflammation, Suppurative                1 (2%)                    1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                 7 (14%)      2 (20%)      6 (12%)      1 (10%)      9 (18%)                  
   Vagina                                                                       (3)                       (1)                       
      Inflammation, Suppurative                                                  1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)         (50)                      (50)                      
      Hyperplasia, Reticulum Cell                                   1 (10%)                                                         
      Myelofibrosis                                    2 (4%)                    1 (2%)                                             
      Erythroid Cell, Hyperplasia                                                                          1 (2%)                   
   Lymph Node                                         (50)         (10)         (50)                      (50)                      
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Mediastinal, Angiectasis                         6 (12%)                   2 (4%)                    5 (10%)                  
      Mediastinal, Hemorrhage                                                                              1 (2%)                   
      Mediastinal, Hyperplasia, Lymphoid                            1 (10%)      3 (6%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                                       1 (2%)                   
      Mediastinal, Pigmentation                                                  1 (2%)                                             
      Pancreatic, Angiectasis                                                    2 (4%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                                                    1 (2%)                   
      Pancreatic, Pigmentation                                      1 (10%)                                                         
      Renal, Cyst, Multiple                                                      1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (10)         (49)                      (50)                      
      Angiectasis                                      1 (2%)                    2 (4%)                                             
      Congestion                                                                 1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Cyst, Multiple                                   3 (6%)                    2 (4%)                    3 (6%)                   
      Hyperplasia, Lymphoid                            7 (15%)                   2 (4%)                    2 (4%)                   
   Lymph Node, Mesenteric                             (48)         (10)         (50)                      (50)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Angiectasis                                      1 (2%)                    3 (6%)                    2 (4%)                   
      Edema                                                                      1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                              1 (2%)                   
   Spleen                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Atrophy                                                                    1 (2%)                    1 (2%)                   
      Congestion                                                                 2 (4%)                                             
      Fibrosis, Focal                                  2 (4%)                    1 (2%)                    1 (2%)                   
      Hematopoietic Cell Proliferation                 2 (4%)                    2 (4%)      10 (100%)     5 (10%)      8 (80%)     
      Inflammation, Granulomatous                                                2 (4%)                                             
      Necrosis                                                                                             1 (2%)                   
      Pigmentation                                     3 (6%)                    5 (10%)     10 (100%)     2 (4%)      10 (100%)    
      Capsule, Fibrosis                                                          1 (2%)                                             
      Capsule, Hypertrophy                                                       1 (2%)       3 (30%)                   3 (30%)     
      Capsule, Inflammation, Granulomatous                                       1 (2%)                                             
   Thymus                                             (47)         (10)         (49)                      (47)                      
      Cyst                                                                       3 (6%)                                             
      Cyst, Multiple                                                             1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)         (50)                      (50)                      
      Hyperplasia, Lobular                            19 (38%)                  26 (52%)                  22 (44%)                  
      Duct, Cyst                                      38 (76%)      1 (10%)     36 (72%)                  33 (66%)                  
   Skin                                               (50)         (10)         (50)                      (50)                      
      Hyperkeratosis                                                             2 (4%)                                             
      Parakeratosis                                                              2 (4%)                                             
      Ulcer                                                                      2 (4%)                                             
      Nipple, Hyperkeratosis                                                                               1 (2%)                   
      Nipple, Hyperplasia                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                      (50)                      
      Osteopetrosis                                    2 (4%)                    1 (2%)                    1 (2%)                   
      Calvarium, Hyperostosis                          6 (12%)      1 (10%)      5 (10%)                   4 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                      (50)                      
      Compression                                     10 (20%)                   6 (12%)                  13 (26%)                  
      Embolus Bacterial, Multiple                                                1 (2%)                                             
      Hemorrhage                                                                 2 (4%)                    2 (4%)                   
      Hemorrhage, Multiple                                                                                 1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Inflammation, Multiple, Suppurative                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (50)                      (50)         (1)          
      Atelectasis                                      1 (2%)                                                                       
      Congestion                                                                                           1 (2%)                   
      Edema                                            1 (2%)                                                                       
      Embolus Bacterial, Multiple                                                1 (2%)                                             
      Hemorrhage, Multiple                                                       1 (2%)                                             
      Infiltration Cellular, Focal, Histiocyte         1 (2%)                    1 (2%)                    4 (8%)                   
      Infiltration Cellular, Multiple, Histiocyte      1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (4%)                                                                       
      Inflammation, Focal, Granulomatous               3 (6%)                    2 (4%)                                             
      Inflammation, Multiple, Suppurative                                        1 (2%)                                             
      Mineralization, Focal                                                      1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                    1 (2%)                   
      Alveolar Epithelium, Hyperplasia, Focal                                    3 (6%)                    1 (2%)                   
   Nose                                               (50)         (10)         (50)         (3)          (50)         (6)          
      Metaplasia, Squamous                                                       1 (2%)                                             
      Lumen, Foreign Body                                                        1 (2%)                                             
      Lumen, Fungus                                    4 (8%)                    2 (4%)                    2 (4%)                   
      Lumen, Hyperkeratosis                                                      1 (2%)                                             
      Lumen, Inflammation, Suppurative                 4 (8%)                    3 (6%)                    2 (4%)                   
      Nasolacrimal Duct, Hemorrhage                                              1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
      Submucosa, Hemorrhage                                                      2 (4%)                                             
      Submucosa, Pigmentation                         46 (92%)      8 (80%)     48 (96%)      3 (100%)    46 (92%)      6 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (4)                       (1)                       
      Cataract                                                                   4 (100%)                  1 (100%)                 
      Retina, Degeneration                                                       4 (100%)                  1 (100%)                 
   Harderian Gland                                    (1)                       (2)                                                 
      Hemorrhage                                       1 (100%)                  2 (100%)                                           
   Zymbal's Gland                                     (1)                       (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Cyst                                                                       2 (4%)                                 1 (10%)     
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Infarct, Multiple                                                                                    1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic, Focal                                  1 (10%)                                                         
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                             2 (4%)                                             
      Nephropathy, Chronic                            39 (78%)      3 (30%)     46 (92%)      9 (90%)     46 (92%)      5 (50%)     
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Dilatation                                                                                   1 (2%)                   
      Renal Tubule, Dilatation                                      1 (10%)                                             6 (60%)     
      Renal Tubule, Mineralization                     1 (2%)       1 (10%)      1 (2%)       6 (60%)      3 (6%)       7 (70%)     
      Renal Tubule, Pigmentation                      41 (82%)                  47 (94%)                  45 (90%)                  
      Transitional Epithelium, Hyperplasia                                       1 (2%)                    1 (2%)                   
   Urinary Bladder                                    (50)         (10)         (50)         (10)         (50)         (10)         
      Calculus Gross Observation                                                 1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10                                                               
  Scheduled Sacrifice                                               9                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14            1                                                               
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                                                                            
  Animals Examined Microscopically                    50           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (10)                                                             
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (10)                                                             
      Parasite Metazoan                                2 (4%)       1 (10%)                                                         
   Intestine Large, Rectum                            (49)         (10)                                                             
      Parasite Metazoan                                6 (12%)                                                                      
   Intestine Small                                    (50)         (10)                                                             
      Wall, Foreign Body                               1 (2%)                                                                       
   Intestine Small, Jejunum                           (48)         (10)                                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                 3 (6%)       2 (20%)                                                         
      Basophilic Focus, Multiple                      26 (52%)      1 (10%)                                                         
      Clear Cell Focus                                 3 (6%)                                                                       
      Clear Cell Focus, Multiple                       2 (4%)                                                                       
      Eosinophilic Focus                               9 (18%)                                                                      
      Eosinophilic Focus, Multiple                     5 (10%)                                                                      
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       8 (16%)      1 (10%)                                                         
      Hyperplasia, Nodular                            14 (28%)                                                                      
      Inflammation, Granulomatous, Multiple           21 (42%)      5 (50%)                                                         
      Mixed Cell Focus                                 5 (10%)      1 (10%)                                                         
      Necrosis                                                      1 (10%)                                                         
      Vacuolization Cytoplasmic                        5 (10%)                                                                      
      Bile Duct, Hyperplasia                          43 (86%)      4 (40%)                                                         
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic         1 (2%)                                                                       
      Hepatocyte, Kupffer Cell, Pigmentation                        1 (10%)                                                         
      Vein, Thrombosis                                 1 (2%)                                                                       
   Mesentery                                          (12)         (4)                                                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (8%)                                                                       
      Fat, Inflammation, Focal, Granulomatous          1 (8%)       3 (75%)                                                         
      Fat, Necrosis, Focal                            10 (83%)      2 (50%)                                                         
   Pancreas                                           (50)         (10)                                                             
      Basophilic Focus, Multiple                       2 (4%)                                                                       
      Ectopic Tissue                                   1 (2%)                                                                       
      Acinar Cell, Atrophy                            12 (24%)                                                                      
      Acinar Cell, Hyperplasia                         5 (10%)                                                                      
   Salivary Glands                                    (50)         (10)                                                             
      Acinar Cell, Atrophy                             1 (2%)                                                                       
      Acinar Cell, Hyperplasia                         1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (10)                                                             
      Edema                                            5 (10%)                                                                      
      Inflammation, Chronic                            6 (12%)                                                                      
      Ulcer                                            6 (12%)                                                                      
      Ulcer, Multiple                                  1 (2%)                                                                       
      Epithelium, Hyperplasia                         28 (56%)      1 (10%)                                                         
   Stomach, Glandular                                 (50)         (10)                                                             
      Erosion                                          2 (4%)                                                                       
      Ulcer                                            2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)                                                             
      Inflammation, Chronic                           39 (78%)      2 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)                                                             
      Accessory Adrenal Cortical Nodule                7 (14%)                                                                      
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             2 (4%)                                                                       
      Hyperplasia, Focal                               6 (12%)                                                                      
      Hypertrophy, Focal                               5 (10%)                                                                      
      Vacuolization Cytoplasmic, Focal                11 (22%)                                                                      
      Bilateral, Hyperplasia                           1 (2%)                                                                       
      Bilateral, Vacuolization Cytoplasmic             3 (6%)                                                                       
      Bilateral, Vacuolization Cytoplasmic, Focal      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (10)                                                             
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Cyst                              5 (10%)                                                                      
      Pars Distalis, Cyst, Multiple                    6 (12%)      1 (10%)                                                         
      Pars Distalis, Hyperplasia                       4 (8%)       1 (10%)                                                         
      Pars Distalis, Hyperplasia, Focal                7 (14%)                                                                      
      Pars Intermedia, Cyst                                         1 (10%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)                                                             
      C-Cell, Hyperplasia                              2 (4%)                                                                       
      C-Cell, Hyperplasia, Focal                       5 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (10)                                                             
      Cyst                                            15 (31%)      1 (10%)                                                         
      Hyperplasia                                      6 (13%)      2 (20%)                                                         
      Inflammation, Suppurative                        2 (4%)                                                                       
      Bilateral, Cyst                                 11 (23%)                                                                      
   Ovary                                              (50)         (10)                                                             
      Cyst                                             5 (10%)                                                                      
      Cyst, Multiple                                   1 (2%)                                                                       
   Uterus                                             (50)         (10)                                                             
      Dilatation                                       4 (8%)       1 (10%)                                                         
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Glandular                           5 (10%)                                                                      
      Cervix, Hemorrhage                               1 (2%)                                                                       
      Cervix, Myometrium, Hyperplasia                  3 (6%)                                                                       
      Endometrium, Hyperplasia, Cystic                12 (24%)                                                                      
      Vein, Thrombosis                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (10)                                                             
      Mediastinal, Angiectasis                         6 (12%)                                                                      
      Mediastinal, Congestion                          1 (2%)                                                                       
      Mediastinal, Hemorrhage                          1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid               2 (4%)                                                                       
      Mediastinal, Pigmentation                        2 (4%)                                                                       
      Pancreatic, Angiectasis                          6 (12%)                                                                      
   Lymph Node, Mandibular                             (50)         (10)                                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Pigmentation                                     2 (4%)                                                                       
   Lymph Node, Mesenteric                             (47)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Spleen                                             (50)         (10)                                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 3 (6%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Pigmentation                                     1 (2%)       1 (10%)                                                         
   Thymus                                             (48)         (10)                                                             
      Congestion                                       1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Mediastinum, Edema                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)                                                             
      Hyperplasia, Lobular                            21 (42%)                                                                      
      Duct, Cyst                                      34 (68%)                                                                      
   Skin                                               (50)         (10)                                                             
      Hyperkeratosis                                   1 (2%)                                                                       
      Epidermis, Hyperplasia                           1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)                                                             
      Osteopetrosis                                    1 (2%)                                                                       
      Calvarium, Hyperostosis                          5 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)                                                             
      Compression                                      6 (12%)                                                                      
      Hemorrhage, Multiple                             2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)                                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Infiltration Cellular, Focal, Histiocyte         2 (4%)                                                                       
      Infiltration Cellular, Multiple, Histiocyte      2 (4%)                                                                       
      Inflammation, Focal, Granulomatous               4 (8%)                                                                       
      Inflammation, Granulomatous, Multiple            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                                                       
      Alveolus, Pigmentation                           2 (4%)                                                                       
   Nose                                               (50)         (10)                                                             
      Lumen, Fungus                                    1 (2%)                                                                       
      Lumen, Inflammation, Suppurative                 1 (2%)                                                                       
      Submucosa, Pigmentation                         50 (100%)    10 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)                                                                           
      Cataract                                         4 (80%)                                                                      
      Inflammation, Suppurative                        1 (20%)                                                                      
      Retina, Degeneration                             4 (80%)                                                                      
   Harderian Gland                                    (2)                                                                           
      Hemorrhage                                       1 (50%)                                                                      
   Zymbal's Gland                                     (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)                                                             
      Nephropathy, Chronic                            44 (88%)      4 (40%)                                                         
      Renal Tubule, Dilatation                         1 (2%)       8 (80%)                                                         
      Renal Tubule, Mineralization                     2 (4%)       6 (60%)                                                         
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Pigmentation                      46 (92%)                                                                      
   Urinary Bladder                                    (50)         (10)                                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
      Inflammation, Chronic                            2 (4%)                                                                       
      Transitional Epithelium, Hyperplasia             6 (12%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           50           10           50           10           
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
    Natural Death                                      2                         3                         2                        
    Moribund Sacrifice                                16                        13                        24                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                32                        34                        24                        
  Animals Examined Microscopically                    50           10           50           10           50           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (10)         (48)                      (49)                      
      Dilatation                                                                                           1 (2%)                   
      Parasite Metazoan                                1 (2%)                                              3 (6%)                   
   Intestine Large, Colon                             (48)         (10)         (48)                      (50)                      
      Dilatation                                                                                           1 (2%)                   
      Parasite Metazoan                                5 (10%)      4 (40%)      4 (8%)                    2 (4%)                   
   Intestine Large, Rectum                            (46)         (10)         (49)                      (50)                      
      Dilatation                                                                                           1 (2%)                   
      Parasite Metazoan                                9 (20%)                   4 (8%)                   13 (26%)                  
   Intestine Small, Duodenum                          (49)         (10)         (47)                      (50)                      
      Ectopic Tissue                                                             1 (2%)                                             
   Intestine Small, Ileum                             (48)         (10)         (47)                      (48)                      
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                    4 (8%)                   
   Liver                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Angiectasis                                                                                          1 (2%)                   
      Basophilic Focus                                 3 (6%)       5 (50%)      2 (4%)       1 (10%)      2 (4%)                   
      Basophilic Focus, Multiple                      29 (58%)                  27 (54%)                  11 (22%)                  
      Clear Cell Focus                                 6 (12%)      3 (30%)      4 (8%)                    1 (2%)       1 (10%)     
      Clear Cell Focus, Multiple                       7 (14%)      2 (20%)      6 (12%)      1 (10%)      4 (8%)                   
      Degeneration, Cystic                            10 (20%)      1 (10%)     10 (20%)                  14 (28%)                  
      Eosinophilic Focus                               6 (12%)                  10 (20%)      1 (10%)     15 (30%)      3 (30%)     
      Eosinophilic Focus, Multiple                     2 (4%)                    8 (16%)      1 (10%)      6 (12%)                  
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                       4 (8%)                    3 (6%)                    2 (4%)       1 (10%)     
      Hepatodiaphragmatic Nodule, Multiple                          1 (10%)                                                         
      Hyperplasia, Nodular                             7 (14%)                   2 (4%)                   18 (36%)                  
      Inflammation, Granulomatous, Multiple            2 (4%)       5 (50%)      2 (4%)       4 (40%)      2 (4%)       6 (60%)     
      Mixed Cell Focus                                 4 (8%)       2 (20%)                                2 (4%)                   
      Mixed Cell Focus, Multiple                       2 (4%)                    2 (4%)                    1 (2%)                   
      Necrosis                                                                   1 (2%)                                             
      Thrombosis, Multiple                                                       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Vacuolization Cytoplasmic                        5 (10%)      8 (80%)      4 (8%)      10 (100%)     4 (8%)       8 (80%)     
      Bile Duct, Hyperplasia                          46 (92%)     10 (100%)    44 (88%)     10 (100%)    46 (92%)      7 (70%)     
      Centrilobular, Degeneration                      2 (4%)                    2 (4%)                    2 (4%)                   
   Mesentery                                          (10)         (2)          (11)         (2)          (5)          (2)          
      Accessory Spleen                                                                                                  1 (50%)     
      Fat, Hemorrhage, Focal                           2 (20%)                                                          1 (50%)     
      Fat, Inflammation, Focal, Granulomatous          1 (10%)      1 (50%)      4 (36%)      1 (50%)                               
      Fat, Necrosis, Focal                             7 (70%)                   9 (82%)      1 (50%)      3 (60%)                  
   Pancreas                                           (49)         (10)         (49)                      (50)         (1)          
      Basophilic Focus                                 2 (4%)                                                                       
      Ectopic Tissue                                   1 (2%)                                                                       
      Edema                                                                      1 (2%)                    1 (2%)                   
      Polyarteritis                                    1 (2%)                    1 (2%)                                             
      Acinar Cell, Atrophy                            18 (37%)                  21 (43%)                  18 (36%)                  
      Acinar Cell, Basophilic Focus                                              2 (4%)                                             
      Acinar Cell, Hyperplasia                         6 (12%)                  10 (20%)                   4 (8%)                   
      Acinar Cell, Hyperplasia, Focal                                            1 (2%)                                             
      Acinar Cell, Vacuolization Cytoplasmic                                                               1 (2%)                   
   Salivary Glands                                    (50)         (10)         (50)                      (50)                      
      Cytomegaly                                       1 (2%)                    8 (16%)                   4 (8%)                   
      Fibrosis, Focal                                                            1 (2%)                                             
      Infiltration Cellular, Lipocyte                                           39 (78%)                   6 (12%)                  
      Inflammation, Suppurative                        1 (2%)                                                                       
      Acinar Cell, Atrophy                                                       1 (2%)                    1 (2%)                   
   Stomach, Forestomach                               (50)         (10)         (50)                      (50)         (1)          
      Edema                                            3 (6%)                    3 (6%)                    5 (10%)                  
      Inflammation, Chronic                            2 (4%)                    2 (4%)                    1 (2%)                   
      Mineralization                                                                                       1 (2%)                   
      Perforation                                                                1 (2%)                                             
      Ulcer                                            3 (6%)                    3 (6%)                    6 (12%)                  
      Ulcer, Multiple                                                                                      2 (4%)                   
      Epithelium, Hyperplasia                          3 (6%)                   16 (32%)                  25 (50%)      1 (100%)    
   Stomach, Glandular                                 (50)         (10)         (49)                      (50)         (1)          
      Edema                                                                                                4 (8%)                   
      Erosion, Multiple                                                                                    1 (2%)                   
      Mineralization                                                             1 (2%)                    1 (2%)                   
      Ulcer                                                                                                1 (2%)                   
      Ulcer, Multiple                                                                                      1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)         (1)          (50)                      
      Inflammation, Chronic                           43 (86%)      6 (60%)     46 (92%)                  42 (84%)                  
      Atrium, Congestion                               2 (4%)                    1 (2%)                                             
      Atrium, Thrombosis                                                         2 (4%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (10)         (50)                      (50)                      
      Accessory Adrenal Cortical Nodule                8 (17%)      1 (10%)      5 (10%)                   5 (10%)                  
      Degeneration, Cystic                                                                                 1 (2%)                   
      Hyperplasia, Focal                               3 (6%)       1 (10%)      7 (14%)                   4 (8%)                   
      Hypertrophy, Focal                               5 (10%)                   2 (4%)                    1 (2%)                   
      Vacuolization Cytoplasmic                                                                            2 (4%)                   
      Vacuolization Cytoplasmic, Focal                 9 (19%)      1 (10%)     10 (20%)                  11 (22%)                  
      Vacuolization Cytoplasmic, Focal, Multiple                                 2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (10)         (50)                      (50)                      
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                               4 (8%)                    9 (18%)                  11 (22%)                  
      Bilateral, Hyperplasia, Focal                                              1 (2%)                                             
   Islets, Pancreatic                                 (49)         (10)         (49)                      (50)                      
      Hyperplasia                                      1 (2%)                    2 (4%)                    2 (4%)                   
   Parathyroid Gland                                  (47)         (10)         (46)                      (47)                      
      Hyperplasia                                      2 (4%)                    1 (2%)                    3 (6%)                   
   Pituitary Gland                                    (50)         (10)         (50)         (1)          (49)                      
      Pars Distalis, Cyst                              2 (4%)                    1 (2%)                    6 (12%)                  
      Pars Distalis, Cyst, Multiple                                              1 (2%)                                             
      Pars Distalis, Hemorrhage                        4 (8%)                                                                       
      Pars Distalis, Hyperplasia, Focal                3 (6%)       3 (30%)      9 (18%)                  11 (22%)                  
      Pars Intermedia, Cyst                                                                                2 (4%)                   
   Thyroid Gland                                      (49)         (10)         (50)                      (50)                      
      Ultimobranchial Cyst                                                       1 (2%)                                             
      Bilateral, C-Cell, Hyperplasia                                             1 (2%)                                             
      C-Cell, Hyperplasia                                                                                  3 (6%)                   
      C-Cell, Hyperplasia, Focal                       7 (14%)                   3 (6%)                    3 (6%)                   
      Follicle, Cyst                                   4 (8%)                    5 (10%)                   6 (12%)                  
      Follicular Cell, Hyperplasia                                               1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                                                      (1)                       
      Inflammation, Suppurative                                                                            1 (100%)                 
   Epididymis                                         (50)         (10)         (50)         (10)         (50)         (10)         
      Granuloma Sperm                                  1 (2%)                                                                       
   Preputial Gland                                    (50)         (10)         (50)         (10)         (50)         (9)          
      Abscess                                                                                              1 (2%)                   
      Atrophy                                          6 (12%)                  13 (26%)                  16 (32%)      2 (22%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Atrophy, Multiple                                                          3 (6%)                    1 (2%)                   
      Autolysis                                                                                            1 (2%)                   
      Cyst                                             7 (14%)      3 (30%)     18 (36%)      2 (20%)     24 (48%)      2 (22%)     
      Cyst, Multiple                                   2 (4%)                    4 (8%)                    7 (14%)                  
      Hyperplasia                                      2 (4%)       1 (10%)                                5 (10%)                  
      Hyperplasia, Focal                               1 (2%)                    3 (6%)                                             
      Inflammation, Chronic                            2 (4%)                    1 (2%)                    1 (2%)                   
      Inflammation, Suppurative                        3 (6%)                    5 (10%)                   3 (6%)                   
   Prostate                                           (50)         (10)         (50)                      (50)                      
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                            4 (8%)                    6 (12%)                   2 (4%)                   
      Inflammation, Suppurative                       24 (48%)      3 (30%)     15 (30%)                  17 (34%)                  
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Seminal Vesicle                                    (50)         (10)         (50)                      (50)         (1)          
      Atrophy                                         12 (24%)                  12 (24%)                   7 (14%)      1 (100%)    
      Hyperplasia, Glandular                                                                               1 (2%)                   
   Testes                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Atrophy                                         16 (32%)                  13 (26%)                  15 (30%)      1 (10%)     
      Bilateral, Atrophy                                                         1 (2%)                    2 (4%)                   
      Bilateral, Interstitial Cell, Hyperplasia        3 (6%)       6 (60%)      5 (10%)      3 (30%)      3 (6%)       5 (50%)     
      Interstitial Cell, Atrophy                                                                           2 (4%)                   
      Interstitial Cell, Hyperplasia                  16 (32%)      1 (10%)      6 (12%)      4 (40%)     15 (30%)      4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)         (50)                      (50)                      
      Myelofibrosis                                                              1 (2%)                    2 (4%)                   
      Myeloid Cell, Hyperplasia                        1 (2%)                                                                       
   Lymph Node                                         (50)         (10)         (50)                      (50)         (1)          
      Inguinal, Hyperplasia, Lymphoid                  3 (6%)                                              1 (2%)                   
      Mediastinal, Angiectasis                         9 (18%)                   5 (10%)                   2 (4%)                   
      Mediastinal, Cyst, Multiple                                                                          1 (2%)                   
      Mediastinal, Hyperplasia, Lymphoid               2 (4%)       1 (10%)      2 (4%)                    1 (2%)                   
      Mediastinal, Pigmentation                        2 (4%)                                              1 (2%)                   
      Pancreatic, Angiectasis                          2 (4%)                    2 (4%)                    2 (4%)                   
      Pancreatic, Cyst, Multiple                                                                           1 (2%)                   
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                    1 (2%)                                 1 (100%)    
      Pancreatic, Pigmentation                         2 (4%)                                                                       
      Renal, Hyperplasia, Lymphoid                                                                         1 (2%)                   
      Renal, Pigmentation                                                                                  1 (2%)                   
   Lymph Node, Mandibular                             (50)         (10)         (48)                      (50)                      
      Angiectasis                                      1 (2%)                    1 (2%)                    1 (2%)                   
      Cyst, Multiple                                   3 (6%)                    6 (13%)                   3 (6%)                   
      Fibrosis                                                                                             1 (2%)                   
      Hyperplasia, Lymphoid                            4 (8%)                    3 (6%)                    3 (6%)                   
   Lymph Node, Mesenteric                             (49)         (10)         (48)                      (49)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Angiectasis                                      1 (2%)                    2 (4%)                    1 (2%)                   
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    6 (13%)                   1 (2%)                   
   Spleen                                             (50)         (10)         (49)         (10)         (50)         (10)         
      Congestion                                                    1 (10%)      7 (14%)                                1 (10%)     
      Fibrosis, Focal                                  7 (14%)                   5 (10%)                   8 (16%)                  
      Hematopoietic Cell Proliferation                 3 (6%)                    1 (2%)                    1 (2%)                   
      Hyperplasia, Histiocytic, Lymphoid                                                                   1 (2%)                   
      Inflammation, Granulomatous, Multiple                                                                1 (2%)                   
      Necrosis                                                                                             2 (4%)                   
      Capsule, Fibrosis, Focal                                                                1 (10%)                               
      Capsule, Hypertrophy                                                       1 (2%)       5 (50%)                   6 (60%)     
   Thymus                                             (45)         (9)          (48)                      (42)                      
      Fibrosis                                                                                             1 (2%)                   
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (10)         (49)                      (47)                      
      Hyperplasia, Lobular                            10 (21%)                  21 (43%)                  13 (28%)                  
      Duct, Cyst                                       7 (15%)                  17 (35%)                  16 (34%)                  
      Duct, Hemorrhage                                 1 (2%)                    3 (6%)                                             
   Skin                                               (50)         (10)         (50)         (1)          (50)                      
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                             1 (2%)                                             
      Dermis, Fibrosis                                                           1 (2%)                                             
      Epidermis, Hyperplasia                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                      (50)                      
      Fibrous Osteodystrophy                                                     1 (2%)                    1 (2%)                   
      Osteoporosis                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                      (50)                      
      Compression                                      6 (12%)                   3 (6%)                    4 (8%)                   
      Hemorrhage                                       2 (4%)                                              3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (50)         (1)          (50)                      
      Atelectasis, Focal                               1 (2%)                                                                       
      Erythrophagocytosis                                                        1 (2%)                                             
      Hemorrhage, Focal                                                          1 (2%)                                             
      Infiltration Cellular, Focal, Histiocyte                                                             4 (8%)                   
      Infiltration Cellular, Multiple, Histiocyte                                2 (4%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Focal, Granulomatous                                         2 (4%)                    1 (2%)                   
      Inflammation, Granulomatous, Multiple            3 (6%)                                                                       
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       1 (10%)                                1 (2%)                   
      Alveolar Epithelium, Hyperplasia, Focal                                    1 (2%)                    1 (2%)                   
   Nose                                               (50)         (10)         (50)                      (50)                      
      Lumen, Foreign Body                              1 (2%)                    3 (6%)                    5 (10%)                  
      Lumen, Fungus                                   10 (20%)                   9 (18%)                   9 (18%)                  
      Lumen, Inflammation, Suppurative                 9 (18%)                  12 (24%)                  13 (26%)                  
      Respiratory Epithelium, Hyperkeratosis                                                               1 (2%)                   
      Respiratory Epithelium, Hyperplasia                                                                  1 (2%)                   
      Septum, Inflammation, Chronic                                                                        1 (2%)                   
      Submucosa, Inflammation, Suppurative                                                                 1 (2%)                   
      Submucosa, Pigmentation                                                   45 (90%)                  37 (74%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)                       (2)          (1)          
      Cataract                                         1 (100%)                  1 (100%)                               1 (100%)    
      Retina, Degeneration                             1 (100%)                  1 (100%)                  1 (50%)      1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (10)         (50)         (10)         (50)         (10)         
      Cyst                                             1 (2%)                    2 (4%)                    2 (4%)                   
      Cyst, Multiple                                                             1 (2%)                                             
      Fibrosis, Focal                                               1 (10%)                                                         
      Nephropathy, Chronic                            49 (100%)    10 (100%)    50 (100%)    10 (100%)    50 (100%)    10 (100%)    
      Pelvis, Dilatation                                            1 (10%)                                                         
      Renal Tubule, Hyperplasia                                                  3 (6%)                                             
      Renal Tubule, Mineralization                                               2 (4%)                                             
      Renal Tubule, Pigmentation                      45 (92%)                  41 (82%)                  48 (96%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             7 (14%)                   9 (18%)                   9 (18%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10                                                               
  Scheduled Sacrifice                                               9                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                35            1                                                               
    Natural Death                                      6                                                                            
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                 8                                                                            
  Animals Examined Microscopically                    50           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (10)                                                             
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Colon                             (48)         (10)                                                             
      Mineralization                                   1 (2%)                                                                       
      Parasite Metazoan                                9 (19%)      4 (40%)                                                         
   Intestine Large, Rectum                            (49)         (10)                                                             
      Dilatation                                       1 (2%)                                                                       
      Edema                                            1 (2%)                                                                       
      Parasite Metazoan                                8 (16%)                                                                      
   Intestine Small, Jejunum                           (48)         (10)                                                             
      Parasite Metazoan                                             1 (10%)                                                         
      Artery, Thrombosis                               1 (2%)                                                                       
      Wall, Inflammation, Chronic                      1 (2%)                                                                       
   Liver                                              (50)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                 4 (8%)       1 (10%)                                                         
      Basophilic Focus, Multiple                       3 (6%)                                                                       
      Clear Cell Focus                                 2 (4%)       1 (10%)                                                         
      Clear Cell Focus, Multiple                       3 (6%)                                                                       
      Degeneration, Cystic                            24 (48%)                                                                      
      Eosinophilic Focus                              13 (26%)                                                                      
      Eosinophilic Focus, Multiple                    14 (28%)                                                                      
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage, Focal                                             1 (10%)                                                         
      Hepatodiaphragmatic Nodule                       4 (8%)       2 (20%)                                                         
      Hyperplasia, Nodular                            14 (28%)                                                                      
      Inflammation, Granulomatous, Multiple                         7 (70%)                                                         
      Mixed Cell Focus                                 2 (4%)                                                                       
      Necrosis                                         2 (4%)       1 (10%)                                                         
      Vacuolization Cytoplasmic                        1 (2%)       8 (80%)                                                         
      Bile Duct, Hyperplasia                          40 (80%)      9 (90%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   21                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Degeneration                      2 (4%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Vein, Thrombosis                                 1 (2%)                                                                       
   Mesentery                                          (9)                                                                           
      Polyarteritis                                    2 (22%)                                                                      
      Thrombosis, Multiple                             1 (11%)                                                                      
      Fat, Hemorrhage, Focal                           2 (22%)                                                                      
      Fat, Necrosis, Focal                             3 (33%)                                                                      
   Pancreas                                           (48)         (10)                                                             
      Ectopic Tissue                                   2 (4%)                                                                       
      Fibrosis, Focal                                  1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Polyarteritis                                    2 (4%)                                                                       
      Acinar Cell, Atrophy                            13 (27%)                                                                      
      Acinar Cell, Hyperplasia                         6 (13%)                                                                      
      Acinus, Atrophy                                               1 (10%)                                                         
   Stomach, Forestomach                               (50)         (10)                                                             
      Edema                                           11 (22%)                                                                      
      Inflammation, Chronic                           12 (24%)                                                                      
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                           15 (30%)                                                                      
      Ulcer, Multiple                                  1 (2%)                                                                       
      Epithelium, Hyperplasia                         32 (64%)      2 (20%)                                                         
   Stomach, Glandular                                 (50)         (10)                                                             
      Edema                                            1 (2%)                                                                       
      Erosion                                          1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                   6 (12%)                                                                      
      Polyarteritis                                    1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Artery, Thrombosis                               1 (2%)                                                                       
      Mucosa, Pigmentation, Focal                      1 (2%)                                                                       
      Serosa, Fibrosis, Focal                                       1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Mineralization                            1 (100%)                                                                     
      Mesenteric Artery, Mineralization                1 (100%)                                                                     
   Heart                                              (50)         (10)                                                             
      Inflammation, Chronic                           40 (80%)      5 (50%)                                                         
      Mineralization                                   1 (2%)                                                                       
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   22                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (10)                                                             
      Accessory Adrenal Cortical Nodule                2 (4%)       1 (10%)                                                         
      Degeneration, Cystic                             1 (2%)                                                                       
      Hyperplasia, Focal                               2 (4%)                                                                       
      Hypertrophy, Focal                               1 (2%)                                                                       
      Hypertrophy, Multiple                            1 (2%)                                                                       
      Vacuolization Cytoplasmic                       11 (22%)                                                                      
      Vacuolization Cytoplasmic, Focal                 8 (16%)                                                                      
      Vacuolization Cytoplasmic, Focal, Multiple       1 (2%)                                                                       
      Spindle Cell, Hyperplasia, Focal                 1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (10)                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Focal                              10 (20%)                                                                      
   Parathyroid Gland                                  (48)         (10)                                                             
      Hyperplasia                                     14 (29%)                                                                      
   Pituitary Gland                                    (49)         (10)                                                             
      Pars Distalis, Cyst                              2 (4%)                                                                       
      Pars Distalis, Hyperplasia, Focal                5 (10%)      2 (20%)                                                         
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)                                                             
      Ultimobranchial Cyst                             1 (2%)                                                                       
      Artery, Polyarteritis                            1 (2%)                                                                       
      C-Cell, Hyperplasia                              1 (2%)       1 (10%)                                                         
      C-Cell, Hyperplasia, Focal                       3 (6%)                                                                       
      Follicle, Cyst                                   5 (10%)      1 (10%)                                                         
      Follicle, Degeneration                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)                                                             
      Depletion Cellular                                            1 (10%)                                                         
   Preputial Gland                                    (49)         (10)                                                             
      Abscess                                          1 (2%)                                                                       
      Atrophy                                         13 (27%)                                                                      
      Cyst                                            16 (33%)      1 (10%)                                                         
      Cyst, Multiple                                   1 (2%)                                                                       
      Hyperplasia                                      2 (4%)                                                                       
      Inflammation, Suppurative                        2 (4%)                                                                       
      Bilateral, Atrophy                               4 (8%)                                                                       
   Prostate                                           (50)         (10)                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   23                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             3 (6%)                                                                       
      Granuloma                                                     1 (10%)                                                         
      Inflammation, Chronic                            3 (6%)                                                                       
      Inflammation, Suppurative                       17 (34%)      2 (20%)                                                         
   Seminal Vesicle                                    (50)         (10)                                                             
      Atrophy                                          2 (4%)                                                                       
   Testes                                             (50)         (10)                                                             
      Atrophy                                         17 (34%)      3 (30%)                                                         
      Degeneration                                                  2 (20%)                                                         
      Necrosis                                         1 (2%)       1 (10%)                                                         
      Arteriole, Inflammation, Chronic                 1 (2%)                                                                       
      Bilateral, Atrophy                               1 (2%)                                                                       
      Bilateral, Interstitial Cell, Hyperplasia        5 (10%)      1 (10%)                                                         
      Interstitial Cell, Hyperplasia                  10 (20%)      5 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)                                                             
      Myelofibrosis                                    2 (4%)                                                                       
   Lymph Node                                         (50)         (10)                                                             
      Iliac, Cyst                                      1 (2%)                                                                       
      Inguinal, Hyperplasia, Lymphoid                  3 (6%)                                                                       
      Mediastinal, Angiectasis                         2 (4%)                                                                       
      Mediastinal, Pigmentation                        4 (8%)                                                                       
      Pancreatic, Angiectasis                          1 (2%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                3 (6%)                                                                       
      Renal, Angiectasis                               4 (8%)                                                                       
      Renal, Hyperplasia, Lymphoid                     1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Lymph Node, Mesenteric                             (48)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Edema                                            1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Spleen                                             (50)         (10)                                                             
      Congestion                                                    3 (30%)                                                         
      Fibrosis, Focal                                  9 (18%)                                                                      
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
      Capsule, Hypertrophy                                          8 (80%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   24                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)                                                             
      Hyperplasia, Lobular                            23 (46%)                                                                      
      Duct, Cyst                                       7 (14%)                                                                      
   Skin                                               (50)         (10)                                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Epidermis, Hyperplasia                           1 (2%)                                                                       
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
          Inclusion                                                 1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)                                                             
      Calvarium, Hyperostosis                          1 (2%)                                                                       
      Femur, Fibrous Osteodystrophy                    4 (8%)                                                                       
      Maxilla, Fibrous Osteodystrophy                  3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)                                                             
      Compression                                      2 (4%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)                                                             
      Hemorrhage, Multiple                             1 (2%)                                                                       
      Inflammation, Focal, Granulomatous                            2 (20%)                                                         
      Inflammation, Granulomatous, Multiple            1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Alveolus, Pigmentation                           1 (2%)                                                                       
      Mediastinum, Polyarteritis, Multiple             1 (2%)                                                                       
      Mediastinum, Thrombosis, Multiple                1 (2%)                                                                       
   Nose                                               (50)         (10)                                                             
      Metaplasia, Squamous                             2 (4%)                                                                       
      Lumen, Foreign Body                              2 (4%)                                                                       
      Lumen, Fungus                                   14 (28%)      1 (10%)                                                         
      Lumen, Inflammation, Suppurative                14 (28%)      1 (10%)                                                         
      Submucosa, Pigmentation                         45 (90%)      7 (70%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   25                                                              
NTP Experiment-Test: 05092-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                                                                           
      Cataract                                         1 (50%)                                                                      
      Retina, Degeneration                             1 (50%)                                                                      
   Harderian Gland                                    (2)                                                                           
      Hemorrhage                                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (10)                                                             
      Cyst                                             6 (12%)                                                                      
      Cyst, Multiple                                   7 (14%)                                                                      
      Hydronephrosis                                   1 (2%)                                                                       
      Nephropathy, Chronic                            49 (100%)    10 (100%)                                                        
      Renal Tubule, Hyperplasia                        2 (4%)                                                                       
      Renal Tubule, Pigmentation                      46 (94%)                                                                      
      Transitional Epithelium, Hyperplasia            30 (61%)                                                                      
   Ureter                                             (1)                                                                           
      Transitional Epithelium, Hyperplasia             1 (100%)                                                                     
   Urinary Bladder                                    (50)         (10)                                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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