TDMS Study 05092-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
O-NITROANISOLE
NTP Experiment-Test: 05092-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
Facility: Southern Research Institute
Chemical CAS #: 0091-23-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 17 7 18
Natural Death 2 6
Survivors
Terminal Sacrifice 33 41 26
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (10) (49) (46)
Intestine Large, Colon (50) (10) (49) (46)
Intestine Large, Rectum (50) (10) (49) (46)
Intestine Small, Ileum (50) (10) (49) (46)
Intestine Small, Jejunum (50) (10) (49) (47)
Liver (50) (10) (50) (10) (50) (10)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Mesentery (9) (1) (6) (2) (11)
Hemangiosarcoma 1 (17%)
Fat, Fibrosarcoma 1 (11%)
Fat, Lipoma 1 (17%)
Fat, Sarcoma Stromal, Metastatic, Uterus 1 (9%)
Pancreas (50) (10) (50) (49)
Pharynx (2)
Palate, Squamous Cell Carcinoma 1 (50%)
Stomach, Forestomach (50) (10) (50) (1) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (10) (50) (1) (50)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10) (50) (50)
Adenoma 1 (2%) 5 (10%)
Adrenal Gland, Medulla (50) (10) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (10) (50) (49)
Adenoma 2 (4%) 1 (2%) 2 (4%)
Carcinoma 1 (2%)
Pituitary Gland (50) (10) (50) (3) (50) (1)
Pars Distalis, Adenoma 28 (56%) 28 (56%) 2 (67%) 27 (54%) 1 (100%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (10) (50) (50) (1)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (8%) 3 (6%) 2 (4%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 1 (2%) 1 (100%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (10) (47) (10) (50) (10)
Adenoma 3 (7%) 5 (11%) 3 (6%) 1 (10%)
Carcinoma 4 (9%) 1 (2%) 2 (4%)
Bilateral, Carcinoma 1 (2%)
Ovary (50) (10) (50) (50)
Thecoma Benign 1 (2%)
Uterus (50) (10) (50) (10) (50) (10)
Hemangioma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 9 (18%) 3 (30%) 13 (26%) 8 (16%)
Sarcoma Stromal 3 (6%)
Cervix, Leiomyoma 1 (2%)
Cervix, Leiomyosarcoma 1 (2%)
Vagina (3) (1)
Polyp 1 (100%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10) (50) (50)
Lymph Node (50) (10) (50) (50)
Lymph Node, Mandibular (48) (10) (49) (50)
Lymph Node, Mesenteric (48) (10) (50) (50)
Spleen (50) (10) (50) (10) (50) (10)
Sarcoma 1 (2%)
Thymus (47) (10) (49) (47)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10) (50) (50)
Adenocarcinoma 2 (4%) 2 (4%)
Adenoma 1 (2%)
Fibroadenoma 17 (34%) 17 (34%) 12 (24%)
Fibroadenoma, Multiple 1 (2%) 3 (6%)
Skin (50) (10) (50) (50)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50) (50)
Maxilla, Squamous Cell Carcinoma, Metastatic,
Nose 1 (2%)
Skeletal Muscle (1) (1)
Abdominal, Lipoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (50) (50) (1)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (100%)
Nose (50) (10) (50) (3) (50) (6)
Respiratory Epithelium, Squamous Cell
Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Pinna, Schwannoma Malignant 1 (100%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (50) (10) (50) (10)
Myxosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10) *(50) *(10) *(50) *(10)
Leukemia Mononuclear 14 (28%) 11 (22%) 14 (28%) 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 3 46 2 46 5
Total Primary Neoplasms 99 3 101 2 93 6
Total Animals with Benign Neoplasms 40 3 44 2 38 3
Total Benign Neoplasms 73 3 80 2 62 3
Total Animals with Malignant Neoplasms 21 18 27 3
Total Malignant Neoplasms 26 21 31 3
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 2 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10
Scheduled Sacrifice 9
Early Deaths
Moribund Sacrifice 14 1
Natural Death 3
Survivors
Terminal Sacrifice 33
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (10)
Intestine Small, Jejunum (48) (10)
Liver (50) (10)
Hepatocellular Adenoma 3 (6%)
Mesentery (12) (4)
Pancreas (50) (10)
Acinar Cell, Adenoma 1 (2%)
Acinar Cell, Adenoma, Multiple 1 (2%)
Salivary Glands (50) (10)
Stomach, Forestomach (50) (10)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (10)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10)
Adenoma 2 (4%)
Adrenal Gland, Medulla (49) (10)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%)
Pituitary Gland (50) (10)
Pars Distalis, Adenoma 19 (38%)
Pars Distalis, Adenoma, Multiple 1 (10%)
Thyroid Gland (50) (10)
Page 7
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma 3 (6%) 1 (10%)
C-Cell, Carcinoma 1 (2%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (10)
Adenoma 3 (6%)
Carcinoma 2 (4%)
Ovary (50) (10)
Uterus (50) (10)
Hemangiosarcoma 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 8 (16%) 2 (20%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
Cervix, Adenocarcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10)
Lymph Node (50) (10)
Lymph Node, Mandibular (50) (10)
Lymph Node, Mesenteric (47) (10)
Spleen (50) (10)
Thymus (48) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10)
Carcinoma 1 (2%)
Fibroadenoma 8 (16%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (10)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10)
Alveolar/Bronchiolar Adenoma 3 (6%)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5)
Harderian Gland (2)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10)
Urinary Bladder (50) (10)
Transitional Epithelium, Carcinoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10)
Leukemia Mononuclear 26 (52%) 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 4
Total Primary Neoplasms 95 6
Total Animals with Benign Neoplasms 35 2
Total Benign Neoplasms 57 4
Total Animals with Malignant Neoplasms 32 2
Total Malignant Neoplasms 38 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10 50 10 50 10
Scheduled Sacrifice 10 10 10
Early Deaths
Natural Death 2 3 2
Moribund Sacrifice 16 13 24
Survivors
Terminal Sacrifice 32 34 24
Animals Examined Microscopically 50 10 50 10 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (10) (48) (49)
Intestine Large, Rectum (46) (10) (49) (50)
Intestine Small, Duodenum (49) (10) (47) (50)
Intestine Small, Ileum (48) (10) (47) (48)
Intestine Small, Jejunum (48) (10) (47) (48)
Liver (50) (10) (50) (10) (50) (10)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 3 (6%) 1 (2%)
Mesentery (10) (2) (11) (2) (5) (2)
Histiocytic Sarcoma 1 (10%)
Pancreas (49) (10) (49) (50) (1)
Histiocytic Sarcoma 1 (2%)
Acinar Cell, Adenoma 5 (10%) 3 (6%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Stomach, Forestomach (50) (10) (50) (50) (1)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (10) (49) (50) (1)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50) (1) (50)
Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (10) (50) (50)
Adenoma 2 (4%) 1 (2%)
Adrenal Gland, Medulla (49) (10) (50) (50)
Ganglioneuroma 1 (10%)
Pheochromocytoma Malignant 4 (8%) 3 (6%) 2 (4%)
Pheochromocytoma Benign 7 (14%) 5 (10%) 8 (16%)
Bilateral, Pheochromocytoma Malignant 2 (4%)
Bilateral, Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (49) (10) (49) (50)
Adenoma 1 (2%) 3 (6%) 4 (8%)
Adenoma, Multiple 1 (2%)
Mixed Tumor Benign 2 (4%)
Parathyroid Gland (47) (10) (46) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (10) (50) (1) (49)
Pars Distalis, Adenoma 14 (28%) 3 (30%) 11 (22%) 1 (100%) 9 (18%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (49) (10) (50) (50)
C-Cell, Adenoma 1 (2%) 2 (4%) 2 (4%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (10) (50) (10) (50) (10)
Preputial Gland (50) (10) (50) (10) (50) (9)
Adenoma 3 (6%) 1 (2%)
Carcinoma 6 (12%) 4 (8%) 1 (10%) 3 (6%) 1 (11%)
Squamous Cell Carcinoma 2 (4%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Prostate (50) (10) (50) (50)
Sarcoma 1 (2%)
Seminal Vesicle (50) (10) (50) (50) (1)
Testes (50) (10) (50) (10) (50) (10)
Bilateral, Interstitial Cell, Adenoma 40 (80%) 4 (40%) 38 (76%) 1 (10%) 36 (72%) 4 (40%)
Interstitial Cell, Adenoma 8 (16%) 1 (10%) 7 (14%) 5 (50%) 9 (18%) 5 (50%)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10) (50) (50)
Lymph Node (50) (10) (50) (50) (1)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Pancreatic, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (50) (10) (48) (50)
Lymph Node, Mesenteric (49) (10) (48) (49)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (10) (49) (10) (50) (10)
Hemangiosarcoma 1 (2%)
Thymus (45) (9) (48) (42)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (10) (49) (47)
Adenoma 1 (2%)
Fibroadenoma 3 (6%) 1 (2%) 2 (4%)
Skin (50) (10) (50) (1) (50)
Basal Cell Adenoma 1 (2%)
Basosquamous Tumor Benign 1 (2%)
Hemangioma 1 (2%)
Keratoacanthoma 3 (6%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Basal Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (6%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
Subcutaneous Tissue, Scrotum, Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50) (50)
Cranium, Osteoma 1 (2%)
Femur, Chondroma 1 (2%)
Tibia, Chondroma 1 (2%)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50) (50)
Astrocytoma Malignant 1 (2%)
Glioma Malignant 1 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10) (50) (1) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (10%) 1 (100%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Pheochromocytoma Malignant, Multiple,
Metastatic, Adrenal Gland 1 (2%)
Nose (50) (10) (50) (50)
Lumen, Endothelium, Squamous Cell Carcinoma 1 (2%)
Respiratory Epithelium, Squamous Cell
Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Pinna, Schwannoma Malignant 1 (100%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (10) (50) (10) (50) (10)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (50) (10) (50) (10) (50) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10) *(50) *(10) *(50) *(10)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 26 (52%) 25 (50%) 1 (10%) 42 (84%)
Mesothelioma Malignant 1 (2%) 1 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 14
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.0% 0.0222% 0.0222% 0.0666% 0.0666%
15 SSAC 15 SSAC 15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 8 49 7 50 9
Total Primary Neoplasms 147 12 133 11 140 10
Total Animals with Benign Neoplasms 50 8 48 6 47 9
Total Benign Neoplasms 96 10 90 8 85 9
Total Animals with Malignant Neoplasms 35 2 33 2 45 1
Total Malignant Neoplasms 51 2 43 3 55 1
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 15
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 10
Scheduled Sacrifice 9
Early Deaths
Moribund Sacrifice 35 1
Natural Death 6
Survivors
Natural Death 1
Terminal Sacrifice 8
Animals Examined Microscopically 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (10)
Intestine Large, Colon (48) (10)
Intestine Small, Duodenum (47) (10)
Intestine Small, Ileum (46) (10)
Intestine Small, Jejunum (48) (10)
Adenocarcinoma 1 (2%)
Liver (50) (10)
Hepatocellular Adenoma 1 (2%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (9)
Pancreas (48) (10)
Carcinoma, Metastatic 1 (2%)
Acinar Cell, Adenoma 5 (10%)
Stomach, Forestomach (50) (10)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (10)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (10)
Adrenal Gland, Medulla (49) (10)
Pheochromocytoma Benign 9 (18%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Page 16
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (48) (10)
Adenoma 2 (4%)
Mixed Tumor Benign 1 (2%)
Parathyroid Gland (48) (10)
Adenoma 1 (2%)
Pituitary Gland (49) (10)
Pars Distalis, Adenoma 4 (8%)
Thyroid Gland (50) (10)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (10)
Preputial Gland (49) (10)
Adenoma 1 (2%)
Carcinoma 8 (16%) 1 (10%)
Prostate (50) (10)
Seminal Vesicle (50) (10)
Testes (50) (10)
Bilateral, Interstitial Cell, Adenoma 35 (70%) 4 (40%)
Interstitial Cell, Adenoma 10 (20%) 3 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10)
Lymph Node (50) (10)
Lymph Node, Mandibular (50) (10)
Lymph Node, Mesenteric (48) (10)
Spleen (50) (10)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hemangiosarcoma 2 (4%)
Sarcoma 1 (2%)
Thymus (47) (10)
____________________________________________________________________________________________________________________________________
Page 17
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (10)
Fibroadenoma 1 (2%)
Skin (50) (10)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 2 (4%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Myxosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10)
Skeletal Muscle (2)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10)
Glioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (10)
Nose (50) (10)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Harderian Gland (2)
Carcinoma 1 (50%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (10)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 2 (4%)
Urinary Bladder (50) (10)
Page 18
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(10)
Leukemia Mononuclear 34 (68%) 2 (20%)
Mesothelioma Malignant 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 19
NTP Experiment-Test: 05092-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC O-NITROANISOLE Date: 09/12/94
Route: DOSED FEED Time: 15:57:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.200% 0.200%
15 SSAC
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 8
Total Primary Neoplasms 137 10
Total Animals with Benign Neoplasms 48 7
Total Benign Neoplasms 78 7
Total Animals with Malignant Neoplasms 44 3
Total Malignant Neoplasms 59 3
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 20
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