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TDMS Study 05092-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           O-NITROANISOLE


NTP Experiment-Test: 05092-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: DOSED FEED                                                                                                 Time: 15:57:55




       Facility:  Southern Research Institute

       Chemical CAS #:  0091-23-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           50           10           50           10           
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17                         7                        18                        
    Natural Death                                                                2                         6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                        41                        26                        
  Animals Examined Microscopically                    50           10           50           10           50           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (10)         (49)                      (46)                      
   Intestine Large, Colon                             (50)         (10)         (49)                      (46)                      
   Intestine Large, Rectum                            (50)         (10)         (49)                      (46)                      
   Intestine Small, Ileum                             (50)         (10)         (49)                      (46)                      
   Intestine Small, Jejunum                           (50)         (10)         (49)                      (47)                      
   Liver                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Sarcoma Stromal, Metastatic, Uterus                                                                  1 (2%)                   
   Mesentery                                          (9)          (1)          (6)          (2)          (11)                      
      Hemangiosarcoma                                                            1 (17%)                                            
      Fat, Fibrosarcoma                                1 (11%)                                                                      
      Fat, Lipoma                                                                1 (17%)                                            
      Fat, Sarcoma Stromal, Metastatic, Uterus                                                             1 (9%)                   
   Pancreas                                           (50)         (10)         (50)                      (49)                      
   Pharynx                                                                                                (2)                       
      Palate, Squamous Cell Carcinoma                                                                      1 (50%)                  
   Stomach, Forestomach                               (50)         (10)         (50)         (1)          (50)                      
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (10)         (50)         (1)          (50)                      
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                      (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (50)                      (50)                      
      Adenoma                                          1 (2%)                    5 (10%)                                            
   Adrenal Gland, Medulla                             (50)         (10)         (50)                      (50)                      
      Pheochromocytoma Malignant                                                                           1 (2%)                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (10)         (50)                      (49)                      
      Adenoma                                          2 (4%)                    1 (2%)                    2 (4%)                   
      Carcinoma                                                                                            1 (2%)                   
   Pituitary Gland                                    (50)         (10)         (50)         (3)          (50)         (1)          
      Pars Distalis, Adenoma                          28 (56%)                  28 (56%)      2 (67%)     27 (54%)      1 (100%)    
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)         (50)                      (50)         (1)          
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  4 (8%)                    3 (6%)                    2 (4%)                   
      C-Cell, Adenoma, Multiple                                                  1 (2%)                                             
      C-Cell, Carcinoma                                2 (4%)                    2 (4%)                    1 (2%)       1 (100%)    
      Follicular Cell, Adenoma                                                                             1 (2%)                   
      Follicular Cell, Carcinoma                                                 2 (4%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (10)         (47)         (10)         (50)         (10)         
      Adenoma                                          3 (7%)                    5 (11%)                   3 (6%)       1 (10%)     
      Carcinoma                                        4 (9%)                    1 (2%)                    2 (4%)                   
      Bilateral, Carcinoma                                                                                 1 (2%)                   
   Ovary                                              (50)         (10)         (50)                      (50)                      
      Thecoma Benign                                                             1 (2%)                                             
   Uterus                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Hemangioma                                       1 (2%)                                                                       
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    9 (18%)      3 (30%)     13 (26%)                   8 (16%)                  
      Sarcoma Stromal                                                                                      3 (6%)                   
      Cervix, Leiomyoma                                1 (2%)                                                                       
      Cervix, Leiomyosarcoma                                                                               1 (2%)                   
   Vagina                                                                       (3)                       (1)                       
      Polyp                                                                                                1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)         (50)                      (50)                      
   Lymph Node                                         (50)         (10)         (50)                      (50)                      
   Lymph Node, Mandibular                             (48)         (10)         (49)                      (50)                      
   Lymph Node, Mesenteric                             (48)         (10)         (50)                      (50)                      
   Spleen                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (47)         (10)         (49)                      (47)                      
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)         (50)                      (50)                      
      Adenocarcinoma                                   2 (4%)                                              2 (4%)                   
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                    17 (34%)                  17 (34%)                  12 (24%)                  
      Fibroadenoma, Multiple                                                     1 (2%)                    3 (6%)                   
   Skin                                               (50)         (10)         (50)                      (50)                      
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                               2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                      (50)                      
      Maxilla, Squamous Cell Carcinoma, Metastatic,                                                                                 
           Nose                                        1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                 (1)                       
      Abdominal, Lipoma                                                                                    1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                      (50)                      
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Sarcoma                                                                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (50)                      (50)         (1)          
      Alveolar/Bronchiolar Adenoma                                                                         2 (4%)       1 (100%)    
   Nose                                               (50)         (10)         (50)         (3)          (50)         (6)          
      Respiratory Epithelium, Squamous Cell                                                                                         
          Carcinoma                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                                                 (1)          
      Pinna, Schwannoma Malignant                                                                                       1 (100%)    
   Zymbal's Gland                                     (1)                       (1)                                                 
      Carcinoma                                        1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Myxosarcoma                                                                                          1 (2%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(50)        *(10)        *(50)        *(10)         
      Leukemia Mononuclear                            14 (28%)                  11 (22%)                  14 (28%)      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                15 SSAC                   15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46           3          46           2          46           5               
     Total Primary Neoplasms                           99           3         101           2          93           6               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40           3          44           2          38           3               
     Total Benign Neoplasms                            73           3          80           2          62           3               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21                      18                      27           3               
     Total Malignant Neoplasms                         26                      21                      31           3               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                               1                           
     Total Metastatic Neoplasm                          2                                               2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10                                                               
  Scheduled Sacrifice                                               9                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14            1                                                               
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                                                                            
  Animals Examined Microscopically                    50           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (10)                                                             
   Intestine Small, Jejunum                           (48)         (10)                                                             
   Liver                                              (50)         (10)                                                             
      Hepatocellular Adenoma                           3 (6%)                                                                       
   Mesentery                                          (12)         (4)                                                              
   Pancreas                                           (50)         (10)                                                             
      Acinar Cell, Adenoma                             1 (2%)                                                                       
      Acinar Cell, Adenoma, Multiple                   1 (2%)                                                                       
   Salivary Glands                                    (50)         (10)                                                             
   Stomach, Forestomach                               (50)         (10)                                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)                                                             
      Adenoma                                          2 (4%)                                                                       
   Adrenal Gland, Medulla                             (49)         (10)                                                             
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (10)                                                             
      Pars Distalis, Adenoma                          19 (38%)                                                                      
      Pars Distalis, Adenoma, Multiple                              1 (10%)                                                         
   Thyroid Gland                                      (50)         (10)                                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                  3 (6%)       1 (10%)                                                         
      C-Cell, Carcinoma                                1 (2%)       1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (10)                                                             
      Adenoma                                          3 (6%)                                                                       
      Carcinoma                                        2 (4%)                                                                       
   Ovary                                              (50)         (10)                                                             
   Uterus                                             (50)         (10)                                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Stromal                                    8 (16%)      2 (20%)                                                         
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                  1 (2%)                                                                       
      Cervix, Adenocarcinoma                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)                                                             
   Lymph Node                                         (50)         (10)                                                             
   Lymph Node, Mandibular                             (50)         (10)                                                             
   Lymph Node, Mesenteric                             (47)         (10)                                                             
   Spleen                                             (50)         (10)                                                             
   Thymus                                             (48)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)                                                             
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                     8 (16%)                                                                      
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)                                                             
      Alveolar/Bronchiolar Adenoma                     3 (6%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)                                                                           
   Harderian Gland                                    (2)                                                                           
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)                                                             
   Urinary Bladder                                    (50)         (10)                                                             
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)                                                             
      Leukemia Mononuclear                            26 (52%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46           4                                                               
     Total Primary Neoplasms                           95           6                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 35           2                                                               
     Total Benign Neoplasms                            57           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32           2                                                               
     Total Malignant Neoplasms                         38           2                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           50           10           50           10           
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
    Natural Death                                      2                         3                         2                        
    Moribund Sacrifice                                16                        13                        24                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                32                        34                        24                        
  Animals Examined Microscopically                    50           10           50           10           50           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (10)         (48)                      (49)                      
   Intestine Large, Rectum                            (46)         (10)         (49)                      (50)                      
   Intestine Small, Duodenum                          (49)         (10)         (47)                      (50)                      
   Intestine Small, Ileum                             (48)         (10)         (47)                      (48)                      
   Intestine Small, Jejunum                           (48)         (10)         (47)                      (48)                      
   Liver                                              (50)         (10)         (50)         (10)         (50)         (10)         
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                                                     3 (6%)                    1 (2%)                   
   Mesentery                                          (10)         (2)          (11)         (2)          (5)          (2)          
      Histiocytic Sarcoma                              1 (10%)                                                                      
   Pancreas                                           (49)         (10)         (49)                      (50)         (1)          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Acinar Cell, Adenoma                             5 (10%)                   3 (6%)                                             
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Stomach, Forestomach                               (50)         (10)         (50)                      (50)         (1)          
      Squamous Cell Carcinoma                                                                              1 (2%)                   
      Squamous Cell Papilloma                                                                              1 (2%)                   
   Stomach, Glandular                                 (50)         (10)         (49)                      (50)         (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)         (1)          (50)                      
      Schwannoma Benign                                                                                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (10)         (50)                      (50)                      
      Adenoma                                          2 (4%)                                              1 (2%)                   
   Adrenal Gland, Medulla                             (49)         (10)         (50)                      (50)                      
      Ganglioneuroma                                                1 (10%)                                                         
      Pheochromocytoma Malignant                       4 (8%)                    3 (6%)                    2 (4%)                   
      Pheochromocytoma Benign                          7 (14%)                   5 (10%)                   8 (16%)                  
      Bilateral, Pheochromocytoma Malignant            2 (4%)                                                                       
      Bilateral, Pheochromocytoma Benign                                         2 (4%)                                             
   Islets, Pancreatic                                 (49)         (10)         (49)                      (50)                      
      Adenoma                                          1 (2%)                    3 (6%)                    4 (8%)                   
      Adenoma, Multiple                                                          1 (2%)                                             
      Mixed Tumor Benign                                                                                   2 (4%)                   
   Parathyroid Gland                                  (47)         (10)         (46)                      (47)                      
      Adenoma                                                                                              1 (2%)                   
   Pituitary Gland                                    (50)         (10)         (50)         (1)          (49)                      
      Pars Distalis, Adenoma                          14 (28%)      3 (30%)     11 (22%)      1 (100%)     9 (18%)                  
      Pars Distalis, Carcinoma                         1 (2%)                                              1 (2%)                   
   Thyroid Gland                                      (49)         (10)         (50)                      (50)                      
      C-Cell, Adenoma                                  1 (2%)                    2 (4%)                    2 (4%)                   
      C-Cell, Carcinoma                                1 (2%)                    2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)         (50)         (10)         (50)         (10)         
   Preputial Gland                                    (50)         (10)         (50)         (10)         (50)         (9)          
      Adenoma                                          3 (6%)                                              1 (2%)                   
      Carcinoma                                        6 (12%)                   4 (8%)       1 (10%)      3 (6%)       1 (11%)     
      Squamous Cell Carcinoma                          2 (4%)                                                                       
      Bilateral, Adenoma                               1 (2%)                                                                       
      Bilateral, Carcinoma                             1 (2%)                                                                       
   Prostate                                           (50)         (10)         (50)                      (50)                      
      Sarcoma                                                                    1 (2%)                                             
   Seminal Vesicle                                    (50)         (10)         (50)                      (50)         (1)          
   Testes                                             (50)         (10)         (50)         (10)         (50)         (10)         
      Bilateral, Interstitial Cell, Adenoma           40 (80%)      4 (40%)     38 (76%)      1 (10%)     36 (72%)      4 (40%)     
      Interstitial Cell, Adenoma                       8 (16%)      1 (10%)      7 (14%)      5 (50%)      9 (18%)      5 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)         (50)                      (50)                      
   Lymph Node                                         (50)         (10)         (50)                      (50)         (1)          
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
      Pancreatic, Histiocytic Sarcoma                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (10)         (48)                      (50)                      
   Lymph Node, Mesenteric                             (49)         (10)         (48)                      (49)                      
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (10)         (49)         (10)         (50)         (10)         
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (45)         (9)          (48)                      (42)                      
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (10)         (49)                      (47)                      
      Adenoma                                                                    1 (2%)                                             
      Fibroadenoma                                     3 (6%)                    1 (2%)                    2 (4%)                   
   Skin                                               (50)         (10)         (50)         (1)          (50)                      
      Basal Cell Adenoma                               1 (2%)                                                                       
      Basosquamous Tumor Benign                                                  1 (2%)                                             
      Hemangioma                                       1 (2%)                                                                       
      Keratoacanthoma                                  3 (6%)                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                    1 (2%)                   
      Sebaceous Gland, Carcinoma                                                 1 (2%)                                             
      Subcutaneous Tissue, Basal Cell Carcinoma        1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                    3 (6%)                    2 (4%)                   
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
      Subcutaneous Tissue, Scrotum, Fibrosarcoma                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                      (50)                      
      Cranium, Osteoma                                                                                     1 (2%)                   
      Femur, Chondroma                                                           1 (2%)                                             
      Tibia, Chondroma                                                           1 (2%)                                             
   Skeletal Muscle                                                 (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  13                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                      (50)                      
      Astrocytoma Malignant                            1 (2%)                                                                       
      Glioma Malignant                                              1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (50)         (1)          (50)                      
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    2 (4%)                    2 (4%)                   
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (10%)                   1 (100%)                              
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                    1 (2%)                   
      Carcinoma, Metastatic, Thyroid Gland                                                                 1 (2%)                   
      Pheochromocytoma Malignant, Multiple,                                                                                         
          Metastatic, Adrenal Gland                    1 (2%)                                                                       
   Nose                                               (50)         (10)         (50)                      (50)                      
      Lumen, Endothelium, Squamous Cell Carcinoma      1 (2%)                                                                       
      Respiratory Epithelium, Squamous Cell                                                                                         
          Carcinoma                                                              1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                                    (1)                       
      Pinna, Schwannoma Malignant                                                                          1 (100%)                 
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (10)         (50)         (10)         (50)         (10)         
      Renal Tubule, Adenoma                                                      1 (2%)                    1 (2%)                   
   Urinary Bladder                                    (50)         (10)         (50)         (10)         (50)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(50)        *(10)        *(50)        *(10)         
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            26 (52%)                  25 (50%)      1 (10%)     42 (84%)                  
      Mesothelioma Malignant                           1 (2%)       1 (10%)                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.0%         0.0222%      0.0222%      0.0666%      0.0666%         
                                                                 15 SSAC                  15 SSAC                   15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50           8          49           7          50           9               
     Total Primary Neoplasms                          147          12         133          11         140          10               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50           8          48           6          47           9               
     Total Benign Neoplasms                            96          10          90           8          85           9               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35           2          33           2          45           1               
     Total Malignant Neoplasms                         51           2          43           3          55           1               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                               1                           
     Total Metastatic Neoplasm                          1                                               1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10                                                               
  Scheduled Sacrifice                                               9                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                35            1                                                               
    Natural Death                                      6                                                                            
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                 8                                                                            
  Animals Examined Microscopically                    50           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (10)                                                             
   Intestine Large, Colon                             (48)         (10)                                                             
   Intestine Small, Duodenum                          (47)         (10)                                                             
   Intestine Small, Ileum                             (46)         (10)                                                             
   Intestine Small, Jejunum                           (48)         (10)                                                             
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (10)                                                             
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
   Mesentery                                          (9)                                                                           
   Pancreas                                           (48)         (10)                                                             
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Acinar Cell, Adenoma                             5 (10%)                                                                      
   Stomach, Forestomach                               (50)         (10)                                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (10)                                                             
   Adrenal Gland, Medulla                             (49)         (10)                                                             
      Pheochromocytoma Benign                          9 (18%)                                                                      
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
                                                             Page  16                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (48)         (10)                                                             
      Adenoma                                          2 (4%)                                                                       
      Mixed Tumor Benign                               1 (2%)                                                                       
   Parathyroid Gland                                  (48)         (10)                                                             
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (10)                                                             
      Pars Distalis, Adenoma                           4 (8%)                                                                       
   Thyroid Gland                                      (50)         (10)                                                             
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)                                                             
   Preputial Gland                                    (49)         (10)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        8 (16%)      1 (10%)                                                         
   Prostate                                           (50)         (10)                                                             
   Seminal Vesicle                                    (50)         (10)                                                             
   Testes                                             (50)         (10)                                                             
      Bilateral, Interstitial Cell, Adenoma           35 (70%)      4 (40%)                                                         
      Interstitial Cell, Adenoma                      10 (20%)      3 (30%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)                                                             
   Lymph Node                                         (50)         (10)                                                             
   Lymph Node, Mandibular                             (50)         (10)                                                             
   Lymph Node, Mesenteric                             (48)         (10)                                                             
   Spleen                                             (50)         (10)                                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hemangiosarcoma                                  2 (4%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (47)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  17                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (10)                                                             
      Fibroadenoma                                     1 (2%)                                                                       
   Skin                                               (50)         (10)                                                             
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                  2 (4%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Myxosarcoma                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)                                                             
   Skeletal Muscle                                    (2)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)                                                             
      Glioma Malignant                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)                                                             
   Nose                                               (50)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                                                                           
   Harderian Gland                                    (2)                                                                           
      Carcinoma                                        1 (50%)                                                                      
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (10)                                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                          2 (4%)                                                                       
   Urinary Bladder                                    (50)         (10)                                                             
                                                             Page  18                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)                                                             
      Leukemia Mononuclear                            34 (68%)      2 (20%)                                                         
      Mesothelioma Malignant                           3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  19                                                               
NTP Experiment-Test: 05092-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 15:57:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.200%       0.200%                                                              
                                                                15 SSAC                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50           8                                                               
     Total Primary Neoplasms                          137          10                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48           7                                                               
     Total Benign Neoplasms                            78           7                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              44           3                                                               
     Total Malignant Neoplasms                         59           3                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  20                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------