TDMS Study 05092-01 Pathology Tables
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
Facility: Southern Research Institute
Chemical CAS #: 0091-23-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|
| 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Clear Cell Focus | 2 3 2 |
Clear Cell Focus, Multiple | |
Cytomegaly | 3 |
Eosinophilic Focus | 2 |
Eosinophilic Focus, Multiple | 3 3 3 2 |
Hepatodiaphragmatic Nodule | 2 X|
Hyperplasia, Nodular | 3 2 |
Inflammation, Granulomatous, Multiple| 2 2 2 2 1 2 1 1 1 1 2 2 3 1 1 2 1 2|
Karyomegaly | 3 |
Mixed Cell Focus | 2|
Vacuolization Cytoplasmic | 2 4 4 4 2 |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 2 2 2 2 2 2 1|
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Focal, | |
Granulomatous | 3 3 |
Fat, Necrosis, Focal | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Acinar Cell, Atrophy | 2 2 2 4 3 2 2 2 |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 |
Acinar Cell, Atrophy | 3 |
Acinar Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|
| 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 3 |
Ulcer | 4 |
Ulcer, Multiple | |
Epithelium, Hyperplasia | 2 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion, Multiple | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 3 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 2 2 |
Hyperplasia, Focal | 2 2 2 1 |
Hypertrophy, Focal | 2 2 2 2 |
Vacuolization Cytoplasmic, Focal | 2 2 1 2 2 2 2 |
Vacuolization Cytoplasmic | 2 |
Bilateral, Hypertrophy, Focal | 2 |
Bilateral, Vacuolization Cytoplasmic | 3 |
Spindle Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst, Multiple | 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia, Focal | 2 2 2 |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|
| 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + M + + M + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | |
Cyst | X 3 2 3 3 3 2 3|
Cyst, Multiple | 3 |
Hyperplasia, Focal | |
Hyperplasia | 3 2 3 3 2 2|
Inflammation, Suppurative | 2|
Bilateral, Cyst | 3 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Bilateral, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Glandular | 2 |
Inflammation, Suppurative | |
Cervix, Cyst | 2 |
Cervix, Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + M + + + + + + + + + + + + +|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Angiectasis | 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst, Multiple | 2 2 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 3 |
Hematopoietic Cell Proliferation | 2 |
Pigmentation | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + M + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2 2 3 3 2 2 2 2 2 2 2 |
Duct, Cyst | 2 3 2 2 2 2 2 2 2 2 4 3 3 X 4 3|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|
| 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 4 3 |
Calvarium, Hyperostosis | 2 3 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 3 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 3 |
Edema | |
Infiltration Cellular, Focal, | |
Histiocyte | |
Infiltration Cellular, Multiple, | |
Histiocyte | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Focal, Granulomatous | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | 3 3 |
Lumen, Inflammation, Suppurative | 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Submucosa, Pigmentation | 1 1 2 2 1 1 2 2 2 1 2 1 1 2 2 2 2 2 1 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | 3 |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Inflammation, Chronic | 2 |
Nephropathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 3 2|
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| |
| 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 | 2 1.5|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2| 37 1.9|
Clear Cell Focus | 3 3 | 5 2.6|
Clear Cell Focus, Multiple | 2 | 1 2.0|
Cytomegaly | | 1 3.0|
Eosinophilic Focus | 2 2 | 3 2.0|
Eosinophilic Focus, Multiple | 3 | 5 2.8|
Hepatodiaphragmatic Nodule | 3 X | 4 2.5|
Hyperplasia, Nodular | 3 3 | 4 2.8|
Inflammation, Granulomatous, Multiple| 2 2 2 1 2 2 1 2 2 2 1 2 2 2 2 2 2 1| 36 1.7|
Karyomegaly | | 1 3.0|
Mixed Cell Focus | 2 | 2 2.0|
Vacuolization Cytoplasmic | 3 4 3 3 2 | 10 3.1|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 2 1 2 2 3 1 2 1 2 | 29 1.6|
Centrilobular, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Inflammation, Focal, | | |
Granulomatous | | 2 3.0|
Fat, Necrosis, Focal | 3 2 2 3 | 7 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2 | 3 2.3|
Acinar Cell, Atrophy | 2 2 2 2 2 2| 14 2.2|
Acinar Cell, Hyperplasia | 2 3 2 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| |
| 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Atrophy | | 1 3.0|
Acinar Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 2 3 | 4 3.0|
Inflammation, Chronic | 2 3 | 4 2.8|
Ulcer | | 1 4.0|
Ulcer, Multiple | 4 3 | 2 3.5|
Epithelium, Hyperplasia | 3 2 3 2 2 | 8 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Erosion, Multiple | 2 | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 2 3 1 2 2 2 2 2 2 2 2 | 34 2.1|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 X | 6 2.0|
Hyperplasia, Focal | | 4 1.8|
Hypertrophy, Focal | 2 2 2 | 7 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 2 2 1 2 1| 14 1.8|
Vacuolization Cytoplasmic | | 1 2.0|
Bilateral, Hypertrophy, Focal | | 1 2.0|
Bilateral, Vacuolization Cytoplasmic | | 1 3.0|
Spindle Cell, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 3 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 3 2 | 4 2.3|
Pars Distalis, Cyst, Multiple | 2 2 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| |
| 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | 3 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia, Focal | 2 2 2 3 2 2 | 9 2.1|
C-Cell, Hyperplasia | 2 2 2 | 5 2.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + M + + + + + + + + + + + + + + + + + +| 45 |
Abscess | | 1 4.0|
Atrophy | 3 | 1 3.0|
Cyst | 2 3 3 2 2 3 | 14 2.6|
Cyst, Multiple | | 1 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 2 3 | 8 2.5|
Inflammation, Suppurative | 3 | 2 2.5|
Bilateral, Cyst | 2 3 2 3 | 7 2.6|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 | 5 2.4|
Bilateral, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 3 | 2 2.5|
Hyperplasia, Glandular | 2 | 2 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Cervix, Cyst | 4 | 2 3.0|
Cervix, Inflammation, Suppurative | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 3 2 2 2 | 7 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3| 1 3.0|
Mediastinal, Angiectasis | 3 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| |
| 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst, Multiple | 2 | 3 2.0|
Hyperplasia, Lymphoid | 2 2 2 3 3 | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 2 2.5|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Pigmentation | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 3 2 2 3 2 2 2 2 | 19 2.2|
Duct, Cyst | 2 3 2 2 2 3 3 3 3 3 2 3 2 2 2 3 2 3 3 2 3 3| 38 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 2 3.5|
Calvarium, Hyperostosis | 2 2 2| 6 2.2|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 4 3 | 10 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis | | 1 3.0|
Edema | 3 | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 | 1 2.0|
Infiltration Cellular, Multiple, | | |
Histiocyte | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 | 2 2.0|
Inflammation, Focal, Granulomatous | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Fungus | 2 3| 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| |
| 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
0.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lumen, Inflammation, Suppurative | 2 2| 4 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Submucosa, Pigmentation | 1 1 2 1 1 1 2 1 2 2 1 2 1 2 2 2 2 1 2 2 2 2 2 2| 46 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Nephropathy, Chronic | 2 3 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 39 2.1|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | 41 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
Parasite Metazoan | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 | 2 1.0|
Basophilic Focus, Multiple | 1 2 2 1 1 1 2 | 7 1.4|
Inflammation, Granulomatous, Multiple| 1 1 2 1 1 | 5 1.2|
Mixed Cell Focus | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
Spindle Cell, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
Cyst | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Cyst | 2 | 1 2.0|
Bilateral, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 2 3 | 2 2.5|
Endometrium, Hyperplasia, Cystic | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
Calvarium, Hyperostosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Submucosa, Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
0.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Inflammation, Chronic, Focal | 3 | 1 3.0|
Nephropathy, Chronic | 1 1 2 | 3 1.3|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|
| 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Wall, Foreign Body | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 |
Basophilic Focus, Multiple | 2 2 2 1 2 2 2 2 2 2 2 2 1 2|
Clear Cell Focus | 2 |
Clear Cell Focus, Multiple | 1 2 |
Eosinophilic Focus | 2 2 2 2 2|
Eosinophilic Focus, Multiple | 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 3 |
Hyperplasia, Nodular | 3 2 3 2 3 3 |
Inflammation, Granulomatous, Multiple| 2 2 1 2 2 2 1 2 2 1 1 2|
Mixed Cell Focus | 3 1 1 |
Vacuolization Cytoplasmic | 2 2 3 |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 1 2 2 1 2 2 2 1 2 2 2 2 1 1 1|
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 |
Vein, Thrombosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | |
Fat, Inflammation, Focal, | |
Granulomatous | 3 |
Fat, Necrosis, Focal | 2 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | 2 2 |
Ectopic Tissue | |
Acinar Cell, Atrophy | 2 2 3 2 2 2 2 |
Acinar Cell, Hyperplasia | 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|
| 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | |
Acinar Cell, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Inflammation, Chronic | 3 3|
Ulcer | 2 2 |
Ulcer, Multiple | 3 |
Epithelium, Hyperplasia | 2 2 2 3 1 2 3 2 2 3 1 2 2 2 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 2 |
Cyst | |
Degeneration, Cystic | 4 2 |
Hyperplasia, Focal | 2 2 2 2 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 2 2 2|
Bilateral, Hyperplasia | 2 |
Bilateral, Vacuolization Cytoplasmic,| |
Focal | |
Bilateral, Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 3 2 |
Pars Distalis, Cyst, Multiple | 2 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 3 2 2 2 |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 2|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|
| 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | 2 2 3 3 2 2 3 |
Hyperplasia | 3 2|
Inflammation, Suppurative | |
Bilateral, Cyst | 3 2 3 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 4 2 |
Cyst, Multiple | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 |
Fibrosis, Focal | |
Hemorrhage | 4 |
Hyperplasia, Glandular | 3 3 |
Cervix, Hemorrhage | |
Cervix, Myometrium, Hyperplasia | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 3 3|
Vein, Thrombosis | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 2 3|
Mediastinal, Congestion | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 3|
Pancreatic, Angiectasis | 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + M + + +|
Angiectasis | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
Inflammation, Granulomatous | |
Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|
| 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Congestion | |
Cyst | 3 |
Hyperplasia, Lymphoid | 3 |
Mediastinum, Edema | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 3 2 2 3 2 3 3 2 2 2 2 2 2 2 2|
Duct, Cyst | 2 2 2 3 2 2 3 2 2 2 2 2 4 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
Calvarium, Hyperostosis | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 |
Hemorrhage, Multiple | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Focal, | |
Histiocyte | |
Infiltration Cellular, Multiple, | |
Histiocyte | |
Inflammation, Focal, Granulomatous | 3 2 |
Inflammation, Granulomatous, Multiple| 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Pigmentation | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | |
Lumen, Inflammation, Suppurative | |
Submucosa, Pigmentation | 2 2 1 2 2 2 1 2 2 2 1 1 1 2 2 1 2 2 2 1 1 2 3 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|
| 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 2 4 |
Inflammation, Suppurative | |
Retina, Degeneration | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 3 3 3 2 2 3 2 2 2 2 2 3 2 3 3 3 2 2 3 2 3|
Renal Tubule, Dilatation | |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 1 1 1 2 1 3 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Chronic | 1 |
Transitional Epithelium, Hyperplasia | 2 2 4 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3| |
| 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
0.200% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Wall, Foreign Body | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Inflammation, Granulomatous | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 1| 3 1.3|
Basophilic Focus, Multiple | 2 2 2 2 1 2 2 2 2 2 1 3 | 26 1.9|
Clear Cell Focus | 1 2 | 3 1.7|
Clear Cell Focus, Multiple | | 2 1.5|
Eosinophilic Focus | 2 3 2 1| 9 2.0|
Eosinophilic Focus, Multiple | 2 3 | 5 2.2|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | 2 2 3 2 3 2| 8 2.5|
Hyperplasia, Nodular | 3 3 3 3 3 3 2 3 | 14 2.8|
Inflammation, Granulomatous, Multiple| 2 1 1 1 2 2 1 1 1| 21 1.5|
Mixed Cell Focus | 2 2 | 5 1.8|
Vacuolization Cytoplasmic | 4 4 | 5 3.0|
Bile Duct, Hyperplasia | 2 2 1 2 2 1 2 2 2 1 2 3 2 2 1 2 2 2 2 1 1 1 | 43 1.7|
Centrilobular, Necrosis | 3 | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 2.0|
Vein, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 12 |
Inflammation, Chronic | 4 | 1 4.0|
Fat, Inflammation, Focal, | | |
Granulomatous | | 1 3.0|
Fat, Necrosis, Focal | 3 2 3 3 3| 10 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3| |
| 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
0.200% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | | 2 2.0|
Ectopic Tissue | 3 | 1 3.0|
Acinar Cell, Atrophy | 2 3 4 2 2 | 12 2.3|
Acinar Cell, Hyperplasia | 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinar Cell, Atrophy | 2 | 1 2.0|
Acinar Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 4 2| 5 2.8|
Inflammation, Chronic | 4 4 2 3| 6 3.2|
Ulcer | 3 3 4 3| 6 2.8|
Ulcer, Multiple | | 1 3.0|
Epithelium, Hyperplasia | 3 3 1 4 4 4 3 3 1 2 1 3 3| 28 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 2.0|
Ulcer | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 3 2 3 2 2 3 2 2 3 2 3 2 3 2 2 2| 39 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 2 2 2 | 7 2.0|
Cyst | 3 | 1 3.0|
Degeneration, Cystic | | 2 3.0|
Hyperplasia, Focal | 3 2 | 6 2.2|
Hypertrophy, Focal | 1 2 2 2 | 5 1.8|
Vacuolization Cytoplasmic, Focal | 2 2 2 1| 11 1.9|
Bilateral, Hyperplasia | | 1 2.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Focal | 2 | 1 2.0|
Bilateral, Vacuolization Cytoplasmic | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + + + + + + M + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3| |
| 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
0.200% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | 2 2 | 5 2.2|
Pars Distalis, Cyst, Multiple | 2 2 | 6 2.0|
Pars Distalis, Hyperplasia, Focal | | 7 2.3|
Pars Distalis, Hyperplasia | 2 3 3 3 | 4 2.8|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 | 5 2.0|
C-Cell, Hyperplasia | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Cyst | 3 3 3 3 3 3 3 2 | 15 2.7|
Hyperplasia | 2 3 3 2 | 6 2.5|
Inflammation, Suppurative | 3 3 | 2 3.0|
Bilateral, Cyst | 3 3 2 3 3 3 2 | 11 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 5 2.8|
Cyst, Multiple | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 3| 4 2.8|
Fibrosis, Focal | 2 | 1 2.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Glandular | 2 2 3 | 5 2.6|
Cervix, Hemorrhage | 4 | 1 4.0|
Cervix, Myometrium, Hyperplasia | 3 3 | 3 3.0|
Endometrium, Hyperplasia, Cystic | 2 3 2 2 2 2 | 12 2.3|
Vein, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + + + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | 2 3 3 | 6 2.7|
Mediastinal, Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3| |
| 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
0.200% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Mediastinal, Pigmentation | 3 | 2 3.0|
Pancreatic, Angiectasis | 2 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | | 1 3.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 4 | 3 3.7|
Inflammation, Granulomatous | 3 | 1 3.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Congestion | 2 | 1 2.0|
Cyst | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Mediastinum, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 3 3 3 2 2 3 | 21 2.4|
Duct, Cyst | 2 2 3 2 3 2 4 3 2 3 3 3 2 2 2 3 3 3 3| 34 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 | 1 3.0|
Epidermis, Hyperplasia | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 3.0|
Calvarium, Hyperostosis | 2 3 2| 5 2.2|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3| |
| 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
0.200% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 4 3| 6 2.8|
Hemorrhage, Multiple | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 2 | 2 2.0|
Infiltration Cellular, Multiple, | | |
Histiocyte | 3 3 | 2 3.0|
Inflammation, Focal, Granulomatous | 2 3 | 4 2.5|
Inflammation, Granulomatous, Multiple| | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 | 2 3.0|
Alveolus, Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Fungus | 2 | 1 2.0|
Lumen, Inflammation, Suppurative | 2 | 1 2.0|
Submucosa, Pigmentation | 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2| 50 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cataract | 3 | 4 2.8|
Inflammation, Suppurative | 3 | 1 3.0|
Retina, Degeneration | 3 | 4 3.8|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 3 2 2 2 2 3 4 2 2 3 3 2 2 3 2 2 2 2 2 3| 44 2.4|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Mineralization | 2 | 2 1.5|
Renal Tubule, Necrosis | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 3 2 2 2| 46 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3| |
| 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
0.200% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 1 2.0|
Inflammation, Chronic | 1 | 2 1.0|
Transitional Epithelium, Hyperplasia | 1 1 | 6 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| | |
| 6| 7| 7| 8| 8| 7| 6| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 | 2 1.0|
Basophilic Focus, Multiple | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | 3 | 1 3.0|
Inflammation, Granulomatous, Multiple| 1 1 1 1 1 | 5 1.0|
Mixed Cell Focus | 1 | 1 1.0|
Necrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 | 4 1.0|
Hepatocyte, Kupffer Cell, | | |
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 4 |
Fat, Inflammation, Focal, | | |
Granulomatous | 2 3 3 | 3 2.7|
Fat, Necrosis, Focal | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| | |
| 6| 7| 7| 8| 8| 7| 6| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Cyst, Multiple | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
Pars Intermedia, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
Cyst | 4 | 1 4.0|
Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| | |
| 6| 7| 7| 8| 8| 7| 6| 6| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.200% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Submucosa, Pigmentation | 2 1 1 1 1 1 1 1 2 2 | 10 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 2 1 2 | 4 1.8|
Renal Tubule, Dilatation | 2 2 2 2 1 2 1 2 | 8 1.8|
Renal Tubule, Mineralization | 2 1 1 2 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|
| 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0666% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + A + + + + A + + + + + + +|
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + A + + + + A + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + A + + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + A + + + + A + + + + + + +|
Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 1|
Clear Cell Focus | 1 2 |
Degeneration, Multiple | |
Eosinophilic Focus | 2 2 2 |
Eosinophilic Focus, Multiple | 3 2 |
Hepatodiaphragmatic Nodule | 2 2 2 2 |
Hyperplasia, Nodular | 2 |
Inflammation, Granulomatous, Multiple| 1 2 1 2 1 1 2 3 2 |
Mixed Cell Focus | 2 2 |
Necrosis | 4 |
Pigmentation | |
Vacuolization Cytoplasmic | 2 2 |
Bile Duct, Hyperplasia | 1 2 1 2 2 2 2 2 1 2 2 1 2 1 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Focal, | |
Granulomatous | |
Fat, Necrosis, Focal | 2 2 2 |
Fat, Necrosis, Focal, Multiple | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Basophilic Focus, Multiple | |
Acinar Cell, Atrophy | 2 2 2 2 2 2 |
Acinar Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Pharynx | + + |
Palate, Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | |
Infiltration Cellular, Lipocyte | 1 |
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|
| 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0666% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 2 2 |
Inflammation, Chronic | 4 3 |
Inflammation, Suppurative | 2 |
Ulcer | 1 |
Ulcer, Multiple | 3 3 |
Epithelium, Hyperplasia | 4 3 3 1 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Lymphoid | |
Mineralization | 2 |
Necrosis, Focal, Multiple | |
Ulcer, Multiple | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 |
Degeneration, Cystic | |
Hyperplasia, Focal | 2 3 2 |
Hyperplasia, Focal, Multiple | 2 |
Hypertrophy, Focal | 2 2 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 1 2 2 2|
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst, Multiple | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
Pars Intermedia, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia, Focal | 2 2 |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|
| 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0666% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 3 2 2 3 3 2 3 2 |
Hyperplasia, Focal | |
Hyperplasia | |
Inflammation, Suppurative | 2 |
Bilateral, Cyst | 3 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 4 |
Bilateral, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 |
Hyperplasia, Glandular | 3 |
Infiltration Cellular, Lipocyte | 3 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 3 4 2|
Mediastinal, Hemorrhage | 4 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 3 2 4 |
Necrosis | |
Pigmentation | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|
| 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0666% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2 3 2 2 2 2 2 2 3 2 2 |
Duct, Cyst | 2 3 2 3 2 2 2 3 2 2 2 3 2 2 3 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nipple, Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
Calvarium, Hyperostosis | 2 3 2 |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 4 3 3 2 |
Hemorrhage | 2 2 |
Hemorrhage, Multiple | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Focal, | |
Histiocyte | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | |
Lumen, Inflammation, Suppurative | |
Submucosa, Pigmentation | 2 2 2 2 1 1 1 2 2 2 1 1 2 2 2 1 2 2 2 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Multiple | 3 |
Nephropathy, Chronic | 2 3 3 3 2 3 2 2 1 2 2 3 2 3 2 2 2 2 2 2 3 3|
Pelvis, Dilatation | 2 |
Renal Tubule, Mineralization | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|
| 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.0666% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Pigmentation | 2 2 1 1 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2|
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3| |
| 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.0666% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 |
Parasite Metazoan | 2| 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 |
Parasite Metazoan | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 4 1.0|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1| 34 1.9|
Clear Cell Focus | 3 | 3 2.0|
Degeneration, Multiple | 3 | 1 3.0|
Eosinophilic Focus | 2 2 | 5 2.0|
Eosinophilic Focus, Multiple | 2 | 3 2.3|
Hepatodiaphragmatic Nodule | 2 3 2 3 3 2 | 10 2.3|
Hyperplasia, Nodular | 2 3 | 3 2.3|
Inflammation, Granulomatous, Multiple| 2 1 2 2 2 1 2 2 2 1 1 | 20 1.7|
Mixed Cell Focus | | 2 2.0|
Necrosis | 2 | 2 3.0|
Pigmentation | 2 | 1 2.0|
Vacuolization Cytoplasmic | 4 3 4 | 5 3.0|
Bile Duct, Hyperplasia | 2 2 1 2 1 2 1 2 2 2 2 2 2 1 1 2 1 2 2 | 34 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Fat, Inflammation, Focal, | | |
Granulomatous | 3 | 1 3.0|
Fat, Necrosis, Focal | 2 2 2 3 2 3 | 9 2.2|
Fat, Necrosis, Focal, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus, Multiple | 2 | 1 2.0|
Acinar Cell, Atrophy | 2 2 2 3 2 2 4 2 3| 15 2.3|
Acinar Cell, Hyperplasia | 3 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Pharynx | | 2 |
Palate, Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3| |
| 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.0666% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly | 2 | 1 2.0|
Infiltration Cellular, Lipocyte | | 1 1.0|
Acinar Cell, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 5 2.0|
Inflammation, Chronic | | 2 3.5|
Inflammation, Suppurative | 3 | 2 2.5|
Ulcer | 1 | 2 1.0|
Ulcer, Multiple | | 2 3.0|
Epithelium, Hyperplasia | 1 1 1 2 1 2 | 13 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Mineralization | | 1 2.0|
Necrosis, Focal, Multiple | 2 | 1 2.0|
Ulcer, Multiple | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 41 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 2 2.0|
Degeneration, Cystic | 4 | 1 4.0|
Hyperplasia, Focal | 2 2| 5 2.2|
Hyperplasia, Focal, Multiple | | 1 2.0|
Hypertrophy, Focal | 2 3 3 | 6 2.3|
Vacuolization Cytoplasmic, Focal | 3 | 8 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2| 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3| |
| 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.0666% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | 2 4 | 3 2.7|
Pars Distalis, Cyst, Multiple | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 | 6 2.2|
Pars Intermedia, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Ultimobranchial Cyst | 2 | 2 2.0|
C-Cell, Hyperplasia, Focal | 2 2 2 | 5 2.0|
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 2 2 3 2 2 | 18 2.4|
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 2 2.0|
Bilateral, Cyst | 3 2 3 3 3 2 2 | 11 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 | 5 3.0|
Bilateral, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 2 3.5|
Hyperplasia, Glandular | 2 | 2 2.5|
Infiltration Cellular, Lipocyte | | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 3 | 9 2.2|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythroid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | 2 | 5 2.6|
Mediastinal, Hemorrhage | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3| |
| 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.0666% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Multiple | 2 2 2 | 3 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 5 3.0|
Necrosis | 3 | 1 3.0|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 2 3 3 2 2 2 2 2 3 2 2| 22 2.2|
Duct, Cyst | 3 2 3 2 2 2 2 3 2 2 3 2 3 3 2 2 | 33 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nipple, Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 3.0|
Calvarium, Hyperostosis | 2 | 4 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 2 3 2 2 3 3 | 13 2.7|
Hemorrhage | | 2 2.0|
Hemorrhage, Multiple | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 2 2 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3| |
| 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.0666% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Fungus | 2 2 | 2 2.0|
Lumen, Inflammation, Suppurative | 2 2 | 2 2.0|
Submucosa, Pigmentation | 1 2 2 2 2 1 2 2 2 1 1 2 2 2 1 2 2 1 2 1 2 2 2| 46 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct, Multiple | | 1 3.0|
Nephropathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.2|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Mineralization | | 3 2.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 3 2 2 2 2 2 2 1 1| 45 1.9|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 8| 6| 6| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.0666% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 1 1 | 4 1.0|
Basophilic Focus, Multiple | 1 1 1 1 1 | 5 1.0|
Eosinophilic Focus | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 3 | 1 3.0|
Inflammation, Granulomatous, Multiple| 2 1 | 2 1.5|
Mixed Cell Focus | 2 1 | 2 1.5|
Bile Duct, Hyperplasia | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
Pars Distalis, Cyst, Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
Cyst | 2 2 2 | 3 2.0|
Cyst, Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 2 2 | 8 1.9|
Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
Capsule, Hypertrophy | 1 2 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 8| 6| 6| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.0666% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 6 |
Submucosa, Pigmentation | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Cyst | 3 | 1 3.0|
Nephropathy, Chronic | 1 1 2 2 1 | 5 1.4|
Renal Tubule, Dilatation | 1 1 1 1 1 2 | 6 1.2|
Renal Tubule, Mineralization | 2 2 1 2 1 2 1 | 7 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|
| 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0222% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Clear Cell Focus, Multiple | |
Eosinophilic Focus | 2 3 2 |
Eosinophilic Focus, Multiple | 3 |
Hepatodiaphragmatic Nodule | 2 3 |
Hyperplasia, Nodular | |
Inflammation, Granulomatous, Multiple| 1 2 1 2 1 2 2 2 2 1 2 1 2 1 1|
Mixed Cell Focus | 3 1|
Mixed Cell Focus, Multiple | |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 2 1 1 2 2 1 2 1 2 1 2 2 2 1 |
Serosa, Fibrosis | 3|
Serosa, Inflammation, Granulomatous | 3|
__________________________________________________________________________|
Mesentery | + + +|
Fat, Inflammation, Granulomatous | 3 |
Fat, Necrosis, Focal | 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | |
Acinar Cell, Atrophy | 2 2 3 2 2 |
Acinar Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | |
Ulcer, Multiple | 2 |
Epithelium, Hyperplasia | 3 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|
| 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0222% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis, Focal, Multiple | |
Ulcer | 2 |
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Atrium, Congestion | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 1 |
Hyperplasia, Focal | 2 2 3 2 2 2 |
Hypertrophy, Focal | 2 2 2 2 1 2 2|
Hypertrophy, Focal, Multiple | 3 2 |
Necrosis, Focal, Multiple | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 2 2 |
Vacuolization Cytoplasmic | 2 |
Vacuolization Cytoplasmic, Multiple | 2 2|
Bilateral, Vacuolization Cytoplasmic,| |
Focal | |
Bilateral, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 |
Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 2 3|
Pars Distalis, Cyst, Multiple | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 2 |
C-Cell, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | 3 2 3 3 2 2 2 2 3 2 |
Hyperplasia, Focal | 2 2 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|
| 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0222% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Cyst | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Granulomatous, Multiple| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Dilatation | |
Hyperplasia, Glandular | 2 2|
Inflammation, Suppurative | 3|
Cervix, Inflammation, Suppurative | 4 |
Endometrium, Hyperplasia, Cystic | 2 2 2 |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 3 |
Mediastinal, Pigmentation | 3 |
Pancreatic, Angiectasis | 2 |
Renal, Cyst, Multiple | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | |
Cyst | 2 |
Cyst, Multiple | 3 |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Edema | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 3 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Granulomatous | |
Pigmentation | 3 3 3 |
Capsule, Fibrosis | 3|
Capsule, Hypertrophy | |
Capsule, Inflammation, Granulomatous | 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|
| 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0222% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst, Multiple | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 3 3 2 2 2 4 2 2 2 2 2 2 2 2 |
Duct, Cyst | 3 3 3 2 2 4 2 2 2 3 4 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 2 |
Parakeratosis | 3 3 |
Ulcer | 3 2 |
Nipple, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
Calvarium, Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 4 2 |
Embolus Bacterial, Multiple | 3 |
Hemorrhage | 2 |
Inflammation, Multiple, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial, Multiple | 2 |
Hemorrhage, Multiple | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Infiltration Cellular, Multiple, | |
Histiocyte | |
Inflammation, Focal, Granulomatous | 3 3 |
Inflammation, Multiple, Suppurative | 3 |
Mineralization, Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
Lumen, Foreign Body | 2 |
Lumen, Fungus | 2 |
Lumen, Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|
| 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.0222% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lumen, Inflammation, Suppurative | 2 2 |
Nasolacrimal Duct, Hemorrhage | 2 |
Submucosa, Hemorrhage | 3 2 |
Submucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydronephrosis | 3 |
Infarct | 2 |
Inflammation, Suppurative | 3 |
Mineralization | |
Nephropathy, Chronic | 2 2 3 1 1 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 1 2 2|
Papilla, Necrosis | 4 |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Pigmentation | 2 1 2 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2 2 1 1 1 2 2|
Transitional Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Ureter | M |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Hemorrhage | 3 |
Inflammation, Suppurative | 4 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0.0222% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 | 5 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 3 2 2 2 2 2 2| 41 2.0|
Clear Cell Focus, Multiple | 1| 1 1.0|
Eosinophilic Focus | 3 X 3 2 2 | 8 2.4|
Eosinophilic Focus, Multiple | 2 | 2 2.5|
Hepatodiaphragmatic Nodule | 3 | 3 2.7|
Hyperplasia, Nodular | 3 | 1 3.0|
Inflammation, Granulomatous, Multiple| 2 2 2 1 2 1 2 3 1 1 1 2 2 1 1 | 30 1.6|
Mixed Cell Focus | 3 2 | 4 2.3|
Mixed Cell Focus, Multiple | 3 | 1 3.0|
Vacuolization Cytoplasmic | 3 3 | 3 2.7|
Bile Duct, Hyperplasia | 1 2 2 2 1 1 1 1 1 1 1 2 2 1 2 3 | 30 1.5|
Serosa, Fibrosis | | 1 3.0|
Serosa, Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Inflammation, Granulomatous | | 1 3.0|
Fat, Necrosis, Focal | 2 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | 2 | 1 2.0|
Acinar Cell, Atrophy | 2 2 2 3 2 2 | 11 2.2|
Acinar Cell, Hyperplasia | 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0.0222% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer, Multiple | | 1 2.0|
Epithelium, Hyperplasia | 3 1 4 2 | 8 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 3.0|
Mineralization | 2 | 1 2.0|
Necrosis, Focal, Multiple | 2 | 1 2.0|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2| 45 2.0|
Atrium, Congestion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 4 1.7|
Hyperplasia, Focal | 2 2 1 1 | 10 1.9|
Hypertrophy, Focal | 2 2 3 2 | 11 2.0|
Hypertrophy, Focal, Multiple | | 2 2.5|
Necrosis, Focal, Multiple | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 1 1 2 2 2 2| 15 1.8|
Vacuolization Cytoplasmic | 2 2 | 3 2.0|
Vacuolization Cytoplasmic, Multiple | | 2 2.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Focal | 2 | 1 2.0|
Bilateral, Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | | 1 2.0|
Hyperplasia, Focal | 2 | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 4 2.3|
Pars Distalis, Cyst, Multiple | 2 2 2 | 4 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 2 2 | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0.0222% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + M + +| 47 |
Cyst | 2 2 2 2 2 3 2 2 2 3 3 2 2 | 23 2.3|
Hyperplasia, Focal | 2 2 | 4 2.0|
Inflammation, Suppurative | | 1 3.0|
Bilateral, Cyst | 3 | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 3 2.3|
Inflammation, Granulomatous, Multiple| 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Dilatation | 3 3 3 | 3 3.0|
Hyperplasia, Glandular | | 2 2.0|
Inflammation, Suppurative | | 1 3.0|
Cervix, Inflammation, Suppurative | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Vagina | + + | 3 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 3 2.3|
Mediastinal, Pigmentation | | 1 3.0|
Pancreatic, Angiectasis | 3 | 2 2.5|
Renal, Cyst, Multiple | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 2 2.5|
Congestion | 2 | 1 2.0|
Cyst | | 1 2.0|
Cyst, Multiple | 2 | 2 2.5|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0.0222% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 | 3 2.7|
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Congestion | 2 | 2 2.5|
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Inflammation, Granulomatous | 3 2 | 2 2.5|
Pigmentation | 2 3 | 5 2.8|
Capsule, Fibrosis | | 1 3.0|
Capsule, Hypertrophy | 2 | 1 2.0|
Capsule, Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 3 2.0|
Cyst, Multiple | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 3 3 3 2 3 2 2 2 2 2 2 2 | 26 2.3|
Duct, Cyst | 2 2 3 2 3 2 2 2 2 2 2 2 3 2 2 2| 36 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 2 2.5|
Parakeratosis | | 2 3.0|
Ulcer | | 2 2.5|
Nipple, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 3.0|
Calvarium, Hyperostosis | 2 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 4 | 6 3.2|
Embolus Bacterial, Multiple | | 1 3.0|
Hemorrhage | 2 | 2 2.0|
Inflammation, Multiple, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0.0222% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Bacterial, Multiple | | 1 2.0|
Hemorrhage, Multiple | | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 2.0|
Infiltration Cellular, Multiple, | | |
Histiocyte | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | | 2 3.0|
Inflammation, Multiple, Suppurative | | 1 3.0|
Mineralization, Focal | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2| 3 2.3|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | 2 | 1 2.0|
Lumen, Foreign Body | | 1 2.0|
Lumen, Fungus | 3 | 2 2.5|
Lumen, Hyperkeratosis | | 1 4.0|
Lumen, Inflammation, Suppurative | 3 | 3 2.3|
Nasolacrimal Duct, Hemorrhage | | 1 2.0|
Submucosa, Hemorrhage | | 2 2.5|
Submucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 2 2| 48 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Cataract | 4 4 4 | 4 3.5|
Retina, Degeneration | 4 4 3 | 4 3.8|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hemorrhage | 3 | 2 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 2.5|
Hydronephrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0.0222% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infarct | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 2 1 | 2 1.5|
Nephropathy, Chronic | 2 2 2 2 2 4 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2 2| 46 2.0|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Pigmentation | 2 3 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1| 47 1.8|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Ureter | | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | | 1 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 7| 8| 8| 6| 6| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0222% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus, Multiple | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Clear Cell Focus | 1 | 1 1.0|
Inflammation, Granulomatous, Multiple| 1 1 1 1 2 | 5 1.2|
Bile Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Inflammation, Focal, | | |
Granulomatous | 3 | 1 3.0|
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 3 |
Pars Distalis, Cyst, Multiple | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
Cyst | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Dilatation | 2 | 1 2.0|
Cervix, Abscess | 3 | 1 3.0|
Cervix, Cyst | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 2 2 2 1 2 2 2 2 2 | 10 1.9|
Pigmentation | 2 3 2 2 1 3 2 3 3 2 | 10 2.3|
Capsule, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 7| 8| 8| 6| 6| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.0222% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + | 3 |
Submucosa, Pigmentation | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 1 2 1 1 1 1 1 2 | 9 1.3|
Renal Tubule, Mineralization | 1 1 1 1 1 2 | 6 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|
| 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Clear Cell Focus | 1 1 2 2 |
Clear Cell Focus, Multiple | 2 2 2 |
Degeneration, Cystic | 1 3 1 3|
Eosinophilic Focus | 1 2|
Eosinophilic Focus, Multiple | 4 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 2 2 |
Hyperplasia, Nodular | 3 3 1 3 2 |
Inflammation, Granulomatous, Multiple| 2 2 |
Mixed Cell Focus | 2 3 2 |
Mixed Cell Focus, Multiple | 2 |
Vacuolization Cytoplasmic | 3 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3|
Centrilobular, Degeneration | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Hemorrhage, Focal | |
Fat, Inflammation, Focal, | |
Granulomatous | 3 |
Fat, Necrosis, Focal | 3 2 3 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Ectopic Tissue | 2 |
Polyarteritis | 2|
Acinar Cell, Atrophy | 2 2 3 2 2 2 2 3 3 3 |
Acinar Cell, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|
| 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 3 |
Inflammation, Chronic | 3 |
Ulcer | 2 3 4 |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 3 2 2|
Atrium, Congestion | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 2 2 2 |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 2 2 2 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 |
Hyperplasia | 2|
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 2 2 2 |
Follicle, Cyst | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 |
Cyst | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|
| 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst, Multiple | |
Hyperplasia, Focal | |
Hyperplasia | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 3 3 |
Inflammation, Suppurative | 2 2 2 3 3 3 2 3 2 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 2 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 3 4 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Angiectasis | 3 2 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | 2 4 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst, Multiple | 2 3|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Edema | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 3 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|
| 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Lobular | 1 2 3 2 3 |
Duct, Cyst | 2 2 2 |
Duct, Hemorrhage | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoporosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 |
Hemorrhage | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis, Focal | 2 |
Inflammation, Granulomatous, Multiple| 2 |
Inflammation, Suppurative | 4 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 2 |
Lumen, Fungus | 2 3 3 3 3 2 3|
Lumen, Inflammation, Suppurative | 4 3 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 3 2 2 3 3 2 2 2 1 2 2 2 1 3 1 1 2 3 3 2 1 2 2 3 3|
Renal Tubule, Pigmentation | 1 2 1 1 2 2 2 2 1 1 2 2 2 2 1 1 1 1 1 3 1 1 1 1|
Transitional Epithelium, Hyperplasia | 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| |
| 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + A + + + + + + + + + + M + + + + + + + +| 46 |
Parasite Metazoan | 2 2 2 2 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 | 3 2.0|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2| 29 2.0|
Clear Cell Focus | 1 1 | 6 1.3|
Clear Cell Focus, Multiple | 1 1 2 1 | 7 1.6|
Degeneration, Cystic | 1 1 1 1 2 1 | 10 1.5|
Eosinophilic Focus | 3 2 2 3 | 6 2.2|
Eosinophilic Focus, Multiple | 2 | 2 3.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | 2 | 4 2.0|
Hyperplasia, Nodular | 2 2 | 7 2.3|
Inflammation, Granulomatous, Multiple| | 2 2.0|
Mixed Cell Focus | 2 | 4 2.3|
Mixed Cell Focus, Multiple | 1 | 2 1.5|
Vacuolization Cytoplasmic | 2 2 2 | 5 2.2|
Bile Duct, Hyperplasia | 3 2 2 2 2 1 2 2 3 2 2 2 2 2 1 2 2 2 3 2 2 2 2| 46 2.1|
Centrilobular, Degeneration | 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Fat, Hemorrhage, Focal | 3 3 | 2 3.0|
Fat, Inflammation, Focal, | | |
Granulomatous | | 1 3.0|
Fat, Necrosis, Focal | 3 3 3 3 | 7 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | 2 2 | 2 2.0|
Ectopic Tissue | | 1 2.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| |
| 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Atrophy | 2 2 2 2 2 2 3 2 | 18 2.3|
Acinar Cell, Hyperplasia | 2 2 2| 6 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly | 3 | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 3 3.0|
Inflammation, Chronic | 2 | 2 2.5|
Ulcer | | 3 3.0|
Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 3 2 2 2 2 3 2 2 3 2 3 3 3 2 2 3 2 2 2 2 3 3 2| 43 2.3|
Atrium, Congestion | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | 2 2 2 | 8 2.0|
Hyperplasia, Focal | 2 | 3 2.0|
Hypertrophy, Focal | 2 | 5 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 2 1 3 | 9 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 4 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 3 | 2 2.5|
Pars Distalis, Hemorrhage | 4 3 | 4 3.3|
Pars Distalis, Hyperplasia, Focal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia, Focal | 2 2 | 7 2.0|
Follicle, Cyst | 3 2| 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| |
| 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 6 2.2|
Cyst | 4 2 3 | 7 2.6|
Cyst, Multiple | 2 3 | 2 2.5|
Hyperplasia, Focal | 3 | 1 3.0|
Hyperplasia | 2 3 | 2 2.5|
Inflammation, Chronic | 3 | 2 3.0|
Inflammation, Suppurative | 2 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic | 3 3 | 4 3.0|
Inflammation, Suppurative | 2 3 3 2 2 2 2 3 3 2 3 2 2 | 24 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2 2 3 2 3 | 12 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 3 2 4 2 3 4 3 4 2| 16 3.1|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 | 3 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 | 16 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 2 2 | 3 2.3|
Mediastinal, Angiectasis | 2 3 2 | 9 2.2|
Mediastinal, Hyperplasia, Lymphoid | 3 | 2 3.0|
Mediastinal, Pigmentation | | 2 3.0|
Pancreatic, Angiectasis | 2 | 2 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Cyst, Multiple | 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| |
| 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 2 2 2 2 | 7 2.3|
Hematopoietic Cell Proliferation | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + M + + + + M + + +| 45 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lobular | 2 3 1 2 1 | 10 2.0|
Duct, Cyst | 2 2 2 2 | 7 2.0|
Duct, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Epidermis, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteoporosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 2 3 | 6 2.7|
Hemorrhage | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis, Focal | | 1 2.0|
Inflammation, Granulomatous, Multiple| 3 2 | 3 2.3|
Inflammation, Suppurative | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Foreign Body | | 1 2.0|
Lumen, Fungus | 3 2 2| 10 2.6|
Lumen, Inflammation, Suppurative | 2 2 2| 9 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| |
| 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 1 4.0|
Nephropathy, Chronic | 2 2 2 2 3 1 3 3 3 1 2 3 3 3 2 2 3 3 2 2 2 2 2 2| 49 2.2|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 2 1 2 1| 45 1.4|
Transitional Epithelium, Hyperplasia | 1 2 2 | 7 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
Parasite Metazoan | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 1 1 2 | 5 1.2|
Clear Cell Focus | 2 1 1 | 3 1.3|
Clear Cell Focus, Multiple | 1 1 | 2 1.0|
Degeneration, Cystic | 1 | 1 1.0|
Hepatodiaphragmatic Nodule, Multiple | 3 | 1 3.0|
Inflammation, Granulomatous, Multiple| 1 1 1 1 1 | 5 1.0|
Mixed Cell Focus | 3 2 | 2 2.5|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 | 8 1.0|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 2 | 10 1.2|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Inflammation, Focal, | | |
Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Inflammation, Chronic | 2 2 2 2 1 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Cyst | 3 3 4 | 3 3.3|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 2 3 2 2 | 6 2.2|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Fibrosis, Focal | 2 | 1 2.0|
Nephropathy, Chronic | 1 1 1 1 1 1 2 1 1 1 | 10 1.1|
Pelvis, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|
| 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
Mineralization | 3 |
Parasite Metazoan | 2 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Edema | |
Parasite Metazoan | 2 3 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Artery, Thrombosis | 4 |
Wall, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 1 |
Basophilic Focus, Multiple | 2 1 2 |
Clear Cell Focus | 2 1|
Clear Cell Focus, Multiple | 1 |
Degeneration, Cystic | 2 2 1 1 2 1 3 1 2 |
Eosinophilic Focus | 3 2 2 3 3 3 1 1 3 3 |
Eosinophilic Focus, Multiple | 3 3 2 3|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 2 3 3 |
Hyperplasia, Nodular | 3 2 3 2 2 2 |
Mixed Cell Focus | |
Necrosis | 4 3 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 2 2 2 3 3 1 2 2 3 2 2 2 2 2 2 3 3 2|
Centrilobular, Degeneration | |
Centrilobular, Necrosis | |
Vein, Thrombosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Polyarteritis | 2 4 |
Thrombosis, Multiple | 4 |
Fat, Hemorrhage, Focal | 4 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Ectopic Tissue | |
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|
| 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
Polyarteritis | 3 |
Acinar Cell, Atrophy | 2 2 3 2 2 2 3 2 3 |
Acinar Cell, Hyperplasia | 3 2 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 3 3 |
Inflammation, Chronic | 1 2 4 3 |
Mineralization | 3 |
Ulcer | 2 4 4 |
Ulcer, Multiple | 2 |
Epithelium, Hyperplasia | 3 2 2 2 2 3 4 2 2 3 2 3 3 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Inflammation, Chronic | |
Mineralization | 3 3 4 3 |
Polyarteritis | 3 |
Ulcer | |
Artery, Thrombosis | 4 |
Mucosa, Pigmentation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
Mesenteric Artery, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 3 3 2 2 3 2 3 3 2 2 3 3 2 3 2 2 2 2 2 2 3|
Mineralization | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Degeneration, Cystic | |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 1 |
Hypertrophy, Multiple | 3 |
Vacuolization Cytoplasmic, Focal | 3 1 3 |
Vacuolization Cytoplasmic, Focal, | |
Multiple | |
Vacuolization Cytoplasmic | 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|
| 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Spindle Cell, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Focal | 2 2 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
Artery, Polyarteritis | 2 |
C-Cell, Hyperplasia, Focal | 2 2 2 |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 2 2 2 |
Follicle, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | 3 3 3 3 3 |
Cyst | 4 4 2 3 4 3 2 |
Cyst, Multiple | 4 |
Hyperplasia | 2 |
Inflammation, Suppurative | 4 |
Bilateral, Atrophy | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
Inflammation, Chronic | 3 3 |
Inflammation, Suppurative | 2 3 3 2 2 3 2 2 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 3 4 |
Necrosis | |
Arteriole, Inflammation, Chronic | |
Bilateral, Atrophy | |
Bilateral, Interstitial Cell, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|
| 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Cyst | |
Inguinal, Hyperplasia, Lymphoid | 3 2 |
Mediastinal, Angiectasis | 2 2 |
Mediastinal, Pigmentation | 3 |
Pancreatic, Angiectasis | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 2 |
Renal, Angiectasis | 3 3 |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | |
Edema | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 |
Hematopoietic Cell Proliferation | |
Necrosis | 3 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2 2 3 3 2 3 2 1 2 3 3 1 1 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Hyperostosis | 3 |
Femur, Fibrous Osteodystrophy | 2 2 2 |
Maxilla, Fibrous Osteodystrophy | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|
DAY ON TEST | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|
| 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multiple | |
Inflammation, Granulomatous, Multiple| 2 |
Mineralization | 4 |
Alveolus, Pigmentation | |
Mediastinum, Polyarteritis, Multiple | 4 |
Mediastinum, Thrombosis, Multiple | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 3 |
Lumen, Foreign Body | 2 |
Lumen, Fungus | 3 3 3 2 3 2 3 2 |
Lumen, Inflammation, Suppurative | 3 2 2 2 2 3 2 |
Submucosa, Pigmentation | 1 1 2 2 2 2 2 2 2 1 1 1 2 2 2 1 2 2 2 2 1 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Cyst, Multiple | 3 4 3 4 2 |
Hydronephrosis | |
Nephropathy, Chronic | 3 4 4 4 3 3 2 4 4 3 2 2 4 4 4 1 2 3 4 4 2 4 3 3 1|
Renal Tubule, Hyperplasia | 2 1 |
Renal Tubule, Pigmentation | 1 2 2 1 1 1 2 2 1 2 2 1 1 1 1 2 1 1 2 1 1 1 2|
Transitional Epithelium, Hyperplasia | 1 2 2 2 2 2 1 1 2 2 2 2 1 1 2 1 |
__________________________________________________________________________|
Ureter | + |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7| |
DAY ON TEST | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2| |
| 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + A| 47 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Mineralization | | 1 3.0|
Parasite Metazoan | 3 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Dilatation | 4 | 1 4.0|
Edema | 2 | 1 2.0|
Parasite Metazoan | 2 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Artery, Thrombosis | | 1 4.0|
Wall, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | 1 1 1 | 4 1.0|
Basophilic Focus, Multiple | | 3 1.7|
Clear Cell Focus | | 2 1.5|
Clear Cell Focus, Multiple | 1 1| 3 1.0|
Degeneration, Cystic | 3 3 3 2 2 2 2 2 3 1 3 2 2 2 2| 24 2.0|
Eosinophilic Focus | 2 1 2 | 13 2.2|
Eosinophilic Focus, Multiple | 2 2 2 3 3 2 2 3 3 3 | 14 2.6|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 4 2.5|
Hyperplasia, Nodular | 2 3 3 2 3 3 3 2 | 14 2.5|
Mixed Cell Focus | 3 2 | 2 2.5|
Necrosis | | 2 3.5|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Bile Duct, Hyperplasia | 3 2 2 2 2 3 1 2 2 2 2 2 3 2 3 1 2 2 2 1 2 2| 40 2.1|
Centrilobular, Degeneration | 3 4 | 2 3.5|
Centrilobular, Necrosis | 2 | 1 2.0|
Vein, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Polyarteritis | | 2 3.0|
Thrombosis, Multiple | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7| |
DAY ON TEST | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2| |
| 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Hemorrhage, Focal | 3 | 2 3.5|
Fat, Necrosis, Focal | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Ectopic Tissue | X 2 | 2 2.0|
Fibrosis, Focal | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Polyarteritis | 2 | 2 2.5|
Acinar Cell, Atrophy | 2 2 2 2 | 13 2.2|
Acinar Cell, Hyperplasia | 3 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 3 2 3 3 3 3 | 11 2.9|
Inflammation, Chronic | 4 4 3 3 3 3 4 2 | 12 3.0|
Mineralization | | 1 3.0|
Ulcer | 3 3 2 3 4 2 2 3 3 3 2 4 | 15 2.9|
Ulcer, Multiple | | 1 2.0|
Epithelium, Hyperplasia | 2 2 2 3 4 4 2 2 3 3 3 4 3 3 3 3 2| 32 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Erosion | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 2 3| 6 3.0|
Polyarteritis | | 1 3.0|
Ulcer | 3 | 1 3.0|
Artery, Thrombosis | | 1 4.0|
Mucosa, Pigmentation, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
Mesenteric Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 3 2 3 2 2 2 2 3 2 2 2 2| 40 2.3|
Mineralization | | 1 2.0|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7| |
DAY ON TEST | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2| |
| 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Accessory Adrenal Cortical Nodule | 2 | 2 2.0|
Degeneration, Cystic | 4 | 1 4.0|
Hyperplasia, Focal | 3 | 2 2.5|
Hypertrophy, Focal | | 1 1.0|
Hypertrophy, Multiple | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 2 1 | 8 1.9|
Vacuolization Cytoplasmic, Focal, | | |
Multiple | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 1 2 2 | 11 1.5|
Spindle Cell, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hemorrhage | 3| 1 3.0|
Hyperplasia, Focal | 2 2 3 3 3 | 10 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Hyperplasia | 2 3 2 4 2 3 3 3 4| 14 2.9|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | | 2 2.5|
Pars Distalis, Hyperplasia, Focal | 2 3 2 3 | 5 2.4|
Pars Intermedia, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 3.0|
Artery, Polyarteritis | | 1 2.0|
C-Cell, Hyperplasia, Focal | | 3 2.0|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | 2 | 5 2.0|
Follicle, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | | 1 4.0|
Atrophy | 3 3 2 3 3 3 2 3 | 13 2.8|
Cyst | 4 2 3 3 3 2 2 3 3| 16 2.9|
Cyst, Multiple | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7| |
DAY ON TEST | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2| |
| 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 2 2.0|
Inflammation, Suppurative | 2 | 2 3.0|
Bilateral, Atrophy | 2 | 4 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 3.0|
Inflammation, Chronic | 3 | 3 3.0|
Inflammation, Suppurative | 2 3 3 3 3 2 2 | 17 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 4 3 4 2 3 3 2 4 3 3| 17 3.1|
Necrosis | 4 | 1 4.0|
Arteriole, Inflammation, Chronic | 3 | 1 3.0|
Bilateral, Atrophy | 3 | 1 3.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 2 | 5 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Myelofibrosis | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Cyst | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 3 | 3 2.7|
Mediastinal, Angiectasis | | 2 2.0|
Mediastinal, Pigmentation | 3 3 3 | 4 3.0|
Pancreatic, Angiectasis | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 3 2.7|
Renal, Angiectasis | 4 3 | 4 3.3|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 | 1 3.0|
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7| |
DAY ON TEST | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2| |
| 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis, Focal | 3 3 3 2 3 3 3 | 9 2.9|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis | | 1 3.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + M| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lobular | 1 2 2 1 2 1 2 1 2 1 | 23 1.9|
Duct, Cyst | 3 2 3 2 2 2| 7 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
Epidermis, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Hyperostosis | | 1 3.0|
Femur, Fibrous Osteodystrophy | 2| 4 2.0|
Maxilla, Fibrous Osteodystrophy | | 3 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 2 2.0|
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Multiple | 3| 1 3.0|
Inflammation, Granulomatous, Multiple| | 1 2.0|
Mineralization | | 1 4.0|
Alveolus, Pigmentation | 2 | 1 2.0|
Mediastinum, Polyarteritis, Multiple | | 1 4.0|
Mediastinum, Thrombosis, Multiple | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | 2 | 2 2.5|
Lumen, Foreign Body | 2 | 2 2.0|
Lumen, Fungus | 2 3 3 2 2 2| 14 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7| |
DAY ON TEST | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2| |
| 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.200% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lumen, Inflammation, Suppurative | 2 3 4 2 2 2 2| 14 2.4|
Submucosa, Pigmentation | 1 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2| 45 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Cyst | 2 3 2 | 6 2.2|
Cyst, Multiple | 3 2 | 7 3.0|
Hydronephrosis | 2 | 1 2.0|
Nephropathy, Chronic | 2 2 4 2 3 3 2 4 4 3 3 3 3 4 4 2 3 3 4 4 4 4 4 4| 49 3.2|
Renal Tubule, Hyperplasia | | 2 1.5|
Renal Tubule, Pigmentation | 3 2 1 2 2 1 2 2 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1| 46 1.4|
Transitional Epithelium, Hyperplasia | 2 2 1 1 1 2 3 2 2 2 1 2 2 1| 30 1.7|
__________________________________________________________________________|____________|
Ureter | | 1 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
Parasite Metazoan | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 | 1 1.0|
Clear Cell Focus | 1 | 1 1.0|
Hemorrhage, Focal | 4 | 1 4.0|
Hepatodiaphragmatic Nodule | 3 X | 2 3.0|
Inflammation, Granulomatous, Multiple| 1 1 2 1 1 3 1 | 7 1.4|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 | 8 1.0|
Bile Duct, Hyperplasia | 1 1 2 1 2 1 2 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Epithelium, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
Serosa, Fibrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Inflammation, Chronic | 2 1 2 1 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
Accessory Adrenal Cortical Nodule | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Hyperplasia, Focal | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Depletion Cellular | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Granuloma | 3 | 1 3.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 4 4 | 3 3.7|
Degeneration | 3 4 | 2 3.5|
Necrosis | 4 | 1 4.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 3 | 3 2.3|
Capsule, Hypertrophy | 1 1 2 1 2 2 1 1 | 8 1.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.200% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Inflammation, Focal, Granulomatous | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Lumen, Fungus | 4 | 1 4.0|
Lumen, Inflammation, Suppurative | 3 | 1 3.0|
Submucosa, Pigmentation | 1 1 1 1 2 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 2 2 3 3 1 2 3 3 2 | 10 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|
| 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0666% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Dilatation | 3 |
Parasite Metazoan | 3 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Parasite Metazoan | 2 2 2 X 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 2|
Clear Cell Focus | |
Clear Cell Focus, Multiple | 2 2 |
Degeneration, Cystic | 1 1 2 2 2 |
Eosinophilic Focus | 3 2 2 2 1 2 3 3 3 |
Eosinophilic Focus, Multiple | 2 |
Hepatodiaphragmatic Nodule | 3 2 |
Hyperplasia, Nodular | 3 2 3 2 3 2 |
Inflammation, Granulomatous, Multiple| 2 |
Mixed Cell Focus | 2 2|
Mixed Cell Focus, Multiple | |
Vacuolization Cytoplasmic | 2 2 3 |
Bile Duct, Hyperplasia | 3 3 2 2 2 3 2 3 2 2 2 2 2 1 3 2 2 2 3 2 3 2|
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Acinar Cell, Atrophy | 3 2 2 2 2 2 2 2 2 2|
Acinar Cell, Hyperplasia | |
Acinar Cell, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 2 2 |
Infiltration Cellular, Lipocyte | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|
| 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0666% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 4 3 |
Inflammation, Chronic | 3 |
Mineralization | 3 |
Ulcer | 2 2 2 3 2 |
Ulcer, Multiple | 3 3 |
Epithelium, Hyperplasia | 3 1 4 3 2 3 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Erosion, Multiple | |
Mineralization | 3 |
Ulcer | 2 |
Ulcer, Multiple | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 3 2 2 2 2 3 2 3 2 2 3 3 2 3 3 3 2 3|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 4 2 |
Degeneration, Cystic | |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|
| 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0666% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Atrophy | 3 2 3 3 3 2 2 3 |
Atrophy, Multiple | |
Autolysis | 3 |
Cyst | 3 2 3 3 2 2 3 2 2 2 3 2 2|
Cyst, Multiple | 3 3 3 |
Hyperplasia | 2 3 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 2 2 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 |
Hyperplasia, Glandular | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 2 4 3 4 2|
Bilateral, Atrophy | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 2 |
Interstitial Cell, Atrophy | 3 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Angiectasis | |
Mediastinal, Cyst, Multiple | X |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 2 |
Pancreatic, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|
| 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0666% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Cyst, Multiple | |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst, Multiple | |
Fibrosis | |
Hyperplasia, Lymphoid | 3 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Histiocytic, Lymphoid | |
Inflammation, Granulomatous, Multiple| |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + M M + M M + + + + + M M + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lobular | 2 3 2 2 2 1 1 2 1|
Duct, Cyst | 3 3 3 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Hemorrhage | 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 2 2|
Inflammation, Focal, Granulomatous | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|
| 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0666% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lumen, Foreign Body | 2 2 2 3|
Lumen, Fungus | 3 3 2 |
Lumen, Inflammation, Suppurative | 2 2 2 2 2 2|
Respiratory Epithelium, | |
Hyperkeratosis | |
Respiratory Epithelium, Hyperplasia | 3 |
Septum, Inflammation, Chronic | |
Submucosa, Inflammation, Suppurative | |
Submucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy, Chronic | 2 2 3 2 3 2 4 2 3 4 2 2 1 3 3 1 3 2 3 3 4 3 3 2 2|
Renal Tubule, Pigmentation | 2 2 2 2 2 1 1 2 1 1 1 2 1 2 1 1 1 2 1 2 2 2 2|
Transitional Epithelium, Hyperplasia | 2 2 2 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3| |
| 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0666% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | | 1 3.0|
Parasite Metazoan | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 3.0|
Parasite Metazoan | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 3.0|
Parasite Metazoan | 3 2 2 2 2 2 2 2| 13 2.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 3 | 4 2.8|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | 1 2 | 2 1.5|
Basophilic Focus, Multiple | 2 2 | 11 2.0|
Clear Cell Focus | 2 | 1 2.0|
Clear Cell Focus, Multiple | 1 1 | 4 1.5|
Degeneration, Cystic | 2 2 2 3 2 4 1 3 1 | 14 2.0|
Eosinophilic Focus | 3 2 3 3 2 2 | 15 2.4|
Eosinophilic Focus, Multiple | 3 3 2 3 3| 6 2.7|
Hepatodiaphragmatic Nodule | | 2 2.5|
Hyperplasia, Nodular | 3 2 2 3 3 3 2 3 4 3 3 3| 18 2.7|
Inflammation, Granulomatous, Multiple| 2 | 2 2.0|
Mixed Cell Focus | | 2 2.0|
Mixed Cell Focus, Multiple | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 4 2.3|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 3 2 3 3 2 2 2 3 3 3 3 2 3 3 2 3 2| 46 2.3|
Centrilobular, Degeneration | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Necrosis, Focal | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2| 1 2.0|
Acinar Cell, Atrophy | 2 2 2 2 2 2 2 2| 18 2.1|
Acinar Cell, Hyperplasia | 4 3 3 2 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3| |
| 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0666% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly | 3 3 | 4 2.5|
Infiltration Cellular, Lipocyte | 1 1 1 | 6 1.0|
Acinar Cell, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 | 5 3.2|
Inflammation, Chronic | | 1 3.0|
Mineralization | | 1 3.0|
Ulcer | 3 | 6 2.3|
Ulcer, Multiple | | 2 3.0|
Epithelium, Hyperplasia | 1 1 1 2 2 1 2 1 1 1 3 3 3 2 2 3| 25 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 2| 4 2.5|
Erosion, Multiple | 2 | 1 2.0|
Mineralization | | 1 3.0|
Ulcer | | 1 2.0|
Ulcer, Multiple | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 3 2 3 2 2 3 3 2 3 2 3 2 2 2 2 3 3 3 3| 42 2.5|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 2 | 5 2.4|
Degeneration, Cystic | 4 | 1 4.0|
Hyperplasia, Focal | 3 2 2 | 4 2.3|
Hypertrophy, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 2 2 2 2 | 11 2.0|
Vacuolization Cytoplasmic | 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2 2 3 2 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3| |
| 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0666% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + M + +| 47 |
Hyperplasia | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X 3 2 3 2 | 6 2.4|
Pars Distalis, Hyperplasia, Focal | 2 3 3 3 2 2 2| 11 2.4|
Pars Intermedia, Cyst | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 | 3 2.0|
C-Cell, Hyperplasia | 2 | 3 2.0|
Follicle, Cyst | 2 2 | 6 2.3|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 3.0|
Atrophy | 3 2 2 2 3 3 3 2 | 16 2.6|
Atrophy, Multiple | 2 | 1 2.0|
Autolysis | | 1 3.0|
Cyst | 3 2 4 2 3 2 2 2 3 3 3 | 24 2.5|
Cyst, Multiple | 3 2 3 3 | 7 2.9|
Hyperplasia | 2 3 | 5 2.4|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 3 | 2 3.5|
Inflammation, Suppurative | 2 3 3 4 3 3 2 3 3 2 2 | 17 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 2 2 | 7 2.4|
Hyperplasia, Glandular | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 2 2 4 3 4 3 | 15 3.1|
Bilateral, Atrophy | 4 3 | 2 3.5|
Bilateral, Interstitial Cell, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3| |
| 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0666% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 3 2.0|
Interstitial Cell, Atrophy | | 2 2.5|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 | 15 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Angiectasis | 3 3 | 2 3.0|
Mediastinal, Cyst, Multiple | | 1 |
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Pigmentation | | 1 2.0|
Pancreatic, Angiectasis | 3 3| 2 3.0|
Pancreatic, Cyst, Multiple | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst, Multiple | 3 2 2 | 3 2.3|
Fibrosis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 4 3 3 2 | 8 2.9|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Histiocytic, Lymphoid | 1 | 1 1.0|
Inflammation, Granulomatous, Multiple| 1 | 1 1.0|
Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | M + + M + + + + + + + + + + + + + + + + + + + + +| 42 |
Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + M + + + +| 47 |
Hyperplasia, Lobular | 1 1 1 2 | 13 1.6|
Duct, Cyst | 2 2 3 3 2 3 2 3 2 2 | 16 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3| |
| 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0666% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 | 4 3.0|
Hemorrhage | 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Histiocyte | 2 2 | 4 2.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Foreign Body | 2| 5 2.2|
Lumen, Fungus | 2 3 2 3 3 2| 9 2.6|
Lumen, Inflammation, Suppurative | 2 2 3 2 2 2 2| 13 2.1|
Respiratory Epithelium, | | |
Hyperkeratosis | 3 | 1 3.0|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
Septum, Inflammation, Chronic | 3 | 1 3.0|
Submucosa, Inflammation, Suppurative | 2 | 1 2.0|
Submucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3| |
| 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.0666% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 3 2 3 3 4 1 2 3 3 4 3 2 3 2 2 2 3 3 2 3 2 3 2 3 2| 50 2.6|
Renal Tubule, Pigmentation | 2 2 2 1 1 1 2 2 2 2 1 1 1 1 1 1 2 2 2 1 1 1 2 2 1| 48 1.5|
Transitional Epithelium, Hyperplasia | 2 2 2 | 9 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.0666% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Clear Cell Focus | 1 | 1 1.0|
Eosinophilic Focus | 1 1 1 | 3 1.0|
Hepatodiaphragmatic Nodule | 3 | 1 3.0|
Inflammation, Granulomatous, Multiple| 1 1 1 1 1 1 | 6 1.0|
Vacuolization Cytoplasmic | 1 1 1 1 2 1 1 1 | 8 1.1|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Accessory Spleen | 2 | 1 2.0|
Fat, Hemorrhage, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + + | 9 |
Atrophy | 3 2 | 2 2.5|
Cyst | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 | 1 2.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 2 2 2 | 5 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 8| 8| 6| 7| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.0666% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 | 1 2.0|
Capsule, Hypertrophy | 1 1 1 2 2 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 3 2 2 1 2 3 1 1 2 1 | 10 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|
| 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0222% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | 2 2 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + A + + + + + + + + +|
Ectopic Tissue | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Clear Cell Focus | 2 |
Clear Cell Focus, Multiple | 2 2 2|
Degeneration, Cystic | 2 1 1 1 2 |
Eosinophilic Focus | 2 2 2 3 |
Eosinophilic Focus, Multiple | 2 2 3 2 |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | 2 2 |
Hyperplasia, Nodular | 3 |
Inflammation, Granulomatous, Multiple| 2 |
Mixed Cell Focus, Multiple | 1 |
Necrosis | 4 |
Thrombosis, Multiple | 3 |
Vacuolization Cytoplasmic | 2 2 |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 1 2 2 2 2|
Centrilobular, Degeneration | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Inflammation, Focal, | |
Granulomatous | 2 3 |
Fat, Necrosis, Focal | 2 2 2 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Edema | 2 |
Polyarteritis | |
Acinar Cell, Atrophy | 2 3 2 3 2 2 2 2 2 2 |
Acinar Cell, Basophilic Focus | 2 2 |
Acinar Cell, Hyperplasia, Focal | 3 |
Acinar Cell, Hyperplasia | 3 3 2 3 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|
| 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0222% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytomegaly | 3|
Fibrosis, Focal | 2 |
Infiltration Cellular, Lipocyte | 1 1 1 2 2 1 1 1 2 1 2 1 1 2 1 1 1 2 1|
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic | |
Perforation | 4 |
Ulcer | 2 |
Epithelium, Hyperplasia | 3 1 1 1 1 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 3 2 2 2 2 3 2 3 2 2 3 3 2 2 3 2 3 2 2 2 3|
Atrium, Congestion | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 X 2 |
Hyperplasia, Focal | 2 2 2 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | 1 2 2 2 2|
Vacuolization Cytoplasmic, Focal, | |
Multiple | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 3 |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + + + + + + + + + + M + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Bilateral, C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|
| 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0222% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia, Focal | 2 2 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 2 2 2 3 3 |
Atrophy, Multiple | 2 2 |
Cyst | 2 3 2 3 3 3 2 2 2 |
Cyst, Multiple | 2 3 |
Hyperplasia, Focal | 3 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 3 |
Inflammation, Suppurative | 2 2 2 2 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 2 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 2 3 2 4 |
Bilateral, Atrophy | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 2 2 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 2|
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Angiectasis | 3 3 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 3 |
Cyst, Multiple | 2 2 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|
| 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0222% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 3|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 3 3 3 |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 2 |
Capsule, Hypertrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lobular | 2 1 1 2 2 1 1 2 1 1 1|
Duct, Cyst | 2 4 2 3 2 3 |
Duct, Hemorrhage | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Dermis, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Hemorrhage, Focal | |
Infiltration Cellular, Multiple, | |
Histiocyte | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Focal, Granulomatous | 2 2 |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | |
Lumen, Fungus | 4 3 3 4 |
Lumen, Inflammation, Suppurative | 4 3 2 2 3 |
Submucosa, Pigmentation | 1 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
_____________________________________________________________________________________________________________________
| 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|
| 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.0222% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Cyst, Multiple | 2 |
Nephropathy, Chronic | 1 1 2 4 3 1 1 3 3 2 2 3 2 2 3 3 2 2 2 3 3 2 2 2 2|
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 1 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1 2 1 1 1|
Transitional Epithelium, Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3| |
| 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.0222% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 | 2 1.5|
Basophilic Focus, Multiple | 2 2 2 2 2 2 2 2 1 2 2 2 2| 27 1.9|
Clear Cell Focus | 2 2 2 | 4 2.0|
Clear Cell Focus, Multiple | 2 2 2 | 6 2.0|
Degeneration, Cystic | 2 2 1 2 2 | 10 1.6|
Eosinophilic Focus | 3 2 2 2 1 2| 10 2.1|
Eosinophilic Focus, Multiple | 2 3 3 3 | 8 2.5|
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | 2 | 3 2.0|
Hyperplasia, Nodular | 2 | 2 2.5|
Inflammation, Granulomatous, Multiple| 2 | 2 2.0|
Mixed Cell Focus, Multiple | 1 | 2 1.0|
Necrosis | | 1 4.0|
Thrombosis, Multiple | | 1 3.0|
Vacuolization Cytoplasmic | 1 2 | 4 1.8|
Bile Duct, Hyperplasia | 2 2 2 3 3 2 2 3 2 2 2 2 2 2 2 2 2 2 1 2| 44 2.0|
Centrilobular, Degeneration | 3 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + + | 11 |
Fat, Inflammation, Focal, | | |
Granulomatous | 3 3 | 4 2.8|
Fat, Necrosis, Focal | 2 4 3 | 9 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 2.0|
Polyarteritis | 3| 1 3.0|
Acinar Cell, Atrophy | 4 2 2 2 2 2 3 2 1 2 2| 21 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3| |
| 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.0222% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinar Cell, Basophilic Focus | | 2 2.0|
Acinar Cell, Hyperplasia, Focal | | 1 3.0|
Acinar Cell, Hyperplasia | 2 3 2 3 3 | 10 2.7|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly | 3 2 2 2 2 2 2| 8 2.3|
Fibrosis, Focal | | 1 2.0|
Infiltration Cellular, Lipocyte | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1| 39 1.3|
Acinar Cell, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 | 3 3.0|
Inflammation, Chronic | 3 3 | 2 3.0|
Perforation | | 1 4.0|
Ulcer | 3 2 | 3 2.3|
Epithelium, Hyperplasia | 1 3 1 3 1 1 4 2 2| 16 1.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 3 2 2 2 2 3 3 2 3 3 2 2 2 2 2 2 2 3 3 2 2| 46 2.3|
Atrium, Congestion | | 1 3.0|
Atrium, Thrombosis | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 2 | 5 2.0|
Hyperplasia, Focal | 1 2 2 3 | 7 2.0|
Hypertrophy, Focal | 2 2 | 2 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 2 2 2 | 10 1.9|
Vacuolization Cytoplasmic, Focal, | | |
Multiple | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 1 2 2 2 3 | 9 2.2|
Bilateral, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3| |
| 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.0222% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Cyst, Multiple | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 | 9 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 1 2.0|
Bilateral, C-Cell, Hyperplasia | | 1 2.0|
C-Cell, Hyperplasia, Focal | 2 | 3 2.0|
Follicle, Cyst | 2 3 2 2 | 5 2.2|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 2 3 | 13 2.5|
Atrophy, Multiple | 3 | 3 2.3|
Cyst | 3 2 2 4 3 3 2 2 3| 18 2.6|
Cyst, Multiple | 3 3 | 4 2.8|
Hyperplasia, Focal | 3 | 3 2.7|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 3 | 6 2.5|
Inflammation, Suppurative | 3 2 2 2 3 2 1 2 2| 15 2.1|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 2 3 3| 12 2.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 2 3 2 2 3 | 13 2.5|
Bilateral, Atrophy | 3 | 1 3.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 | 5 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3| |
| 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.0222% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | 3 3 3 | 5 2.6|
Mediastinal, Hyperplasia, Lymphoid | 2 3| 2 2.5|
Pancreatic, Angiectasis | | 2 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3| 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 3.0|
Cyst, Multiple | 2 3 2 | 6 2.3|
Hyperplasia, Lymphoid | 2 2| 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2| 2 2.5|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 2 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 7 3.0|
Fibrosis, Focal | 3 3 3 3 | 5 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Capsule, Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lobular | 2 1 1 1 1 3 2 2 2 2 | 21 1.5|
Duct, Cyst | 3 2 3 3 2 2 3 2 2 3 2| 17 2.5|
Duct, Hemorrhage | 3 4 3 | 3 3.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Dermis, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3| |
| 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.0222% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythrophagocytosis | 2 | 1 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
Infiltration Cellular, Multiple, | | |
Histiocyte | 2 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Foreign Body | 2 2 2 | 3 2.0|
Lumen, Fungus | 2 3 2 3 2 | 9 2.9|
Lumen, Inflammation, Suppurative | 2 3 2 2 2 2 2 | 12 2.4|
Submucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 45 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4| 2 3.0|
Cyst, Multiple | | 1 2.0|
Nephropathy, Chronic | 2 3 2 3 3 2 2 3 2 3 3 3 2 3 2 1 3 3 3 3 1 3 4 3 3| 50 2.4|
Renal Tubule, Hyperplasia | 2 1 | 3 1.7|
Renal Tubule, Mineralization | 2 3 | 2 2.5|
Renal Tubule, Pigmentation | 1 1 1 2 1 1 2 2 1 2 2 1 1 1 2 1 2 1 1 2 1| 41 1.3|
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 | 9 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 7| 8| 8| 6| 6| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0222% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 | 1 1.0|
Clear Cell Focus, Multiple | 1 | 1 1.0|
Eosinophilic Focus | 1 | 1 1.0|
Eosinophilic Focus, Multiple | 1 | 1 1.0|
Inflammation, Granulomatous, Multiple| 1 1 1 1 | 4 1.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Bile Duct, Hyperplasia | 2 1 2 2 1 1 1 2 1 1 | 10 1.4|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Inflammation, Focal, | | |
Granulomatous | 2 | 1 2.0|
Fat, Necrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Cyst | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 2 | 3 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Capsule, Fibrosis, Focal | 3 | 1 3.0|
Capsule, Hypertrophy | 1 1 2 1 2 | 5 1.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05092-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROANISOLE Date: 04/28/97
Route: DOSED FEED Time: 07:07:25
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 7| 8| 8| 6| 6| 7| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.0222% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
15 SSAC | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy, Chronic | 2 1 1 1 1 1 1 1 2 1 | 10 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
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---------- END OF REPORT ----------
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