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TDMS Study 05092-01 Pathology Tables

NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 07:07:25




       Facility:  Southern Research Institute

       Chemical CAS #:  0091-23-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2                                2     2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          3  2                                                        2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             1            |             
      Basophilic Focus, Multiple           | 2  2  2  2  2              2  2  2  2  2  2  2  2     2  2        2     2|             
      Clear Cell Focus                     |                               2                    3                 2   |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Cytomegaly                           |                         3                                                |             
      Eosinophilic Focus                   |                                                       2                  |             
      Eosinophilic Focus, Multiple         |             3              3     3                       2               |             
      Hepatodiaphragmatic Nodule           |                                     2                                   X|             
      Hyperplasia, Nodular                 |                         3                       2                        |             
      Inflammation, Granulomatous, Multiple| 2     2  2  2              1  2  1  1  1  1  2     2  3  1     1  2  1  2|             
      Karyomegaly                          |                         3                                                |             
      Mixed Cell Focus                     |                                                                         2|             
      Vacuolization Cytoplasmic            |                2  4  4                       4        2                  |             
      Bile Duct, Hyperplasia               |    1  1  1  1  2     2  2           2  2     2  2                 2     1|             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +           +              +                           |             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                   3           3                                          |             
      Fat, Necrosis, Focal                 |                   3           3              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                    3                     |             
      Acinar Cell, Atrophy                 |       2        2  2  4  3              2  2           2                  |             
      Acinar Cell, Hyperplasia             |                                  2                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              3                           |             
      Inflammation, Suppurative            |                                              2                           |             
      Acinar Cell, Atrophy                 |                                              3                           |             
      Acinar Cell, Hyperplasia             |                                                    4                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                              3     3                     |             
      Ulcer                                |                                                    4                     |             
      Ulcer, Multiple                      |                                                                          |             
      Epithelium, Hyperplasia              |    2                                         3     4                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion, Multiple                    |                                                                          |             
      Epithelium, Hyperplasia              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  2     2  2           2  2  2  2  3  2  2     2  2        2  3  3  2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             2           2                                   2        2   |             
      Hyperplasia, Focal                   |          2  2           2                 1                              |             
      Hypertrophy, Focal                   |                      2                 2                       2     2   |             
      Vacuolization Cytoplasmic, Focal     |    2                          2  1     2           2  2              2   |             
      Vacuolization Cytoplasmic            |                2                                                         |             
      Bilateral, Hypertrophy, Focal        | 2                                                                        |             
      Bilateral, Vacuolization Cytoplasmic |                   3                                                      |             
      Spindle Cell, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          2                 2                                             |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    2                                                                     |             
      Pars Distalis, Cyst, Multiple        |             3                                                            |             
      Pars Distalis, Hyperplasia, Focal    |                                     3  2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                2                                                         |             
      C-Cell, Hyperplasia, Focal           | 2  2                                                  2                  |             
      C-Cell, Hyperplasia                  |                      2  2                                                |             
      Follicle, Cyst                       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                 4                        |             
      Atrophy                              |                                                                          |             
      Cyst                                 |          X              3        2        3  3  3     2                 3|             
      Cyst, Multiple                       |                                                             3            |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                   3                       2     3  3           2        2|             
      Inflammation, Suppurative            |                                                                         2|             
      Bilateral, Cyst                      |                   3                                3           2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            2  3                                          |             
      Bilateral, Cyst                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Glandular               |                2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Cervix, Cyst                         |                      2                                                   |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |          2                          2                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Angiectasis             |          2  3                                            2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst, Multiple                       | 2           2                                                            |             
      Hyperplasia, Lymphoid                |       3                                               2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                2                                3                        |             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Pigmentation                         |                                              3     3  3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |    2  2                 3  3  2  2     2  2     2        2           2   |             
      Duct, Cyst                           | 2  3  2     2  2  2  2        2  2  2        4     3  3     X  4        3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 6| 7| 8| 2| 2| 2| 2| 2| 3| 9| 0| 0| 3| 3| 8| 1| 3| 3| 3|             
                                           | 8| 8| 8| 8| 8| 4| 9| 3| 7| 9| 9| 9| 9| 9| 0| 4| 0| 0| 0| 0| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                  4              3                        |             
      Calvarium, Hyperostosis              |                         2                       3              2         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            3                 3     3  3        3        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                      3   |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Multiple,     |                                                                          |             
           Histiocyte                      |                                                                      2   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Focal, Granulomatous   |                   2                                2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                                           3  3                           |             
      Lumen, Inflammation, Suppurative     |                                           3  2                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Submucosa, Pigmentation              | 1  1  2  2     1  1  2  2  2     1  2  1  1  2  2  2  2  2  1     1  1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Hemorrhage                           |                3                                                         |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Chronic                |                               2                                          |             
      Nephropathy, Chronic                 | 2  2     2  2  2     2  2  2     2     2  2  3  2  2  2  2     3  3     2|             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1     1  1  1  1     1  1  1  1           1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                 2                        |      2  1.5|
      Basophilic Focus, Multiple           | 2  2  2     2  2  2  2  1  2  1     2  2  2        2  2  2  2  2  2     2|     37  1.9|
      Clear Cell Focus                     |          3        3                                                      |      5  2.6|
      Clear Cell Focus, Multiple           |       2                                                                  |      1  2.0|
      Cytomegaly                           |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                         2                                      2         |      3  2.0|
      Eosinophilic Focus, Multiple         |                                                                      3   |      5  2.8|
      Hepatodiaphragmatic Nodule           |                            3     X                                       |      4  2.5|
      Hyperplasia, Nodular                 |                                  3              3                        |      4  2.8|
      Inflammation, Granulomatous, Multiple| 2  2  2  1        2  2  1  2  2     2  1           2  2  2  2  2  2     1|     36  1.7|
      Karyomegaly                          |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                        2                                 |      2  2.0|
      Vacuolization Cytoplasmic            |                   3              4  3        3  2                        |     10  3.1|
      Bile Duct, Hyperplasia               | 2  1     1  1     1  1  1        2  1     2  2  3  1     2     1  2      |     29  1.6|
      Centrilobular, Degeneration          |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +        +     +                 +                           |   9        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                                                                          |      2  3.0|
      Fat, Necrosis, Focal                 |             3        2     2                 3                           |      7  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 2                                      2                                 |      3  2.3|
      Acinar Cell, Atrophy                 |    2     2                             2              2              2  2|     14  2.2|
      Acinar Cell, Hyperplasia             | 2        3                 2                                      3  2   |      6  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Atrophy                 |                                                                          |      1  3.0|
      Acinar Cell, Hyperplasia             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                   4              2  3                                    |      4  3.0|
      Inflammation, Chronic                |                                     2           3                        |      4  2.8|
      Ulcer                                |                                                                          |      1  4.0|
      Ulcer, Multiple                      |                   4                 3                                    |      2  3.5|
      Epithelium, Hyperplasia              |                   3              2  3           2        2               |      8  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                              3                           |      1  3.0|
      Erosion, Multiple                    |                                  2                                       |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2  2  2  2        2  2  3  1     2  2  2     2  2     2        2  2   |     34  2.1|
      Atrium, Thrombosis                   |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                               2                    X                     |      6  2.0|
      Hyperplasia, Focal                   |                                                                          |      4  1.8|
      Hypertrophy, Focal                   |                         2                       2                    2   |      7  2.0|
      Vacuolization Cytoplasmic, Focal     |    2        2     2              2     1              2                 1|     14  1.8|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Bilateral, Hypertrophy, Focal        |                                                                          |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic |                                                                          |      1  3.0|
      Spindle Cell, Hyperplasia, Focal     |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                   2                                                      |      3  2.0|
      Vacuolization Cytoplasmic, Focal     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                         2                    3                       2   |      4  2.3|
      Pars Distalis, Cyst, Multiple        |                                  2        2                       2      |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                         3        3        3                              |      5  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |       2           2              2  3        2  2                        |      9  2.1|
      C-Cell, Hyperplasia                  |          2                                2           2                  |      5  2.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Abscess                              |                                                                          |      1  4.0|
      Atrophy                              |                                                 3                        |      1  3.0|
      Cyst                                 |       2        3           3     2     2              3                  |     14  2.6|
      Cyst, Multiple                       |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                             2            |      1  2.0|
      Hyperplasia                          |                                        2              3                  |      8  2.5|
      Inflammation, Suppurative            |                                                       3                  |      2  2.5|
      Bilateral, Cyst                      | 2                                               3           2        3   |      7  2.6|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   2                             3           2            |      5  2.4|
      Bilateral, Cyst                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                         2                                            3   |      2  2.5|
      Hyperplasia, Glandular               |    2                                                                     |      2  2.0|
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
      Cervix, Cyst                         |                                           4                              |      2  3.0|
      Cervix, Inflammation, Suppurative    |                                           3                              |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    2     3                       2     2           2                     |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |                                              4                           |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                         3|      1  3.0|
      Mediastinal, Angiectasis             |    3                                                  2  2               |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst, Multiple                       |                                                          2               |      3  2.0|
      Hyperplasia, Lymphoid                | 2                       2                                2     3     3   |      7  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                3         |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                3                                                         |      2  2.5|
      Pigmentation                         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |    3  2  2  3     2              2                             2  2      |     19  2.2|
      Duct, Cyst                           | 2  3     2  2  2  3     3  3     3  3  2  3  2  2  2  3  2  3  3  2  3  3|     38  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      2  3.5|
      Calvarium, Hyperostosis              |    2        2                                                           2|      6  2.2|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    3              3                 4              3                     |     10  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis                          |                                                                          |      1  3.0|
      Edema                                |                                              3                           |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |          2                                                               |      1  2.0|
      Infiltration Cellular, Multiple,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                          2           2   |      2  2.0|
      Inflammation, Focal, Granulomatous   |                                        2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Fungus                        |                                                             2           3|      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 3| 3| 3| 1| 2| 3| 3| 3| 3| 6| 2| 3| 3| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 8| 3| 1| 1| 1| 8| 3| 9| 1| 1| 4| 7| 0| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lumen, Inflammation, Suppurative     |                                                             2           2|      4  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   3                                                      |      1  3.0|
      Submucosa, Pigmentation              | 1  1  2  1  1  1  2  1  2  2  1  2  1  2  2     2  2  1  2  2  2  2  2  2|     46  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                      3   |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 2  3     2  2  2  3     2  2        2  2  2     2  2  2  2  2  2  2  2  2|     39  2.1|
      Renal Tubule, Mineralization         |                                        2                                 |      1  2.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1  1  1     1  1     2  1  1  1  1     1  1   |     41  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    |          2  1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |    1                       1                                             |      2  1.0|
      Basophilic Focus, Multiple           | 1     2  2  1  1     1  2                                                |      7  1.4|
      Inflammation, Granulomatous, Multiple|    1  1  2  1              1                                             |      5  1.2|
      Mixed Cell Focus                     |    2                                                                     |      1  2.0|
      Bile Duct, Hyperplasia               |    1  1     1                                                            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
      Fat, Necrosis, Focal                 |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Spindle Cell, Hyperplasia, Focal     |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Hyperplasia, Focal    |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |    3              3        2                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 | 2                                                                        |      1  2.0|
      Bilateral, Cyst                      |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           | 2  3                                                                     |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |       1                 2                                                |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Reticulum Cell          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |      1  2.0|
      Pancreatic, Pigmentation             | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Duct, Cyst                           |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Calvarium, Hyperostosis              |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Submucosa, Pigmentation              | 1  1  1  1     1  1  1     1                                             |      8  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic, Focal         |                   3                                                      |      1  3.0|
      Nephropathy, Chronic                 |    1           1  2                                                      |      3  1.3|
      Renal Tubule, Dilatation             |                   3                                                      |      1  3.0|
      Renal Tubule, Mineralization         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     2     2              2               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Wall, Foreign Body                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Basophilic Focus                     |          2                                                               |             
      Basophilic Focus, Multiple           | 2  2  2     1        2              2  2  2  2  2  2     2           1  2|             
      Clear Cell Focus                     |                                        2                                 |             
      Clear Cell Focus, Multiple           |    1                                         2                           |             
      Eosinophilic Focus                   |                                     2     2              2        2     2|             
      Eosinophilic Focus, Multiple         | 2     2                 2                                                |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Hepatodiaphragmatic Nodule           |                                              3                    3      |             
      Hyperplasia, Nodular                 |          3           2        3  2                          3  3         |             
      Inflammation, Granulomatous, Multiple| 2  2  1     2           2  2        1  2     2     1     1              2|             
      Mixed Cell Focus                     |                3                                   1  1                  |             
      Vacuolization Cytoplasmic            |                   2        2                                   3         |             
      Bile Duct, Hyperplasia               |       1  2  2     2  2  2  1  2  2  1  2  2     2  1  2  2  2  2  1  1  1|             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                2                                                         |             
      Vein, Thrombosis                     |                                                             3            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +              +     +                                   +   |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                                  3                                       |             
      Fat, Necrosis, Focal                 |       2     3              3     3                                   3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | 2        2                                                               |             
      Ectopic Tissue                       |                                                                          |             
      Acinar Cell, Atrophy                 |       2              2              3  2           2        2     2      |             
      Acinar Cell, Hyperplasia             |                      3  3                       2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |                                                                          |             
      Acinar Cell, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               3  2                                       |             
      Inflammation, Chronic                |                                  3                                      3|             
      Ulcer                                |                                                             2  2         |             
      Ulcer, Multiple                      |                                  3                                       |             
      Epithelium, Hyperplasia              | 2     2  2  3     1           2  3     2  2  3           1  2  2  2     3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  2                             2         |             
      Ulcer                                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  2     2     2  2  2  2        2  2  2  2  2  2  3  3  2  2  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      2                                2  2               |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                   4                                         2            |             
      Hyperplasia, Focal                   |                                        2     2           2        2      |             
      Hypertrophy, Focal                   |       2                                                                  |             
      Vacuolization Cytoplasmic, Focal     |    2        2                       2  2  2                    2        2|             
      Bilateral, Hyperplasia               |                            2                                             |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Focal                           |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic |                                  3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                          2     3     2   |             
      Pars Distalis, Cyst, Multiple        |                            2     2  2                       2            |             
      Pars Distalis, Hyperplasia, Focal    |                2        2  3  3                    2  2  2               |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                         2                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |       2           2                                                     2|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |          2                 2  3  3  2  2  3                              |             
      Hyperplasia                          |                                           3                             2|             
      Inflammation, Suppurative            |                                                                          |             
      Bilateral, Cyst                      |                                                             3     2  3  3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3        3           2  4                    2                     |             
      Cyst, Multiple                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                 3        3               |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |    4                                                                     |             
      Hyperplasia, Glandular               |    3                 3                                                   |             
      Cervix, Hemorrhage                   |                                                                          |             
      Cervix, Myometrium, Hyperplasia      |                      3                                                   |             
      Endometrium, Hyperplasia, Cystic     | 2           2                                   2     3        3        3|             
      Vein, Thrombosis                     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |          3                             2                                3|             
      Mediastinal, Congestion              |                3                                                         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                                         3|             
      Pancreatic, Angiectasis              |                      3                                      3     3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                      3                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                       4                  |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                              3                           |             
      Hyperplasia, Lymphoid                |                         3                                                |             
      Mediastinum, Edema                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 | 3     2  2        3  2              3  3  2  2  2  2  2  2        2     2|             
      Duct, Cyst                           | 2  2     2  3     2     2     3  2        2     2     2     2  4  2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                      3   |             
      Calvarium, Hyperostosis              | 2                          2                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 2        3                             2                                 |             
      Hemorrhage, Multiple                 |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Multiple,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Inflammation, Focal, Granulomatous   |                            3                          2                  |             
      Inflammation, Granulomatous, Multiple|                         2                                                |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
      Alveolus, Pigmentation               |                                     2              2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Submucosa, Pigmentation              | 2  2  1  2  2  2  1  2  2  2  1  1  1  2  2  1  2  2  2  1  1  2  3  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 7| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 6| 4| 9| 0| 0| 1| 0| 0| 0| 0| 2| 2| 2| 2| 2| 7| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                 +              +                                 |             
      Cataract                             |       2                 2              4                                 |             
      Inflammation, Suppurative            |                                                                          |             
      Retina, Degeneration                 |       4                 4              4                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Hemorrhage                           |             3                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  3  3  3  2  2  3  2     2  2  2  2  3  2  3     3  3  2  2  3  2  3|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Mineralization         |                                                    1                     |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           | 1  1  1  2  1     3  1  1  1  1  1  1  1  1  2  1  2  1  1  1  1  1  3  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Chronic                |       1                                                                  |             
      Transitional Epithelium, Hyperplasia |       2                          2                 4     1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    0.200%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                2                                2     2                  |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Wall, Foreign Body                   |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Granulomatous          |       4                                                                  |      1  4.0|
      Ulcer                                |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                   1                                                     1|      3  1.3|
      Basophilic Focus, Multiple           |    2  2  2  2  1        2              2           2  2  2        1  3   |     26  1.9|
      Clear Cell Focus                     |             1                                                        2   |      3  1.7|
      Clear Cell Focus, Multiple           |                                                                          |      2  1.5|
      Eosinophilic Focus                   |                                  2              3     2                 1|      9  2.0|
      Eosinophilic Focus, Multiple         |                   2     3                                                |      5  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           | 2  2                                      3           2              3  2|      8  2.5|
      Hyperplasia, Nodular                 | 3                    3              3     3     3        3  2  3         |     14  2.8|
      Inflammation, Granulomatous, Multiple|    2           1        1  1  2                    2  1              1  1|     21  1.5|
      Mixed Cell Focus                     |    2                                            2                        |      5  1.8|
      Vacuolization Cytoplasmic            | 4                                                              4         |      5  3.0|
      Bile Duct, Hyperplasia               | 2  2  1  2  2  1  2  2  2  1     2  3  2  2  1  2  2     2  2  1  1  1   |     43  1.7|
      Centrilobular, Necrosis              |                                              3                           |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +  +                             +  +           +           +|  12        |
      Inflammation, Chronic                |                                              4                           |      1  4.0|
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |          3  2                                   3           3           3|     10  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    0.200%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |                                                                          |      2  2.0|
      Ectopic Tissue                       |       3                                                                  |      1  3.0|
      Acinar Cell, Atrophy                 | 2     3        4           2                                         2   |     12  2.3|
      Acinar Cell, Hyperplasia             |          3              3                                                |      5  2.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinar Cell, Atrophy                 |          2                                                               |      1  2.0|
      Acinar Cell, Hyperplasia             | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                | 3                    4                                                  2|      5  2.8|
      Inflammation, Chronic                |                         4     4           2                             3|      6  3.2|
      Ulcer                                |                      3  3     4                                         3|      6  2.8|
      Ulcer, Multiple                      |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              | 3     3     1        4  4     4        3  3  1        2     1  3        3|     28  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      2  2.0|
      Ulcer                                | 2                                                                        |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  2  3  2  3  2  2     3     2  2     3  2        3  2  3        2  2  2|     39  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |             2                 2              2     2                     |      7  2.0|
      Cyst                                 |                                                                      3   |      1  3.0|
      Degeneration, Cystic                 |                                                                          |      2  3.0|
      Hyperplasia, Focal                   |                                           3                          2   |      6  2.2|
      Hypertrophy, Focal                   |          1              2              2                 2               |      5  1.8|
      Vacuolization Cytoplasmic, Focal     |                                           2                 2  2        1|     11  1.9|
      Bilateral, Hyperplasia               |                                                                          |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Focal                           |       2                                                                  |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic | 3                                   2                                    |      3  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    0.200%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                           2                              |      1  2.0|
      Pars Distalis, Cyst                  |                2                    2                                    |      5  2.2|
      Pars Distalis, Cyst, Multiple        |                                           2        2                     |      6  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      7  2.3|
      Pars Distalis, Hyperplasia           |                                        2  3                 3        3   |      4  2.8|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |          2                          2                                    |      5  2.0|
      C-Cell, Hyperplasia                  |                3        2                                                |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Cyst                                 | 3           3  3     3              3     3        3     2               |     15  2.7|
      Hyperplasia                          |                   2                       3           3           2      |      6  2.5|
      Inflammation, Suppurative            |                               3                       3                  |      2  3.0|
      Bilateral, Cyst                      |                   3     3     2              3        3        3  2      |     11  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      5  2.8|
      Cyst, Multiple                       |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                           2                             3|      4  2.8|
      Fibrosis, Focal                      |                                     2                                    |      1  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Glandular               |             2                    2                       3               |      5  2.6|
      Cervix, Hemorrhage                   |                                              4                           |      1  4.0|
      Cervix, Myometrium, Hyperplasia      |          3                                                     3         |      3  3.0|
      Endometrium, Hyperplasia, Cystic     |             2           3                             2  2  2  2         |     12  2.3|
      Vein, Thrombosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +                                +                          +            |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Angiectasis             |                               2  3     3                                 |      6  2.7|
      Mediastinal, Congestion              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    0.200%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hemorrhage              |                                              2                           |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |             3                                                        3   |      2  3.0|
      Mediastinal, Pigmentation            | 3                                                                        |      2  3.0|
      Pancreatic, Angiectasis              |             2                 3                                3         |      6  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         |             2                 2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Hyperplasia, Lymphoid                |                                                    3                     |      1  3.0|
      Inflammation, Chronic                |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                           2                              |      1  2.0|
      Hematopoietic Cell Proliferation     |                3                             4                           |      3  3.7|
      Inflammation, Granulomatous          |       3                                                                  |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                            2                                             |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Mediastinum, Edema                   |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |       3  3                          3              2  2  3               |     21  2.4|
      Duct, Cyst                           | 2  2  3     2     3  2  4     3  2     3  3     3  2  2  2  3  3  3     3|     34  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                               3                                          |      1  3.0|
      Epidermis, Hyperplasia               |                               3                                          |      1  3.0|
      Subcutaneous Tissue, Edema           |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      1  3.0|
      Calvarium, Hyperostosis              |       2                                            3                    2|      5  2.2|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    0.200%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                         3     4                                         3|      6  2.8|
      Hemorrhage, Multiple                 |                                                                2         |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |             2                                                            |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                         2                          2                     |      2  2.0|
      Infiltration Cellular, Multiple,     |                                                                          |            |
           Histiocyte                      |                                                       3              3   |      2  3.0|
      Inflammation, Focal, Granulomatous   |                                        2              3                  |      4  2.5|
      Inflammation, Granulomatous, Multiple|                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 4                                                                        |      2  3.0|
      Alveolus, Pigmentation               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Fungus                        | 2                                                                        |      1  2.0|
      Lumen, Inflammation, Suppurative     | 2                                                                        |      1  2.0|
      Submucosa, Pigmentation              | 2  2  1  2  2  2  2  2  2  1  2  2  2  2  2  1  1  2  2  2  2  2  2  2  2|     50  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +        +                                                         |   5        |
      Cataract                             |       3                                                                  |      4  2.8|
      Inflammation, Suppurative            |                3                                                         |      1  3.0|
      Retina, Degeneration                 |       3                                                                  |      4  3.8|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                    +                     |   1        |
      Inflammation, Suppurative            |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2     3  2  2     2  2  3     4  2  2  3  3  2  2  3  2  2  2  2  2     3|     44  2.4|
      Renal Tubule, Dilatation             |                            3                                             |      1  3.0|
      Renal Tubule, Mineralization         |                            2                                             |      2  1.5|
      Renal Tubule, Necrosis               |                                                 3                        |      1  3.0|
      Renal Tubule, Pigmentation           | 2  2  2  2  2     2  1  2     2  2  1  2  2     2  2  2  2  2  3  2  2  2|     46  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 6| 7| 3| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 0| 1| 6| 1| 8| 0| 4| 2| 3| 3| 5| 8| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 9| 2| 2| 2| 2| 0| 3| 3| 6| 6| 4| 7| 9| 5| 5| 5| 7| 5| 5| 5| 1| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    0.200%                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                                                   2      |      1  2.0|
      Inflammation, Chronic                |                                                          1               |      2  1.0|
      Transitional Epithelium, Hyperplasia |                                                          1        1      |      6  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5|                                            |            |
                                           | 6| 7| 7| 8| 8| 7| 6| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |    1     1                                                               |      2  1.0|
      Basophilic Focus, Multiple           |                         1                                                |      1  1.0|
      Hepatodiaphragmatic Nodule           |                         3                                                |      1  3.0|
      Inflammation, Granulomatous, Multiple| 1     1     1        1     1                                             |      5  1.0|
      Mixed Cell Focus                     |    1                                                                     |      1  1.0|
      Necrosis                             |                   1                                                      |      1  1.0|
      Bile Duct, Hyperplasia               |             1        1  1  1                                             |      4  1.0|
      Hepatocyte, Kupffer Cell,            |                                                                          |            |
          Pigmentation                     | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +  +  +                                                            |   4        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |       2  3  3                                                            |      3  2.7|
      Fat, Necrosis, Focal                 |    3        3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperplasia              |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic                |       1     2                                                            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5|                                            |            |
                                           | 6| 7| 7| 8| 8| 7| 6| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Cyst, Multiple        |                   2                                                      |      1  2.0|
      Pars Distalis, Hyperplasia           |                3                                                         |      1  3.0|
      Pars Intermedia, Cyst                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                   4                                                      |      1  4.0|
      Hyperplasia                          |                      3     3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pigmentation                         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5|                                            |            |
                                           | 6| 7| 7| 8| 8| 7| 6| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.200%                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Submucosa, Pigmentation              | 2  1  1  1  1  1  1  1  2  2                                             |     10  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 |          2  2     1        2                                             |      4  1.8|
      Renal Tubule, Dilatation             | 2        2  2  2  1  2  1  2                                             |      8  1.8|
      Renal Tubule, Mineralization         | 2     1     1  2     2     2                                             |      6  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|             
                                           | 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0666%                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          1                       1                          1            |             
      Basophilic Focus, Multiple           |    2  2     2     2  2  2  2        2  2  2        3  2  2     2  2  2  1|             
      Clear Cell Focus                     |                            1                                   2         |             
      Degeneration, Multiple               |                                                                          |             
      Eosinophilic Focus                   | 2                                   2                 2                  |             
      Eosinophilic Focus, Multiple         |          3                                                           2   |             
      Hepatodiaphragmatic Nodule           |          2                 2     2                                   2   |             
      Hyperplasia, Nodular                 |                                        2                                 |             
      Inflammation, Granulomatous, Multiple| 1     2  1  2        1  1  2                                3  2         |             
      Mixed Cell Focus                     |                         2                          2                     |             
      Necrosis                             |                                              4                           |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |    2                                   2                                 |             
      Bile Duct, Hyperplasia               | 1     2        1        2  2        2  2  2     1  2     2     1  2  1  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +                 +  +     +                  |             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Fat, Necrosis, Focal                 |    2                       2                          2                  |             
      Fat, Necrosis, Focal, Multiple       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                                                                          |             
      Acinar Cell, Atrophy                 | 2     2           2                       2                 2  2         |             
      Acinar Cell, Hyperplasia             |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 |    +                                                           +         |             
      Palate, Epithelium, Hyperplasia      |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                                                   1      |             
      Acinar Cell, Atrophy                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|             
                                           | 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0666%                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |    2        2     2                       2     2                        |             
      Inflammation, Chronic                |    4                                            3                        |             
      Inflammation, Suppurative            |                   2                                                      |             
      Ulcer                                |                                                             1            |             
      Ulcer, Multiple                      |    3                                            3                        |             
      Epithelium, Hyperplasia              |    4        3     3  1                    2     3           3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization                       |                   2                                                      |             
      Necrosis, Focal, Multiple            |                                                                          |             
      Ulcer, Multiple                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  2  3           2  3  2        2  2  2     2  2  2  2  2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       2                                                  2               |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Focal                   |                            2              3           2                  |             
      Hyperplasia, Focal, Multiple         |       2                                                                  |             
      Hypertrophy, Focal                   |          2                                               2           2   |             
      Vacuolization Cytoplasmic, Focal     |       2  2                          2  1              2              2  2|             
      Vacuolization Cytoplasmic            |                   3                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         2                                                |             
      Pars Distalis, Cyst, Multiple        |                                  2                                       |             
      Pars Distalis, Hyperplasia, Focal    |          2           2  2        2     2                                 |             
      Pars Intermedia, Cyst                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          3                                                               |             
      Ultimobranchial Cyst                 |                                        2                                 |             
      C-Cell, Hyperplasia, Focal           |    2                       2                                             |             
      C-Cell, Hyperplasia                  |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|             
                                           | 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0666%                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3  2     2     3     2  2  3  3  2  3        2                        |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                   2      |             
      Bilateral, Cyst                      |                                           3  3        3     3            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                                     2     4      |             
      Bilateral, Cyst                      |                            3                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          3                                                     4         |             
      Hyperplasia, Glandular               |                                        3                                 |             
      Infiltration Cellular, Lipocyte      |                      3                                                   |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2                       2                                         2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             | 2                                         3  4                          2|             
      Mediastinal, Hemorrhage              |                                     4                                    |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                              3                           |             
      Pancreatic, Hyperplasia, Lymphoid    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      3   |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                 3              2           4                           |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                  2  3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|             
                                           | 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0666%                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |       2  3     2  2     2           2     2           2     3  2  2      |             
      Duct, Cyst                           | 2  3  2  3                 2  2     2  3  2  2  2  3  2  2  3        2  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nipple, Hyperkeratosis               |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                         3                                                |             
      Calvarium, Hyperostosis              |                2        3                                            2   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3                                3           4  3        3        2   |             
      Hemorrhage                           |                                     2                       2            |             
      Hemorrhage, Multiple                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     3                                    |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     |                            3                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Submucosa, Pigmentation              | 2  2  2  2  1  1  1  2  2  2        1  1  2  2  2  1  2  2  2  1  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Multiple                    |       3                                                                  |             
      Nephropathy, Chronic                 | 2  3  3  3     2  3  2  2  1        2  2  3  2  3  2  2  2  2  2  2  3  3|             
      Pelvis, Dilatation                   |                         2                                                |             
      Renal Tubule, Mineralization         |             2                 2                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 5| 5| 7| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 2| 2| 3| 8| 1| 2| 2| 2| 0| 1| 3| 4| 3| 5| 9| 1| 3| 3| 4| 3| 3| 3| 3|             
                                           | 0| 8| 9| 9| 6| 9| 9| 9| 9| 9| 2| 6| 0| 6| 0| 9| 5| 6| 0| 0| 1| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0666%                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Pigmentation           |    2  2  1  1     2  2  2  2           2  2  2  2  1  2  2  2  1  2  2  2|             
      Transitional Epithelium, Hyperplasia |          2                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3|            |
                                           | 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.0666%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                         2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                              2                          2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                1         |      4  1.0|
      Basophilic Focus, Multiple           |    2  2  2     2  2  2  2  2     2     2  2  2     2  2  2        1     1|     34  1.9|
      Clear Cell Focus                     |                                                          3               |      3  2.0|
      Degeneration, Multiple               |                               3                                          |      1  3.0|
      Eosinophilic Focus                   |                                        2                 2               |      5  2.0|
      Eosinophilic Focus, Multiple         |                   2                                                      |      3  2.3|
      Hepatodiaphragmatic Nodule           |                2     3     2        3  3           2                     |     10  2.3|
      Hyperplasia, Nodular                 | 2                                                           3            |      3  2.3|
      Inflammation, Granulomatous, Multiple|       2  1  2        2  2  1           2           2  2  1     1         |     20  1.7|
      Mixed Cell Focus                     |                                                                          |      2  2.0|
      Necrosis                             |                                     2                                    |      2  3.0|
      Pigmentation                         | 2                                                                        |      1  2.0|
      Vacuolization Cytoplasmic            | 4                                               3           4            |      5  3.0|
      Bile Duct, Hyperplasia               | 2  2  1  2     1  2  1  2  2        2  2  2        2  1  1  2  1  2  2   |     34  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +        +     +                             +  +     +   |  11        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                3                                                         |      1  3.0|
      Fat, Necrosis, Focal                 |                2        2     2                             3  2     3   |      9  2.2|
      Fat, Necrosis, Focal, Multiple       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus, Multiple           |       2                                                                  |      1  2.0|
      Acinar Cell, Atrophy                 |    2     2        2  3  2                 2           4              2  3|     15  2.3|
      Acinar Cell, Hyperplasia             |       3                                3                 2               |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   2        |
      Palate, Epithelium, Hyperplasia      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3|            |
                                           | 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.0666%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytomegaly                           |                                  2                                       |      1  2.0|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  1.0|
      Acinar Cell, Atrophy                 |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      5  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.5|
      Inflammation, Suppurative            | 3                                                                        |      2  2.5|
      Ulcer                                |                                                             1            |      2  1.0|
      Ulcer, Multiple                      |                                                                          |      2  3.0|
      Epithelium, Hyperplasia              | 1  1     1                          2                    1  2            |     13  2.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                           2                              |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Focal, Multiple            |                                                             2            |      1  2.0|
      Ulcer, Multiple                      |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  2  2  2  2     2  3  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2|     41  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2  2.0|
      Degeneration, Cystic                 |                                                                      4   |      1  4.0|
      Hyperplasia, Focal                   |                         2                                               2|      5  2.2|
      Hyperplasia, Focal, Multiple         |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                2                                3        3               |      6  2.3|
      Vacuolization Cytoplasmic, Focal     |                                                 3                        |      8  2.0|
      Vacuolization Cytoplasmic            |                                                             2            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 2                                                                       2|      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3|            |
                                           | 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.0666%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                   2                                            4         |      3  2.7|
      Pars Distalis, Cyst, Multiple        |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                    3                     |      6  2.2|
      Pars Intermedia, Cyst                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Ultimobranchial Cyst                 |       2                                                                  |      2  2.0|
      C-Cell, Hyperplasia, Focal           |       2  2        2                                                      |      5  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | 3              2           2  2                    3  2              2   |     18  2.4|
      Hyperplasia, Focal                   |                                                                2         |      1  2.0|
      Hyperplasia                          |                                                 2                        |      1  2.0|
      Inflammation, Suppurative            |                                                                   2      |      2  2.0|
      Bilateral, Cyst                      |                      3  2                       3        3  3  2  2      |     11  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        3                       3         |      5  3.0|
      Bilateral, Cyst                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      2  3.5|
      Hyperplasia, Glandular               |                            2                                             |      2  2.5|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |    2        2                    3                 2  2  3               |      9  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythroid Cell, Hyperplasia          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Angiectasis             |                         2                                                |      5  2.6|
      Mediastinal, Hemorrhage              |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3|            |
                                           | 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.0666%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Multiple                       |          2              2  2                                             |      3  2.0|
      Hyperplasia, Lymphoid                |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          3                                                               |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                                             2            |      1  2.0|
      Hematopoietic Cell Proliferation     |                4                                                         |      5  3.0|
      Necrosis                             |                                                 3                        |      1  3.0|
      Pigmentation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |    2  3  3        2  2     2              2     2  3              2     2|     22  2.2|
      Duct, Cyst                           | 3        2  3  2     2  2     2     3  2        2     3  2  3  3  2  2   |     33  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nipple, Hyperkeratosis               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      1  3.0|
      Calvarium, Hyperostosis              |                         2                                                |      4  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          2           2        3     2     2                    3  3      |     13  2.7|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hemorrhage, Multiple                 |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                      2        2  2                       2               |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 6| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 1| 1| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 8| 3|            |
                                           | 3| 1| 1| 1| 1| 3| 2| 2| 2| 2| 5| 3| 0| 5| 5| 3| 2| 5| 5| 5| 1| 1| 3| 3| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0.0666%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Fungus                        | 2        2                                                               |      2  2.0|
      Lumen, Inflammation, Suppurative     | 2        2                                                               |      2  2.0|
      Submucosa, Pigmentation              | 1  2  2  2  2  1  2  2  2  1  1  2     2  2  1  2  2  1  2  1     2  2  2|     46  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Cataract                             |             3                                                            |      1  3.0|
      Retina, Degeneration                 |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct, Multiple                    |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     46  2.2|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      3  2.0|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  3  2  2  2  2  2  2  1  1|     45  1.9|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 8| 6| 6| 7| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.0666%                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |          1  1  1  1                                                      |      4  1.0|
      Basophilic Focus, Multiple           | 1     1              1  1  1                                             |      5  1.0|
      Eosinophilic Focus                   | 2                                                                        |      1  2.0|
      Hepatodiaphragmatic Nodule           |                            3                                             |      1  3.0|
      Inflammation, Granulomatous, Multiple|       2  1                                                               |      2  1.5|
      Mixed Cell Focus                     | 2     1                                                                  |      2  1.5|
      Bile Duct, Hyperplasia               | 1  1  1           1                                                      |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                         +                                                |   1        |
      Pars Distalis, Cyst, Multiple        |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 | 2           2           2                                                |      3  2.0|
      Cyst, Multiple                       |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2     2  1  2  2  2     2  2                                             |      8  1.9|
      Pigmentation                         | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|
      Capsule, Hypertrophy                 |    1     2  2                                                            |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 8| 6| 6| 7| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.0666%                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +        +                                                |   6        |
      Submucosa, Pigmentation              |    1  1  1  1  1        1                                                |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                            3                                             |      1  3.0|
      Nephropathy, Chronic                 | 1     1        2  2     1                                                |      5  1.4|
      Renal Tubule, Dilatation             | 1  1  1  1  1     2                                                      |      6  1.2|
      Renal Tubule, Mineralization         | 2  2  1        2     1  2  1                                             |      7  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|             
                                           | 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0222%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      2                             2     2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2                                2        2     2|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2                                               2            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | 1  2  2  2  2  2  2  2  2  2     2  2        2     2  2        2  2  2  2|             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   | 2                             3                                      2   |             
      Eosinophilic Focus, Multiple         |                                           3                              |             
      Hepatodiaphragmatic Nodule           |          2                    3                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Granulomatous, Multiple|    1     2  1  2  1        2              2  2     2  1  2     1  2  1  1|             
      Mixed Cell Focus                     |                                                                   3     1|             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Vacuolization Cytoplasmic            |       2                                                                  |             
      Bile Duct, Hyperplasia               |    2  1  1     2  2        1  2     1  2     1  2              2  2  1   |             
      Serosa, Fibrosis                     |                                                                         3|             
      Serosa, Inflammation, Granulomatous  |                                                                         3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                          +                 +|             
      Fat, Inflammation, Granulomatous     |                                                       3                  |             
      Fat, Necrosis, Focal                 |                                                       3                 2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                                                                          |             
      Acinar Cell, Atrophy                 |    2           2           3                                   2     2   |             
      Acinar Cell, Hyperplasia             |    3                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer, Multiple                      | 2                                                                        |             
      Epithelium, Hyperplasia              |    3                 2        2              1                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 3                        |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|             
                                           | 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0222%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis, Focal, Multiple            |                                                                          |             
      Ulcer                                | 2                                                                        |             
      Epithelium, Hyperplasia, Focal       |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2        2  2  2|             
      Atrium, Congestion                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                    2           2  1      |             
      Hyperplasia, Focal                   | 2           2  3  2        2                    2                        |             
      Hypertrophy, Focal                   |          2     2  2        2              1                          2  2|             
      Hypertrophy, Focal, Multiple         |       3                                               2                  |             
      Necrosis, Focal, Multiple            | 2                                                                        |             
      Vacuolization Cytoplasmic, Focal     |       2                       2     2        2  2              2         |             
      Vacuolization Cytoplasmic            |                2                                                         |             
      Vacuolization Cytoplasmic, Multiple  |                   2                                                     2|             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Focal                           |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |    2                                                                     |             
      Hyperplasia, Focal                   |    2        2                                2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |          2        2     2                                               3|             
      Pars Distalis, Cyst, Multiple        |                                        2                                 |             
      Pars Distalis, Hyperplasia, Focal    |          2                                                     2     1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |          2        2                 2                                    |             
      C-Cell, Hyperplasia                  |                                                 3     2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3  2                 3     3           2        2  2  2     3        2   |             
      Hyperplasia, Focal                   |                2                                                     2   |             
      Inflammation, Suppurative            | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|             
                                           | 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0222%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Cyst                      |                2                             3                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                                                        |             
      Inflammation, Granulomatous, Multiple|                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Dilatation                           |                                                                          |             
      Hyperplasia, Glandular               |                               2                                         2|             
      Inflammation, Suppurative            |                                                                         3|             
      Cervix, Inflammation, Suppurative    | 4                                                                        |             
      Endometrium, Hyperplasia, Cystic     |                      2                          2                    2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                      +   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |             3        3                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   | 2              2                                         3               |             
      Mediastinal, Pigmentation            |                                                       3                  |             
      Pancreatic, Angiectasis              |                      2                                                   |             
      Renal, Cyst, Multiple                |                               4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                                                                     |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                              2                           |             
      Cyst, Multiple                       |                               3                                          |             
      Hyperplasia, Lymphoid                |                                              2              3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |    3                                                                     |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         | 3        3  3                                                            |             
      Capsule, Fibrosis                    |                                                                         3|             
      Capsule, Hypertrophy                 |                                                                          |             
      Capsule, Inflammation, Granulomatous |                                                                         3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |    2                    2                                2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|             
                                           | 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0222%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 | 3     3  2     2  2  4        2  2  2           2     2  2     2  2      |             
      Duct, Cyst                           | 3  3  3  2  2        4  2  2     2     3  4     3  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                              3                       2   |             
      Parakeratosis                        |                            3                 3                           |             
      Ulcer                                |                            3                 2                           |             
      Nipple, Hyperplasia                  |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                         3                                                |             
      Calvarium, Hyperostosis              |                            2     2                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       3     3                             4                       2      |             
      Embolus Bacterial, Multiple          | 3                                                                        |             
      Hemorrhage                           |    2                                                                     |             
      Inflammation, Multiple, Suppurative  | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial, Multiple          | 2                                                                        |             
      Hemorrhage, Multiple                 |                   2                                                      |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                         2                                                |             
      Infiltration Cellular, Multiple,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Inflammation, Focal, Granulomatous   |             3                                            3               |             
      Inflammation, Multiple, Suppurative  | 3                                                                        |             
      Mineralization, Focal                |                                                          3               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                          3              2|             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
      Lumen, Foreign Body                  |                                                             2            |             
      Lumen, Fungus                        |                                                    2                     |             
      Lumen, Hyperkeratosis                |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 3| 3| 7| 3| 3| 3| 9| 2| 3| 3| 3|             
                                           | 3| 7| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 1| 1| 1| 2| 2| 2| 2| 8| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0222%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                    2        2            |             
      Nasolacrimal Duct, Hemorrhage        | 2                                                                        |             
      Submucosa, Hemorrhage                | 3  2                                                                     |             
      Submucosa, Pigmentation              | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Cataract                             |                                                    2                     |             
      Retina, Degeneration                 |                                                    4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Hemorrhage                           |             3                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                2                                                         |             
      Hydronephrosis                       | 3                                                                        |             
      Infarct                              |                                                    2                     |             
      Inflammation, Suppurative            | 3                                                                        |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 2  2  3  1  1  2  2  2  2  2  2  2  1  2  2  2  2  2  1  2  2  1     2  2|             
      Papilla, Necrosis                    | 4                                                                        |             
      Renal Tubule, Mineralization         |                         2                                                |             
      Renal Tubule, Pigmentation           |    2  1  2  2  2  1  2  2  2  2  2  2  2  2  1  1  2  2  2  1  1  1  2  2|             
      Transitional Epithelium, Hyperplasia | 4                                                                        |             
                                            __________________________________________________________________________|             
   Ureter                                  | M                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           | X                                                                        |             
      Hemorrhage                           | 3                                                                        |             
      Inflammation, Suppurative            | 4                                                                        |             
      Transitional Epithelium, Hyperplasia | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0.0222%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    | 2                                                                        |      5  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                              2  2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           | 2  2  2  2  2     2     2  2  2  1  1  2  2  2  2  3  2  2  2  2     2  2|     41  2.0|
      Clear Cell Focus, Multiple           |                                                                         1|      1  1.0|
      Eosinophilic Focus                   |    3              X  3        2     2                                    |      8  2.4|
      Eosinophilic Focus, Multiple         |       2                                                                  |      2  2.5|
      Hepatodiaphragmatic Nodule           |                                                                      3   |      3  2.7|
      Hyperplasia, Nodular                 |                                                                   3      |      1  3.0|
      Inflammation, Granulomatous, Multiple|    2  2  2  1     2           1  2  3  1        1  1  2  2     1     1   |     30  1.6|
      Mixed Cell Focus                     |                      3                             2                     |      4  2.3|
      Mixed Cell Focus, Multiple           |                                                                3         |      1  3.0|
      Vacuolization Cytoplasmic            |                      3                                         3         |      3  2.7|
      Bile Duct, Hyperplasia               | 1  2  2              2  1  1  1     1  1  1  1     2  2  1  2     3      |     30  1.5|
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
      Serosa, Inflammation, Granulomatous  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                   +        +                        |   6        |
      Fat, Inflammation, Granulomatous     |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |    2                                   2        3                        |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |                         2                                                |      1  2.0|
      Acinar Cell, Atrophy                 |          2           2     2  3                    2              2      |     11  2.2|
      Acinar Cell, Hyperplasia             |                      3  2                    2                           |      4  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                      2                                         2         |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0.0222%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer, Multiple                      |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                      3                          1              4     2   |      8  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  3.0|
      Mineralization                       |                         2                                                |      1  2.0|
      Necrosis, Focal, Multiple            |                      2                                                   |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  2  2  2  2        2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2|     45  2.0|
      Atrium, Congestion                   |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                     X                                    |      4  1.7|
      Hyperplasia, Focal                   |       2                 2     1                       1                  |     10  1.9|
      Hypertrophy, Focal                   |       2                       2                    3           2         |     11  2.0|
      Hypertrophy, Focal, Multiple         |                                                                          |      2  2.5|
      Necrosis, Focal, Multiple            |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     | 1  2                       2     1              1  2  2           2     2|     15  1.8|
      Vacuolization Cytoplasmic            |                2                                                     2   |      3  2.0|
      Vacuolization Cytoplasmic, Multiple  |                                                                          |      2  2.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Focal                           |             2                                                            |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic, Focal          |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                       2                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                                          |      4  2.3|
      Pars Distalis, Cyst, Multiple        |                         2                       2                    2   |      4  2.0|
      Pars Distalis, Hyperplasia, Focal    |                            2              2                          2   |      6  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |             2           2                             2        2         |      7  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0.0222%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                          2               |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Cyst                                 |    2     2           2  2  2  3  2  2           2  3  3     2        2   |     23  2.3|
      Hyperplasia, Focal                   |                         2                       2                        |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Bilateral, Cyst                      |                                           3                              |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  2                                3      |      3  2.3|
      Inflammation, Granulomatous, Multiple|          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                             4            |      1  4.0|
      Dilatation                           |          3                                      3                 3      |      3  3.0|
      Hyperplasia, Glandular               |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Cervix, Inflammation, Suppurative    |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                            3     2                          3            |      6  2.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                +     +                                                   |   3        |
      Inflammation, Suppurative            |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Angiectasis             |                                                                          |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      3  2.3|
      Mediastinal, Pigmentation            |                                                                          |      1  3.0|
      Pancreatic, Angiectasis              |                                                             3            |      2  2.5|
      Renal, Cyst, Multiple                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    2                                                                     |      2  2.5|
      Congestion                           |                2                                                         |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Cyst, Multiple                       |                                     2                                    |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0.0222%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       3                                3                                 |      3  2.7|
      Edema                                |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                3                                                         |      1  3.0|
      Congestion                           |                   2                                                      |      2  2.5|
      Fibrosis, Focal                      |                                                             2            |      1  2.0|
      Hematopoietic Cell Proliferation     |                   2                                                      |      2  2.0|
      Inflammation, Granulomatous          |       3                                               2                  |      2  2.5|
      Pigmentation                         |                   2                       3                              |      5  2.8|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
      Capsule, Hypertrophy                 |                   2                                                      |      1  2.0|
      Capsule, Inflammation, Granulomatous |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      3  2.0|
      Cyst, Multiple                       |                                                    2                     |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |    3  3  3  2        3  2  2  2     2  2           2        2            |     26  2.3|
      Duct, Cyst                           | 2  2  3  2           3     2  2        2  2  2  2           2  3  2  2  2|     36  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      2  2.5|
      Parakeratosis                        |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  2.5|
      Nipple, Hyperplasia                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      1  3.0|
      Calvarium, Hyperostosis              |       2                             2  2                                 |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    3                                                           4         |      6  3.2|
      Embolus Bacterial, Multiple          |                                                                          |      1  3.0|
      Hemorrhage                           |    2                                                                     |      2  2.0|
      Inflammation, Multiple, Suppurative  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0.0222%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Bacterial, Multiple          |                                                                          |      1  2.0|
      Hemorrhage, Multiple                 |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multiple,     |                                                                          |            |
           Histiocyte                      |                                                 2                        |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      2  3.0|
      Inflammation, Multiple, Suppurative  |                                                                          |      1  3.0|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                         2|      3  2.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Squamous                 |                2                                                         |      1  2.0|
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
      Lumen, Fungus                        |                3                                                         |      2  2.5|
      Lumen, Hyperkeratosis                |                                                                          |      1  4.0|
      Lumen, Inflammation, Suppurative     |                3                                                         |      3  2.3|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  2.0|
      Submucosa, Hemorrhage                |                                                                          |      2  2.5|
      Submucosa, Pigmentation              | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  1  1  2  2|     48  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +           +                                   +               |   4        |
      Cataract                             |          4           4                                   4               |      4  3.5|
      Retina, Degeneration                 |          4           4                                   3               |      4  3.8|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                                    |   2        |
      Hemorrhage                           |                                     3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   1        |
      Inflammation, Suppurative            |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          3               |      2  2.5|
      Hydronephrosis                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 2| 2| 2| 2| 2| 3| 6| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0.0222%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                            2     1                                       |      2  1.5|
      Nephropathy, Chronic                 | 2  2  2  2  2        4  2  2  2     2  2  2  2  2  2  2  2  1  3  2  2  2|     46  2.0|
      Papilla, Necrosis                    |                                                                          |      1  4.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           | 2  3  2  2  2        1  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  1|     47  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 7| 7| 8| 8| 6| 6| 7| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0222%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus, Multiple           | 1  1  1  1  1     1  1  1  1                                             |      9  1.0|
      Clear Cell Focus                     |             1                                                            |      1  1.0|
      Inflammation, Granulomatous, Multiple|       1        1     1  1  2                                             |      5  1.2|
      Bile Duct, Hyperplasia               |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +                                                            |   2        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |          3                                                               |      1  3.0|
      Fat, Necrosis, Focal                 |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                            +                                             |   1        |
      Epithelium, Hyperplasia              |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +              +        +                                                |   3        |
      Pars Distalis, Cyst, Multiple        |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |       3        2                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dilatation                           |          2                                                               |      1  2.0|
      Cervix, Abscess                      |             3                                                            |      1  3.0|
      Cervix, Cyst                         |             3                                                            |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2  2  2  2  1  2  2  2  2  2                                             |     10  1.9|
      Pigmentation                         | 2  3  2  2  1  3  2  3  3  2                                             |     10  2.3|
      Capsule, Hypertrophy                 |                   1     1  1                                             |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 7| 7| 8| 8| 6| 6| 7| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0222%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +                                                            |   3        |
      Submucosa, Pigmentation              |    1  1     1                                                            |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  1  2  1  1  1  1     1  2                                             |      9  1.3|
      Renal Tubule, Mineralization         |       1  1  1  1        1  2                                             |      6  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|             
                                           | 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2  2        2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              2                       2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      2  2                                                |             
      Basophilic Focus, Multiple           |    2  2  2  2              2                 2     2  2  2     2  2  2  2|             
      Clear Cell Focus                     |       1              1                          2              2         |             
      Clear Cell Focus, Multiple           |    2                    2                          2                     |             
      Degeneration, Cystic                 |    1                          3                             1           3|             
      Eosinophilic Focus                   |                                        1                                2|             
      Eosinophilic Focus, Multiple         |                   4                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                          2     2     2   |             
      Hyperplasia, Nodular                 |                3  3        1  3           2                              |             
      Inflammation, Granulomatous, Multiple|       2                                                  2               |             
      Mixed Cell Focus                     |    2        3                                         2                  |             
      Mixed Cell Focus, Multiple           |                                                          2               |             
      Vacuolization Cytoplasmic            |                3                 2                                       |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  3  3  2  2  2  2     2  2  2  2  2  2  2  2     3  2  2  3|             
      Centrilobular, Degeneration          |                                                             3            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +              +                          +  +         |             
      Fat, Hemorrhage, Focal               |                                                                          |             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                   3                                                      |             
      Fat, Necrosis, Focal                 |                   3              2                             3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Ectopic Tissue                       |                      2                                                   |             
      Polyarteritis                        |                                                                         2|             
      Acinar Cell, Atrophy                 |       2  2  3     2              2                 2  2  3     3  3      |             
      Acinar Cell, Hyperplasia             |             3        3                                               3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                                                                          |             
      Inflammation, Suppurative            |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|             
                                           | 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               3     3  3                                 |             
      Inflammation, Chronic                |                               3                                          |             
      Ulcer                                |                               2     3  4                                 |             
      Epithelium, Hyperplasia              |                                     2  2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 3  2  2  2  2     2  2  2  2     3        2  2  2  3  2  2  3     2     2|             
      Atrium, Congestion                   |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          2  2                       2     2                       2      |             
      Hyperplasia, Focal                   |                                                       2  2               |             
      Hypertrophy, Focal                   |                                  2        2                    2     2   |             
      Vacuolization Cytoplasmic, Focal     | 2              2                                2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             2                                   2                    2   |             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            | 3                                         3                              |             
      Pars Distalis, Hyperplasia, Focal    |                2              2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |          2        2              2     2                 2               |             
      Follicle, Cyst                       |             3  2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2  2  2                    2           2                     |             
      Cyst                                 |                   2  2                    3           2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|             
                                           | 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                            3                                             |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |             3              3                                             |             
      Inflammation, Suppurative            |       2  2              2     3        3  3        2  3        2  3  3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4           4           2                 3           3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                    2                       3              3     4   |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                             2            |             
      Interstitial Cell, Hyperplasia       | 2        2              2        2  2        2  2     2        2     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Angiectasis             |    3        2                          2                 2     2  2      |             
      Mediastinal, Hyperplasia, Lymphoid   | 3                                                                        |             
      Mediastinal, Pigmentation            |                                  2                          4            |             
      Pancreatic, Angiectasis              |       2                                                                  |             
      Pancreatic, Hyperplasia, Lymphoid    |             2                                                            |             
      Pancreatic, Pigmentation             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst, Multiple                       |          2                                                              3|             
      Hyperplasia, Lymphoid                | 3     3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Edema                                |                                           3                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                2                    3                                    |             
      Hematopoietic Cell Proliferation     |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 6| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 1| 7| 9| 2| 9| 6| 2| 2| 2| 8| 2| 2| 2| 3|             
                                           | 6| 8| 8| 8| 8| 3| 8| 8| 8| 8| 5| 3| 3| 6| 8| 9| 9| 8| 9| 9| 4| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lobular                 |                               1                    2  3        2     3   |             
      Duct, Cyst                           |                                  2                    2        2         |             
      Duct, Hemorrhage                     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteoporosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                  3        3        3                     |             
      Hemorrhage                           |                3              3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis, Focal                   |       2                                                                  |             
      Inflammation, Granulomatous, Multiple|                                                                2         |             
      Inflammation, Suppurative            | 4                                                                        |             
      Alveolar Epithelium, Hyperplasia     |          3                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |       2                                                                  |             
      Lumen, Fungus                        |       2           3           3  3              3  2                    3|             
      Lumen, Inflammation, Suppurative     | 4                             3  2              2  2                    2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                              4                           |             
      Retina, Degeneration                 |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 3  2  2  3  3  2  2  2  1  2  2  2  1  3  1  1  2  3  3  2  1  2  2  3  3|             
      Renal Tubule, Pigmentation           |    1  2  1  1  2  2  2  2  1  1  2  2  2  2  1  1  1  1  1  3  1  1  1  1|             
      Transitional Epithelium, Hyperplasia |          2                             2              2                 1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                      2                          2                        |      5  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    | 2                             2        2           2  2  2     2         |      9  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                         2                                                |      3  2.0|
      Basophilic Focus, Multiple           |    2  2  2  2     2  2     2        2  2     1     2  2  2     2     2  2|     29  2.0|
      Clear Cell Focus                     |             1                                                        1   |      6  1.3|
      Clear Cell Focus, Multiple           |    1  1                                   2              1               |      7  1.6|
      Degeneration, Cystic                 |    1                                   1           1     1  2  1         |     10  1.5|
      Eosinophilic Focus                   | 3     2                 2                                            3   |      6  2.2|
      Eosinophilic Focus, Multiple         |                                                    2                     |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                 1                        |      1  1.0|
      Hepatodiaphragmatic Nodule           | 2                                                                        |      4  2.0|
      Hyperplasia, Nodular                 |                2                                            2            |      7  2.3|
      Inflammation, Granulomatous, Multiple|                                                                          |      2  2.0|
      Mixed Cell Focus                     |                                                    2                     |      4  2.3|
      Mixed Cell Focus, Multiple           |                         1                                                |      2  1.5|
      Vacuolization Cytoplasmic            |          2                          2                    2               |      5  2.2|
      Bile Duct, Hyperplasia               | 3  2  2  2  2     1  2     2  3  2  2  2  2  2  1  2  2  2  3  2  2  2  2|     46  2.1|
      Centrilobular, Degeneration          |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +  +                 +                 +        +      |  10        |
      Fat, Hemorrhage, Focal               |                3  3                                                      |      2  3.0|
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                      3                 3                 3        3      |      7  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                       2        2         |      2  2.0|
      Ectopic Tissue                       |                                                                          |      1  2.0|
      Polyarteritis                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Atrophy                 | 2           2                             2     2  2  2     3  2         |     18  2.3|
      Acinar Cell, Hyperplasia             |             2                                      2                    2|      6  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytomegaly                           |                                                                3         |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      3  3.0|
      Inflammation, Chronic                |          2                                                               |      2  2.5|
      Ulcer                                |                                                                          |      3  3.0|
      Epithelium, Hyperplasia              |                                                 2                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  3  2  2  2  2  3  2  2  3  2  3  3  3  2  2     3  2  2  2  2  3  3  2|     43  2.3|
      Atrium, Congestion                   |                         3                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    | 2                       2  2                                             |      8  2.0|
      Hyperplasia, Focal                   |                                                          2               |      3  2.0|
      Hypertrophy, Focal                   |       2                                                                  |      5  2.0|
      Vacuolization Cytoplasmic, Focal     |    1                 2        2  2  1     3                              |      9  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |          2                                                               |      4  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                           3                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                            2                                         3   |      2  2.5|
      Pars Distalis, Hemorrhage            |          4                                3                              |      4  3.3|
      Pars Distalis, Hyperplasia, Focal    |                         2                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia, Focal           |                               2                          2               |      7  2.0|
      Follicle, Cyst                       |                         3                                               2|      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                             3            |      6  2.2|
      Cyst                                 |                                        4     2        3                  |      7  2.6|
      Cyst, Multiple                       |                   2                       3                              |      2  2.5|
      Hyperplasia, Focal                   |    3                                                                     |      1  3.0|
      Hyperplasia                          |                                     2                 3                  |      2  2.5|
      Inflammation, Chronic                |    3                                                                     |      2  3.0|
      Inflammation, Suppurative            |                                  2                 3           3         |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         3                                                |      1  3.0|
      Inflammation, Chronic                |                                              3                    3      |      4  3.0|
      Inflammation, Suppurative            |    2     3     3  2  2        2  2  3     3  2  3  2                 2   |     24  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   2        2     2                          2  3  2  3   |     12  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          4        3              3           2     4  2     3  4  3  4  2|     16  3.1|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                      2                       2                           |      3  2.0|
      Interstitial Cell, Hyperplasia       | 2  2     2                                                  2  2     2   |     16  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                        3  2     2                        |      3  2.3|
      Mediastinal, Angiectasis             | 2              3        2                                                |      9  2.2|
      Mediastinal, Hyperplasia, Lymphoid   |                                        3                                 |      2  3.0|
      Mediastinal, Pigmentation            |                                                                          |      2  3.0|
      Pancreatic, Angiectasis              | 2                                                                        |      2  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     2                                    |      1  2.0|
      Cyst, Multiple                       |             2                                                            |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                   3                       2                              |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                      3                                      2  2  2  2   |      7  2.3|
      Hematopoietic Cell Proliferation     |                3                                2                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lobular                 |    2     3        1                          2              1            |     10  2.0|
      Duct, Cyst                           |    2                 2              2                 2                  |      7  2.0|
      Duct, Hemorrhage                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                   X                                                      |      1     |
      Epidermis, Hyperplasia               |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteoporosis                         |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    2     2                          3                                    |      6  2.7|
      Hemorrhage                           |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis, Focal                   |                                                                          |      1  2.0|
      Inflammation, Granulomatous, Multiple|                                           3        2                     |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                         2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
      Lumen, Fungus                        | 3                    2                                                  2|     10  2.6|
      Lumen, Inflammation, Suppurative     | 2                    2                                                  2|      9  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 6| 6| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 9| 0| 0| 0| 0| 6| 3| 1| 1| 1| 3| 8| 9| 1| 1| 7| 6| 1| 1| 1| 5| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                    4                     |      1  4.0|
      Nephropathy, Chronic                 | 2  2  2  2  3     1  3  3  3  1  2  3  3  3  2  2  3  3  2  2  2  2  2  2|     49  2.2|
      Renal Tubule, Pigmentation           |    1  1     1     1  1  1  1  1  2  1     1  1  1  1  2  1  2  2  1  2  1|     45  1.4|
      Transitional Epithelium, Hyperplasia |                         1                 2           2                  |      7  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    | 2  2                 2     2                                             |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     | 1  1  1        1     2                                                   |      5  1.2|
      Clear Cell Focus                     |    2  1           1                                                      |      3  1.3|
      Clear Cell Focus, Multiple           |                1        1                                                |      2  1.0|
      Degeneration, Cystic                 |             1                                                            |      1  1.0|
      Hepatodiaphragmatic Nodule, Multiple |                         3                                                |      1  3.0|
      Inflammation, Granulomatous, Multiple| 1  1        1        1  1                                                |      5  1.0|
      Mixed Cell Focus                     |       3                 2                                                |      2  2.5|
      Vacuolization Cytoplasmic            | 1  1  1  1     1  1  1     1                                             |      8  1.0|
      Bile Duct, Hyperplasia               | 2  1  1  1  1  1  1  1  1  2                                             |     10  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +                                                         |   2        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic                | 2  2        2     2  1     2                                             |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |             2                                                            |      1  2.0|
      Hyperplasia, Focal                   |    2                                                                     |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Hyperplasia, Focal    | 3  2           2                                                         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |          3     3        4                                                |      3  3.3|
      Hyperplasia                          |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Suppurative            | 3     2              2                                                   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |    2  2  2  3  2           2                                             |      6  2.2|
      Interstitial Cell, Hyperplasia       | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mediastinal, Hyperplasia, Lymphoid   |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     15 SSAC                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Fibrosis, Focal                      |       2                                                                  |      1  2.0|
      Nephropathy, Chronic                 | 1  1  1  1  1  1  2  1  1  1                                             |     10  1.1|
      Pelvis, Dilatation                   |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|             
                                           | 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Mineralization                       |          3                                                               |             
      Parasite Metazoan                    | 2  2  2     2     2                 2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |       2     3                                            2        2      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Artery, Thrombosis                   |                                                          4               |             
      Wall, Inflammation, Chronic          |                                                          4               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Basophilic Focus                     |          1                                                               |             
      Basophilic Focus, Multiple           |    2                    1                             2                  |             
      Clear Cell Focus                     |                                                       2                 1|             
      Clear Cell Focus, Multiple           |                                           1                              |             
      Degeneration, Cystic                 |             2              2           1        1  2     1  3     1  2   |             
      Eosinophilic Focus                   |    3     2           2              3     3        3  1  1  3     3      |             
      Eosinophilic Focus, Multiple         |                         3  3           2                                3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      2                 2           3     3               |             
      Hyperplasia, Nodular                 |                                  3     2     3     2        2        2   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                   4                 3                                    |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2        2  3        3  1  2  2  3  2  2  2  2  2  2  3        3  2|             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Vein, Thrombosis                     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                    +        +               |             
      Polyarteritis                        |          2                                               4               |             
      Thrombosis, Multiple                 |                                                          4               |             
      Fat, Hemorrhage, Focal               |                                                          4               |             
      Fat, Necrosis, Focal                 |                                                 3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|             
                                           | 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                       3                  |             
      Polyarteritis                        |                         3                                                |             
      Acinar Cell, Atrophy                 |          2  2              3     2           2     2  3  2           3   |             
      Acinar Cell, Hyperplasia             |                         3                                      2        3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              2        3  3     3         |             
      Inflammation, Chronic                | 1                       2  4                          3                  |             
      Mineralization                       |          3                                                               |             
      Ulcer                                |                                                 2        4     4         |             
      Ulcer, Multiple                      |                                              2                           |             
      Epithelium, Hyperplasia              |    3  2  2        2  2  3  4        2  2  3  2        3  3     2  1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                              2                           |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |    3  3  4              3                                                |             
      Polyarteritis                        |                                                          3               |             
      Ulcer                                |                                                                          |             
      Artery, Thrombosis                   |                                                          4               |             
      Mucosa, Pigmentation, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +                                                               |             
      Aorta, Mineralization                |          4                                                               |             
      Mesenteric Artery, Mineralization    |          3                                                               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  3  3  3  2  2     3  2  3  3     2  2  3  3  2  3  2  2  2  2  2  2  3|             
      Mineralization                       |          2                                                               |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  2                                       |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Focal                   |       2                                                                  |             
      Hypertrophy, Focal                   |                                                                      1   |             
      Hypertrophy, Multiple                |                                                       3                  |             
      Vacuolization Cytoplasmic, Focal     |                   3        1        3                                    |             
      Vacuolization Cytoplasmic, Focal,    |                                                                          |             
           Multiple                        |                                                                          |             
      Vacuolization Cytoplasmic            |             1  2                             1     2     1           1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|             
                                           | 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Spindle Cell, Hyperplasia, Focal     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |    2  2              3  2        2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3  3              3                             2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                              3                    2      |             
      Pars Distalis, Hyperplasia, Focal    |                                                                   2      |             
      Pars Intermedia, Cyst                |                                              2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   3                                                      |             
      Artery, Polyarteritis                |                                                          2               |             
      C-Cell, Hyperplasia, Focal           |                      2                       2           2               |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                  2     2  2              2               |             
      Follicle, Degeneration               |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |       4                                                                  |             
      Atrophy                              | 3  3     3              3                                3               |             
      Cyst                                 | 4  4     2                    3        4        3     2                  |             
      Cyst, Multiple                       |       4                                                                  |             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Suppurative            | 4                                                                        |             
      Bilateral, Atrophy                   |                   3        3                       3                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3              3        3                        |             
      Inflammation, Chronic                |          3                             3                                 |             
      Inflammation, Suppurative            | 2     3  3     2     2  3        2           2  2                 3      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            4        2                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3              4  3                          3        4         |             
      Necrosis                             |                                                                          |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|             
                                           | 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Hyperplasia                      |             2                    2                                       |             
      Interstitial Cell, Hyperplasia       |          2     2              2                             2        2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Cyst                          |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      | 3     2                                                                  |             
      Mediastinal, Angiectasis             |                         2                             2                  |             
      Mediastinal, Pigmentation            |                            3                                             |             
      Pancreatic, Angiectasis              |                         3                                                |             
      Pancreatic, Hyperplasia, Lymphoid    | 3                       2                                                |             
      Renal, Angiectasis                   |                                           3        3                     |             
      Renal, Hyperplasia, Lymphoid         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Cyst                                 |                                                    2                     |             
      Hyperplasia, Lymphoid                | 3           2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Edema                                |       3                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |          3                                3                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                              3                           |             
      Pigmentation                         |          3                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |    2  2  3  3     2     3  2                 1     2  3        3  1  1   |             
      Duct, Cyst                           |                                                                2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Hyperostosis              |                                                          3               |             
      Femur, Fibrous Osteodystrophy        |       2  2              2                                                |             
      Maxilla, Fibrous Osteodystrophy      |       2  2              3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 5| 5| 6| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 5| 6| 1| 1| 8| 3| 4| 9| 9| 8| 2| 9| 2| 2| 1| 2| 4| 6| 8| 8| 4| 4| 6| 2|             
                                           | 8| 5| 3| 5| 8| 9| 2| 1| 7| 7| 1| 9| 9| 9| 9| 1| 1| 6| 7| 6| 9| 2| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                2         |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multiple                 |                                                                          |             
      Inflammation, Granulomatous, Multiple|                         2                                                |             
      Mineralization                       |          4                                                               |             
      Alveolus, Pigmentation               |                                                                          |             
      Mediastinum, Polyarteritis, Multiple |                                                          4               |             
      Mediastinum, Thrombosis, Multiple    |                                                          4               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                3                                                         |             
      Lumen, Foreign Body                  |                2                                                         |             
      Lumen, Fungus                        | 3              3  3              2              3  2  3              2   |             
      Lumen, Inflammation, Suppurative     | 3              2  2              2              2     3              2   |             
      Submucosa, Pigmentation              | 1  1  2  2  2     2  2  2  2  1  1  1  2  2  2  1  2  2  2     2     1  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cataract                             |                      3                                                   |             
      Retina, Degeneration                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Hemorrhage                           |                                                          3               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2     2           2                                 |             
      Cyst, Multiple                       |    3  4  3              4                 2                              |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 3  4  4  4  3  3  2  4  4  3  2  2  4  4  4  1  2  3  4  4  2  4  3  3  1|             
      Renal Tubule, Hyperplasia            |       2                                   1                              |             
      Renal Tubule, Pigmentation           | 1  2  2  1  1  1  2  2  1  2     2  1     1  1  1  2  1  1  2  1  1  1  2|             
      Transitional Epithelium, Hyperplasia | 1  2  2  2     2     2  1        1  2  2  2           2     1  1  2  1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                        +                                 |             
      Transitional Epithelium, Hyperplasia |                                        3                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |          1                          3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7|            |
                             DAY ON TEST   | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2|            |
                                           | 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.200%                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  47        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |                         3           2     2                              |      9  2.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Dilatation                           |                               4                                          |      1  4.0|
      Edema                                |                            2                                             |      1  2.0|
      Parasite Metazoan                    |             2                       2              2           2         |      8  2.1|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Artery, Thrombosis                   |                                                                          |      1  4.0|
      Wall, Inflammation, Chronic          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                         1           1                                1   |      4  1.0|
      Basophilic Focus, Multiple           |                                                                          |      3  1.7|
      Clear Cell Focus                     |                                                                          |      2  1.5|
      Clear Cell Focus, Multiple           |                                  1                                      1|      3  1.0|
      Degeneration, Cystic                 | 3  3     3        2        2     2  2  2  3        1  3  2     2     2  2|     24  2.0|
      Eosinophilic Focus                   |             2        1           2                                       |     13  2.2|
      Eosinophilic Focus, Multiple         | 2  2  2  3              3  2              2           3  3           3   |     14  2.6|
      Hematopoietic Cell Proliferation     | 2                                                                        |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4  2.5|
      Hyperplasia, Nodular                 |    2           3              3           2  3  3  3  2                  |     14  2.5|
      Mixed Cell Focus                     |                            3        2                                    |      2  2.5|
      Necrosis                             |                                                                          |      2  3.5|
      Vacuolization Cytoplasmic            |                                        2                                 |      1  2.0|
      Bile Duct, Hyperplasia               |    3  2  2  2  2  3  1  2  2  2     2  2  3  2  3  1  2  2  2     1  2  2|     40  2.1|
      Centrilobular, Degeneration          |                               3                             4            |      2  3.5|
      Centrilobular, Necrosis              |                                                             2            |      1  2.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                         +                 +  +     +   |   9        |
      Polyarteritis                        |                                                                          |      2  3.0|
      Thrombosis, Multiple                 |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7|            |
                             DAY ON TEST   | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2|            |
                                           | 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.200%                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Hemorrhage, Focal               |                                                                3         |      2  3.5|
      Fat, Necrosis, Focal                 |                                           3                          3   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Ectopic Tissue                       |                                     X           2                        |      2  2.0|
      Fibrosis, Focal                      |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Polyarteritis                        |                                           2                              |      2  2.5|
      Acinar Cell, Atrophy                 |                   2  2           2           2                           |     13  2.2|
      Acinar Cell, Hyperplasia             |       3              3  3                                                |      6  2.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |       4        3  2  3  3                 3                       3      |     11  2.9|
      Inflammation, Chronic                |                      4                 4        3     3  3     3  4  2   |     12  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |    3  3        2     3  4              2  2     3     3  3     2  4      |     15  2.9|
      Ulcer, Multiple                      |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |    2  2        2  3  4  4        2  2  3  3     3     4  3     3  3  3  2|     32  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                         3                                                |      1  3.0|
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
      Mineralization                       |                                                                      2  3|      6  3.0|
      Polyarteritis                        |                                                                          |      1  3.0|
      Ulcer                                |    3                                                                     |      1  3.0|
      Artery, Thrombosis                   |                                                                          |      1  4.0|
      Mucosa, Pigmentation, Focal          |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
      Mesenteric Artery, Mineralization    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |       2  2  2        2  2  3     2  3  2  2        2  2  3  2     2  2  2|     40  2.3|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7|            |
                             DAY ON TEST   | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2|            |
                                           | 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.200%                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                      2   |      2  2.0|
      Degeneration, Cystic                 |                                                       4                  |      1  4.0|
      Hyperplasia, Focal                   |                                                 3                        |      2  2.5|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Hypertrophy, Multiple                |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |       1                    2           2     2                 1         |      8  1.9|
      Vacuolization Cytoplasmic, Focal,    |                                                                          |            |
           Multiple                        |          2                                                               |      1  2.0|
      Vacuolization Cytoplasmic            |                2     2        1                 2  2                     |     11  1.5|
      Spindle Cell, Hyperplasia, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hemorrhage                           |                                                                         3|      1  3.0|
      Hyperplasia, Focal                   |       2                 2           3        3        3                  |     10  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |       2                 3              2  4           2  3     3     3  4|     14  2.9|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    | 2              3                             2                 3         |      5  2.4|
      Pars Intermedia, Cyst                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1  3.0|
      Artery, Polyarteritis                |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |                                                                          |      3  2.0|
      C-Cell, Hyperplasia                  |                                           2                              |      1  2.0|
      Follicle, Cyst                       |                                  2                                       |      5  2.0|
      Follicle, Degeneration               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                          |      1  4.0|
      Atrophy                              |                3        3  2           3     3        3     2        3   |     13  2.8|
      Cyst                                 |       4        2     3                             3     3  2  2     3  3|     16  2.9|
      Cyst, Multiple                       |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7|            |
                             DAY ON TEST   | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2|            |
                                           | 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.200%                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |       2                                                                  |      2  2.0|
      Inflammation, Suppurative            |                                                                      2   |      2  3.0|
      Bilateral, Atrophy                   |                                           2                              |      4  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      3  3.0|
      Inflammation, Chronic                |                                                    3                     |      3  3.0|
      Inflammation, Suppurative            |          2           3        3                    3     3     2     2   |     17  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  2     4        3     4  2        3  3              2  4     3        3|     17  3.1|
      Necrosis                             |                                                                4         |      1  4.0|
      Arteriole, Inflammation, Chronic     |                                                          3               |      1  3.0|
      Bilateral, Atrophy                   |                                                             3            |      1  3.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                2                                2  2                     |      5  2.0|
      Interstitial Cell, Hyperplasia       |          2        2  2                       2                 2         |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Myelofibrosis                        |                   2           4                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Cyst                          |                                                    3                     |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      | 3                                                                        |      3  2.7|
      Mediastinal, Angiectasis             |                                                                          |      2  2.0|
      Mediastinal, Pigmentation            | 3                                                           3  3         |      4  3.0|
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    | 3                                                                        |      3  2.7|
      Renal, Angiectasis                   |                                                       4              3   |      4  3.3|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                        3                                 |      1  3.0|
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7|            |
                             DAY ON TEST   | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2|            |
                                           | 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.200%                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis, Focal                      |          3                    3              3        2  3     3  3      |      9  2.9|
      Hematopoietic Cell Proliferation     | 3                                                                        |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |       1  2     2              1  2           1  2     1  2  1            |     23  1.9|
      Duct, Cyst                           |                      3  2                                3  2  2        2|      7  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                      3   |      1  3.0|
      Ulcer                                |                                                                      3   |      1  3.0|
      Epidermis, Hyperplasia               |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calvarium, Hyperostosis              |                                                                          |      1  3.0|
      Femur, Fibrous Osteodystrophy        |                                                                         2|      4  2.0|
      Maxilla, Fibrous Osteodystrophy      |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                       +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                      2                                                   |      2  2.0|
      Hemorrhage                           |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Multiple                 |                                                                         3|      1  3.0|
      Inflammation, Granulomatous, Multiple|                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Alveolus, Pigmentation               |                                                       2                  |      1  2.0|
      Mediastinum, Polyarteritis, Multiple |                                                                          |      1  4.0|
      Mediastinum, Thrombosis, Multiple    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Squamous                 |                                                                2         |      2  2.5|
      Lumen, Foreign Body                  |                                  2                                       |      2  2.0|
      Lumen, Fungus                        |             2           3     3        2                       2        2|     14  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 4| 6| 6| 6| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 7| 5| 6| 6| 6| 7|            |
                             DAY ON TEST   | 6| 8| 5| 8| 3| 9| 3| 3| 9| 3| 5| 5| 8| 2| 3| 6| 0| 3| 3| 3| 0| 0| 1| 8| 2|            |
                                           | 1| 9| 5| 7| 0| 1| 2| 2| 5| 0| 4| 8| 6| 9| 0| 3| 4| 2| 3| 0| 2| 4| 3| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.200%                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lumen, Inflammation, Suppurative     |             2           3     4  2     2                       2        2|     14  2.4|
      Submucosa, Pigmentation              | 1  2  2  2  2  2  1  2  2        2  1  2  2  2  2  2  2  1  2  2  2  2  2|     45  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                                    |   2        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Cyst                                 |                            2           3                 2               |      6  2.2|
      Cyst, Multiple                       |                                                       3           2      |      7  3.0|
      Hydronephrosis                       |       2                                                                  |      1  2.0|
      Nephropathy, Chronic                 | 2  2  4  2  3  3  2  4  4  3  3  3  3  4  4  2  3  3  4  4     4  4  4  4|     49  3.2|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
      Renal Tubule, Pigmentation           | 3  2  1  2  2  1  2  2  1  1     1  1  1  1  1  1  2  1  2     2  1  1  1|     46  1.4|
      Transitional Epithelium, Hyperplasia |       2        2     1  1  1     2     3  2     2     2  1     2     2  1|     30  1.7|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    |          2        2  2  2                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Parasite Metazoan                    | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     | 1                                                                        |      1  1.0|
      Clear Cell Focus                     |                            1                                             |      1  1.0|
      Hemorrhage, Focal                    |                4                                                         |      1  4.0|
      Hepatodiaphragmatic Nodule           |                   3  X                                                   |      2  3.0|
      Inflammation, Granulomatous, Multiple| 1  1  2  1  1     3     1                                                |      7  1.4|
      Necrosis                             |                4                                                         |      1  4.0|
      Vacuolization Cytoplasmic            | 1  1  1  1  1     1     1  1                                             |      8  1.0|
      Bile Duct, Hyperplasia               | 1  1  2  1  2     1  2  1  1                                             |      9  1.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Acinus, Atrophy                      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperplasia              |             1  2                                                         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Serosa, Fibrosis, Focal              |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic                |       2           1  2  1  2                                             |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Hyperplasia, Focal    |             2           1                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      C-Cell, Hyperplasia                  |                            2                                             |      1  2.0|
      Follicle, Cyst                       |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Depletion Cellular                   | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Granuloma                            |                   3                                                      |      1  3.0|
      Inflammation, Suppurative            |       2        2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3                 4        4                                             |      3  3.7|
      Degeneration                         | 3              4                                                         |      2  3.5|
      Necrosis                             |                4                                                         |      1  4.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |             2                                                            |      1  2.0|
      Interstitial Cell, Hyperplasia       |       2  2        2     2  2                                             |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |       2           2        3                                             |      3  2.3|
      Capsule, Hypertrophy                 | 1  1  2  1  2     2     1  1                                             |      8  1.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.200%                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                      X                                                   |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Focal, Granulomatous   | 2        2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Lumen, Fungus                        |                         4                                                |      1  4.0|
      Lumen, Inflammation, Suppurative     |                         3                                                |      1  3.0|
      Submucosa, Pigmentation              | 1  1  1  1        2  1     1                                             |      7  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  2  2  3  3  1  2  3  3  2                                             |     10  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|             
                                           | 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0666%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                               3                                          |             
      Parasite Metazoan                    |          3  2              2                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                               3                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                               3                                          |             
      Parasite Metazoan                    |          2  2           2                 X                 2            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  3                    3                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |       2  2  2              2     2        2           2  2              2|             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |       2                                               2                  |             
      Degeneration, Cystic                 |                      1     1        2                 2              2   |             
      Eosinophilic Focus                   | 3  2  2     2     1  2                                3     3        3   |             
      Eosinophilic Focus, Multiple         |                                                                   2      |             
      Hepatodiaphragmatic Nodule           |                                           3              2               |             
      Hyperplasia, Nodular                 | 3  2           3                    2                          3  2      |             
      Inflammation, Granulomatous, Multiple|                                                       2                  |             
      Mixed Cell Focus                     |                                                       2                 2|             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Vacuolization Cytoplasmic            |                            2                                2  3         |             
      Bile Duct, Hyperplasia               | 3  3  2  2  2  3  2  3  2  2        2  2  2  1  3  2  2  2     3  2  3  2|             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                          +         |             
      Fat, Necrosis, Focal                 |                                                                3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Acinar Cell, Atrophy                 |    3              2  2           2                 2  2     2  2     2  2|             
      Acinar Cell, Hyperplasia             |                                                                          |             
      Acinar Cell, Vacuolization           |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |          2        2                                                      |             
      Infiltration Cellular, Lipocyte      |                                                 1  1  1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|             
                                           | 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0666%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinar Cell, Atrophy                 |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3                 2                             4  3                     |             
      Inflammation, Chronic                |                   3                                                      |             
      Mineralization                       |                            3                                             |             
      Ulcer                                | 2                 2           2                 3           2            |             
      Ulcer, Multiple                      |                                                    3           3         |             
      Epithelium, Hyperplasia              | 3              1  4           3                 2  3        3  3     2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    3           2         |             
      Erosion, Multiple                    |                                                                          |             
      Mineralization                       |                            3                                             |             
      Ulcer                                |                   2                                                      |             
      Ulcer, Multiple                      |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  2  2  3  2  2  2  2  3  2  3     2  2     3  3  2  3  3     3  2  3|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          2  4                                            2               |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Focal                   |                   2                                                      |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     | 2                 2                             2  2              2      |             
      Vacuolization Cytoplasmic            |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                 3           2     2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                         2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Cyst                  |       2                                                                  |             
      Pars Distalis, Hyperplasia, Focal    | 2           2                                         3        2         |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                      2   |             
      C-Cell, Hyperplasia                  |                                  2     2                                 |             
      Follicle, Cyst                       |             3                       2  2                          3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|             
                                           | 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0666%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                      3   |             
      Atrophy                              | 3           2        3  3                                3  2  2     3   |             
      Atrophy, Multiple                    |                                                                          |             
      Autolysis                            |                         3                                                |             
      Cyst                                 | 3           2     3           3     2     2  3  2  2     2  3  2        2|             
      Cyst, Multiple                       |                3                       3              3                  |             
      Hyperplasia                          |    2           3                             2                           |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |    3                                2                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            | 2           2        2     2  2                 3                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                               3              3   |             
      Hyperplasia, Glandular               |                                        3                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                       4  3              2     4  3     4  2|             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      | 2  2                                                                     |             
      Interstitial Cell, Atrophy           |    3              2                                                      |             
      Interstitial Cell, Hyperplasia       |                   2           2                       2        2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                        4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Cyst, Multiple          |                                                    X                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                                   2      |             
      Pancreatic, Angiectasis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|             
                                           | 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0666%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Cyst, Multiple           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |          3                                                               |             
      Renal, Pigmentation                  |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Cyst, Multiple                       |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |          3  2                 3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   3                                                      |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                       3        3     2   |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Inflammation, Granulomatous, Multiple|                                                                          |             
      Necrosis                             |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |             2  3        2     2  2           1        1           2     1|             
      Duct, Cyst                           |             3  3           3           3              2        2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                 3  3                     |             
      Hemorrhage                           |                                              4                 3         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                   2                                                     2|             
      Inflammation, Focal, Granulomatous   |          2                                                               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 2| 2| 5| 6| 6| 6| 2| 5| 3| 8| 9| 2| 3| 5| 7| 2| 2| 4| 1| 2| 2| 2|             
                                           | 1| 9| 9| 9| 9| 7| 7| 7| 7| 9| 8| 2| 7| 5| 9| 7| 7| 9| 9| 9| 7| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0666%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lumen, Foreign Body                  |       2                          2                                   2  3|             
      Lumen, Fungus                        |                               3                 3                    2   |             
      Lumen, Inflammation, Suppurative     |       2                       2  2              2                    2  2|             
      Respiratory Epithelium,              |                                                                          |             
          Hyperkeratosis                   |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                             3            |             
      Septum, Inflammation, Chronic        |                                                                          |             
      Submucosa, Inflammation, Suppurative |                                                                          |             
      Submucosa, Pigmentation              | 2  2  2  2  2  2  2  2  2  2     2     2  2        2        2  2  2     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                          +               |             
      Retina, Degeneration                 |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                                  |             
      Nephropathy, Chronic                 | 2  2  3  2  3  2  4  2  3  4  2  2  1  3  3  1  3  2  3  3  4  3  3  2  2|             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  1     1  2  1  1  1  2  1  2     1  1  1  2  1  2  2  2  2|             
      Transitional Epithelium, Hyperplasia |       2           2        2           1                 2        2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0666%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  3.0|
      Parasite Metazoan                    |             2              2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  3.0|
      Parasite Metazoan                    |    3                    2        2        2     2        2           2  2|     13  2.1|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                     2  3                                 |      4  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                        1  2                              |      2  1.5|
      Basophilic Focus, Multiple           |          2                                                        2      |     11  2.0|
      Clear Cell Focus                     |                                     2                                    |      1  2.0|
      Clear Cell Focus, Multiple           |                                        1                             1   |      4  1.5|
      Degeneration, Cystic                 | 2     2  2           3  2  4        1                 3        1         |     14  2.0|
      Eosinophilic Focus                   |                                     3  2        3        3        2  2   |     15  2.4|
      Eosinophilic Focus, Multiple         |                         3  3              2           3                 3|      6  2.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      2  2.5|
      Hyperplasia, Nodular                 | 3  2           2     3     3  3  2           3     4  3        3        3|     18  2.7|
      Inflammation, Granulomatous, Multiple|                         2                                                |      2  2.0|
      Mixed Cell Focus                     |                                                                          |      2  2.0|
      Mixed Cell Focus, Multiple           |          2                                                               |      1  2.0|
      Vacuolization Cytoplasmic            |             2                                                            |      4  2.3|
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  3  2  3     3  2  2  2  3  3  3  3  2  3  3  2  3  2|     46  2.3|
      Centrilobular, Degeneration          |                   3           3                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +     +           +      |   5        |
      Fat, Necrosis, Focal                 |                                                 3                 3      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                         2|      1  2.0|
      Acinar Cell, Atrophy                 |                         2        2  2        2        2  2  2           2|     18  2.1|
      Acinar Cell, Hyperplasia             |          4  3           3              2                                 |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0666%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Vacuolization           |                                                                          |            |
          Cytoplasmic                      |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytomegaly                           |                         3                                            3   |      4  2.5|
      Infiltration Cellular, Lipocyte      |                               1                          1  1            |      6  1.0|
      Acinar Cell, Atrophy                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                             4            |      5  3.2|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                                                             3            |      6  2.3|
      Ulcer, Multiple                      |                                                                          |      2  3.0|
      Epithelium, Hyperplasia              |    1                 1  1  2  2  1  2  1     1        1  3  3  3  2  2  3|     25  2.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                             3           2|      4  2.5|
      Erosion, Multiple                    |                                              2                           |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
      Ulcer, Multiple                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2     3  2  3     2  2  3  3  2  3     2  3  2  2  2  2     3     3  3  3|     42  2.5|
      Atrium, Thrombosis                   |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                            2                                      2      |      5  2.4|
      Degeneration, Cystic                 |                                                       4                  |      1  4.0|
      Hyperplasia, Focal                   |                                        3  2     2                        |      4  2.3|
      Hypertrophy, Focal                   |                                                             2            |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    2                 2                       2  2              2     2   |     11  2.0|
      Vacuolization Cytoplasmic            |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 2  2  2  3           2  2                                         2      |     11  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0666%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|  47        |
      Hyperplasia                          |             2              3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  | X  3  2        3                 2                                       |      6  2.4|
      Pars Distalis, Hyperplasia, Focal    | 2  3              3           3  2                             2        2|     11  2.4|
      Pars Intermedia, Cyst                |                3                                               2         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                           2              2               |      3  2.0|
      C-Cell, Hyperplasia                  |                      2                                                   |      3  2.0|
      Follicle, Cyst                       |                                        2           2                     |      6  2.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +                                                            |   1        |
      Inflammation, Suppurative            |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  3.0|
      Atrophy                              |    3  2              2                       2  3  3  3     2            |     16  2.6|
      Atrophy, Multiple                    |                                  2                                       |      1  2.0|
      Autolysis                            |                                                                          |      1  3.0|
      Cyst                                 | 3              2     4  2     3  2     2  2     3  3     3               |     24  2.5|
      Cyst, Multiple                       |    3              2                          3              3            |      7  2.9|
      Hyperplasia                          | 2                                                  3                     |      5  2.4|
      Inflammation, Chronic                |                                        3                                 |      1  3.0|
      Inflammation, Suppurative            |                                                          2               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             4  3                                                         |      2  3.5|
      Inflammation, Suppurative            |          2  3  3  4  3  3           2           3  3        2     2      |     17  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                             3  2                          2   |      7  2.4|
      Hyperplasia, Glandular               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             4        2  2        4        3           4  3               |     15  3.1|
      Bilateral, Atrophy                   |                                                 4  3                     |      2  3.5|
      Bilateral, Interstitial Cell,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0666%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Hyperplasia                      |                   2                                                      |      3  2.0|
      Interstitial Cell, Atrophy           |                                                                          |      2  2.5|
      Interstitial Cell, Hyperplasia       | 2           2        2  2     2              2  2  2  2  2  2            |     15  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                                                3         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |          2                                                               |      1  2.0|
      Mediastinal, Angiectasis             |                               3        3                                 |      2  3.0|
      Mediastinal, Cyst, Multiple          |                                                                          |      1     |
      Mediastinal, Hyperplasia, Lymphoid   |          3                                                               |      1  3.0|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Pancreatic, Angiectasis              |                                                 3                       3|      2  3.0|
      Pancreatic, Cyst, Multiple           |                         3                                                |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst, Multiple                       |                         3                 2           2                  |      3  2.3|
      Fibrosis                             |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                      3        4                    3           3     2   |      8  2.9|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic, Lymphoid   |                         1                                                |      1  1.0|
      Inflammation, Granulomatous, Multiple|                         1                                                |      1  1.0|
      Necrosis                             |                                              3                           |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Fibrosis                             |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Hyperplasia, Lobular                 |    1  1  1                                                        2      |     13  1.6|
      Duct, Cyst                           |    2        2        3        3  2           3  2  3  2              2   |     16  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0666%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |             3                                   3                        |      4  3.0|
      Hemorrhage                           |                                              3                           |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                     2                       2            |      4  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                               3                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Foreign Body                  |                                                                         2|      5  2.2|
      Lumen, Fungus                        | 2           3     2     3                             3                 2|      9  2.6|
      Lumen, Inflammation, Suppurative     |             2     2     3     2           2           2                 2|     13  2.1|
      Respiratory Epithelium,              |                                                                          |            |
          Hyperkeratosis                   |                                                       3                  |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  3.0|
      Septum, Inflammation, Chronic        |                               3                                          |      1  3.0|
      Submucosa, Inflammation, Suppurative | 2                                                                        |      1  2.0|
      Submucosa, Pigmentation              | 2     2     2     2  2  2  2  2  2     2  2  2  2  2  2        2  2  2  2|     37  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Retina, Degeneration                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            3                                             |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 9| 4| 3| 3| 3| 3| 0| 8| 3| 3| 2| 3| 3| 3| 3| 3| 1| 2| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 6| 6| 1| 1| 1| 3| 4| 3| 1| 1| 2| 2| 2| 2| 2| 7| 6| 2| 2| 5| 6| 6| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.0666%                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 | 3  2  3  3  4  1  2  3  3  4  3  2  3  2  2  2  3  3  2  3  2  3  2  3  2|     50  2.6|
      Renal Tubule, Pigmentation           | 2  2  2  1  1  1  2  2  2  2  1  1  1  1  1  1  2  2  2  1  1  1  2  2  1|     48  1.5|
      Transitional Epithelium, Hyperplasia |       2     2              2                                             |      9  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.0666%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Clear Cell Focus                     |                            1                                             |      1  1.0|
      Eosinophilic Focus                   |    1        1           1                                                |      3  1.0|
      Hepatodiaphragmatic Nodule           |                      3                                                   |      1  3.0|
      Inflammation, Granulomatous, Multiple|    1  1  1  1        1  1                                                |      6  1.0|
      Vacuolization Cytoplasmic            | 1  1  1  1  2  1  1     1                                                |      8  1.1|
      Bile Duct, Hyperplasia               | 1  1  2  1     1  1        1                                             |      7  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                                                               |   2        |
      Accessory Spleen                     |       2                                                                  |      1  2.0|
      Fat, Hemorrhage, Focal               |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +                                                            |   1        |
      Epithelium, Hyperplasia              |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +                                             |   9        |
      Atrophy                              | 3                       2                                                |      2  2.5|
      Cyst                                 | 3           3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                            +                                             |   1        |
      Atrophy                              |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                   2                                                      |      1  2.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      | 2     2     2     2  2                                                   |      5  2.0|
      Interstitial Cell, Hyperplasia       |    2     2     2        1                                                |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 8| 8| 6| 7| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.0666%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   1        |
      Pancreatic, Hyperplasia, Lymphoid    |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Congestion                           |                2                                                         |      1  2.0|
      Capsule, Hypertrophy                 | 1        1     1  2  2     1                                             |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   1        |
      Cataract                             |       3                                                                  |      1  3.0|
      Retina, Degeneration                 |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 3  2  2  1  2  3  1  1  2  1                                             |     10  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|             
                                           | 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0222%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           2              2              2|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     2                 2        2         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                       1                  |             
      Basophilic Focus, Multiple           |          2           2  2  2     2  2  2  1     2  2     2        2  2  2|             
      Clear Cell Focus                     |                                                                      2   |             
      Clear Cell Focus, Multiple           |                         2                                2              2|             
      Degeneration, Cystic                 |          2        1  1     1              2                              |             
      Eosinophilic Focus                   |          2        2              2                 3                     |             
      Eosinophilic Focus, Multiple         |                      2     2              3  2                           |             
      Hemorrhage                           |                                                                   4      |             
      Hepatodiaphragmatic Nodule           |                         2                 2                              |             
      Hyperplasia, Nodular                 |                               3                                          |             
      Inflammation, Granulomatous, Multiple|                                                                      2   |             
      Mixed Cell Focus, Multiple           |                                                       1                  |             
      Necrosis                             |                                                                   4      |             
      Thrombosis, Multiple                 |                               3                                          |             
      Vacuolization Cytoplasmic            |                   2                                         2            |             
      Bile Duct, Hyperplasia               |    2  2  2  3  2  2  2  2  2  3  2  2  2  2  1  2  2  2  2  1  2  2  2  2|             
      Centrilobular, Degeneration          |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +  +                                   +        +     +  +|             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                                                       2        3         |             
      Fat, Necrosis, Focal                 |                2  2                                   2        3     3  3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               2                                          |             
      Polyarteritis                        |                                                                          |             
      Acinar Cell, Atrophy                 |                            2  3  2        3     2     2  2  2  2  2      |             
      Acinar Cell, Basophilic Focus        |          2                                                        2      |             
      Acinar Cell, Hyperplasia, Focal      |                                                                   3      |             
      Acinar Cell, Hyperplasia             |          3           3        2        3                 3               |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|             
                                           | 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0222%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Cytomegaly                           |                                                                         3|             
      Fibrosis, Focal                      |                            2                                             |             
      Infiltration Cellular, Lipocyte      |       1  1  1  2  2  1     1  1  2     1  2     1     1  2  1  1  1  2  1|             
      Acinar Cell, Atrophy                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             3            |             
      Inflammation, Chronic                |                                                                          |             
      Perforation                          |                                                             4            |             
      Ulcer                                |                                                             2            |             
      Epithelium, Hyperplasia              |             3                 1  1        1  1     3        3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2  2  3  2  2  2  2  3  2  3  2  2  3  3  2  2  3  2  3  2     2  2  3|             
      Atrium, Congestion                   |                                              3                           |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             2                             X                          2   |             
      Hyperplasia, Focal                   |                                  2     2  2                              |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          1                       2                       2  2           2|             
      Vacuolization Cytoplasmic, Focal,    |                                                                          |             
           Multiple                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             2                       2                                3   |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 2              2                    2  2                             2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      Bilateral, C-Cell, Hyperplasia       |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|             
                                           | 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0222%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                          2           2   |             
      Follicle, Cyst                       |                      2                                                   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2        3              2  3     2     2        2  3     3               |             
      Atrophy, Multiple                    |                                           2  2                           |             
      Cyst                                 |    2     3  2  3  3        3  2     2                          2         |             
      Cyst, Multiple                       |                                  2        3                              |             
      Hyperplasia, Focal                   |             3                                                  2         |             
      Inflammation, Chronic                |                         2                                                |             
      Inflammation, Suppurative            |                                  2     2                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2     2           2  3   |             
      Inflammation, Suppurative            |          2     2     2           2        2  2                           |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                       2  2  2  2     2     3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1              3  2  3           2                       4   |             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |    2           2  2                                                      |             
      Interstitial Cell, Hyperplasia       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                                                    2                    2|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Angiectasis              |    3              3                                                      |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                                        3                                 |             
      Cyst, Multiple                       |                            2     2           3                           |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|             
                                           | 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0222%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                         3|             
      Hemorrhage                           |                                                             3            |             
      Hyperplasia, Lymphoid                |       3                 2                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3  3           3  3  3              3               |             
      Fibrosis, Focal                      |                               3                                          |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Capsule, Hypertrophy                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |    2           1  1  2  2        1              1  2           1  1     1|             
      Duct, Cyst                           |          2  4  2                                3  2        3            |             
      Duct, Hemorrhage                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          2                                                               |             
      Dermis, Fibrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Multiple,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                        2                 2               |             
      Inflammation, Suppurative            |                2                                                         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Fungus                        | 4                             3        3     4                           |             
      Lumen, Inflammation, Suppurative     | 4                          3  2        2     3                           |             
      Submucosa, Pigmentation              | 1  1     2  2  2  2  2  2  2  1  2  2     2     2  2  2     2  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 5| 2| 2| 8| 4| 2| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 3| 3| 4| 3| 3| 3|             
                                           | 3| 1| 9| 8| 8| 9| 7| 8| 8| 8| 5| 9| 9| 9| 9| 9| 9| 2| 2| 2| 8| 7| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.0222%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Cataract                             |                                  2                                       |             
      Retina, Degeneration                 |                                  3                                       |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                2                                                         |             
      Cyst, Multiple                       |          2                                                               |             
      Nephropathy, Chronic                 | 1  1  2  4  3  1  1  3  3  2  2  3  2  2  3  3  2  2  2  3  3  2  2  2  2|             
      Renal Tubule, Hyperplasia            |          2                                                               |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           | 1  2     1  1  1  1  2  1  1  2  1  1  1  1     1  1           2  1  1  1|             
      Transitional Epithelium, Hyperplasia |          1  2           2                                1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3|            |
                                           | 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.0222%                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                          2               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |    2                                                                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectopic Tissue                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                                      3   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       2                                                                  |      2  1.5|
      Basophilic Focus, Multiple           |    2     2  2        2  2  2  2     2              1  2  2           2  2|     27  1.9|
      Clear Cell Focus                     |       2                    2                                      2      |      4  2.0|
      Clear Cell Focus, Multiple           |          2                             2                             2   |      6  2.0|
      Degeneration, Cystic                 |    2                       2           1  2                       2      |     10  1.6|
      Eosinophilic Focus                   |          3              2  2                    2        1              2|     10  2.1|
      Eosinophilic Focus, Multiple         |    2        3                             3                       3      |      8  2.5|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                    2                     |      3  2.0|
      Hyperplasia, Nodular                 |                   2                                                      |      2  2.5|
      Inflammation, Granulomatous, Multiple|                                     2                                    |      2  2.0|
      Mixed Cell Focus, Multiple           |                                                    1                     |      2  1.0|
      Necrosis                             |                                                                          |      1  4.0|
      Thrombosis, Multiple                 |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                 1              2         |      4  1.8|
      Bile Duct, Hyperplasia               | 2  2  2  3  3  2  2  3  2  2  2  2  2  2  2  2        2  2           1  2|     44  2.0|
      Centrilobular, Degeneration          |                   3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +     +                       +                     |  11        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                      3     3                                             |      4  2.8|
      Fat, Necrosis, Focal                 |          2           4     3                                             |      9  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
      Polyarteritis                        |                                                                         3|      1  3.0|
      Acinar Cell, Atrophy                 |                      4     2  2  2  2  2  3        2           1  2     2|     21  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3|            |
                                           | 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.0222%                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Basophilic Focus        |                                                                          |      2  2.0|
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      1  3.0|
      Acinar Cell, Hyperplasia             |                         2     3     2                 3           3      |     10  2.7|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytomegaly                           |       3  2        2                             2     2  2              2|      8  2.3|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Infiltration Cellular, Lipocyte      |    1  1  2  2  1  1  1  1     1     1  1  1  1  1  2  2  1     1     1  1|     39  1.3|
      Acinar Cell, Atrophy                 |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                3                                                  3      |      3  3.0|
      Inflammation, Chronic                |                3                                                  3      |      2  3.0|
      Perforation                          |                                                                          |      1  4.0|
      Ulcer                                |                3                                                  2      |      3  2.3|
      Epithelium, Hyperplasia              |          1     3     1     3     1              1                 4  2  2|     16  1.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  2  3  2  2  2  2  3  3  2  3  3  2  2  2  2  2  2  2        3  3  2  2|     46  2.3|
      Atrium, Congestion                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   | 3                 4                                                      |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                               2                          2               |      5  2.0|
      Hyperplasia, Focal                   |                         1        2                 2     3               |      7  2.0|
      Hypertrophy, Focal                   |          2                          2                                    |      2  2.0|
      Vacuolization Cytoplasmic, Focal     | 2        2  2  2                          2                              |     10  1.9|
      Vacuolization Cytoplasmic, Focal,    |                                                                          |            |
           Multiple                        |                   1                 2                                    |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 3                 1  2     2  2                    3                     |      9  2.2|
      Bilateral, Hyperplasia, Focal        |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3|            |
                                           | 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.0222%                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                         2                                                |      1  2.0|
      Pars Distalis, Cyst, Multiple        |                   3                                                      |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |    2  2                    2                          3                  |      9  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                2                                                         |      1  2.0|
      Bilateral, C-Cell, Hyperplasia       |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |                      2                                                   |      3  2.0|
      Follicle, Cyst                       |          2  3                                      2              2      |      5  2.2|
      Follicular Cell, Hyperplasia         |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3        2     2           3                                             |     13  2.5|
      Atrophy, Multiple                    |                                  3                                       |      3  2.3|
      Cyst                                 |       3  2     2                    4              3  3        2  2     3|     18  2.6|
      Cyst, Multiple                       |                   3                             3                        |      4  2.8|
      Hyperplasia, Focal                   |                   3                                                      |      3  2.7|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |       2                                            2                 3   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                      3                                         3         |      6  2.5|
      Inflammation, Suppurative            |          3     2     2  2     3  2           1        2                 2|     15  2.1|
      Epithelium, Hyperplasia              |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2                       3     2                 3                    3|     12  2.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2           3  2        3  2  2                 3                     |     13  2.5|
      Bilateral, Atrophy                   |                                                                3         |      1  3.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                2                          2                              |      5  2.0|
      Interstitial Cell, Hyperplasia       |    2              2              2  2        2                           |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3|            |
                                           | 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.0222%                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Angiectasis             |                            3        3           3                        |      5  2.6|
      Mediastinal, Hyperplasia, Lymphoid   |                         2                                               3|      2  2.5|
      Pancreatic, Angiectasis              |                                                                          |      2  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst, Multiple                       | 2                                                     3        2         |      6  2.3|
      Hyperplasia, Lymphoid                |                            2                                            2|      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                         2|      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |          3                          2                          2     2   |      6  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                              3                           |      7  3.0|
      Fibrosis, Focal                      |             3     3                                3                 3   |      5  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Capsule, Hypertrophy                 |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hyperplasia, Lymphoid                |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lobular                 | 2  1     1              1  1  3              2        2  2  2            |     21  1.5|
      Duct, Cyst                           |       3  2              3        3        2     2     3  2     2  3     2|     17  2.5|
      Duct, Hemorrhage                     |       3                                         4                 3      |      3  3.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Dermis, Fibrosis                     |                                                                   3      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 0| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 1| 8| 3| 3| 3| 6| 4| 8| 3| 3|            |
                                           | 1| 5| 5| 5| 5| 2| 7| 1| 1| 1| 1| 9| 5| 5| 5| 1| 1| 5| 5| 5| 3| 1| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.0222%                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                               2                                3         |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                                                                      2   |      1  2.0|
      Hemorrhage, Focal                    |                                                                      2   |      1  2.0|
      Infiltration Cellular, Multiple,     |                                                                          |            |
           Histiocyte                      |                         2           2                                    |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                2         |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Foreign Body                  |                            2                 2                    2      |      3  2.0|
      Lumen, Fungus                        | 2           3              2                          3  2               |      9  2.9|
      Lumen, Inflammation, Suppurative     | 2  3        2              2                          2  2        2      |     12  2.4|
      Submucosa, Pigmentation              | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  1  2  2|     45  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                         4|      2  3.0|
      Cyst, Multiple                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 2  3  2  3  3  2  2  3  2  3  3  3  2  3  2  1  3  3  3  3  1  3  4  3  3|     50  2.4|
      Renal Tubule, Hyperplasia            |                               2  1                                       |      3  1.7|
      Renal Tubule, Mineralization         |                      2                          3                        |      2  2.5|
      Renal Tubule, Pigmentation           | 1  1  1  2  1  1  2  2  1  2  2  1  1  1  2  1  2  1  1  2              1|     41  1.3|
      Transitional Epithelium, Hyperplasia |                      1           1                 1  1              1   |      9  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 7| 7| 8| 8| 6| 6| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0222%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     |          1                                                               |      1  1.0|
      Clear Cell Focus, Multiple           | 1                                                                        |      1  1.0|
      Eosinophilic Focus                   |                      1                                                   |      1  1.0|
      Eosinophilic Focus, Multiple         | 1                                                                        |      1  1.0|
      Inflammation, Granulomatous, Multiple|          1        1  1  1                                                |      4  1.0|
      Vacuolization Cytoplasmic            | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Bile Duct, Hyperplasia               | 2  1  2  2  1  1  1  2  1  1                                             |     10  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +  +                                             |   2        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                            2                                             |      1  2.0|
      Fat, Necrosis, Focal                 |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |             2           3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |    2  2                    2                                             |      3  2.0|
      Interstitial Cell, Hyperplasia       | 2           2     2     2                                                |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Capsule, Fibrosis, Focal             |                3                                                         |      1  3.0|
      Capsule, Hypertrophy                 | 1        1           2  1  2                                             |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05092-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           O-NITROANISOLE                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:07:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 7| 7| 8| 8| 6| 6| 7| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.0222%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    15 SSAC                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy, Chronic                 | 2  1  1  1  1  1  1  1  2  1                                             |     10  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------