Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1439

TDMS Study 05093-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           P-NITROANILINE


NTP Experiment-Test: 05093-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 21:13:06




       Facility:  Southern Research Institute

       Chemical CAS #:  100-01-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                               9            9                        10           10           
  Early Deaths                                                                                                                      
    Accidently Killed                                  1                                                                            
    Moribund Sacrifice                                16                                      5                                     
    Natural Death                                      4            1                         4                                     
    Drowned                                                                      1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29                                     41                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Clear Cell Focus                                 2 (4%)                                 1 (2%)                                
      Eosinophilic Focus                               2 (4%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                                           1 (10%)                                1 (10%)     
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (10%)                                            
      Inflammation, Granulomatous                      2 (4%)                                                                       
      Mixed Cell Focus                                 2 (4%)                                 6 (12%)                               
      Mixed Cell Focus, Multiple                       1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                                                                       
      Necrosis, Multifocal                                                       2 (20%)                                            
      Vacuolization Cytoplasmic                        2 (4%)                                 1 (2%)                                
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       1 (2%)                    1 (10%)      1 (2%)                                
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                            1 (2%)                                                                       
   Mesentery                                          (8)                                    (2)                                    
      Cyst                                             1 (13%)                                                                      
      Hemorrhage                                       1 (13%)                                                                      
      Fat, Necrosis                                    4 (50%)                                1 (50%)                               
   Pancreas                                           (50)         (10)         (10)         (50)                                   
      Atrophy, Focal                                                1 (10%)                                                         
      Acinus, Atrophy                                  5 (10%)                                4 (8%)                                
      Acinus, Hyperplasia                                                                     2 (4%)                                
      Duct, Dilatation                                 1 (2%)                                 2 (4%)                                
   Stomach, Forestomach                               (50)         (10)         (10)         (50)                                   
      Diverticulum                                                  1 (10%)                                                         
      Hyperplasia                                     23 (46%)                               16 (32%)                               
   Stomach, Glandular                                 (50)         (10)         (10)         (50)                                   
      Erosion                                          2 (4%)                                                                       
      Hyperplasia                                                                             1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tongue                                             (1)                                                                           
      Congestion                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Mineralization                                                                          1 (100%)                              
      Abdominal, Thrombosis                            1 (100%)                                                                     
   Heart                                              (50)         (10)         (10)         (50)                                   
      Mineralization, Multifocal                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (10)         (50)                      (1)          
      Angiectasis                                                                             1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)       2 (20%)                   1 (2%)                                
      Spindle Cell, Hyperplasia                                                               1 (2%)                                
      X-Zone, Infiltration Cellular, Lipocyte                                                 1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (10)         (10)         (50)                      (1)          
      Hyperplasia                                      2 (4%)                                                                       
   Pituitary Gland                                    (48)         (10)         (9)          (50)                      (1)          
      Congestion                                                                                                        1 (100%)    
      Pars Distalis, Hyperplasia                       9 (19%)                               13 (26%)                               
   Thyroid Gland                                      (50)         (10)         (10)         (50)         (10)                      
      Ultimobranchial Cyst                             1 (2%)                                                                       
      Follicle, Cyst                                   3 (6%)                                 2 (4%)                                
      Follicle, Degeneration, Cystic                  17 (34%)      5 (50%)      3 (30%)     22 (44%)      7 (70%)                  
      Follicular Cell, Hyperplasia                     2 (4%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (10)         (10)         (50)                                   
      Abscess                                          1 (2%)                                                                       
      Cyst                                             9 (19%)      2 (20%)      2 (20%)     15 (30%)                               
      Hemorrhage                                       2 (4%)                                                                       
      Mineralization                                                1 (10%)                                                         
      Pigmentation, Hemosiderin                                     1 (10%)                                                         
   Uterus                                             (50)         (10)         (10)         (50)         (10)         (8)          
      Angiectasis                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1 (2%)                                                                       
      Dilatation                                       8 (16%)                               25 (50%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydrometra                                                                 4 (40%)                                2 (25%)     
      Hyperplasia, Cystic                                           1 (10%)      1 (10%)                   1 (10%)                  
      Inflammation, Acute, Suppurative                                                                                  1 (13%)     
      Endometrium, Hyperplasia, Cystic                50 (100%)     9 (90%)      9 (90%)     49 (98%)     10 (100%)     8 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)                                   
      Hypercellularity                                 6 (12%)                                4 (8%)                                
      Hyperplasia                                                                1 (10%)                                            
   Lymph Node                                         (50)         (10)         (10)         (50)                                   
      Iliac, Hyperplasia                               1 (2%)                                                                       
      Mediastinal, Inflammation, Acute, Suppurative    1 (2%)                                                                       
      Renal, Hyperplasia                               1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (9)          (10)         (49)                                   
      Hyperplasia                                      2 (4%)                                                                       
   Lymph Node, Mesenteric                             (50)         (9)          (10)         (47)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Hyperplasia                                      2 (4%)                                                                       
   Spleen                                             (50)         (10)         (10)         (49)         (10)         (10)         
      Atrophy                                                       1 (10%)      1 (10%)                                            
      Congestion                                                                                                        2 (20%)     
      Ectopic Tissue                                                                          1 (2%)                                
      Hematopoietic Cell Proliferation                45 (90%)                   1 (10%)     43 (88%)                   3 (30%)     
      Pigmentation                                     6 (12%)                               23 (47%)                               
      Pigmentation, Hemosiderin                                                                            1 (10%)                  
   Thymus                                             (49)         (10)         (10)         (48)                                   
      Atrophy                                                       1 (10%)      1 (10%)                                            
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (10)         (49)                                   
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)                      
      Congestion                                                    1 (10%)                                                         
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       2 (4%)                                                                       
      Infiltration Cellular, Multifocal, Histiocyte                              1 (10%)                   3 (30%)                  
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Pigmentation                                                                            2 (4%)                                
      Pigmentation, Hemosiderin, Multifocal                                      1 (10%)                   2 (20%)                  
      Pigmentation, Multifocal                                                                             1 (10%)                  
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                 1 (2%)                                
      Pleura, Fibrosis                                                                        1 (2%)                                
      Pleura, Foreign Body                                                                    1 (2%)                                
      Pleura, Pigmentation, Cholesterol                                                       1 (2%)                                
   Nose                                               (50)         (10)         (10)         (50)                                   
      Foreign Body                                    20 (40%)                   1 (10%)     16 (32%)                               
      Fungus                                           1 (2%)                                                                       
      Inflammation, Acute, Suppurative                18 (36%)                               16 (32%)                               
      Glands, Cyst                                     1 (2%)                                                                       
   Trachea                                            (50)         (10)         (10)         (50)                                   
      Inflammation, Subacute                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Pinna, Infarct                                   1 (100%)                                                                     
   Eye                                                (1)                                    (2)                                    
      Cataract                                                                                1 (50%)                               
      Cornea, Inflammation, Subacute                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (10)         (50)                      (1)          
      Casts Protein                                                 4 (40%)      4 (40%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte                              4 (40%)                                            
      Metaplasia, Osseous                                                                     3 (6%)                                
      Nephropathy, Chronic                            31 (62%)                               29 (58%)                               
      Glomerulus, Amyloid Deposition                                1 (10%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Dilatation                         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                               9           10                        10            9           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11                                     12                                     
    Natural Death                                      5                                      5                         1           
    Accidently Killed                                  1                                      1                                     
    Dosing Accident                                    1            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32                                     32                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                      1 (2%)                                                                       
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Jejunum                           (50)         (1)                       (50)         (10)         (9)          
      Hyperplasia                                                                             1 (2%)                                
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                      1 (2%)                                                                       
      Clear Cell Focus                                 1 (2%)                                 1 (2%)                                
      Cyst                                             2 (4%)                                                                       
      Eosinophilic Focus                               3 (6%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    3 (30%)                                1 (10%)     
      Infiltration Cellular, Multifocal, Lymphocyte                                                                     1 (10%)     
      Mineralization                                   1 (2%)                                                                       
      Mineralization, Focal                                                                                1 (10%)                  
      Mixed Cell Focus                                 5 (10%)                                3 (6%)                                
      Mixed Cell Focus, Multiple                                                              1 (2%)                                
      Necrosis, Focal                                  2 (4%)                                 1 (2%)                                
      Necrosis, Multifocal                                                       2 (20%)                                            
      Kupffer Cell, Pigmentation                       4 (8%)                                39 (78%)                               
      Kupffer Cell, Pigmentation, Hemosiderin                                    1 (10%)                   8 (80%)      9 (90%)     
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                                                                   1 (2%)                                
   Mesentery                                          (9)                                    (6)                                    
      Cyst                                                                                    1 (17%)                               
      Hemorrhage                                                                              1 (17%)                               
      Inflammation, Subacute                           1 (11%)                                                                      
      Fat, Necrosis                                    5 (56%)                                5 (83%)                               
   Pancreas                                           (50)         (1)                       (50)         (10)         (10)         
      Acinus, Atrophy                                  3 (6%)                                 2 (4%)                                
      Duct, Cyst                                                                                           1 (10%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Dilatation                                 1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                     10 (20%)                               22 (44%)                               
   Stomach, Glandular                                 (50)         (1)                       (50)         (10)         (10)         
      Artery, Inflammation, Subacute                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)                       (50)         (10)         (10)         
      Inflammation, Subacute                           2 (4%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Epicardium, Inflammation, Acute                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (1)                       (50)         (10)         (10)         
      Accessory Adrenal Cortical Nodule                                                                                 1 (10%)     
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Degeneration, Fatty, Focal                                                                                        1 (10%)     
      Hypertrophy, Focal                               1 (2%)                                 1 (2%)                    1 (10%)     
      Spindle Cell, Hyperplasia                                                               3 (6%)                                
      X-Zone, Infiltration Cellular, Lipocyte          2 (4%)                                 1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                      2 (4%)                                 2 (4%)                                
   Islets, Pancreatic                                 (50)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (48)         (1)                       (48)         (9)          (9)          
      Pars Distalis, Cyst                                                                     1 (2%)                                
      Pars Distalis, Hyperplasia                       8 (17%)                                9 (19%)                               
   Thyroid Gland                                      (50)         (10)                      (50)         (10)         (10)         
      Inflammation, Subacute                           1 (2%)                                                                       
      C-Cell, Hyperplasia, Focal                                                                           2 (20%)                  
      Follicle, Cyst                                   5 (10%)                                5 (10%)                               
      Follicle, Degeneration, Cystic                  19 (38%)      7 (70%)                  20 (40%)      9 (90%)      4 (40%)     
      Follicular Cell, Hyperplasia                     6 (12%)                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (1)          (1)          (48)         (10)         (10)         
      Abscess                                                                                 1 (2%)                                
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                            11 (22%)                   1 (100%)     8 (17%)      1 (10%)                  
      Hemorrhage                                       1 (2%)                                                                       
      Metaplasia, Osseous                                                                     1 (2%)                                
   Uterus                                             (50)         (10)         (8)          (50)         (10)         (10)         
      Dilatation                                      12 (24%)                               19 (38%)                               
      Hydrometra                                                    1 (10%)      1 (13%)                                2 (20%)     
      Inflammation, Subacute                           1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                49 (98%)      9 (90%)      8 (100%)    49 (98%)     10 (100%)     9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (1)                       (50)         (10)         (10)         
      Hypercellularity                                 8 (16%)                               22 (44%)                               
   Lymph Node                                         (50)         (1)                       (50)         (10)         (10)         
      Iliac, Ectasia                                   1 (2%)                                                                       
      Iliac, Hyperplasia                               2 (4%)                                 1 (2%)                                
      Mediastinal, Hyperplasia                         1 (2%)                                 1 (2%)                                
      Pancreatic, Hyperplasia                                                                 1 (2%)                                
      Pancreatic, Pigmentation                                                                1 (2%)                                
      Renal, Hyperplasia                               1 (2%)                                 1 (2%)                                
   Lymph Node, Mandibular                             (50)         (1)                       (47)         (9)          (10)         
      Hyperplasia                                      1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (1)                       (45)         (10)         (10)         
      Hyperplasia                                                                             2 (4%)                                
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                                                                 1 (2%)                                
      Congestion                                                   10 (100%)     7 (70%)                  10 (100%)     9 (90%)     
      Hematopoietic Cell Proliferation                47 (94%)      9 (90%)     10 (100%)    48 (96%)     10 (100%)     9 (90%)     
      Metaplasia, Osseous                                                                     4 (8%)                                
      Pigmentation                                    45 (90%)                               49 (98%)                               
      Pigmentation, Hemosiderin                                     9 (90%)     10 (100%)                 10 (100%)     9 (90%)     
   Thymus                                             (48)         (1)                       (48)         (8)          (10)         
      Pigmentation, Cholesterol                                                               1 (2%)                                
      Mediastinum, Foreign Body                                     1 (100%)                                                        
      Mediastinum, Hemorrhage                                       1 (100%)                                                        
      Mediastinum, Inflammation                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (1)                       (50)         (10)         (10)         
      Rib, Fracture                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Hemorrhage                                       2 (4%)                                 1 (2%)                                
      Hemorrhage, Focal                                                          1 (10%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte                              2 (20%)                                1 (10%)     
      Infiltration Cellular, Multifocal, Histiocyte                 3 (30%)      1 (10%)                   2 (20%)      1 (10%)     
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                 4 (8%)                                
      Pigmentation, Hemosiderin, Multifocal                         3 (30%)      1 (10%)                   2 (20%)      1 (10%)     
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                 3 (6%)                                
      Alveolar Epithelium, Hyperplasia, Focal                                                                           1 (10%)     
      Mediastinum, Foreign Body                        1 (2%)       1 (10%)                                                         
      Mediastinum, Inflammation, Acute, Suppurative    1 (2%)       1 (10%)                                                         
   Nose                                               (50)         (1)                       (50)         (10)         (10)         
      Foreign Body                                    17 (34%)                               10 (20%)                   1 (10%)     
      Inflammation, Acute, Suppurative                12 (24%)                               12 (24%)                   2 (20%)     
      Nasolacrimal Duct, Dilatation                    1 (2%)                                                                       
      Nasolacrimal Duct, Exudate                                                                                        1 (10%)     
      Nasolacrimal Duct, Inflammation, Subacute                                                                         1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                                           
      Cataract                                         1 (100%)                                                                     
   Harderian Gland                                    (10)                                   (7)                                    
      Hyperplasia                                      2 (20%)                                1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (1)                       (50)         (10)         (10)         
      Casts Protein                                                                                        5 (50%)      4 (40%)     
      Infiltration Cellular, Multifocal, Lymphocyte                                                                     2 (20%)     
      Nephropathy, Chronic                            37 (74%)                               28 (56%)                               
      Renal Tubule, Hyperplasia, Focal                                                                     1 (10%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                              10           10                        10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      4                                      4                                     
    Moribund Sacrifice                                13                                     14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                                     32                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Basophilic Focus                                 3 (6%)                                                                       
      Clear Cell Focus                                 6 (12%)                                2 (4%)                                
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Eosinophilic Focus                               8 (16%)                                4 (8%)                                
      Hematopoietic Cell Proliferation                                           1 (10%)                                            
      Hemorrhage                                                                              1 (2%)                                
      Mixed Cell Focus                                 5 (10%)                                9 (18%)                               
      Necrosis, Focal                                                                         4 (8%)                                
      Necrosis, Multifocal                             1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       1 (2%)                                 1 (2%)                                
      Kupffer Cell, Pigmentation, Hemosiderin                                    1 (10%)                                            
   Mesentery                                          (2)                                    (4)                       (1)          
      Fat, Necrosis                                                                           2 (50%)                               
      Fat, Necrosis, Focal                                                                                              1 (100%)    
   Pancreas                                           (50)         (10)         (10)         (50)                                   
      Basophilic Focus                                 2 (4%)                                                                       
      Acinus, Atrophy                                  6 (12%)                                2 (4%)                                
      Duct, Dilatation                                                                        1 (2%)                                
   Stomach, Forestomach                               (50)         (10)         (10)         (50)                      (10)         
      Hyperplasia                                     21 (42%)                   1 (10%)     20 (40%)                   1 (10%)     
      Inflammation, Subacute                                                     1 (10%)                                1 (10%)     
   Stomach, Glandular                                 (50)         (10)         (10)         (50)                      (10)         
      Hyperplasia                                      2 (4%)                                                                       
   Tooth                                              (35)                                   (35)                                   
      Dysplasia                                       35 (100%)                              35 (100%)                              
      Inflammation, Subacute                                                                  1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (10)         (50)                                   
      Inflammation, Subacute                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (10)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Hypertrophy, Focal                               8 (16%)                                8 (16%)                               
      Vacuolization Cytoplasmic, Focal                              1 (10%)                                                         
      Capsule, Accessory Adrenal Cortical Nodule       2 (4%)                                                                       
      Spindle Cell, Hyperplasia                       10 (20%)                               13 (26%)                               
   Adrenal Gland, Medulla                             (50)         (10)         (10)         (50)                                   
      Hyperplasia                                      2 (4%)                                 1 (2%)                                
   Islets, Pancreatic                                 (50)         (10)         (10)         (50)                                   
      Hyperplasia                                      7 (14%)                   1 (10%)      6 (12%)                               
   Parathyroid Gland                                  (49)         (10)         (10)         (47)                                   
      Cyst                                                                       1 (10%)                                            
   Pituitary Gland                                    (48)         (9)          (8)          (47)                                   
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)         (10)         (50)         (10)         (1)          
      Ultimobranchial Cyst                                          1 (10%)                                                         
      Follicle, Cyst                                   9 (18%)                                3 (6%)                                
      Follicle, Degeneration, Cystic                   8 (16%)      2 (20%)      2 (20%)     17 (34%)      3 (30%)      1 (100%)    
      Follicular Cell, Hyperplasia                     2 (4%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)         (10)         (50)                                   
      Granuloma Sperm                                  2 (4%)                                                                       
   Penis                                                                                     (1)                                    
      Developmental Malformation                                                              1 (100%)                              
   Preputial Gland                                    (25)                      (1)          (25)                      (4)          
      Inflammation, Subacute                           5 (20%)                                1 (4%)                                
      Duct, Cyst                                      23 (92%)                   1 (100%)    22 (88%)                   4 (100%)    
   Testes                                             (50)         (10)         (10)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                                                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Mineralization                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)         (10)         (10)         
      Hypercellularity                                 1 (2%)                                10 (20%)                               
   Lymph Node, Mesenteric                             (49)         (8)          (10)         (47)                                   
      Angiectasis                                      1 (2%)                                 3 (6%)                                
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Atrophy                                          1 (2%)                                 1 (2%)                                
      Congestion                                                                                                        1 (10%)     
      Hematopoietic Cell Proliferation                13 (26%)                   2 (20%)     18 (36%)                               
      Pigmentation                                                                            1 (2%)                                
   Thymus                                             (46)         (10)         (10)         (47)                                   
      Cyst                                             1 (2%)                    4 (40%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (10)         (10)         (50)         (1)                       
      Cyst Epithelial Inclusion                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Embolus, Multiple                                                                       1 (2%)                                
      Erythrophagocytosis, Multifocal                                                                      1 (10%)                  
      Hemorrhage, Multifocal                                                                               1 (10%)                  
      Infiltration Cellular, Multifocal, Histiocyte                                                        2 (20%)      3 (30%)     
      Pigmentation, Hemosiderin, Multifocal                                                                1 (10%)      3 (30%)     
      Alveolar Epithelium, Hyperplasia                 5 (10%)                                3 (6%)                                
      Alveolar Epithelium, Hyperplasia, Focal                                                              1 (10%)      1 (10%)     
   Nose                                               (50)         (10)         (10)         (50)                                   
      Foreign Body                                     8 (16%)                   2 (20%)      7 (14%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Fungus                                           1 (2%)                                 3 (6%)                                
      Inflammation, Acute, Suppurative                 8 (16%)                                6 (12%)                               
      Nasolacrimal Duct, Hyperplasia                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                    (1)                                    
      Cornea, Inflammation, Subacute                   1 (100%)                               1 (100%)                              
   Harderian Gland                                    (8)                                    (6)                                    
      Hyperplasia                                      3 (38%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (10)         (50)                                   
      Casts Protein                                                              1 (10%)                                            
      Hydronephrosis                                   1 (2%)                                 1 (2%)                                
      Inflammation, Acute, Suppurative                                                        1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                 1 (2%)                                
      Nephropathy, Chronic                            38 (76%)                               48 (96%)                               
      Cortex, Cyst                                     1 (2%)                                 2 (4%)                                
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Hyperplasia, Multifocal                         1 (10%)      3 (30%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                              10           10                        10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10                                     10                                     
    Natural Death                                      3                                      1                                     
    Drowned                                            1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36                                     39                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)                                   (50)         (10)         (10)         
      Hyperplasia                                                                             1 (2%)                                
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                      1 (2%)                                 2 (4%)                                
      Basophilic Focus                                 2 (4%)                                                                       
      Clear Cell Focus                                 4 (8%)                                 3 (6%)                                
      Clear Cell Focus, Multiple, Two                                                         1 (2%)                                
      Developmental Malformation                                                 1 (10%)                                            
      Eosinophilic Focus                               3 (6%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Inclusion Body Intracytoplasmic                                                         1 (2%)                                
      Mixed Cell Focus                                 5 (10%)                                2 (4%)                                
      Necrosis, Focal                                  2 (4%)                                 3 (6%)                                
      Biliary Tract, Cyst                              1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       8 (16%)                               50 (100%)                              
      Kupffer Cell, Pigmentation, Hemosiderin                                    5 (50%)                  10 (100%)    10 (100%)    
   Mesentery                                          (6)                                    (1)                                    
      Fat, Necrosis                                    3 (50%)                                                                      
   Pancreas                                           (50)                                   (49)         (10)         (10)         
      Basophilic Focus                                 2 (4%)                                 1 (2%)                                
      Eosinophilic Focus                               2 (4%)                                                                       
      Inflammation, Subacute                                                                  1 (2%)                                
      Acinus, Atrophy                                  4 (8%)                                 1 (2%)                                
      Artery, Inflammation, Subacute                   1 (2%)                                                                       
   Stomach, Forestomach                               (50)                      (10)         (50)         (10)         (10)         
      Erosion                                                                                                           1 (10%)     
      Hyperplasia                                     24 (48%)                               18 (36%)                   1 (10%)     
      Inflammation, Subacute                                                                                            1 (10%)     
   Stomach, Glandular                                 (50)                      (10)         (50)         (10)         (10)         
      Erosion                                                                                 1 (2%)                                
      Inflammation, Subacute                                                                                            1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tooth                                              (33)                                   (35)                                   
      Dysplasia                                       33 (100%)                              35 (100%)                              
      Inflammation, Subacute                           1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Abdominal, Aneurysm                                                                     1 (100%)                              
      Abdominal, Hemorrhage                                                                   1 (100%)                              
      Abdominal, Inflammation, Subacute                1 (100%)                                                                     
      Abdominal, Thrombosis                                                                   1 (100%)                              
      Aorta, Inflammation, Subacute                    1 (100%)                                                                     
   Heart                                              (50)                                   (50)         (10)         (10)         
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                                   (50)         (10)         (10)         
      Hypertrophy, Focal                              10 (20%)                               12 (24%)                               
      Necrosis                                                                                1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)                                 1 (2%)                                
      Spindle Cell, Hyperplasia                       10 (20%)                               11 (22%)                               
   Adrenal Gland, Medulla                             (50)                                   (50)         (10)         (10)         
      Necrosis                                                                                1 (2%)                                
   Islets, Pancreatic                                 (50)                                   (49)         (10)         (10)         
      Hyperplasia                                      6 (12%)                                3 (6%)                                
   Parathyroid Gland                                  (49)                                   (50)         (10)         (10)         
      Cyst                                                                                                              1 (10%)     
   Pituitary Gland                                    (48)                                   (45)         (8)          (8)          
      Pars Distalis, Hyperplasia                       1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (50)         (10)                      (50)         (10)         (10)         
      Ultimobranchial Cyst                                                                                 1 (10%)                  
      Follicle, Cyst                                   6 (12%)                                6 (12%)                               
      Follicle, Degeneration, Cystic                  15 (30%)      3 (30%)                  10 (20%)      4 (40%)      4 (40%)     
      Follicle, Foreign Body                                                                  1 (2%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)                                   (50)         (10)         (10)         
      Granuloma Sperm                                  1 (2%)                                 2 (4%)                                
      Necrosis                                                                                1 (2%)                                
   Preputial Gland                                    (27)                      (2)          (19)                      (2)          
      Inflammation, Subacute                           1 (4%)                                 1 (5%)                                
      Duct, Cyst                                      24 (89%)                   2 (100%)    18 (95%)                   2 (100%)    
   Prostate                                           (50)                                   (50)         (10)         (10)         
      Inflammation, Subacute                           1 (2%)                                                                       
   Testes                                             (50)                                   (50)         (10)         (10)         
      Necrosis                                                                                1 (2%)                                
      Seminiferous Tubule, Dilatation                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)         (10)         (10)         
      Hypercellularity                                22 (44%)                               27 (54%)                               
      Hyperplasia                                                   9 (90%)      4 (40%)                  10 (100%)     9 (90%)     
      Necrosis                                                                                1 (2%)                                
      Pigmentation, Hemosiderin                                     8 (80%)      1 (10%)                  10 (100%)     6 (60%)     
   Lymph Node                                         (50)                      (1)          (49)         (10)         (10)         
      Inguinal, Hyperplasia                            1 (2%)                                                                       
   Lymph Node, Mandibular                             (49)                                   (48)         (10)         (9)          
      Congestion                                                                                                        1 (11%)     
   Lymph Node, Mesenteric                             (49)                      (1)          (45)         (10)         (10)         
      Angiectasis                                      3 (6%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                    6 (60%)     10 (100%)                 10 (100%)    10 (100%)    
      Hematopoietic Cell Proliferation                37 (74%)     10 (100%)    10 (100%)    48 (96%)     10 (100%)    10 (100%)    
      Pigmentation                                    46 (92%)                               50 (100%)                              
      Pigmentation, Hemosiderin                                    10 (100%)    10 (100%)                 10 (100%)    10 (100%)    
      Thrombosis                                                                              1 (2%)                                
   Thymus                                             (49)                                   (47)         (8)          (10)         
      Cyst                                                                                                              3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (2)                       (50)         (10)         (10)         
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Inflammation, Focal, Subacute                    1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Edema, Focal                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                                   (50)         (10)         (10)         
      Cranium, Hypertrophy, Focal                      1 (2%)                                                                       
   Skeletal Muscle                                    (2)                                    (1)                                    
      Artery, Inflammation, Subacute                   1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Infiltration Cellular, Multifocal, Histiocyte                 3 (30%)      4 (40%)                   4 (40%)      1 (10%)     
      Pigmentation, Hemosiderin, Multifocal                         3 (30%)      4 (40%)                   4 (40%)      1 (10%)     
      Alveolar Epithelium, Hyperplasia                 5 (10%)                                8 (16%)                               
      Alveolar Epithelium, Hyperplasia, Focal                       1 (10%)                                                         
      Mediastinum, Thrombosis                                                                 1 (2%)                                
   Nose                                               (50)                                   (50)         (10)         (10)         
      Exudate                                                                                                           2 (20%)     
      Foreign Body                                     8 (16%)                                4 (8%)                    1 (10%)     
      Inflammation, Acute, Suppurative                 8 (16%)                                4 (8%)                    1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)                                    (9)                                    
      Hyperplasia                                                                             1 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)                      (50)         (10)         (10)         
      Metaplasia, Osseous                                                                     2 (4%)                                
      Nephropathy, Chronic                            46 (92%)                               39 (78%)                               
      Bowman's Capsule Parietal Layer, Hyperplasia,                                                                                 
           Focal                                                                                           1 (10%)                  
      Cortex, Cyst                                    12 (24%)                                3 (6%)                    2 (20%)     
      Renal Tubule, Dilatation                         1 (2%)                                                                       
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
      Renal Tubule, Hyperplasia, Multifocal                         1 (10%)                                9 (90%)      1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Necrosis                                                                  1 (2%)                                
   Urinary Bladder                                    (50)         (10)                      (50)         (10)         (10)         
      Hemorrhage                                                                              1 (2%)                                
      Artery, Inflammation, Subacute                   1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------