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https://ntp.niehs.nih.gov/go/1439

TDMS Study 05093-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           P-NITROANILINE


NTP Experiment-Test: 05093-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 21:13:06




       Facility:  Southern Research Institute

       Chemical CAS #:  100-01-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                               9            9                        10           10           
  Early Deaths                                                                                                                      
    Accidently Killed                                  1                                                                            
    Moribund Sacrifice                                16                                      5                                     
    Natural Death                                      4            1                         4                                     
    Drowned                                                                      1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29                                     41                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Clear Cell Focus                                 2 (4%)                                 1 (2%)                                
      Eosinophilic Focus                               2 (4%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                                           1 (10%)                                1 (10%)     
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (10%)                                            
      Inflammation, Granulomatous                      2 (4%)                                                                       
      Mixed Cell Focus                                 2 (4%)                                 6 (12%)                               
      Mixed Cell Focus, Multiple                       1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                                                                       
      Necrosis, Multifocal                                                       2 (20%)                                            
      Vacuolization Cytoplasmic                        2 (4%)                                 1 (2%)                                
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       1 (2%)                    1 (10%)      1 (2%)                                
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                            1 (2%)                                                                       
   Mesentery                                          (8)                                    (2)                                    
      Cyst                                             1 (13%)                                                                      
      Hemorrhage                                       1 (13%)                                                                      
      Fat, Necrosis                                    4 (50%)                                1 (50%)                               
   Pancreas                                           (50)         (10)         (10)         (50)                                   
      Atrophy, Focal                                                1 (10%)                                                         
      Acinus, Atrophy                                  5 (10%)                                4 (8%)                                
      Acinus, Hyperplasia                                                                     2 (4%)                                
      Duct, Dilatation                                 1 (2%)                                 2 (4%)                                
   Stomach, Forestomach                               (50)         (10)         (10)         (50)                                   
      Diverticulum                                                  1 (10%)                                                         
      Hyperplasia                                     23 (46%)                               16 (32%)                               
   Stomach, Glandular                                 (50)         (10)         (10)         (50)                                   
      Erosion                                          2 (4%)                                                                       
      Hyperplasia                                                                             1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tongue                                             (1)                                                                           
      Congestion                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Mineralization                                                                          1 (100%)                              
      Abdominal, Thrombosis                            1 (100%)                                                                     
   Heart                                              (50)         (10)         (10)         (50)                                   
      Mineralization, Multifocal                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (10)         (50)                      (1)          
      Angiectasis                                                                             1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)       2 (20%)                   1 (2%)                                
      Spindle Cell, Hyperplasia                                                               1 (2%)                                
      X-Zone, Infiltration Cellular, Lipocyte                                                 1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (10)         (10)         (50)                      (1)          
      Hyperplasia                                      2 (4%)                                                                       
   Pituitary Gland                                    (48)         (10)         (9)          (50)                      (1)          
      Congestion                                                                                                        1 (100%)    
      Pars Distalis, Hyperplasia                       9 (19%)                               13 (26%)                               
   Thyroid Gland                                      (50)         (10)         (10)         (50)         (10)                      
      Ultimobranchial Cyst                             1 (2%)                                                                       
      Follicle, Cyst                                   3 (6%)                                 2 (4%)                                
      Follicle, Degeneration, Cystic                  17 (34%)      5 (50%)      3 (30%)     22 (44%)      7 (70%)                  
      Follicular Cell, Hyperplasia                     2 (4%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (10)         (10)         (50)                                   
      Abscess                                          1 (2%)                                                                       
      Cyst                                             9 (19%)      2 (20%)      2 (20%)     15 (30%)                               
      Hemorrhage                                       2 (4%)                                                                       
      Mineralization                                                1 (10%)                                                         
      Pigmentation, Hemosiderin                                     1 (10%)                                                         
   Uterus                                             (50)         (10)         (10)         (50)         (10)         (8)          
      Angiectasis                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1 (2%)                                                                       
      Dilatation                                       8 (16%)                               25 (50%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hydrometra                                                                 4 (40%)                                2 (25%)     
      Hyperplasia, Cystic                                           1 (10%)      1 (10%)                   1 (10%)                  
      Inflammation, Acute, Suppurative                                                                                  1 (13%)     
      Endometrium, Hyperplasia, Cystic                50 (100%)     9 (90%)      9 (90%)     49 (98%)     10 (100%)     8 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)                                   
      Hypercellularity                                 6 (12%)                                4 (8%)                                
      Hyperplasia                                                                1 (10%)                                            
   Lymph Node                                         (50)         (10)         (10)         (50)                                   
      Iliac, Hyperplasia                               1 (2%)                                                                       
      Mediastinal, Inflammation, Acute, Suppurative    1 (2%)                                                                       
      Renal, Hyperplasia                               1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (9)          (10)         (49)                                   
      Hyperplasia                                      2 (4%)                                                                       
   Lymph Node, Mesenteric                             (50)         (9)          (10)         (47)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Hyperplasia                                      2 (4%)                                                                       
   Spleen                                             (50)         (10)         (10)         (49)         (10)         (10)         
      Atrophy                                                       1 (10%)      1 (10%)                                            
      Congestion                                                                                                        2 (20%)     
      Ectopic Tissue                                                                          1 (2%)                                
      Hematopoietic Cell Proliferation                45 (90%)                   1 (10%)     43 (88%)                   3 (30%)     
      Pigmentation                                     6 (12%)                               23 (47%)                               
      Pigmentation, Hemosiderin                                                                            1 (10%)                  
   Thymus                                             (49)         (10)         (10)         (48)                                   
      Atrophy                                                       1 (10%)      1 (10%)                                            
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (10)         (49)                                   
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)                      
      Congestion                                                    1 (10%)                                                         
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       2 (4%)                                                                       
      Infiltration Cellular, Multifocal, Histiocyte                              1 (10%)                   3 (30%)                  
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Pigmentation                                                                            2 (4%)                                
      Pigmentation, Hemosiderin, Multifocal                                      1 (10%)                   2 (20%)                  
      Pigmentation, Multifocal                                                                             1 (10%)                  
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                 1 (2%)                                
      Pleura, Fibrosis                                                                        1 (2%)                                
      Pleura, Foreign Body                                                                    1 (2%)                                
      Pleura, Pigmentation, Cholesterol                                                       1 (2%)                                
   Nose                                               (50)         (10)         (10)         (50)                                   
      Foreign Body                                    20 (40%)                   1 (10%)     16 (32%)                               
      Fungus                                           1 (2%)                                                                       
      Inflammation, Acute, Suppurative                18 (36%)                               16 (32%)                               
      Glands, Cyst                                     1 (2%)                                                                       
   Trachea                                            (50)         (10)         (10)         (50)                                   
      Inflammation, Subacute                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Pinna, Infarct                                   1 (100%)                                                                     
   Eye                                                (1)                                    (2)                                    
      Cataract                                                                                1 (50%)                               
      Cornea, Inflammation, Subacute                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (10)         (50)                      (1)          
      Casts Protein                                                 4 (40%)      4 (40%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte                              4 (40%)                                            
      Metaplasia, Osseous                                                                     3 (6%)                                
      Nephropathy, Chronic                            31 (62%)                               29 (58%)                               
      Glomerulus, Amyloid Deposition                                1 (10%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Dilatation                         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                               9           10                        10            9           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11                                     12                                     
    Natural Death                                      5                                      5                         1           
    Accidently Killed                                  1                                      1                                     
    Dosing Accident                                    1            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32                                     32                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                      1 (2%)                                                                       
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Jejunum                           (50)         (1)                       (50)         (10)         (9)          
      Hyperplasia                                                                             1 (2%)                                
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                      1 (2%)                                                                       
      Clear Cell Focus                                 1 (2%)                                 1 (2%)                                
      Cyst                                             2 (4%)                                                                       
      Eosinophilic Focus                               3 (6%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    3 (30%)                                1 (10%)     
      Infiltration Cellular, Multifocal, Lymphocyte                                                                     1 (10%)     
      Mineralization                                   1 (2%)                                                                       
      Mineralization, Focal                                                                                1 (10%)                  
      Mixed Cell Focus                                 5 (10%)                                3 (6%)                                
      Mixed Cell Focus, Multiple                                                              1 (2%)                                
      Necrosis, Focal                                  2 (4%)                                 1 (2%)                                
      Necrosis, Multifocal                                                       2 (20%)                                            
      Kupffer Cell, Pigmentation                       4 (8%)                                39 (78%)                               
      Kupffer Cell, Pigmentation, Hemosiderin                                    1 (10%)                   8 (80%)      9 (90%)     
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                                                                   1 (2%)                                
   Mesentery                                          (9)                                    (6)                                    
      Cyst                                                                                    1 (17%)                               
      Hemorrhage                                                                              1 (17%)                               
      Inflammation, Subacute                           1 (11%)                                                                      
      Fat, Necrosis                                    5 (56%)                                5 (83%)                               
   Pancreas                                           (50)         (1)                       (50)         (10)         (10)         
      Acinus, Atrophy                                  3 (6%)                                 2 (4%)                                
      Duct, Cyst                                                                                           1 (10%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Dilatation                                 1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                     10 (20%)                               22 (44%)                               
   Stomach, Glandular                                 (50)         (1)                       (50)         (10)         (10)         
      Artery, Inflammation, Subacute                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)                       (50)         (10)         (10)         
      Inflammation, Subacute                           2 (4%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Epicardium, Inflammation, Acute                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (1)                       (50)         (10)         (10)         
      Accessory Adrenal Cortical Nodule                                                                                 1 (10%)     
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Degeneration, Fatty, Focal                                                                                        1 (10%)     
      Hypertrophy, Focal                               1 (2%)                                 1 (2%)                    1 (10%)     
      Spindle Cell, Hyperplasia                                                               3 (6%)                                
      X-Zone, Infiltration Cellular, Lipocyte          2 (4%)                                 1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                      2 (4%)                                 2 (4%)                                
   Islets, Pancreatic                                 (50)         (1)                       (50)         (10)         (10)         
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (48)         (1)                       (48)         (9)          (9)          
      Pars Distalis, Cyst                                                                     1 (2%)                                
      Pars Distalis, Hyperplasia                       8 (17%)                                9 (19%)                               
   Thyroid Gland                                      (50)         (10)                      (50)         (10)         (10)         
      Inflammation, Subacute                           1 (2%)                                                                       
      C-Cell, Hyperplasia, Focal                                                                           2 (20%)                  
      Follicle, Cyst                                   5 (10%)                                5 (10%)                               
      Follicle, Degeneration, Cystic                  19 (38%)      7 (70%)                  20 (40%)      9 (90%)      4 (40%)     
      Follicular Cell, Hyperplasia                     6 (12%)                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (1)          (1)          (48)         (10)         (10)         
      Abscess                                                                                 1 (2%)                                
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                            11 (22%)                   1 (100%)     8 (17%)      1 (10%)                  
      Hemorrhage                                       1 (2%)                                                                       
      Metaplasia, Osseous                                                                     1 (2%)                                
   Uterus                                             (50)         (10)         (8)          (50)         (10)         (10)         
      Dilatation                                      12 (24%)                               19 (38%)                               
      Hydrometra                                                    1 (10%)      1 (13%)                                2 (20%)     
      Inflammation, Subacute                           1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                49 (98%)      9 (90%)      8 (100%)    49 (98%)     10 (100%)     9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (1)                       (50)         (10)         (10)         
      Hypercellularity                                 8 (16%)                               22 (44%)                               
   Lymph Node                                         (50)         (1)                       (50)         (10)         (10)         
      Iliac, Ectasia                                   1 (2%)                                                                       
      Iliac, Hyperplasia                               2 (4%)                                 1 (2%)                                
      Mediastinal, Hyperplasia                         1 (2%)                                 1 (2%)                                
      Pancreatic, Hyperplasia                                                                 1 (2%)                                
      Pancreatic, Pigmentation                                                                1 (2%)                                
      Renal, Hyperplasia                               1 (2%)                                 1 (2%)                                
   Lymph Node, Mandibular                             (50)         (1)                       (47)         (9)          (10)         
      Hyperplasia                                      1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (1)                       (45)         (10)         (10)         
      Hyperplasia                                                                             2 (4%)                                
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                                                                 1 (2%)                                
      Congestion                                                   10 (100%)     7 (70%)                  10 (100%)     9 (90%)     
      Hematopoietic Cell Proliferation                47 (94%)      9 (90%)     10 (100%)    48 (96%)     10 (100%)     9 (90%)     
      Metaplasia, Osseous                                                                     4 (8%)                                
      Pigmentation                                    45 (90%)                               49 (98%)                               
      Pigmentation, Hemosiderin                                     9 (90%)     10 (100%)                 10 (100%)     9 (90%)     
   Thymus                                             (48)         (1)                       (48)         (8)          (10)         
      Pigmentation, Cholesterol                                                               1 (2%)                                
      Mediastinum, Foreign Body                                     1 (100%)                                                        
      Mediastinum, Hemorrhage                                       1 (100%)                                                        
      Mediastinum, Inflammation                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (1)                       (50)         (10)         (10)         
      Rib, Fracture                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Hemorrhage                                       2 (4%)                                 1 (2%)                                
      Hemorrhage, Focal                                                          1 (10%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte                              2 (20%)                                1 (10%)     
      Infiltration Cellular, Multifocal, Histiocyte                 3 (30%)      1 (10%)                   2 (20%)      1 (10%)     
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                 4 (8%)                                
      Pigmentation, Hemosiderin, Multifocal                         3 (30%)      1 (10%)                   2 (20%)      1 (10%)     
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                 3 (6%)                                
      Alveolar Epithelium, Hyperplasia, Focal                                                                           1 (10%)     
      Mediastinum, Foreign Body                        1 (2%)       1 (10%)                                                         
      Mediastinum, Inflammation, Acute, Suppurative    1 (2%)       1 (10%)                                                         
   Nose                                               (50)         (1)                       (50)         (10)         (10)         
      Foreign Body                                    17 (34%)                               10 (20%)                   1 (10%)     
      Inflammation, Acute, Suppurative                12 (24%)                               12 (24%)                   2 (20%)     
      Nasolacrimal Duct, Dilatation                    1 (2%)                                                                       
      Nasolacrimal Duct, Exudate                                                                                        1 (10%)     
      Nasolacrimal Duct, Inflammation, Subacute                                                                         1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                                           
      Cataract                                         1 (100%)                                                                     
   Harderian Gland                                    (10)                                   (7)                                    
      Hyperplasia                                      2 (20%)                                1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (1)                       (50)         (10)         (10)         
      Casts Protein                                                                                        5 (50%)      4 (40%)     
      Infiltration Cellular, Multifocal, Lymphocyte                                                                     2 (20%)     
      Nephropathy, Chronic                            37 (74%)                               28 (56%)                               
      Renal Tubule, Hyperplasia, Focal                                                                     1 (10%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                              10           10                        10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      4                                      4                                     
    Moribund Sacrifice                                13                                     14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                                     32                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Basophilic Focus                                 3 (6%)                                                                       
      Clear Cell Focus                                 6 (12%)                                2 (4%)                                
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Eosinophilic Focus                               8 (16%)                                4 (8%)                                
      Hematopoietic Cell Proliferation                                           1 (10%)                                            
      Hemorrhage                                                                              1 (2%)                                
      Mixed Cell Focus                                 5 (10%)                                9 (18%)                               
      Necrosis, Focal                                                                         4 (8%)                                
      Necrosis, Multifocal                             1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       1 (2%)                                 1 (2%)                                
      Kupffer Cell, Pigmentation, Hemosiderin                                    1 (10%)                                            
   Mesentery                                          (2)                                    (4)                       (1)          
      Fat, Necrosis                                                                           2 (50%)                               
      Fat, Necrosis, Focal                                                                                              1 (100%)    
   Pancreas                                           (50)         (10)         (10)         (50)                                   
      Basophilic Focus                                 2 (4%)                                                                       
      Acinus, Atrophy                                  6 (12%)                                2 (4%)                                
      Duct, Dilatation                                                                        1 (2%)                                
   Stomach, Forestomach                               (50)         (10)         (10)         (50)                      (10)         
      Hyperplasia                                     21 (42%)                   1 (10%)     20 (40%)                   1 (10%)     
      Inflammation, Subacute                                                     1 (10%)                                1 (10%)     
   Stomach, Glandular                                 (50)         (10)         (10)         (50)                      (10)         
      Hyperplasia                                      2 (4%)                                                                       
   Tooth                                              (35)                                   (35)                                   
      Dysplasia                                       35 (100%)                              35 (100%)                              
      Inflammation, Subacute                                                                  1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (10)         (50)                                   
      Inflammation, Subacute                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (10)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Hypertrophy, Focal                               8 (16%)                                8 (16%)                               
      Vacuolization Cytoplasmic, Focal                              1 (10%)                                                         
      Capsule, Accessory Adrenal Cortical Nodule       2 (4%)                                                                       
      Spindle Cell, Hyperplasia                       10 (20%)                               13 (26%)                               
   Adrenal Gland, Medulla                             (50)         (10)         (10)         (50)                                   
      Hyperplasia                                      2 (4%)                                 1 (2%)                                
   Islets, Pancreatic                                 (50)         (10)         (10)         (50)                                   
      Hyperplasia                                      7 (14%)                   1 (10%)      6 (12%)                               
   Parathyroid Gland                                  (49)         (10)         (10)         (47)                                   
      Cyst                                                                       1 (10%)                                            
   Pituitary Gland                                    (48)         (9)          (8)          (47)                                   
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)         (10)         (50)         (10)         (1)          
      Ultimobranchial Cyst                                          1 (10%)                                                         
      Follicle, Cyst                                   9 (18%)                                3 (6%)                                
      Follicle, Degeneration, Cystic                   8 (16%)      2 (20%)      2 (20%)     17 (34%)      3 (30%)      1 (100%)    
      Follicular Cell, Hyperplasia                     2 (4%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)         (10)         (50)                                   
      Granuloma Sperm                                  2 (4%)                                                                       
   Penis                                                                                     (1)                                    
      Developmental Malformation                                                              1 (100%)                              
   Preputial Gland                                    (25)                      (1)          (25)                      (4)          
      Inflammation, Subacute                           5 (20%)                                1 (4%)                                
      Duct, Cyst                                      23 (92%)                   1 (100%)    22 (88%)                   4 (100%)    
   Testes                                             (50)         (10)         (10)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                                                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Mineralization                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)         (10)         (10)         
      Hypercellularity                                 1 (2%)                                10 (20%)                               
   Lymph Node, Mesenteric                             (49)         (8)          (10)         (47)                                   
      Angiectasis                                      1 (2%)                                 3 (6%)                                
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Atrophy                                          1 (2%)                                 1 (2%)                                
      Congestion                                                                                                        1 (10%)     
      Hematopoietic Cell Proliferation                13 (26%)                   2 (20%)     18 (36%)                               
      Pigmentation                                                                            1 (2%)                                
   Thymus                                             (46)         (10)         (10)         (47)                                   
      Cyst                                             1 (2%)                    4 (40%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (10)         (10)         (50)         (1)                       
      Cyst Epithelial Inclusion                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Embolus, Multiple                                                                       1 (2%)                                
      Erythrophagocytosis, Multifocal                                                                      1 (10%)                  
      Hemorrhage, Multifocal                                                                               1 (10%)                  
      Infiltration Cellular, Multifocal, Histiocyte                                                        2 (20%)      3 (30%)     
      Pigmentation, Hemosiderin, Multifocal                                                                1 (10%)      3 (30%)     
      Alveolar Epithelium, Hyperplasia                 5 (10%)                                3 (6%)                                
      Alveolar Epithelium, Hyperplasia, Focal                                                              1 (10%)      1 (10%)     
   Nose                                               (50)         (10)         (10)         (50)                                   
      Foreign Body                                     8 (16%)                   2 (20%)      7 (14%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Fungus                                           1 (2%)                                 3 (6%)                                
      Inflammation, Acute, Suppurative                 8 (16%)                                6 (12%)                               
      Nasolacrimal Duct, Hyperplasia                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                    (1)                                    
      Cornea, Inflammation, Subacute                   1 (100%)                               1 (100%)                              
   Harderian Gland                                    (8)                                    (6)                                    
      Hyperplasia                                      3 (38%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (10)         (50)                                   
      Casts Protein                                                              1 (10%)                                            
      Hydronephrosis                                   1 (2%)                                 1 (2%)                                
      Inflammation, Acute, Suppurative                                                        1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                 1 (2%)                                
      Nephropathy, Chronic                            38 (76%)                               48 (96%)                               
      Cortex, Cyst                                     1 (2%)                                 2 (4%)                                
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Hyperplasia, Multifocal                         1 (10%)      3 (30%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                              10           10                        10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10                                     10                                     
    Natural Death                                      3                                      1                                     
    Drowned                                            1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36                                     39                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)                                   (50)         (10)         (10)         
      Hyperplasia                                                                             1 (2%)                                
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Angiectasis                                      1 (2%)                                 2 (4%)                                
      Basophilic Focus                                 2 (4%)                                                                       
      Clear Cell Focus                                 4 (8%)                                 3 (6%)                                
      Clear Cell Focus, Multiple, Two                                                         1 (2%)                                
      Developmental Malformation                                                 1 (10%)                                            
      Eosinophilic Focus                               3 (6%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Inclusion Body Intracytoplasmic                                                         1 (2%)                                
      Mixed Cell Focus                                 5 (10%)                                2 (4%)                                
      Necrosis, Focal                                  2 (4%)                                 3 (6%)                                
      Biliary Tract, Cyst                              1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       8 (16%)                               50 (100%)                              
      Kupffer Cell, Pigmentation, Hemosiderin                                    5 (50%)                  10 (100%)    10 (100%)    
   Mesentery                                          (6)                                    (1)                                    
      Fat, Necrosis                                    3 (50%)                                                                      
   Pancreas                                           (50)                                   (49)         (10)         (10)         
      Basophilic Focus                                 2 (4%)                                 1 (2%)                                
      Eosinophilic Focus                               2 (4%)                                                                       
      Inflammation, Subacute                                                                  1 (2%)                                
      Acinus, Atrophy                                  4 (8%)                                 1 (2%)                                
      Artery, Inflammation, Subacute                   1 (2%)                                                                       
   Stomach, Forestomach                               (50)                      (10)         (50)         (10)         (10)         
      Erosion                                                                                                           1 (10%)     
      Hyperplasia                                     24 (48%)                               18 (36%)                   1 (10%)     
      Inflammation, Subacute                                                                                            1 (10%)     
   Stomach, Glandular                                 (50)                      (10)         (50)         (10)         (10)         
      Erosion                                                                                 1 (2%)                                
      Inflammation, Subacute                                                                                            1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tooth                                              (33)                                   (35)                                   
      Dysplasia                                       33 (100%)                              35 (100%)                              
      Inflammation, Subacute                           1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Abdominal, Aneurysm                                                                     1 (100%)                              
      Abdominal, Hemorrhage                                                                   1 (100%)                              
      Abdominal, Inflammation, Subacute                1 (100%)                                                                     
      Abdominal, Thrombosis                                                                   1 (100%)                              
      Aorta, Inflammation, Subacute                    1 (100%)                                                                     
   Heart                                              (50)                                   (50)         (10)         (10)         
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                                   (50)         (10)         (10)         
      Hypertrophy, Focal                              10 (20%)                               12 (24%)                               
      Necrosis                                                                                1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)                                 1 (2%)                                
      Spindle Cell, Hyperplasia                       10 (20%)                               11 (22%)                               
   Adrenal Gland, Medulla                             (50)                                   (50)         (10)         (10)         
      Necrosis                                                                                1 (2%)                                
   Islets, Pancreatic                                 (50)                                   (49)         (10)         (10)         
      Hyperplasia                                      6 (12%)                                3 (6%)                                
   Parathyroid Gland                                  (49)                                   (50)         (10)         (10)         
      Cyst                                                                                                              1 (10%)     
   Pituitary Gland                                    (48)                                   (45)         (8)          (8)          
      Pars Distalis, Hyperplasia                       1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (50)         (10)                      (50)         (10)         (10)         
      Ultimobranchial Cyst                                                                                 1 (10%)                  
      Follicle, Cyst                                   6 (12%)                                6 (12%)                               
      Follicle, Degeneration, Cystic                  15 (30%)      3 (30%)                  10 (20%)      4 (40%)      4 (40%)     
      Follicle, Foreign Body                                                                  1 (2%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)                                   (50)         (10)         (10)         
      Granuloma Sperm                                  1 (2%)                                 2 (4%)                                
      Necrosis                                                                                1 (2%)                                
   Preputial Gland                                    (27)                      (2)          (19)                      (2)          
      Inflammation, Subacute                           1 (4%)                                 1 (5%)                                
      Duct, Cyst                                      24 (89%)                   2 (100%)    18 (95%)                   2 (100%)    
   Prostate                                           (50)                                   (50)         (10)         (10)         
      Inflammation, Subacute                           1 (2%)                                                                       
   Testes                                             (50)                                   (50)         (10)         (10)         
      Necrosis                                                                                1 (2%)                                
      Seminiferous Tubule, Dilatation                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)         (10)         (10)         
      Hypercellularity                                22 (44%)                               27 (54%)                               
      Hyperplasia                                                   9 (90%)      4 (40%)                  10 (100%)     9 (90%)     
      Necrosis                                                                                1 (2%)                                
      Pigmentation, Hemosiderin                                     8 (80%)      1 (10%)                  10 (100%)     6 (60%)     
   Lymph Node                                         (50)                      (1)          (49)         (10)         (10)         
      Inguinal, Hyperplasia                            1 (2%)                                                                       
   Lymph Node, Mandibular                             (49)                                   (48)         (10)         (9)          
      Congestion                                                                                                        1 (11%)     
   Lymph Node, Mesenteric                             (49)                      (1)          (45)         (10)         (10)         
      Angiectasis                                      3 (6%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                    6 (60%)     10 (100%)                 10 (100%)    10 (100%)    
      Hematopoietic Cell Proliferation                37 (74%)     10 (100%)    10 (100%)    48 (96%)     10 (100%)    10 (100%)    
      Pigmentation                                    46 (92%)                               50 (100%)                              
      Pigmentation, Hemosiderin                                    10 (100%)    10 (100%)                 10 (100%)    10 (100%)    
      Thrombosis                                                                              1 (2%)                                
   Thymus                                             (49)                                   (47)         (8)          (10)         
      Cyst                                                                                                              3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (2)                       (50)         (10)         (10)         
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Inflammation, Focal, Subacute                    1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Edema, Focal                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                                   (50)         (10)         (10)         
      Cranium, Hypertrophy, Focal                      1 (2%)                                                                       
   Skeletal Muscle                                    (2)                                    (1)                                    
      Artery, Inflammation, Subacute                   1 (50%)                                                                      
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Infiltration Cellular, Multifocal, Histiocyte                 3 (30%)      4 (40%)                   4 (40%)      1 (10%)     
      Pigmentation, Hemosiderin, Multifocal                         3 (30%)      4 (40%)                   4 (40%)      1 (10%)     
      Alveolar Epithelium, Hyperplasia                 5 (10%)                                8 (16%)                               
      Alveolar Epithelium, Hyperplasia, Focal                       1 (10%)                                                         
      Mediastinum, Thrombosis                                                                 1 (2%)                                
   Nose                                               (50)                                   (50)         (10)         (10)         
      Exudate                                                                                                           2 (20%)     
      Foreign Body                                     8 (16%)                                4 (8%)                    1 (10%)     
      Inflammation, Acute, Suppurative                 8 (16%)                                4 (8%)                    1 (10%)     
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)                                    (9)                                    
      Hyperplasia                                                                             1 (11%)                               
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)                      (50)         (10)         (10)         
      Metaplasia, Osseous                                                                     2 (4%)                                
      Nephropathy, Chronic                            46 (92%)                               39 (78%)                               
      Bowman's Capsule Parietal Layer, Hyperplasia,                                                                                 
           Focal                                                                                           1 (10%)                  
      Cortex, Cyst                                    12 (24%)                                3 (6%)                    2 (20%)     
      Renal Tubule, Dilatation                         1 (2%)                                                                       
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
      Renal Tubule, Hyperplasia, Multifocal                         1 (10%)                                9 (90%)      1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05093-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:06  
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         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
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URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Necrosis                                                                  1 (2%)                                
   Urinary Bladder                                    (50)         (10)                      (50)         (10)         (10)         
      Hemorrhage                                                                              1 (2%)                                
      Artery, Inflammation, Subacute                   1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
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