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TDMS Study 05093-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           P-NITROANILINE


NTP Experiment-Test: 05093-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 21:13:10




       Facility:  Southern Research Institute

       Chemical CAS #:  100-01-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                               9            9                        10           10           
  Early Deaths                                                                                                                      
    Accidently Killed                                  1                                                                            
    Moribund Sacrifice                                16                                      5                                     
    Natural Death                                      4            1                         4                                     
    Drowned                                                                      1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29                                     41                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (49)         (10)         (9)          (50)                                   
   Intestine Small, Duodenum                          (50)         (10)         (10)         (50)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Ileum                             (50)         (9)          (10)         (50)                                   
   Intestine Small, Jejunum                           (50)         (10)         (10)         (50)                                   
      Adenocarcinoma                                                                          2 (4%)                                
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma                         7 (14%)                   1 (10%)      6 (12%)                               
      Hepatocellular Adenoma                           9 (18%)                   1 (10%)      9 (18%)                   1 (10%)     
      Hepatocellular Adenoma, Multiple, Two            3 (6%)                                 1 (2%)                                
      Hepatocellular Adenoma, Multiple, Three          1 (2%)                                 2 (4%)                                
      Hepatocholangiocarcinoma                                                                1 (2%)                                
   Mesentery                                          (8)                                    (2)                                    
      Sarcoma                                          1 (13%)                                                                      
   Pancreas                                           (50)         (10)         (10)         (50)                                   
   Salivary Glands                                    (50)         (10)         (10)         (50)                                   
   Stomach, Forestomach                               (50)         (10)         (10)         (50)                                   
      Squamous Cell Papilloma                          3 (6%)                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (10)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (10)         (50)                      (1)          
      Spindle Cell, Adenoma                                                                   1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (10)         (10)         (50)                      (1)          
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                                                                 1 (2%)                                
   Islets, Pancreatic                                 (50)         (10)         (10)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (48)         (10)         (9)          (50)                      (1)          
      Pars Distalis, Adenoma                           4 (8%)                                 3 (6%)                                
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (10)         (10)         (50)         (10)                      
      Follicular Cell, Adenoma                                                                3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (10)         (10)         (50)                                   
      Teratoma Benign                                  1 (2%)                                                                       
      Granulosa Cell, Adenoma                          1 (2%)                                                                       
   Uterus                                             (50)         (10)         (10)         (50)         (10)         (8)          
      Adenocarcinoma                                   1 (2%)                                                                       
      Polyp Stromal                                                                           3 (6%)                                
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)                                   
   Lymph Node                                         (50)         (10)         (10)         (50)                                   
      Mediastinal, Osteosarcoma, Metastatic, Bone      1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (9)          (10)         (49)                                   
   Lymph Node, Mesenteric                             (50)         (9)          (10)         (47)                                   
   Spleen                                             (50)         (10)         (10)         (49)         (10)         (10)         
      Hemangiosarcoma                                                                         1 (2%)                                
   Thymus                                             (49)         (10)         (10)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (10)         (10)         (50)         (1)          (1)          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (10)         (50)                                   
      Osteosarcoma                                     1 (2%)                                 1 (2%)                                
   Skeletal Muscle                                    (2)                                                                           
      Carcinoma, Metastatic, Harderian Gland           1 (50%)                                                                      
      Osteosarcoma, Metastatic, Bone                   1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (10)         (49)                                   
      Glioma Malignant                                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)                      
      Alveolar/Bronchiolar Adenoma                     2 (4%)                                 5 (10%)                               
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (10%)      2 (4%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Nose                                               (50)         (10)         (10)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)                                    (3)                                    
      Adenoma                                          3 (75%)                                3 (100%)                              
      Carcinoma                                        1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (10)         (50)                      (1)          
   Urinary Bladder                                    (50)         (10)         (10)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(10)        *(50)        *(10)        *(10)         
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(10)        *(10)        *(50)        *(10)        *(10)         
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         9 (18%)                                3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35                       2          33                       1               
     Total Primary Neoplasms                           54                       2          54                       1               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23                       1          25                       1               
     Total Benign Neoplasms                            29                       1          36                       1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21                       1          14                                       
     Total Malignant Neoplasms                         25                       1          18                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       1           2                                       
     Total Metastatic Neoplasm                          6                       1           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                               9           10                        10            9           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11                                     12                                     
    Natural Death                                      5                                      5                         1           
    Accidently Killed                                  1                                      1                                     
    Dosing Accident                                    1            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32                                     32                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (50)         (1)                       (43)         (10)         (10)         
   Intestine Small, Ileum                             (49)         (1)                       (50)         (10)         (9)          
   Intestine Small, Jejunum                           (50)         (1)                       (50)         (10)         (9)          
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hepatocellular Carcinoma                        10 (20%)                                7 (14%)                               
      Hepatocellular Carcinoma, Multiple, Two                                                 2 (4%)                                
      Hepatocellular Adenoma                          14 (28%)                                8 (16%)                   1 (10%)     
      Hepatocellular Adenoma, Multiple, Two            1 (2%)                                 1 (2%)                                
      Hepatocellular Adenoma, Multiple, Three                                                 1 (2%)                                
   Mesentery                                          (9)                                    (6)                                    
      Cholangiocarcinoma, Multiple, Metastatic,                                                                                     
           Greater Than Five, Liver                    1 (11%)                                                                      
      Hemangiosarcoma                                  1 (11%)                                                                      
   Pancreas                                           (50)         (1)                       (50)         (10)         (10)         
   Salivary Glands                                    (50)         (1)                       (49)         (9)          (10)         
   Stomach, Forestomach                               (50)         (1)                       (50)         (10)         (10)         
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                                 2 (4%)                                
   Stomach, Glandular                                 (50)         (1)                       (50)         (10)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)                       (50)         (10)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (1)                       (50)         (10)         (10)         
   Adrenal Gland, Medulla                             (50)         (1)                       (50)         (10)         (10)         
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (50)         (1)                       (50)         (10)         (10)         
      Adenoma                                          1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (48)         (1)                       (48)         (9)          (9)          
      Pars Distalis, Adenoma                           5 (10%)                                2 (4%)                                
   Thyroid Gland                                      (50)         (10)                      (50)         (10)         (10)         
      Follicular Cell, Adenoma                         1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                                                                           
   Ovary                                              (49)         (1)          (1)          (48)         (10)         (10)         
      Cystadenoma                                      1 (2%)                                                                       
      Hemangioma                                       1 (2%)                                 1 (2%)                                
      Mixed Tumor Benign                                                                      1 (2%)                                
      Teratoma Benign                                                            1 (100%)                                           
      Granulosa Cell, Adenoma                          1 (2%)                                                                       
   Uterus                                             (50)         (10)         (8)          (50)         (10)         (10)         
      Polyp Stromal                                                                           1 (2%)                                
      Sarcoma Stromal                                  1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (1)                       (50)         (10)         (10)         
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (50)         (1)                       (50)         (10)         (10)         
   Lymph Node, Mandibular                             (50)         (1)                       (47)         (9)          (10)         
   Lymph Node, Mesenteric                             (49)         (1)                       (45)         (10)         (10)         
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                 2 (4%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
                                                             Page   8                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (48)         (1)                       (48)         (8)          (10)         
      Schwannoma NOS                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (2)          (2)          (50)         (10)         (10)         
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 3 (6%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (1)                       (50)         (10)         (10)         
      Hemangiosarcoma                                  1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (1)                       (50)         (10)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Alveolar/Bronchiolar Adenoma                     4 (8%)                                 3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                                 1 (2%)                                
      Cholangiocarcinoma, Multiple, Metastatic,                                                                                     
           Greater Than Five, Liver                    1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                 3 (6%)                                
      Schwannoma NOS                                   1 (2%)                                                                       
      Mediastinum, Schwannoma NOS                      1 (2%)                                                                       
   Nose                                               (50)         (1)                       (50)         (10)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (10)                                   (7)                                    
      Adenoma                                          4 (40%)                                5 (71%)                               
      Carcinoma                                        2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (1)                       (50)         (10)         (10)         
   Urinary Bladder                                    (49)         (1)                       (50)         (10)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(10)        *(50)        *(10)        *(10)         
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Lymphoma Malignant Histiocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         4 (8%)                                 5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            34                       1          36                       1               
     Total Primary Neoplasms                           68                       1          52                       1               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23                       1          23                       1               
     Total Benign Neoplasms                            36                       1          28                       1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20                                  22                                       
     Total Malignant Neoplasms                         29                                  24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                   3                                       
     Total Metastatic Neoplasm                          4                                   3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          3                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                              10           10                        10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      4                                      4                                     
    Moribund Sacrifice                                13                                     14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                                     32                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (49)         (10)         (10)         (49)                                   
      Fibrous Histiocytoma                             1 (2%)                                                                       
   Intestine Small, Ileum                             (50)         (10)         (10)         (50)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Jejunum                           (50)         (10)         (10)         (49)                                   
      Adenocarcinoma                                                                          2 (4%)                                
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Cholangiocarcinoma, Multiple, Two                                                       1 (2%)                                
      Hemangiosarcoma                                                                         1 (2%)                                
      Hepatocellular Carcinoma                         8 (16%)                               10 (20%)                   1 (10%)     
      Hepatocellular Carcinoma, Multiple, Two          2 (4%)                                 2 (4%)                                
      Hepatocellular Adenoma                          11 (22%)                               12 (24%)                   1 (10%)     
      Hepatocellular Adenoma, Multiple, Two            8 (16%)                   1 (10%)      6 (12%)                   1 (10%)     
      Ito Cell Tumor Benign, Multiple, Two                                                    1 (2%)                                
   Mesentery                                          (2)                                    (4)                       (1)          
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (25%)                               
      Hemangioma                                                                              1 (25%)                               
      Hemangiosarcoma                                  1 (50%)                                                                      
   Pancreas                                           (50)         (10)         (10)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (10)         (10)         (50)                      (10)         
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          3 (6%)                    1 (10%)      2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (10)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (10)         (50)                                   
      Spindle Cell, Adenoma                                                                   1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (10)         (10)         (50)                                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (10)         (10)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (48)         (9)          (8)          (47)                                   
      Pars Distalis, Adenoma                                                                  1 (2%)                                
   Thyroid Gland                                      (50)         (10)         (10)         (50)         (10)         (1)          
      Follicular Cell, Adenoma                         1 (2%)                                 1 (2%)                                
      Follicular Cell, Carcinoma                                                                                        1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)         (10)         (50)                                   
   Prostate                                           (49)         (10)         (10)         (49)                                   
   Seminal Vesicle                                    (50)         (10)         (10)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
   Testes                                             (50)         (10)         (10)         (50)                                   
      Interstitial Cell, Adenoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)         (10)         (10)         
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (50)         (10)         (10)         (50)                                   
      Mediastinal, Cholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                                              1 (2%)                                
   Lymph Node, Mandibular                             (50)         (7)          (10)         (48)                                   
   Lymph Node, Mesenteric                             (49)         (8)          (10)         (47)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  4 (8%)                                                                       
                                                             Page  13                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (46)         (10)         (10)         (47)                                   
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (10)         (10)         (50)         (1)                       
      Subcutaneous Tissue, Fibrosarcoma                                                       2 (4%)                                
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                    (1)                                    
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (100%)                              
      Fibrosarcoma                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Alveolar/Bronchiolar Adenoma                     6 (12%)                                7 (14%)                               
      Alveolar/Bronchiolar Adenoma, Multiple, Two      1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   5 (10%)                                2 (4%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple, Two                                           1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             2 (4%)                                
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                    (1)                                    
      Fibrosarcoma                                     1 (50%)                                                                      
      Hemangiosarcoma                                  1 (50%)                                                                      
   Harderian Gland                                    (8)                                    (6)                                    
      Adenoma                                          4 (50%)                                5 (83%)                               
                                                             Page  14                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - cont                                                                                                        
      Carcinoma                                        1 (13%)                                2 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (10)         (50)                                   
   Urinary Bladder                                    (50)         (10)         (10)         (50)                      (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(10)        *(50)        *(10)        *(10)         
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Lymphocytic                                             1 (10%)                                            
      Lymphoma Malignant Mixed                         4 (8%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  15                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      VEHICLE      3 MG/KG      3 MG/KG      3 MG/KG         
                                                   CONTROL      9 SSAC       15 SSAC                   9 SSAC       15 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            33                       3          38                       3               
     Total Primary Neoplasms                           70                       3          67                       4               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27                       2          32                       2               
     Total Benign Neoplasms                            36                       2          41                       2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23                       1          22                       2               
     Total Malignant Neoplasms                         34                       1          26                       2               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                   3                                       
     Total Metastatic Neoplasm                          3                                   8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  16                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           10           10           50           10           10           
  Scheduled Sacrifice                                              10           10                        10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10                                     10                                     
    Natural Death                                      3                                      1                                     
    Drowned                                            1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36                                     39                                     
  Animals Examined Microscopically                    50           10           10           50           10           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)                                   (50)         (10)         (10)         
   Liver                                              (50)         (10)         (10)         (50)         (10)         (10)         
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hemangiosarcoma                                  2 (4%)                    1 (10%)      4 (8%)                                
      Hepatocellular Carcinoma                        11 (22%)                   1 (10%)      5 (10%)                   1 (10%)     
      Hepatocellular Carcinoma, Multiple, Two          1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma, Multiple, Three        1 (2%)                                                                       
      Hepatocellular Adenoma                          11 (22%)                   1 (10%)      8 (16%)                               
      Hepatocellular Adenoma, Multiple, Two            3 (6%)                                 1 (2%)                    1 (10%)     
      Hepatocellular Adenoma, Multiple, Three          1 (2%)                                                                       
      Hepatocellular Adenoma, Multiple, Four           1 (2%)                                                                       
   Mesentery                                          (6)                                    (1)                                    
      Cholangiocarcinoma, Metastatic, Liver            1 (17%)                                                                      
      Fibrosarcoma                                     1 (17%)                                                                      
   Pancreas                                           (50)                                   (49)         (10)         (10)         
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Mesentery              1 (2%)                                                                       
   Stomach, Forestomach                               (50)                      (10)         (50)         (10)         (10)         
      Squamous Cell Papilloma                          2 (4%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  17                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                                   (50)         (10)         (10)         
      Spindle Cell, Adenoma                            1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)                                   (50)         (10)         (10)         
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                 1 (2%)                                
   Islets, Pancreatic                                 (50)                                   (49)         (10)         (10)         
      Adenoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)                                   (50)         (10)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (10)         (50)         (10)         (10)         
      Hemangiosarcoma                                  1 (2%)                                 2 (4%)                                
   Lymph Node                                         (50)                      (1)          (49)         (10)         (10)         
   Lymph Node, Mandibular                             (49)                                   (48)         (10)         (9)          
   Lymph Node, Mesenteric                             (49)                      (1)          (45)         (10)         (10)         
   Spleen                                             (50)         (10)         (10)         (50)         (10)         (10)         
      Hemangioma                                       1 (2%)                                 1 (2%)                                
      Hemangiosarcoma                                  2 (4%)                                 2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (49)                                   (47)         (8)          (10)         
      Mediastinum, Hemangiosarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (2)                       (50)         (10)         (10)         
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  18                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                                    (1)                                    
      Fibrosarcoma, Metastatic, Mesentery              1 (50%)                                                                      
      Hemangiosarcoma                                                                         1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (10)         (50)         (10)         (10)         
      Alveolar/Bronchiolar Adenoma                     6 (12%)                                3 (6%)                    1 (10%)     
      Alveolar/Bronchiolar Adenoma, Multiple, Two      2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                 6 (12%)                               
      Carcinoma, Metastatic, Harderian Gland           2 (4%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                                 2 (4%)                                
   Nose                                               (50)                                   (50)         (10)         (10)         
      Polyp                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                                                           
      Fibrosarcoma                                     2 (100%)                                                                     
   Harderian Gland                                    (4)                                    (9)                                    
      Adenoma                                          3 (75%)                                7 (78%)                               
      Carcinoma                                        2 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)                      (50)         (10)         (10)         
   Urinary Bladder                                    (50)         (10)                      (50)         (10)         (10)         
      Hemangioma                                                                                           1 (10%)                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(10)        *(10)        *(50)        *(10)        *(10)         
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         3 (6%)                                                                       
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  19                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(10)        *(10)        *(50)        *(10)        *(10)         
____________________________________________________________________________________________________________________________________
                                                             Page  20                                                               
NTP Experiment-Test: 05093-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROANILINE                                      Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 21:13:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 MG/KG     30 MG/KG     30 MG/KG     100MG/KG     100MG/KG     100MG/KG        
                                                                 9 SSAC       15 SSAC                   9 SSAC       15 SSAC        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36                       3          28           1           2               
     Total Primary Neoplasms                           66                       3          46           1           3               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26                       1          19           1           2               
     Total Benign Neoplasms                            35                       1          24           1           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20                       2          15                       1               
     Total Malignant Neoplasms                         31                       2          22                       1               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5                                   2                                       
     Total Metastatic Neoplasm                          9                                   2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  21                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------