TDMS Study 05093-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst P-NITROANILINE DATE: 10/23/97
EXPERIMENT: 05093 TEST: 01 TIME: 07:02:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45038 ROUTE: GAVAGE NTP C#: 60786B
PATHOLOGIST: H. GILES S. EUSTIS CAS: 100-01-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 004 VEHICLE CONTROL
INCLUDE 007 100MG/KG
INCLUDE 010 100MG/KG
INCLUDE 013 30 MG/KG
INCLUDE 016 30 MG/KG
INCLUDE 019 3 MG/KG
INCLUDE 022 3 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst P-NITROANILINE DATE: 10/23/97
EXPERIMENT: 05093 TEST: 01 TIME: 07:02:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45038 ROUTE: GAVAGE NTP C#: 60786B
PATHOLOGIST: H. GILES S. EUSTIS CAS: 100-01-6
P-NITROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 8 518 527 540 575 611 619 640 667 692 |
| 721 721 724 725 725 725 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 399 525 536 555 570 571 584 602 611 654 |
| 654 659 681 681 701 701 714 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 445 478 501 570 591 599 631 680 690 701 |
| 701 725 725 |
| CENSORED DEATHS |
| 7 |
| |
==================================================================================
P-NITROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 298 477 563 571 649 656 701 716 724 725 |
| 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 98.0 98.0 98.0 98.0 98.0 92.0 90.0 84.0 66.0 |
|CONTROL | |
| | |
|3 MG/KG | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 84.0 76.0 64.0 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 100.0 100.0 95.9 93.9 87.8 85.7 73.5 |
| | |
| | |
|100MG/KG | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 92.0 88.0 78.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 64.0% 73.5% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.137N P=0.846 P=0.599N P=0.270N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 615.5 617.9 618.2 618.6 |
|NATURAL DEATHS (C) | (42.2) (19.8) (26.9) (40.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.4 689.0 685.8 704.7 |
|(STANDARD ERROR) | (16.0) (10.3) (16.9) (10.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 1 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 298 373 423 483 534 536 570 599 606 620 |
| 631 662 680 700 701 701 701 701 725 725 |
| CENSORED DEATHS |
| 2 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 341 478 553 581 606 653 667 700 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 2 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 424 448 465 484 560 654 655 667 672 692 |
| 703 716 716 720 723 725 |
| CENSORED DEATHS |
| 11 17 |
| |
==================================================================================
P-NITROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 1 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 402 477 501 542 634 651 665 667 681 692 |
| 708 711 716 723 724 725 725 |
| CENSORED DEATHS |
| 347 |
| |
==================================================================================
P-NITROANILINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 93.9 91.8 87.8 83.7 75.5 59.2 |
|CONTROL | |
| | |
|3 MG/KG | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 92.0 88.0 82.0 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 100.0 97.9 91.7 91.7 89.6 85.4 66.7 |
| | |
| | |
|100MG/KG | 100.0 100.0 100.0 100.0 98.0 95.9 91.8 91.8 85.7 65.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 3 MG/KG 30 MG/KG 100MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.2% 82.0% 66.7% 65.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.773 P=0.026N P=0.490N P=0.528N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.5 588.7 626.5 643.8 |
|NATURAL DEATHS (C) | (27.7) (39.9) (27.6) (24.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 662.2 703.7 667.6 692.4 |
|(STANDARD ERROR) | (19.6) (10.3) (22.0) (12.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROANILINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
3 MG/KG = 2
30 MG/KG = 3
100MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 2 3
|
| 1 4 2 3 3 1 2
| 3 3 1 212 4
95 +
| 3 121 243
| 1 2 21 4
| 3 3
P 90 + 1 33 1 44
E |
R | 2 2 3 11 3 4 4
C | 2 2 1 31 3 4 4
E 85 +
N | 2 2 1 1 33 44
T | 2 2 1 1
| 3 3
S 80 + 1 1
U |
R | 2 2 3 3 4
V | 2 2 11
I 75 +
V | 3 3
A | 2 2
L |
70 +
|
| 22
| 2 1 1
65 +
| 2 2
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
P-NITROANILINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
3 MG/KG = 2
30 MG/KG = 3
100MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 4 3
|
| 1 2 1 4 3 3 2
| 1 1 3 3 2 4 2
95 +
| 1 3 13 4 42 2
| 2 2
| 13 14 3 4
90 + 3 2 4 42
|
P | 1 1 42 42
E | 1 1 42 2
R 85 + 3 3
C | 11 4 4 2 2
E | 2 2
N | 1 1 3 43
T 80 + 1 1 4 4
| 3 3
S | 1 1 3 3
U |
R 75 + 1 1 44
V | 1 1 44
I |
V | 11 33
A 70 +
L |
|
| 3 3
65 + 4 4
| 1 1
|
|
60 +
| 1 1
|
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.