TDMS Study 05094-03 Pathology Tables
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
Facility: Southern Research Institute
Chemical CAS #: 85-68-7
Lock Date: 11/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 2.4%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 110 110
Scheduled Sacrifice 10 10
Early Deaths
Dead 4 1
Moribund 11 10
Moribund Sacrifice 34 38
Natural Death 6 1
Survivors
Terminal Sacrifice 10 11
Animals Examined Microscopically 110 110
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (109) (109)
Edema 1 (1%)
Parasite Metazoan 11 (10%) 4 (4%)
Intestine Large, Rectum (108) (110)
Parasite Metazoan 6 (6%) 9 (8%)
Intestine Large, Cecum (110) (110)
Edema 1 (1%) 1 (1%)
Parasite Metazoan 1 (1%)
Intestine Small, Duodenum (109) (110)
Erosion 1 (1%) 1 (1%)
Intestine Small, Jejunum (110) (110)
Fibrosis 1 (1%)
Perforation 1 (1%)
Muscularis, Hyperplasia 1 (1%)
Liver (110) (110)
Angiectasis 5 (5%) 1 (1%)
Basophilic Focus 82 (75%) 82 (75%)
Clear Cell Focus 6 (5%) 3 (3%)
Developmental Malformation 2 (2%)
Eosinophilic Focus 21 (19%) 34 (31%)
Granuloma 20 (18%) 13 (12%)
Hematopoietic Cell Proliferation 3 (3%) 1 (1%)
Hemorrhage 1 (1%)
Hepatodiaphragmatic Nodule 7 (6%) 14 (13%)
Inflammation, Subacute 5 (5%) 3 (3%)
Mixed Cell Focus 17 (15%) 1 (1%)
Thrombosis 2 (2%)
Bile Duct, Hyperplasia 17 (15%) 16 (15%)
Centrilobular, Necrosis 1 (1%)
Hepatocyte, Hyperplasia, Focal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 2.4%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Vacuolization Cytoplasmic 6 (5%) 1 (1%)
Kupffer Cell, Pigmentation 10 (9%) 26 (24%)
Lobules, Necrosis 10 (9%) 6 (5%)
Mesentery (6) (5)
Accessory Spleen 4 (67%) 1 (20%)
Hemorrhage 1 (20%)
Fat, Necrosis 2 (33%) 1 (20%)
Pancreas (107) (110)
Atrophy 53 (50%) 39 (35%)
Acinar Cell, Hyperplasia, Focal 1 (1%)
Acinus, Cytoplasmic Alteration 1 (1%)
Acinus, Metaplasia, Goblet Cell 1 (1%)
Salivary Glands (109) (110)
Duct, Cyst 1 (1%)
Stomach, Forestomach (107) (110)
Edema 2 (2%) 1 (1%)
Ulcer 1 (1%) 1 (1%)
Mucosa, Hyperplasia 5 (5%) 4 (4%)
Stomach, Glandular (108) (110)
Erosion 5 (5%) 3 (3%)
Mineralization 1 (1%)
Ulcer 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (109) (110)
Hypertrophy 1 (1%)
Thrombosis 1 (1%)
Heart (110) (110)
Cardiomyopathy 40 (36%) 39 (35%)
Thrombosis 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (110) (110)
Accessory Adrenal Cortical Nodule 23 (21%) 35 (32%)
Angiectasis 55 (50%) 70 (64%)
Degeneration, Fatty 27 (25%) 20 (18%)
Hematopoietic Cell Proliferation 1 (1%)
Hemorrhage 8 (7%)
Hyperplasia, Diffuse 1 (1%)
Hyperplasia, Focal 10 (9%) 8 (7%)
Hypertrophy, Focal 15 (14%) 5 (5%)
Necrosis 1 (1%)
Adrenal Medulla (108) (110)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 2.4%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 13 (12%) 10 (9%)
Islets, Pancreatic (107) (110)
Hyperplasia 2 (2%)
Metaplasia, Hepatocyte 2 (2%)
Parathyroid Gland (107) (103)
Angiectasis 1 (1%)
Cyst 1 (1%)
Pituitary Gland (110) (109)
Pars Distalis, Angiectasis 16 (15%) 11 (10%)
Pars Distalis, Cyst 27 (25%) 21 (19%)
Pars Distalis, Hyperplasia, Focal 23 (21%) 22 (20%)
Pars Intermedia, Angiectasis 3 (3%) 4 (4%)
Pars Intermedia, Cyst 7 (6%) 10 (9%)
Pars Intermedia, Hemorrhage 1 (1%)
Thyroid Gland (109) (110)
Ultimobranchial Cyst 1 (1%)
C-Cell, Hyperplasia 10 (9%) 11 (10%)
Follicle, Cyst 6 (6%) 2 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (110) (109)
Ectasia 26 (24%) 19 (17%)
Hyperplasia 5 (5%) 2 (2%)
Inflammation, Chronic 6 (5%) 5 (5%)
Inflammation, Suppurative 12 (11%) 5 (5%)
Ovary (110) (110)
Cyst 9 (8%) 12 (11%)
Uterus (110) (110)
Hydrometra 7 (6%) 10 (9%)
Hyperplasia, Cystic 15 (14%) 24 (22%)
Metaplasia, Squamous 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (110) (110)
Hypercellularity 2 (2%) 2 (2%)
Hyperplasia, Reticulum Cell 1 (1%)
Myelofibrosis 6 (5%) 7 (6%)
Necrosis 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 2.4%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node (32) (27)
Iliac, Ectasia 2 (6%)
Iliac, Hyperplasia, Lymphoid 2 (6%)
Inguinal, Hyperplasia, Lymphoid 1 (3%)
Mediastinal, Hemorrhage 3 (9%) 2 (7%)
Mediastinal, Hyperplasia, Lymphoid 1 (4%)
Mediastinal, Pigmentation 11 (34%) 3 (11%)
Pancreatic, Pigmentation 3 (9%) 7 (26%)
Renal, Hemorrhage 1 (3%) 1 (4%)
Renal, Pigmentation 2 (6%) 6 (22%)
Lymph Node, Mandibular (109) (110)
Ectasia 6 (6%) 9 (8%)
Hemorrhage 11 (10%) 17 (15%)
Hyperplasia, Lymphoid 1 (1%) 6 (5%)
Pigmentation 34 (31%) 29 (26%)
Lymph Node, Mesenteric (110) (110)
Hemorrhage 4 (4%) 5 (5%)
Hyperplasia, Lymphoid 2 (2%) 2 (2%)
Spleen (110) (110)
Fibrosis 9 (8%) 9 (8%)
Hematopoietic Cell Proliferation 29 (26%) 17 (15%)
Hemorrhage 2 (2%) 1 (1%)
Necrosis 1 (1%)
Pigmentation, Hemosiderin 48 (44%) 51 (46%)
Thymus (109) (106)
Atrophy 1 (1%)
Cyst 1 (1%)
Hemorrhage 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (109) (109)
Ectasia 38 (35%) 17 (16%)
Galactocele 3 (3%)
Hyperplasia 40 (37%) 50 (46%)
Skin (110) (109)
Acanthosis 5 (5%) 11 (10%)
Cyst Epithelial Inclusion 1 (1%)
Edema 2 (2%)
Hyperkeratosis 3 (3%) 2 (2%)
Inflammation, Chronic 1 (1%) 1 (1%)
Ulcer 3 (3%) 8 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 2.4%
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (110) (110)
Cranium, Osteopetrosis 18 (16%) 11 (10%)
Femur, Osteopetrosis 14 (13%) 13 (12%)
Rib, Osteopetrosis 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (110) (109)
Compression 19 (17%) 12 (11%)
Hemorrhage 1 (1%) 3 (3%)
Hydrocephalus 4 (4%) 4 (4%)
Inflammation, Chronic 1 (1%)
Necrosis 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (110) (110)
Congestion 3 (3%)
Edema 1 (1%) 1 (1%)
Hemorrhage 3 (3%) 1 (1%)
Infiltration Cellular, Histiocyte 34 (31%) 44 (40%)
Inflammation, Subacute 2 (2%) 1 (1%)
Alveolar Epithelium, Hyperplasia 9 (8%) 2 (2%)
Nose (110) (110)
Exudate 6 (5%) 9 (8%)
Foreign Body 2 (2%) 1 (1%)
Fungus 2 (2%) 2 (2%)
Mucosa, Hyperplasia 5 (5%) 6 (5%)
Mucosa, Metaplasia, Squamous 3 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (4)
Atrophy 1 (20%)
Cataract 3 (60%) 4 (100%)
Retina, Degeneration 3 (60%) 4 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 2.4%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (110) (110)
Calculus Micro Observation Only 1 (1%) 17 (15%)
Cyst 2 (2%)
Hydronephrosis 1 (1%)
Inflammation, Suppurative 2 (2%)
Mineralization 101 (92%) 73 (66%)
Nephropathy 90 (82%) 105 (95%)
Papilla, Necrosis 3 (3%)
Renal Tubule, Atrophy 9 (8%)
Renal Tubule, Dilatation 18 (16%)
Renal Tubule, Hyperplasia 1 (1%) 1 (1%)
Renal Tubule, Necrosis 1 (1%)
Renal Tubule, Pigmentation 106 (96%) 108 (98%)
Transitional Epithelium, Hyperplasia 3 (3%) 49 (45%)
Urinary Bladder (109) (110)
Calculus Micro Observation Only 1 (1%)
Transitional Epithelium, Hyperplasia 30 (27%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.2%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 110 110
Scheduled Sacrifice 10 10
Early Deaths
Moribund 14 17
Accidently Killed 1
Dead 1 2
Moribund Sacrifice 37 29
Natural Death 3 8
Survivors
Terminal Sacrifice 10 13
Animals Examined Microscopically 110 110
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (108) (106)
Edema 1 (1%)
Parasite Metazoan 9 (8%) 9 (8%)
Intestine Large, Rectum (110) (108)
Parasite Metazoan 11 (10%) 11 (10%)
Intestine Large, Cecum (108) (109)
Edema 4 (4%) 9 (8%)
Parasite Metazoan 1 (1%)
Ulcer 1 (1%) 1 (1%)
Liver (110) (109)
Angiectasis 3 (3%) 4 (4%)
Basophilic Focus 24 (22%) 27 (25%)
Clear Cell Focus 2 (2%) 10 (9%)
Congestion 2 (2%)
Cyst 1 (1%)
Degeneration, Cystic 5 (5%) 2 (2%)
Developmental Malformation 4 (4%)
Eosinophilic Focus 9 (8%) 13 (12%)
Granuloma 2 (2%) 4 (4%)
Hematopoietic Cell Proliferation 4 (4%)
Hepatodiaphragmatic Nodule 5 (5%) 9 (8%)
Inflammation, Subacute 2 (2%) 2 (2%)
Mixed Cell Focus 1 (1%) 2 (2%)
Thrombosis 2 (2%) 1 (1%)
Bile Duct, Hyperplasia 68 (62%) 45 (41%)
Centrilobular, Necrosis 1 (1%)
Hepatocyte, Hyperplasia, Focal 1 (1%) 1 (1%)
Hepatocyte, Vacuolization Cytoplasmic 8 (7%) 4 (4%)
Kupffer Cell, Hyperplasia 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.2%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Kupffer Cell, Pigmentation 8 (7%) 11 (10%)
Lobules, Necrosis 6 (5%) 8 (7%)
Mesentery (22) (19)
Accessory Spleen 3 (14%) 4 (21%)
Fat, Necrosis 17 (77%) 12 (63%)
Pancreas (110) (109)
Atrophy 70 (64%) 63 (58%)
Edema 1 (1%)
Inflammation, Chronic 1 (1%)
Acinus, Cytoplasmic Alteration 3 (3%) 3 (3%)
Acinus, Hyperplasia, Focal 5 (5%)
Salivary Glands (110) (109)
Atrophy 1 (1%)
Stomach, Forestomach (110) (110)
Edema 2 (2%) 1 (1%)
Hyperplasia, Squamous 1 (1%)
Mineralization 1 (1%)
Ulcer 2 (2%) 2 (2%)
Mucosa, Hyperplasia 4 (4%) 3 (3%)
Stomach, Glandular (110) (109)
Edema 2 (2%) 1 (1%)
Erosion 6 (5%) 8 (7%)
Mineralization 1 (1%)
Ulcer 4 (4%) 1 (1%)
Tongue (2) (1)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (110) (110)
Cardiomyopathy 60 (55%) 65 (59%)
Inflammation, Chronic 2 (2%)
Thrombosis 7 (6%) 5 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (110) (110)
Accessory Adrenal Cortical Nodule 35 (32%) 36 (33%)
Angiectasis 48 (44%) 51 (46%)
Cyst 2 (2%)
Degeneration, Fatty 18 (16%) 7 (6%)
Hematopoietic Cell Proliferation 1 (1%) 1 (1%)
Hemorrhage 2 (2%)
Hyperplasia, Focal 18 (16%) 5 (5%)
Hypertrophy, Focal 7 (6%) 5 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.2%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Metaplasia, Osseous 1 (1%)
Necrosis 1 (1%)
Thrombosis 4 (4%) 1 (1%)
Adrenal Medulla (110) (110)
Hyperplasia 23 (21%) 12 (11%)
Necrosis 1 (1%)
Islets, Pancreatic (110) (109)
Hyperplasia 1 (1%) 2 (2%)
Pituitary Gland (106) (105)
Pars Distalis, Angiectasis 4 (4%) 2 (2%)
Pars Distalis, Cyst 18 (17%) 14 (13%)
Pars Distalis, Hyperplasia, Focal 24 (23%) 16 (15%)
Pars Intermedia, Angiectasis 3 (3%)
Pars Intermedia, Cyst 7 (7%) 4 (4%)
Thyroid Gland (110) (110)
C-Cell, Hyperplasia 14 (13%) 9 (8%)
Follicle, Cyst 4 (4%) 2 (2%)
Follicular Cell, Hyperplasia 2 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (110) (110)
Atypia Cellular 70 (64%) 59 (54%)
Hypospermia 77 (70%) 84 (76%)
Preputial Gland (110) (110)
Ectasia 30 (27%) 25 (23%)
Hyperplasia 1 (1%) 1 (1%)
Inflammation, Chronic 52 (47%) 38 (35%)
Inflammation, Suppurative 21 (19%) 15 (14%)
Prostate (109) (110)
Corpora Amylacea 46 (42%) 59 (54%)
Edema 1 (1%)
Inflammation, Suppurative 52 (48%) 40 (36%)
Epithelium, Hyperplasia 17 (16%) 13 (12%)
Seminal Vesicle (110) (108)
Dilatation 1 (1%)
Testes (110) (110)
Interstitial Cell, Hyperplasia 22 (20%) 17 (15%)
Seminiferous Tubule, Atrophy 10 (9%) 9 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.2%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (110) (110)
Hypercellularity 3 (3%) 4 (4%)
Hyperplasia, Reticulum Cell 1 (1%)
Myelofibrosis 9 (8%) 7 (6%)
Lymph Node (42) (42)
Deep Cervical, Hemorrhage 1 (2%)
Iliac, Hemorrhage 1 (2%)
Inguinal, Pigmentation 1 (2%)
Mediastinal, Hemorrhage 3 (7%) 4 (10%)
Mediastinal, Pigmentation 19 (45%) 10 (24%)
Pancreatic, Ectasia 1 (2%)
Pancreatic, Hemorrhage 1 (2%) 1 (2%)
Pancreatic, Necrosis 1 (2%)
Pancreatic, Pigmentation 11 (26%) 9 (21%)
Renal, Pigmentation 6 (14%) 3 (7%)
Lymph Node, Mandibular (107) (106)
Ectasia 10 (9%) 4 (4%)
Hemorrhage 12 (11%) 13 (12%)
Hyperplasia, Lymphoid 7 (7%) 4 (4%)
Pigmentation 21 (20%) 15 (14%)
Lymph Node, Mesenteric (110) (109)
Ectasia 2 (2%) 1 (1%)
Hemorrhage 2 (2%) 3 (3%)
Hyperplasia, Lymphoid 5 (5%) 1 (1%)
Pigmentation 1 (1%)
Spleen (110) (109)
Developmental Malformation 1 (1%)
Fibrosis 16 (15%) 23 (21%)
Hematopoietic Cell Proliferation 13 (12%) 8 (7%)
Infiltration Cellular, Histiocyte 1 (1%)
Inflammation, Chronic 1 (1%)
Metaplasia, Lipocyte 1 (1%)
Necrosis 1 (1%) 2 (2%)
Pigmentation, Hemosiderin 14 (13%) 8 (7%)
Lymphoid Follicle, Hyperplasia 1 (1%)
Thymus (102) (103)
Ectopic Parathyroid Gland 1 (1%)
Hemorrhage 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (104) (108)
Hyperplasia 17 (16%) 18 (17%)
Skin (109) (108)
Acanthosis 4 (4%) 7 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.2%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Cyst Epithelial Inclusion 2 (2%) 2 (2%)
Hemorrhage 1 (1%) 1 (1%)
Hyperkeratosis 5 (5%) 7 (6%)
Inflammation, Chronic 1 (1%) 3 (3%)
Inflammation, Chronic Active 1 (1%)
Ulcer 3 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (110) (110)
Cranium, Osteopetrosis 3 (3%) 2 (2%)
Femur, Osteopetrosis 2 (2%) 3 (3%)
Rib, Osteopetrosis 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (110) (109)
Compression 3 (3%) 5 (5%)
Hydrocephalus 4 (4%) 2 (2%)
Necrosis 3 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (110) (110)
Congestion 1 (1%)
Edema 2 (2%) 1 (1%)
Hemorrhage 1 (1%) 1 (1%)
Infiltration Cellular, Histiocyte 13 (12%) 24 (22%)
Inflammation, Subacute 1 (1%) 2 (2%)
Inflammation, Suppurative 1 (1%)
Alveolar Epithelium, Hyperplasia 11 (10%) 6 (5%)
Nose (110) (110)
Exudate 21 (19%) 14 (13%)
Foreign Body 8 (7%) 3 (3%)
Fungus 15 (14%) 9 (8%)
Mucosa, Hyperplasia 14 (13%) 8 (7%)
Mucosa, Metaplasia, Squamous 15 (14%) 6 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05094-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 14:12:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.2%
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Hemorrhage 1 (100%)
Inflammation, Chronic 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (110) (109)
Calculus Micro Observation Only 2 (2%) 1 (1%)
Congestion 1 (1%)
Cyst 2 (2%) 3 (3%)
Hydronephrosis 1 (1%)
Mineralization 11 (10%) 10 (9%)
Nephropathy 100 (91%) 104 (95%)
Thrombosis 1 (1%) 2 (2%)
Renal Tubule, Atrophy 1 (1%) 3 (3%)
Renal Tubule, Dilatation 4 (4%) 8 (7%)
Renal Tubule, Hyperplasia 1 (1%)
Renal Tubule, Necrosis 5 (5%) 5 (5%)
Renal Tubule, Pigmentation 105 (95%) 104 (95%)
Transitional Epithelium, Hyperplasia 3 (3%) 3 (3%)
Urinary Bladder (110) (110)
Hemorrhage 3 (3%)
Transitional Epithelium, Hyperplasia 1 (1%) 3 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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