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TDMS Study 05094-03 Pathology Tables

NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96
Route: DOSED FEED                                                                                                 Time: 14:12:18




       Facility:  Southern Research Institute

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                         110          110                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Dead                                               4            1                                                               
    Moribund                                          11           10                                                               
    Moribund Sacrifice                                34           38                                                               
    Natural Death                                      6            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           11                                                               

  Animals Examined Microscopically                   110          110                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (109)        (109)                                                            
      Edema                                            1 (1%)                                                                       
      Parasite Metazoan                               11 (10%)      4 (4%)                                                          
   Intestine Large, Rectum                            (108)        (110)                                                            
      Parasite Metazoan                                6 (6%)       9 (8%)                                                          
   Intestine Large, Cecum                             (110)        (110)                                                            
      Edema                                            1 (1%)       1 (1%)                                                          
      Parasite Metazoan                                             1 (1%)                                                          
   Intestine Small, Duodenum                          (109)        (110)                                                            
      Erosion                                          1 (1%)       1 (1%)                                                          
   Intestine Small, Jejunum                           (110)        (110)                                                            
      Fibrosis                                                      1 (1%)                                                          
      Perforation                                                   1 (1%)                                                          
      Muscularis, Hyperplasia                                       1 (1%)                                                          
   Liver                                              (110)        (110)                                                            
      Angiectasis                                      5 (5%)       1 (1%)                                                          
      Basophilic Focus                                82 (75%)     82 (75%)                                                         
      Clear Cell Focus                                 6 (5%)       3 (3%)                                                          
      Developmental Malformation                       2 (2%)                                                                       
      Eosinophilic Focus                              21 (19%)     34 (31%)                                                         
      Granuloma                                       20 (18%)     13 (12%)                                                         
      Hematopoietic Cell Proliferation                 3 (3%)       1 (1%)                                                          
      Hemorrhage                                       1 (1%)                                                                       
      Hepatodiaphragmatic Nodule                       7 (6%)      14 (13%)                                                         
      Inflammation, Subacute                           5 (5%)       3 (3%)                                                          
      Mixed Cell Focus                                17 (15%)      1 (1%)                                                          
      Thrombosis                                                    2 (2%)                                                          
      Bile Duct, Hyperplasia                          17 (15%)     16 (15%)                                                         
      Centrilobular, Necrosis                          1 (1%)                                                                       
      Hepatocyte, Hyperplasia, Focal                                1 (1%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Vacuolization Cytoplasmic            6 (5%)       1 (1%)                                                          
      Kupffer Cell, Pigmentation                      10 (9%)      26 (24%)                                                         
      Lobules, Necrosis                               10 (9%)       6 (5%)                                                          
   Mesentery                                          (6)          (5)                                                              
      Accessory Spleen                                 4 (67%)      1 (20%)                                                         
      Hemorrhage                                                    1 (20%)                                                         
      Fat, Necrosis                                    2 (33%)      1 (20%)                                                         
   Pancreas                                           (107)        (110)                                                            
      Atrophy                                         53 (50%)     39 (35%)                                                         
      Acinar Cell, Hyperplasia, Focal                               1 (1%)                                                          
      Acinus, Cytoplasmic Alteration                                1 (1%)                                                          
      Acinus, Metaplasia, Goblet Cell                               1 (1%)                                                          
   Salivary Glands                                    (109)        (110)                                                            
      Duct, Cyst                                                    1 (1%)                                                          
   Stomach, Forestomach                               (107)        (110)                                                            
      Edema                                            2 (2%)       1 (1%)                                                          
      Ulcer                                            1 (1%)       1 (1%)                                                          
      Mucosa, Hyperplasia                              5 (5%)       4 (4%)                                                          
   Stomach, Glandular                                 (108)        (110)                                                            
      Erosion                                          5 (5%)       3 (3%)                                                          
      Mineralization                                   1 (1%)                                                                       
      Ulcer                                                         1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (109)        (110)                                                            
      Hypertrophy                                                   1 (1%)                                                          
      Thrombosis                                                    1 (1%)                                                          
   Heart                                              (110)        (110)                                                            
      Cardiomyopathy                                  40 (36%)     39 (35%)                                                         
      Thrombosis                                       1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (110)        (110)                                                            
      Accessory Adrenal Cortical Nodule               23 (21%)     35 (32%)                                                         
      Angiectasis                                     55 (50%)     70 (64%)                                                         
      Degeneration, Fatty                             27 (25%)     20 (18%)                                                         
      Hematopoietic Cell Proliferation                              1 (1%)                                                          
      Hemorrhage                                                    8 (7%)                                                          
      Hyperplasia, Diffuse                                          1 (1%)                                                          
      Hyperplasia, Focal                              10 (9%)       8 (7%)                                                          
      Hypertrophy, Focal                              15 (14%)      5 (5%)                                                          
      Necrosis                                         1 (1%)                                                                       
   Adrenal Medulla                                    (108)        (110)                                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                     13 (12%)     10 (9%)                                                          
   Islets, Pancreatic                                 (107)        (110)                                                            
      Hyperplasia                                                   2 (2%)                                                          
      Metaplasia, Hepatocyte                                        2 (2%)                                                          
   Parathyroid Gland                                  (107)        (103)                                                            
      Angiectasis                                                   1 (1%)                                                          
      Cyst                                                          1 (1%)                                                          
   Pituitary Gland                                    (110)        (109)                                                            
      Pars Distalis, Angiectasis                      16 (15%)     11 (10%)                                                         
      Pars Distalis, Cyst                             27 (25%)     21 (19%)                                                         
      Pars Distalis, Hyperplasia, Focal               23 (21%)     22 (20%)                                                         
      Pars Intermedia, Angiectasis                     3 (3%)       4 (4%)                                                          
      Pars Intermedia, Cyst                            7 (6%)      10 (9%)                                                          
      Pars Intermedia, Hemorrhage                      1 (1%)                                                                       
   Thyroid Gland                                      (109)        (110)                                                            
      Ultimobranchial Cyst                             1 (1%)                                                                       
      C-Cell, Hyperplasia                             10 (9%)      11 (10%)                                                         
      Follicle, Cyst                                   6 (6%)       2 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (110)        (109)                                                            
      Ectasia                                         26 (24%)     19 (17%)                                                         
      Hyperplasia                                      5 (5%)       2 (2%)                                                          
      Inflammation, Chronic                            6 (5%)       5 (5%)                                                          
      Inflammation, Suppurative                       12 (11%)      5 (5%)                                                          
   Ovary                                              (110)        (110)                                                            
      Cyst                                             9 (8%)      12 (11%)                                                         
   Uterus                                             (110)        (110)                                                            
      Hydrometra                                       7 (6%)      10 (9%)                                                          
      Hyperplasia, Cystic                             15 (14%)     24 (22%)                                                         
      Metaplasia, Squamous                             1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (110)        (110)                                                            
      Hypercellularity                                 2 (2%)       2 (2%)                                                          
      Hyperplasia, Reticulum Cell                                   1 (1%)                                                          
      Myelofibrosis                                    6 (5%)       7 (6%)                                                          
      Necrosis                                                      1 (1%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node                                         (32)         (27)                                                             
      Iliac, Ectasia                                   2 (6%)                                                                       
      Iliac, Hyperplasia, Lymphoid                     2 (6%)                                                                       
      Inguinal, Hyperplasia, Lymphoid                  1 (3%)                                                                       
      Mediastinal, Hemorrhage                          3 (9%)       2 (7%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                            1 (4%)                                                          
      Mediastinal, Pigmentation                       11 (34%)      3 (11%)                                                         
      Pancreatic, Pigmentation                         3 (9%)       7 (26%)                                                         
      Renal, Hemorrhage                                1 (3%)       1 (4%)                                                          
      Renal, Pigmentation                              2 (6%)       6 (22%)                                                         
   Lymph Node, Mandibular                             (109)        (110)                                                            
      Ectasia                                          6 (6%)       9 (8%)                                                          
      Hemorrhage                                      11 (10%)     17 (15%)                                                         
      Hyperplasia, Lymphoid                            1 (1%)       6 (5%)                                                          
      Pigmentation                                    34 (31%)     29 (26%)                                                         
   Lymph Node, Mesenteric                             (110)        (110)                                                            
      Hemorrhage                                       4 (4%)       5 (5%)                                                          
      Hyperplasia, Lymphoid                            2 (2%)       2 (2%)                                                          
   Spleen                                             (110)        (110)                                                            
      Fibrosis                                         9 (8%)       9 (8%)                                                          
      Hematopoietic Cell Proliferation                29 (26%)     17 (15%)                                                         
      Hemorrhage                                       2 (2%)       1 (1%)                                                          
      Necrosis                                                      1 (1%)                                                          
      Pigmentation, Hemosiderin                       48 (44%)     51 (46%)                                                         
   Thymus                                             (109)        (106)                                                            
      Atrophy                                                       1 (1%)                                                          
      Cyst                                             1 (1%)                                                                       
      Hemorrhage                                       1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (109)        (109)                                                            
      Ectasia                                         38 (35%)     17 (16%)                                                         
      Galactocele                                      3 (3%)                                                                       
      Hyperplasia                                     40 (37%)     50 (46%)                                                         
   Skin                                               (110)        (109)                                                            
      Acanthosis                                       5 (5%)      11 (10%)                                                         
      Cyst Epithelial Inclusion                                     1 (1%)                                                          
      Edema                                                         2 (2%)                                                          
      Hyperkeratosis                                   3 (3%)       2 (2%)                                                          
      Inflammation, Chronic                            1 (1%)       1 (1%)                                                          
      Ulcer                                            3 (3%)       8 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (110)        (110)                                                            
      Cranium, Osteopetrosis                          18 (16%)     11 (10%)                                                         
      Femur, Osteopetrosis                            14 (13%)     13 (12%)                                                         
      Rib, Osteopetrosis                               1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (110)        (109)                                                            
      Compression                                     19 (17%)     12 (11%)                                                         
      Hemorrhage                                       1 (1%)       3 (3%)                                                          
      Hydrocephalus                                    4 (4%)       4 (4%)                                                          
      Inflammation, Chronic                                         1 (1%)                                                          
      Necrosis                                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (110)        (110)                                                            
      Congestion                                       3 (3%)                                                                       
      Edema                                            1 (1%)       1 (1%)                                                          
      Hemorrhage                                       3 (3%)       1 (1%)                                                          
      Infiltration Cellular, Histiocyte               34 (31%)     44 (40%)                                                         
      Inflammation, Subacute                           2 (2%)       1 (1%)                                                          
      Alveolar Epithelium, Hyperplasia                 9 (8%)       2 (2%)                                                          
   Nose                                               (110)        (110)                                                            
      Exudate                                          6 (5%)       9 (8%)                                                          
      Foreign Body                                     2 (2%)       1 (1%)                                                          
      Fungus                                           2 (2%)       2 (2%)                                                          
      Mucosa, Hyperplasia                              5 (5%)       6 (5%)                                                          
      Mucosa, Metaplasia, Squamous                     3 (3%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (4)                                                              
      Atrophy                                          1 (20%)                                                                      
      Cataract                                         3 (60%)      4 (100%)                                                        
      Retina, Degeneration                             3 (60%)      4 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (110)        (110)                                                            
      Calculus Micro Observation Only                  1 (1%)      17 (15%)                                                         
      Cyst                                                          2 (2%)                                                          
      Hydronephrosis                                                1 (1%)                                                          
      Inflammation, Suppurative                                     2 (2%)                                                          
      Mineralization                                 101 (92%)     73 (66%)                                                         
      Nephropathy                                     90 (82%)    105 (95%)                                                         
      Papilla, Necrosis                                             3 (3%)                                                          
      Renal Tubule, Atrophy                                         9 (8%)                                                          
      Renal Tubule, Dilatation                                     18 (16%)                                                         
      Renal Tubule, Hyperplasia                        1 (1%)       1 (1%)                                                          
      Renal Tubule, Necrosis                                        1 (1%)                                                          
      Renal Tubule, Pigmentation                     106 (96%)    108 (98%)                                                         
      Transitional Epithelium, Hyperplasia             3 (3%)      49 (45%)                                                         
   Urinary Bladder                                    (109)        (110)                                                            
      Calculus Micro Observation Only                               1 (1%)                                                          
      Transitional Epithelium, Hyperplasia                         30 (27%)                                                         
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                         110          110                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Moribund                                          14           17                                                               
    Accidently Killed                                  1                                                                            
    Dead                                               1            2                                                               
    Moribund Sacrifice                                37           29                                                               
    Natural Death                                      3            8                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           13                                                               

  Animals Examined Microscopically                   110          110                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (108)        (106)                                                            
      Edema                                            1 (1%)                                                                       
      Parasite Metazoan                                9 (8%)       9 (8%)                                                          
   Intestine Large, Rectum                            (110)        (108)                                                            
      Parasite Metazoan                               11 (10%)     11 (10%)                                                         
   Intestine Large, Cecum                             (108)        (109)                                                            
      Edema                                            4 (4%)       9 (8%)                                                          
      Parasite Metazoan                                1 (1%)                                                                       
      Ulcer                                            1 (1%)       1 (1%)                                                          
   Liver                                              (110)        (109)                                                            
      Angiectasis                                      3 (3%)       4 (4%)                                                          
      Basophilic Focus                                24 (22%)     27 (25%)                                                         
      Clear Cell Focus                                 2 (2%)      10 (9%)                                                          
      Congestion                                                    2 (2%)                                                          
      Cyst                                                          1 (1%)                                                          
      Degeneration, Cystic                             5 (5%)       2 (2%)                                                          
      Developmental Malformation                       4 (4%)                                                                       
      Eosinophilic Focus                               9 (8%)      13 (12%)                                                         
      Granuloma                                        2 (2%)       4 (4%)                                                          
      Hematopoietic Cell Proliferation                 4 (4%)                                                                       
      Hepatodiaphragmatic Nodule                       5 (5%)       9 (8%)                                                          
      Inflammation, Subacute                           2 (2%)       2 (2%)                                                          
      Mixed Cell Focus                                 1 (1%)       2 (2%)                                                          
      Thrombosis                                       2 (2%)       1 (1%)                                                          
      Bile Duct, Hyperplasia                          68 (62%)     45 (41%)                                                         
      Centrilobular, Necrosis                                       1 (1%)                                                          
      Hepatocyte, Hyperplasia, Focal                   1 (1%)       1 (1%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic            8 (7%)       4 (4%)                                                          
      Kupffer Cell, Hyperplasia                        1 (1%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Pigmentation                       8 (7%)      11 (10%)                                                         
      Lobules, Necrosis                                6 (5%)       8 (7%)                                                          
   Mesentery                                          (22)         (19)                                                             
      Accessory Spleen                                 3 (14%)      4 (21%)                                                         
      Fat, Necrosis                                   17 (77%)     12 (63%)                                                         
   Pancreas                                           (110)        (109)                                                            
      Atrophy                                         70 (64%)     63 (58%)                                                         
      Edema                                            1 (1%)                                                                       
      Inflammation, Chronic                                         1 (1%)                                                          
      Acinus, Cytoplasmic Alteration                   3 (3%)       3 (3%)                                                          
      Acinus, Hyperplasia, Focal                                    5 (5%)                                                          
   Salivary Glands                                    (110)        (109)                                                            
      Atrophy                                                       1 (1%)                                                          
   Stomach, Forestomach                               (110)        (110)                                                            
      Edema                                            2 (2%)       1 (1%)                                                          
      Hyperplasia, Squamous                                         1 (1%)                                                          
      Mineralization                                                1 (1%)                                                          
      Ulcer                                            2 (2%)       2 (2%)                                                          
      Mucosa, Hyperplasia                              4 (4%)       3 (3%)                                                          
   Stomach, Glandular                                 (110)        (109)                                                            
      Edema                                            2 (2%)       1 (1%)                                                          
      Erosion                                          6 (5%)       8 (7%)                                                          
      Mineralization                                                1 (1%)                                                          
      Ulcer                                            4 (4%)       1 (1%)                                                          
   Tongue                                             (2)          (1)                                                              
      Inflammation, Suppurative                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (110)        (110)                                                            
      Cardiomyopathy                                  60 (55%)     65 (59%)                                                         
      Inflammation, Chronic                            2 (2%)                                                                       
      Thrombosis                                       7 (6%)       5 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (110)        (110)                                                            
      Accessory Adrenal Cortical Nodule               35 (32%)     36 (33%)                                                         
      Angiectasis                                     48 (44%)     51 (46%)                                                         
      Cyst                                                          2 (2%)                                                          
      Degeneration, Fatty                             18 (16%)      7 (6%)                                                          
      Hematopoietic Cell Proliferation                 1 (1%)       1 (1%)                                                          
      Hemorrhage                                       2 (2%)                                                                       
      Hyperplasia, Focal                              18 (16%)      5 (5%)                                                          
      Hypertrophy, Focal                               7 (6%)       5 (5%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Metaplasia, Osseous                                           1 (1%)                                                          
      Necrosis                                                      1 (1%)                                                          
      Thrombosis                                       4 (4%)       1 (1%)                                                          
   Adrenal Medulla                                    (110)        (110)                                                            
      Hyperplasia                                     23 (21%)     12 (11%)                                                         
      Necrosis                                         1 (1%)                                                                       
   Islets, Pancreatic                                 (110)        (109)                                                            
      Hyperplasia                                      1 (1%)       2 (2%)                                                          
   Pituitary Gland                                    (106)        (105)                                                            
      Pars Distalis, Angiectasis                       4 (4%)       2 (2%)                                                          
      Pars Distalis, Cyst                             18 (17%)     14 (13%)                                                         
      Pars Distalis, Hyperplasia, Focal               24 (23%)     16 (15%)                                                         
      Pars Intermedia, Angiectasis                                  3 (3%)                                                          
      Pars Intermedia, Cyst                            7 (7%)       4 (4%)                                                          
   Thyroid Gland                                      (110)        (110)                                                            
      C-Cell, Hyperplasia                             14 (13%)      9 (8%)                                                          
      Follicle, Cyst                                   4 (4%)       2 (2%)                                                          
      Follicular Cell, Hyperplasia                                  2 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (110)        (110)                                                            
      Atypia Cellular                                 70 (64%)     59 (54%)                                                         
      Hypospermia                                     77 (70%)     84 (76%)                                                         
   Preputial Gland                                    (110)        (110)                                                            
      Ectasia                                         30 (27%)     25 (23%)                                                         
      Hyperplasia                                      1 (1%)       1 (1%)                                                          
      Inflammation, Chronic                           52 (47%)     38 (35%)                                                         
      Inflammation, Suppurative                       21 (19%)     15 (14%)                                                         
   Prostate                                           (109)        (110)                                                            
      Corpora Amylacea                                46 (42%)     59 (54%)                                                         
      Edema                                                         1 (1%)                                                          
      Inflammation, Suppurative                       52 (48%)     40 (36%)                                                         
      Epithelium, Hyperplasia                         17 (16%)     13 (12%)                                                         
   Seminal Vesicle                                    (110)        (108)                                                            
      Dilatation                                       1 (1%)                                                                       
   Testes                                             (110)        (110)                                                            
      Interstitial Cell, Hyperplasia                  22 (20%)     17 (15%)                                                         
      Seminiferous Tubule, Atrophy                    10 (9%)       9 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (110)        (110)                                                            
      Hypercellularity                                 3 (3%)       4 (4%)                                                          
      Hyperplasia, Reticulum Cell                      1 (1%)                                                                       
      Myelofibrosis                                    9 (8%)       7 (6%)                                                          
   Lymph Node                                         (42)         (42)                                                             
      Deep Cervical, Hemorrhage                        1 (2%)                                                                       
      Iliac, Hemorrhage                                             1 (2%)                                                          
      Inguinal, Pigmentation                           1 (2%)                                                                       
      Mediastinal, Hemorrhage                          3 (7%)       4 (10%)                                                         
      Mediastinal, Pigmentation                       19 (45%)     10 (24%)                                                         
      Pancreatic, Ectasia                                           1 (2%)                                                          
      Pancreatic, Hemorrhage                           1 (2%)       1 (2%)                                                          
      Pancreatic, Necrosis                                          1 (2%)                                                          
      Pancreatic, Pigmentation                        11 (26%)      9 (21%)                                                         
      Renal, Pigmentation                              6 (14%)      3 (7%)                                                          
   Lymph Node, Mandibular                             (107)        (106)                                                            
      Ectasia                                         10 (9%)       4 (4%)                                                          
      Hemorrhage                                      12 (11%)     13 (12%)                                                         
      Hyperplasia, Lymphoid                            7 (7%)       4 (4%)                                                          
      Pigmentation                                    21 (20%)     15 (14%)                                                         
   Lymph Node, Mesenteric                             (110)        (109)                                                            
      Ectasia                                          2 (2%)       1 (1%)                                                          
      Hemorrhage                                       2 (2%)       3 (3%)                                                          
      Hyperplasia, Lymphoid                            5 (5%)       1 (1%)                                                          
      Pigmentation                                                  1 (1%)                                                          
   Spleen                                             (110)        (109)                                                            
      Developmental Malformation                       1 (1%)                                                                       
      Fibrosis                                        16 (15%)     23 (21%)                                                         
      Hematopoietic Cell Proliferation                13 (12%)      8 (7%)                                                          
      Infiltration Cellular, Histiocyte                             1 (1%)                                                          
      Inflammation, Chronic                                         1 (1%)                                                          
      Metaplasia, Lipocyte                             1 (1%)                                                                       
      Necrosis                                         1 (1%)       2 (2%)                                                          
      Pigmentation, Hemosiderin                       14 (13%)      8 (7%)                                                          
      Lymphoid Follicle, Hyperplasia                   1 (1%)                                                                       
   Thymus                                             (102)        (103)                                                            
      Ectopic Parathyroid Gland                                     1 (1%)                                                          
      Hemorrhage                                       1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (104)        (108)                                                            
      Hyperplasia                                     17 (16%)     18 (17%)                                                         
   Skin                                               (109)        (108)                                                            
      Acanthosis                                       4 (4%)       7 (6%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Cyst Epithelial Inclusion                        2 (2%)       2 (2%)                                                          
      Hemorrhage                                       1 (1%)       1 (1%)                                                          
      Hyperkeratosis                                   5 (5%)       7 (6%)                                                          
      Inflammation, Chronic                            1 (1%)       3 (3%)                                                          
      Inflammation, Chronic Active                                  1 (1%)                                                          
      Ulcer                                            3 (3%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (110)        (110)                                                            
      Cranium, Osteopetrosis                           3 (3%)       2 (2%)                                                          
      Femur, Osteopetrosis                             2 (2%)       3 (3%)                                                          
      Rib, Osteopetrosis                                            1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (110)        (109)                                                            
      Compression                                      3 (3%)       5 (5%)                                                          
      Hydrocephalus                                    4 (4%)       2 (2%)                                                          
      Necrosis                                                      3 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (110)        (110)                                                            
      Congestion                                                    1 (1%)                                                          
      Edema                                            2 (2%)       1 (1%)                                                          
      Hemorrhage                                       1 (1%)       1 (1%)                                                          
      Infiltration Cellular, Histiocyte               13 (12%)     24 (22%)                                                         
      Inflammation, Subacute                           1 (1%)       2 (2%)                                                          
      Inflammation, Suppurative                                     1 (1%)                                                          
      Alveolar Epithelium, Hyperplasia                11 (10%)      6 (5%)                                                          
   Nose                                               (110)        (110)                                                            
      Exudate                                         21 (19%)     14 (13%)                                                         
      Foreign Body                                     8 (7%)       3 (3%)                                                          
      Fungus                                          15 (14%)      9 (8%)                                                          
      Mucosa, Hyperplasia                             14 (13%)      8 (7%)                                                          
      Mucosa, Metaplasia, Squamous                    15 (14%)      6 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05094-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 14:12:18  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                                                              
      Hemorrhage                                       1 (100%)                                                                     
      Inflammation, Chronic                            1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (110)        (109)                                                            
      Calculus Micro Observation Only                  2 (2%)       1 (1%)                                                          
      Congestion                                                    1 (1%)                                                          
      Cyst                                             2 (2%)       3 (3%)                                                          
      Hydronephrosis                                                1 (1%)                                                          
      Mineralization                                  11 (10%)     10 (9%)                                                          
      Nephropathy                                    100 (91%)    104 (95%)                                                         
      Thrombosis                                       1 (1%)       2 (2%)                                                          
      Renal Tubule, Atrophy                            1 (1%)       3 (3%)                                                          
      Renal Tubule, Dilatation                         4 (4%)       8 (7%)                                                          
      Renal Tubule, Hyperplasia                                     1 (1%)                                                          
      Renal Tubule, Necrosis                           5 (5%)       5 (5%)                                                          
      Renal Tubule, Pigmentation                     105 (95%)    104 (95%)                                                         
      Transitional Epithelium, Hyperplasia             3 (3%)       3 (3%)                                                          
   Urinary Bladder                                    (110)        (110)                                                            
      Hemorrhage                                                    3 (3%)                                                          
      Transitional Epithelium, Hyperplasia             1 (1%)       3 (3%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
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