TDMS Study 05094-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst BUTYL BENZYL PHTHALATE DATE: 04/03/96
EXPERIMENT: 05094 TEST: 03 TIME: 18:24:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85222 ROUTE: DOSED FEED NTP C#: 54375C
PATHOLOGIST: DR J. E. HEATH CAS: 85-68-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst BUTYL BENZYL PHTHALATE DATE: 04/03/96
EXPERIMENT: 05094 TEST: 03 TIME: 18:24:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85222 ROUTE: DOSED FEED NTP C#: 54375C
PATHOLOGIST: DR J. E. HEATH CAS: 85-68-7
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 897 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATDCONTROL |
| ---------------------------- |
| |
| TOTAL 110 UNCENSORED DEATHS 55 CENSORED DEATHS 45 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 432 467 507 516 549 569 583 597 600 617 |
| 617 619 645 645 655 656 661 667 670 681 |
| 682 682 696 698 701 703 709 710 719 719 |
| 719 723 723 730 740 744 746 754 755 757 |
| 761 768 777 785 785 796 796 798 798 813 |
| 823 824 839 868 893 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 729 729 729 729 729 729 729 729 729 729 |
| 729 729 729 729 729 729 729 729 729 729 |
| 729 729 729 729 729 729 729 729 729 729 |
| 729 729 729 729 729 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.2% |
| --------------------- |
| |
| TOTAL 110 UNCENSORED DEATHS 56 CENSORED DEATHS 41 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 54 90 350 498 499 508 521 530 536 540 |
| 579 589 589 605 610 619 619 628 633 634 |
| 635 641 663 667 669 674 674 675 677 684 |
| 687 698 709 715 716 719 723 723 723 737 |
| 737 737 755 775 785 796 798 806 807 807 |
| 827 844 844 844 869 876 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 729 729 729 729 729 729 729 729 729 729 |
| 730 730 730 730 730 730 730 730 730 730 |
| 730 730 730 730 730 730 730 730 730 730 |
| 730 |
| |
==================================================================================
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 897 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 897 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATDCON|ROL100.0 100.0 100.0 100.0 100.0 98.1 96.1 91.1 83.1 21.0 |
|U | |
| | |
|1.2% | 98.2 98.2 98.2 97.3 97.3 97.3 90.3 86.2 77.2 26.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATDCONTROL 1.2% |
| U |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 21.0% 26.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 699.8 659.8 |
|NATURAL DEATHS (C) | (13.2) (21.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 704.9 689.1 |
|(STANDARD ERROR) | (11.3) (14.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 977 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATDCONTROL |
| ---------------------------- |
| |
| TOTAL 110 UNCENSORED DEATHS 55 CENSORED DEATHS 45 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 324 358 359 478 498 498 551 564 573 597 |
| 616 624 625 649 649 674 677 683 684 685 |
| 687 687 687 687 694 696 702 705 705 712 |
| 722 740 744 747 750 754 754 793 796 816 |
| 823 829 844 844 858 872 900 914 915 922 |
| 928 949 967 970 971 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 730 730 730 730 730 730 730 730 730 730 |
| 730 730 730 730 730 730 730 730 730 730 |
| 730 731 731 731 731 731 731 731 731 731 |
| 731 731 731 731 731 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.4% |
| --------------------- |
| |
| TOTAL 110 UNCENSORED DEATHS 50 CENSORED DEATHS 49 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 428 498 530 592 600 634 634 652 652 667 |
| 677 683 684 684 696 705 715 715 716 719 |
| 719 731 737 740 740 775 779 796 806 813 |
| 824 832 838 838 845 845 858 871 872 885 |
| 886 907 907 927 928 936 936 970 971 971 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 730 730 730 730 730 731 731 731 731 731 |
| 731 731 731 731 731 731 731 731 731 731 |
| 731 731 731 731 731 731 731 731 731 731 |
| 731 731 731 731 731 731 731 731 731 |
| |
==================================================================================
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 977 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 977 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATDCON|ROL100.0 100.0 100.0 97.3 97.3 96.3 94.3 90.3 85.2 20.4 |
|U | |
| | |
|2.4% | 100.0 100.0 100.0 100.0 100.0 99.1 97.1 95.1 91.1 22.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATDCONTROL 2.4% |
| U |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 20.4% 22.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.303N P=0.303N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 717.3 767.3 |
|NATURAL DEATHS (C) | (20.7) (18.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 721.4 747.1 |
|(STANDARD ERROR) | (14.8) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BUTYL BENZYL PHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATDCONTROL = 1
1.2% = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 2 1 1
| 2 2 1 211
| 221 1 11
| 2222 1 1
90 + 2 2 21 1
| 22 1 1
| 222 11
| 22 11
P 80 + 22 1 1
E | 2 22 11
R | 22 111
C | 1
E 70 + 222 11
N | 2 211
T | 2211
| 1
S 60 + 2 2
U | 11
R | 211
V | 2 2
I 50 + 11 22
V | 1
A | 1 122
L | 11
40 +
| 2 2 2
|
| 1 11
30 + 2 2
| 11 22 2
| 1 1
| 1 1
20 + 11
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 33 obs hidden.
BUTYL BENZYL PHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATDCONTROL = 1
2.4% = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 1 2 2
| 1 1 1 2 2
| 1 1 22 2
| 1 11 1 2 2
90 + 11 1 2222
| 1 1
| 1 12222
| 11
P 80 + 1 2 2
E | 22
R | 111
C | 2 2
E 70 + 111 1 22
N | 1 2 2
T | 222
| 11 22
S 60 + 2
U | 1 1 22
R | 22
V | 1 1
I 50 + 11 22
V | 1 12 2
A | 22
L | 11
40 + 1 12 2
| 1 11
| 2 2
| 1122
30 + 11
| 121 1
|
| 22
20 + 11
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 26 obs hidden.